Speedy protein A

Overview
NameSpeedy protein A
Smed IDSMED30023066
Length (bp)1052
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Speedy protein A (SMED30023066) t-SNE clustered cells

Violin plots show distribution of expression levels for Speedy protein A (SMED30023066) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023066

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30023066SMESG000077547.1 Contig7216newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30023066SMESG000077547.1 Contig7216uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
X1 cellSMED30023066SMESG000077547.1 SmedASXL_005443SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30023066SMESG000077547.1 dd_Smed_v4_29468_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30023066SMESG000077547.1 dd_Smed_v4_29468_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30023066SMESG000077547.1 dd_Smed_v4_29468_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
testisSMED30023066SMESG000077547.1 KU852682smed_ncbi_20200123PMID:27330085
Iyer et al., 2016		whole organism adult hermaphrodite colorimetric in situ hybridization evidence
male germ cellSMED30023066SMESG000077547.1 KU852682smed_ncbi_20200123PMID:27330085
Iyer et al., 2016		whole organism adult hermaphrodite colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Speedy protein A vs. Ensembl Human
Match: SPDYA (speedy/RINGO cell cycle regulator family member A [Source:HGNC Symbol;Acc:HGNC:30613])

HSP 1 Score: 191.815 bits (486), Expect = 5.530e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            V++  ++  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   65 VIQRQDMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVQLPRGPSATPVDCSLC 231
[Close]
BLAST of Speedy protein A vs. Ensembl Human
Match: SPDYA (speedy/RINGO cell cycle regulator family member A [Source:HGNC Symbol;Acc:HGNC:30613])

HSP 1 Score: 191.815 bits (486), Expect = 5.530e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            V++  ++  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   65 VIQRQDMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVQLPRGPSATPVDCSLC 231
[Close]
BLAST of Speedy protein A vs. Ensembl Human
Match: SPDYC (speedy/RINGO cell cycle regulator family member C [Source:HGNC Symbol;Acc:HGNC:32681])

HSP 1 Score: 158.688 bits (400), Expect = 1.769e-45
Identity = 72/161 (44.72%), Postives = 102/161 (63.35%), Query Frame = 1 
Query:  325 QFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            Q F  + ED  + +FL  D C   +DKYLLAM+  +F+R +  + EY  ++ F+ LYLA+D+EED E  K EIFPW LG  W   +  FL ++D +WARM +RA+VS++CCEE+M+  P H  W R+R  HHGG ++     + + +PRGP LSP  C  C
Sbjct:   60 QAFLSLLEDSFVQEFLSKDPCFQISDKYLLAMVLVYFQRAHLKLSEYTHSSLFLALYLANDMEEDLEGPKCEIFPWALGKDWCLRVGKFLHQRDKLWARMGFRAVVSRQCCEEVMAKEPFHWAWTRDRRPHHGG-VQRVCPQVPVRLPRGPGLSPPHCSPC 219
[Close]
BLAST of Speedy protein A vs. Ensembl Human
Match: SPDYE16 (speedy/RINGO cell cycle regulator family member E16 [Source:HGNC Symbol;Acc:HGNC:51512])

HSP 1 Score: 97.8265 bits (242), Expect = 8.776e-23
Identity = 51/126 (40.48%), Postives = 78/126 (61.90%), Query Frame = 1 
Query:  331 FKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRER 708
            F  + ED +I +FL  DK    +DKYLLAM+ A+F R     W+Y R +FF+ LYLA+D+EED+ED K  IF ++     R+ I++F + +   +  M+ RA VS++  EE+ +  P H +W R+R
Sbjct:  159 FNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEDPKQNIFYFLKN---RSQIALFQKLRFQFFCSMSGRAWVSREELEEIQAYDPEHWVWARDR 281
[Close]
BLAST of Speedy protein A vs. Ensembl Human
Match: SPDYE16 (speedy/RINGO cell cycle regulator family member E16 [Source:HGNC Symbol;Acc:HGNC:51512])

HSP 1 Score: 97.8265 bits (242), Expect = 1.000e-22
Identity = 51/126 (40.48%), Postives = 78/126 (61.90%), Query Frame = 1 
Query:  331 FKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRER 708
            F  + ED +I +FL  DK    +DKYLLAM+ A+F R     W+Y R +FF+ LYLA+D+EED+ED K  IF ++     R+ I++F + +   +  M+ RA VS++  EE+ +  P H +W R+R
Sbjct:  159 FNRLLEDPVIKRFLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEDPKQNIFYFLKN---RSQIALFQKLRFQFFCSMSGRAWVSREELEEIQAYDPEHWVWARDR 281
[Close]
BLAST of Speedy protein A vs. Ensembl Zebrafish
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:ZFIN;Acc:ZDB-GENE-041010-194])

HSP 1 Score: 194.897 bits (494), Expect = 6.171e-60
Identity = 96/207 (46.38%), Postives = 131/207 (63.29%), Query Frame = 1 
Query:  187 SPKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
             P+K R      +S D   +     P P +        +++  E+  FF+L D+D +I  FL MD CC   DKYLLAM F +F+R  FSI E++R NFF+ LYLA+ +EED E+ KYEIFPW LG  WR +   FL+++D +WAR+ YRA VS++CCEE+M+I P+H +WQRER  HH GA R  +   ++ VPRGP  SP+ CF C
Sbjct:   25 GPRKTRPGSAGRNSADSSQQPRTKTPGPTL--------LIQRQEMAAFFRLFDDD-LIQDFLWMDCCCKLTDKYLLAMTFVYFRRARFSIGEHSRINFFLALYLANTMEEDEEETKYEIFPWALGKSWRKHFPRFLKQRDQLWARIEYRAAVSRRCCEEVMAIVPSHFVWQRERAEHHSGAQRLQQNREEILVPRGPAASPEPCFLC 222
[Close]
BLAST of Speedy protein A vs. Ensembl Zebrafish
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:ZFIN;Acc:ZDB-GENE-041010-194])

HSP 1 Score: 192.971 bits (489), Expect = 8.175e-60
Identity = 96/207 (46.38%), Postives = 131/207 (63.29%), Query Frame = 1 
Query:  187 SPKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
             P+K R      +S D   +     P P +        +++  E+  FF+L D+D +I  FL MD CC   DKYLLAM F +F+R  FSI E++R NFF+ LYLA+ +EED E+ KYEIFPW LG  WR +   FL+++D +WAR+ YRA VS++CCEE+M+I P+H +WQRER  HH GA R  +   ++ VPRGP  SP+ CF C
Sbjct:   25 GPRKTRPGSAGRNSADSSQQPRTKTPGPTL--------LIQRQEMAAFFRLFDDD-LIQDFLWMDCCCKLTDKYLLAMTFVYFRRARFSIGEHSRINFFLALYLANTMEEDEEETKYEIFPWALGKSWRKHFPRFLKQRDQLWARIEYRAAVSRRCCEEVMAIVPSHFVWQRERAEHHSGAQRLQQNREEILVPRGPAASPEPCFLC 222
[Close]
BLAST of Speedy protein A vs. Ensembl Zebrafish
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:ZFIN;Acc:ZDB-GENE-041010-194])

HSP 1 Score: 194.126 bits (492), Expect = 2.267e-59
Identity = 96/207 (46.38%), Postives = 131/207 (63.29%), Query Frame = 1 
Query:  187 SPKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
             P+K R      +S D   +     P P +        +++  E+  FF+L D+D +I  FL MD CC   DKYLLAM F +F+R  FSI E++R NFF+ LYLA+ +EED E+ KYEIFPW LG  WR +   FL+++D +WAR+ YRA VS++CCEE+M+I P+H +WQRER  HH GA R  +   ++ VPRGP  SP+ CF C
Sbjct:   25 GPRKTRPGSAGRNSADSSQQPRTKTPGPTL--------LIQRQEMAAFFRLFDDD-LIQDFLWMDCCCKLTDKYLLAMTFVYFRRARFSIGEHSRINFFLALYLANTMEEDEEETKYEIFPWALGKSWRKHFPRFLKQRDQLWARIEYRAAVSRRCCEEVMAIVPSHFVWQRERAEHHSGAQRLQQNREEILVPRGPAASPEPCFLC 222
[Close]
BLAST of Speedy protein A vs. Ensembl Zebrafish
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:ZFIN;Acc:ZDB-GENE-041010-194])

HSP 1 Score: 194.126 bits (492), Expect = 2.267e-59
Identity = 96/207 (46.38%), Postives = 131/207 (63.29%), Query Frame = 1 
Query:  187 SPKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
             P+K R      +S D   +     P P +        +++  E+  FF+L D+D +I  FL MD CC   DKYLLAM F +F+R  FSI E++R NFF+ LYLA+ +EED E+ KYEIFPW LG  WR +   FL+++D +WAR+ YRA VS++CCEE+M+I P+H +WQRER  HH GA R  +   ++ VPRGP  SP+ CF C
Sbjct:   25 GPRKTRPGSAGRNSADSSQQPRTKTPGPTL--------LIQRQEMAAFFRLFDDD-LIQDFLWMDCCCKLTDKYLLAMTFVYFRRARFSIGEHSRINFFLALYLANTMEEDEEETKYEIFPWALGKSWRKHFPRFLKQRDQLWARIEYRAAVSRRCCEEVMAIVPSHFVWQRERAEHHSGAQRLQQNREEILVPRGPAASPEPCFLC 222
[Close]
BLAST of Speedy protein A vs. Ensembl Xenopus
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:NCBI gene;Acc:100127607])

HSP 1 Score: 197.208 bits (500), Expect = 3.478e-60
Identity = 93/171 (54.39%), Postives = 120/171 (70.18%), Query Frame = 1 
Query:  295 AYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
              +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F I EYNR NFF  LYLA+ VEED+E+ KYEIFPW LG  WR     FL+ +D++W++++YRA VS++CCEE+M+I P+H IWQRER  HH GA RNY K   + +PRGP+ +P  C  C
Sbjct:   61 GLIIQRKEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAGFHIHEYNRRNFFAALYLANTVEEDDEESKYEIFPWALGDKWRKLYPNFLRSRDELWSKIDYRAAVSRRCCEEVMAIAPSHYIWQRERSEHHSGAARNYSK-YDVYLPRGPSATPLDCPVC 229
[Close]
BLAST of Speedy protein A vs. Ensembl Xenopus
Match: washc4 (WASH complex subunit 4 [Source:Xenbase;Acc:XB-GENE-5914213])

HSP 1 Score: 188.734 bits (478), Expect = 3.095e-56
Identity = 84/161 (52.17%), Postives = 111/161 (68.94%), Query Frame = 1 
Query:  328 FFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCH 810
            F++L+ E+++I +FL MD C   +DKYL+AM+ A+FKR      EY   NFF+ LYLA+D+EED ED KYEIFPW LG  WR     FL+ +D+ WA+MNYRA+VS+KCC+E+MS  P H  W R RP HH GA+R Y ++     PRGP L+P +C  CH
Sbjct:  139 FYRLL-ENELIQEFLSMDSCLKISDKYLIAMVLAYFKRAGLYTSEYTAMNFFVALYLANDMEEDEEDFKYEIFPWALGDSWREIFPQFLRLRDNFWAKMNYRAVVSRKCCDEVMSKDPTHWAWLRNRPVHHSGALRGYLRNEDDFFPRGPGLTPASCALCH 298
[Close]
BLAST of Speedy protein A vs. Ensembl Xenopus
Match: nup133 (nucleoporin 133kDa [Source:Xenbase;Acc:XB-GENE-999348])

HSP 1 Score: 115.931 bits (289), Expect = 7.120e-30
Identity = 59/139 (42.45%), Postives = 86/139 (61.87%), Query Frame = 1 
Query:  304 VKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIY-PNHSIWQRERPYH 717
            V+  E   +F+L+  DK IM FL+ D+    ADKYLLA++  +FKR    + E+ R NF + LYLAH++EED +  K  +  WVLG   +     F++K+D    +M+YRAIVSK  C+ELM+ + P+H  W R+R  H
Sbjct:   55 VEEAEAEAYFQLLS-DKKIMSFLQKDRFYKIADKYLLAIVLIYFKRAGLKVDEFTRQNFVVSLYLAHEIEEDTDIPKMAMLAWVLGKNLKEKRRNFIRKRDRFLQQMDYRAIVSKSECDELMAQHNPSHWAWLRDRSEH 192
[Close]
BLAST of Speedy protein A vs. Ensembl Xenopus
Match: pdzrn3 (PDZ domain containing ring finger 3 [Source:Xenbase;Acc:XB-GENE-5817964])

HSP 1 Score: 115.161 bits (287), Expect = 1.029e-29
Identity = 62/143 (43.36%), Postives = 86/143 (60.14%), Query Frame = 1 
Query:  304 VKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIY-PNHSIWQRERPYHHGGA 729
            V+  E   +F+L+  DK IM FL+ D+    ADKYLLA++  +FKR    I E+NR NF + LYLAH++EED +     +  WVLG   +     FL+K D    +M+YRAIVSK  C+ELM+ + P+H  W R+R  H   A
Sbjct:   24 VEEAEAEAYFQLLS-DKKIMSFLQKDRFYKIADKYLLAIVLIYFKRVGLKIDEFNRQNFVLSLYLAHEIEEDTDIPTMAMLAWVLGKNLKEKRRNFLRKWDRFLQQMDYRAIVSKSECDELMAQHNPSHWAWLRDRSEHLESA 165
[Close]
BLAST of Speedy protein A vs. Ensembl Xenopus
Match: ENSXETT00000004694.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:7:32959654:32961186:-1 gene:ENSXETG00000000200.1 transcript:ENSXETT00000004694.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 109.383 bits (272), Expect = 2.047e-27
Identity = 58/133 (43.61%), Postives = 81/133 (60.90%), Query Frame = 1 
Query:  349 DKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIY-PNHSIWQRERPYHHGGAIRNYK 744
            DK IM FL+ D+    ADKYLLA++  +FKR    I E+NR NFF+ LYLAHD+EED +  K  +  WVLG   +     FL+K D    ++ YRA+VSK  C+ELM  + P+H  W ++R      AI +++
Sbjct:   43 DKKIMSFLQKDRFYKIADKYLLAIVLIYFKRGGIKIEEFNRQNFFLSLYLAHDIEEDTDIPKITMLAWVLGKNLKEKCRNFLRKWDRFLQQIIYRAVVSKSECDELMGQHNPSHWAWLKDRSEDPESAIGSHE 175
[Close]
BLAST of Speedy protein A vs. Ensembl Mouse
Match: Spdya (speedy/RINGO cell cycle regulator family, member A [Source:MGI Symbol;Acc:MGI:1918141])

HSP 1 Score: 191.045 bits (484), Expect = 2.538e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. Ensembl Mouse
Match: Spdya (speedy/RINGO cell cycle regulator family, member A [Source:MGI Symbol;Acc:MGI:1918141])

HSP 1 Score: 191.43 bits (485), Expect = 3.902e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. Ensembl Mouse
Match: Spdya (speedy/RINGO cell cycle regulator family, member A [Source:MGI Symbol;Acc:MGI:1918141])

HSP 1 Score: 191.43 bits (485), Expect = 4.279e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. Ensembl Mouse
Match: Spdya (speedy/RINGO cell cycle regulator family, member A [Source:MGI Symbol;Acc:MGI:1918141])

HSP 1 Score: 191.43 bits (485), Expect = 4.279e-58
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. Ensembl Mouse
Match: Spdye4a (speedy/RINGO cell cycle regulator family, member E4A [Source:MGI Symbol;Acc:MGI:1921923])

HSP 1 Score: 89.3521 bits (220), Expect = 4.817e-20
Identity = 47/127 (37.01%), Postives = 76/127 (59.84%), Query Frame = 1 
Query:  328 FFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRER 708
            F KL+ ED ++ KFL  DK    +DKYLL+M+ A+F R     W+Y   +FF+ LYLA+D+EEDN+  K +IF ++ G  +     +F + +      M ++  VS++ CEE+ +  P+  +W R+R
Sbjct:  140 FTKLL-EDPVVKKFLTWDKMLRVSDKYLLSMVIAYFSRAGLFSWQYRPIHFFLALYLANDMEEDNQAPKQDIFYFLYGKSYAQR-PMFHKLRFQFIRSMGWKIWVSREECEEIQAYNPDLWVWARDR 264
[Close]
BLAST of Speedy protein A vs. UniProt/SwissProt
Match: sp|Q5MJ70|SPDYA_HUMAN (Speedy protein A OS=Homo sapiens OX=9606 GN=SPDYA PE=1 SV=2)

HSP 1 Score: 191.815 bits (486), Expect = 2.655e-57
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            V++  ++  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   65 VIQRQDMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVQLPRGPSATPVDCSLC 231
[Close]
BLAST of Speedy protein A vs. UniProt/SwissProt
Match: sp|Q5IBH7|SPDYA_MOUSE (Speedy protein A OS=Mus musculus OX=10090 GN=Spdya PE=1 SV=2)

HSP 1 Score: 191.43 bits (485), Expect = 2.993e-57
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P H IWQRER  HH GA+RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. UniProt/SwissProt
Match: sp|Q8R496|SPDYA_RAT (Speedy protein A OS=Rattus norvegicus OX=10116 GN=Spdya PE=2 SV=1)

HSP 1 Score: 191.045 bits (484), Expect = 5.294e-57
Identity = 94/169 (55.62%), Postives = 121/169 (71.60%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            +++  E+  FFKL D+D +I  FL MD CC  ADKYLLAM F +FKR  F+I E+ R NFFI LYLA+ VEED E+ KYEIFPW LG  WR     FL+ +D +W R++YRAIVS++CCEE+M+I P+H IWQRER  HH GA RNY +D ++ +PRGP+ +P  C  C
Sbjct:   64 IIQRQEMTAFFKLFDDD-LIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPSHYIWQRERSVHHSGAARNYNRD-EVHLPRGPSATPVDCSLC 230
[Close]
BLAST of Speedy protein A vs. UniProt/SwissProt
Match: sp|Q9PU13|SPD1A_XENLA (Speedy protein 1-A OS=Xenopus laevis OX=8355 GN=spdya-a PE=1 SV=2)

HSP 1 Score: 169.474 bits (428), Expect = 7.741e-49
Identity = 87/180 (48.33%), Postives = 119/180 (66.11%), Query Frame = 1 
Query:  271 IIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCH 810
            ++RN  +    ++  E   F++L+ E++ I +FL MD C   +DKYL+AM+ A+FKR      EY   NFF+ LYLA+D+EED ED KYEIFPW LG  WR     FL+ +DD WA+MNYRA+VS++CC+E+MS  P H  W R+RP HH GA+R Y ++     PRGP L+P +C  CH
Sbjct:   51 MVRNTHLN---LQPQERQAFYRLL-ENEQIQEFLSMDSCLRISDKYLIAMVLAYFKRAGLYTSEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWRELFPQFLRLRDDFWAKMNYRAVVSRRCCDEVMSKDPTHWAWLRDRPIHHSGAMRGYLRNEDDFSPRGPGLTPASCTLCH 226
[Close]
BLAST of Speedy protein A vs. UniProt/SwissProt
Match: sp|Q9YGL1|SPD1B_XENLA (Speedy protein 1-B OS=Xenopus laevis OX=8355 GN=spdya-b PE=1 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 2.029e-48
Identity = 82/161 (50.93%), Postives = 112/161 (69.57%), Query Frame = 1 
Query:  328 FFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCH 810
            F++L+ E+++I +FL MD C   +DKYL+AM+ A+FKR      EY   NFF+ LYLA+D+EED ED KYEIFPW LG  WR     FL+ +D+ WA+MNYRA+VS++CC+E+M+  P H  W R+RP HH GA+R Y ++     PRGP L+P +C  CH
Sbjct:   67 FYRLL-ENELIQEFLSMDSCLKISDKYLIAMVLAYFKRAGLYTGEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWREFFPQFLRLRDNFWAKMNYRAVVSRRCCDEVMAKDPTHWAWLRDRPIHHSGALRGYLRNEDDFFPRGPGLTPASCALCH 226
[Close]
BLAST of Speedy protein A vs. TrEMBL
Match: A0A172RVQ4 (RINGO-SPY protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 365.925 bits (938), Expect = 4.109e-125
Identity = 175/175 (100.00%), Postives = 175/175 (100.00%), Query Frame = 1 
Query:  460 EYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED 984
            EYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED
Sbjct:    2 EYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED 176
[Close]
BLAST of Speedy protein A vs. TrEMBL
Match: A0A074ZU95 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_02613 PE=4 SV=1)

HSP 1 Score: 253.832 bits (647), Expect = 1.197e-78
Identity = 136/275 (49.45%), Postives = 171/275 (62.18%), Query Frame = 1 
Query:   40 MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSRKRSNLRITPSCSPKKLRLSKNE----NHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC-----HPELSTSLHD 837
            M+ +LNWF+ IS           G +  +N     ++ K+ N+R TPS +                S    + GN AP   ++ +NM+ AYVV+  E+  FF LI+ DKII  FL+ DKC  +ADK++LA +FA+FKRCNF   EYNR NFF CLYLAHD+EED+EDLKYEIFPW LG  WR  IS FL +K+ IWARMNYRAIVS  CC+ELMSI P H IW R R  HHG AIR Y K    ++P+GP+ SPK CF+C     H  LST+  D
Sbjct:    1 MDWALNWFESIS-------QKPLGCRKRKNDIEQINTVKKKNIRHTPSTAGIVAGAEPTTFMKYAASPKFIMNGNWAPSPEVLESNMLSAYVVQTKEMNDFFALIENDKIIKGFLDSDKCFKYADKFILACVFAYFKRCNFKPKEYNRINFFCCLYLAHDMEEDDEDLKYEIFPWALGKMWRQKISSFLLRKETIWARMNYRAIVSYMCCKELMSIMPTHPIWTRTRLTHHGHAIRTYAKPRDSNIPKGPDSSPKPCFECDIFYNHHYLSTTYTD 268
[Close]
BLAST of Speedy protein A vs. TrEMBL
Match: A0A4S2LZQ8 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_003878 PE=4 SV=1)

HSP 1 Score: 249.21 bits (635), Expect = 9.943e-77
Identity = 128/260 (49.23%), Postives = 166/260 (63.85%), Query Frame = 1 
Query:   40 MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSRKRSNLRITPSCSPKKLRLSKNE----NHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            M+ +LNWF+ IS           G +  +N    +++ ++ N+R TPS +                S    + GN AP   ++ +NM+ AYVV+  E+ +FF L++ DKII  FL+ DKC  +ADK++LA +FA+FKRCNF   EYNR NFF CLYLAHD+EED+EDLKYEIFPW LG  WR  IS FL +K+ IWARMNYRAIVS  CC+ELMSI P H IW+R R  HHG AIR Y K    ++PRGP  SP+ C +C
Sbjct:    1 MDWALNWFESIS-------QKPLGCRKRKNDIEQTNTVRKKNIRHTPSTAGIVASTEPTTFMKYAASPKFIMNGNWAPSPQVLESNMLSAYVVQTKEMNEFFALLENDKIIKGFLDSDKCFKYADKFILACVFAYFKRCNFKSKEYNRINFFCCLYLAHDMEEDDEDLKYEIFPWALGKMWRQKISSFLLRKETIWARMNYRAIVSYMCCKELMSIMPAHPIWRRNRLTHHGYAIRTYAKPRDSNIPRGPYSSPQPCSEC 253
[Close]
BLAST of Speedy protein A vs. TrEMBL
Match: A0A2H1CL22 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_04430 PE=4 SV=1)

HSP 1 Score: 247.284 bits (630), Expect = 1.334e-75
Identity = 134/267 (50.19%), Postives = 177/267 (66.29%), Query Frame = 1 
Query:   40 MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSR-KRSNLRITP------SC-SPKKLRLSKN--ENHSDDVFLK-GNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            M+ SL+WF+ ISP      +   G K  R    IS +   R N+R TP       C SP   +  +N  +N +   F++ GN AP   +  NN IKAYVV+ VE+ ++F L+++D++I KFLE D C  +ADKYLLA +FA+FKRCNF + EYNR NFF CLY+AHD+EED+ED KYEIFPW LG +WR  I  F+Q+K+ IWARMNYRAIVS +CC+EL+SI P+H IW+R R   HG A+R Y K  + S+PRGP+  P+ C  C
Sbjct:    1 MDWSLSWFEAISP------HVIRGRK--RCIAEISETVVHRKNVRRTPCFTVYEKCRSPVYGQTKQNVLDNIASPRFIRNGNKAPSIEMAENNFIKAYVVRSVEMTEYFHLLEKDEVIKKFLEHDICFNYADKYLLACVFAYFKRCNFKLQEYNRMNFFSCLYIAHDMEEDDEDYKYEIFPWALGSFWREKIPAFIQRKEMIWARMNYRAIVSYQCCKELISIAPDHPIWKRNRASVHGLAMRTYLKSDETSLPRGPSRPPRKCDLC 259
[Close]
BLAST of Speedy protein A vs. TrEMBL
Match: A0A4E0RGW8 (Rapid inducer of G2/M progression in oocytes A OS=Fasciola hepatica OX=6192 GN=D915_002896 PE=4 SV=1)

HSP 1 Score: 238.424 bits (607), Expect = 2.059e-72
Identity = 134/279 (48.03%), Postives = 177/279 (63.44%), Query Frame = 1 
Query:   40 MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSR-KRSNLRITP------SC-SPKKLRLSKN--ENHSDDVFLK-GNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEE------------LMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            M+ SL+WF+ ISP      +   G K  R    IS +   R N+R TP       C SP   +  +N  +N +   F++ GN AP   +  NN IKAYVV+ VE+ ++F L+++D++I KFLE D C  +ADKYLLA +FA+FKRCNF + EYNR NFF CLY+AHD+EED+ED KYEIFPW LG +WR  I  F+Q+K+ IWARMNYRAIVS +CC+E            L+SI P+H IW+R R   HG A+R Y K  + S+PRGP+  P+ C  C
Sbjct:    1 MDWSLSWFEAISP------HVIRGRK--RCIAEISETVVHRKNVRRTPCFTVYEKCRSPVYGQTKQNVLDNIASPRFIRNGNKAPSIEMAENNFIKAYVVRSVEMTEYFHLLEKDEVIKKFLEHDICFNYADKYLLACVFAYFKRCNFKLQEYNRMNFFSCLYIAHDMEEDDEDYKYEIFPWALGSFWREKIPAFIQRKEMIWARMNYRAIVSYQCCKEVSKWPTFCKRLQLISIAPDHPIWKRNRASVHGLAMRTYLKSDETSLPRGPSRPPRKCDLC 271
[Close]
BLAST of Speedy protein A vs. Ensembl Cavefish
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:NCBI gene;Acc:103046103])

HSP 1 Score: 188.734 bits (478), Expect = 6.693e-57
Identity = 92/169 (54.44%), Postives = 119/169 (70.41%), Query Frame = 1 
Query:  301 VVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKC 807
            V++  E+  FF+L D+D +I  FL MD CC   DKYLLAM F +FKR  FSI E++R NFFI LYLA+ +EED E+ KYEIFPW LG  WR     FL+++D +WAR+ YRA VS++CCEE+M+I P+H IWQRER  HH GA R Y+   ++ +PRGP  SP+ C  C
Sbjct:   85 VIQRQEMAAFFRLFDDD-LIQDFLWMDCCCKLTDKYLLAMAFVYFKRARFSISEHSRMNFFIALYLANTMEEDEEEPKYEIFPWALGKSWRKLFPCFLKQRDKLWARIEYRAAVSRRCCEEVMAIVPSHFIWQRERAEHHSGAQRQYRDRDEVHMPRGPAASPEPCSLC 252
[Close]
BLAST of Speedy protein A vs. Ensembl Nematostella
Match: EDO43042 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZS3])

HSP 1 Score: 164.466 bits (415), Expect = 4.069e-50
Identity = 82/157 (52.23%), Postives = 111/157 (70.70%), Query Frame = 1 
Query:  346 EDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKK--DIKLSVPRGPNLSPKTCFKCH 810
            +D +I +FL MDKC   +DKYLL+M++A+F+R N    E+NR NFF+ LYLA+D+EED ED KY+IFPW LG  WR     FL ++D++W +M YRA+VS++ CEE+MSI P+H +W R R  HHGGA R+Y K  + + + PRG N SP  C  CH
Sbjct:    1 DDDVIREFLWMDKCAKISDKYLLSMVYAYFRRANLHRREFNRLNFFLALYLANDMEEDEEDDKYDIFPWALGKRWRELYPAFLVRRDELWRKMRYRAVVSRQTCEEVMSIAPDHPVWWRRRRSHHGGAWRDYTKSEEDQSASPRGHNSSPVFCSMCH 157
[Close]
BLAST of Speedy protein A vs. Ensembl Medaka
Match: spdya (speedy/RINGO cell cycle regulator family member A [Source:NCBI gene;Acc:101164445])

HSP 1 Score: 202.601 bits (514), Expect = 1.631e-62
Identity = 93/176 (52.84%), Postives = 120/176 (68.18%), Query Frame = 1 
Query:  283 NMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCH 810
             M+ A V++  E+  +F+L+D DK+I  FL MD C    DKYLLAM F +FKR +F+I EYNR NFFI LYLA+ +EED E  KYEIFPW LG  WR     FLQ++D +WAR+ YRA VS++CCEE+M++  +HS+WQR R  HH GA R Y  D     PRGP+ SP +C  C+
Sbjct:   50 TMLPAAVIQRQEMSSYFRLLD-DKLIHDFLRMDSCFKMTDKYLLAMTFVYFKRAHFTIAEYNRRNFFIALYLANTMEEDEEQSKYEIFPWALGKGWRKQFPRFLQQRDVLWARIQYRAAVSRRCCEEVMAVVSSHSVWQRTRSDHHSGAQRQY-SDPGSPFPRGPSASPPSCGLCN 223
[Close]
BLAST of Speedy protein A vs. Planmine SMEST
Match: SMESG000077547.1 (SMESG000077547.1)

HSP 1 Score: 645.195 bits (1663), Expect = 0.000e+0
Identity = 313/315 (99.37%), Postives = 313/315 (99.37%), Query Frame = 1 
Query:   40 MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSRKRSNLRITPSCSPKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED 984
            MNTSLNWFDDISPCANFTSN SEGSKFLRNYNFISHSRKRSNLRITPSCSPKKLRLSKNE HSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED
Sbjct:    1 MNTSLNWFDDISPCANFTSNLSEGSKFLRNYNFISHSRKRSNLRITPSCSPKKLRLSKNEKHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKLIDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFICLYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAIVSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSPKTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDDFDSKGNLNTFEKSED 315
The following BLAST results are available for this feature:
BLAST of Speedy protein A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SPDYA5.530e-5855.62speedy/RINGO cell cycle regulator family member A ... [more]
SPDYA5.530e-5855.62speedy/RINGO cell cycle regulator family member A ... [more]
SPDYC1.769e-4544.72speedy/RINGO cell cycle regulator family member C ... [more]
SPDYE168.776e-2340.48speedy/RINGO cell cycle regulator family member E1... [more]
SPDYE161.000e-2240.48speedy/RINGO cell cycle regulator family member E1... [more]
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BLAST of Speedy protein A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Speedy protein A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Speedy protein A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
spdya6.171e-6046.38speedy/RINGO cell cycle regulator family member A ... [more]
spdya8.175e-6046.38speedy/RINGO cell cycle regulator family member A ... [more]
spdya2.267e-5946.38speedy/RINGO cell cycle regulator family member A ... [more]
spdya2.267e-5946.38speedy/RINGO cell cycle regulator family member A ... [more]
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BLAST of Speedy protein A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
spdya3.478e-6054.39speedy/RINGO cell cycle regulator family member A ... [more]
washc43.095e-5652.17WASH complex subunit 4 [Source:Xenbase;Acc:XB-GENE... [more]
nup1337.120e-3042.45nucleoporin 133kDa [Source:Xenbase;Acc:XB-GENE-999... [more]
pdzrn31.029e-2943.36PDZ domain containing ring finger 3 [Source:Xenbas... [more]
ENSXETT00000004694.12.047e-2743.61pep primary_assembly:Xenopus_tropicalis_v9.1:7:329... [more]
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BLAST of Speedy protein A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Spdya2.538e-5855.62speedy/RINGO cell cycle regulator family, member A... [more]
Spdya3.902e-5855.62speedy/RINGO cell cycle regulator family, member A... [more]
Spdya4.279e-5855.62speedy/RINGO cell cycle regulator family, member A... [more]
Spdya4.279e-5855.62speedy/RINGO cell cycle regulator family, member A... [more]
Spdye4a4.817e-2037.01speedy/RINGO cell cycle regulator family, member E... [more]
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BLAST of Speedy protein A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5MJ70|SPDYA_HUMAN2.655e-5755.62Speedy protein A OS=Homo sapiens OX=9606 GN=SPDYA ... [more]
sp|Q5IBH7|SPDYA_MOUSE2.993e-5755.62Speedy protein A OS=Mus musculus OX=10090 GN=Spdya... [more]
sp|Q8R496|SPDYA_RAT5.294e-5755.62Speedy protein A OS=Rattus norvegicus OX=10116 GN=... [more]
sp|Q9PU13|SPD1A_XENLA7.741e-4948.33Speedy protein 1-A OS=Xenopus laevis OX=8355 GN=sp... [more]
sp|Q9YGL1|SPD1B_XENLA2.029e-4850.93Speedy protein 1-B OS=Xenopus laevis OX=8355 GN=sp... [more]
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BLAST of Speedy protein A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A172RVQ44.109e-125100.00RINGO-SPY protein (Fragment) OS=Schmidtea mediterr... [more]
A0A074ZU951.197e-7849.45Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A4S2LZQ89.943e-7749.23Uncharacterized protein OS=Opisthorchis felineus O... [more]
A0A2H1CL221.334e-7550.19Uncharacterized protein OS=Fasciola hepatica OX=61... [more]
A0A4E0RGW82.059e-7248.03Rapid inducer of G2/M progression in oocytes A OS=... [more]
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BLAST of Speedy protein A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
spdya6.693e-5754.44speedy/RINGO cell cycle regulator family member A ... [more]
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BLAST of Speedy protein A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Speedy protein A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Speedy protein A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO430424.069e-5052.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Speedy protein A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
spdya1.631e-6252.84speedy/RINGO cell cycle regulator family member A ... [more]
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BLAST of Speedy protein A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000077547.10.000e+099.37SMESG000077547.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023066 ID=SMED30023066|Name=Speedy protein A|organism=Schmidtea mediterranea sexual|type=transcript|length=1052bp
TAGAATTTTAAACTTTTTATTTTTCCAATTTGTTTTTAAATGAATACATC
ATTAAATTGGTTTGATGACATATCTCCCTGTGCGAATTTCACTTCAAATC
CAAGTGAAGGAAGTAAATTTTTAAGGAATTACAATTTTATAAGTCATTCG
AGAAAAAGATCGAATTTAAGAATTACACCATCTTGTTCTCCTAAAAAGCT
CAGACTGTCCAAGAACGAAAATCATTCCGATGATGTATTTTTGAAGGGTA
ACTGCGCTCCACCAACTCCAATAATTCGTAATAACATGATTAAAGCATAT
GTTGTTAAAGGAGTAGAATTATGTCAGTTTTTTAAATTAATTGATGAAGA
TAAAATTATTATGAAATTTCTTGAAATGGATAAATGTTGTATATTCGCAG
ATAAATATCTATTGGCCATGATTTTTGCCCATTTTAAGAGGTGTAATTTT
TCAATATGGGAATACAATAGGACGAATTTTTTTATTTGCTTATATCTTGC
TCACGATGTCGAAGAAGACAATGAGGATTTGAAATATGAAATATTTCCAT
GGGTTCTTGGTCCATATTGGCGGAATAACATATCAGTGTTTCTTCAGAAA
AAAGATGATATATGGGCACGAATGAATTATAGGGCCATTGTTAGTAAAAA
ATGTTGTGAAGAACTAATGTCTATTTACCCTAACCACTCTATATGGCAAC
GAGAAAGACCTTATCATCATGGTGGCGCAATTAGAAATTACAAAAAGGAT
ATCAAATTATCTGTTCCAAGAGGTCCCAATTTGTCTCCTAAAACTTGTTT
TAAATGTCACCCAGAATTGAGTACAAGTCTTCACGATTCTGCTTTCAGTA
GTCTTTGGGAATGTGAAAGTTTTAATGACAGCGACGAGTCAGATGATATC
TTGCTTTTACCTAAACAATCTATTAAACTTTATGATGACTTTGATTCTAA
AGGAAATTTAAATACATTTGAAAAATCAGAAGACTAAATTTTTGTACAGA
ATCACTTTGTTTTGGTTTTTGAACAGCAATTGGGGAAACACGATTTTAGC
AG
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protein sequence of SMED30023066-orf-1

>SMED30023066-orf-1 ID=SMED30023066-orf-1|Name=SMED30023066-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=316bp
MNTSLNWFDDISPCANFTSNPSEGSKFLRNYNFISHSRKRSNLRITPSCS
PKKLRLSKNENHSDDVFLKGNCAPPTPIIRNNMIKAYVVKGVELCQFFKL
IDEDKIIMKFLEMDKCCIFADKYLLAMIFAHFKRCNFSIWEYNRTNFFIC
LYLAHDVEEDNEDLKYEIFPWVLGPYWRNNISVFLQKKDDIWARMNYRAI
VSKKCCEELMSIYPNHSIWQRERPYHHGGAIRNYKKDIKLSVPRGPNLSP
KTCFKCHPELSTSLHDSAFSSLWECESFNDSDESDDILLLPKQSIKLYDD
FDSKGNLNTFEKSED*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0003723RNA binding
GO:0046872metal ion binding
GO:0019901protein kinase binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0000208testis
PLANA:0000228male germ cell
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR020984Speedy
Vocabulary: biological process
TermDefinition
GO:0000082G1/S transition of mitotic cell cycle
GO:0006974cellular response to DNA damage stimulus
GO:0007049cell cycle
GO:0007140male meiotic nuclear division
GO:0007275multicellular organism development
GO:0008284positive regulation of cell proliferation
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR020984Cell cycle regulatory protein SpeedyPFAMPF11357Spy1coord: 96..223
e-value: 2.4E-51
score: 173.4
NoneNo IPR availablePANTHERPTHR31545FAMILY NOT NAMEDcoord: 54..262
NoneNo IPR availablePANTHERPTHR31545:SF1SPEEDY/RINGO CELL CYCLE REGULATOR FAMILY MEMBER Acoord: 54..262