Cathepsin L2

Overview
NameCathepsin L2
Smed IDSMED30023109
Length (bp)1207
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cathepsin L2 (SMED30023109) t-SNE clustered cells

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30023109) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cathepsin L2 (SMED30023109) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30023109) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30023109

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 15

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
headSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 SmedASXL_016216SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
parenchymal cellSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v4_1363_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
epidermal cellSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v4_1363_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
headSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v6_1363_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
headSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 Contig41964uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
headSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 Contig41964newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
gutSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 SMED30023109smed_20140614PMID:26457503
Tu et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 SMED30023109smed_20140614PMID:26457503
Tu et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v4_1363_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
dorsal region of the epidermisSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v4_1363_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 dd_Smed_v4_1363_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019
whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30023109SMESG000049783.1 SMESG000049781.1 SMED_01698_V2_1rGPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30023109SMESG000049783.1 SMESG000049781.1 SMED_01698_V2_1rGPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 SMED_01698_V2_1rGPL14150_gene_modelsPMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30023109SMESG000049790.1 SMESG000049783.1 SMESG000049781.1 SMED_01698_V2_1rGPL14150PMID:22385657
Wagner et al., 2012
whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 298.901 bits (764), Expect = 9.287e-99
Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +  + L   + ++  +  L  QW  +  ++N+ Y     E  RR +WE N+K I  HN ++  G ++FT+ +N F D+T  EF+ +      R  + G  +  PL  +  P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS    N GC+GGLM  AF  ++D GG++SE+ YPY+A + +C +N    V + +G+ +I + E +L  AVA  GPISV I     +F  YK G+Y EPDCS    +HGVLVVGYG     S N+ YW+VKNSWG  WGM GY+ M+KD+ N C IAS AS+P +
Sbjct:    5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 298.901 bits (764), Expect = 9.287e-99
Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +  + L   + ++  +  L  QW  +  ++N+ Y     E  RR +WE N+K I  HN ++  G ++FT+ +N F D+T  EF+ +      R  + G  +  PL  +  P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS    N GC+GGLM  AF  ++D GG++SE+ YPY+A + +C +N    V + +G+ +I + E +L  AVA  GPISV I     +F  YK G+Y EPDCS    +HGVLVVGYG     S N+ YW+VKNSWG  WGM GY+ M+KD+ N C IAS AS+P +
Sbjct:    5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSK (cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536])

HSP 1 Score: 282.722 bits (722), Expect = 1.837e-92
Identity = 150/322 (46.58%), Postives = 201/322 (62.42%), Query Frame = 1
Query:  169 LLSFFAISIALNLE--LNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEF--KAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
            +L    +S AL  E  L+  W+L+ K + K Y N   E+ RR+IWE NLKYI  HNL+  LG++T+ L +N   D+T  E   K   L   L  +++ +T   P      P +VD+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ  +KTG+L++ S Q LVDC   N GC GG MT+AF  ++   GI+SE  YPY  Q+ +C++N +       GY+EI E NE +L  AVA  GP+SV I  SL +FQ Y  GVY +  C S   NH VL VGYG    + +WI+KNSWG  WG KGYI M+++K+N C IA+ ASFP
Sbjct:    6 VLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSS (cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545])

HSP 1 Score: 278.485 bits (711), Expect = 9.259e-91
Identity = 149/332 (44.88%), Postives = 199/332 (59.94%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGN-TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYG---CHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M+ L     + S     +  +  L+  W L+ K Y K Y+    E +RR+IWE NLK++  HNL+H +G++++ LG+N   D+T  E  ++  S  +      N TY    N   +P +VDW EKG VT+VK QG CG+CWAFS  G+LE Q   KTG+LVS S Q LVDCS   YG   C+GG MT+AF  I D  GI+S+  YPYKA    C ++      + S Y E+    E  L  AVAN+GP+SVG+     +F LY+SGVY EP C++  NHGVLVVGYG      YW+VKNSWG  +G +GYI M+++K N C IASF S+P I
Sbjct:    1 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRI-LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI 331          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 271.937 bits (694), Expect = 3.296e-88
Identity = 145/332 (43.67%), Postives = 201/332 (60.54%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +  + L   +     +  L+ +W  +   + + Y     E  RR +WE N+K I  HN ++  G + FT+ +N F D+T+ EF+ +      +  + G  +  PL   ++P +VDW +KGYVT VK+Q +CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS    N GC+GG M  AF  +K+ GG++SE+ YPY A    C +     V + +G+  +    E +L  AVA  GPISV +     +FQ YKSG+Y EPDC S+  +HGVLVVGYG     S N  YW+VKNSWGP WG  GY+ ++KDK+N C IA+ AS+P +
Sbjct:    5 LVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLY-GANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPL-FLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 266.544 bits (680), Expect = 1.936e-86
Identity = 142/311 (45.66%), Postives = 197/311 (63.34%), Query Frame = 1
Query:  217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAI----YLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++W  Y + ++K Y     E      +  N+ +I  HN DH LG  TF +G+N  ADL  ++++ +     L G+ R  K  +++L P N   VP  VDW +   VTDVK+QG CGSCWAFS TG+LEGQ  RK G+LVS SEQ LVDCS    N+GC+GGLM  AF  I+D  G+++E+ YPYK + + C FN+  V     GY +  E +E  L IAVA +GPIS+ I     +FQLYK GVY + +CS    +HGVL+VGYGT   + +YWIVKNSWG  WG KGYI ++++++N C +A+ AS+P++
Sbjct:   30 EKWDDYKEDFDKEYSES-EEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDSRI-KNSSSFLAPFNV-QVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 205.297 bits (521), Expect = 1.729e-64
Identity = 103/197 (52.28%), Postives = 137/197 (69.54%), Query Frame = 1
Query:  547 CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            CGSCWAFS TG+LEGQ  RK G+LVS SEQ LVDCS    N+GC+GGLM  AF  I+D  G+++E+ YPYK + + C FN+  V     GY +  E +E  L IAVA +GPIS+ I     +FQLYK GVY + +CS    +HGVL+VGYGT   + +YWIVKNSWG  WG KGYI ++++++N C +A+ AS+P++
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 205.297 bits (521), Expect = 1.729e-64
Identity = 103/197 (52.28%), Postives = 137/197 (69.54%), Query Frame = 1
Query:  547 CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTS-VNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            CGSCWAFS TG+LEGQ  RK G+LVS SEQ LVDCS    N+GC+GGLM  AF  I+D  G+++E+ YPYK + + C FN+  V     GY +  E +E  L IAVA +GPIS+ I     +FQLYK GVY + +CS    +HGVL+VGYGT   + +YWIVKNSWG  WG KGYI ++++++N C +A+ AS+P++
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 199.519 bits (506), Expect = 5.035e-59
Identity = 114/306 (37.25%), Postives = 169/306 (55.23%), Query Frame = 1
Query:  232 YMKIYNKTYENPFHELIRRMIWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGN--TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++  + K Y N    L R  +++ N K I +    +    +Y FT    +F+D+T  EFK I L       + P +  N   +   +N  ++P + DW EKG VT VK+QG CGSCWAFSTTG++EG +F    +LVS SEQ+LVDC   + GC+GGL ++A+ +I  +GG+E E  YPY  +   C   R  +   ++G  E+  +E  +   +  +GPIS+G++ +   Q Y+ GV +       P   NHGVL+VGYG      YWIVKNSWGP WG  GY  + + K N C +   A+  ++
Sbjct:  177 FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQKNEQGTAVYGFT----KFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSMDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN-TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 199.519 bits (506), Expect = 5.035e-59
Identity = 114/306 (37.25%), Postives = 169/306 (55.23%), Query Frame = 1
Query:  232 YMKIYNKTYENPFHELIRRMIWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGN--TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++  + K Y N    L R  +++ N K I +    +    +Y FT    +F+D+T  EFK I L       + P +  N   +   +N  ++P + DW EKG VT VK+QG CGSCWAFSTTG++EG +F    +LVS SEQ+LVDC   + GC+GGL ++A+ +I  +GG+E E  YPY  +   C   R  +   ++G  E+  +E  +   +  +GPIS+G++ +   Q Y+ GV +       P   NHGVL+VGYG      YWIVKNSWGP WG  GY  + + K N C +   A+  ++
Sbjct:  177 FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQKNEQGTAVYGFT----KFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSMDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPHDEVEMQKWLVTKGPISIGLNAN-TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592)

HSP 1 Score: 274.633 bits (701), Expect = 1.706e-89
Identity = 148/316 (46.84%), Postives = 202/316 (63.92%), Query Frame = 1
Query:  217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++W  +   + K Y++   E  R  I+ +N   I KHN     G  +F L +N++ADL H EF+ +       L   LR       G T++ P +   +P +VDW  KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS    N GC+GGLM +AF  IKD GGI++E+ YPY+A   +C FN+  V  +  G+ +I + +E  +A AVA  GP+SV I  S  +FQ Y  GVYNEP C ++  +HGVLVVG+GT  + ++YW+VKNSWG  WG KG+I M ++K+NQC IAS +S+P++
Sbjct:   27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593)

HSP 1 Score: 275.018 bits (702), Expect = 2.775e-89
Identity = 148/316 (46.84%), Postives = 202/316 (63.92%), Query Frame = 1
Query:  217 DQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++W  +   + K Y++   E  R  I+ +N   I KHN     G  +F L +N++ADL H EF+ +       L   LR       G T++ P +   +P +VDW  KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS    N GC+GGLM +AF  IKD GGI++E+ YPY+A   +C FN+  V  +  G+ +I + +E  +A AVA  GP+SV I  S  +FQ Y  GVYNEP C ++  +HGVLVVG+GT  + ++YW+VKNSWG  WG KG+I M ++K+NQC IAS +S+P++
Sbjct:   57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955)

HSP 1 Score: 270.781 bits (691), Expect = 4.689e-88
Identity = 147/307 (47.88%), Postives = 198/307 (64.50%), Query Frame = 1
Query:  244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY------LSGNLRPNK---TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            + K Y++   E  R  I+ +N   I KHN     G  +F L +N++ADL H EF+ +       L   LR       G T++ P +   +P +VDW  KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS    N GC+GGLM +AF  IKD GGI++E+ YPY+A   +C FN+  V  +  G+ +I + +E  +A AVA  GP+SV I  S  +FQ Y  GVYNEP C ++  +HGVLVVG+GT  + ++YW+VKNSWG  WG KG+I M ++K+NQC IAS +S+P++
Sbjct:   33 HRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021)

HSP 1 Score: 238.424 bits (607), Expect = 1.116e-76
Identity = 124/230 (53.91%), Postives = 164/230 (71.30%), Query Frame = 1
Query:  448 GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            G T++ P +   +P +VDW  KG VT VKDQG CGSCWAFS+TG+LEGQ FRK+G LVS SEQ LVDCS    N GC+GGLM +AF  IKD GGI++E+ YPY+A   +C FN+  V  +  G+ +I + +E  +A AVA  GP+SV I  S  +FQ Y  GVYNEP C ++  +HGVLVVG+GT  + ++YW+VKNSWG  WG KG+I M ++K+NQC IAS +S+P++
Sbjct:   21 GVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG12163 (gene:FBgn0260462 transcript:FBtr0078822)

HSP 1 Score: 210.69 bits (535), Expect = 3.219e-63
Identity = 121/305 (39.67%), Postives = 181/305 (59.34%), Query Frame = 1
Query:  244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFK---AIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYN--EPDCSRVP-NHGVLVVGYGTSVNDN------YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            + + Y +     +R  I+  NLK I + N + ++G   +  GI +FAD+T +E+K    ++     +    G+  + P     +P   DW +K  VT VK+QG CGSCWAFS TG++EG +  KTG L  FSEQ+L+DC  ++  C+GGLM +A+  IKD+GG+E E EYPYKA++  C FNR+     V+G+ ++ + NE ++   +   GPIS+GI+ +   Q Y+ GV +  +  CS+   +HGVLVVGYG S   N      YWIVKNSWGP WG +GY  + +  DN C ++  A+  V+
Sbjct:  176 FGRRYVSTAERQMRLRIFRQNLKTIEELNAN-EMGSAKY--GITEFADMTSSEYKERTGLWQRDEAKAT-GGSAAVVPAYHGELPKEFDWRQKDAVTQVKNQGSCGSCWAFSVTGNIEGLYAVKTGELKEFSEQELLDCDTTDSACNGGLMDNAYKAIKDIGGLEYEAEYPYKAKKNQCHFNRTLSHVQVAGFVDLPKGNETAMQEWLLANGPISIGINANA-MQFYRGGVSHPWKALCSKKNLDHGVLVVGYGVSDYPNFHKTLPYWIVKNSWGPRWGEQGYYRVYRG-DNTCGVSEMATSAVL 474          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101
Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            WKL    + K+Y +   E  R++ W  N K +  HN+  D GL ++ LG+  FAD+++ E++ +   G L        + G+T+     A  VP  VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S  NYGC GGLM  AF  I+   G+++E  YPY+AQ   C FN S V  S +GY +I   +E +L  AVA  GPISV I     +FQLY SGVYNEPDCS    +HGVL VGYG+S  D+YWIVKNSWG  WG++GYI MS++K NQC IA+ AS+P++
Sbjct:   29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101
Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            WKL    + K+Y +   E  R++ W  N K +  HN+  D GL ++ LG+  FAD+++ E++ +   G L        + G+T+     A  VP  VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S  NYGC GGLM  AF  I+   G+++E  YPY+AQ   C FN S V  S +GY +I   +E +L  AVA  GPISV I     +FQLY SGVYNEPDCS    +HGVL VGYG+S  D+YWIVKNSWG  WG++GYI MS++K NQC IA+ AS+P++
Sbjct:   29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 303.908 bits (777), Expect = 7.288e-101
Identity = 160/309 (51.78%), Postives = 204/309 (66.02%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL-----RPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            WKL    + K+Y +   E  R++ W  N K +  HN+  D GL ++ LG+  FAD+++ E++ +   G L        + G+T+     A  VP  VDW +KGYVTD+KDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS S  NYGC GGLM  AF  I+   G+++E  YPY+AQ   C FN S V  S +GY +I   +E +L  AVA  GPISV I     +FQLY SGVYNEPDCS    +HGVL VGYG+S  D+YWIVKNSWG  WG++GYI MS++K NQC IA+ AS+P++
Sbjct:   29 WKLK---FGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 296.975 bits (759), Expect = 3.314e-98
Identity = 158/337 (46.88%), Postives = 220/337 (65.28%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M  L VT Y+ + FA + +++++L+D W  +   + K+Y     E+ RRMIWE+NL+ I +HN ++ LG +TF +G+NQF D+T+ EF+         PN+T  G  ++ P   F  P  VDW ++GYVT VKDQ +CGSCW+FS+TG+LEGQ FRKTG+L+S SEQ LVDCS    N GC+GGLM  AF  +K+  G++SEQ YPY A+  L C ++    V  ++G+ +I + NE +L  AVA  GP+SV I  S  + Q Y+SG+Y E  C+   +H VLVVGYG    D     YWIVKNSW   WG KGYI+M+KDK+N C IA+ AS+P++
Sbjct:    2 MFALLVTLYISAVFA-APSIDIQLDDHWNSWKSQHGKSYHEDV-EVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEP-KFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52])

HSP 1 Score: 296.975 bits (759), Expect = 3.314e-98
Identity = 158/337 (46.88%), Postives = 220/337 (65.28%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M  L VT Y+ + FA + +++++L+D W  +   + K+Y     E+ RRMIWE+NL+ I +HN ++ LG +TF +G+NQF D+T+ EF+         PN+T  G  ++ P   F  P  VDW ++GYVT VKDQ +CGSCW+FS+TG+LEGQ FRKTG+L+S SEQ LVDCS    N GC+GGLM  AF  +K+  G++SEQ YPY A+  L C ++    V  ++G+ +I + NE +L  AVA  GP+SV I  S  + Q Y+SG+Y E  C+   +H VLVVGYG    D     YWIVKNSW   WG KGYI+M+KDK+N C IA+ AS+P++
Sbjct:    2 MFALLVTLYISAVFA-APSIDIQLDDHWNSWKSQHGKSYHEDV-EVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEP-KFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216])

HSP 1 Score: 298.901 bits (764), Expect = 6.491e-99
Identity = 152/330 (46.06%), Postives = 204/330 (61.82%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCS-RVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M   ++  + LS   I +     L+ +W+L+ K Y++ Y     E+ RR IWE NL  I +HN +   GL+T+ L +N   D+T  E     +   + PN +  NTY+P  N+  +P  +D+ +KGYVT V +QG CGSCWAFS+ G+LEGQ  +KTG+LVS S Q LVDC   NYGC GG MT+AF  ++D GGI+S+ EYPY  Q   C +N +    +  GYKEI   +E +L  AVAN GP+SV I  SL +FQ YK GVY +  C+    NH VLVVGYG      +WI+KNSWG  WG KGY+ +++DK N C IAS ASFPV+
Sbjct:    1 MWWFSLLSFALSLVKIGLCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWNS-RIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDTDNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 329          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216])

HSP 1 Score: 299.286 bits (765), Expect = 7.631e-99
Identity = 152/330 (46.06%), Postives = 204/330 (61.82%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCS-RVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M   ++  + LS   I +     L+ +W+L+ K Y++ Y     E+ RR IWE NL  I +HN +   GL+T+ L +N   D+T  E     +   + PN +  NTY+P  N+  +P  +D+ +KGYVT V +QG CGSCWAFS+ G+LEGQ  +KTG+LVS S Q LVDC   NYGC GG MT+AF  ++D GGI+S+ EYPY  Q   C +N +    +  GYKEI   +E +L  AVAN GP+SV I  SL +FQ YK GVY +  C+    NH VLVVGYG      +WI+KNSWG  WG KGY+ +++DK N C IAS ASFPV+
Sbjct:    8 MWWFSLLSFALSLVKIGLCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWNS-RIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCDTDNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 336          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 287.345 bits (734), Expect = 2.885e-94
Identity = 152/333 (45.65%), Postives = 213/333 (63.96%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDN----YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +    L+    +   +  L++ W L+   + K+Y  P  E  RR++WE NL+ I  HNL+H LG ++ +LG+NQF D+T+ EF+ +      +    G+T+L P N F  P +VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ +R TG+++S SEQ LVDCS +  N GC+GGLM  AF  +KD GGI+SE  YPY A+    C ++ +    + +G+ ++   +E  L  AVA+ GP+SV +     +FQ YKSG+Y EP+CS    +HGVLVVGYG    D     YWIVKNSW   WG  GYI+++KD+ N C IA+ AS+P++
Sbjct:    5 LGIAAICLTTVFAAPTTDPALDNHWNLWKNWHKKSYA-PKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 286.96 bits (733), Expect = 4.627e-94
Identity = 152/333 (45.65%), Postives = 213/333 (63.96%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQ-QLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +    L+    +   +  L++ W L+   + K+Y  P  E  RR++WE NL+ I  HNL+H LG ++ +LG+NQF D+T+ EF+ +      +    G+T+L P N F  P +VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ +R TG+++S SEQ LVDCS +  N GC+GGLM  AF  +KD GGI+SE  YPY A+    C ++ +    + +G+ ++   +E  L  AVA+ GP+SV +     +FQ YKSG+Y EP+CS    +HGVLVVGYG    D     YWIVKNSW   WG  GYI+++KD+ N C IA+ AS+P++
Sbjct:   12 LGIAAICLTTVFAAPTTDPALDNHWNLWKNWHKKSYA-PKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAP-NNFESPKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433])

HSP 1 Score: 283.878 bits (725), Expect = 6.008e-93
Identity = 144/317 (45.43%), Postives = 198/317 (62.46%), Query Frame = 1
Query:  202 NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLN--------AFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            N  L+ +W+++   Y+K Y+N  HEL+RR+IWE NL  I  HNL+   GL+T+ LG+N+F D+T  E   + +   L+ +    T + P N        +  +P ++D+ +KGYVT ++DQG+CGSCWAFST G+LEGQ  +KTG+LV  S Q LVDC   N+GC GG MT+AF  +K   GI+SE+ YPY      C +N S     + G+KE+ + +E +L  AV   GPISVGI   L+ F LYK G+Y +  C     NH VL VGYG      YWI+KNSWG  WG KGYI M+++K N C IA+ AS+PV+
Sbjct:   21 NGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEE--VVRMMTGLKVH----TGMGPTNLTSDEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKDNFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsk (cathepsin K [Source:MGI Symbol;Acc:MGI:107823])

HSP 1 Score: 288.886 bits (738), Expect = 4.357e-95
Identity = 145/320 (45.31%), Postives = 200/320 (62.50%), Query Frame = 1
Query:  169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
            LL   + +++    L+ QW+L+ K + K Y +   E+ RR+IWE NLK I  HNL+  LG++T+ L +N   D+T  E         + P+++   +T   P     VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ  +KTG+L++ S Q LVDC   NYGC GG MT+AF  ++  GGI+SE  YPY  Q  +C++N +       GY+EI   NE +L  AVA  GPISV I  SL +FQ Y  GVY + +C R   NH VLVVGYGT     +WI+KNSWG  WG KGY  ++++K+N C I + ASFP
Sbjct:    8 LLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452])

HSP 1 Score: 274.248 bits (700), Expect = 2.168e-89
Identity = 154/330 (46.67%), Postives = 199/330 (60.30%), Query Frame = 1
Query:  148 ILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTG-NTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSR-VPNHGVLVVGYG-TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +  +    L   + + A N  L+  W+ +   + KTY N   E  +R +WE+N K I  HN D+  G + F+L +N F DLT+ EF+ +      +  K     +  PL   +VP +VDW + GYVT VKDQG CGSCWAFS  GSLEGQ FRKTG+LV  S Q LVDCS S  N GC GGL   AF  +KD GG+++   YPY+A    C +N      +V+G+  +  +E +L  AVA  GPISVGI     +FQ YK G+Y EPDCS  V +H VLVVGYG  S    YW+VKNSWG  WGM GYI M+KD++N C IAS AS+PV+
Sbjct:    4 VFLLATLCLGVVSAAPAHNPSLDAVWEEWKTKHKKTY-NMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPLLG-DVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNVQSSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 274.248 bits (700), Expect = 2.714e-89
Identity = 142/308 (46.10%), Postives = 200/308 (64.94%), Query Frame = 1
Query:  220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +W  +   + + Y     E  RR IWE N++ I  HN ++  G + F++ +N F D+T+ EF+ +      + +K G  +  PL    +P +VDW EKG VT VK+QG+CGSCWAFS +G LEGQ F KTG+L+S SEQ LVDCS +  N GC+GGLM  AF  IK+ GG++SE+ YPY+A+  +C +     V + +G+ +I + E +L  AVA  GPISV +  S  + Q Y SG+Y EP+C S+  +HGVL+VGY   GT  N N YW+VKNSWG  WGM+GYI ++KD+DN C +A+ AS+PV+
Sbjct:   28 EWHQWKSTHRRLY-GTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 274.248 bits (700), Expect = 2.714e-89
Identity = 142/308 (46.10%), Postives = 200/308 (64.94%), Query Frame = 1
Query:  220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +W  +   + + Y     E  RR IWE N++ I  HN ++  G + F++ +N F D+T+ EF+ +      + +K G  +  PL    +P +VDW EKG VT VK+QG+CGSCWAFS +G LEGQ F KTG+L+S SEQ LVDCS +  N GC+GGLM  AF  IK+ GG++SE+ YPY+A+  +C +     V + +G+ +I + E +L  AVA  GPISV +  S  + Q Y SG+Y EP+C S+  +HGVL+VGY   GT  N N YW+VKNSWG  WGM+GYI ++KD+DN C +A+ AS+PV+
Sbjct:   28 EWHQWKSTHRRLY-GTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQQEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctss (cathepsin S [Source:MGI Symbol;Acc:MGI:107341])

HSP 1 Score: 274.248 bits (700), Expect = 2.910e-89
Identity = 149/334 (44.61%), Postives = 204/334 (61.08%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLR-PNKTGNTY-LPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS----ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +R L   P + S     +  +  L+  W L+ K + K Y++   E +RR+IWE NLK+I  HNL++ +G++T+ +G+N   D+T+ E   +   G LR P ++  T      +   +P  VDW EKG VT+VK QG CG+CWAFS  G+LEGQ   KTG+L+S S Q LVDCS      N GC GG MT AF  I D GGIE++  YPYKA    C +N      + S Y ++   +E +L  AVA +GP+SVGI  S  +F  YKSGVY++P C+   NHGVLVVGYGT    +YW+VKNSWG  +G +GYI M+++  N C IAS+ S+P I
Sbjct:    9 IRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEI--LCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI 340          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2)

HSP 1 Score: 298.901 bits (764), Expect = 4.460e-98
Identity = 153/331 (46.22%), Postives = 208/331 (62.84%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +  + L   + ++  +  L  QW  +  ++N+ Y     E  RR +WE N+K I  HN ++  G ++FT+ +N F D+T  EF+ +      R  + G  +  PL  +  P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTGRL+S SEQ LVDCS    N GC+GGLM  AF  ++D GG++SE+ YPY+A + +C +N    V + +G+ +I + E +L  AVA  GPISV I     +F  YK G+Y EPDCS    +HGVLVVGYG     S N+ YW+VKNSWG  WGM GY+ M+KD+ N C IAS AS+P +
Sbjct:    5 LILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1)

HSP 1 Score: 297.36 bits (760), Expect = 1.769e-97
Identity = 154/324 (47.53%), Postives = 203/324 (62.65%), Query Frame = 1
Query:  172 LSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYG----TSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L   + ++  N  L  QW  +  ++N+ Y     E  RR +WE N+K I  HN ++  G ++FT+ +N F D+T  EF+ +      R  + G  +  PL  +  P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS    N GC+GGLM  AF  + D GG++SE+ YPY+A + +C +N    V + +G+ +I + E +L  AVA  GPISV I     +F  YK G+Y EPDCS    +HGVLVVGYG     S N  YW+VKNSWG  WGM GYI M+KD+ N C IAS AS+P +
Sbjct:   12 LGIASATLTFNHSLEAQWTKWKAMHNRLY-GMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GL24|CATL1_CANLF (Cathepsin L1 OS=Canis lupus familiaris OX=9615 GN=CTSL PE=2 SV=1)

HSP 1 Score: 290.426 bits (742), Expect = 8.375e-95
Identity = 152/331 (45.92%), Postives = 209/331 (63.14%), Query Frame = 1
Query:  151 LTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGY---GTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L +T   L   + +   +  LN QW  +   + + Y     E  RR +WE N+K I  HN ++  G + FT+ +N F D+T+ EF+ +      + +K G  +  PL A  +P +VDW EKGYVT VK+QG+CGSCWAFS TG+LEGQ FRKTG+LVS SEQ LVDCS +  N GC+GGLM +AF  +KD GG++SE+ YPY  +    C +       + +G+ ++ + E +L  AVA  GPISV I     +FQ YKSG+Y +PDC S+  +HGVLVVGY   GT  N+ +WIVKNSWGP WG  GY+ M+KD++N C IA+ AS+P +
Sbjct:    5 LFLTALCLGIASAAPKFDQSLNAQWYQWKATHRRLY-GMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKMFQEPLFA-EIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O35186|CATK_RAT (Cathepsin K OS=Rattus norvegicus OX=10116 GN=Ctsk PE=2 SV=1)

HSP 1 Score: 288.886 bits (738), Expect = 2.764e-94
Identity = 145/320 (45.31%), Postives = 201/320 (62.81%), Query Frame = 1
Query:  169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
            LL   + +++    L+ QW+L+ K + K Y +   E+ RR+IWE NLK I  HNL+  LG +T+ L +N   D+T  E         + P+++   +T   P     VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ  +KTG+L++ S Q LVDC   NYGC GG MT+AF  ++  GGI+SE  YPY  Q  +C++N +       GY+EI   NE +L  AVA  GP+SV I  SL +FQ Y  GVY + +C R   NH VLVVGYGT   + YWI+KNSWG  WG KGY+ ++++K+N C I + ASFP
Sbjct:    8 LLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P55097|CATK_MOUSE (Cathepsin K OS=Mus musculus OX=10090 GN=Ctsk PE=1 SV=2)

HSP 1 Score: 288.886 bits (738), Expect = 3.047e-94
Identity = 145/320 (45.31%), Postives = 200/320 (62.50%), Query Frame = 1
Query:  169 LLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRV-PNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFP 1113
            LL   + +++    L+ QW+L+ K + K Y +   E+ RR+IWE NLK I  HNL+  LG++T+ L +N   D+T  E         + P+++   +T   P     VP ++D+ +KGYVT VK+QG+CGSCWAFS+ G+LEGQ  +KTG+L++ S Q LVDC   NYGC GG MT+AF  ++  GGI+SE  YPY  Q  +C++N +       GY+EI   NE +L  AVA  GPISV I  SL +FQ Y  GVY + +C R   NH VLVVGYGT     +WI+KNSWG  WG KGY  ++++K+N C I + ASFP
Sbjct:    8 LLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 347.436 bits (890), Expect = 1.407e-114
Identity = 179/337 (53.12%), Postives = 244/337 (72.40%), Query Frame = 1
Query:  142 MRILTVTP-YLLSFFAI--SIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP---NKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M+I+ +T  +L++  A+     +N ELND+W++Y   ++K YE   +E+ RR+IWE+NLK+I +HN+++DLG +T+ LG+N+FAD+TH EFKA YL   L+P   N T + ++ P N  ++P  +DW  KGYVT VK+QG+CGSCWAFSTTGSLEGQ FRK+G+LVSFSEQQLVDCS S  N GC+GGLM +AF+ I+   GIE+E  YPY A    C ++++K+V + +G+ +I   NE  L  AVA +GPISV I  S + FQ Y+ G+YNEP C S+  +HGVL +GYG+  N+NYWIVKNSW   WGM GYI MSKDK NQC IA+ AS+P++
Sbjct:    1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYET-LNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLG--LKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKF-GIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1)

HSP 1 Score: 340.117 bits (871), Expect = 8.831e-112
Identity = 175/312 (56.09%), Postives = 215/312 (68.91%), Query Frame = 1
Query:  199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
              LELN++W+ Y   + K YE    EL+RR+IWE NL++I KHNL++D G++++TLG+NQF DLT  EFKA YLS        G+ +LP  N  ++P  VDW  KGYVT VKDQ +CGSCWAFSTTGSLEGQ F+KTG LVS SEQ LVDCS    N GC+GGLM + F  IK   GI++E  YPYKA+   C F  S V  +VSG+ +I  +NE +L  AVA  GPISV I     +FQLYKSGVY+E  CS    +HGVL VGYGT     YW+VKNSWG  WGMKGYI MS++K NQC IAS AS+P++
Sbjct:   21 FTLELNEEWEAYKSTHGKVYEAD-EELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 339.732 bits (870), Expect = 1.238e-111
Identity = 175/312 (56.09%), Postives = 215/312 (68.91%), Query Frame = 1
Query:  199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEID-ENEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
              LELN++W+ Y   + K YE    EL+RR+IWE NL++I KHNL++D G++++TLG+NQF DLT  EFKA YLS        G+ +LP  N  ++P  VDW  KGYVT VKDQ +CGSCWAFSTTGSLEGQ F+KTG LVS SEQ LVDCS    N GC+GGLM + F  IK   GI++E  YPYKA+   C F  S V  +VSG+ +I  +NE +L  AVA  GPISV I     +FQLYKSGVY+E  CS    +HGVL VGYGT     YW+VKNSWG  WGMKGYI MS++K NQC IAS AS+P++
Sbjct:   21 FTLELNEEWEAYKSTHGKVYEAD-EELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1Z5KUE4 (Uncharacterized protein (Fragment) OS=Ornithodoros moubata OX=6938 PE=3 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 3.477e-111
Identity = 171/334 (51.20%), Postives = 229/334 (68.56%), Query Frame = 1
Query:  136 FQMRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNA---FNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
              +R+L V+  +    A ++    +LN  W++Y +++ K Y  P  E  RR+IWEDNL +I KHNL++DLGL+T+ +G+N FADLT  E++  +L    R N+T    L    A   +++P +VDW E+GYVT VK+QG+CGSCWAFS TGSLEGQ FRKTG+LVS SEQ LVDC  ++ GC+GG M SAF  ++  GGI++E  YPY A    C FN S V  +  GY +++  +E  L  AVA  GP+SV I  S N FQ Y+SGVYNEPDC S+  +HGVLVVGYGT  +++YWIVKNSWG  WG +GYI MS+++DNQC IAS AS+P++
Sbjct:    1 MSLRLLVVSAIVACALARTVP-RPQLNAHWEVYKEVHQKKY-GPGEENRRRLIWEDNLDFIQKHNLEYDLGLHTYRVGVNSFADLTSKEYRETFL--GYRHNRTRKVPLATHQAISLYDLPEHVDWREEGYVTPVKNQGQCGSCWAFSATGSLEGQHFRKTGKLVSLSEQNLVDCDQTSDGCNGGSMDSAFQYVQSNGGIDTESSYPYVAHDEACEFNPSTVGATDKGYHDVESGSEDDLQSAVATVGPVSVAIDASQNSFQFYQSGVYNEPDCSSKSLDHGVLVVGYGTLNDEDYWIVKNSWGEAWGDEGYILMSRNRDNQCGIASDASYPLV 330          
BLAST of Cathepsin L2 vs. TrEMBL
Match: W4YG82 (Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=3 SV=1)

HSP 1 Score: 332.413 bits (851), Expect = 8.298e-109
Identity = 172/334 (51.50%), Postives = 225/334 (67.37%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIY----LSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDC-SRVPNHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            + +L V   ++S  ++S     + ++ W  +   + K Y +   E  RR+IW+ NL  + KHNL +DLG +T+ LGINQFADL + EF A+     +SG  +  K G+T+LPP N   +P  VDW  KGYVT VKDQG+CGSCWAFSTTGS+EGQ F+ TG+LVS SEQ LVDCS  + GC GG M  AF  I D GGI++E  YPYKA    C F ++ V  +V+GY ++   +E +L  AVA+ GPISV I  S ++FQ YKSGVYNEP C S V +HGVL VGYGTS +  +YWIVKNSW   WGM GY+WMS++KDNQC IA+ AS+P++
Sbjct:    4 LSVLLVAACVVSSLSMSFT---DFDEDWNEWKNEHGKRYLSDEEEASRRLIWQKNLDIVIKHNLKYDLGHFTYDLGINQFADLQNEEFVAMMTGFRVSGTSKAAK-GSTFLPPNNVGELPKTVDWRTKGYVTPVKDQGQCGSCWAFSTTGSVEGQHFKATGKLVSLSEQNLVDCSGRDAGCDGGFMDRAFQYIIDAGGIDTEASYPYKAVDGKCHFKKANVGATVTGYTDVTSGSEKALQKAVAHVGPISVAIDASHMSFQHYKSGVYNEPGCDSTVLDHGVLAVGYGTSSDGTDYWIVKNSWAETWGMNGYVWMSRNKDNQCGIATNASYPLV 333          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700])

HSP 1 Score: 293.893 bits (751), Expect = 4.915e-97
Identity = 162/339 (47.79%), Postives = 214/339 (63.13%), Query Frame = 1
Query:  148 ILTVTPYLLSFFAISI---ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
             LT+   L   F       +L+ +L+D WKL+   ++K+Y     E  RR++WE NLK +  HNL+H +G +T+ LG+NQFAD+T+ EF+         PNK   G+ +L P +   VP  VDW EKGYVT VKDQ +CGSCWAFS+TG+LEGQ FRKTG+LVS SEQ LVDCS    N GC+GG+M  AF  +KD GGI+SE+ YPY A+    C ++ +    + +G+ +I    E +L  AVA  GP+SV I     +FQ Y+SG+Y E  CS    +HGVLVVGYG    D     YWIVKNSW   WG  GYI+M+KD+ N C IAS AS+P++
Sbjct:    2 FLTLASLLALCFCTGFTAPSLDRQLDDHWKLWKSWHSKSYHEK-EEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEP-SFLEVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000047972.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000030.1:138766:150097:-1 gene:ENSAMXG00000038942.1 transcript:ENSAMXT00000047972.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 287.345 bits (734), Expect = 1.370e-94
Identity = 148/308 (48.05%), Postives = 196/308 (63.64%), Query Frame = 1
Query:  220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS--GNLRPNKTGNT--YLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +WKL    + K+Y +   E  R+MIW  NLK + +HN+  D GL +  LG+N FAD+ + EF+ +     G+    K  N   +        VP  VDW  +GYVT+VK QG CGSCWAFS+TG+LEGQ F+KTG LVS SEQQLVDCS S  N GC+GGLM+ AFN + + GG+++E  YPY+ Q   C FN+  V  + SGY  I   +E  L   V   GP+SV +   ++FQLY+SG+Y+E DCS    NHGVL VGYG+    +YW+VKNSW   WG  GYI MS++K+NQC IA+FA +P +
Sbjct:   26 EWKLK---FGKSYSSEAEESQRKMIWMTNLKLVLEHNMLADQGLKSHRLGMNHFADMENQEFRKMLSRCLGSFDTTKIHNATKFTGKAGGAAVPDTVDWRTQGYVTEVKSQGLCGSCWAFSSTGALEGQMFKKTGSLVSLSEQQLVDCSESYGNNGCNGGLMSYAFNYVMNNGGLDTEASYPYEGQDSVCRFNQYSVGATCSGYTFISSGSEEELKEVVGTVGPVSVAVDAEVSFQLYQSGIYDESDCSSTQLNHGVLAVGYGSQNGKDYWLVKNSWSTSWGEAGYIRMSRNKNNQCGIATFALYPEV 330          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000001927.2 (cathepsin L1-like [Source:NCBI gene;Acc:107197646])

HSP 1 Score: 286.574 bits (732), Expect = 3.548e-94
Identity = 162/339 (47.79%), Postives = 214/339 (63.13%), Query Frame = 1
Query:  142 MRIL-TVTPYLLSFFAISIAL-NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN-----KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGI-SVSLNFQLYKSGVYNEPDCSRV-PNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            MR+L TVT  +    A S++L +LE   +WKL    Y K+Y++   E  R+MIW  NLK + +HN+  D GL T+ LG+N FAD+   E++ ++  G LRP+     ++   +L       +P ++DW + GYV++VK QG C SCWAFS  G+LEGQ FRKTG LVS S QQLVDCS    N GC GG M  AF  I   GG+E+E +YPYKA++  C+FN   V      ++E+ +  E  L  AV   GP+SV I S +  F LY+SG+YNEP CS    NHGVLVVGY T S    YW+VKNSWG  WG +GYI MS++KDNQC IA+ ASFP++
Sbjct:    1 MRVLLTVTTLVAVVSATSVSLEDLEFQ-EWKLK---YGKSYDSEEEESQRKMIWMTNLKLVLEHNMLADQGLKTYRLGMNHFADMDDQEYQQMF-RGYLRPSNRTKPRSAGRFLQQAENVALPYSIDWRDNGYVSNVKTQGHCASCWAFSAAGALEGQMFRKTGSLVSLSMQQLVDCSWLDGNDGCGGGSMELAFEYISRSGGLETESDYPYKAREGMCMFNPQDVSGKCHDFEELPKGEEKDLQKAVVAVGPVSVAIDSSNKTFLLYQSGIYNEPYCSSYNVNHGVLVVGYNTDSSGREYWVVKNSWGVQWGEQGYIRMSRNKDNQCGIATRASFPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607])

HSP 1 Score: 280.796 bits (717), Expect = 6.299e-92
Identity = 150/308 (48.70%), Postives = 197/308 (63.96%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS--GNLRPNK--TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            WKL    + K Y +   E  R++ W  N K +  HN+  D G+ ++ LG+  FAD+ + E++ ++ S  G+    K  +  T+L       +P  VDW  KGYVTD+KDQ  CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS    N+GC GGLM  AF  IK   GI++E  YPY+A   +C F    V  + +G+ +I   +E +L  AVA  GPISV I     +FQLY+SG+YNEPDCS    +HGVL VGYGT    +YW+VKNSWG  WG KGYI MS+++DNQC IA+ +S+P++
Sbjct:   29 WKLK---FGKIYHSVEEESQRKLTWLTNRKLVLVHNMLADQGIKSYRLGMTFFADMDNKEYRKLFASCLGSFNRTKAHSATTFLRQTLRDPLPDTVDWRPKGYVTDIKDQKDCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNFGCGGGLMDQAFEYIKANKGIDTEDSYPYEAVDGDCRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGTDNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYPLV 333          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103027561])

HSP 1 Score: 279.641 bits (714), Expect = 1.977e-91
Identity = 154/306 (50.33%), Postives = 196/306 (64.05%), Query Frame = 1
Query:  244 YNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTG------NTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDN---YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            + K+Y++   E  R+MIW +N K + +HN+  D GL ++ LG+N FAD+ + EF+A++ +     N T       +T++P      +P  VDW  KGYVTDVK+Q  CGSCWAFS TGSLEGQ FRKT RL+S SEQQLVDCS    N+GC+GGL   AFN I+   G+E++  YPYKAQ   C FN  KV  +  G   +   NE +L IAVA  GPISV I  S + FQLYKSGVY+EP CS    NH VL+VGYG   N N   YW+VKNSWG  WG  GYI MS++K NQC IA    +P++
Sbjct:   33 HGKSYDSEEEESERKMIWLNNRKLVLEHNMLADQGLKSYRLGMNIFADMENQEFQAMFSNCVESLNDTDTDSLCTSTFVPEKEGSALPCRVDWRRKGYVTDVKNQRNCGSCWAFSATGSLEGQMFRKTRRLISLSEQQLVDCSRCFGNHGCNGGLAIWAFNYIRSSKGLEADFTYPYKAQDRRCHFNPWKVRATCRGTVCLPRGNEIALKIAVARVGPISVSIDASKHTFQLYKSGVYDEPRCSNNRLNHAVLLVGYGRIRNRNRKQYWLVKNSWGTRWGENGYIRMSRNKMNQCGIAKRPVYPLV 338          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 299.286 bits (765), Expect = 2.539e-100
Identity = 159/299 (53.18%), Postives = 200/299 (66.89%), Query Frame = 1
Query:  250 KTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYL----SGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDN-YWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            KTY+    E  RRMIWE NLK I  HNL+H +G +T+ +G+N+F D+T  EF+   L    S +      G T++ P   F  P +VDW ++GYVTDVKDQG CGSCWAFSTTGSLEGQ  RKTG LVS SEQ LVDCS +  N GC GGLM  AF  IK  GGI+SE  YPY A+  NC +N        +G+ +I   NE +L  AVA+ GP+S+GI  SL +FQLY SG+Y++ DCS   +HGVLVVGYG   ++  +WIVKNSWG  WG  GYI M++DKDN C IA+ AS+P++
Sbjct:    1 KTYDQN-EEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLRGSNDTSKASRGATFMAPA-FFKAPESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSNNLDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 290.426 bits (742), Expect = 5.720e-97
Identity = 153/289 (52.94%), Postives = 194/289 (67.13%), Query Frame = 1
Query:  283 RRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLS----GNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQL-NCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVPNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            RRMIWE NLK I  HNL+H +G +T+ +G+N+F D+T  EF+ + L             G T++ P   F  P +VDW ++GYVTDVK+QG CGSCW+FSTTGSLEGQ  RKTG LVS SEQ LVDCS +  NYGC+GGLM +AFN IK  GGI+SE+ YPYK Q +  C +N       V+GY EI E +E +L  AVA+ GP+SV I  SLN F  Y SG+Y +  CS + NH VLVVGYG     D +W+VKNSWG  WG KGY+ M++D +N C IA  AS+P++
Sbjct:    8 RRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPA-FFEAPESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLCSHIINHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYPLV 295          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 290.041 bits (741), Expect = 3.415e-96
Identity = 164/342 (47.95%), Postives = 224/342 (65.50%), Query Frame = 1
Query:  142 MRIL-TVTPYLLSFFAISIAL-NLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSG--NLRPNKT--GNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLN-CVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGY---GTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M +L ++ P LL+  A +  + +  L+++W  +   + K YE P  E  RRMIWE NL  I  HNL+H LG +T+ +G+N F D+T+ EF+   ++G   ++P+K   G+T+L P N +  P  VDW +KG VT+VKDQG+CGSCWAFSTTG+LEGQ  RK G+LVS SEQ LVDCS +  N GC GGLM  AF  +KD GGI+SE  YPY     + C ++      + +G+ ++   +E +L IAVA+ GP+SV I  S  +FQ Y+SGVY EPDCS    +HGVLVVGY   GT  N   YWIVKNSW P WG +GY+ M+++K N C IA+ AS+P++
Sbjct:    1 MNVLWSLVPALLAVMASATPIHDPMLDEEWGSWKGFHQKLYE-PKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQ-KMNGYHGVQPHKVSKGSTFLVPQN-YEAPPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 287.345 bits (734), Expect = 9.611e-96
Identity = 147/289 (50.87%), Postives = 199/289 (68.86%), Query Frame = 1
Query:  283 RRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYL-----SGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGT-SVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            RR+IWE NLK I  HNL+H +G +T+ +G+NQF+D+T  EF+ + L     +G  +  + G T++ P   F  P +VDW ++GYVTD+K+QG CGSCW+FSTTGSLEGQ  RKTG LVS SEQ LVDCS +  N+GC+GGLM +AFN IK  GGI+SE+ YPYK Q   C ++       V+GY EI E +E +L  AVA+ GP+SV I  SL +FQ Y SG+Y +  CS   +H VLVVGYG   +   +W+VKNSWG  WG +GY+ M++D +N C IA+ +S+P++
Sbjct:    7 RRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPR-GATFMAPA-FFEAPESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMCSHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007755.1 (pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 gene:ENSPMAG00000007008.1 transcript:ENSPMAT00000007755.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 268.855 bits (686), Expect = 6.412e-88
Identity = 150/309 (48.54%), Postives = 192/309 (62.14%), Query Frame = 1
Query:  220 QWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEF--KAIYLSGNLRPNKTGNTYLP-PLNAF-NVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNY--GCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYK--EIDENEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            QW  +   Y K Y +   +  RR ++E NLK + +HNL  D G  +F LGIN+++DL   E+  K +    NLR N T     P PL +  N+P  VDW  KGYVT VK+QG CGS WAFS TGSLEGQ F  TG L S SEQQLVDC+ S Y  GC+GG    A   I D  GI+SE  YPY+     C F  + V T  S Y+  E   NE  L  AVA+ GPI++ ++  L+ F+ YKSG++NEP C + PNH +LVVGYG+   +++WIVKNSWG  WG KGYI+M ++KDNQC IAS   +P+I
Sbjct:   26 QWDTWKSTYGKHYGSEQEDAHRRDVFEQNLKRVLQHNLLADEGNVSFHLGINKYSDLELHEYHEKVVGRFWNLR-NGTRRRGAPFPLRSMDNLPEQVDWRLKGYVTPVKEQGLCGSSWAFSATGSLEGQHFAATGNLTSLSEQQLVDCTKSYYNNGCNGGRSERALQYIIDNNGIDSELSYPYEHADGKCRFKPANVATKCSSYQFVEPSSNEEVLRQAVASVGPIAIAMNADLDTFKHYKSGLFNEPSCDKSPNHAMLVVGYGSLSGNDFWIVKNSWGEDWGEKGYIYMIRNKDNQCGIASIGIYPII 333          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5])

HSP 1 Score: 311.227 bits (796), Expect = 2.381e-104
Identity = 160/310 (51.61%), Postives = 204/310 (65.81%), Query Frame = 1
Query:  205 LELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L  + QW  +   + KTY     E +RR IW DNL+ + KHN ++    +++ L +N FADLT  EFK  ++      N TG +   PL+   +PA VDW +KG+VT VK+QG+CGSCWAFS+TGSLEGQ FRKTG+LVS SEQ LVDCS    N GC GGLM  AF  IK+  GI++EQ YPY A+   C F    V  +V+GY ++   +EG L  AVA  GPISV I     +FQLYK+GVY+EPDCS    +HGVL VGYG     +YW+VKNSWG  WGM GYI MS++KDNQC IA+ AS+P++
Sbjct:   21 LSQDRQWHAWKDFHGKTYTGE-EEDLRRAIWNDNLEIVKKHNAEN----HSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFLPLSNVQLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1])

HSP 1 Score: 293.123 bits (749), Expect = 3.339e-97
Identity = 155/337 (45.99%), Postives = 209/337 (62.02%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN------KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M++L     L +  +  +    E   QW+ +   + K Y     E  R+ IW DNLK I KHN +     ++FTL +N   DLT  EF+  Y    +R +      K G+ +L P +   VP  VDW ++GYVT VK+QG+CGSCWAFSTTGSLEGQ F+KTG+LVS SEQ LVDCS +  N GC GGLM  AF  IK+ GGI++E+ YPY+A+   C F +S +    +G+ ++   +E +L  A    GPISV I    ++FQ Y SGVYN   CS    +HGVLVVGYGT    +YW+VKNSWG  WGM+GYI MS++K+NQC +A+ AS+P++
Sbjct:    1 MKLLVAACLLFAVASGFVVKFDEDEQQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAEG----HSFTLAMNHLGDLTQDEFRYFYTG--MRSHYSNYTKKQGSAFLAPSHV-QVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6])

HSP 1 Score: 292.738 bits (748), Expect = 3.684e-97
Identity = 150/315 (47.62%), Postives = 206/315 (65.40%), Query Frame = 1
Query:  196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGN---TYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSIS--NYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            ++    + +W  +   + K+Y +   E  R  IW+ NL+ I +HN +     +++ + +N   DLT  EF+  YL      N T     TY+PP N   +P++VDW++KGYVT VK+QG+CGSCWAFSTTGS+EGQ FRKTG LVS SEQ L+DCS S  N GC GGLM +AF  I+  GGI++E  YPY  QQ +C F+ S V   V+GY++I + +E +L  AVA  GP+SV +  S  +Q Y SGVY+ P CS    +HGVLV+GYG     +YW+VKNSWG  WG++GYI MS++K+NQC IAS AS+P++
Sbjct:   18 SVRFGQDSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAED----HSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSNV-KIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDAS-QWQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9])

HSP 1 Score: 277.715 bits (709), Expect = 3.235e-91
Identity = 145/308 (47.08%), Postives = 197/308 (63.96%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNK----TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            WK +   + K Y N   E +R  IW++NLK I  HN     G ++F L +N   D+T  E     L   L+ +      G T+LPP N   V  ++DW  KGYVT VK+QG+CGSCWAFSTTG+LEGQ FRKTG+LVS SEQ LVDCS    N GC GGLM +AF  IK+ GGI++E+ YPY A+   C +N+S +    +G+ +I   +E +L  A+A+ GPIS+ I  S + F  Y  GVY++PDCS    +HGVL VGYGT    +YW+VKNSWGP WG +GYI ++++  ++C +AS AS+P++
Sbjct:   29 WKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHNE----GKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPAN-VKVVDSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO42751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0K3])

HSP 1 Score: 206.068 bits (523), Expect = 3.948e-64
Identity = 114/259 (44.02%), Postives = 157/259 (60.62%), Query Frame = 1
Query:  292 IWEDNLKYIHK-HNLDHDLGLYTFTLGINQFADLTHAEF-KAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVP---NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGY 1053
            I+E N++   K   +D     Y  T+    F+DL+  EF K   + G  +P         PL   ++P +VDW +KG VT VK+QG CGSCWAFSTTG++EGQ+  KTG+LVS SEQ+LVDC   + GC GGL ++A+  I+ LGG+ESE +YPYK     C FN+++V  +++    I ++E  +A  +A  GPIS+GI+ +   Q Y  G+ +       P   NHGVL+VGYG      YWI+KNSWGP WG KGY
Sbjct:    3 IFESNMRKAAKMQKMDSGTAQYGPTI----FSDLSEEEFRKQKMMPGWGKPLYEMKDAEIPLG--DIPESVDWRDKGVVTPVKNQGSCGSCWAFSTTGNIEGQYAIKTGKLVSLSEQELVDCDTIDKGCEGGLPSNAYKQIEKLGGLESESDYPYKGADSKCKFNKAEVKVTINSSVVISKDEKEIAAWLAKNGPISIGINANA-MQFYMGGIAHPWKIFCNPSSLNHGVLIVGYGVKNGTPYWIIKNSWGPSWGEKGY 254          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789])

HSP 1 Score: 295.434 bits (755), Expect = 1.287e-97
Identity = 152/309 (49.19%), Postives = 203/309 (65.70%), Query Frame = 1
Query:  223 WKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSG-----NLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVS-LNFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            W+L    + +TY +P  E  RR  W +N K +  HN+  D G+ ++ LG+  FAD+ + E+K +   G     N    + G+T+       ++PA VDW +KGYVTDVKDQ +CGSCWAFS TGSLEGQ FRKTG+LVS SEQQLVDCS    N GC GGLM  AF  I+  GGI++E+ YPY+A+   C +    V  + +GY ++   +E +L  AVA  GPISVGI  S ++FQLY+SG+Y+EP CS    +HGVL VGYG+    +YW+VKNSWG  WG +GYI MSK+K NQC IA+ AS+P++
Sbjct:   34 WRLK---FGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENKDLPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246])

HSP 1 Score: 283.878 bits (725), Expect = 3.903e-93
Identity = 152/319 (47.65%), Postives = 204/319 (63.95%), Query Frame = 1
Query:  199 LNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNK--TGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKA-QQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVND----NYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            L+ +L+  W+L+   ++K Y     E  RR++WE NL+ I  HNL+H +G +++ LG+N F D+TH EF+ I      R  +  +G+ ++ P N    P  VDW +KGYVT VKDQG+CGSCWAFSTTG+LEGQ FRKTG+LVS SEQ LVDCS    N GC+GGLM  AF  +KD  G++SE  YPYK      C +N      + +G+ +I    E +L  AVA+ GP+SV I     +FQ Y+SG+Y E +CS    +HGVLVVGYG    D     YWIVKNSW   WG KG+I+M+KD+ N C IA+ AS+P++
Sbjct:   20 LDPQLDQHWQLWKGWHSKNYHEK-EEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEP-NFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsk (cathepsin K [Source:NCBI gene;Acc:101164922])

HSP 1 Score: 269.626 bits (688), Expect = 1.269e-87
Identity = 143/330 (43.33%), Postives = 197/330 (59.70%), Query Frame = 1
Query:  154 TVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAE----FKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSLN-FQLYKSGVYNEPDCSRVP-NHGVLVVGYGTSVN-DNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            T    LLS   +S      L+  W+ +   + K Y     E IRR IWE NL+ I  HN +  LG++T+TLG+NQF D+T  E       + +  N  P     T     +   +P +VD+ +KG VT VK+QG CGSCWAFS+ G+LEGQ  +KTG LV  S Q LVDC   N GC GG MT+AF  +++ GGI+SE  YPY  +   C +N S +   + GYKE+ E +E +LA+A+   GP+SVGI  S N F  Y+ G+Y + +C++   NH VL VGYG +     +WIVKNSWG  WG KGY+ M++++ N C IA+ AS+PV+
Sbjct:    5 TCVLLLLSASVMSQMDETTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGLQMPLNPEPRVPMET---DGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTENDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247])

HSP 1 Score: 264.618 bits (675), Expect = 1.074e-85
Identity = 142/314 (45.22%), Postives = 190/314 (60.51%), Query Frame = 1
Query:  196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTY--LPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSI--SNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            A+   L+  W L+ K Y+KTY +   E  RR IWE+NL+ I  HNL+  LGL+++ L +N   DLT  E  A  L+G + P      +  L  +N  +VP +VDW E G VT VK QG+CGSCWAFS  G+LEGQ  + TG L S S Q LVDCS    NYGC GG M++AF  +    GI S+  YPY  ++  C ++      + +GY  + + +E +L + VA  GPISV I  S   F  Y+ GVY +  CS   NHGVLVVGYGT   ++YW+VKNSWG  +G  GYI M++++ NQC IA +A FPV+
Sbjct:   16 AVRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIA-SLTGTVAPVGLERIHYDLVKINT-SVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSCSHNVNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175])

HSP 1 Score: 259.225 bits (661), Expect = 1.574e-83
Identity = 135/316 (42.72%), Postives = 192/316 (60.76%), Query Frame = 1
Query:  196 ALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP----NKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS--ISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDE-NEGSLAIAVANEGPISVGISVSL-NFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            A +  L+  W+L+ K ++K Y +   ++ RR +WE NL  I  HNL++ +GL+T+ L +N   DLT  E    + S  LRP     +  + ++    + N+P  +DW +K  VT VK QG CGSCWAFS  G+LEGQ  RKTG+LV  S Q LVDCS    N+GC+GG M  AF  + D  GI+S+  YPY     NC ++      + S Y  + E +EG+L  A+A  GPISV I  +   F  Y+SGVY++  CS+  NHGVL VGYGT    +YW+VKNSWG  +G +GYI M+++K++QC IA +  +P++
Sbjct:   26 AFDSRLDIHWELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEILQQFAS--LRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSCSQNVNHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYPIM 339          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049781.1 (SMESG000049781.1)

HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0
Identity = 318/326 (97.55%), Postives = 320/326 (98.16%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNL+P KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFS TGSLEGQFFRKTGRLVSFSEQQLVDCS SN GCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNC FN SKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPV+
Sbjct:    1 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLKPTKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSATGSLEGQFFRKTGRLVSFSEQQLVDCSKSNNGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCEFNHSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVV 326          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049783.1 (SMESG000049783.1)

HSP 1 Score: 650.973 bits (1678), Expect = 0.000e+0
Identity = 312/326 (95.71%), Postives = 317/326 (97.24%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISVSLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRP KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQG CGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCS SN GC+GGLMTSAFNDIKDLGGIESEQEYPY+AQQLNCVFNRSKVVTSVSGYKEI +NEGSLAIAVANEGPISV I VSLNFQLYKSGVYNEPDCSRVPNH VLVVGYGTSVNDNYWIVKNSWGP WGMKGYIWMSKDKDNQCAIASFASFP++
Sbjct:    1 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPTKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGNCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSKSNNGCNGGLMTSAFNDIKDLGGIESEQEYPYQAQQLNCVFNRSKVVTSVSGYKEIYKNEGSLAIAVANEGPISVLIRVSLNFQLYKSGVYNEPDCSRVPNHAVLVVGYGTSVNDNYWIVKNSWGPSWGMKGYIWMSKDKDNQCAIASFASFPIV 326          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1)

HSP 1 Score: 480.33 bits (1235), Expect = 3.656e-170
Identity = 227/331 (68.58%), Postives = 263/331 (79.46%), Query Frame = 1
Query:  130 VKFQMRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            +  QM     T +L+ FF    +LNLELNDQW+L+MKIYNK+YEN  HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN   +KTGNTYLPPLN+  +P  VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS  N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I   S +FQ YKSGVYNEP+C     H VLVVGYGT   DNYWIVKNSW   WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct:   27 LSLQMNTYLATSFLICFFGKCFSLNLELNDQWRLFMKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 357          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1)

HSP 1 Score: 477.248 bits (1227), Expect = 2.121e-169
Identity = 226/327 (69.11%), Postives = 261/327 (79.82%), Query Frame = 1
Query:  142 MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            M     T +L+ FF    +LNLELNDQW+L+MKIYNK+YEN  HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN   +KTGNTYLPPLN+  +P  VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS  N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I   S +FQ YKSGVYNEP+C     H VLVVGYGT   DNYWIVKNSW   WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct:    1 MNTYLATSFLICFFGKCFSLNLELNDQWRLFMKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 327          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049555.1 (SMESG000049555.1)

HSP 1 Score: 444.506 bits (1142), Expect = 5.910e-157
Identity = 211/296 (71.28%), Postives = 241/296 (81.42%), Query Frame = 1
Query:  235 MKIYNKTYENPFHELIRRMIWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPNKTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEGQFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQEYPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV-SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWGMKGYIWMSKDKDNQCAIASFASFPVI 1119
            MKIYNK+YEN  HE+IRR IWEDNLKYI KHNLDHDL LYTFTLGINQFADLTH EFKAIYL GN   +KTGNTYLPPLN+  +P  VDW EKGYVT+VK+QG CGSC++FS TGSLEGQ+FRK+ +LVS SEQQL+DCS  N GC+GG M +AF D+K +GGI+SE +YPYK ++L C F RSK +TS +GYK ID+NE SLAIAVANEGPISV I   S +FQ YKSGVYNEP+C     H VLVVGYGT   DNYWIVKNSW   WG+KGYIWMSKDK+NQC IAS+ASFP +
Sbjct:    1 MKIYNKSYENSLHEIIRREIWEDNLKYIQKHNLDHDLDLYTFTLGINQFADLTHEEFKAIYLPGNFTNSKTGNTYLPPLNSNELPKRVDWREKGYVTNVKNQGGCGSCYSFSATGSLEGQYFRKSKKLVSLSEQQLIDCSEKNSGCNGGWMNNAFQDVKIMGGIDSELDYPYKGKKLQCNFQRSKAITSCNGYKNIDKNENSLAIAVANEGPISVAIDASSRSFQFYKSGVYNEPNCGVNATHAVLVVGYGTDGFDNYWIVKNSWSTAWGIKGYIWMSKDKNNQCIIASYASFPEV 296          
The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTSL9.287e-9946.22cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSL9.287e-9946.22cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSK1.837e-9246.58cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536][more]
CTSS9.259e-9144.88cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545][more]
CTSV3.296e-8843.67cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
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BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpl-11.936e-8645.66CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-11.729e-6452.28CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-11.729e-6452.28CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
tag-1965.035e-5937.25pep chromosome:WBcel235:V:8594914:8597500:1 gene:W... [more]
tag-1965.035e-5937.25pep chromosome:WBcel235:V:8594914:8597469:1 gene:W... [more]
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BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cp11.706e-8946.84gene:FBgn0013770 transcript:FBtr0087592[more]
Cp12.775e-8946.84gene:FBgn0013770 transcript:FBtr0087593[more]
Cp14.689e-8847.88gene:FBgn0013770 transcript:FBtr0339955[more]
Cp11.116e-7653.91gene:FBgn0013770 transcript:FBtr0304021[more]
CG121633.219e-6339.67gene:FBgn0260462 transcript:FBtr0078822[more]
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BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.17.288e-10151.78cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.17.288e-10151.78cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.17.288e-10151.78cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
si:dkey-239j18.23.314e-9846.88si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
si:dkey-239j18.23.314e-9846.88si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-... [more]
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BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsk6.491e-9946.06cathepsin K (pycnodysostosis) [Source:NCBI gene;Ac... [more]
ctsk7.631e-9946.06cathepsin K (pycnodysostosis) [Source:NCBI gene;Ac... [more]
fcrl22.885e-9445.65Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
fcrl24.627e-9445.65Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
harbi16.008e-9345.43harbinger transposase derived 1 [Source:Xenbase;Ac... [more]
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BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ctsk4.357e-9545.31cathepsin K [Source:MGI Symbol;Acc:MGI:107823][more]
Ctsll32.168e-8946.67cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917... [more]
Ctsl2.714e-8946.10cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsl2.714e-8946.10cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctss2.910e-8944.61cathepsin S [Source:MGI Symbol;Acc:MGI:107341][more]
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BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P07711|CATL1_HUMAN4.460e-9846.22Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 ... [more]
sp|Q9GKL8|CATL1_CHLAE1.769e-9747.53Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CT... [more]
sp|Q9GL24|CATL1_CANLF8.375e-9545.92Cathepsin L1 OS=Canis lupus familiaris OX=9615 GN=... [more]
sp|O35186|CATK_RAT2.764e-9445.31Cathepsin K OS=Rattus norvegicus OX=10116 GN=Ctsk ... [more]
sp|P55097|CATK_MOUSE3.047e-9445.31Cathepsin K OS=Mus musculus OX=10090 GN=Ctsk PE=1 ... [more]
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BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2U8U4471.407e-11453.12Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1[more]
A0A267H1I68.831e-11256.09Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GVB71.238e-11156.09Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1Z5KUE43.477e-11151.20Uncharacterized protein (Fragment) OS=Ornithodoros... [more]
W4YG828.298e-10951.50Uncharacterized protein OS=Strongylocentrotus purp... [more]
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BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-26g8.54.915e-9747.79cathepsin L1-like [Source:NCBI gene;Acc:103028700][more]
ENSAMXT00000047972.11.370e-9448.05pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
ENSAMXT00000001927.23.548e-9447.79cathepsin L1-like [Source:NCBI gene;Acc:107197646][more]
ctsl.16.299e-9248.70cathepsin L1-like [Source:NCBI gene;Acc:103023607][more]
ctsl.11.977e-9150.33cathepsin L1-like [Source:NCBI gene;Acc:103027561][more]
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BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000011285.12.539e-10053.18pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gen... [more]
ENSPMAT00000003800.15.720e-9752.94pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 g... [more]
ENSPMAT00000006499.13.415e-9647.95pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 g... [more]
ENSPMAT00000010475.19.611e-9650.87pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 ... [more]
ENSPMAT00000007755.16.412e-8848.54pep scaffold:Pmarinus_7.0:GL476381:1843:17023:-1 g... [more]
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BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO464652.381e-10451.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO367273.339e-9745.99Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459533.684e-9747.62Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458523.235e-9147.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO427513.948e-6444.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.11.287e-9749.19cathepsin L1 [Source:NCBI gene;Acc:101171789][more]
ctsl3.903e-9347.65cathepsin L [Source:NCBI gene;Acc:100049246][more]
ctsk1.269e-8743.33cathepsin K [Source:NCBI gene;Acc:101164922][more]
ctss1.074e-8545.22cathepsin S [Source:NCBI gene;Acc:100049247][more]
ctss2.11.574e-8342.72cathepsin S [Source:NCBI gene;Acc:101165175][more]
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BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000049781.10.000e+097.55SMESG000049781.1[more]
SMESG000049783.10.000e+095.71SMESG000049783.1[more]
SMESG000049555.13.656e-17068.58SMESG000049555.1[more]
SMESG000049555.12.121e-16969.11SMESG000049555.1[more]
SMESG000049555.15.910e-15771.28SMESG000049555.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023109 ID=SMED30023109|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1207bp
GTAAATTGAGGGGCCTCAACTGTCACCTTCTGATGCGCATCGAATTCATA
TTGGGTCTATTATTATGGATAACAATTGAAATCTTTCAAACTATTCTCAA
AGATAAAAAGCTCTACAAAATAAACGCTTGTTAAATTTCAAATGAGAATT
TTAACTGTAACTCCATATTTGCTTAGCTTTTTTGCCATTAGTATTGCGCT
GAATCTTGAGTTGAATGACCAATGGAAACTTTACATGAAGATCTACAACA
AAACCTATGAGAACCCTTTCCATGAGTTGATCCGTCGAATGATATGGGAA
GACAATTTGAAATACATTCATAAACACAATCTTGATCATGATCTAGGCTT
GTATACCTTTACATTGGGTATCAATCAGTTCGCCGACTTGACTCATGCAG
AATTCAAAGCGATTTATCTGTCGGGAAATCTCAGACCCAATAAAACAGGA
AACACATATTTACCACCATTAAATGCATTCAATGTACCGGCTAATGTAGA
TTGGACAGAAAAAGGCTATGTTACTGATGTAAAGGATCAGGGTAAGTGTG
GAAGCTGTTGGGCATTTTCAACAACGGGATCTTTGGAAGGGCAGTTCTTT
CGCAAAACTGGACGTTTGGTCAGTTTTTCAGAACAGCAATTGGTCGATTG
TAGCATAAGTAATTATGGATGTCATGGAGGTTTAATGACTTCCGCCTTTA
ATGACATTAAAGACCTTGGAGGAATAGAGTCAGAACAGGAGTATCCTTAT
AAAGCTCAACAATTAAATTGCGTATTCAACCGTTCCAAAGTGGTCACCTC
CGTCAGCGGCTACAAGGAAATAGATGAGAATGAAGGAAGTTTAGCGATTG
CAGTGGCCAATGAAGGACCAATCTCGGTTGGAATTAGCGTATCTCTGAAC
TTTCAGTTATATAAATCAGGAGTTTACAATGAGCCTGACTGTTCTCGAGT
TCCTAATCATGGAGTTTTGGTGGTAGGATACGGCACAAGCGTAAATGATA
ACTACTGGATCGTGAAGAACAGTTGGGGTCCATTGTGGGGAATGAAAGGA
TACATCTGGATGAGCAAAGACAAGGACAACCAATGCGCAATTGCATCCTT
TGCCAGTTTTCCTGTGATTTGAGGGATTTTTTATGGTTCGATGAATTACG
TAGTTAATAAACAGCAAAATACTTTTTAATATAGATTTCTTTCATTTTAA
AAAAAAA
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protein sequence of SMED30023109-orf-1

>SMED30023109-orf-1 ID=SMED30023109-orf-1|Name=SMED30023109-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=327bp
MRILTVTPYLLSFFAISIALNLELNDQWKLYMKIYNKTYENPFHELIRRM
IWEDNLKYIHKHNLDHDLGLYTFTLGINQFADLTHAEFKAIYLSGNLRPN
KTGNTYLPPLNAFNVPANVDWTEKGYVTDVKDQGKCGSCWAFSTTGSLEG
QFFRKTGRLVSFSEQQLVDCSISNYGCHGGLMTSAFNDIKDLGGIESEQE
YPYKAQQLNCVFNRSKVVTSVSGYKEIDENEGSLAIAVANEGPISVGISV
SLNFQLYKSGVYNEPDCSRVPNHGVLVVGYGTSVNDNYWIVKNSWGPLWG
MKGYIWMSKDKDNQCAIASFASFPVI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000054dorsal region of the epidermis
PLANA:0000418head
PLANA:0000429neoblast
PLANA:0002032epidermal cell
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR039417Peptidase_C1A_papain-like
IPR038765Papain-like_cys_pep_sf
IPR000668Peptidase_C1A_C
IPR013201Prot_inhib_I29
IPR025661Pept_asp_AS
IPR000169Pept_cys_AS
Vocabulary: molecular function
TermDefinition
GO:0008234cysteine-type peptidase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000668Peptidase C1A, papain C-terminalPRINTSPR00705PAPAINcoord: 133..148
score: 64.62
coord: 273..283
score: 59.91
coord: 288..294
score: 79.08
IPR000668Peptidase C1A, papain C-terminalSMARTSM00645pept_c1coord: 115..325
e-value: 1.9E-104
score: 363.0
IPR000668Peptidase C1A, papain C-terminalPFAMPF00112Peptidase_C1coord: 115..324
e-value: 2.1E-77
score: 260.1
IPR013201Cathepsin propeptide inhibitor domain (I29)SMARTSM00848Inhibitor_I29_2coord: 28..88
e-value: 8.9E-26
score: 101.6
IPR013201Cathepsin propeptide inhibitor domain (I29)PFAMPF08246Inhibitor_I29coord: 28..88
e-value: 5.9E-14
score: 52.2
NoneNo IPR availableGENE3DG3DSA:3.90.70.10coord: 19..326
e-value: 3.4E-108
score: 363.9
NoneNo IPR availablePANTHERPTHR12411CYSTEINE PROTEASE FAMILY C1-RELATEDcoord: 18..325
NoneNo IPR availablePANTHERPTHR12411:SF631coord: 18..325
IPR025661Cysteine peptidase, asparagine active sitePROSITEPS00640THIOL_PROTEASE_ASNcoord: 288..307
IPR000169Cysteine peptidase, cysteine active sitePROSITEPS00139THIOL_PROTEASE_CYScoord: 133..144
IPR039417Papain-like cysteine endopeptidaseCDDcd02248Peptidase_C1Acoord: 116..324
e-value: 3.60496E-109
score: 314.562
IPR038765Papain-like cysteine peptidase superfamilySUPERFAMILYSSF54001Cysteine proteinasescoord: 19..325