2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

Overview


Name	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
Smed ID	SMED30023139
Length (bp)	1606

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (SMED30023139) t-SNE clustered cells

Violin plots show distribution of expression levels for 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (SMED30023139) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 (SMED30023139) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30023139

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30023139	SMESG000053951.1	SmedASXL_009643	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
cephalic ganglia	SMED30023139	SMESG000053951.1	dd_Smed_v4_9466_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30023139	SMESG000053951.1	dd_Smed_v4_9466_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30023139	SMESG000053951.1	dd_Smed_v4_9466_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30023139	SMESG000053951.1	Contig37667	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30023139	SMESG000053951.1	Contig37667	uc_Smed_v2	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
Match: OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25585])

HSP 1 Score: 237.269 bits (604), Expect = 1.046e-70
Identity = 159/452 (35.18%), Postives = 243/452 (53.76%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADESEVEGTDSKGEGPSSSKK-----------------RKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N  VFF+V+  S+HQV EV     S EK+R+SI+GWF GPS+        PP  R   +  +  ++++WI+  YL      +I+E F E+SE+ L +F   +K+ ++ + L+   +E+   GP N  + F    ++S+ P I++E  ++  SEA+ +LLS+ TGL  H    S++++  D+ E E TD   EG S S                    +T+   E  +  K SS+     ELRHWK G Y+L+ D  +   E  LDL    G       + + GGF SY A+GEDEE+ +V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISTLRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPN--KRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSK--AEFALDLILYCGC---EGWEPEYGGFTSYIAKGEDEELLTVN 494

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
Match: OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25585])

HSP 1 Score: 190.66 bits (483), Expect = 1.141e-53
Identity = 141/452 (31.19%), Postives = 219/452 (48.45%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADESEVEGTDSKGEGPSSS-----------------KKRKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N  VFF+V+  S+HQ                                                 ++++WI+  YL      +I+E F E+SE+ L +F   +K+ ++ + L+   +E+   GP N  + F    ++S+ P I++E  ++  SEA+ +LLS+ TGL  H    S++++  D+ E E TD   EG S S                    +T+   E  +  K SS+     ELRHWK G Y+L+ D  +   E  LDL    G       + + GGF SY A+GEDEE+ +V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISTLRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQ-----------------------------------------------HEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPN--KRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSK--AEFALDLILYCGC---EGWEPEYGGFTSYIAKGEDEELLTVN 451

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
Match: OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25585])

HSP 1 Score: 123.635 bits (309), Expect = 2.278e-32
Identity = 73/181 (40.33%), Postives = 105/181 (58.01%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKAR 695
            ++PF    I NFI     F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N  VFF+V+  S+HQV EV     S EK+R
Sbjct:    3 MDPFLHCVIPNFIQ-SQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISTLRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPP-WDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEEKSR 175

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
Match: OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25585])

HSP 1 Score: 77.0258 bits (188), Expect = 6.721e-16
Identity = 44/112 (39.29%), Postives = 66/112 (58.93%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAF 488
            ++PF    I NFI   + F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF
Sbjct:   56 MDPFLHCVIPNFIQSQD-FLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISTLRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAF 164

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Celegans
Match: C17G10.1 (pep chromosome:WBcel235:II:5596560:5598449:1 gene:WBGene00015915.1 transcript:C17G10.1.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C17G10.1)

HSP 1 Score: 142.895 bits (359), Expect = 6.309e-37
Identity = 103/373 (27.61%), Postives = 193/373 (51.74%), Query Frame = 3

Query:   30 RKNSPMDSLSLNKKFLSNKF-DDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIK-LSDKSNDLYKFQQSKDFKLLK--KSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEE-NGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEAL-IHEWISEIYLSDQVVDEIRESFLENSEVQLVDF----FNEDKYNELL---KCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGS 1109
            R++  ++ + ++ K+L +KF  ++K   +K+             PF    + NF+   +   EKI +EL++ +    K NDLY   QS D K +   ++  +   R F  + +  W++  +G++L + ++D   S Y  +D LL H+D +E RR AFV+Y+ + DW+ E NGG L + + D+  +P+ V   F P +NSF+ F+V++ S+H+V E+      +E+ R+SINGWF           ++   +R  P   E A  + + IS+ YL  +  DE++++F ++SE+ L  F     +++ Y+EL+    C +++     GP++         +KS      + + + L S+    L + +TG+   G+
Sbjct:   22 RRSVVLEPIHISPKYLEDKFKTEFKKGFEKSNG-----------PFPHWQLRNFVDNSDNVVEKIEDELQNFEGWKRKENDLYSLYQSDDLKSINPVENPAVFSFRQFLYKEVKEWLQNVSGVELTE-QVDCNGSCYARTDSLLPHNDLIETRRFAFVYYITSADWDSEVNGGDLQLFNHDKKLQPTSVAAQFSPLRNSFMLFEVSEKSWHRVAEM-----LSEEPRLSINGWFHSTRRIEPKKPAVEAIQRFVP---EAACKLSKLISKEYLQKERQDEVQQTFADSSELNLSKFIFEEIHDNAYSELISNPSCFETV-----GPVSKRHVARLDEEKSADLQNTKRIIQCLKSKNFAKLAAKLTGVTVTGA 369

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Celegans
Match: C17G10.1 (pep chromosome:WBcel235:II:5596547:5598449:1 gene:WBGene00015915.1 transcript:C17G10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C17G10.1)

HSP 1 Score: 142.895 bits (359), Expect = 6.309e-37
Identity = 103/373 (27.61%), Postives = 193/373 (51.74%), Query Frame = 3

Query:   30 RKNSPMDSLSLNKKFLSNKF-DDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIK-LSDKSNDLYKFQQSKDFKLLK--KSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEE-NGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEAL-IHEWISEIYLSDQVVDEIRESFLENSEVQLVDF----FNEDKYNELL---KCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGS 1109
            R++  ++ + ++ K+L +KF  ++K   +K+             PF    + NF+   +   EKI +EL++ +    K NDLY   QS D K +   ++  +   R F  + +  W++  +G++L + ++D   S Y  +D LL H+D +E RR AFV+Y+ + DW+ E NGG L + + D+  +P+ V   F P +NSF+ F+V++ S+H+V E+      +E+ R+SINGWF           ++   +R  P   E A  + + IS+ YL  +  DE++++F ++SE+ L  F     +++ Y+EL+    C +++     GP++         +KS      + + + L S+    L + +TG+   G+
Sbjct:   22 RRSVVLEPIHISPKYLEDKFKTEFKKGFEKSNG-----------PFPHWQLRNFVDNSDNVVEKIEDELQNFEGWKRKENDLYSLYQSDDLKSINPVENPAVFSFRQFLYKEVKEWLQNVSGVELTE-QVDCNGSCYARTDSLLPHNDLIETRRFAFVYYITSADWDSEVNGGDLQLFNHDKKLQPTSVAAQFSPLRNSFMLFEVSEKSWHRVAEM-----LSEEPRLSINGWFHSTRRIEPKKPAVEAIQRFVP---EAACKLSKLISKEYLQKERQDEVQQTFADSSELNLSKFIFEEIHDNAYSELISNPSCFETV-----GPVSKRHVARLDEEKSADLQNTKRIIQCLKSKNFAKLAAKLTGVTVTGA 369

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Fly
Match: sud1 (gene:FBgn0265189 transcript:FBtr0339113)

HSP 1 Score: 151.754 bits (382), Expect = 1.650e-39
Identity = 119/440 (27.05%), Postives = 200/440 (45.45%), Query Frame = 3

Query:   69 KFLSNKFDDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNEL-KSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLV----NDDWNEENGGHLDIISTDESGEPS-RVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRG---PSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKY----NELLKCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPE 1349
            K+L   + + KS  Q  +E      ++  +PF +  +   +    G  + ++ E+ + ++ S K  DLY+F QS D   +   + L +      + + PW+++ T + L  + +  + S+Y   DYLL HDD L+ R++AF++YL      ++W +E GG L+I  +D+   P   V     PK N F FFKV   S+HQV EV     + +  R++INGWF G    +     + + P    L P  +    +  +++ +YL       I++   ENSE+ L +FF  +K+    ++LL   D+L++R  GP N       V D +     + E+ ++  S A+  LL D T L+  G+                   E P+ S                   +EL+ W  G Y++L DG     E  LDL Y +   E
Sbjct:   63 KWLQTAWTEEKS--QGTKETQTGAQVFS-DPFQICLLPGMLE--KGQSQALVAEIIQKVQWSRKQMDLYEFYQSADLSNMPACRLLTNFLQVLRKQVRPWLEKVTNLKL--DYVSASCSMYTCGDYLLVHDDLLKDRQVAFIYYLSPWEGAEEWTDEQGGCLEIFGSDDQCFPQFPVQRKIAPKDNQFAFFKVGSRSFHQVGEVT----TFDYPRLTINGWFHGDTNEAFVADSLRAFPRLNYLQPDGLNRPPLGLFLNNVYLKGATRRSIQKRIEENSEICLYEFFKREKFELARSQLLADSDTLKWRRQGPANAHN--YEVLDLTTARGTILELLQLFRSHAMFDLLRDFTDLDLAGTD-----------------AESPTCS-------------------VELQRWSHGNYTVLGDG-LTSEENTLDLVYYLNAAE 452

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Zebrafish
Match: ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-3294])

HSP 1 Score: 245.358 bits (625), Expect = 3.723e-74
Identity = 163/452 (36.06%), Postives = 244/452 (53.98%), Query Frame = 3

Query:   99 KSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADE--SEVEGTDSKGEGPSSSKKRKTELSSEVIQ--VGKLSSI-ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            + A QK   ++        EPF    I +F+  P+ F E +  EL  +  + KSNDLYKFQQS D K  +K   +  IRS        W+ E   +DL +  +DI+ + Y+ +D LLCHDD LE RR+AF+ YLV   W  ++GG LD+ +TDE  +P  V  S LP  NS VFF+V+  S+HQV EV     S EK R+S++GWF GPS+        P   R + +  +E L+ EW++E+YL  +    +++ F ++SE+ L  F  E+K  ++   L S  +++   GP N  +   +  D    P+ VQE   +L SEA  +LLS++TGL+ H   +++ + E +E  SE E  D++G+  +     + + SS   +   G  S + E+R W  G Y+LL D  +  RE  LDL   +G       K + GGF SY A  EDEE+ +V
Sbjct:   41 RDAWQKKRSFSNGCVQLDCEPFPHCQITDFLQSPS-FVEGLQAELLQLNFNSKSNDLYKFQQSDDLKE-RKEHHISQIRSIIFGEFRVWLSEVLQVDL-EATVDISCAKYEHTDVLLCHDDELEGRRVAFILYLV-PPWECKDGGTLDLFNTDEHCQPMSVVKSLLPCCNSLVFFEVSPVSFHQVAEVL----SEEKCRLSLSGWFHGPSLPRPSRYIEPSAPRHAHIPRDETLLFEWVNEMYLDPRYQARVQQEFEDSSEICLPSFLQEEKLRQVRSALQSSEIQWEKRGPPN--KRCYSCADLQSIPSCVQECWELLSSEAFFILLSNLTGLSLHYLCTNEDDGENEEGKSETENRDTEGDAQAGGSSTEADASSRENKKDKGPPSCVGEVRRWAHGDYTLLHDSVK--REYALDLQLHMGC---AGWKAEFGGFTSYIAHDEDEELLTV 477

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Xenopus
Match: ogfod1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:NCBI gene;Acc:549076])

HSP 1 Score: 225.713 bits (574), Expect = 3.751e-67
Identity = 143/397 (36.02%), Postives = 217/397 (54.66%), Query Frame = 3

Query:  255 KSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSS 1424
            KSNDLY+F+QS+D K  ++   ++ +R    +    W+   T ++L +  +D++ + Y  +D LLCHDD LE RR AF+ YLV  +W++ +GG LD+   D++G+P  +  S +P+ NS VFF+V+  S+HQV EV       EK R+S++GWF G S++       P P R   +  ++ +++EWI+  YLS +   +I+E F E SE+ L DF   +K+  +   L+  S+     GP N      A  D   FPA++     +L SEA  +LLS++TGL  H  +  N+E+DE         GEGPS       E ++ V Q G  S +     ELRHW+   Y+++ D D    E  LDL    G     D + + GGF SY A+ EDEEV +
Sbjct:   92 KSNDLYQFKQSEDLKN-RREPHIKALRQVLFEDFRQWLSNITNVEL-EKTVDVSCAQYGYTDALLCHDDELEGRRFAFILYLV-PEWSKSDGGSLDLYGMDDNGQPGPIVKSLIPRWNSLVFFEVSPVSFHQVSEVL----GDEKCRLSVSGWFHGCSLERPLRCLDPLPVRSPHIPHDDQILYEWINPAYLSLESQAQIQEEFEERSEILLKDFLKAEKFQAVCAALETQSITLEKCGPPNKRCYERAHGD---FPAVIGSCMELLRSEAFFLLLSNLTGLKLHFLASNNEESDE---------GEGPS-------EPNAGVPQQGASSEVPSCSGELRHWQHSYYTMIHDLDPERHEFALDLLLFCGC---DDWEAEYGGFTSYIAKEEDEEVKT 459

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Xenopus
Match: ogfod1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:NCBI gene;Acc:549076])

HSP 1 Score: 226.098 bits (575), Expect = 7.056e-67
Identity = 144/398 (36.18%), Postives = 218/398 (54.77%), Query Frame = 3

Query:  255 KSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            KSNDLY+F+QS+D K  ++   ++ +R    +    W+   T ++L +  +D++ + Y  +D LLCHDD LE RR AF+ YLV  +W++ +GG LD+   D++G+P  +  S +P+ NS VFF+V+  S+HQV EV       EK R+S++GWF G S++       P P R   +  ++ +++EWI+  YLS +   +I+E F E SE+ L DF   +K+  +   L+  S+     GP N      A  D   FPA++     +L SEA  +LLS++TGL  H  +  N+E+DE         GEGPS       E ++ V Q G  S +     ELRHW+   Y+++ D D    E  LDL    G     D + + GGF SY A+ EDEE+ SV
Sbjct:   92 KSNDLYQFKQSEDLKN-RREPHIKALRQVLFEDFRQWLSNITNVEL-EKTVDVSCAQYGYTDALLCHDDELEGRRFAFILYLV-PEWSKSDGGSLDLYGMDDNGQPGPIVKSLIPRWNSLVFFEVSPVSFHQVSEVL----GDEKCRLSVSGWFHGCSLERPLRCLDPLPVRSPHIPHDDQILYEWINPAYLSLESQAQIQEEFEERSEILLKDFLKAEKFQAVCAALETQSITLEKCGPPNKRCYERAHGD---FPAVIGSCMELLRSEAFFLLLSNLTGLKLHFLASNNEESDE---------GEGPS-------EPNAGVPQQGASSEVPSCSGELRHWQHSYYTMIHDLDPERHEFALDLLLFCGC---DDWEAEYGGFTSYIAKEEDEELLSV 460

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Mouse
Match: Ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:MGI Symbol;Acc:MGI:2442978])

HSP 1 Score: 229.565 bits (584), Expect = 4.172e-68
Identity = 158/455 (34.73%), Postives = 237/455 (52.09%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH------------GSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSE----------VIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI   + F E +  EL S+   +K NDLYKFQQS D K  +K   +  +R    +    W+ + +GIDL +  ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+ + GG LD+  TDE  +P ++  S +P  N  VFF+V+  S+HQV EV     S E +R+SI+GWF GPS+        PP  R   +  +  +++EWI+  YL      +I+E F E SE+ L +F   +K+ E+ + L+   +E++ HGP N  + F    +++  P +++E   +  SEA+ +LLS++TGL  H                +   A     EGT  +  GP +++      S E            +  K SS+     ELR WK G Y+L+ D  +   E  LDLF   G       + + GGF SY A+GEDEE+  V+
Sbjct:   43 MDPFLHCVIPNFIQSQD-FLEGLHKELLSLDFHEKYNDLYKFQQSDDLKN-RKEPHISALRKLMFEDFRAWLSKVSGIDL-EPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPN--KRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTK--TEFALDLFLYCGC---EGWEPEYGGFTSYIAKGEDEELLIVN 482

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Mouse
Match: Ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:MGI Symbol;Acc:MGI:2442978])

HSP 1 Score: 229.565 bits (584), Expect = 5.499e-68
Identity = 158/455 (34.73%), Postives = 236/455 (51.87%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH------------GSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSE----------VIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL S+   +K NDLYKFQQS D K  +K   +  +R    +    W+ + +GIDL +  ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+ + GG LD+  TDE  +P ++  S +P  N  VFF+V+  S+HQV EV     S E +R+SI+GWF GPS+        PP  R   +  +  +++EWI+  YL      +I+E F E SE+ L +F   +K+ E+ + L+   +E++ HGP N  + F    +++  P +++E   +  SEA+ +LLS++TGL  H                +   A     EGT  +  GP +++      S E            +  K SS+     ELR WK G Y+L+ D  +   E  LDLF   G       + + GGF SY A+GEDEE+  V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLHKELLSLDFHEKYNDLYKFQQSDDLKN-RKEPHISALRKLMFEDFRAWLSKVSGIDL-EPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPN--KRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTK--TEFALDLFLYCGC---EGWEPEYGGFTSYIAKGEDEELLIVN 497

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Mouse
Match: Ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:MGI Symbol;Acc:MGI:2442978])

HSP 1 Score: 185.267 bits (469), Expect = 9.975e-52
Identity = 141/455 (30.99%), Postives = 214/455 (47.03%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH------------GSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSE----------VIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI   + F E +  EL S+   +K NDLYKFQQS D K  +K   +  +R    +    W+ + +GIDL +  ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+ + GG LD+  TDE  +P ++  S +P  N  VFF+V+  S+HQ                                                 +++EWI+  YL      +I+E F E SE+ L +F   +K+ E+ + L+   +E++ HGP N  + F    +++  P +++E   +  SEA+ +LLS++TGL  H                +   A     EGT  +  GP +++      S E            +  K SS+     ELR WK G Y+L+ D  +   E  LDLF   G       + + GGF SY A+GEDEE+  V+
Sbjct:   58 MDPFLHCVIPNFIQSQD-FLEGLHKELLSLDFHEKYNDLYKFQQSDDLKN-RKEPHISALRKLMFEDFRAWLSKVSGIDL-EPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQ-----------------------------------------------HEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPN--KRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTK--TEFALDLFLYCGC---EGWEPEYGGFTSYIAKGEDEELLIVN 454

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q8N543|OGFD1_HUMAN (Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1)

HSP 1 Score: 237.269 bits (604), Expect = 5.023e-70
Identity = 159/452 (35.18%), Postives = 243/452 (53.76%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADESEVEGTDSKGEGPSSSKK-----------------RKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N  VFF+V+  S+HQV EV     S EK+R+SI+GWF GPS+        PP  R   +  +  ++++WI+  YL      +I+E F E+SE+ L +F   +K+ ++ + L+   +E+   GP N  + F    ++S+ P I++E  ++  SEA+ +LLS+ TGL  H    S++++  D+ E E TD   EG S S                    +T+   E  +  K SS+     ELRHWK G Y+L+ D  +   E  LDL    G       + + GGF SY A+GEDEE+ +V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISTLRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPN--KRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSK--AEFALDLILYCGC---EGWEPEYGGFTSYIAKGEDEELLTVN 494

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q5R4R3|OGFD1_PONAB (Prolyl 3-hydroxylase OGFOD1 OS=Pongo abelii OX=9601 GN=OGFOD1 PE=2 SV=1)

HSP 1 Score: 231.876 bits (590), Expect = 5.090e-68
Identity = 157/452 (34.73%), Postives = 241/452 (53.32%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADESEVEGTDSKGEGPSSSKK-----------------RKTELSSEVIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N  VFF+V+  S+HQV EV     S EK+R+SI+GWF GPS+        PP  R   +  +  ++++WI+  YL      +I+E F E+SE+ L +F   +K+ ++ + L+   +E+   GP N  + F    ++S+ P I++E  ++  SEA+ +LLS+ TGL  H    S++++  D+ E E  D   EG S S                    +T+   E  +  K SS+     ELR WK G Y+L+ D  +   E  LDL    G       + + GGF SY A+GEDEE+ +V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKK-RREPHISALRKILFEDFRSWLSDISKIDL-ESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PPWDRSLGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEEKSRLSISGWFHGPSLTRPPNHFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFMKVCEALEHGDVEWSSRGPPN--KRFYEKAEESKLPEILKECMKLFHSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAEAADITEEGTSHSPPEPENNQTAISNNSQQSNEQTDPEPEENETKKESSVPTCQGELRRWKTGHYTLIHDHSK--AEFALDLILYCGC---EGWEPEYGGFTSYIAKGEDEELLTVN 494

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q3MI03|OGFD1_BOVIN (Prolyl 3-hydroxylase OGFOD1 OS=Bos taurus OX=9913 GN=OGFOD1 PE=2 SV=2)

HSP 1 Score: 230.72 bits (587), Expect = 1.346e-67
Identity = 156/456 (34.21%), Postives = 241/456 (52.85%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--------------------------GSSQKNKEADESEVEGTDS--KGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI   N F E +  EL ++   +K NDLYKFQQS D K  ++   +  +R    +    W+ + + IDL ++ ID++ + Y+ SD LLCHDD LE RRIAF+ YLV   W+   GG LD+ S DE  +P ++  S +P  N+ VFF+V+  S+HQV EV     S EK+R+SI+GWF GPS+        P   R   +  +  ++++WI+  YL  +   +I+E F E+SE+ L +F   +K+ E+ + L+   +E+   GP N  + F    ++S+ P I+++   +  SEA+ +LLS+ TGL  H                          G+S  + E + S    +DS  + EGP+  ++ + +  S V         ELRHWK G Y+L+ D  +   E  LDL    G       + + GGF SY A+GEDEE+ +V+
Sbjct:   58 MDPFLHCVIPNFIQSQN-FLEGLQKELLNLDFHEKYNDLYKFQQSDDLKK-RREPHICALRKILFEHFRSWISDISKIDL-ESTIDMSCAKYEFSDALLCHDDELEGRRIAFILYLV-PPWDASLGGTLDLFSVDEHFQPKQIVKSLIPSWNTLVFFEVSPVSFHQVSEVL----SEEKSRLSISGWFHGPSLTRPPTYFEPLIARSPHIPQDHEILYDWINPTYLDMEYQAQIQEEFEESSEILLKEFLQPEKFAEVCEALERGRVEWSSRGPPN--KRFYEKAEESQLPDILRDCMALFRSEAMFLLLSNFTGLKLHFLAPSEDEPEDKKERDAVSAAENTEEGTSHSSSEPENSWAATSDSSLQSEGPTDPEEDEAKKESSVPTCQG----ELRHWKTGHYTLIHDNSK--TEFALDLLLYCGC---EGWEPEYGGFTSYIAKGEDEELLTVN 494

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q3U0K8|OGFD1_MOUSE (Prolyl 3-hydroxylase OGFOD1 OS=Mus musculus OX=10090 GN=Ogfod1 PE=1 SV=1)

HSP 1 Score: 229.565 bits (584), Expect = 3.846e-67
Identity = 158/455 (34.73%), Postives = 236/455 (51.87%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH------------GSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSE----------VIQVGKLSSI-----ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            ++PF    I NFI     F E +  EL S+   +K NDLYKFQQS D K  +K   +  +R    +    W+ + +GIDL +  ID++ + Y+ +D LLCHDD LE RRIAF+ YLV   W+ + GG LD+  TDE  +P ++  S +P  N  VFF+V+  S+HQV EV     S E +R+SI+GWF GPS+        PP  R   +  +  +++EWI+  YL      +I+E F E SE+ L +F   +K+ E+ + L+   +E++ HGP N  + F    +++  P +++E   +  SEA+ +LLS++TGL  H                +   A     EGT  +  GP +++      S E            +  K SS+     ELR WK G Y+L+ D  +   E  LDLF   G       + + GGF SY A+GEDEE+  V+
Sbjct:   58 MDPFLHCVIPNFIQS-QDFLEGLHKELLSLDFHEKYNDLYKFQQSDDLKN-RKEPHISALRKLMFEDFRAWLSKVSGIDL-EPTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLV-PSWDRDLGGTLDLYDTDEHLQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVL----SEETSRLSISGWFYGPSLTRPPTYFEPPIPRNPHIPQDHEILYEWINPAYLEMDYQMQIQEEFEERSEILLKEFLKPEKFAEVCEALEKGDVEWKSHGPPN--KRFYEKAEENNLPDVLKECMGLFRSEALFLLLSNLTGLKLHFLAPSEDDETEEKGEGETASAAAGTEEGTSRRPSGPENNQVAAGSHSQENGEQADPEAQEEEAKKESSVPMCQGELRRWKTGHYTLVHDNTK--TEFALDLFLYCGC---EGWEPEYGGFTSYIAKGEDEELLIVN 497

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Match: sp|Q6DE73|OGFD1_XENLA (Prolyl 3-hydroxylase OGFOD1 OS=Xenopus laevis OX=8355 GN=ogfod1 PE=2 SV=1)

HSP 1 Score: 228.024 bits (580), Expect = 6.535e-67
Identity = 159/449 (35.41%), Postives = 237/449 (52.78%), Query Frame = 3

Query:   90 DDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTE-LSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            D  K A + N+            PF  G I+ FI   + F E++  EL ++    KSNDLY+F+QS+D K  K+S  ++ +R    +    W+   T ++L +  +DI+ + Y  +D LLCHDD LE RR AF+ YLV  +W++ +GG LD+   D++G+P  +  S +P+ NS VFF+V+  S+HQV EV     S  K R+S++GWF G S++        PP R   +  ++ +++EWI+  YLS +   +I+E F E SE+ L DF   DK+  +   L+  S+     GP N      A  D   FP ++     +L SEA  + LS+ TGL  H  +  N+E+DE         GEGPS       +  SSE  +V   S  ELRHW+   Y+++ D D    E  LDL    G     D + + GGF SY A+ EDEE+ +V
Sbjct:   38 DSVKEAWEGNQGGQFGSVALDSVPFPHGVIHPFIHNSD-FLEELKEELLNLNFQPKSNDLYQFKQSEDLKNRKESH-IKALRHVLFEDFRQWLSNITNVEL-EKTVDISCAQYGYTDTLLCHDDELEGRRFAFILYLV-PEWSKSDGGSLDLYGMDDNGQPGPIVKSLVPRWNSLVFFEVSPVSFHQVSEVL----SDGKCRLSVSGWFHGCSLERPPRGLDHPPVRSPHIPHDDQILYEWINPSYLSLESQAQIQEEFEERSEILLKDFLKADKFQAICAALETQSITLEKCGPPNKRCYDRAHGD---FPGVIGSCMELLRSEAFFLFLSNFTGLKLHFLASNNEESDE---------GEGPSEPNTVSQQGASSEDDKVPSCSG-ELRHWQHSYYTMIHDLDPERHEFALDLLLFCGC---DDWEAEYGGFTSYIAKEEDEELLTV 462

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Match: A0A0K2V3K4 (2oxoglutarate and irondependent oxygenase domain containing 1 [Otolemur garnettii] OS=Lepeophtheirus salmonis OX=72036 GN=OGFOD1 PE=4 SV=1)

HSP 1 Score: 263.077 bits (671), Expect = 9.435e-78
Identity = 165/433 (38.11%), Postives = 251/433 (57.97%), Query Frame = 3

Query:  144 LYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDE-SGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCL--DSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLD--CGGFYSYFAEGEDEEVSSV 1427
            L++ +PF    + N +   +   + ++ E+ ++   +K+NDLYKF QS D   +K+S  +  +++     +L WMK+ TGI+L +  ID+  + YK SDYLLCHDD LE RRIAF+WYLV  DWNE++GG LD+   DE SGEP RV NS +P +NSF FF+V+  S+HQV E+     S +K R++I GWFRG S++    A  P  ERLSP+ ++E   + WI+  +LS     +I+E+F + SE+ L +F   +K+NE+   L    L ++  GP N  +++  ++ +S  P I++     L S+A  + LS++TG+  H   + ++E DE E +         S SK+ K              S ELR WK G Y+L+RDGD+R +   + L ++VG      S  D   GGF SY A+ EDEE+ S+
Sbjct:   66 LFVNDPFPCCQLQNAVFEHSNNIDNLIEEVHALDYKEKNNDLYKFIQSMDLNGIKESIYIDALKNLLYGPLLSWMKDITGIELSEAHIDMFAAQYKFSDYLLCHDDELEGRRIAFIWYLVPSDWNEKDGGALDLYDRDENSGEPRRVINSLIPLRNSFSFFEVSHLSFHQVAEIL----SKDKTRLAITGWFRGKSLQGPPKAPCPLLERLSPLEMDENEFYNWINPSFLSPVTQGDIQETFEDKSEISLSNFLLPEKFNEVKNALLKSELSWKSIGPPN-RRSYDILSTESA-PEILKSFLMFLRSDAFFLFLSNVTGIKLHPLYEGDEEDDEQEED---------SKSKEEKC--------CSPTCSYELRRWKAGSYTLIRDGDKREQCLDVRLCFNVG---SLSSHWDDEVGGFTSYIAKDEDEELISI 472

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Match: L7M768 (Putative component of nua3 histone acetyltransferase complex OS=Rhipicephalus pulchellus OX=72859 PE=2 SV=1)

HSP 1 Score: 256.144 bits (653), Expect = 4.798e-75
Identity = 167/463 (36.07%), Postives = 248/463 (53.56%), Query Frame = 3

Query:   54 LSLNKKFLSNKF-DDYKSAIQKNEEYNLNDNLYMI-EPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSVD 1430
            L +N +  S+K  D+ ++A  + +  +      +I +PF+V  ++N +    G  + + NEL  I+   K+NDLYKF QS D +    +  +   R     ++ PW+++ TGI L D  I +T S Y  +D LLCHDD LE RRIAF+ YL    W  E+GG LD+  TD +G+P  +  S LP+ NSF FF+V+  S+HQV EV     S +K R+S+ GWF GP I   +    P  ERLS  HIEE L+  WIS  YL D V +++RE F   SE+ L +F  EDK   L + L   ++ ++  GP N   T       +    IV+E  R+  SEA+ ++LS++TGL  H S     E+D S      S+ EG S++ +R     +   QV       +R W  G Y+L  D D+   E  LD+   +   E    K +CGGF +Y  +GE+EE+ +++
Sbjct:   30 LKVNSELTSDKTKDELRAAFAEKKAGHFGTAAELITDPFNVCVLHNLLE-DEGSVDSLKNELFDIEFHAKNNDLYKFHQSDDLQNFD-TPYIHAFRKCLEGTLAPWLRDVTGIPL-DGTISLTCSKYSYTDVLLCHDDELEGRRIAFILYLT-PGWTTEDGGLLDLFDTDSNGQPRDIVRSILPRFNSFAFFEVSPVSFHQVAEVL----SEDKVRLSVGGWFHGPPISRPEPYIEPLLERLSWCHIEEELLRAWISPTYLLDSVAEKVREQFKNESEIHLQEFLQEDKCKALEEALSDPNVFWKQQGPRNRRWTLEC---PTPMAPIVEECLRVFRSEAMFLILSNLTGLKLH-SLLSVTESDSS------SEDEGGSNNSERPDHEPASCTQV-------VRKWSHGTYTLAHDHDRSSDECGLDVVLYLNCRE---WKPECGGFTTYIVKGEEEELLTLN 464

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Match: A0A094ZM79 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 OS=Schistosoma haematobium OX=6185 GN=MS3_03980 PE=4 SV=1)

HSP 1 Score: 258.455 bits (659), Expect = 2.238e-74
Identity = 156/484 (32.23%), Postives = 252/484 (52.07%), Query Frame = 3

Query:   60 LNKKFLSNKFDDYKSAIQK------NEEYNLNDNLYMIEPFSVGYINNFISM----------------------PNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLL---------KKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEE-NGGHLDIIST--------DESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYR--MH-GPMNVMQTFLAVN-DKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGK--------LSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSV 1337
            +N  F+S  F   K+A +        +E+  N++L    PF+    NNF+                             + +  E++ +  + + NDL+ F QS D   L          K   L   R+F L  +LPW+K+ TGI LY+N++D+T S+YK  DYLLCHDD L+ RR+AF+WYLV D W+ + +GG L +  +        DE+  P+++  +  PK+N F+FF+V+  S+HQV EV  +++     R+S++GWF GPS+   D   +P  E++SP+HIEE L+++WI+ +Y   + + +IR  F  +SE+QL +F   DK+ EL++CL  +     +H GP N        N D +  P + +++ R+  SEA++V+LSD+TG+  H  S  N   + + V   +   E  S SK+ +TE + + I            L+   LR  +PG Y+LL D D   +  RL+    +
Sbjct:   22 INSDFVSESF---KTAFRDCYCEKYAQEFVTNESLLRHIPFTFAKFNNFVQFRQEVAGILVFCFLKFELIETMDTKQLIQLVEEEVEQLPFARRGNDLFAFSQSCDVINLCPNENSSNTSKFPLLVSFRTFLLNCVLPWLKDITGIPLYENKVDLTSSLYKHGDYLLCHDDKLDGRRVAFIWYLVPDSWDSQIDGGELQLFESQPITDDGNDENFFPTKISTTIPPKRNMFMFFEVSPRSFHQVAEVFGHSK-----RLSLHGWFHGPSLWTVDNNIMPSVEKISPIHIEEELVYQWINPVYFDTEQLSKIRRKFCRSSEIQLTNFIKTDKWIELIQCLKGISTHNWLHCGPPNRRNYHCLFNTDLNAIPDLCEQIIRLFKSEAMLVILSDITGIQLHPCSIINGIHNTAVVNDNNITDEDVSQSKRMRTEDTVDAISTSDTDPNCLPYLTEPCLRKLQPGSYTLLSDADMTDQSWRLECLLHI 497

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Match: A0A430QKA4 (P4Hc domain-containing protein OS=Schistosoma bovis OX=6184 GN=DC041_0012532 PE=4 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 1.009e-73
Identity = 151/446 (33.86%), Postives = 244/446 (54.71%), Query Frame = 3

Query:  228 ELKSIKLSDKSNDLYKFQQSKDFKLL---------KKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEE-NGGHLDIIST--------DESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYR--MH-GPMNVMQTFLAVN-DKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTE-----LSSEVIQVGKLSSIE---LRHWKPGCYSLLRDGDQRYREARLDLF-----YSVGFPEKTDSKLDC-----------GGFYSYFAEGEDEEVSSV 1427
            E++ +    + NDL+ F QS D   L          K   L   R+F L  +LPW+K+ TGI LY+N++D+T S+YK  DYLLCHDD L+ RR+AF+WYLV D W+ + +GG L +  +        DE+  P+++  +  PK+N F+FF+V+  S+HQV EV  +++     R+S++GWF GPS+   D   +P  E++SP+HIEE L+++WI+ +Y   + + +IR  F  +SE+QL +F   DK+ EL++CL  +     +H GP N        N D +  P + +++ R+  SEA++V+LSD+TG+  H  S  N   + + V   +   +  S SK+ +TE     +S+ V  +  L  +    LR  +PG Y+LL D D   +  RL+       Y + +    ++K              G    Y A+GE++E+ +V
Sbjct:   13 EVEKLPFVRRGNDLFAFSQSCDVINLCPKENSSNTSKFPLLVSFRTFLLNCVLPWLKDITGIPLYENKVDLTSSLYKHGDYLLCHDDKLDGRRVAFIWYLVPDSWDSQIDGGELQLFESQTITDDGNDENFFPTKISTTIPPKRNMFMFFEVSPRSFHQVAEVFGHSK-----RLSLHGWFHGPSLWTVDNNIMPSVEKISPIHIEEELVYQWINPVYFDTEQLRKIRRKFCRSSEIQLTNFIKTDKWIELVQCLKGISTHNWLHCGPPNRRNYHCLFNTDLNTIPDLCEQIIRLFKSEAMLVILSDITGIQLHPCSIINGIDNTTVVNDNNITDQDVSQSKRMRTEDTVDAISTSVTDLNCLPYLTEPCLRKLQPGSYTLLSDADMTDQSWRLECLLHIHGYGLKYHSNNNNKTQLHDTNSQSNSSWGVQTVYVADGEEDELLTV 453

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Match: G3MPY1 (Fe2OG dioxygenase domain-containing protein OS=Amblyomma maculatum OX=34609 PE=2 SV=1)

HSP 1 Score: 252.677 bits (644), Expect = 1.131e-73
Identity = 164/470 (34.89%), Postives = 245/470 (52.13%), Query Frame = 3

Query:   30 RKNSPMDSLSLNKKFLSNKF-DDYKSAIQKNEEYNLNDNLYMI-EPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLD--SLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            RK+S +  L LN K  S++   + K+A  K E       + +I EPF+V  ++N ++   G  + + NEL  I+   K+NDLYKF QS D +    +  +   R     ++ PW+++ TGI L D  I +T S Y  +D LLCHDD LE RRIAF+ YL    W   +GG LD+   D +G+P  +  + +P+ NSF FF+V+  S+HQV EV     S +K RIS+ GWF GP+I        P  ERL P H+EE +   WI+ IYL+D +  EIR+ F ++SE+QL DF   +K  +L   L   ++ +   GP N   T   + +    P +V+E  R+  SEA+ ++LS++TGL  H  S  +  + E                K    E+   V       +  +R W  G Y+L  D D+   E RLD   +V +    D KL+ GG   Y  +GE+EE+ ++
Sbjct:   24 RKDSVV--LQLNHKLFSDETKSNLKAAFAKREAGQFGTAVELITEPFNVCILHNLLA-DAGCVDSLKNELFDIEFHAKNNDLYKFHQSDDLQNFD-TPYIHAFRKCLEGTLAPWLRDVTGIPL-DGTISLTCSKYSYTDVLLCHDDELEGRRIAFILYLT-PGWTSTDGGSLDLFDVDSNGQPRDIVRNIVPRFNSFAFFEVSPVSFHQVAEVL----SEDKLRISVGGWFHGPTIARPAPYIEPAGERLKPCHVEEDVFRSWINPIYLTDAIAKEIRQQFRDDSEIQLQDFLQANKCRDLEDALSDPNVLWSQRGPPNRRWT---LENPIPLPPVVEECLRVFRSEAMFLILSNLTGLKLHSLSTASDSSSED------------DEEKSSAAEVEKTVAGSAACCTQAVRKWSHGTYTLAHDHDRSAEERRLD---AVLYFNCKDWKLEYGGSTVYIVKGEEEEMLTL 465

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Cavefish
Match: ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-3294])

HSP 1 Score: 95.1301 bits (235), Expect = 3.154e-21
Identity = 70/228 (30.70%), Postives = 108/228 (47.37%), Query Frame = 3

Query:  687 KARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADES-----EVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKT 1355
            K R+S++GWF GPS+        P P    P +IEE ++ EW++E Y+      ++++ F +NSE++L +F        L      +   +   +  +    +          V+E   +  SE   +LLS++TGL  H  + ++ ++D S     E EG D  G+GPS+S  +K      V  VG     ELR W  G Y+LL D  Q  RE  LDL   +G   KT
Sbjct:   42 KCRLSLSGWFHGPSL--------PRP----PRYIEEEVLFEWVNETYMDPLFQAQVQQEFEDNSEIRLPNFLQIFTLRSLRSARSCVCVCVCVCVMCVCRCYSRLQVGSMEVCVRECWDLFSSEPFFLLLSNLTGLALHHLAPQDPQSDGSDRETAEEEGDDPAGQGPSTSSPQKKNKGPPVC-VG-----ELRRWSHGDYTLLHDSVQ--REFALDLLLHLGCKGKT 249

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Sea Lamprey
Match: ogfod1 (2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Source:ZFIN;Acc:ZDB-GENE-030131-3294])

HSP 1 Score: 226.483 bits (576), Expect = 5.484e-68
Identity = 161/502 (32.07%), Postives = 248/502 (49.40%), Query Frame = 3

Query:   30 RKNSPMDSLSLNKKFLSNKFDDYKSAIQKN-----EEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSI-KFKDVASIPPPERLSPVH-IEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCL--DSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH--GSSQKNKEADESEVE-------------------------GTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            R+ +  +  SL+++ LS+      SA  ++     EE  L        PF    I NF+    GF  ++  EL ++    KSNDLYKFQQS D K  ++   +  +R+   Q    W+ E   ++L D  +D+  + Y  +D LLCHDD LE RR+A++ YLV D W+EE+GG L +   DE+  P  V  S +P  N+ VFF+V+  SYHQV EV     S  K R+S+ GWF GP + + K    IP    L+P H  +E ++ EW++ +YL+ +    I++ F   SE+QL  F  E+K+  L   +   ++E+   GP +  +++ A  ++   P+ V E  ++L SE + +LL++ TGL  H         E+D+SE +                         G + +  G      R    +  V +       ELR W+ G Y+L+ D D R+    LDL    G    +D   D GGF SY A+ EDEE+ +V
Sbjct:   15 REEARSEMASLSERILSSAVRSRASAAWRDGAPLAEEMGLE---VCPGPFPHTVIPNFLQDEGGFLGRLQRELLALDFHHKSNDLYKFQQSDDLKE-RQEPCISALRTVLYQDFRAWLSEVLAVELEDT-VDMFCAKYDYTDVLLCHDDELEGRRVAYILYLVPD-WSEEDGGALQLFGVDENINPLSVVKSLVPAWNTLVFFEVSPMSYHQVSEVL----SQSKRRLSVGGWFHGPGLPRLKRSLHIPLA--LTPHHPCDEEVLLEWVNPLYLTKETQISIQDQFQRESEIQLKGFLREEKFQALCDAVRESTIEWERRGPPH-YRSYDAAAERL-LPSPVCECLKLLRSEVLFMLLANFTGLKLHFLALGASGSESDDSEFQEDGESGGEGEMKDDEDVAIEFNNNVGINREKLGVPGENLRTYRGNDAVPRCYG----ELRRWRHGSYTLIHDRDARHARYALDLLLYCGC---SDWDSDWGGFTSYVAKDEDEELLAV 495

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Yeast
Match: TPA1 (Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate [Source:SGD;Acc:S000000851])

HSP 1 Score: 66.2402 bits (160), Expect = 5.530e-12
Identity = 56/209 (26.79%), Postives = 97/209 (46.41%), Query Frame = 3

Query:  156 EPFSVGYINNFISMPNGFYEKILNELKS-IKLSDKSNDLYKFQQSKDF------------KLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDD--WNEENGGHLDIISTDESGEP-SRVHNSFLPKQNSFVFFKVADN-SYHQVREVKLNTESTEKARISINGWFRGPSI 731
            +P++ G I+  ++  +     +  E+++ I  + K  D+Y+  QS D             +L    K  Q + S   +    ++ +A    L  ++ D++ + Y    +LL HDD + +RRI+F+ YL + D  W    GG L +  +     P S      +P+ N   FFKV    S+H V EVK++     K R+SI GW+  P +
Sbjct:   51 QPYNWGTIHELVN--DDLLRAVRKEIETEIHFTKKETDIYRVNQSGDLANLSGLDWDDLSRLPNLFKLRQILYSKQYRDFFGYVTKAG--KLSGSKTDMSINTYTKGCHLLTHDDVIGSRRISFILYLPDPDRKWKSHYGGGLRLFPSILPNVPHSDPSAKLVPQFNQIAFFKVLPGFSFHDVEEVKVD-----KHRLSIQGWYHIPQV 250

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Nematostella
Match: EDO45080 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTS5])

HSP 1 Score: 226.098 bits (575), Expect = 1.572e-67
Identity = 148/446 (33.18%), Postives = 220/446 (49.33%), Query Frame = 3

Query:   96 YKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS--LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            + +A + N+ +  ND +   +PF    + NFI   +   E +  EL  +  + KS DLYKFQQS D K    S  +  +R    Q    W++E   + L D ++D++ + Y+ +D LLCHDD LE R +AF+ YLV   W E +GG LD+   DE G+P ++    +P+ NS  FF+V+  S+HQV EV     S +K R+SI+GWF G   +       P    +SP+ +E+  + +W++ IYL   VV EIR  F + SEV+L DF  +DKY E+L+ L S    +   GP N              P ++ E+ ++L S  +  LL   TGL+   +   + E   ++    D  G G SS    +                E R W  G Y+L+ D D    E  LD+    G  +    K   GG+ SY   GEDEE+ SV
Sbjct:   46 FSNAFRGNKYFKENDAIIHDKPFKCCVLPNFIENESYLLE-LKEELMKLDFNQKSVDLYKFQQSNDLKT-SPSYNITLLRDLIYQDFRKWLQETCDMKLTD-QVDLSCAKYEYTDVLLCHDDELEGRVVAFILYLVPPGWQECDGGSLDLFDVDEHGQPDKIVKKLVPEWNSLSFFEVSPISFHQVAEVL----SQDKTRLSISGWFHGSPPERPMPYKEPCNPTISPMPLEDEHLVKWVNPIYLDQGVVTEIRGRFEDESEVELQDFLLDDKYTEVLEALRSEKTTWSHRGPANKR----CYETADSLPEVLCELQKLLKSLPMFKLLRTFTGLDLADTPLTSNEGSPTQA-AQDGTGAGTSSPGNPRCH-------------GEARRWSHGSYTLVHDTDPERAEFALDIMLYCGCEDWDSDKF--GGYTSYLVSGEDEELLSV 464

[Close]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Medaka
Match: ogfod1 (2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:NCBI gene;Acc:101165714])

HSP 1 Score: 225.328 bits (573), Expect = 3.454e-66
Identity = 150/432 (34.72%), Postives = 226/432 (52.31%), Query Frame = 3

Query:  153 IEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLE--YRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFH----GSSQKNKEADES-EVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
              PF    I NF+S    F E +  EL  +   +KSNDLYKF+QS D K  +K   +  +R+        W+ +  G++L +  +D++ + Y+ +D LLCHDD LE RR+AF+ Y V   W   +GG LD+ +TD   +P  +  S +P  N+ V F+V+  S+HQVREV     S +K R+S++GWF G S++       PP  R   +  +E ++ EW++ +YL     ++I+E F ++SE+QL DF  E+K+ E+ + L   +  +   GP N  +    V      P  V E   +L SEA  +LLS+ TGL  H      S+  +EA +  E E   S  E  ++S K++ ELS+ V          +R W  G Y+LL DG+    E  LDL    G    T  + + GGF  Y A  EDEE+ +V
Sbjct:  111 CHPFPHCIIKNFLSS-KTFGENLQRELLELNFHEKSNDLYKFKQSDDLKK-RKEPHIAGLRAALFGPFRSWLGDVLGVEL-ETTVDVSCARYEYTDVLLCHDDELEGRRVAFILYFV-PPWESSDGGTLDLYATDSHFQPQSIAKSLVPSWNTLVLFEVSPVSFHQVREVL----SQDKCRLSVSGWFHGSSLQRPPRYKEPPFPRNPHLPRDETVLLEWVNPVYLDISYQEKIQEEFEDSSEIQLKDFLREEKFKEVGEALQQAQIVWMKRGPPN--KRCFDVASLDTLPECVTECWELLNSEAFFLLLSNFTGLRLHYLCPADSEDEEEAKQKMEGEAAGSSTESSAASAKKEKELSTPVC------CGNVRRWSHGSYTLLHDGEAEKAEYALDLLLPFGC---TGWQSEFGGFTCYIANEEDEELLTV 523

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BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Planmine SMEST
Match: SMESG000053951.1 (SMESG000053951.1)

HSP 1 Score: 935.25 bits (2416), Expect = 0.000e+0
Identity = 454/461 (98.48%), Postives = 458/461 (99.35%), Query Frame = 3

Query:   45 MDSLSLNKKFLSNKFDDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEEVSSV 1427
            MDSLSLN KFLSN+FDDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVE TDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEE+ ++
Sbjct:    1 MDSLSLNTKFLSNEFDDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFISMPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFFLQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVWYLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSYHQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEEALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDSLEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGLNFHGSSQKNKEADESEVERTDSKGEGPSSSKKRKTELSSEVIQVGKLSSIELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYFAEGEDEELLTI 461

HSP 2 Score: 102.834 bits (255), Expect = 4.339e-23
Identity = 47/47 (100.00%), Postives = 47/47 (100.00%), Query Frame = 1

Query: 1465 LLTIAPCRNALSLVYADDQTMGFMKYITSKFHHSDNLYDFHSTFYEY 1605
            LLTIAPCRNALSLVYADDQTMGFMKYITSKFHHSDNLYDFHSTFYEY
Sbjct:  458 LLTIAPCRNALSLVYADDQTMGFMKYITSKFHHSDNLYDFHSTFYEY 504

The following BLAST results are available for this feature:

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Celegans
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Fly
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Zebrafish
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Xenopus
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Mouse
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Cavefish
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Sea Lamprey
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Yeast
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Nematostella
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Medaka
BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Planmine SMEST

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
OGFOD1	1.046e-70	35.18	2-oxoglutarate and iron dependent oxygenase domain...	[more]
OGFOD1	1.141e-53	31.19	2-oxoglutarate and iron dependent oxygenase domain...	[more]
OGFOD1	2.278e-32	40.33	2-oxoglutarate and iron dependent oxygenase domain...	[more]
OGFOD1	6.721e-16	39.29	2-oxoglutarate and iron dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
C17G10.1	6.309e-37	27.61	pep chromosome:WBcel235:II:5596560:5598449:1 gene:...	[more]
C17G10.1	6.309e-37	27.61	pep chromosome:WBcel235:II:5596547:5598449:1 gene:...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
sud1	1.650e-39	27.05	gene:FBgn0265189 transcript:FBtr0339113	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ogfod1	3.723e-74	36.06	2-oxoglutarate and iron-dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ogfod1	3.751e-67	36.02	2-oxoglutarate and iron dependent oxygenase domain...	[more]
ogfod1	7.056e-67	36.18	2-oxoglutarate and iron dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Ogfod1	4.172e-68	34.73	2-oxoglutarate and iron-dependent oxygenase domain...	[more]
Ogfod1	5.499e-68	34.73	2-oxoglutarate and iron-dependent oxygenase domain...	[more]
Ogfod1	9.975e-52	30.99	2-oxoglutarate and iron-dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8N543\|OGFD1_HUMAN	5.023e-70	35.18	Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=960...	[more]
sp\|Q5R4R3\|OGFD1_PONAB	5.090e-68	34.73	Prolyl 3-hydroxylase OGFOD1 OS=Pongo abelii OX=960...	[more]
sp\|Q3MI03\|OGFD1_BOVIN	1.346e-67	34.21	Prolyl 3-hydroxylase OGFOD1 OS=Bos taurus OX=9913 ...	[more]
sp\|Q3U0K8\|OGFD1_MOUSE	3.846e-67	34.73	Prolyl 3-hydroxylase OGFOD1 OS=Mus musculus OX=100...	[more]
sp\|Q6DE73\|OGFD1_XENLA	6.535e-67	35.41	Prolyl 3-hydroxylase OGFOD1 OS=Xenopus laevis OX=8...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0K2V3K4	9.435e-78	38.11	2oxoglutarate and irondependent oxygenase domain c...	[more]
L7M768	4.798e-75	36.07	Putative component of nua3 histone acetyltransfera...	[more]
A0A094ZM79	2.238e-74	32.23	2-oxoglutarate and iron-dependent oxygenase domain...	[more]
A0A430QKA4	1.009e-73	33.86	P4Hc domain-containing protein OS=Schistosoma bovi...	[more]
G3MPY1	1.131e-73	34.89	Fe2OG dioxygenase domain-containing protein OS=Amb...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ogfod1	3.154e-21	30.70	2-oxoglutarate and iron-dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ogfod1	5.484e-68	32.07	2-oxoglutarate and iron-dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
TPA1	5.530e-12	26.79	Fe(II)/2-oxoglutarate-dependent dioxygenase family...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO45080	1.572e-67	33.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ogfod1	3.454e-66	34.72	2-oxoglutarate and iron dependent oxygenase domain...	[more]

BLAST of 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000053951.1	4.339e-23	98.48	SMESG000053951.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30023139 ID=SMED30023139|Name=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1606bp
TTTAATTTGTTTTATATTTTTGTACTTAGAGAAAGAATAGCCCAATGGAC
TCTTTGAGTTTAAACAAAAAATTTCTAAGTAATAAATTTGATGATTACAA
ATCTGCCATACAAAAAAATGAAGAATATAATCTTAACGATAATTTATATA
TGATTGAACCATTTTCTGTCGGTTATATTAATAATTTTATATCTATGCCC
AATGGTTTTTACGAAAAAATTCTTAATGAATTGAAATCAATTAAATTATC
CGATAAAAGCAATGATTTGTATAAGTTTCAACAAAGCAAAGATTTTAAAT
TGCTTAAGAAATCCAAAACCTTACAACATATACGATCATTCTTTTTACAA
TCTATTCTTCCTTGGATGAAAGAAGCTACTGGCATTGATTTGTATGACAA
TGAAATTGATATTACTTACTCAGTATATAAAGATTCAGATTATTTACTTT
GTCATGATGACCATTTAGAAGCACGCCGAATCGCTTTTGTTTGGTATCTT
GTAAACGATGATTGGAATGAGGAAAACGGTGGGCATTTGGATATAATTTC
CACTGATGAATCTGGCGAACCATCTCGTGTTCATAATTCATTTTTACCAA
AACAAAATTCATTTGTTTTTTTTAAAGTTGCCGATAATTCATATCACCAG
GTAAGAGAAGTAAAGCTAAATACCGAATCCACGGAGAAAGCAAGAATATC
TATTAATGGCTGGTTTCGAGGTCCATCCATCAAATTTAAAGATGTAGCCT
CAATACCACCTCCCGAACGGTTATCTCCTGTCCATATTGAAGAAGCACTA
ATTCATGAATGGATTTCTGAAATCTATCTCAGTGATCAAGTTGTTGATGA
AATTAGGGAATCGTTTCTTGAGAATTCAGAAGTTCAACTTGTTGACTTTT
TCAATGAAGATAAATATAATGAACTGTTGAAATGTCTCGATAGTTTAGAG
TATCGAATGCATGGTCCAATGAATGTGATGCAGACATTTCTTGCTGTCAA
TGATAAGTCAGAATTCCCGGCTATTGTTCAAGAAGTCTGTCGAATTTTAG
GATCAGAAGCAATAATGGTTTTATTGAGTGACATGACGGGGCTCAACTTC
CATGGAAGCTCTCAGAAAAATAAGGAAGCAGACGAAAGTGAGGTAGAAGG
GACCGATTCAAAGGGTGAAGGACCTTCAAGTAGTAAGAAAAGAAAAACCG
AGTTGAGTTCCGAAGTGATTCAGGTGGGAAAGCTGTCAAGCATTGAATTA
CGGCATTGGAAACCTGGATGTTACAGTCTGCTGAGGGACGGAGATCAACG
GTATAGAGAAGCAAGACTAGATTTATTTTATTCAGTCGGGTTTCCAGAAA
AAACCGATAGCAAACTGGACTGCGGTGGATTTTATTCTTATTTTGCCGAA
GGAGAAGATGAGGAGGTTTCTTCTGTTGATTTGGTAATGTTTACCGCTGT
CATTTGATGTTTAGCTATTGACAATCGCTCCTTGTCGAAATGCCTTGTCC
TTGGTTTACGCAGATGATCAAACAATGGGATTCATGAAGTATATCACAAG
CAAGTTTCACCACTCTGATAACTTGTATGATTTCCACTCTACGTTTTATG
AATACG

protein sequence of SMED30023139-orf-1

>SMED30023139-orf-1 ID=SMED30023139-orf-1|Name=SMED30023139-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=471bp
MDSLSLNKKFLSNKFDDYKSAIQKNEEYNLNDNLYMIEPFSVGYINNFIS
MPNGFYEKILNELKSIKLSDKSNDLYKFQQSKDFKLLKKSKTLQHIRSFF
LQSILPWMKEATGIDLYDNEIDITYSVYKDSDYLLCHDDHLEARRIAFVW
YLVNDDWNEENGGHLDIISTDESGEPSRVHNSFLPKQNSFVFFKVADNSY
HQVREVKLNTESTEKARISINGWFRGPSIKFKDVASIPPPERLSPVHIEE
ALIHEWISEIYLSDQVVDEIRESFLENSEVQLVDFFNEDKYNELLKCLDS
LEYRMHGPMNVMQTFLAVNDKSEFPAIVQEVCRILGSEAIMVLLSDMTGL
NFHGSSQKNKEADESEVEGTDSKGEGPSSSKKRKTELSSEVIQVGKLSSI
ELRHWKPGCYSLLRDGDQRYREARLDLFYSVGFPEKTDSKLDCGGFYSYF
AEGEDEEVSSVDLVMFTAVI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000429	neoblast
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR039558	TPA1/OFD1_N
IPR019601	Oxoglutarate/Fe-dep_Oase_C
IPR006620	Pro_4_hyd_alph

Vocabulary: **molecular function**
Term	Definition
GO:0031418	L-ascorbic acid binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Vocabulary: **biological process**
Term	Definition
GO:0055114	oxidation-reduction process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006620	Prolyl 4-hydroxylase, alpha subunit	SMART	SM00702	p4hc	coord: 40..225 e-value: 1.1E-6 score: 38.3
None	No IPR available	GENE3D	G3DSA:2.60.120.620		coord: 236..467 e-value: 4.9E-36 score: 126.1
None	No IPR available	GENE3D	G3DSA:2.60.120.620		coord: 13..235 e-value: 1.2E-57 score: 197.2
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 354..387
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 357..387
None	No IPR available	PANTHER	PTHR12117	HISTONE ACETYLTRANSFERASE COMPLEX	coord: 24..461
IPR039558	Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain	PFAM	PF13661	2OG-FeII_Oxy_4	coord: 124..225 e-value: 4.1E-24 score: 85.1
IPR019601	Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain	PFAM	PF10637	Ofd1_CTDD	coord: 252..457 e-value: 7.8E-13 score: 48.4