T cell activation inhibitor, mitochondrial

Overview
NameT cell activation inhibitor, mitochondrial
Smed IDSMED30023276
Length (bp)908
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of T cell activation inhibitor, mitochondrial (SMED30023276) t-SNE clustered cells

Violin plots show distribution of expression levels for T cell activation inhibitor, mitochondrial (SMED30023276) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of T cell activation inhibitor, mitochondrial (SMED30023276) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for T cell activation inhibitor, mitochondrial (SMED30023276) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023276

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30023276SMESG000063165.1 dd_Smed_v4_2607_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30023276SMESG000063165.1 dd_Smed_v4_2607_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Match: TCAIM (T cell activation inhibitor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:25241])

HSP 1 Score: 87.4261 bits (215), Expect = 1.088e-18
Identity = 74/296 (25.00%), Postives = 131/296 (44.26%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSC-------QAF-ANIDDIPRK--KYVEDMTYKFD---------FDP-KCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDIS 830
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +          + S    +   L  R++ + +  IL SC       Q+   N+   P K  K + D   K+D          DP +   +       +  WL  +  + +K  + S+ LR +++ +   ++ +  +S + W+ ++    + + + SL R+ +             II+T  ++SG++  G ++L    V   W+K F  +   +     + +LE  IS
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFT--DRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQIS 318
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Match: TCAIM (T cell activation inhibitor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:25241])

HSP 1 Score: 87.4261 bits (215), Expect = 1.088e-18
Identity = 74/296 (25.00%), Postives = 131/296 (44.26%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSC-------QAF-ANIDDIPRK--KYVEDMTYKFD---------FDP-KCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDIS 830
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +          + S    +   L  R++ + +  IL SC       Q+   N+   P K  K + D   K+D          DP +   +       +  WL  +  + +K  + S+ LR +++ +   ++ +  +S + W+ ++    + + + SL R+ +             II+T  ++SG++  G ++L    V   W+K F  +   +     + +LE  IS
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFT--DRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQIS 318
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Match: TCAIM (T cell activation inhibitor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:25241])

HSP 1 Score: 59.6918 bits (143), Expect = 1.056e-10
Identity = 32/72 (44.44%), Postives = 42/72 (58.33%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENKS 257
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +  S
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSS 96
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Match: TCAIM (T cell activation inhibitor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:25241])

HSP 1 Score: 59.3066 bits (142), Expect = 1.288e-10
Identity = 32/72 (44.44%), Postives = 42/72 (58.33%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENKS 257
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +  S
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSS 96
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Match: TCAIM (T cell activation inhibitor, mitochondrial [Source:HGNC Symbol;Acc:HGNC:25241])

HSP 1 Score: 59.3066 bits (142), Expect = 1.288e-10
Identity = 32/72 (44.44%), Postives = 42/72 (58.33%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENKS 257
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +  S
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSS 96
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Fly
Match: CG13295 (gene:FBgn0035674 transcript:FBtr0077065)

HSP 1 Score: 62.003 bits (149), Expect = 1.890e-10
Identity = 64/291 (21.99%), Postives = 120/291 (41.24%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYDKVIS---LQFYVRQIENKSK---LSVINICL---KERNIHNAISQILTSC----------------QAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXXXXXI-IYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R+   Q+  + L+PF F VHPDFF Q P+ +  N+ SLKLL  +L +L  +  +      L+FYVR   +  K     +I I       R+    I  +L SC                   + +D  P   Y  DM +  +F+ +  +        +  WL+ +     +  +++  L+ +I+++  ++  + ++    +   +N       + +L R+     L ++     I      +GI+  G ++L    V  TW     NI  +  +L  + + E  +S  L N
Sbjct:   23 RRSLNQDLTTALRPFYFAVHPDFFAQHPEQRNTNENSLKLLSEHLEALYERRQRSGDTQVLKFYVRTSSDADKRDSFKLIQIRTDWQSTRDPKTFIQGLLESCNLSTEYVKNIKAQPEPPKTSGLDFKPSHDYHYDMEFA-EFETQLKNERASKRPVLTTWLEENAGTAKQRSKETADLQAEIDKLKKMLVEKLELQDARYECGWNIEHYRGCLKTLERLSNTHLLEMASLKGRIVVFAPFTGISLEGHVMLFTGDVLSTWIDFIKNIPHHDAYLKVVPVYERTLSQVLLN 312
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Zebrafish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-160113-67])

HSP 1 Score: 80.8777 bits (198), Expect = 1.335e-16
Identity = 64/277 (23.10%), Postives = 127/277 (45.85%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSCQ-AFANIDDIPRKKYVEDMT-----------------YKFDF--DPKC---YSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  + I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL ++     ++ K  +  FYVR  + K         S    ++  L+ +++ + +  +L SC  +  ++ D+ + +  +  T                 Y F    DP+     +R VE  +++  WL+ +     K +  S+  R ++  +   +  +  + ++ W+  +    + + + SL R+      +   L  + II+T  ++SG+N  G ++L    V   W+K F
Sbjct:   25 RNLSGADAINALRPFYFAVHPDFFGQHPREREVNENSLKRLNGYLENIQKPGERFPKPTNFTFYVRDTKEKSDPNGSLLVSGFRSVSFTLQSKDVLSTVLDVLRSCSLSVEHMQDVLKHETTKSSTQQPGTAFYRPIKWDKTYYTFTGFRDPEQELEQARRVEPTLSL--WLRKNEPEATKKQNASLPHREELKRLKRELIQKLGLLNIRWQRKWGVAHKCSQLQSLSRLSTQSPEALLNLRGHIIIFT--DQSGMNASGHVMLGTTDVHHQWTKLF 297
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Zebrafish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-160113-67])

HSP 1 Score: 80.8777 bits (198), Expect = 1.335e-16
Identity = 64/277 (23.10%), Postives = 127/277 (45.85%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSCQ-AFANIDDIPRKKYVEDMT-----------------YKFDF--DPKC---YSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  + I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL ++     ++ K  +  FYVR  + K         S    ++  L+ +++ + +  +L SC  +  ++ D+ + +  +  T                 Y F    DP+     +R VE  +++  WL+ +     K +  S+  R ++  +   +  +  + ++ W+  +    + + + SL R+      +   L  + II+T  ++SG+N  G ++L    V   W+K F
Sbjct:   25 RNLSGADAINALRPFYFAVHPDFFGQHPREREVNENSLKRLNGYLENIQKPGERFPKPTNFTFYVRDTKEKSDPNGSLLVSGFRSVSFTLQSKDVLSTVLDVLRSCSLSVEHMQDVLKHETTKSSTQQPGTAFYRPIKWDKTYYTFTGFRDPEQELEQARRVEPTLSL--WLRKNEPEATKKQNASLPHREELKRLKRELIQKLGLLNIRWQRKWGVAHKCSQLQSLSRLSTQSPEALLNLRGHIIIFT--DQSGMNASGHVMLGTTDVHHQWTKLF 297
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Zebrafish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-160113-67])

HSP 1 Score: 80.8777 bits (198), Expect = 1.349e-16
Identity = 64/277 (23.10%), Postives = 127/277 (45.85%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSCQ-AFANIDDIPRKKYVEDMT-----------------YKFDF--DPKC---YSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  + I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL ++     ++ K  +  FYVR  + K         S    ++  L+ +++ + +  +L SC  +  ++ D+ + +  +  T                 Y F    DP+     +R VE  +++  WL+ +     K +  S+  R ++  +   +  +  + ++ W+  +    + + + SL R+      +   L  + II+T  ++SG+N  G ++L    V   W+K F
Sbjct:   21 RNLSGADAINALRPFYFAVHPDFFGQHPREREVNENSLKRLNGYLENIQKPGERFPKPTNFTFYVRDTKEKSDPNGSLLVSGFRSVSFTLQSKDVLSTVLDVLRSCSLSVEHMQDVLKHETTKSSTQQPGTAFYRPIKWDKTYYTFTGFRDPEQELEQARRVEPTLSL--WLRKNEPEATKKQNASLPHREELKRLKRELIQKLGLLNIRWQRKWGVAHKCSQLQSLSRLSTQSPEALLNLRGHIIIFT--DQSGMNASGHVMLGTTDVHHQWTKLF 293
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Zebrafish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:ZFIN;Acc:ZDB-GENE-160113-67])

HSP 1 Score: 80.4925 bits (197), Expect = 1.674e-16
Identity = 64/277 (23.10%), Postives = 127/277 (45.85%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSCQ-AFANIDDIPRKKYVEDMT-----------------YKFDF--DPKC---YSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  + I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL ++     ++ K  +  FYVR  + K         S    ++  L+ +++ + +  +L SC  +  ++ D+ + +  +  T                 Y F    DP+     +R VE  +++  WL+ +     K +  S+  R ++  +   +  +  + ++ W+  +    + + + SL R+      +   L  + II+T  ++SG+N  G ++L    V   W+K F
Sbjct:   36 RNLSGADAINALRPFYFAVHPDFFGQHPREREVNENSLKRLNGYLENIQKPGERFPKPTNFTFYVRDTKEKSDPNGSLLVSGFRSVSFTLQSKDVLSTVLDVLRSCSLSVEHMQDVLKHETTKSSTQQPGTAFYRPIKWDKTYYTFTGFRDPEQELEQARRVEPTLSL--WLRKNEPEATKKQNASLPHREELKRLKRELIQKLGLLNIRWQRKWGVAHKCSQLQSLSRLSTQSPEALLNLRGHIIIFT--DQSGMNASGHVMLGTTDVHHQWTKLF 308
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Xenopus
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:549618])

HSP 1 Score: 85.1149 bits (209), Expect = 7.353e-18
Identity = 64/273 (23.44%), Postives = 117/273 (42.86%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIEN--------KSKLSVINICLKERNIHNAISQILTSCQ--------AFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  +  + L+PF F VHPDFF Q P  +E+N+ SLK L  YL +L     K  K   L FYVR+            +    ++  L  R++ + +  IL SC         A   ++  P K           +D   YS T   +              I+ WL+ + +   K   KS  LR ++ ++ + +  +  +S + W+ ++    + + + SL R+++             +++T  E++G++  G ++L    V   W+K F
Sbjct:   25 RPLSGADAATALRPFYFAVHPDFFGQHPVEREVNENSLKRLNGYLENLQKPGQKSHKPAQLTFYVRETNTINDSDTIRTTGFRTVHFTLDTRDLLSTVLDILNSCSLSTAHVNTAEVGMESKPHKGTKAAFDRPIKWDKTYYSFTGFKDPEEELEQAQKVETTIIPWLENNQSLANKKLTKSFPLREELEQLKNELADQLQLSDIRWQRSWGVAHRCSQLHSLSRLIQQNPETLKMAKGRTLLFT--EETGMSASGHVMLGTMDVHHQWAKLF 295
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Xenopus
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:549618])

HSP 1 Score: 84.7297 bits (208), Expect = 7.560e-18
Identity = 64/273 (23.44%), Postives = 117/273 (42.86%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIEN--------KSKLSVINICLKERNIHNAISQILTSCQ--------AFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  +  + L+PF F VHPDFF Q P  +E+N+ SLK L  YL +L     K  K   L FYVR+            +    ++  L  R++ + +  IL SC         A   ++  P K           +D   YS T   +              I+ WL+ + +   K   KS  LR ++ ++ + +  +  +S + W+ ++    + + + SL R+++             +++T  E++G++  G ++L    V   W+K F
Sbjct:   21 RPLSGADAATALRPFYFAVHPDFFGQHPVEREVNENSLKRLNGYLENLQKPGQKSHKPAQLTFYVRETNTINDSDTIRTTGFRTVHFTLDTRDLLSTVLDILNSCSLSTAHVNTAEVGMESKPHKGTKAAFDRPIKWDKTYYSFTGFKDPEEELEQAQKVETTIIPWLENNQSLANKKLTKSFPLREELEQLKNELADQLQLSDIRWQRSWGVAHRCSQLHSLSRLIQQNPETLKMAKGRTLLFT--EETGMSASGHVMLGTMDVHHQWAKLF 291
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Xenopus
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:549618])

HSP 1 Score: 84.7297 bits (208), Expect = 9.988e-18
Identity = 64/273 (23.44%), Postives = 117/273 (42.86%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSL---DNKYDKVISLQFYVRQIEN--------KSKLSVINICLKERNIHNAISQILTSCQ--------AFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEF 767
            R ++  +  + L+PF F VHPDFF Q P  +E+N+ SLK L  YL +L     K  K   L FYVR+            +    ++  L  R++ + +  IL SC         A   ++  P K           +D   YS T   +              I+ WL+ + +   K   KS  LR ++ ++ + +  +  +S + W+ ++    + + + SL R+++             +++T  E++G++  G ++L    V   W+K F
Sbjct:   50 RPLSGADAATALRPFYFAVHPDFFGQHPVEREVNENSLKRLNGYLENLQKPGQKSHKPAQLTFYVRETNTINDSDTIRTTGFRTVHFTLDTRDLLSTVLDILNSCSLSTAHVNTAEVGMESKPHKGTKAAFDRPIKWDKTYYSFTGFKDPEEELEQAQKVETTIIPWLENNQSLANKKLTKSFPLREELEQLKNELADQLQLSDIRWQRSWGVAHRCSQLHSLSRLIQQNPETLKMAKGRTLLFT--EETGMSASGHVMLGTMDVHHQWAKLF 320
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Mouse
Match: Tcaim (T cell activation inhibitor, mitochondrial [Source:MGI Symbol;Acc:MGI:1196217])

HSP 1 Score: 84.7297 bits (208), Expect = 7.620e-18
Identity = 68/302 (22.52%), Postives = 129/302 (42.72%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQ--IENKSK---------LSVINICLKERNIHNAISQILTSC-------------------QAFANIDDIPRKKYVEDMTYKFDFDP-KCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXX---XXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL +L     K  K   L FY+R+   +N S+            +   L   ++ + +  IL SC                   +    + D P K +    ++    DP +  +        +  WL ++    +K    S+ LR +++ + + ++    +S + W+  +    + + + SL R+ +     L       +++T  ++SG++  G ++L    V   W++ F ++   +     +  LE  ISN L  
Sbjct:   35 RALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPISTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLTHVSRVETTLTSWLGSNGKGAVKKLRNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNPGPLQNVKGCTVVFT--DRSGMSALGHVMLGTMDVHHHWTRLFESLPSYFDLQRRMSALEAQISNLLGG 334
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Mouse
Match: Tcaim (T cell activation inhibitor, mitochondrial [Source:MGI Symbol;Acc:MGI:1196217])

HSP 1 Score: 60.4622 bits (145), Expect = 5.087e-11
Identity = 30/67 (44.78%), Postives = 41/67 (61.19%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQ 242
            R ++  E I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL +L     K  K   L FY+R+
Sbjct:   35 RALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIRE 101
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. UniProt/SwissProt
Match: sp|Q8N3R3|TCAIM_HUMAN (T-cell activation inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=TCAIM PE=2 SV=2)

HSP 1 Score: 87.4261 bits (215), Expect = 5.224e-18
Identity = 74/296 (25.00%), Postives = 131/296 (44.26%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSC-------QAF-ANIDDIPRK--KYVEDMTYKFD---------FDP-KCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDIS 830
            R ++  E ++ L+PF F VHPDFF Q P  +EIN+ SLK L  YL +L     K  K   L FYVR+ +          + S    +   L  R++ + +  IL SC       Q+   N+   P K  K + D   K+D          DP +   +       +  WL  +  + +K  + S+ LR +++ +   ++ +  +S + W+ ++    + + + SL R+ +             II+T  ++SG++  G ++L    V   W+K F  +   +     + +LE  IS
Sbjct:   25 RALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLSRLAQQNLETLKKAKGCTIIFT--DRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQIS 318
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. UniProt/SwissProt
Match: sp|Q66JZ4|TCAIM_MOUSE (T-cell activation inhibitor, mitochondrial OS=Mus musculus OX=10090 GN=TCAIM PE=1 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 5.172e-17
Identity = 68/302 (22.52%), Postives = 129/302 (42.72%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQ--IENKSK---------LSVINICLKERNIHNAISQILTSC-------------------QAFANIDDIPRKKYVEDMTYKFDFDP-KCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXX---XXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL +L     K  K   L FY+R+   +N S+            +   L   ++ + +  IL SC                   +    + D P K +    ++    DP +  +        +  WL ++    +K    S+ LR +++ + + ++    +S + W+  +    + + + SL R+ +     L       +++T  ++SG++  G ++L    V   W++ F ++   +     +  LE  ISN L  
Sbjct:   25 RALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPISTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLTHVSRVETTLTSWLGSNGKGAVKKLRNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNPGPLQNVKGCTVVFT--DRSGMSALGHVMLGTMDVHHHWTRLFESLPSYFDLQRRMSALEAQISNLLGG 324
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. UniProt/SwissProt
Match: sp|P0DKR2|TCAIM_RAT (T-cell activation inhibitor, mitochondrial OS=Rattus norvegicus OX=10116 GN=Tcaim PE=2 SV=1)

HSP 1 Score: 82.4185 bits (202), Expect = 3.220e-16
Identity = 72/305 (23.61%), Postives = 134/305 (43.93%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQ--IENKSK---------LSVINICLKERNIHNAISQILTSC-------QAF-ANIDDIPRKKY--VEDMTYKF-------------DFDPKCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E I+ L+PF F VHPDFF Q P+ +E+N+ SLK L  YL +L     K  K   L FY+R+   +N S+            +   L   ++ + +  IL SC       Q+   N+   P K+   + D   K+             D D +  SR       +  WL ++    +K  + S+ LR +++ + + ++    +S + W+  +    + + + SL R+ +       +     I++T  ++SG++  G ++L    V   W++ F ++   +     +  LE  IS+ L  
Sbjct:   35 RALSGAEAINALRPFYFAVHPDFFGQHPREREVNENSLKRLSVYLENLQKPGFKSLKPTQLTFYIREKTAQNSSEGQEPVSTTGFRAVRFTLHSSDLLSTVLYILNSCSLPVEHVQSLNTNVHSQPLKEATGMPDRPIKWHRSYYSFTGFKDPDEDLEHVSRV---ETTLTSWLGSNGKGAVKKLKNSLPLRKELDRLKNELSELLQLSDIRWQRGWGVAHRCSQLHSLSRLAQQNLEPLQNAKGCTIVFT--DRSGMSALGHVMLGTMDVHHHWTRLFESLPNYFDLQRRMSALEDQISHLLGG 334
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Match: A0A099YVS1 (Uncharacterized protein (Fragment) OS=Tinamus guttatus OX=94827 GN=N309_08138 PE=4 SV=1)

HSP 1 Score: 102.834 bits (255), Expect = 8.681e-21
Identity = 75/301 (24.92%), Postives = 140/301 (46.51%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSCQAFA------NIDDIPRKKYVEDMTYKFDFDPKCYS--------------RTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  + ++ L+PF F VHPDFF Q PK +E+N+ SLK L  YL +L     +  K   L FYVR+ E          + S    ++  L+ R++ + +  IL SC          +++  PRK+    +     +D   YS              R VE    ++ WL  +  N +K  +KS+ LR ++  +   ++ +  +S + W+ ++    + + + SL R+++    +   +  + +I+T  ++SG++  G ++L    V   W+K F  +   Y+    +  LE  IS+ L  
Sbjct:   18 RSLSGADAVNALRPFYFAVHPDFFGQHPKEREVNENSLKRLNGYLENLQKPGFRSFKPTRLTFYVRESEPNSCNAQESFSASGFRAVSFTLRTRDLLSTVLAILNSCSLSTEHVQSLHVNSQPRKEAKAVLNRPIKWDKTYYSFTGFKDPEEEIEQARRVET--TLISWLDDNEANAVKKLKKSLPLREELERLKFELSHQLQLSDIRWQRSWGVAHRCSQLHSLGRLVQQRPEALKNVKGHTLIFT--DRSGMSAAGHVMLGTMDVHHHWTKVFERLPNYYKLQKRVLFLEDQISHLLGG 314
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Match: K7F9N7 (T cell activation inhibitor, mitochondrial OS=Pelodiscus sinensis OX=13735 GN=TCAIM PE=4 SV=1)

HSP 1 Score: 102.834 bits (255), Expect = 9.142e-21
Identity = 79/301 (26.25%), Postives = 135/301 (44.85%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSC-------QAF-ANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E ++ L+PF F VHPDFF Q P+ +EIN+ SLK L  YL +L     KY K  SL FYVR+ E          + S    +   L  R++ + +  IL SC       Q+  AN++  P K+          +D   YS T   +              ++ WL  S  + IK    S+ LR +++ +   +  +  +S + W+ ++    + + + SL R+ +        +  + +++T  + SG++  G ++L    V   W K F  +   Y+    + LLE  IS+ L  
Sbjct:   25 RGLSGAEAVNALRPFYFAVHPDFFGQHPREREINENSLKRLNGYLENLQKPGFKYFKPTSLTFYVREREQNSSDVQESFSASGFRAVTFTLHTRDLLSTVLDILNSCSLSTEHVQSLNANVNSQPHKEVKGTFYRSIKWDKTYYSFTGFKDPEEELEQAQRVETTLISWLDDSGKSAIKKLRSSLPLREELSRLKDELAHQLQLSDIRWQRSWGIAHRCSQLHSLCRLAQQSPEPLRNVKGHTVVFT--DYSGMSATGHVMLGTMDVHHHWIKIFERLPSYYKLQKKVLLLEDHISHLLGG 323
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Match: A0A4D9EXM5 (Fibroblast growth factor 4B-like OS=Platysternon megacephalum OX=55544 GN=DR999_PMT04810 PE=4 SV=1)

HSP 1 Score: 102.449 bits (254), Expect = 1.178e-20
Identity = 78/297 (26.26%), Postives = 133/297 (44.78%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENKS----------KLSVINICLKERNIHNAISQILTSC----QAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXX---XXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E ++ L+PF F VHPDFF Q P+ +EIN+ SLK L  YL +L     K  K   L FYVR+ E  S              ++  L  R++ + +  IL SC    +   +++  P K+          +D   YS T   +            + ++ WL  S    IK   KS+ LR ++N +   +T +  +S + W+ ++    + + + SL R+ +     L     + +++T  + SG++  G ++L    V   W K F  +   Y+    + LLE  IS+ L  
Sbjct:   25 RPLSGAEAVNALRPFYFAVHPDFFGQHPREREINENSLKRLNGYLENLQKPGFKSFKPTQLTFYVREREQNSSDVQESFSAAGFRAVSFTLHTRDLLSTVLDILNSCSLSTEHVQSVNSQPHKEVKGTFYRPIKWDKTYYSFTGFKDPEEELEQAQRVEVTLISWLDNSEKGAIKKLRKSLPLREELNRLKDELTHQLQLSDIRWQRSWGIAHRCSQLHSLGRLAQQSPEVLRNVKGHTVVFT--DCSGMSATGHVMLGTMDVHHHWIKLFERLPSYYKLQKKMLLLEDRISHLLGG 319
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Match: A0A452GYH8 (T cell activation inhibitor, mitochondrial OS=Gopherus agassizii OX=38772 GN=TCAIM PE=4 SV=1)

HSP 1 Score: 102.449 bits (254), Expect = 1.236e-20
Identity = 79/297 (26.60%), Postives = 134/297 (45.12%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENKS----------KLSVINICLKERNIHNAISQILTSC----QAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXX---XXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  E ++ L+PF F VHPDFF Q P+ +EIN+ SLK L  YL +L     K  K   L FYVR+ E  S              ++  L  R++ + +  IL SC    +   +++  P K+          +D   YS T   +            I ++ WL  S  + IK   KS+ LR ++N +   +T +  +S + W+ ++    + + + SL R+ +     L     + +++T  + SG++  G ++L    V   W K F  +   Y+    + LLE  IS+ L  
Sbjct:   25 RPLSGAEAVNALRPFYFAVHPDFFGQHPREREINENSLKRLNGYLENLQKPGFKSFKPTQLTFYVREREQNSSDVQESFSAAGFRAVSFTLHTRDLLSTVLDILNSCSLSTEHVQSVNSQPHKEVKGTFYRPIKWDKTYYSFTGFKDPEEELEQAQRVEITLISWLDNSEKSAIKKLRKSLPLREELNRLKDELTHQLQLSDIRWQRSWGIAHRCSQLHSLGRLAQQSPEVLRNVKGHTVVFT--DCSGMSATGHVMLGTMDVHHHWIKIFERLPSYYKLQKKMLLLEDRISHLLGG 319
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Match: A0A093LCW4 (Uncharacterized protein (Fragment) OS=Eurypyga helias OX=54383 GN=N326_02544 PE=4 SV=1)

HSP 1 Score: 100.908 bits (250), Expect = 1.296e-20
Identity = 74/299 (24.75%), Postives = 136/299 (45.48%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIE----------NKSKLSVINICLKERNIHNAISQILTSCQAFA------NIDDIPRKKYVEDMTYKFDFDPKCYSRTVENN------------INIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXX---XXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQN 845
            R ++  + I+ L+PF F VHPDFF Q PK +E+N+ SLK L  YL +L     +  K   L FYVR+ E          + S    ++  L  R++ + +  IL SC          N++  P K+    +     +D   YS T   +              ++ WL  +  + +K  +KS+ LR ++  + S ++ +  +S + W+ ++    + + + SL R+++        +    +++T  ++SG++  G ++L    V   W+K F  +   Y+    + LLE  IS  L  
Sbjct:   21 RTLSGADAINALRPFYFAVHPDFFGQHPKEREVNENSLKRLNGYLENLQKPGFRSFKPTQLTFYVREREPNSSNVQESFSASGFRAVSFTLHTRDLLSTVLDILNSCSLSTEHVQSLNVNSQPHKEAKSTVNRPIKWDKTYYSFTGFKDPEEELEQAQRVETTLISWLDDNEASAVKKLKKSLPLRKELERLKSELSHQLQLSDIRWQRSWGIAHRCSQLHSLGRLVQQRPEVLKNVKGRTVVFT--DRSGMSAAGHIMLGTMDVHHHWTKVFERLPNYYKLQKRLLLLEDRISQLLGG 317
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Cavefish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:103033408])

HSP 1 Score: 77.7962 bits (190), Expect = 9.746e-16
Identity = 75/301 (24.92%), Postives = 131/301 (43.52%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSC-----------------QAFANIDDIPRKKYVE-DMTYKFDF----DPKC-YSRTVENNINIVEWLKTSINNEIKAREK---SVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVL---KXXXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDIS 830
            R ++  + ++ L+PF F VHPDFF Q PK +E+N+ SLK L  YL +L     +  K   L FYVR  + K         S    +   L+ +++ + + ++L SC                 Q       IP  + ++ D TY + F    DP+    +  +    +  WL+   NNE +A +K   SV  R ++  +   +  +  +  + W+  +    +   + SL R+        L+L  + +I+T  ++SG+N  G ++L    V   W+K F  +           LL+  IS
Sbjct:   24 RALSGADAVNALRPFYFAVHPDFFGQHPKEREVNENSLKRLNGYLENLQKPGMRSLKPTKLTFYVRDTKEKTDSESNLLPSGFRSVTFTLQSKDVLSTVMEVLKSCSLSVEHMQELLKAKAESQNSTQQGGIPFYRPIKWDKTY-YSFTGFRDPEQEMEQAKKMEATLSSWLQ---NNEPEATKKQNASVPRRAELKRLKRELIEKLGLVDIRWQRKWGVAHRCCQLQSLSRLALQSPEALLNLRGHTVIFT--DQSGMNASGHVMLGTMDVHHQWTKLFQRLPSYCSLFQQTVLLKERIS 318
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Cavefish
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:103033408])

HSP 1 Score: 77.7962 bits (190), Expect = 9.746e-16
Identity = 75/301 (24.92%), Postives = 131/301 (43.52%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDN---KYDKVISLQFYVRQIENK---------SKLSVINICLKERNIHNAISQILTSC-----------------QAFANIDDIPRKKYVE-DMTYKFDF----DPKC-YSRTVENNINIVEWLKTSINNEIKAREK---SVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVL---KXXXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDIS 830
            R ++  + ++ L+PF F VHPDFF Q PK +E+N+ SLK L  YL +L     +  K   L FYVR  + K         S    +   L+ +++ + + ++L SC                 Q       IP  + ++ D TY + F    DP+    +  +    +  WL+   NNE +A +K   SV  R ++  +   +  +  +  + W+  +    +   + SL R+        L+L  + +I+T  ++SG+N  G ++L    V   W+K F  +           LL+  IS
Sbjct:   24 RALSGADAVNALRPFYFAVHPDFFGQHPKEREVNENSLKRLNGYLENLQKPGMRSLKPTKLTFYVRDTKEKTDSESNLLPSGFRSVTFTLQSKDVLSTVMEVLKSCSLSVEHMQELLKAKAESQNSTQQGGIPFYRPIKWDKTY-YSFTGFRDPEQEMEQAKKMEATLSSWLQ---NNEPEATKKQNASVPRRAELKRLKRELIEKLGLVDIRWQRKWGVAHRCCQLQSLSRLALQSPEALLNLRGHTVIFT--DQSGMNASGHVMLGTMDVHHQWTKLFQRLPSYCSLFQQTVLLKERIS 318
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Nematostella
Match: EDO46002 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRF5])

HSP 1 Score: 70.0922 bits (170), Expect = 1.486e-13
Identity = 40/109 (36.70%), Postives = 60/109 (55.05%), Query Frame = 3 
Query:   51 RQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYD-KVISLQFYVRQIEN--KSKLSVINICLKERNIHNAISQILTSC---QAFANIDDI 359
            R ++ Q+  + LKPF F VHPD F Q P  +  N+ SLK L +Y+ +L+NKY      L FY++  E   + K   + I L  R++   +SQIL SC   + F  +D +
Sbjct:   93 RLLSNQQTKAALKPFYFAVHPDLFGQHPTQRATNEDSLKRLNSYIDNLENKYPVSPTHLTFYIKDDEQVEQEKFKTVRISLYSRDLGYTVSQILKSCGMIKDFVAVDPV 201
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Medaka
Match: tcaim (T cell activation inhibitor, mitochondrial [Source:NCBI gene;Acc:101168317])

HSP 1 Score: 89.7373 bits (221), Expect = 9.339e-20
Identity = 70/282 (24.82%), Postives = 126/282 (44.68%), Query Frame = 3 
Query:   45 NYRQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYDKVIS---LQFYVRQIEN---------KSKLSVINICLKERNIHNAISQILTSC---------QAFANIDDIPRKKYVE-------DMTYKFDF----DPK---CYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKX---XXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNI 776
             +R ++  E ++ L+PF   VHPDFF Q PK +E+N+ SLK L  YL SL     + I    L FY+R  ++          S    ++  L+  ++ + + ++L SC                  P K  V        D +Y + F    DP+     +R VE  + +  WLK +    +K    S+  R +++ +   +   FD+  + W+ ++    +Y+ + SL R+        + L  + I++   ++SG+N  G +LL    V   W+K F+ +
Sbjct:   20 QFRALSGAEAVNALRPFYLAVHPDFFGQHPKEREVNENSLKRLNGYLESLQKSGSRHIEPTRLTFYMRDTKDSSNTQAEPLSSGFRTVSFTLRTNDVQSTVMEVLGSCSLSVEHMQEHRGTEPSKGPLKGGVPFYRPIKWDKSY-YAFTGFRDPEEELEQARRVEPILKV--WLKNNKPKAMKKHNASLPRREELSRLKRELCDRFDLLDIRWQRSWGVAHRYSQLQSLTRLAHQNPDALIHLQGHTIVFA--DQSGMNSSGHVLLGTMDVHHQWTKLFVQL 296
[Close]
BLAST of T cell activation inhibitor, mitochondrial vs. Planmine SMEST
Match: SMESG000063165.1 (SMESG000063165.1)

HSP 1 Score: 516.924 bits (1330), Expect = 0.000e+0
Identity = 268/275 (97.45%), Postives = 269/275 (97.82%), Query Frame = 3 
Query:   57 MTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYDKVISLQFYVRQIENKSKLSVINICLKERNIHNAISQILTSCQAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKXXXXXXXXXXIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQNSKARFLLHF*KS 881
            MTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYDKVISLQFYVRQIENKSKLSVINICLKERNIHNAISQILTSCQAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKNLNLSLSLNNIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQNSK   L  F K+
Sbjct:    1 MTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSLKLLYNYLHSLDNKYDKVISLQFYVRQIENKSKLSVINICLKERNIHNAISQILTSCQAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENNINIVEWLKTSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNAIVSLYRVLKNLNLSLSLNNIIYTSDEKSGINCYGDMLLSCQQVEDTWSKEFLNIHRNYQFLSDIKLLETDISNQLQNSKVHLLNDFHKT 275
The following BLAST results are available for this feature:
BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TCAIM1.088e-1825.00T cell activation inhibitor, mitochondrial [Source... [more]
TCAIM1.088e-1825.00T cell activation inhibitor, mitochondrial [Source... [more]
TCAIM1.056e-1044.44T cell activation inhibitor, mitochondrial [Source... [more]
TCAIM1.288e-1044.44T cell activation inhibitor, mitochondrial [Source... [more]
TCAIM1.288e-1044.44T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG132951.890e-1021.99gene:FBgn0035674 transcript:FBtr0077065[more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
tcaim1.335e-1623.10T cell activation inhibitor, mitochondrial [Source... [more]
tcaim1.335e-1623.10T cell activation inhibitor, mitochondrial [Source... [more]
tcaim1.349e-1623.10T cell activation inhibitor, mitochondrial [Source... [more]
tcaim1.674e-1623.10T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tcaim7.353e-1823.44T cell activation inhibitor, mitochondrial [Source... [more]
tcaim7.560e-1823.44T cell activation inhibitor, mitochondrial [Source... [more]
tcaim9.988e-1823.44T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Tcaim7.620e-1822.52T cell activation inhibitor, mitochondrial [Source... [more]
Tcaim5.087e-1144.78T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q8N3R3|TCAIM_HUMAN5.224e-1825.00T-cell activation inhibitor, mitochondrial OS=Homo... [more]
sp|Q66JZ4|TCAIM_MOUSE5.172e-1722.52T-cell activation inhibitor, mitochondrial OS=Mus ... [more]
sp|P0DKR2|TCAIM_RAT3.220e-1623.61T-cell activation inhibitor, mitochondrial OS=Ratt... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A099YVS18.681e-2124.92Uncharacterized protein (Fragment) OS=Tinamus gutt... [more]
K7F9N79.142e-2126.25T cell activation inhibitor, mitochondrial OS=Pelo... [more]
A0A4D9EXM51.178e-2026.26Fibroblast growth factor 4B-like OS=Platysternon m... [more]
A0A452GYH81.236e-2026.60T cell activation inhibitor, mitochondrial OS=Goph... [more]
A0A093LCW41.296e-2024.75Uncharacterized protein (Fragment) OS=Eurypyga hel... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tcaim9.746e-1624.92T cell activation inhibitor, mitochondrial [Source... [more]
tcaim9.746e-1624.92T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO460021.486e-1336.70Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tcaim9.339e-2024.82T cell activation inhibitor, mitochondrial [Source... [more]
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BLAST of T cell activation inhibitor, mitochondrial vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000063165.10.000e+097.45SMESG000063165.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023276 ID=SMED30023276|Name=T cell activation inhibitor, mitochondrial|organism=Schmidtea mediterranea sexual|type=transcript|length=908bp
ATTGGCTCTAAACAATGTTCAAATTCTTTAAATTATTATTTCTTAATTAT
CGACAAATGACTTATCAAGAAGGAATAAGTTATTTAAAGCCATTTATTTT
TAAAGTACATCCAGACTTTTTTGAACAACAGCCAAAAGCAAAAGAAATTA
ATCAAACATCATTAAAATTATTATATAATTACCTTCATTCATTAGATAAT
AAATATGATAAAGTAATTTCTCTTCAATTTTATGTCAGACAAATTGAGAA
CAAATCTAAGTTGTCGGTTATTAATATATGTCTTAAAGAACGAAATATAC
ACAATGCTATATCTCAAATATTAACATCGTGTCAAGCTTTTGCTAATATT
GATGACATTCCACGGAAAAAGTATGTAGAAGATATGACTTATAAATTCGA
TTTCGATCCAAAATGTTACAGTCGAACAGTTGAAAATAATATTAATATTG
TTGAATGGTTAAAAACGTCGATTAATAACGAGATAAAAGCCCGTGAAAAG
TCTGTGATTTTGAGAAATAAGATAAATGAAATAACATCTATTATTACGAC
TGAATTTGACGTTTCGAGTGTTATTTGGCGGTCTAATTATAATTACAATA
AACAATATAATGCAATTGTTTCTTTATACAGAGTGCTGAAGAATTTAAAT
TTGTCATTATCCTTGAATAATATTATTTATACATCAGATGAAAAAAGTGG
CATCAATTGCTATGGGGATATGCTTTTGTCATGCCAGCAAGTCGAAGATA
CTTGGAGTAAAGAGTTTCTAAATATTCATCGCAATTACCAATTTCTGAGT
GATATTAAATTATTAGAAACAGATATATCGAATCAGCTTCAGAATTCAAA
GGCTAGATTTTTACTTCATTTTTAAAAATCATTTTATTGATACAAAATTT
TACTGAAC
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protein sequence of SMED30023276-orf-1

>SMED30023276-orf-1 ID=SMED30023276-orf-1|Name=SMED30023276-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=287bp
MFKFFKLLFLNYRQMTYQEGISYLKPFIFKVHPDFFEQQPKAKEINQTSL
KLLYNYLHSLDNKYDKVISLQFYVRQIENKSKLSVINICLKERNIHNAIS
QILTSCQAFANIDDIPRKKYVEDMTYKFDFDPKCYSRTVENNINIVEWLK
TSINNEIKAREKSVILRNKINEITSIITTEFDVSSVIWRSNYNYNKQYNA
IVSLYRVLKNLNLSLSLNNIIYTSDEKSGINCYGDMLLSCQQVEDTWSKE
FLNIHRNYQFLSDIKLLETDISNQLQNSKARFLLHF*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
Vocabulary: INTERPRO
TermDefinition
IPR028031DUF4460
IPR027989DUF4461
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion