Cathepsin L2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30023109 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 18Note: Hover over icons to view figure legend
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 298.901 bits (764), Expect = 9.287e-99 Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + + L + ++ + L QW + ++N+ Y E RR +WE N+K I HN ++ G ++FT+ +N F D+T EF+ + R + G + PL + P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS N GC+GGLM AF ++D GG++SE+ YPY+A + +C +N V + +G+ +I + E +L AVA GPISV I +F YK G+Y EPDCS +HGVLVVGYG S N+ YW+VKNSWG WGM GY+ M+KD+ N C IAS AS+P +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 298.901 bits (764), Expect = 9.287e-99 Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + + L + ++ + L QW + ++N+ Y E RR +WE N+K I HN ++ G ++FT+ +N F D+T EF+ + R + G + PL + P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS N GC+GGLM AF ++D GG++SE+ YPY+A + +C +N V + +G+ +I + E +L AVA GPISV I +F YK G+Y EPDCS +HGVLVVGYG S N+ YW+VKNSWG WGM GY+ M+KD+ N C IAS AS+P +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSK (cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536]) HSP 1 Score: 282.722 bits (722), Expect = 1.837e-92 Identity = 150/322 (46.58%), Postives = 201/322 (62.42%), Query Frame = 1
Query: 169 LLSFFAISIALNLE--LNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEF--KAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
+L +S AL E L+ W+L+ K + K Y N E+ RR+IWE NLKYI HNL+ LG++T+ L +N D+T E K L L +++ +T P P +VD+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ +KTG+L++ S Q LVDC N GC GG MT+AF ++ GI+SE YPY Q+ +C++N + GY+EI E NE +L AVA GP+SV I SL +FQ Y GVY + C S NH VL VGYG + +WI+KNSWG WG KGYI M+++K+N C IA+ ASFP
Sbjct: 6 VLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSS (cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545]) HSP 1 Score: 278.485 bits (711), Expect = 9.259e-91 Identity = 149/332 (44.88%), Postives = 199/332 (59.94%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGN-TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYG---CHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M+ L + S + + L+ W L+ K Y K Y+ E +RR+IWE NLK++ HNL+H +G++++ LG+N D+T E ++ S + N TY N +P +VDW EKG VT+VK QG CG+CWAFS G+LE Q KTG+LVS S Q LVDCS YG C+GG MT+AF I D GI+S+ YPYKA C ++ + S Y E+ E L AVAN+GP+SVG+ +F LY+SGVY EP C++ NHGVLVVGYG YW+VKNSWG +G +GYI M+++K N C IASF S+P I
Sbjct: 1 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRI-LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 331
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538]) HSP 1 Score: 271.937 bits (694), Expect = 3.296e-88 Identity = 145/332 (43.67%), Postives = 201/332 (60.54%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + + L + + L+ +W + + + Y E RR +WE N+K I HN ++ G + FT+ +N F D+T+ EF+ + + + G + PL ++P +VDW +KGYVT VK+Q +CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS N GC+GG M AF +K+ GG++SE+ YPY A C + V + +G+ + E +L AVA GPISV + +FQ YKSG+Y EPDC S+ +HGVLVVGYG S N YW+VKNSWGP WG GY+ ++KDK+N C IA+ AS+P +
Sbjct: 5 LVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLY-GANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPL-FLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 266.544 bits (680), Expect = 1.936e-86 Identity = 142/311 (45.66%), Postives = 197/311 (63.34%), Query Frame = 1
Query: 217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAI----YLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++W Y + ++K Y E + N+ +I HN DH LG TF +G+N ADL ++++ + L G+ R K +++L P N VP VDW + VTDVK+QG CGSCWAFS TG+LEGQ RK G+LVS SEQ LVDCS N+GC+GGLM AF I+D G+++E+ YPYK + + C FN+ V GY + E +E L IAVA +GPIS+ I +FQLYK GVY + +CS +HGVL+VGYGT + +YWIVKNSWG WG KGYI ++++++N C +A+ AS+P++
Sbjct: 30 EKWDDYKEDFDKEYSES-EEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDSRI-KNSSSFLAPFNV-QVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 205.297 bits (521), Expect = 1.729e-64 Identity = 103/197 (52.28%), Postives = 137/197 (69.54%), Query Frame = 1
Query: 547 CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
CGSCWAFS TG+LEGQ RK G+LVS SEQ LVDCS N+GC+GGLM AF I+D G+++E+ YPYK + + C FN+ V GY + E +E L IAVA +GPIS+ I +FQLYK GVY + +CS +HGVL+VGYGT + +YWIVKNSWG WG KGYI ++++++N C +A+ AS+P++
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 205.297 bits (521), Expect = 1.729e-64 Identity = 103/197 (52.28%), Postives = 137/197 (69.54%), Query Frame = 1
Query: 547 CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
CGSCWAFS TG+LEGQ RK G+LVS SEQ LVDCS N+GC+GGLM AF I+D G+++E+ YPYK + + C FN+ V GY + E +E L IAVA +GPIS+ I +FQLYK GVY + +CS +HGVL+VGYGT + +YWIVKNSWG WG KGYI ++++++N C +A+ AS+P++
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196) HSP 1 Score: 199.519 bits (506), Expect = 5.035e-59 Identity = 114/306 (37.25%), Postives = 169/306 (55.23%), Query Frame = 1
Query: 232 YMKIYNKTYENPFHELIRRMIWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGN--TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++ + K Y N L R +++ N K I + + +Y FT +F+D+T EFK I L + P + N + +N ++P + DW EKG VT VK+QG CGSCWAFSTTG++EG +F +LVS SEQ+LVDC + GC+GGL ++A+ +I +GG+E E YPY + C R + ++G E+ +E + + +GPIS+G++ + Q Y+ GV + P NHGVL+VGYG YWIVKNSWGP WG GY + + K N C + A+ ++
Sbjct: 177 FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQKNEQGTAVYGFT----KFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSMDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN-TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196) HSP 1 Score: 199.519 bits (506), Expect = 5.035e-59 Identity = 114/306 (37.25%), Postives = 169/306 (55.23%), Query Frame = 1
Query: 232 YMKIYNKTYENPFHELIRRMIWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGN--TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++ + K Y N L R +++ N K I + + +Y FT +F+D+T EFK I L + P + N + +N ++P + DW EKG VT VK+QG CGSCWAFSTTG++EG +F +LVS SEQ+LVDC + GC+GGL ++A+ +I +GG+E E YPY + C R + ++G E+ +E + + +GPIS+G++ + Q Y+ GV + P NHGVL+VGYG YWIVKNSWGP WG GY + + K N C + A+ ++
Sbjct: 177 FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQKNEQGTAVYGFT----KFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSMDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN-TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592) HSP 1 Score: 274.633 bits (701), Expect = 1.706e-89 Identity = 148/316 (46.84%), Postives = 202/316 (63.92%), Query Frame = 1
Query: 217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++W + + K Y++ E R I+ +N I KHN G +F L +N++ADL H EF+ + L LR G T++ P + +P +VDW KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS N GC+GGLM +AF IKD GGI++E+ YPY+A +C FN+ V + G+ +I + +E +A AVA GP+SV I S +FQ Y GVYNEP C ++ +HGVLVVG+GT + ++YW+VKNSWG WG KG+I M ++K+NQC IAS +S+P++
Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593) HSP 1 Score: 275.018 bits (702), Expect = 2.775e-89 Identity = 148/316 (46.84%), Postives = 202/316 (63.92%), Query Frame = 1
Query: 217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++W + + K Y++ E R I+ +N I KHN G +F L +N++ADL H EF+ + L LR G T++ P + +P +VDW KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS N GC+GGLM +AF IKD GGI++E+ YPY+A +C FN+ V + G+ +I + +E +A AVA GP+SV I S +FQ Y GVYNEP C ++ +HGVLVVG+GT + ++YW+VKNSWG WG KG+I M ++K+NQC IAS +S+P++
Sbjct: 57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955) HSP 1 Score: 270.781 bits (691), Expect = 4.689e-88 Identity = 147/307 (47.88%), Postives = 198/307 (64.50%), Query Frame = 1
Query: 244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ K Y++ E R I+ +N I KHN G +F L +N++ADL H EF+ + L LR G T++ P + +P +VDW KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS N GC+GGLM +AF IKD GGI++E+ YPY+A +C FN+ V + G+ +I + +E +A AVA GP+SV I S +FQ Y GVYNEP C ++ +HGVLVVG+GT + ++YW+VKNSWG WG KG+I M ++K+NQC IAS +S+P++
Sbjct: 33 HRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021) HSP 1 Score: 238.424 bits (607), Expect = 1.116e-76 Identity = 124/230 (53.91%), Postives = 164/230 (71.30%), Query Frame = 1
Query: 448 GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
G T++ P + +P +VDW KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS N GC+GGLM +AF IKD GGI++E+ YPY+A +C FN+ V + G+ +I + +E +A AVA GP+SV I S +FQ Y GVYNEP C ++ +HGVLVVG+GT + ++YW+VKNSWG WG KG+I M ++K+NQC IAS +S+P++
Sbjct: 21 GVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG12163 (gene:FBgn0260462 transcript:FBtr0078822) HSP 1 Score: 210.69 bits (535), Expect = 3.219e-63 Identity = 121/305 (39.67%), Postives = 181/305 (59.34%), Query Frame = 1
Query: 244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFK---AIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYN--EPDCSRVP-NHGVLVVGYGTSVNDN------YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ + Y + +R I+ NLK I + N + ++G + GI +FAD+T +E+K ++ + G+ + P +P DW +K VT VK+QG CGSCWAFS TG++EG + KTG L FSEQ+L+DC ++ C+GGLM +A+ IKD+GG+E E EYPYKA++ C FNR+ V+G+ ++ + NE ++ + GPIS+GI+ + Q Y+ GV + + CS+ +HGVLVVGYG S N YWIVKNSWGP WG +GY + + DN C ++ A+ V+
Sbjct: 176 FGRRYVSTAERQMRLRIFRQNLKTIEELNAN-EMGSAKY--GITEFADMTSSEYKERTGLWQRDEAKAT-GGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMATSAVL 474
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61]) HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101 Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
WKL + K+Y + E R++ W N K + HN+ D GL ++ LG+ FAD+++ E++ + G L + G+T+ A VP VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S NYGC GGLM AF I+ G+++E YPY+AQ C FN S V S +GY +I +E +L AVA GPISV I +FQLY SGVYNEPDCS +HGVL VGYG+S D+YWIVKNSWG WG++GYI MS++K NQC IA+ AS+P++
Sbjct: 29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61]) HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101 Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
WKL + K+Y + E R++ W N K + HN+ D GL ++ LG+ FAD+++ E++ + G L + G+T+ A VP VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S NYGC GGLM AF I+ G+++E YPY+AQ C FN S V S +GY +I +E +L AVA GPISV I +FQLY SGVYNEPDCS +HGVL VGYG+S D+YWIVKNSWG WG++GYI MS++K NQC IA+ AS+P++
Sbjct: 29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61]) HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101 Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
WKL + K+Y + E R++ W N K + HN+ D GL ++ LG+ FAD+++ E++ + G L + G+T+ A VP VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S NYGC GGLM AF I+ G+++E YPY+AQ C FN S V S +GY +I +E +L AVA GPISV I +FQLY SGVYNEPDCS +HGVL VGYG+S D+YWIVKNSWG WG++GYI MS++K NQC IA+ AS+P++
Sbjct: 29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 296.975 bits (759), Expect = 3.314e-98 Identity = 158/337 (46.88%), Postives = 220/337 (65.28%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M L VT Y+ + FA + +++++L+D W + + K+Y E+ RRMIWE+NL+ I +HN ++ LG +TF +G+NQF D+T+ EF+ PN+T G ++ P F P VDW ++GYVT VKDQ +CGSCW+FS+TG+LEGQ FRKTG+L+S SEQ LVDCS N GC+GGLM AF +K+ G++SEQ YPY A+ L C ++ V ++G+ +I + NE +L AVA GP+SV I S + Q Y+SG+Y E C+ +H VLVVGYG D YWIVKNSW WG KGYI+M+KDK+N C IA+ AS+P++
Sbjct: 2 MFALLVTLYISAVFA-APSIDIQLDDHWNSWKSQHGKSYHEDV-EVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEP-KFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 296.975 bits (759), Expect = 3.314e-98 Identity = 158/337 (46.88%), Postives = 220/337 (65.28%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M L VT Y+ + FA + +++++L+D W + + K+Y E+ RRMIWE+NL+ I +HN ++ LG +TF +G+NQF D+T+ EF+ PN+T G ++ P F P VDW ++GYVT VKDQ +CGSCW+FS+TG+LEGQ FRKTG+L+S SEQ LVDCS N GC+GGLM AF +K+ G++SEQ YPY A+ L C ++ V ++G+ +I + NE +L AVA GP+SV I S + Q Y+SG+Y E C+ +H VLVVGYG D YWIVKNSW WG KGYI+M+KDK+N C IA+ AS+P++
Sbjct: 2 MFALLVTLYISAVFA-APSIDIQLDDHWNSWKSQHGKSYHEDV-EVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEP-KFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216]) HSP 1 Score: 298.901 bits (764), Expect = 6.491e-99 Identity = 152/330 (46.06%), Postives = 204/330 (61.82%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCS-RVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M ++ + LS I + L+ +W+L+ K Y++ Y E+ RR IWE NL I +HN + GL+T+ L +N D+T E + + PN + NTY+P N+ +P +D+ +KGYVT V +QG CGSCWAFS+ G+LEGQ +KTG+LVS S Q LVDC NYGC GG MT+AF ++D GGI+S+ EYPY Q C +N + + GYKEI +E +L AVAN GP+SV I SL +FQ YK GVY + C+ NH VLVVGYG +WI+KNSWG WG KGY+ +++DK N C IAS ASFPV+
Sbjct: 1 MWWFSLLSFALSLVKIGLCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWNS-RIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDTDNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 329
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216]) HSP 1 Score: 299.286 bits (765), Expect = 7.631e-99 Identity = 152/330 (46.06%), Postives = 204/330 (61.82%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCS-RVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M ++ + LS I + L+ +W+L+ K Y++ Y E+ RR IWE NL I +HN + GL+T+ L +N D+T E + + PN + NTY+P N+ +P +D+ +KGYVT V +QG CGSCWAFS+ G+LEGQ +KTG+LVS S Q LVDC NYGC GG MT+AF ++D GGI+S+ EYPY Q C +N + + GYKEI +E +L AVAN GP+SV I SL +FQ YK GVY + C+ NH VLVVGYG +WI+KNSWG WG KGY+ +++DK N C IAS ASFPV+
Sbjct: 8 MWWFSLLSFALSLVKIGLCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWNS-RIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDTDNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 336
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 287.345 bits (734), Expect = 2.885e-94 Identity = 152/333 (45.65%), Postives = 213/333 (63.96%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDN----YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + L+ + + L++ W L+ + K+Y P E RR++WE NL+ I HNL+H LG ++ +LG+NQF D+T+ EF+ + + G+T+L P N F P +VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ +R TG+++S SEQ LVDCS + N GC+GGLM AF +KD GGI+SE YPY A+ C ++ + + +G+ ++ +E L AVA+ GP+SV + +FQ YKSG+Y EP+CS +HGVLVVGYG D YWIVKNSW WG GYI+++KD+ N C IA+ AS+P++
Sbjct: 5 LGIAAICLTTVFAAPTTDPALDNHWNLWKNWHKKSYA-PKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 286.96 bits (733), Expect = 4.627e-94 Identity = 152/333 (45.65%), Postives = 213/333 (63.96%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + L+ + + L++ W L+ + K+Y P E RR++WE NL+ I HNL+H LG ++ +LG+NQF D+T+ EF+ + + G+T+L P N F P +VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ +R TG+++S SEQ LVDCS + N GC+GGLM AF +KD GGI+SE YPY A+ C ++ + + +G+ ++ +E L AVA+ GP+SV + +FQ YKSG+Y EP+CS +HGVLVVGYG D YWIVKNSW WG GYI+++KD+ N C IA+ AS+P++
Sbjct: 12 LGIAAICLTTVFAAPTTDPALDNHWNLWKNWHKKSYA-PKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433]) HSP 1 Score: 283.878 bits (725), Expect = 6.008e-93 Identity = 144/317 (45.43%), Postives = 198/317 (62.46%), Query Frame = 1
Query: 202 NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLN--------AFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
N L+ +W+++ Y+K Y+N HEL+RR+IWE NL I HNL+ GL+T+ LG+N+F D+T E + + L+ + T + P N + +P ++D+ +KGYVT ++DQG+CGSCWAFST G+LEGQ +KTG+LV S Q LVDC N+GC GG MT+AF +K GI+SE+ YPY C +N S + G+KE+ + +E +L AV GPISVGI L+ F LYK G+Y + C NH VL VGYG YWI+KNSWG WG KGYI M+++K N C IA+ AS+PV+
Sbjct: 21 NGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEE--VVRMMTGLKVH----TGMGPTNLTSDEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKDNFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsk (cathepsin K [Source:MGI Symbol;Acc:MGI:107823]) HSP 1 Score: 288.886 bits (738), Expect = 4.357e-95 Identity = 145/320 (45.31%), Postives = 200/320 (62.50%), Query Frame = 1
Query: 169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
LL + +++ L+ QW+L+ K + K Y + E+ RR+IWE NLK I HNL+ LG++T+ L +N D+T E + P+++ +T P VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ +KTG+L++ S Q LVDC NYGC GG MT+AF ++ GGI+SE YPY Q +C++N + GY+EI NE +L AVA GPISV I SL +FQ Y GVY + +C R NH VLVVGYGT +WI+KNSWG WG KGY ++++K+N C I + ASFP
Sbjct: 8 LLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452]) HSP 1 Score: 274.248 bits (700), Expect = 2.168e-89 Identity = 154/330 (46.67%), Postives = 199/330 (60.30%), Query Frame = 1
Query: 148 ILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTG-NTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSR-VPNHGVLVVGYG-TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ + L + + A N L+ W+ + + KTY N E +R +WE+N K I HN D+ G + F+L +N F DLT+ EF+ + + K + PL +VP +VDW + GYVT VKDQG CGSCWAFS GSLEGQ FRKTG+LV S Q LVDCS S N GC GGL AF +KD GG+++ YPY+A C +N +V+G+ + +E +L AVA GPISVGI +FQ YK G+Y EPDCS V +H VLVVGYG S YW+VKNSWG WGM GYI M+KD++N C IAS AS+PV+
Sbjct: 4 VFLLATLCLGVVSAAPAHNPSLDAVWEEWKTKHKKTY-NMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPLLG-DVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNVQSSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564]) HSP 1 Score: 274.248 bits (700), Expect = 2.714e-89 Identity = 142/308 (46.10%), Postives = 200/308 (64.94%), Query Frame = 1
Query: 220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+W + + + Y E RR IWE N++ I HN ++ G + F++ +N F D+T+ EF+ + + +K G + PL +P +VDW EKG VT VK+QG+CGSCWAFS +G LEGQ F KTG+L+S SEQ LVDCS + N GC+GGLM AF IK+ GG++SE+ YPY+A+ +C + V + +G+ +I + E +L AVA GPISV + S + Q Y SG+Y EP+C S+ +HGVL+VGY GT N N YW+VKNSWG WGM+GYI ++KD+DN C +A+ AS+PV+
Sbjct: 28 EWHQWKSTHRRLY-GTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564]) HSP 1 Score: 274.248 bits (700), Expect = 2.714e-89 Identity = 142/308 (46.10%), Postives = 200/308 (64.94%), Query Frame = 1
Query: 220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+W + + + Y E RR IWE N++ I HN ++ G + F++ +N F D+T+ EF+ + + +K G + PL +P +VDW EKG VT VK+QG+CGSCWAFS +G LEGQ F KTG+L+S SEQ LVDCS + N GC+GGLM AF IK+ GG++SE+ YPY+A+ +C + V + +G+ +I + E +L AVA GPISV + S + Q Y SG+Y EP+C S+ +HGVL+VGY GT N N YW+VKNSWG WGM+GYI ++KD+DN C +A+ AS+PV+
Sbjct: 28 EWHQWKSTHRRLY-GTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctss (cathepsin S [Source:MGI Symbol;Acc:MGI:107341]) HSP 1 Score: 274.248 bits (700), Expect = 2.910e-89 Identity = 149/334 (44.61%), Postives = 204/334 (61.08%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLR-PNKTGNTY-LPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS----ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+R L P + S + + L+ W L+ K + K Y++ E +RR+IWE NLK+I HNL++ +G++T+ +G+N D+T+ E + G LR P ++ T + +P VDW EKG VT+VK QG CG+CWAFS G+LEGQ KTG+L+S S Q LVDCS N GC GG MT AF I D GGIE++ YPYKA C +N + S Y ++ +E +L AVA +GP+SVGI S +F YKSGVY++P C+ NHGVLVVGYGT +YW+VKNSWG +G +GYI M+++ N C IAS+ S+P I
Sbjct: 9 IRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEI--LCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI 340
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2) HSP 1 Score: 298.901 bits (764), Expect = 4.460e-98 Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + + L + ++ + L QW + ++N+ Y E RR +WE N+K I HN ++ G ++FT+ +N F D+T EF+ + R + G + PL + P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS N GC+GGLM AF ++D GG++SE+ YPY+A + +C +N V + +G+ +I + E +L AVA GPISV I +F YK G+Y EPDCS +HGVLVVGYG S N+ YW+VKNSWG WGM GY+ M+KD+ N C IAS AS+P +
Sbjct: 5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1) HSP 1 Score: 297.36 bits (760), Expect = 1.769e-97 Identity = 154/324 (47.53%), Postives = 203/324 (62.65%), Query Frame = 1
Query: 172 LSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + ++ N L QW + ++N+ Y E RR +WE N+K I HN ++ G ++FT+ +N F D+T EF+ + R + G + PL + P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS N GC+GGLM AF + D GG++SE+ YPY+A + +C +N V + +G+ +I + E +L AVA GPISV I +F YK G+Y EPDCS +HGVLVVGYG S N YW+VKNSWG WGM GYI M+KD+ N C IAS AS+P +
Sbjct: 12 LGIASATLTFNHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GL24|CATL1_CANLF (Cathepsin L1 OS=Canis lupus familiaris OX=9615 GN=CTSL PE=2 SV=1) HSP 1 Score: 290.426 bits (742), Expect = 8.375e-95 Identity = 152/331 (45.92%), Postives = 209/331 (63.14%), Query Frame = 1
Query: 151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L +T L + + + LN QW + + + Y E RR +WE N+K I HN ++ G + FT+ +N F D+T+ EF+ + + +K G + PL A +P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS + N GC+GGLM +AF +KD GG++SE+ YPY + C + + +G+ ++ + E +L AVA GPISV I +FQ YKSG+Y +PDC S+ +HGVLVVGY GT N+ +WIVKNSWGP WG GY+ M+KD++N C IA+ AS+P +
Sbjct: 5 LFLTALCLGIASAAPKFDQSLNAQWYQWKATHRRLY-GMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKMFQEPLFA-EIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O35186|CATK_RAT (Cathepsin K OS=Rattus norvegicus OX=10116 GN=Ctsk PE=2 SV=1) HSP 1 Score: 288.886 bits (738), Expect = 2.764e-94 Identity = 145/320 (45.31%), Postives = 201/320 (62.81%), Query Frame = 1
Query: 169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
LL + +++ L+ QW+L+ K + K Y + E+ RR+IWE NLK I HNL+ LG +T+ L +N D+T E + P+++ +T P VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ +KTG+L++ S Q LVDC NYGC GG MT+AF ++ GGI+SE YPY Q +C++N + GY+EI NE +L AVA GP+SV I SL +FQ Y GVY + +C R NH VLVVGYGT + YWI+KNSWG WG KGY+ ++++K+N C I + ASFP
Sbjct: 8 LLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P55097|CATK_MOUSE (Cathepsin K OS=Mus musculus OX=10090 GN=Ctsk PE=1 SV=2) HSP 1 Score: 288.886 bits (738), Expect = 3.047e-94 Identity = 145/320 (45.31%), Postives = 200/320 (62.50%), Query Frame = 1
Query: 169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
LL + +++ L+ QW+L+ K + K Y + E+ RR+IWE NLK I HNL+ LG++T+ L +N D+T E + P+++ +T P VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ +KTG+L++ S Q LVDC NYGC GG MT+AF ++ GGI+SE YPY Q +C++N + GY+EI NE +L AVA GPISV I SL +FQ Y GVY + +C R NH VLVVGYGT +WI+KNSWG WG KGY ++++K+N C I + ASFP
Sbjct: 8 LLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1) HSP 1 Score: 347.436 bits (890), Expect = 1.407e-114 Identity = 179/337 (53.12%), Postives = 244/337 (72.40%), Query Frame = 1
Query: 142 MRILTVTP-YLLSFFAI--SIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP---NKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M+I+ +T +L++ A+ +N ELND+W++Y ++K YE +E+ RR+IWE+NLK+I +HN+++DLG +T+ LG+N+FAD+TH EFKA YL L+P N T + ++ P N ++P +DW KGYVT VK+QG+CGSCWAFSTTGSLEGQ FRK+G+LVSFSEQQLVDCS S N GC+GGLM +AF+ I+ GIE+E YPY A C ++++K+V + +G+ +I NE L AVA +GPISV I S + FQ Y+ G+YNEP C S+ +HGVL +GYG+ N+NYWIVKNSW WGM GYI MSKDK NQC IA+ AS+P++
Sbjct: 1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYET-LNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLG--LKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKF-GIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1) HSP 1 Score: 340.117 bits (871), Expect = 8.831e-112 Identity = 175/312 (56.09%), Postives = 215/312 (68.91%), Query Frame = 1
Query: 199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
LELN++W+ Y + K YE EL+RR+IWE NL++I KHNL++D G++++TLG+NQF DLT EFKA YLS G+ +LP N ++P VDW KGYVT VKDQ +CGSCWAFSTTGSLEGQ F+KTG LVS SEQ LVDCS N GC+GGLM + F IK GI++E YPYKA+ C F S V +VSG+ +I +NE +L AVA GPISV I +FQLYKSGVY+E CS +HGVL VGYGT YW+VKNSWG WGMKGYI MS++K NQC IAS AS+P++
Sbjct: 21 FTLELNEEWEAYKSTHGKVYEAD-EELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 339.732 bits (870), Expect = 1.238e-111 Identity = 175/312 (56.09%), Postives = 215/312 (68.91%), Query Frame = 1
Query: 199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
LELN++W+ Y + K YE EL+RR+IWE NL++I KHNL++D G++++TLG+NQF DLT EFKA YLS G+ +LP N ++P VDW KGYVT VKDQ +CGSCWAFSTTGSLEGQ F+KTG LVS SEQ LVDCS N GC+GGLM + F IK GI++E YPYKA+ C F S V +VSG+ +I +NE +L AVA GPISV I +FQLYKSGVY+E CS +HGVL VGYGT YW+VKNSWG WGMKGYI MS++K NQC IAS AS+P++
Sbjct: 21 FTLELNEEWEAYKSTHGKVYEAD-EELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1Z5KUE4 (Uncharacterized protein (Fragment) OS=Ornithodoros moubata OX=6938 PE=3 SV=1) HSP 1 Score: 338.576 bits (867), Expect = 3.477e-111 Identity = 171/334 (51.20%), Postives = 229/334 (68.56%), Query Frame = 1
Query: 136 FQMRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNA---FNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+R+L V+ + A ++ +LN W++Y +++ K Y P E RR+IWEDNL +I KHNL++DLGL+T+ +G+N FADLT E++ +L R N+T L A +++P +VDW E+GYVT VK+QG+CGSCWAFS TGSLEGQ FRKTG+LVS SEQ LVDC ++ GC+GG M SAF ++ GGI++E YPY A C FN S V + GY +++ +E L AVA GP+SV I S N FQ Y+SGVYNEPDC S+ +HGVLVVGYGT +++YWIVKNSWG WG +GYI MS+++DNQC IAS AS+P++
Sbjct: 1 MSLRLLVVSAIVACALARTVP-RPQLNAHWEVYKEVHQKKY-GPGEENRRRLIWEDNLDFIQKHNLEYDLGLHTYRVGVNSFADLTSKEYRETFL--GYRHNRTRKVPLATHQAISLYDLPEHVDWREEGYVTPVKNQGQCGSCWAFSATGSLEGQHFRKTGKLVSLSEQNLVDCDQTSDGCNGGSMDSAFQYVQSNGGIDTESSYPYVAHDEACEFNPSTVGATDKGYHDVESGSEDDLQSAVATVGPVSVAIDASQNSFQFYQSGVYNEPDCSSKSLDHGVLVVGYGTLNDEDYWIVKNSWGEAWGDEGYILMSRNRDNQCGIASDASYPLV 330
BLAST of Cathepsin L2 vs. TrEMBL
Match: W4YG82 (Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=3 SV=1) HSP 1 Score: 332.413 bits (851), Expect = 8.298e-109 Identity = 172/334 (51.50%), Postives = 225/334 (67.37%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY----LSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ +L V ++S ++S + ++ W + + K Y + E RR+IW+ NL + KHNL +DLG +T+ LGINQFADL + EF A+ +SG + K G+T+LPP N +P VDW KGYVT VKDQG+CGSCWAFSTTGS+EGQ F+ TG+LVS SEQ LVDCS + GC GG M AF I D GGI++E YPYKA C F ++ V +V+GY ++ +E +L AVA+ GPISV I S ++FQ YKSGVYNEP C S V +HGVL VGYGTS + +YWIVKNSW WGM GY+WMS++KDNQC IA+ AS+P++
Sbjct: 4 LSVLLVAACVVSSLSMSFT---DFDEDWNEWKNEHGKRYLSDEEEASRRLIWQKNLDIVIKHNLKYDLGHFTYDLGINQFADLQNEEFVAMMTGFRVSGTSKAAK-GSTFLPPNNVGELPKTVDWRTKGYVTPVKDQGQCGSCWAFSTTGSVEGQHFKATGKLVSLSEQNLVDCSGRDAGCDGGFMDRAFQYIIDAGGIDTEASYPYKAVDGKCHFKKANVGATVTGYTDVTSGSEKALQKAVAHVGPISVAIDASHMSFQHYKSGVYNEPGCDSTVLDHGVLAVGYGTSSDGTDYWIVKNSWAETWGMNGYVWMSRNKDNQCGIATNASYPLV 333
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700]) HSP 1 Score: 293.893 bits (751), Expect = 4.915e-97 Identity = 162/339 (47.79%), Postives = 214/339 (63.13%), Query Frame = 1
Query: 148 ILTVTPYLLSFFAISI---ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
LT+ L F +L+ +L+D WKL+ ++K+Y E RR++WE NLK + HNL+H +G +T+ LG+NQFAD+T+ EF+ PNK G+ +L P + VP VDW EKGYVT VKDQ +CGSCWAFS+TG+LEGQ FRKTG+LVS SEQ LVDCS N GC+GG+M AF +KD GGI+SE+ YPY A+ C ++ + + +G+ +I E +L AVA GP+SV I +FQ Y+SG+Y E CS +HGVLVVGYG D YWIVKNSW WG GYI+M+KD+ N C IAS AS+P++
Sbjct: 2 FLTLASLLALCFCTGFTAPSLDRQLDDHWKLWKSWHSKSYHEK-EEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEP-SFLEVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000047972.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000030.1:138766:150097:-1 gene:ENSAMXG00000038942.1 transcript:ENSAMXT00000047972.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 287.345 bits (734), Expect = 1.370e-94 Identity = 148/308 (48.05%), Postives = 196/308 (63.64%), Query Frame = 1
Query: 220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS--GNLRPNKTGNT--YLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+WKL + K+Y + E R+MIW NLK + +HN+ D GL + LG+N FAD+ + EF+ + G+ K N + VP VDW +GYVT+VK QG CGSCWAFS+TG+LEGQ F+KTG LVS SEQQLVDCS S N GC+GGLM+ AFN + + GG+++E YPY+ Q C FN+ V + SGY I +E L V GP+SV + ++FQLY+SG+Y+E DCS NHGVL VGYG+ +YW+VKNSW WG GYI MS++K+NQC IA+FA +P +
Sbjct: 26 EWKLK---FGKSYSSEAEESQRKMIWMTNLKLVLEHNMLADQGLKSHRLGMNHFADMENQEFRKMLSRCLGSFDTTKIHNATKFTGKAGGAAVPDTVDWRTQGYVTEVKSQGLCGSCWAFSSTGALEGQMFKKTGSLVSLSEQQLVDCSESYGNNGCNGGLMSYAFNYVMNNGGLDTEASYPYEGQDSVCRFNQYSVGATCSGYTFISSGSEEELKEVVGTVGPVSVAVDAEVSFQLYQSGIYDESDCSSTQLNHGVLAVGYGSQNGKDYWLVKNSWSTSWGEAGYIRMSRNKNNQCGIATFALYPEV 330
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000001927.2 (cathepsin L1-like [Source:NCBI gene;Acc:107197646]) HSP 1 Score: 286.574 bits (732), Expect = 3.548e-94 Identity = 162/339 (47.79%), Postives = 214/339 (63.13%), Query Frame = 1
Query: 142 MRIL-TVTPYLLSFFAISIAL-NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-----KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGI-SVSLNFQLYKSGVYNEPDCSRV-PNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
MR+L TVT + A S++L +LE +WKL Y K+Y++ E R+MIW NLK + +HN+ D GL T+ LG+N FAD+ E++ ++ G LRP+ ++ +L +P ++DW + GYV++VK QG C SCWAFS G+LEGQ FRKTG LVS S QQLVDCS N GC GG M AF I GG+E+E +YPYKA++ C+FN V ++E+ + E L AV GP+SV I S + F LY+SG+YNEP CS NHGVLVVGY T S YW+VKNSWG WG +GYI MS++KDNQC IA+ ASFP++
Sbjct: 1 MRVLLTVTTLVAVVSATSVSLEDLEFQ-EWKLK---YGKSYDSEEEESQRKMIWMTNLKLVLEHNMLADQGLKTYRLGMNHFADMDDQEYQQMF-RGYLRPSNRTKPRSAGRFLQQAENVALPYSIDWRDNGYVSNVKTQGHCASCWAFSAAGALEGQMFRKTGSLVSLSMQQLVDCSWLDGNDGCGGGSMELAFEYISRSGGLETESDYPYKAREGMCMFNPQDVSGKCHDFEELPKGEEKDLQKAVVAVGPVSVAIDSSNKTFLLYQSGIYNEPYCSSYNVNHGVLVVGYNTDSSGREYWVVKNSWGVQWGEQGYIRMSRNKDNQCGIATRASFPLV 334
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607]) HSP 1 Score: 280.796 bits (717), Expect = 6.299e-92 Identity = 150/308 (48.70%), Postives = 197/308 (63.96%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS--GNLRPNK--TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
WKL + K Y + E R++ W N K + HN+ D G+ ++ LG+ FAD+ + E++ ++ S G+ K + T+L +P VDW KGYVTD+KDQ CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS N+GC GGLM AF IK GI++E YPY+A +C F V + +G+ +I +E +L AVA GPISV I +FQLY+SG+YNEPDCS +HGVL VGYGT +YW+VKNSWG WG KGYI MS+++DNQC IA+ +S+P++
Sbjct: 29 WKLK---FGKIYHSVEEESQRKLTWLTNRKLVLVHNMLADQGIKSYRLGMTFFADMDNKEYRKLFASCLGSFNRTKAHSATTFLRQTLRDPLPDTVDWRPKGYVTDIKDQKDCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNFGCGGGLMDQAFEYIKANKGIDTEDSYPYEAVDGDCRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGTDNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYPLV 333
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103027561]) HSP 1 Score: 279.641 bits (714), Expect = 1.977e-91 Identity = 154/306 (50.33%), Postives = 196/306 (64.05%), Query Frame = 1
Query: 244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTG------NTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDN---YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ K+Y++ E R+MIW +N K + +HN+ D GL ++ LG+N FAD+ + EF+A++ + N T +T++P +P VDW KGYVTDVK+Q CGSCWAFS TGSLEGQ FRKT RL+S SEQQLVDCS N+GC+GGL AFN I+ G+E++ YPYKAQ C FN KV + G + NE +L IAVA GPISV I S + FQLYKSGVY+EP CS NH VL+VGYG N N YW+VKNSWG WG GYI MS++K NQC IA +P++
Sbjct: 33 HGKSYDSEEEESERKMIWLNNRKLVLEHNMLADQGLKSYRLGMNIFADMENQEFQAMFSNCVESLNDTDTDSLCTSTFVPEKEGSALPCRVDWRRKGYVTDVKNQRNCGSCWAFSATGSLEGQMFRKTRRLISLSEQQLVDCSRCFGNHGCNGGLAIWAFNYIRSSKGLEADFTYPYKAQDRRCHFNPWKVRATCRGTVCLPRGNEIALKIAVARVGPISVSIDASKHTFQLYKSGVYDEPRCSNNRLNHAVLLVGYGRIRNRNRKQYWLVKNSWGTRWGENGYIRMSRNKMNQCGIAKRPVYPLV 338
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 299.286 bits (765), Expect = 2.539e-100 Identity = 159/299 (53.18%), Postives = 200/299 (66.89%), Query Frame = 1
Query: 250 KTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
KTY+ E RRMIWE NLK I HNL+H +G +T+ +G+N+F D+T EF+ L S + G T++ P F P +VDW ++GYVTDVKDQG CGSCWAFSTTGSLEGQ RKTG LVS SEQ LVDCS + N GC GGLM AF IK GGI+SE YPY A+ NC +N +G+ +I NE +L AVA+ GP+S+GI SL +FQLY SG+Y++ DCS +HGVLVVGYG ++ +WIVKNSWG WG GYI M++DKDN C IA+ AS+P++
Sbjct: 1 KTYDQN-EEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLRGSNDTSKASRGATFMAPA-FFKAPESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSNNLDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 290.426 bits (742), Expect = 5.720e-97 Identity = 153/289 (52.94%), Postives = 194/289 (67.13%), Query Frame = 1
Query: 283 RRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS----GNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQL-NCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVPNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
RRMIWE NLK I HNL+H +G +T+ +G+N+F D+T EF+ + L G T++ P F P +VDW ++GYVTDVK+QG CGSCW+FSTTGSLEGQ RKTG LVS SEQ LVDCS + NYGC+GGLM +AFN IK GGI+SE+ YPYK Q + C +N V+GY EI E +E +L AVA+ GP+SV I SLN F Y SG+Y + CS + NH VLVVGYG D +W+VKNSWG WG KGY+ M++D +N C IA AS+P++
Sbjct: 8 RRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPA-FFEAPESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLCSHIINHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYPLV 295
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 290.041 bits (741), Expect = 3.415e-96 Identity = 164/342 (47.95%), Postives = 224/342 (65.50%), Query Frame = 1
Query: 142 MRIL-TVTPYLLSFFAISIAL-NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSG--NLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGY---GTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M +L ++ P LL+ A + + + L+++W + + K YE P E RRMIWE NL I HNL+H LG +T+ +G+N F D+T+ EF+ ++G ++P+K G+T+L P N + P VDW +KG VT+VKDQG+CGSCWAFSTTG+LEGQ RK G+LVS SEQ LVDCS + N GC GGLM AF +KD GGI+SE YPY + C ++ + +G+ ++ +E +L IAVA+ GP+SV I S +FQ Y+SGVY EPDCS +HGVLVVGY GT N YWIVKNSW P WG +GY+ M+++K N C IA+ AS+P++
Sbjct: 1 MNVLWSLVPALLAVMASATPIHDPMLDEEWGSWKGFHQKLYE-PKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQ-KMNGYHGVQPHKVSKGSTFLVPQN-YEAPPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 287.345 bits (734), Expect = 9.611e-96 Identity = 147/289 (50.87%), Postives = 199/289 (68.86%), Query Frame = 1
Query: 283 RRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYL-----SGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
RR+IWE NLK I HNL+H +G +T+ +G+NQF+D+T EF+ + L +G + + G T++ P F P +VDW ++GYVTD+K+QG CGSCW+FSTTGSLEGQ RKTG LVS SEQ LVDCS + N+GC+GGLM +AFN IK GGI+SE+ YPYK Q C ++ V+GY EI E +E +L AVA+ GP+SV I SL +FQ Y SG+Y + CS +H VLVVGYG + +W+VKNSWG WG +GY+ M++D +N C IA+ +S+P++
Sbjct: 7 RRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPR-GATFMAPA-FFEAPESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMCSHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007755.1 (pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 gene:ENSPMAG00000007008.1 transcript:ENSPMAT00000007755.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 268.855 bits (686), Expect = 6.412e-88 Identity = 150/309 (48.54%), Postives = 192/309 (62.14%), Query Frame = 1
Query: 220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEF--KAIYLSGNLRPNKTGNTYLP-PLNAF-NVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNY--GCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYK--EIDENEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
QW + Y K Y + + RR ++E NLK + +HNL D G +F LGIN+++DL E+ K + NLR N T P PL + N+P VDW KGYVT VK+QG CGS WAFS TGSLEGQ F TG L S SEQQLVDC+ S Y GC+GG A I D GI+SE YPY+ C F + V T S Y+ E NE L AVA+ GPI++ ++ L+ F+ YKSG++NEP C + PNH +LVVGYG+ +++WIVKNSWG WG KGYI+M ++KDNQC IAS +P+I
Sbjct: 26 QWDTWKSTYGKHYGSEQEDAHRRDVFEQNLKRVLQHNLLADEGNVSFHLGINKYSDLELHEYHEKVVGRFWNLR-NGTRRRGAPFPLRSMDNLPEQVDWRLKGYVTPVKEQGLCGSSWAFSATGSLEGQHFAATGNLTSLSEQQLVDCTKSYYNNGCNGGRSERALQYIIDNNGIDSELSYPYEHADGKCRFKPANVATKCSSYQFVEPSSNEEVLRQAVASVGPIAIAMNADLDTFKHYKSGLFNEPSCDKSPNHAMLVVGYGSLSGNDFWIVKNSWGEDWGEKGYIYMIRNKDNQCGIASIGIYPII 333
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5]) HSP 1 Score: 311.227 bits (796), Expect = 2.381e-104 Identity = 160/310 (51.61%), Postives = 204/310 (65.81%), Query Frame = 1
Query: 205 LELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L + QW + + KTY E +RR IW DNL+ + KHN ++ +++ L +N FADLT EFK ++ N TG + PL+ +PA VDW +KG+VT VK+QG+CGSCWAFS+TGSLEGQ FRKTG+LVS SEQ LVDCS N GC GGLM AF IK+ GI++EQ YPY A+ C F V +V+GY ++ +EG L AVA GPISV I +FQLYK+GVY+EPDCS +HGVL VGYG +YW+VKNSWG WGM GYI MS++KDNQC IA+ AS+P++
Sbjct: 21 LSQDRQWHAWKDFHGKTYTGE-EEDLRRAIWNDNLEIVKKHNAEN----HSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFLPLSNVQLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1]) HSP 1 Score: 293.123 bits (749), Expect = 3.339e-97 Identity = 155/337 (45.99%), Postives = 209/337 (62.02%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN------KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M++L L + + + E QW+ + + K Y E R+ IW DNLK I KHN + ++FTL +N DLT EF+ Y +R + K G+ +L P + VP VDW ++GYVT VK+QG+CGSCWAFSTTGSLEGQ F+KTG+LVS SEQ LVDCS + N GC GGLM AF IK+ GGI++E+ YPY+A+ C F +S + +G+ ++ +E +L A GPISV I ++FQ Y SGVYN CS +HGVLVVGYGT +YW+VKNSWG WGM+GYI MS++K+NQC +A+ AS+P++
Sbjct: 1 MKLLVAACLLFAVASGFVVKFDEDEQQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAEG----HSFTLAMNHLGDLTQDEFRYFYTG--MRSHYSNYTKKQGSAFLAPSHV-QVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6]) HSP 1 Score: 292.738 bits (748), Expect = 3.684e-97 Identity = 150/315 (47.62%), Postives = 206/315 (65.40%), Query Frame = 1
Query: 196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGN---TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
++ + +W + + K+Y + E R IW+ NL+ I +HN + +++ + +N DLT EF+ YL N T TY+PP N +P++VDW++KGYVT VK+QG+CGSCWAFSTTGS+EGQ FRKTG LVS SEQ L+DCS S N GC GGLM +AF I+ GGI++E YPY QQ +C F+ S V V+GY++I + +E +L AVA GP+SV + S +Q Y SGVY+ P CS +HGVLV+GYG +YW+VKNSWG WG++GYI MS++K+NQC IAS AS+P++
Sbjct: 18 SVRFGQDSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAED----HSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSNV-KIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDAS-QWQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9]) HSP 1 Score: 277.715 bits (709), Expect = 3.235e-91 Identity = 145/308 (47.08%), Postives = 197/308 (63.96%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNK----TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
WK + + K Y N E +R IW++NLK I HN G ++F L +N D+T E L L+ + G T+LPP N V ++DW KGYVT VK+QG+CGSCWAFSTTG+LEGQ FRKTG+LVS SEQ LVDCS N GC GGLM +AF IK+ GGI++E+ YPY A+ C +N+S + +G+ +I +E +L A+A+ GPIS+ I S + F Y GVY++PDCS +HGVL VGYGT +YW+VKNSWGP WG +GYI ++++ ++C +AS AS+P++
Sbjct: 29 WKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHNE----GKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPAN-VKVVDSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO42751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0K3]) HSP 1 Score: 206.068 bits (523), Expect = 3.948e-64 Identity = 114/259 (44.02%), Postives = 157/259 (60.62%), Query Frame = 1
Query: 292 IWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEF-KAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGY 1053
I+E N++ K +D Y T+ F+DL+ EF K + G +P PL ++P +VDW +KG VT VK+QG CGSCWAFSTTG++EGQ+ KTG+LVS SEQ+LVDC + GC GGL ++A+ I+ LGG+ESE +YPYK C FN+++V +++ I ++E +A +A GPIS+GI+ + Q Y G+ + P NHGVL+VGYG YWI+KNSWGP WG KGY
Sbjct: 3 IFESNMRKAAKMQKMDSGTAQYGPTI----FSDLSEEEFRKQKMMPGWGKPLYEMKDAEIPLG--DIPESVDWRDKGVVTPVKNQGSCGSCWAFSTTGNIEGQYAIKTGKLVSLSEQELVDCDTIDKGCEGGLPSNAYKQIEKLGGLESESDYPYKGADSKCKFNKAEVKVTINSSVVISKDEKEIAAWLAKNGPISIGINANA-MQFYMGGIAHPWKIFCNPSSLNHGVLIVGYGVKNGTPYWIIKNSWGPSWGEKGY 254
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789]) HSP 1 Score: 295.434 bits (755), Expect = 1.287e-97 Identity = 152/309 (49.19%), Postives = 203/309 (65.70%), Query Frame = 1
Query: 223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSG-----NLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
W+L + +TY +P E RR W +N K + HN+ D G+ ++ LG+ FAD+ + E+K + G N + G+T+ ++PA VDW +KGYVTDVKDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS N GC GGLM AF I+ GGI++E+ YPY+A+ C + V + +GY ++ +E +L AVA GPISVGI S ++FQLY+SG+Y+EP CS +HGVL VGYG+ +YW+VKNSWG WG +GYI MSK+K NQC IA+ AS+P++
Sbjct: 34 WRLK---FGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENKDLPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246]) HSP 1 Score: 283.878 bits (725), Expect = 3.903e-93 Identity = 152/319 (47.65%), Postives = 204/319 (63.95%), Query Frame = 1
Query: 199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNK--TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKA-QQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
L+ +L+ W+L+ ++K Y E RR++WE NL+ I HNL+H +G +++ LG+N F D+TH EF+ I R + +G+ ++ P N P VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ FRKTG+LVS SEQ LVDCS N GC+GGLM AF +KD G++SE YPYK C +N + +G+ +I E +L AVA+ GP+SV I +FQ Y+SG+Y E +CS +HGVLVVGYG D YWIVKNSW WG KG+I+M+KD+ N C IA+ AS+P++
Sbjct: 20 LDPQLDQHWQLWKGWHSKNYHEK-EEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEP-NFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsk (cathepsin K [Source:NCBI gene;Acc:101164922]) HSP 1 Score: 269.626 bits (688), Expect = 1.269e-87 Identity = 143/330 (43.33%), Postives = 197/330 (59.70%), Query Frame = 1
Query: 154 TVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAE----FKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
T LLS +S L+ W+ + + K Y E IRR IWE NL+ I HN + LG++T+TLG+NQF D+T E + + N P T + +P +VD+ +KG VT VK+QG CGSCWAFS+ G+LEGQ +KTG LV S Q LVDC N GC GG MT+AF +++ GGI+SE YPY + C +N S + + GYKE+ E +E +LA+A+ GP+SVGI S N F Y+ G+Y + +C++ NH VL VGYG + +WIVKNSWG WG KGY+ M++++ N C IA+ AS+PV+
Sbjct: 5 TCVLLLLSASVMSQMDETTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGLQMPLNPEPRVPMET---DGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTENDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYPVM 331
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247]) HSP 1 Score: 264.618 bits (675), Expect = 1.074e-85 Identity = 142/314 (45.22%), Postives = 190/314 (60.51%), Query Frame = 1
Query: 196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTY--LPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
A+ L+ W L+ K Y+KTY + E RR IWE+NL+ I HNL+ LGL+++ L +N DLT E A L+G + P + L +N +VP +VDW E G VT VK QG+CGSCWAFS G+LEGQ + TG L S S Q LVDCS NYGC GG M++AF + GI S+ YPY ++ C ++ + +GY + + +E +L + VA GPISV I S F Y+ GVY + CS NHGVLVVGYGT ++YW+VKNSWG +G GYI M++++ NQC IA +A FPV+
Sbjct: 16 AVRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIA-SLTGTVAPVGLERIHYDLVKINT-SVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSCSHNVNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175]) HSP 1 Score: 259.225 bits (661), Expect = 1.574e-83 Identity = 135/316 (42.72%), Postives = 192/316 (60.76%), Query Frame = 1
Query: 196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP----NKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
A + L+ W+L+ K ++K Y + ++ RR +WE NL I HNL++ +GL+T+ L +N DLT E + S LRP + + ++ + N+P +DW +K VT VK QG CGSCWAFS G+LEGQ RKTG+LV S Q LVDCS N+GC+GG M AF + D GI+S+ YPY NC ++ + S Y + E +EG+L A+A GPISV I + F Y+SGVY++ CS+ NHGVL VGYGT +YW+VKNSWG +G +GYI M+++K++QC IA + +P++
Sbjct: 26 AFDSRLDIHWELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEILQQFAS--LRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSCSQNVNHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYPIM 339
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049781.1 (SMESG000049781.1) HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0 Identity = 318/326 (97.55%), Postives = 320/326 (98.16%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL+P KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFS TGSLEGQFFRKTGRLVSFSEQQLVDCS SN GCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNC FN SKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPV+
Sbjct: 1 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLKPTKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSATGSLEGQFFRKTGRLVSFSEQQLVDCSKSNNGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCEFNHSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVV 326
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049783.1 (SMESG000049783.1) HSP 1 Score: 650.973 bits (1678), Expect = 0.000e+0 Identity = 312/326 (95.71%), Postives = 317/326 (97.24%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQG CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS SN GC+GGLMTSAFNDIKDLGGIESEQEYPY+AQQLNCVFNRSKVVTSVSGYKEI +NEGSLAIAVANEGPISV I VSLNFQLYKSGVYNEPDCSRVPNH VLVVGYGTSVNDNYWIVKNSWGP WGMKGYIWMSKDKDNQCAIASFASFP++
Sbjct: 1 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPTKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGNCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSKSNNGCNGGLMTSAFNDIKDLGGIESEQEYPYQAQQLNCVFNRSKVVTSVSGYKEIYKNEGSLAIAVANEGPISVLIRVSLNFQLYKSGVYNEPDCSRVPNHAVLVVGYGTSVNDNYWIVKNSWGPSWGMKGYIWMSKDKDNQCAIASFASFPIV 326
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1) HSP 1 Score: 480.33 bits (1235), Expect = 3.656e-170 Identity = 227/331 (68.58%), Postives = 263/331 (79.46%), Query Frame = 1
Query: 130 VKFQMRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
+ QM T +L+ FF +LNLELNDQW+L+MKIYNK+YEN HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN +KTGNTYLPPLN+ +P VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I S +FQ YKSGVYNEP+C H VLVVGYGT DNYWIVKNSW WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct: 27 LSLQMNTYLATSFLICFFGKCFSLNLELNDQWRLFMKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 357
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1) HSP 1 Score: 477.248 bits (1227), Expect = 2.121e-169 Identity = 226/327 (69.11%), Postives = 261/327 (79.82%), Query Frame = 1
Query: 142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
M T +L+ FF +LNLELNDQW+L+MKIYNK+YEN HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN +KTGNTYLPPLN+ +P VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I S +FQ YKSGVYNEP+C H VLVVGYGT DNYWIVKNSW WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct: 1 MNTYLATSFLICFFGKCFSLNLELNDQWRLFMKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 327
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1) HSP 1 Score: 444.506 bits (1142), Expect = 5.910e-157 Identity = 211/296 (71.28%), Postives = 241/296 (81.42%), Query Frame = 1
Query: 235 MKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
MKIYNK+YEN HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN +KTGNTYLPPLN+ +P VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I S +FQ YKSGVYNEP+C H VLVVGYGT DNYWIVKNSW WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct: 1 MKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 296 The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30023109 ID=SMED30023109|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1207bpback to top protein sequence of SMED30023109-orf-1 >SMED30023109-orf-1 ID=SMED30023109-orf-1|Name=SMED30023109-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=327bp MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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