TLC domain-containing protein 2

Overview
NameTLC domain-containing protein 2
Smed IDSMED30023244
Length (bp)918
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TLC domain-containing protein 2 (SMED30023244) t-SNE clustered cells

Violin plots show distribution of expression levels for TLC domain-containing protein 2 (SMED30023244) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TLC domain-containing protein 2 (SMED30023244) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TLC domain-containing protein 2 (SMED30023244) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023244

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30023244SMESG000060101.1 SMESG000039123.1 dd_Smed_v4_4223_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Match: TLCD2 (TLC domain containing 2 [Source:HGNC Symbol;Acc:HGNC:33522])

HSP 1 Score: 117.472 bits (293), Expect = 1.409e-30
Identity = 64/200 (32.00%), Postives = 119/200 (59.50%), Query Frame = 3 
Query:  195 SKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            S ++  W++ N+  SL HS+LSGT ALL       + +D I+ +    L+LV+ S+GYF+ D  D++ N +  ++++L+ HH ++  C   +V S  ++G+++V+LL+E+NS  LH+R+LL  L        + + +  ++ +  +FR++ L WM+ WL      V     T+G +G+  + +M+IIL  RI+ +D ++S
Sbjct:   31 SAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLL-LLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQS 229
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Match: TLCD2 (TLC domain containing 2 [Source:HGNC Symbol;Acc:HGNC:33522])

HSP 1 Score: 117.472 bits (293), Expect = 1.409e-30
Identity = 64/200 (32.00%), Postives = 119/200 (59.50%), Query Frame = 3 
Query:  195 SKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            S ++  W++ N+  SL HS+LSGT ALL       + +D I+ +    L+LV+ S+GYF+ D  D++ N +  ++++L+ HH ++  C   +V S  ++G+++V+LL+E+NS  LH+R+LL  L        + + +  ++ +  +FR++ L WM+ WL      V     T+G +G+  + +M+IIL  RI+ +D ++S
Sbjct:   31 SAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLL-LLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQS 229
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Match: TLCD1 (TLC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25177])

HSP 1 Score: 114.775 bits (286), Expect = 9.262e-30
Identity = 66/216 (30.56%), Postives = 121/216 (56.02%), Query Frame = 3 
Query:  186 HKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS--VSRQRRIQIIT 827
            H  +   R W++ N+L S  HSI+SG +ALLC +Q  D+  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F   F+G  ++ LLVEV++IFL +R ++  +   +    YR+N  +N+  + +FR+   A++T + +   +  + G + +G + M  + +M II F R++ SDF       +Q + + +T
Sbjct:   34 HVRADPLRTWRWHNLLVSFAHSIVSGIWALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMK-ISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLM--LDVMIIIYFSRLLRSDFCPEHVPKKQHKDKFLT 246
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Match: TLCD1 (TLC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25177])

HSP 1 Score: 84.7297 bits (208), Expect = 4.494e-19
Identity = 51/183 (27.87%), Postives = 100/183 (54.64%), Query Frame = 3 
Query:  285 YQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS--VSRQRRIQIIT 827
            +Q  D+  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F   F+G  ++ LLVEV++IFL +R ++  +   +    YR+N  +N+  + +FR+   A++T + +   +  + G + +G + M  + +M II F R++ SDF       +Q + + +T
Sbjct:   20 WQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMK-ISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLM--LDVMIIIYFSRLLRSDFCPEHVPKKQHKDKFLT 199
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Match: TLCD1 (TLC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25177])

HSP 1 Score: 70.8626 bits (172), Expect = 2.153e-14
Identity = 38/125 (30.40%), Postives = 72/125 (57.60%), Query Frame = 3 
Query:  342 ILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIG 716
            +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F   F+G  ++ LLVEV++IFL +R ++  +   +    YR+N  +N+  + +FR+   A++T + +   +  + G + +G
Sbjct:   15 LLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMK-ISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLG 138
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Match: Y63D3A.8 (pep chromosome:WBcel235:I:14114194:14118650:1 gene:WBGene00013407.1 transcript:Y63D3A.8.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y63D3A.8)

HSP 1 Score: 115.161 bits (287), Expect = 1.816e-29
Identity = 68/242 (28.10%), Postives = 116/242 (47.93%), Query Frame = 3 
Query:  135 NYFGPPQMLIKANSNENHKMSKSKRF---------WKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQ 833
            N   PP+   +A      +     R          W+  N   SLFHS++SG +A       + +  DL+N      + LV  S GY  HD  D++ N    +  EL+ HH ++   F +++F   F+G  +  LL+E+NSIFLH R LL   G +K    +RI  +LN+ +   FR+   A++  ++V++  ++ +    I  + +A +   N +L YR++ +D +    R RR    T +
Sbjct:   70 NTENPPENEAEAGEQVEQEPEPDSRDLSAIPPNKKWRISNECVSLFHSVISGLWAAYALLYYKQLVQDLVNYRCDVAINLVLMSAGYLFHDLVDLLVNEQSARIIELLFHHVVVLSAFAVTMFFNRFLGVVVFGLLMELNSIFLHSRSLLNLYGVDKKSPSFRIIALLNMVTLFAFRLCVSAYLVYFVVVSIPDLEWYVSIINGLVIASLASTNTVLTYRLLAADGLLGSRRTRRTPAATAE 311
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Match: K12H6.6 (pep chromosome:WBcel235:II:2828594:2831233:-1 gene:WBGene00019686.1 transcript:K12H6.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K12H6.6)

HSP 1 Score: 98.5969 bits (244), Expect = 1.288e-23
Identity = 66/221 (29.86%), Postives = 114/221 (51.58%), Query Frame = 3 
Query:  162 IKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLM--NIILFYRIIYSDFIKSVSRQRRIQ 818
            +  +   N  MS  K+ W+  N   S+ HS +SG +A      + ++    I  +      LV    GY ++D  D+I N    +  EL+ HH ++   F I +F  L +G  +  LL+E+NSIFLH+R L+   GF+K    +R+  ILNI + +VFR++   +M  ++  + S     +Y   ++ + I+ L   N++L YR++ +D     SRQR++ 
Sbjct:   62 VAESEPGNATMSTLKK-WRISNESVSMVHSAISGFWAAYALIVDPELFKSPILYHCIVGRNLVLMMTGYLLNDLVDLICNERSVRIVELLFHHVVVLSAFTICLFYDLMLGIVVAGLLMELNSIFLHIRSLMNLYGFDKKLTAFRVTVILNIITLVVFRLIVNVYMIYFVFASFSMSP--WYIASTICVLILCLASSNMVLTYRLLAADGFCGASRQRQVP 279
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Match: F41H10.5 (pep chromosome:WBcel235:IV:5360891:5362161:1 gene:WBGene00018318.1 transcript:F41H10.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F41H10.5)

HSP 1 Score: 80.8777 bits (198), Expect = 1.809e-17
Identity = 65/220 (29.55%), Postives = 102/220 (46.36%), Query Frame = 3 
Query:  189 KMSKSKRFWKYKNVLGSLFHSILSGTFAL-LCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKS-DCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSN 842
            K    KR+ + +N+     H+++ G   L L F    +I  D+I+ Y      L   S+ YF  DAFDM+       + EL++HH            +  F   A  ALL+EVNSIFLH R +L   G +      +R+    NI SF  FR+++    T W + N   + + Y  +G  G  I   +N +LF R++ SD    ++ + R +    +D N
Sbjct:   52 KFEGFKRY-RLQNLTVCWLHAVIVGGGDLILMFSHPHEIFHDVIDWYNPIAAQLPLISVAYFFQDAFDMLMYEWNSYTLELLLHHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGLSTQFPGVFRVVVYSNIISFFFFRIVSQILWTNWAIYNVPGLHWYYVLVGLGGPIIFGCINGMLFLRLLASD--GFLTEKLRARFAMTRDKN 268
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Match: M02B1.3 (pep chromosome:WBcel235:IV:12836510:12840674:1 gene:WBGene00010828.1 transcript:M02B1.3a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:M02B1.3)

HSP 1 Score: 77.411 bits (189), Expect = 5.372e-16
Identity = 66/222 (29.73%), Postives = 110/222 (49.55%), Query Frame = 3 
Query:  225 NVLGSLFHSILSGT--FALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYE-LVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLL--------GFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSD--FIKSVSRQRRIQIITVQDSNFNS 851
            N+  SL HS +SG   FA  C Y  + + +  ++ YT     +++ S+GYF +D  D++ N     S   L+ HH         +V S+ F+ YA  A+L+EV+SIFLH R +L          +GF+K      + + LN+ +F+VFR     ++  W  +N  ++ F +  I   G     ++N+ L  RI++SD   + SV  Q R+  +   +   NS
Sbjct:   91 NLTTSLIHSTISGLYLFAFFC-YNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFSK------VVSYLNLITFIVFRGFVQFFLFGWAWVNYDHIHFIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLSSVVSQDRLDALLEDNEYSNS 305
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Match: M02B1.3 (pep chromosome:WBcel235:IV:12836510:12840411:1 gene:WBGene00010828.1 transcript:M02B1.3a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:M02B1.3)

HSP 1 Score: 77.411 bits (189), Expect = 5.372e-16
Identity = 66/222 (29.73%), Postives = 110/222 (49.55%), Query Frame = 3 
Query:  225 NVLGSLFHSILSGT--FALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYE-LVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLL--------GFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSD--FIKSVSRQRRIQIITVQDSNFNS 851
            N+  SL HS +SG   FA  C Y  + + +  ++ YT     +++ S+GYF +D  D++ N     S   L+ HH         +V S+ F+ YA  A+L+EV+SIFLH R +L          +GF+K      + + LN+ +F+VFR     ++  W  +N  ++ F +  I   G     ++N+ L  RI++SD   + SV  Q R+  +   +   NS
Sbjct:   91 NLTTSLIHSTISGLYLFAFFC-YNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFSK------VVSYLNLITFIVFRGFVQFFLFGWAWVNYDHIHFIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLSSVVSQDRLDALLEDNEYSNS 305
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Zebrafish
Match: tlcd2 (TLC domain containing 2 [Source:NCBI gene;Acc:559420])

HSP 1 Score: 202.986 bits (515), Expect = 4.994e-64
Identity = 101/223 (45.29%), Postives = 153/223 (68.61%), Query Frame = 3 
Query:  126 QIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            +++NY G  ++ I   +  N         WK+ N+  S  HS+++G +++LCF  +  +  DLI T++     LVS S+GYFI+D  DM+ N     S+EL+ HH ++  CFGISV +  ++G+A+VALLVE+NS+FLH+RQ+L      KS   YR+N+++N+G+++VFR+ TLAWMTRWLV+NR  +    YTIGSVG+AI+T MNI+LFYR++ SDF+K+
Sbjct:   18 KLVNY-GLGKLPIPETARRNA--------WKWNNISTSFVHSLITGVWSVLCFCMHPQMAEDLIETHSVFSHALVSVSIGYFIYDFLDMVINQKIIHSWELLFHHVVVITCFGISVLTCRYVGFAVVALLVEINSVFLHLRQVLRMANLAKSTF-YRVNSMINLGTYVVFRINTLAWMTRWLVLNRDLIPLFSYTIGSVGLAIMTAMNIVLFYRLMRSDFMKA 230
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Zebrafish
Match: tlcd1 (TLC domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-041010-173])

HSP 1 Score: 137.117 bits (344), Expect = 2.021e-38
Identity = 82/253 (32.41%), Postives = 140/253 (55.34%), Query Frame = 3 
Query:   60 EMINFMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQ 818
            E+  F V+  +C S L F +++  +     P  + K             + WK++N+  SL HS+L+GT+A+ C      +  ++ +TYT    +LV  S GYFI DA D++ +   + S+E ++HH ++  CF  +VF+  ++  A+VAL VEVNS+FLH R LL       S   Y +N +LN+ +++ FR+    ++T +L  + S++ +  Y +  + M ++ +M +I FYR+I SDF      +RRIQ
Sbjct:    7 EVQKFPVLYVLCCSVL-FRILHWCLQIVARPDTVTK----------DRWKTWKWRNLSVSLVHSLLTGTWAVACVIYYPAMVHEIHSTYTPSAYMLVVVSSGYFIEDAADIVFSGHAKASWEFLLHHVLVLWCFLYAVFTHQYVAGAVVALFVEVNSVFLHTRLLLNLAKVAHSSLIYTVNKVLNVVTYVTFRLGAQFYLTWYLTYHYSSLDYALYFL--ITMMLMNIMILIYFYRLIRSDFFT----KRRIQ 242
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Xenopus
Match: TLCD2 (TLC domain containing 2 [Source:NCBI gene;Acc:100497270])

HSP 1 Score: 224.172 bits (570), Expect = 2.692e-72
Identity = 112/246 (45.53%), Postives = 167/246 (67.89%), Query Frame = 3 
Query:   75 MVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRR 812
            M + T+  SF  F ++N+ ++   PP              S  +  WK+ N+  S  HS+++G++ALL FY + ++  DLI+T++     LV+ S+GYFIHD  DM++N    QS+EL+ HH+++  CFGISV    ++G+A+VALLVE+NSIFLH+RQ+L      K+   YR+N++LN+G++++FR+ TLAWMTRWLV+NR N+    YTIGSVGMAI+T+MNIILF R++ SDF+KS    +R
Sbjct:    1 MELVTVGASFAFFRLLNRELHRLVPP------------PSSALRNPWKWGNIWTSFVHSLITGSWALLGFYLHPEMAEDLISTHSLFSHSLVAVSIGYFIHDFLDMLQNQKLHQSWELLFHHTVVITCFGISVVLHHYVGFAVVALLVEINSIFLHLRQILLMANLLKTTF-YRLNSLLNLGTYVIFRISTLAWMTRWLVLNRDNIPLVIYTIGSVGMAIMTVMNIILFCRLLRSDFLKSTREPQR 233
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Match: Tlcd1 (TLC domain containing 1 [Source:MGI Symbol;Acc:MGI:1915572])

HSP 1 Score: 115.546 bits (288), Expect = 2.639e-30
Identity = 67/221 (30.32%), Postives = 123/221 (55.66%), Query Frame = 3 
Query:  174 SNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSD-CKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFI--KSVSRQRRIQIIT 827
                H  +   R W++ N+L S  HSI+SG +ALLC +Q  ++  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F + F+G  ++ LLVEV++IFL +R ++     N  D   Y++N  +N+  + +FR+   A++T++ +      + G  T     + ++ LM II F R++ SDF   ++  RQ++ + +T
Sbjct:   30 PQPAHVQTDPLRTWRWHNLLVSFTHSIVSGIWALLCLWQTPEMLVEIETAWSASGYLLVCFSAGYFIHDTVDIVVSKQTRASWEYLVHHVMAMGAFFSGIFWKRFVGGGVLTLLVEVSNIFLTLRMMMKI--NNAQDLLLYKVNKYINLVMYFLFRLAPQAYLTKFFLQYAGQRTLG--TFLLAILLMLDLMIIIYFSRLLRSDFCPERAPRRQQKDKFLT 246
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Match: Tlcd2 (TLC domain containing 2 [Source:MGI Symbol;Acc:MGI:1917141])

HSP 1 Score: 110.538 bits (275), Expect = 8.513e-28
Identity = 62/194 (31.96%), Postives = 112/194 (57.73%), Query Frame = 3 
Query:  213 WKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            W ++N+  SL HS+LSG  AL+  +Q   + +D IN +     +LV+ S+GYF  D  DM+ N +  Q+++L+ HH  +  C   +V S  ++G+++V+LL+E+NSI LH+R+LL       S   +R+++  ++ + ++FR+L L WM+ WL      +S     +   G+  +  ++I    RI+  D ++S
Sbjct:   36 WMWRNIFVSLIHSLLSGVGALVGLWQFPQMVTDPINDHPPWARVLVAVSVGYFAADGVDMLWNQTLAQAWDLLCHHLAVVSCLSTAVVSGHYVGFSMVSLLLELNSICLHLRKLLLLSHKAPS-LAFRVSSWASLATLVLFRLLPLGWMSLWLSRQHYQLSLALVLLCVAGLVTVGSISISTGIRILTKDILQS 228
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Match: Tlcd1 (TLC domain containing 1 [Source:MGI Symbol;Acc:MGI:1915572])

HSP 1 Score: 97.0561 bits (240), Expect = 1.434e-23
Identity = 63/223 (28.25%), Postives = 114/223 (51.12%), Query Frame = 3 
Query:  174 SNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGS---VGMAIITLMNIILFYRIIYSDFI--KSVSRQRRIQIIT 827
                H  +   R W++ N+L S  HSI+SG +ALLC +Q  ++  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F + F+G  ++ LLVEV++IFL +R ++            +INN  ++   L+++                    G  T+G+     + ++ LM II F R++ SDF   ++  RQ++ + +T
Sbjct:   30 PQPAHVQTDPLRTWRWHNLLVSFTHSIVSGIWALLCLWQTPEMLVEIETAWSASGYLLVCFSAGYFIHDTVDIVVSKQTRASWEYLVHHVMAMGAFFSGIFWKRFVGGGVLTLLVEVSNIFLTLRMMM------------KINNAQDL---LLYKYA------------------GQRTLGTFLLAILLMLDLMIIIYFSRLLRSDFCPERAPRRQQKDKFLT 219
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Match: Tlcd2 (TLC domain containing 2 [Source:MGI Symbol;Acc:MGI:1917141])

HSP 1 Score: 87.4261 bits (215), Expect = 3.130e-20
Identity = 45/119 (37.82%), Postives = 73/119 (61.34%), Query Frame = 3 
Query:  189 KMSKSKR-FWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLH 542
               KS R  W ++N+  SL HS+LSG  AL+  +Q   + +D IN +     +LV+ S+GYF  D  DM+ N +  Q+++L+ HH  +  C   +V S  ++G+++V+LL+E+NSI LH
Sbjct:   27 PTPKSVRDRWMWRNIFVSLIHSLLSGVGALVGLWQFPQMVTDPINDHPPWARVLVAVSVGYFAADGVDMLWNQTLAQAWDLLCHHLAVVSCLSTAVVSGHYVGFSMVSLLLELNSICLH 145
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Match: Tlcd1 (TLC domain containing 1 [Source:MGI Symbol;Acc:MGI:1915572])

HSP 1 Score: 84.3445 bits (207), Expect = 9.783e-19
Identity = 52/184 (28.26%), Postives = 102/184 (55.43%), Query Frame = 3 
Query:  285 YQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSD-CKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFI--KSVSRQRRIQIIT 827
            +Q  ++  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F + F+G  ++ LLVEV++IFL +R ++     N  D   Y++N  +N+  + +FR+   A++T++ +      + G  T     + ++ LM II F R++ SDF   ++  RQ++ + +T
Sbjct:   50 WQTPEMLVEIETAWSASGYLLVCFSAGYFIHDTVDIVVSKQTRASWEYLVHHVMAMGAFFSGIFWKRFVGGGVLTLLVEVSNIFLTLRMMMKI--NNAQDLLLYKVNKYINLVMYFLFRLAPQAYLTKFFLQYAGQRTLG--TFLLAILLMLDLMIIIYFSRLLRSDFCPERAPRRQQKDKFLT 229
[Close]
BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|A8WGS4|TLCD2_DANRE (TLC domain-containing protein 2 OS=Danio rerio OX=7955 GN=tlcd2 PE=2 SV=1)

HSP 1 Score: 202.986 bits (515), Expect = 3.770e-63
Identity = 101/223 (45.29%), Postives = 153/223 (68.61%), Query Frame = 3 
Query:  126 QIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            +++NY G  ++ I   +  N         WK+ N+  S  HS+++G +++LCF  +  +  DLI T++     LVS S+GYFI+D  DM+ N     S+EL+ HH ++  CFGISV +  ++G+A+VALLVE+NS+FLH+RQ+L      KS   YR+N+++N+G+++VFR+ TLAWMTRWLV+NR  +    YTIGSVG+AI+T MNI+LFYR++ SDF+K+
Sbjct:   18 KLVNY-GLGKLPIPETARRNA--------WKWNNISTSFVHSLITGVWSVLCFCMHPQMAEDLIETHSVFSHALVSVSIGYFIYDFLDMVINQKIIHSWELLFHHVVVITCFGISVLTCRYVGFAVVALLVEINSVFLHLRQVLRMANLAKSTF-YRVNSMINLGTYVVFRINTLAWMTRWLVLNRDLIPLFSYTIGSVGLAIMTAMNIVLFYRLMRSDFMKA 230
[Close]
BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|A6NGC4|TLCD2_HUMAN (TLC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TLCD2 PE=3 SV=3)

HSP 1 Score: 117.472 bits (293), Expect = 6.768e-30
Identity = 64/200 (32.00%), Postives = 119/200 (59.50%), Query Frame = 3 
Query:  195 SKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            S ++  W++ N+  SL HS+LSGT ALL       + +D I+ +    L+LV+ S+GYF+ D  D++ N +  ++++L+ HH ++  C   +V S  ++G+++V+LL+E+NS  LH+R+LL  L        + + +  ++ +  +FR++ L WM+ WL      V     T+G +G+  + +M+IIL  RI+ +D ++S
Sbjct:   31 SAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLL-LLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQS 229
[Close]
BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q5U2T1|TLCD1_RAT (TLC domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Tlcd1 PE=2 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 1.227e-29
Identity = 66/219 (30.14%), Postives = 125/219 (57.08%), Query Frame = 3 
Query:  180 ENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSD-CKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFI--KSVSRQRRIQIIT 827
              H  +   R W++ N+L S  HSI+SG +ALLC +Q  ++  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F + F+G  ++ LLVEV++IFL +R ++     N  D   Y++N  +N+  + +FR+   A++T++ +      + G + +  + M  + +M +I F R++ SDF   ++ SRQ++ + +T
Sbjct:   32 PAHVQTDPLRTWRWHNLLVSFTHSIVSGIWALLCIWQTPEMLVEIETAWSVCGYLLVCFSAGYFIHDTVDIVVSRQTRASWEYLVHHVMAMGAFFSGIFWKRFVGGGVLTLLVEVSNIFLTLRMMMKI--NNAQDILLYKVNKYVNLVMYFLFRLAPQAYLTKFFLQYAGQRTLGTFLLSILLM--LDVMILIYFSRLLRSDFCPERAPSRQQKDKFLT 246
[Close]
BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q99JT6|TLCD1_MOUSE (TLC domain-containing protein 1 OS=Mus musculus OX=10090 GN=Tlcd1 PE=2 SV=1)

HSP 1 Score: 115.546 bits (288), Expect = 1.846e-29
Identity = 67/221 (30.32%), Postives = 123/221 (55.66%), Query Frame = 3 
Query:  174 SNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSD-CKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFI--KSVSRQRRIQIIT 827
                H  +   R W++ N+L S  HSI+SG +ALLC +Q  ++  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F + F+G  ++ LLVEV++IFL +R ++     N  D   Y++N  +N+  + +FR+   A++T++ +      + G  T     + ++ LM II F R++ SDF   ++  RQ++ + +T
Sbjct:   30 PQPAHVQTDPLRTWRWHNLLVSFTHSIVSGIWALLCLWQTPEMLVEIETAWSASGYLLVCFSAGYFIHDTVDIVVSKQTRASWEYLVHHVMAMGAFFSGIFWKRFVGGGVLTLLVEVSNIFLTLRMMMKI--NNAQDLLLYKVNKYINLVMYFLFRLAPQAYLTKFFLQYAGQRTLG--TFLLAILLMLDLMIIIYFSRLLRSDFCPERAPRRQQKDKFLT 246
[Close]
BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q96CP7|TLCD1_HUMAN (TLC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TLCD1 PE=1 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 4.448e-29
Identity = 66/216 (30.56%), Postives = 121/216 (56.02%), Query Frame = 3 
Query:  186 HKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS--VSRQRRIQIIT 827
            H  +   R W++ N+L S  HSI+SG +ALLC +Q  D+  ++   ++    +LV FS GYFIHD  D++ +   + S+E ++HH +    F   +F   F+G  ++ LLVEV++IFL +R ++  +   +    YR+N  +N+  + +FR+   A++T + +   +  + G + +G + M  + +M II F R++ SDF       +Q + + +T
Sbjct:   34 HVRADPLRTWRWHNLLVSFAHSIVSGIWALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDIVASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMK-ISNAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLM--LDVMIIIYFSRLLRSDFCPEHVPKKQHKDKFLT 246
[Close]
BLAST of TLC domain-containing protein 2 vs. TrEMBL
Match: E9GYI4 (TLC domain-containing protein OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_231239 PE=4 SV=1)

HSP 1 Score: 231.876 bits (590), Expect = 6.192e-72
Identity = 110/224 (49.11%), Postives = 161/224 (71.88%), Query Frame = 3 
Query:  141 FGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRR 812
            F    +L++  +  +   S ++  WK++N   SL HSIL+G +A+LCFY +  +  DLI T++T   +LVS S+GYFI+D  DM+ N  ++ SYEL+IHH  + +CFG+S+ +RL+IGY++VALLVEVNSIFLH RQL+   G  + +  YR+N +LNIG+FL+FR+LTL WMTRWLV++R  V    YT+GSVG+A+I LM+I+LF+RI+ +DFI    R ++
Sbjct:   27 FALTHVLLRPLTPTSVLKSGAQTTWKWRNTCNSLVHSILTGIWAMLCFYWHPKMAEDLIGTHSTSSHLLVSVSVGYFIYDFMDMLLNHRKRSSYELMIHHFFVVLCFGLSMLTRLYIGYSVVALLVEVNSIFLHTRQLMIIKGSPRQNSGYRLNALLNIGTFLIFRILTLGWMTRWLVVHREEVPVFAYTLGSVGLAVIVLMSIVLFFRILDADFISKKGRNKK 250
[Close]
BLAST of TLC domain-containing protein 2 vs. TrEMBL
Match: A0A444T807 (TLC domain-containing protein 2 OS=Armadillidium vulgare OX=13347 GN=Avbf_11467 PE=4 SV=1)

HSP 1 Score: 231.491 bits (589), Expect = 6.994e-72
Identity = 115/244 (47.13%), Postives = 172/244 (70.49%), Query Frame = 3 
Query:   87 TICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQ 818
            +I +SF +F+++N+ +N+  P  +L         K  K K  WK+KN++ SL HS+++G +A++CF    ++  DLIN+Y+T   +LVSFS+GYF+HD  D+  N   + SYEL+IHH  + VCFG+S+ +  +IGYA+V+LLVE+NSIFLH RQL   +G  KSD  YR+N+++NI +F++FR+  L WMTRWLV++RS++S   YT+GSVG+A+I LMNI+LF RI  +DF    S +R+I 
Sbjct:   14 SIFVSFWIFFILNRTLNFILPKAVL---------KTDKEK--WKWKNIMISLIHSVVAGLWAVICFILFPEMAEDLINSYSTFAHMLVSFSVGYFLHDLMDLSLNYRNRSSYELIIHHCFVIVCFGLSIMTTFYIGYAVVSLLVEINSIFLHSRQLFNIVGTQKSDFTYRLNSLMNIFTFIIFRIAVLGWMTRWLVLHRSHLSLPVYTLGSVGLAVIILMNIVLFIRICSTDF----SNKRKID 242
[Close]
BLAST of TLC domain-containing protein 2 vs. TrEMBL
Match: A0A444TVR9 (TLC domain-containing protein 2 OS=Armadillidium vulgare OX=13347 GN=Avbf_03119 PE=4 SV=1)

HSP 1 Score: 232.261 bits (591), Expect = 1.018e-71
Identity = 115/244 (47.13%), Postives = 172/244 (70.49%), Query Frame = 3 
Query:   87 TICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQ 818
            +I +SF +F+++N+ +N+  P  +L         K  K K  WK+KN++ SL HS+++G +A++CF    ++  DLIN+Y+T   +LVSFS+GYF+HD  D+  N   + SYEL+IHH  + VCFG+S+ +  +IGYA+V+LLVE+NSIFLH RQL   +G  KSD  YR+N+++NI +F++FR+  L WMTRWLV++RS++S   YT+GSVG+A+I LMNI+LF RI  +DF    S +R+I 
Sbjct:   14 SIFVSFWIFFILNRTLNFILPKAVL---------KTDKEK--WKWKNIMISLIHSVVAGLWAVICFILFPEMAEDLINSYSTFAHMLVSFSVGYFLHDLMDLSLNYRNRSSYELIIHHCFVIVCFGLSIMTTFYIGYAVVSLLVEINSIFLHSRQLFNIVGTQKSDFTYRLNSLMNIFTFIIFRIAVLGWMTRWLVLHRSHLSLPVYTLGSVGLAVIILMNIVLFIRICSTDF----SNKRKID 242
[Close]
BLAST of TLC domain-containing protein 2 vs. TrEMBL
Match: A0A444V0X4 (TLC domain-containing protein 2 OS=Acipenser ruthenus OX=7906 GN=EOD39_18440 PE=4 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 2.195e-70
Identity = 111/238 (46.64%), Postives = 165/238 (69.33%), Query Frame = 3 
Query:   99 SFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRR 812
            SF  F +VN++ +    P+             S  +  WK+KN+  SL HS+++G +A+LCFY + ++  DLI T++     L+S S+GYFIHD  DMI++    QS+EL+ HH+++  CFG+SV  R +IG+A+VALLVE+NSIFLH+RQ+L     + S   YR+N++LN+G+++VFR+ TLAWMTRWLV+NR NV    YT+GS+GMA++T MNI+LFYR++ SDF+KS    ++
Sbjct:   13 SFGFFNIVNKVFDRLPVPE-------------SALRNTWKWKNISTSLVHSLITGIWAVLCFYVHPEMAEDLIYTHSGFSHTLISVSIGYFIHDFVDMIRSQKLHQSWELLFHHTVVITCFGMSVLLRQYIGFAVVALLVEINSIFLHLRQILLMASLSTSTL-YRLNSMLNLGTYVVFRINTLAWMTRWLVLNRDNVPLLSYTVGSLGMAVMTAMNIVLFYRLLRSDFLKSSREGKK 236
[Close]
BLAST of TLC domain-containing protein 2 vs. TrEMBL
Match: A0A4W3JLL4 (TLC domain-containing protein OS=Callorhinchus milii OX=7868 GN=tlcd2 PE=4 SV=1)

HSP 1 Score: 227.254 bits (578), Expect = 3.583e-70
Identity = 115/248 (46.37%), Postives = 171/248 (68.95%), Query Frame = 3 
Query:   72 FMVIGTICLSFLMFYVVNQIINYFGP-PQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRR 812
             +++GT   SF+ F ++N+ + +  P P+             S ++  WK++N+  SL HS+++G +A+LCFY    +  DLI T++     LVS S+GYFI+D  DM+ N   Q S+EL+ HHS++  CFGISV    ++G+A+VALLVE+NS+FLH+RQ+L  +   +S   +R+N+I+N+G+++VFR+ TLAWMTRWLV+NR NV    YTIGSVGMAI+TLMNI+LFYR++ SDF+KS    +R
Sbjct:   11 LLIVGT---SFVGFKLLNRAVEHHLPVPE-------------SATRNRWKWRNICTSLAHSVVTGIWAVLCFYFQPQMAEDLIATHSAFSHALVSVSIGYFINDFVDMLCNQKLQNSWELLFHHSVVITCFGISVMLYSYVGFAVVALLVEINSVFLHLRQILLMINLRQSTL-FRVNSIINLGTYVVFRINTLAWMTRWLVLNRDNVPLVTYTIGSVGMAIMTLMNIVLFYRLLRSDFLKSSREIKR 241
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Cavefish
Match: tlcd2 (TLC domain-containing protein 2 [Source:NCBI gene;Acc:103028751])

HSP 1 Score: 214.157 bits (544), Expect = 2.049e-68
Identity = 99/200 (49.50%), Postives = 149/200 (74.50%), Query Frame = 3 
Query:  195 SKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKS 794
            +  +  WK++N+  S  HS+++G +A+LCFY +  +  DLI T++     LVS S+GYFI+D  DM+ N    QS+EL+ HH ++  CFG+SV +  +IG+A+VALLVE+NSIFLH+RQ+L     +KS   YR+N+++N+G+++VFR+ TLAWMTRWLV+NR  +    YT+GSVG+AI+T+MNI+LFYR++ +DF+KS
Sbjct:   32 TAQRNTWKWRNICTSFIHSLITGVWAVLCFYMHPQMAEDLIETHSVFSHALVSVSIGYFIYDFLDMVLNQKIYQSWELLFHHVVVITCFGLSVLTCRYIGFAVVALLVEINSIFLHLRQMLRMANVSKSTF-YRVNSMINLGTYVVFRINTLAWMTRWLVLNRDLIPLLSYTVGSVGLAIMTVMNIVLFYRLLRTDFLKS 230
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Cavefish
Match: TLCD1 (calfacilitin-like [Source:NCBI gene;Acc:103023685])

HSP 1 Score: 115.161 bits (287), Expect = 4.418e-30
Identity = 69/239 (28.87%), Postives = 134/239 (56.07%), Query Frame = 3 
Query:  105 LMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQI 821
            LMF VV++++     P+ +               R WK++N+  SL H++L+G +A+ C     ++ S++ + YT    +L+  S GYF+ D  D++ +   + S+E ++HH ++  CF  S++++ ++   ++ALLVE+NS+ LH R LL   G   S   Y  N +LN+ +++ FR+    +++ +L+ N S +   YY +  V + ++  M +I FYR++ +DF      +R++Q+
Sbjct:   23 LMFRVVHRLLRCLPAPKAV----------QLDEVRCWKWRNLCVSLVHAMLTGPWAVTCVCLWPEMLSNIHSYYTPMSYLLLCVSTGYFLQDTGDILLSGHARGSWEFLLHHFLVLWCFLYSLYTQRYVSGMVIALLVELNSVTLHARLLLKLAGAQASQL-YHTNKLLNLFTYITFRLSAQFYLSWYLLKNLSWLDHSYYFL--VTVVLMNTMILIYFYRLLRADFFP----RRKLQL 244
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Cavefish
Match: tlcd1 (TLC domain containing 1 [Source:NCBI gene;Acc:103044061])

HSP 1 Score: 113.235 bits (282), Expect = 2.001e-29
Identity = 71/240 (29.58%), Postives = 138/240 (57.50%), Query Frame = 3 
Query:   99 SFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQ 818
            S L F ++++++     P+ L      +N     S + W+++N+  SL HS+LSG +A+ C  Q   +  DL +++T    +LV  S GYFI DA D+I +   ++S+E +IHH ++   F  ++ + +++  A++AL VEVNS+FLH+R LL   G  +    Y +N ++N+ +++ FR+    +++ +++ N S +    + +  V M ++ +M ++ FYR++ +DF    S Q  ++
Sbjct:   19 SVLAFRLIHRLLKTLPRPRTL------DN----NSWKSWRWENLSVSLVHSLLSGAWAVFCVLQYPLMVHDLHSSFTPLAYLLVVISTGYFIQDAGDIIFSGHARESWEFLIHHVLVISTFMYALITSVYVAGAVIALFVEVNSVFLHLRLLLKLAGVPRDSLLYTVNKLINVATYISFRLGAQFYLSWYIIYNYSWLDHALFFL--VCMMLMNIMILVYFYRLLQTDFFTPRSHQNGVR 246
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Sea Lamprey
Match: tlcd1 (TLC domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-041010-173])

HSP 1 Score: 98.5969 bits (244), Expect = 2.270e-25
Identity = 55/174 (31.61%), Postives = 101/174 (58.05%), Query Frame = 3 
Query:  294 EDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCK-YRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIIL---FYRIIYSDFIKSVSR 803
             ++ +DL  +YT    +L++ S GYF+ D  D++ +   + S+E + HH+++  CFG S+ +R ++    VALLVEVNS+FLH R L+   G N    + YR+N  LN  ++++FR+   A++T ++++    +    +        ++ LMNII+   FYR++ +DF   + +
Sbjct:    5 PEVLTDL-TSYTLPMNVLLAISTGYFLQDTLDIVWSGQVKASWEFLFHHALVLSCFGYSLLTRQYVAGTTVALLVEVNSVFLHARLLMKLAGANAGCSRAYRLNRYLNAFTYVIFRLGAQAYLTAYVIVQWQLLMHPLFFC-----IVLNLMNIIMLIYFYRLLLTDFCPRLKQ 172
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Nematostella
Match: EDO35196 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM93])

HSP 1 Score: 141.354 bits (355), Expect = 1.557e-40
Identity = 80/241 (33.20%), Postives = 134/241 (55.60%), Query Frame = 3 
Query:   87 TICLSFLMFYVVNQIIN-YFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQ 806
             I LSFL+F  ++ I++ Y   P  ++             ++ W Y N+  SL HS ++  ++L CFY    + SD+I  +T+    L+  S GYF+HD  DM+ N    +S  L+IHH+++ V F I++ ++ + GY   +LL+EVNS+FLH R+++ F   ++    Y +N +L + +F+ FR LT AWM  +++  R  +   +   G   MA + +MNI LF ++  +DF K   RQ
Sbjct:   13 PISLSFLLFRGLHAILSKYIALPNSIVHG---------PRRKQWLYYNISISLIHSTVTAIWSLYCFYNEPAMLSDMIGVWTSSSYFLLCLSTGYFLHDFLDMLLND-LSRSTVLLIHHTLVVVAFLIAILTKNYCGYGTCSLLMEVNSVFLHSRRIMLFHDVDRKSTLYELNGLLMLATFVFFRFLTSAWMMNFVIKARHIIPATHVFYGGFAMAAMIIMNIQLFTQLWNADFAKDKKRQ 243
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Medaka
Match: tlcd2 (TLC domain containing 2 [Source:NCBI gene;Acc:101172260])

HSP 1 Score: 211.846 bits (538), Expect = 1.087e-67
Identity = 101/212 (47.64%), Postives = 151/212 (71.23%), Query Frame = 3 
Query:  189 KMSKSKR--FWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQ 818
             M +S R   WK++N+  S  HS ++  +A+LCF+ +  +  DLI T++     LVSFS+GYFI+D  DM+ +    QS+EL+ HH ++  CFG+SV S  ++G+A+VALLVE+NS+FLH+RQ+L       S   YR+N+++N+G+++VFR+ TLAWMTRWLV+NR  V    YT+GSVGMAI+T MNI+LF R++ SDF+KS +R+ + +
Sbjct:   28 PMPESARRNAWKWRNISTSFVHSFITAIWAVLCFFLHPQMAEDLIETFSWFSHALVSFSIGYFIYDFLDMVVHQKLSQSWELLFHHIVVITCFGLSVLSNRYLGFAVVALLVEINSVFLHLRQILRMASM-ASGTLYRVNSMINLGTYVVFRINTLAWMTRWLVLNRDKVPLLAYTLGSVGMAIMTAMNIVLFCRLLRSDFLKSSTRETKKE 238
[Close]
BLAST of TLC domain-containing protein 2 vs. Ensembl Medaka
Match: tlcd1 (TLC domain containing 1 [Source:NCBI gene;Acc:101163189])

HSP 1 Score: 120.939 bits (302), Expect = 2.582e-32
Identity = 66/193 (34.20%), Postives = 118/193 (61.14%), Query Frame = 3 
Query:  207 RFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDF 785
            R WK+KN+  S+ HS+L+  +AL CF  + ++ S++ +  T    +LV  S GYF+ DA D+I     + S+E ++HH+++  CF  ++++ LFI  A++AL VEVNSI LH+R +L  L   +    Y +N  +N+ +++ FR+    ++T +L  N S++    Y + S+   ++ +M +I FYR++ +DF
Sbjct:   45 RSWKWKNLSVSMVHSVLTAAWALTCFVVSPELLSNIRSYNTPLSYLLVCISTGYFVQDAADIILTGHAKGSWEFLLHHAVVIWCFLYTLYTHLFIAGAVIALFVEVNSITLHLRLMLK-LASAQDSSLYYVNKFVNLITYVTFRLSAQFYLTWYLTSNYSSLEHSGYFLTSI--MVMNIMILIYFYRLLRADF 234
[Close]
BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000060101.1 (SMESG000060101.1)

HSP 1 Score: 528.48 bits (1360), Expect = 0.000e+0
Identity = 262/263 (99.62%), Postives = 262/263 (99.62%), Query Frame = 3 
Query:   63 MINFMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 851
            MINFMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNE HKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS
Sbjct:    1 MINFMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNEKHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 263
[Close]
BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000060101.1 (SMESG000060101.1)

HSP 1 Score: 520.39 bits (1339), Expect = 0.000e+0
Identity = 258/259 (99.61%), Postives = 258/259 (99.61%), Query Frame = 3 
Query:   75 MVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 851
            MVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNE HKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS
Sbjct:    1 MVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNEKHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 259
[Close]
BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000060101.1 (SMESG000060101.1)

HSP 1 Score: 499.975 bits (1286), Expect = 0.000e+0
Identity = 247/248 (99.60%), Postives = 247/248 (99.60%), Query Frame = 3 
Query:  108 MFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 851
            MFYVVNQIINYFGPPQMLIKANSNE HKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS
Sbjct:    1 MFYVVNQIINYFGPPQMLIKANSNEKHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRIQIITVQDSNFNS 248
[Close]
BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000026799.1 (SMESG000026799.1)

HSP 1 Score: 128.257 bits (321), Expect = 5.092e-35
Identity = 79/248 (31.85%), Postives = 131/248 (52.82%), Query Frame = 3 
Query:   72 FMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRI 815
            F+VIG        F+V+N++I YF  P  +     +E          WK+ N+L S  H+++ G++ LLCFY   ++  DL++   + C  L+ FS GYF++D  DMI N    + +EL +HH  +   F  ++ +   +GY +VALL EVNS FLH R+LL           YR   ++N+ +F +FR + L  +T  + +        Y+    + M I+ L+N ILF+ I+ +DF++   + + I
Sbjct:    2 FLVIGC-------FHVLNRVIGYFFIPIFIRSKGKDE---------IWKWCNLLMSWVHALIVGSWDLLCFYYYPELTDDLVDFKNSFCYYLIVFSTGYFLYDFADMIYNKKVLKMWELTLHHLAVISTFLYNLCTMTCVGYNVVALLCEVNSFFLHSRKLLQLYHVPFRHVGYRCVAVVNLITFAIFRGIALVTITYGMYVEEKLNDRFYFICLCISMTIMNLLNPILFWIILKNDFLRQFKKPKHI 233
[Close]
BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000026799.1 (SMESG000026799.1)

HSP 1 Score: 128.257 bits (321), Expect = 6.816e-35
Identity = 78/245 (31.84%), Postives = 130/245 (53.06%), Query Frame = 3 
Query:   81 IGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRFWKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSLGYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVALLVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMTRWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRRI 815
            IG + L    F+V+N++I YF  P  +     +E          WK+ N+L S  H+++ G++ LLCFY   ++  DL++   + C  L+ FS GYF++D  DMI N    + +EL +HH  +   F  ++ +   +GY +VALL EVNS FLH R+LL           YR   ++N+ +F +FR + L  +T  + +        Y+    + M I+ L+N ILF+ I+ +DF++   + + I
Sbjct:   16 IGAMFLVIGCFHVLNRVIGYFFIPIFIRSKGKDE---------IWKWCNLLMSWVHALIVGSWDLLCFYYYPELTDDLVDFKNSFCYYLIVFSTGYFLYDFADMIYNKKVLKMWELTLHHLAVISTFLYNLCTMTCVGYNVVALLCEVNSFFLHSRKLLQLYHVPFRHVGYRCVAVVNLITFAIFRGIALVTITYGMYVEEKLNDRFYFICLCISMTIMNLLNPILFWIILKNDFLRQFKKPKHI 251
The following BLAST results are available for this feature:
BLAST of TLC domain-containing protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TLCD21.409e-3032.00TLC domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TLCD21.409e-3032.00TLC domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TLCD19.262e-3030.56TLC domain containing 1 [Source:HGNC Symbol;Acc:HG... [more]
TLCD14.494e-1927.87TLC domain containing 1 [Source:HGNC Symbol;Acc:HG... [more]
TLCD12.153e-1430.40TLC domain containing 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Y63D3A.81.816e-2928.10pep chromosome:WBcel235:I:14114194:14118650:1 gene... [more]
K12H6.61.288e-2329.86pep chromosome:WBcel235:II:2828594:2831233:-1 gene... [more]
F41H10.51.809e-1729.55pep chromosome:WBcel235:IV:5360891:5362161:1 gene:... [more]
M02B1.35.372e-1629.73pep chromosome:WBcel235:IV:12836510:12840674:1 gen... [more]
M02B1.35.372e-1629.73pep chromosome:WBcel235:IV:12836510:12840411:1 gen... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TLC domain-containing protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tlcd24.994e-6445.29TLC domain containing 2 [Source:NCBI gene;Acc:5594... [more]
tlcd12.021e-3832.41TLC domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
TLCD22.692e-7245.53TLC domain containing 2 [Source:NCBI gene;Acc:1004... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tlcd12.639e-3030.32TLC domain containing 1 [Source:MGI Symbol;Acc:MGI... [more]
Tlcd28.513e-2831.96TLC domain containing 2 [Source:MGI Symbol;Acc:MGI... [more]
Tlcd11.434e-2328.25TLC domain containing 1 [Source:MGI Symbol;Acc:MGI... [more]
Tlcd23.130e-2037.82TLC domain containing 2 [Source:MGI Symbol;Acc:MGI... [more]
Tlcd19.783e-1928.26TLC domain containing 1 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of TLC domain-containing protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A8WGS4|TLCD2_DANRE3.770e-6345.29TLC domain-containing protein 2 OS=Danio rerio OX=... [more]
sp|A6NGC4|TLCD2_HUMAN6.768e-3032.00TLC domain-containing protein 2 OS=Homo sapiens OX... [more]
sp|Q5U2T1|TLCD1_RAT1.227e-2930.14TLC domain-containing protein 1 OS=Rattus norvegic... [more]
sp|Q99JT6|TLCD1_MOUSE1.846e-2930.32TLC domain-containing protein 1 OS=Mus musculus OX... [more]
sp|Q96CP7|TLCD1_HUMAN4.448e-2930.56TLC domain-containing protein 1 OS=Homo sapiens OX... [more]
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BLAST of TLC domain-containing protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
E9GYI46.192e-7249.11TLC domain-containing protein OS=Daphnia pulex OX=... [more]
A0A444T8076.994e-7247.13TLC domain-containing protein 2 OS=Armadillidium v... [more]
A0A444TVR91.018e-7147.13TLC domain-containing protein 2 OS=Armadillidium v... [more]
A0A444V0X42.195e-7046.64TLC domain-containing protein 2 OS=Acipenser ruthe... [more]
A0A4W3JLL43.583e-7046.37TLC domain-containing protein OS=Callorhinchus mil... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tlcd22.049e-6849.50TLC domain-containing protein 2 [Source:NCBI gene;... [more]
TLCD14.418e-3028.87calfacilitin-like [Source:NCBI gene;Acc:103023685][more]
tlcd12.001e-2929.58TLC domain containing 1 [Source:NCBI gene;Acc:1030... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
tlcd12.270e-2531.61TLC domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TLC domain-containing protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO351961.557e-4033.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TLC domain-containing protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tlcd21.087e-6747.64TLC domain containing 2 [Source:NCBI gene;Acc:1011... [more]
tlcd12.582e-3234.20TLC domain containing 1 [Source:NCBI gene;Acc:1011... [more]
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BLAST of TLC domain-containing protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000060101.10.000e+099.62SMESG000060101.1[more]
SMESG000060101.10.000e+099.61SMESG000060101.1[more]
SMESG000060101.10.000e+099.60SMESG000060101.1[more]
SMESG000026799.15.092e-3531.85SMESG000026799.1[more]
SMESG000026799.16.816e-3531.84SMESG000026799.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023244 ID=SMED30023244|Name=TLC domain-containing protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=918bp
ATAGATAACCTTCGTAGATTTATAATAAATCAAATTATTATCATTTACTA
GTACTCTTGGAAATGATAAATTTTATGGTAATTGGTACGATTTGTCTAAG
TTTCCTAATGTTTTATGTTGTAAATCAAATAATCAATTATTTTGGACCAC
CGCAAATGTTGATTAAAGCTAATTCAAACGAAAACCATAAAATGTCTAAA
TCAAAAAGATTCTGGAAATATAAAAATGTTTTGGGATCTCTTTTCCATTC
CATACTAAGTGGAACATTTGCATTATTATGCTTTTATCAAAATGAAGATA
TTCGCAGTGATTTAATCAACACCTACACGACTGGATGTTTAATATTAGTT
TCATTTTCCCTGGGCTACTTCATTCACGATGCCTTCGACATGATTAAAAA
CAGTTCGGAACAACAATCGTACGAACTAGTAATCCATCATTCAATTATAT
TTGTCTGTTTCGGAATATCAGTTTTTAGTAGGCTCTTCATCGGATATGCT
CTGGTGGCATTATTGGTGGAAGTGAATTCCATATTCCTTCACATGCGGCA
ATTGCTCGGATTTTTAGGGTTCAATAAATCCGATTGTAAATACAGGATTA
ATAATATTTTAAACATTGGATCATTTTTAGTATTTCGAATGTTGACATTG
GCATGGATGACCCGGTGGCTGGTGATGAACAGGAGCAATGTCAGTTTTGG
CTATTATACAATAGGCAGTGTGGGCATGGCCATCATAACATTGATGAACA
TTATCCTTTTCTATAGAATTATTTATTCGGATTTCATAAAATCCGTGTCC
AGACAAAGGAGAATCCAAATAATTACAGTTCAAGATTCCAATTTTAACAG
TTGACAATTTTTATATTAGGAACCTTTATAGATCATAGAAAGTTTATTTT
GTATAAAATATAATGATA
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protein sequence of SMED30023244-orf-1

>SMED30023244-orf-1 ID=SMED30023244-orf-1|Name=SMED30023244-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=264bp
MINFMVIGTICLSFLMFYVVNQIINYFGPPQMLIKANSNENHKMSKSKRF
WKYKNVLGSLFHSILSGTFALLCFYQNEDIRSDLINTYTTGCLILVSFSL
GYFIHDAFDMIKNSSEQQSYELVIHHSIIFVCFGISVFSRLFIGYALVAL
LVEVNSIFLHMRQLLGFLGFNKSDCKYRINNILNIGSFLVFRMLTLAWMT
RWLVMNRSNVSFGYYTIGSVGMAIITLMNIILFYRIIYSDFIKSVSRQRR
IQIITVQDSNFNS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0002032epidermal cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR006634TLC-dom
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR006634TRAM/LAG1/CLN8 homology domainSMARTSM00724lag1_27coord: 48..245
e-value: 7.0E-27
score: 105.3
IPR006634TRAM/LAG1/CLN8 homology domainPFAMPF03798TRAM_LAG1_CLN8coord: 55..237
e-value: 3.0E-24
score: 85.9
IPR006634TRAM/LAG1/CLN8 homology domainPROSITEPS50922TLCcoord: 48..245
score: 26.472
NoneNo IPR availablePANTHERPTHR13439CT120 PROTEINcoord: 47..249
NoneNo IPR availablePANTHERPTHR13439:SF2TLC DOMAIN-CONTAINING PROTEIN 2coord: 47..249
NoneNo IPR availableTMHMMTMhelixcoord: 56..75
NoneNo IPR availableTMHMMTMhelixcoord: 212..234
NoneNo IPR availableTMHMMTMhelixcoord: 180..202
NoneNo IPR availableTMHMMTMhelixcoord: 82..104
NoneNo IPR availableTMHMMTMhelixcoord: 2..24
NoneNo IPR availableTMHMMTMhelixcoord: 137..159