Cathepsin L2
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Overview
Neoblast Clusters
Zeng et. al., 2018
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppEmbryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30023018 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538]) HSP 1 Score: 197.208 bits (500), Expect = 1.163e-59 Identity = 127/312 (40.71%), Postives = 171/312 (54.81%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVS-DFIK--MVFTVTSNVHNIT--VLVVGYG----SLFGSNYWIVKNSWA 994
M ++L+ F + I + +F N L+ +W +K + Y E RR +WE N++ I HN EY GKH +T+ +N + D+T+ EF+ + +G N KG F + LP SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTGKL+SLSEQ LVDC+RP GN GC GG +AF YV E ++ E+ Y Y A + C Y VAN T +T + K++ ++ P + + M S F K + F + N+ VLVVGYG + S YW+VKNSW
Sbjct: 1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGP----ISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWG 304 HSP 2 Score: 59.3066 bits (142), Expect = 3.328e-9 Identity = 36/102 (35.29%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRI--------TXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYP 1077
G L AVAT+GP+SVA+D F+FYK+GIY + S N L + + + GP WG+ Y+ ++KD N GIA+ A YP
Sbjct: 231 GKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538]) HSP 1 Score: 197.208 bits (500), Expect = 1.163e-59 Identity = 127/312 (40.71%), Postives = 171/312 (54.81%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVS-DFIK--MVFTVTSNVHNIT--VLVVGYG----SLFGSNYWIVKNSWA 994
M ++L+ F + I + +F N L+ +W +K + Y E RR +WE N++ I HN EY GKH +T+ +N + D+T+ EF+ + +G N KG F + LP SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTGKL+SLSEQ LVDC+RP GN GC GG +AF YV E ++ E+ Y Y A + C Y VAN T +T + K++ ++ P + + M S F K + F + N+ VLVVGYG + S YW+VKNSW
Sbjct: 1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGP----ISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWG 304 HSP 2 Score: 59.3066 bits (142), Expect = 3.328e-9 Identity = 36/102 (35.29%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRI--------TXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYP 1077
G L AVAT+GP+SVA+D F+FYK+GIY + S N L + + + GP WG+ Y+ ++KD N GIA+ A YP
Sbjct: 231 GKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 196.438 bits (498), Expect = 2.151e-59 Identity = 125/320 (39.06%), Postives = 166/320 (51.88%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE------TILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG--SLFGSN--YWIVKNSWAQ 997
M +IL+ F + I + T + L +W +K ++ Y E RR +WE N++ I HN EY GKHS+T+ +N + D+T EF+ + N P+ + P SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTG+LISLSEQ LVDC+ P GN GC GGL AF YV+ + ++ E+ Y Y A + C YN VAN T + +I K+ + T P +SVA + +F +S + VLVVGYG S N YW+VKNSW +
Sbjct: 1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGP------------ISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGE 304 HSP 2 Score: 56.9954 bits (136), Expect = 1.576e-8 Identity = 36/99 (36.36%), Postives = 46/99 (46.46%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SVAID F FYK GIY + S + L + + + G WG G Y+ M+KD GIAS A YP +
Sbjct: 235 LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537]) HSP 1 Score: 196.438 bits (498), Expect = 2.151e-59 Identity = 125/320 (39.06%), Postives = 166/320 (51.88%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE------TILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG--SLFGSN--YWIVKNSWAQ 997
M +IL+ F + I + T + L +W +K ++ Y E RR +WE N++ I HN EY GKHS+T+ +N + D+T EF+ + N P+ + P SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTG+LISLSEQ LVDC+ P GN GC GGL AF YV+ + ++ E+ Y Y A + C YN VAN T + +I K+ + T P +SVA + +F +S + VLVVGYG S N YW+VKNSW +
Sbjct: 1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGP------------ISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGE 304 HSP 2 Score: 56.9954 bits (136), Expect = 1.576e-8 Identity = 36/99 (36.36%), Postives = 46/99 (46.46%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SVAID F FYK GIY + S + L + + + G WG G Y+ M+KD GIAS A YP +
Sbjct: 235 LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSS (cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545]) HSP 1 Score: 177.178 bits (448), Expect = 4.603e-52 Identity = 120/314 (38.22%), Postives = 160/314 (50.96%), Query Frame = 2
Query: 116 LSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQY-EPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPN-GNFGCIGGLPYQAFDY-VEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYT-------NIKKETILTWQPPWPPWDRCL*LLMSVADVSDFI--KMVFTVTSNVHNIT--VLVVGYGSLFGSNYWIVKNSWAQ-VGETG 1012
L L+ + + + L+ W L+K + KQY E EA RR+IWE NL+F+ HNLE+ +G HSY LG+N D+T E + R+ + + N LP SVDWR KG V VK Q +CG+CWAFSA GALE Q KTGKL+SLS Q LVDC+ GN GC GG AF Y ++ ++ + Y Y A +KC Y+ A + YT ++ KE + P + + + S F+ V+ S N+ VLVVGYG L G YW+VKNSW GE G
Sbjct: 4 LVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPN-RILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGP--------VSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEG 308
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 156.377 bits (394), Expect = 1.750e-44 Identity = 109/295 (36.95%), Postives = 153/295 (51.86%), Query Frame = 2
Query: 182 EEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSN--PKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWD---RCL*LLMSVADVSDFIKMVF---TVTSNVHNITVLVVGYGS-LFGSNYWIVKNSW-AQVGETG 1012
E+W+ +K F K+Y E + N+ I HN ++ LG+ ++ +GLN +D+ ++++ R+ G + S F+ N+ +P VDWR V VK+Q CGSCWAFSATGALEGQH RK G+L+SLSEQ LVDC+ GN GC GGL QAF+Y+ + ++ E+ Y Y KC +NK V A+ Y + K + T P D R L + K V+ +S + VL+VGYG+ +YWIVKNSW A GE G
Sbjct: 30 EKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDSRIKNSSSFLAPFNV-QVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQL---------YKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKG 314 HSP 2 Score: 56.6102 bits (135), Expect = 8.766e-9 Identity = 32/102 (31.37%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXX-----XXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ L AVAT GP+S+AID R F+ YK G+Y D + S L + + G WG YI ++++ N G+A++A YP++
Sbjct: 236 EGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 110.923 bits (276), Expect = 1.002e-28 Identity = 78/186 (41.94%), Postives = 100/186 (53.76%), Query Frame = 2
Query: 512 CGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVA-DVSD-----FIKMVF---TVTSNVHNITVLVVGYGS-LFGSNYWIVKNSW-AQVGETG 1012
CGSCWAFSATGALEGQH RK G+L+SLSEQ LVDC+ GN GC GGL QAF+Y+ + ++ E+ Y Y KC +NK V A+ Y + K + T P +S+A D + K V+ +S + VL+VGYG+ +YWIVKNSW A GE G
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGP------------ISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKG 175 HSP 2 Score: 56.9954 bits (136), Expect = 2.016e-9 Identity = 32/102 (31.37%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ L AVAT GP+S+AID R F+ YK G+Y D + S L + + G WG YI ++++ N G+A++A YP++
Sbjct: 97 EGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333]) HSP 1 Score: 110.923 bits (276), Expect = 1.002e-28 Identity = 78/186 (41.94%), Postives = 100/186 (53.76%), Query Frame = 2
Query: 512 CGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVA-DVSD-----FIKMVF---TVTSNVHNITVLVVGYGS-LFGSNYWIVKNSW-AQVGETG 1012
CGSCWAFSATGALEGQH RK G+L+SLSEQ LVDC+ GN GC GGL QAF+Y+ + ++ E+ Y Y KC +NK V A+ Y + K + T P +S+A D + K V+ +S + VL+VGYG+ +YWIVKNSW A GE G
Sbjct: 2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGP------------ISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKG 175 HSP 2 Score: 56.9954 bits (136), Expect = 2.016e-9 Identity = 32/102 (31.37%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ L AVAT GP+S+AID R F+ YK G+Y D + S L + + G WG YI ++++ N G+A++A YP++
Sbjct: 97 EGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: R09F10.1 (pep chromosome:WBcel235:X:8323592:8325046:1 gene:WBGene00019986.1 transcript:R09F10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R09F10.1) HSP 1 Score: 110.153 bits (274), Expect = 7.067e-27 Identity = 89/287 (31.01%), Postives = 138/287 (48.08%), Query Frame = 2
Query: 197 FKTKFHKQYEPLTEAARR--IIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVT--ENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYA-EAKKCIY--NKSKV-VANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVHNITV-------------LVVGYGSLFGSNYWIVKNSWA 994
F KF ++Y + E R I +EF + E +LG L +N ++D TD E + N+ + +F + E P+S+DWR +G + +K+Q CGSCWAF+ ++E Q+ K GKL+SLSEQ++VDC+ N GC GG A +V+ + +E EK Y Y A + +C N ++V + +F +N +E I W P V + +K +++ S + N +V ++GYG S YWIVKNSW
Sbjct: 85 FILKFDRKYTSVEEFEYRYQIFLRNVIEFEAEE--ERNLG---LDLDVNEFTDWTDEELQKMVQENKYTKYDFDTPKFEGSYLETGVIRPASIDWREQGKLTPIKNQGQCGSCWAFATVASVEAQNAIKKGKLVSLSEQEMVDCDGRNN--GCSGGYRPYAMKFVKENGLESEKEYPYSALKHDQCFLKENDTRVFIDDFRMLSN-NEEDIANWVGTKGP----------VTFGMNVVKAMYSYRSGIFNPSVEDCTEKSMGAHALTIIGYGGEGESAYWIVKNSWG 353
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196) HSP 1 Score: 109.383 bits (272), Expect = 2.764e-26 Identity = 98/312 (31.41%), Postives = 143/312 (45.83%), Query Frame = 2
Query: 149 PRRFTV-NSELNEEWELFKTKFHKQYEPLTEAARRI-IWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNR-------MNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAF-DYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETI--LTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVH-----------NITVLVVGYGSLFGSNYWIVKNSWA-QVGETG 1012
PR + + NS L+ F + K+Y E +R +++ N + IR+ + + G Y G +SD+T EFK L + M +N + + + E LP S DWR KG V VK+Q NCGSCWAFS TG +EG KL+SLSEQ+LVDC+ + + GC GGLP A+ + + + +E E Y Y + C + + + + + W P +S+ ++ ++ F VH N VL+VGYG YWIVKNSW GE G
Sbjct: 165 PRDYVIWNSFLD-----FVDRHEKKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTINEE--DLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCD--SMDQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPHDEVEMQKWLVTKGP--------ISIGLNANTLQ--FYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAG 454
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592) HSP 1 Score: 171.4 bits (433), Expect = 4.959e-50 Identity = 119/297 (40.07%), Postives = 156/297 (52.53%), Query Frame = 2
Query: 182 EEWELFKTKFHKQYEPLTEAARRI-IWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNP-------------KGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT-VTSNVHNIT--VLVVGYGS-LFGSNYWIVKNSWA 994
EEW FK + K Y+ TE R+ I+ N I +HN + GK S+ L +N Y+D+ EF+ MNG N KG FI ++ LP SVDWRTKG V VKDQ +CGSCWAFS+TGALEGQH RK+G L+SLSEQ LVDC+ GN GC GGL AF Y++ + ++ EK Y Y A C +NK V A +T+I + E + T P D S + + V+ + N+ VLVVG+G+ G +YW+VKNSW
Sbjct: 27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFR-----QLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAID------ASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 311 HSP 2 Score: 59.6918 bits (143), Expect = 1.045e-9 Identity = 34/102 (33.33%), Postives = 53/102 (51.96%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ +A AVAT+GP+SVAID S F+FY G+Y++ Q N L + + G +WG+ +I M ++ Q GIAS + YP++
Sbjct: 240 QGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593) HSP 1 Score: 171.785 bits (434), Expect = 6.073e-50 Identity = 119/297 (40.07%), Postives = 155/297 (52.19%), Query Frame = 2
Query: 182 EEWELFKTKFHKQYEPLTEAARRI-IWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNP-------------KGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT-VTSNVHNIT--VLVVGYGS-LFGSNYWIVKNSWA 994
EEW FK + K Y+ TE R+ I+ N I +HN + GK S+ L +N Y+D+ EF+ MNG N KG FI ++ LP SVDWRTKG V VKDQ +CGSCWAFS+TGALEGQH RK+G L+SLSEQ LVDC+ GN GC GGL AF Y+ + ++ EK Y Y A C +NK V A +T+I + E + T P D S + + V+ + N+ VLVVG+G+ G +YW+VKNSW
Sbjct: 57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFR-----QLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAID------ASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 341 HSP 2 Score: 59.6918 bits (143), Expect = 1.271e-9 Identity = 34/102 (33.33%), Postives = 53/102 (51.96%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ +A AVAT+GP+SVAID S F+FY G+Y++ Q N L + + G +WG+ +I M ++ Q GIAS + YP++
Sbjct: 270 QGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955) HSP 1 Score: 160.999 bits (406), Expect = 4.513e-46 Identity = 114/286 (39.86%), Postives = 150/286 (52.45%), Query Frame = 2
Query: 215 KQYEPLTEAARRI-IWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNP-------------KGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT-VTSNVHNIT--VLVVGYGS-LFGSNYWIVKNSWA 994
K Y+ TE R+ I+ N I +HN + GK S+ L +N Y+D+ EF+ MNG N KG FI ++ LP SVDWRTKG V VKDQ +CGSCWAFS+TGALEGQH RK+G L+SLSEQ LVDC+ GN GC GGL AF Y++ + ++ EK Y Y A C +NK V A +T+I + E + T P D S + + V+ + N+ VLVVG+G+ G +YW+VKNSW
Sbjct: 35 KNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFR-----QLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAID------ASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 308 HSP 2 Score: 59.6918 bits (143), Expect = 1.031e-9 Identity = 34/102 (33.33%), Postives = 53/102 (51.96%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ +A AVAT+GP+SVAID S F+FY G+Y++ Q N L + + G +WG+ +I M ++ Q GIAS + YP++
Sbjct: 237 QGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021) HSP 1 Score: 142.51 bits (358), Expect = 4.420e-40 Identity = 92/213 (43.19%), Postives = 116/213 (54.46%), Query Frame = 2
Query: 410 KGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF-------TVTSNVHNIT--VLVVGYGS-LFGSNYWIVKNSWA 994
KG FI ++ LP SVDWRTKG V VKDQ +CGSCWAFS+TGALEGQH RK+G L+SLSEQ LVDC+ GN GC GGL AF Y+ + ++ EK Y Y A C +NK V A +T+I + E + T P +SVA + F + N+ VLVVG+G+ G +YW+VKNSW
Sbjct: 20 KGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGP------------VSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWG 219 HSP 2 Score: 60.077 bits (144), Expect = 4.686e-10 Identity = 34/102 (33.33%), Postives = 53/102 (51.96%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ +A AVAT+GP+SVAID S F+FY G+Y++ Q N L + + G +WG+ +I M ++ Q GIAS + YP++
Sbjct: 148 QGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG4847 (gene:FBgn0034229 transcript:FBtr0086934) HSP 1 Score: 126.331 bits (316), Expect = 1.083e-32 Identity = 94/286 (32.87%), Postives = 135/286 (47.20%), Query Frame = 2
Query: 239 AARRIIWEGNL----EFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLG-NRMNGSNPKGSEFIVTENIGA--LPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNF---GCIGGLPYQAFDYVEISE--MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWD-----RCL*LLMSVADVSDFIKMVFTVTSNVHNI----------TVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
AA R + EG + N + G H++ +N ++D+T +EF ++ G R + + + + N+ A +P + DWR G V VK Q CGSCWAF+ TGA+EG RKTG L +LSEQ LVDC P +F GC GG AF +++ + + E Y Y C Y+ SK A + I PP D + + L VA + ++ + ++N ++LVVGYGS G +YWIVKNSW GE G
Sbjct: 96 AADRALHEGAFASTKNLVEAGNAAFAQGVHTFKQAVNAFADLTHSEFLSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAFDWREHGGVTPVKFQGTCGSCWAFATTGAIEGHTFRKTGSLPNLSEQNLVDCG-PVEDFGLNGCDGGFQEAAFCFIDEVQKGVSQEGAYPYIDNKGTCKYDGSKSGATLQGFAAI------------PPKDEEQLKKVVATLGPVACSVNGLETLKNYAGGIYNDDECNKGEPNHSILVVGYGSEKGQDYWIVKNSWDDTWGEKG 368
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 213.386 bits (542), Expect = 3.844e-66 Identity = 125/319 (39.18%), Postives = 174/319 (54.55%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAK-KCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
M ++++L++ A+ A P +++ +L++ W +K++ K Y E RR+IWE NL I QHN EY LG H++ +G+N + D+T+ EF+ G + + + + A P VDWR +GYV VKDQ CGSCW+FS+TGALEGQ RKTGKLIS+SEQ LVDC+RP+GN GC GGL QAF YV E ++ E+ Y Y A C Y+ VA T + +I K L + + +V VS I TS + + VLVVGYG + G+ YWIVKNSW+
Sbjct: 1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELA----------LMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDH-AVLVVGYGYQGADVAGNRYWIVKNSWS 305 HSP 2 Score: 56.6102 bits (135), Expect = 1.519e-8 Identity = 35/106 (33.02%), Postives = 53/106 (50.00%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX---------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
KGN L AVA +GP+SVAID S + +FY++GIY +R+ ++ + + + WG+ YI M+KD N GIA+ A YP++
Sbjct: 232 KGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIY--YERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: si:dkey-239j18.2 (si:dkey-239j18.2 [Source:ZFIN;Acc:ZDB-GENE-121214-52]) HSP 1 Score: 213.386 bits (542), Expect = 3.844e-66 Identity = 125/319 (39.18%), Postives = 174/319 (54.55%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAK-KCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
M ++++L++ A+ A P +++ +L++ W +K++ K Y E RR+IWE NL I QHN EY LG H++ +G+N + D+T+ EF+ G + + + + A P VDWR +GYV VKDQ CGSCW+FS+TGALEGQ RKTGKLIS+SEQ LVDC+RP+GN GC GGL QAF YV E ++ E+ Y Y A C Y+ VA T + +I K L + + +V VS I TS + + VLVVGYG + G+ YWIVKNSW+
Sbjct: 1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKHDPNRTSQGPLFMEPKFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPHGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPKGNELA----------LMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSQLDH-AVLVVGYGYQGADVAGNRYWIVKNSWS 305 HSP 2 Score: 56.6102 bits (135), Expect = 1.519e-8 Identity = 35/106 (33.02%), Postives = 53/106 (50.00%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX---------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
KGN L AVA +GP+SVAID S + +FY++GIY +R+ ++ + + + WG+ YI M+KD N GIA+ A YP++
Sbjct: 232 KGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIY--YERACTSQLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctslb (cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285]) HSP 1 Score: 209.149 bits (531), Expect = 1.573e-64 Identity = 122/319 (38.24%), Postives = 171/319 (53.61%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAK-KCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
M ++++L++ A+ A P +++ +L++ W +K++ K Y E RR+IWE NL I QHN EY G H++ +G+N + D+T+ EF+ G + + + + A P VDWR +GYV VKDQ CGSCW+FS+TGALEGQ RKTGKLIS+SEQ LVDC+RP GN GC GGL QAF YV E ++ E+ Y Y A C Y+ VA T + +I L + + +V VS I +S+ + VLVVGYG + G+ YWIVKNSW+
Sbjct: 1 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYTHDPNQTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNELA----------LMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWS 306 HSP 2 Score: 54.299 bits (129), Expect = 9.444e-8 Identity = 34/105 (32.38%), Postives = 52/105 (49.52%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX---------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
GN L AVA +GP+SVAID S + +FY++GIY + S +R + + + WG+ YI M+KD N G+A++A YP++
Sbjct: 233 GNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSS-SRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKASYPLM 336
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctslb (cathepsin Lb [Source:ZFIN;Acc:ZDB-GENE-980526-285]) HSP 1 Score: 209.534 bits (532), Expect = 2.073e-64 Identity = 122/319 (38.24%), Postives = 171/319 (53.61%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAK-KCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
M ++++L++ A+ A P +++ +L++ W +K++ K Y E RR+IWE NL I QHN EY G H++ +G+N + D+T+ EF+ G + + + + A P VDWR +GYV VKDQ CGSCW+FS+TGALEGQ RKTGKLIS+SEQ LVDC+RP GN GC GGL QAF YV E ++ E+ Y Y A C Y+ VA T + +I L + + +V VS I +S+ + VLVVGYG + G+ YWIVKNSW+
Sbjct: 17 MMFALLVTLYISAVFAAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSYGNHTFKMGMNQFGDMTNEEFRQAMNGYTHDPNQTSQGPLFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGLMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPSGNELA----------LMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSSSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWS 322 HSP 2 Score: 53.9138 bits (128), Expect = 1.111e-7 Identity = 34/105 (32.38%), Postives = 52/105 (49.52%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX---------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
GN L AVA +GP+SVAID S + +FY++GIY + S +R + + + WG+ YI M+KD N G+A++A YP++
Sbjct: 249 GNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACSS-SRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGVATKASYPLM 352
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: zgc:174855 (zgc:174855 [Source:ZFIN;Acc:ZDB-GENE-071004-74]) HSP 1 Score: 208.379 bits (529), Expect = 2.730e-64 Identity = 120/321 (37.38%), Postives = 171/321 (53.27%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAK-KCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVH----------------NITVLVVGYG----SLFGSNYWIVKNSWA 994
M ++++L + A+ P +++ +L++ W +K++ K Y E RR+IWE NL I QHN EY LG H++ +G+N + D+T+ EF+ G + + + + + A P VDWR +GYV VKDQ CGSCW+FS+TGALEGQ RKTGKLIS+SEQ LVDC+RP GN GC GG+ QAF YV E ++ E+ Y Y A C Y+ VA T + +I + L L+ +VA V + ++ + VLVVGYG + G+ YWIVKNSW+
Sbjct: 1 MMFALLITLCISAVFTAP---SIDIQLDDHWNSWKSQHGKSYHEDVEVGRRMIWEENLRKIEQHNFEYSLGNHTFKMGMNQFGDMTNEEFRQAMNGYKQDPNRTSKGALFMEPSFFAAPQQVDWRQRGYVTPVKDQKQCGSCWSFSSTGALEGQLFRKTGKLISMSEQNLVDCSRPQGNQGCNGGIMDQAFQYVKENKGLDSEQSYPYLARDDLPCRYDPRFNVAKITGFVDIPRGNELA-------------LMNAVAAVGPVSVAIDASHQSLQFYQSGIYYERACTSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWS 305 HSP 2 Score: 56.9954 bits (136), Expect = 1.137e-8 Identity = 35/106 (33.02%), Postives = 53/106 (50.00%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX---------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+GN L AVA +GP+SVAID S + +FY++GIY +R+ +R + + + WG+ YI M+KD N GIA+ A YP++
Sbjct: 232 RGNELALMNAVAAVGPVSVAIDASHQSLQFYQSGIY--YERACTSRLDHAVLVVGYGYQGADVAGNRYWIVKNSWSDKWGDKGYIYMAKDKNNHCGIATMASYPLM 335
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 207.608 bits (527), Expect = 7.985e-64 Identity = 129/318 (40.57%), Postives = 170/318 (53.46%), Query Frame = 2
Query: 113 ILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT-----------------VTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQ 997
I ++ L + A P T + L+ W L+K K Y P E RR++WE NL I HNLE+ LGKHS++LG+N + D+T+ EF+ + + N +GS F+ N + P SVDWR KGYV VKDQ CGSCWAFS TGALEGQH R TGK+ISLSEQ LVDC+R GN GC GGL QAF YV + ++ E Y Y A + ++C Y+ + AN T + ++ + L+ +VA V V +S + VLVVGYG G YWIVKNSW++
Sbjct: 7 IAAICLTTVFAAP---TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFR-QLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKD-------------LMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSE 306 HSP 2 Score: 57.7658 bits (138), Expect = 9.674e-9 Identity = 35/104 (33.65%), Postives = 54/104 (51.92%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ DL AVA++GP+SVA+D + F+FYK+GIY + + S + L + D + WGN YI ++KD + GIA+ A YP++
Sbjct: 232 GSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272]) HSP 1 Score: 207.223 bits (526), Expect = 1.810e-63 Identity = 129/318 (40.57%), Postives = 170/318 (53.46%), Query Frame = 2
Query: 113 ILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT-----------------VTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQ 997
I ++ L + A P T + L+ W L+K K Y P E RR++WE NL I HNLE+ LGKHS++LG+N + D+T+ EF+ + + N +GS F+ N + P SVDWR KGYV VKDQ CGSCWAFS TGALEGQH R TGK+ISLSEQ LVDC+R GN GC GGL QAF YV + ++ E Y Y A + ++C Y+ + AN T + ++ + L+ +VA V V +S + VLVVGYG G YWIVKNSW++
Sbjct: 14 IAAICLTTVFAAP---TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFR-QLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKD-------------LMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSE 313 HSP 2 Score: 57.3806 bits (137), Expect = 1.090e-8 Identity = 35/104 (33.65%), Postives = 54/104 (51.92%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ DL AVA++GP+SVA+D + F+FYK+GIY + + S + L + D + WGN YI ++KD + GIA+ A YP++
Sbjct: 239 GSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ano1 (anoctamin 1, calcium activated chloride channel [Source:Xenbase;Acc:XB-GENE-5967576]) HSP 1 Score: 199.134 bits (505), Expect = 1.870e-60 Identity = 126/324 (38.89%), Postives = 173/324 (53.40%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEP-LTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENI---GALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMV----FTVTSNVH---------NITVLVVGYGSLFGSNYWIVKNSWA-QVGETG 1012
MK+ I L+ L AI + +N L+ W L+K +K YE + + RRI WE NL + HNLEY +G H+Y LG+N +D+T E K+K G + + + + F +N G +P S+DWR KG V VK+Q CGSCWAFSA GALEGQ + KTGKL+SLS Q LVDC+ GN GC GG QAF YV + ++ + +Y Y+A +KC Y+ + + YT I T D L S+ +S I F S V+ N VL VGYG+L G ++W++KNSW + G+ G
Sbjct: 1 MKSLIFLATVLAAI----VKARINPALDNHWLLWKNTHNKDYEDEIEDLQRRITWEKNLNLVNMHNLEYSMGMHTYELGMNHLADMTSEEIKSKLTGLILPPQSERQATFSSQKNSTFGGKVPDSIDWRDKGCVSDVKNQGGCGSCWAFSAVGALEGQLMLKTGKLVSLSPQNLVDCSSKYGNKGCGGGFMTQAFQYVIDNKGIDSDSYYPYHAMDEKCHYDPTGKASTCAKYTEIVPGTE----------DNLKQALGSIGPISVAIDGTRPSFFLYRSGVYSDPTCSHEVNHGVLAVGYGNLNGQDFWLLKNSWGTKYGDQG 310
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: harbi1 (harbinger transposase derived 1 [Source:Xenbase;Acc:XB-GENE-6077433]) HSP 1 Score: 187.193 bits (474), Expect = 7.221e-56 Identity = 112/293 (38.23%), Postives = 158/293 (53.92%), Query Frame = 2
Query: 167 NSELNEEWELFKTKFHKQYE-PLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMN-GSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK--ETILTWQPPWPPWDRCL*LLMSVA-DVSDFIKMVFTVTSNVH----------NITVLVVGYGSLFGSNYWIVKNSWAQ 997
N L+ EWE++KT +HK Y+ + E RR+IWE NL IR HNLE+ G H+Y LG+N + D+T E G +++ G P E +P+S+D+R KGYV ++DQ CGSCWAFS GALEGQ ++KTGKL+ +S Q LVDC + NFGC GG AF YV+ ++ ++ E+ Y Y +KC YN S A + +KK ET L + + L+ ++ + + F ++ N VL VGYG YWI+KNSW +
Sbjct: 21 NGTLDSEWEIWKTTYHKHYDNKIHELMRRLIWEKNLNIIRSHNLEFTQGLHTYELGMNKFGDMTSEEVVRMMTGLKVHTGMGPTNLTSDEDEASQRIPNSIDYRKKGYVTPIRDQGECGSCWAFSTVGALEGQLMKKTGKLVGISPQNLVDCVKD--NFGCGGGYMTTAFKYVKKNKGIDSEEAYPYVGMDQKCKYNVSGRAAEIKGFKEVKKGSETALK---------KAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGE 302 HSP 2 Score: 52.373 bits (124), Expect = 5.432e-7 Identity = 34/102 (33.33%), Postives = 48/102 (47.06%), Query Frame = 1
Query: 790 QKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+KG+ + L AV +GP+SV ID F YK GIY D + L + + + G WGN YILM+++ GIA+ A YPV+
Sbjct: 230 KKGSETALKKAVGLVGPISVGIDAGLDTFFLYKKGIYYDKSCDGDSINHAVLAVGYGKQKKGKYWIIKNSWGEDWGNKGYILMAREKGNACGIANLASYPVM 331
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: ctsk (cathepsin K (pycnodysostosis) [Source:NCBI gene;Acc:448216]) HSP 1 Score: 176.022 bits (445), Expect = 1.172e-51 Identity = 115/311 (36.98%), Postives = 162/311 (52.09%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYE-PLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTS---NVHNITVLVVGYGSLFGSNYWIVKNSWA 994
M F +LS L ++ G S L+ +WEL+K +H+QY L E RR IWE NL I QHN E+ G H+Y L +N D+T E K +G ++ ++ + +I N +P +D+R KGYV V +Q CGSCWAFS+ GALEGQ ++KTGKL+SLS Q LVDC+ N+GC GG AF YV + ++ + Y Y + + C YN + A Y I K + P + + S+ + K V+ +S + N VLVVGYG+ G +WI+KNSW
Sbjct: 1 MWWFSLLSFALSLVKIG---LCQESNLDSKWELWKKTYHRQYNGQLDEIRRRQIWEKNLNLISQHNKEFSQGLHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNHRPNNTYIPEWN-SRIPEYIDYRKKGYVTPVHNQGICGSCWAFSSVGALEGQLMKKTGKLVSLSPQNLVDCD--TDNYGCEGGYMTNAFGYVRDNGGIDSDAEYPYVGQDEGCHYNPADKAATCKGYKEIPVGSEKALKRAVANVGP------VSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWIIKNSWG 299 HSP 2 Score: 49.2914 bits (116), Expect = 4.872e-6 Identity = 33/110 (30.00%), Postives = 48/110 (43.64%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSD--------------LQRSQYNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ L AVA +GP+SV+ID S F+FYK G+Y D + W+ + G WG Y+L+++D GIAS A +PV+
Sbjct: 230 GSEKALKRAVANVGPVSVSIDASLPSFQFYKKGVYYDSSCNPDAVNHAVLVVGYGNEKGIKHWI----------IKNSWGDWWGKKGYVLLARDKKNACGIASLASFPVM 329
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452]) HSP 1 Score: 189.504 bits (480), Expect = 5.935e-57 Identity = 120/314 (38.22%), Postives = 159/314 (50.64%), Query Frame = 2
Query: 107 FIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENI-GALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIK------------MVF--TVTSNVHNITVLVVGYG-SLFGSNYWIVKNSWAQ 997
F++ +L L + A P N L+ WE +KTK K Y E +R +WE N + I HN +Y GKH ++L +N + D+T+ EF+ G G K + E + G +P SVDWR GYV VKDQ +CGSCWAFSA G+LEGQ RKTGKL+ LS Q LVDC+ GN GC GGLP AF YV + ++ Y Y A C YN A T + N++ D + + +V +S I M + +S V + VLVVGYG G YW+VKNSW +
Sbjct: 5 FLLATLCLGVVSAAPAH---NPSLDAVWEEWKTKHKKTYNMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTG--FQGQKTKMMMKVFQEPLLGDVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNVQSSE-----------DALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGR 302 HSP 2 Score: 56.6102 bits (135), Expect = 1.847e-8 Identity = 37/96 (38.54%), Postives = 47/96 (48.96%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXX-----XXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SV ID + F+FYK G+Y + S L + E + G WG YI M+KD N GIAS A YPV+
Sbjct: 236 LMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctss (cathepsin S [Source:MGI Symbol;Acc:MGI:107341]) HSP 1 Score: 186.037 bits (471), Expect = 1.563e-55 Identity = 125/308 (40.58%), Postives = 161/308 (52.27%), Query Frame = 2
Query: 131 VAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEA-ARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPN--GNFGCIGGLPYQAFDY-VEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
VA+E R T L+ W+L+K K+Y+ E RR+IWE NL+FI HNLEY +G H+Y +G+N D+T+ E + R+ +PK F N LP +VDWR KG V VK Q +CG+CWAFSA GALEGQ KTGKLISLS Q LVDC+ GN GC GG +AF Y ++ +E + Y Y A +KC YN A + Y + KE + T P +SV + F + T NV N VLVVGYG+L G +YW+VKNSW
Sbjct: 21 VAMEQLQRDPT----LDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNR-TLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGP------------VSVGIDASHSSFFFYKSGVYDDPSCTGNV-NHGVLVVGYGTLDGKDYWLVKNSWG 310
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsq (cathepsin Q [Source:MGI Symbol;Acc:MGI:2137385]) HSP 1 Score: 186.037 bits (471), Expect = 1.638e-55 Identity = 118/330 (35.76%), Postives = 163/330 (49.39%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPK--------GSEFIVTENI-GALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVH----------------NITVLVVGYGSLF----GSNYWIVKNSWAQ 997
M L + + I +G F + L+ EW+ + F K Y P E RR IWE N++ I+ HN E LGK++YT+GLNG++D+TD EF +G + N + GS F + ALP VDWR +GYV V++Q NC SCWAF TGA+EGQ +KTGKLI LS Q LVDC+RP GN GC G Y F YV +E + Y Y + C YN A T + + + + L+ +VA + V+S+ N VL++GYG + G+NYW++KNSW +
Sbjct: 1 MTPAFFLVILCLGILSGVSAF--DPSLDVEWKEWMGSFEKLYSPEEEVLRRAIWEENVKRIKLHNRENSLGKNTYTMGLNGFADMTDEEFMNIVIGATLPVDNTRKSLWKRALGSPFPKSWYWKDALPKFVDWRNEGYVTRVRNQRNCNSCWAFPVTGAIEGQMFKKTGKLIPLSVQNLVDCSRPQGNRGCRWGNTYNGFQYVLHNGGLEAQATYPYEGKEGLCRYNPKNSAAKITGFVVLPESEDV--------------LMDAVATKGPIATGIHVVSSSFRFYDGGVYYEPNCTSSVNHAVLIIGYGYVGNETDGNNYWLIKNSWGR 314
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctss (cathepsin S [Source:MGI Symbol;Acc:MGI:107341]) HSP 1 Score: 185.652 bits (470), Expect = 2.008e-55 Identity = 125/308 (40.58%), Postives = 161/308 (52.27%), Query Frame = 2
Query: 131 VAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEA-ARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPN--GNFGCIGGLPYQAFDY-VEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
VA+E R T L+ W+L+K K+Y+ E RR+IWE NL+FI HNLEY +G H+Y +G+N D+T+ E + R+ +PK F N LP +VDWR KG V VK Q +CG+CWAFSA GALEGQ KTGKLISLS Q LVDC+ GN GC GG +AF Y ++ +E + Y Y A +KC YN A + Y + KE + T P +SV + F + T NV N VLVVGYG+L G +YW+VKNSW
Sbjct: 22 VAMEQLQRDPT----LDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNR-TLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGP------------VSVGIDASHSSFFFYKSGVYDDPSCTGNV-NHGVLVVGYGTLDGKDYWLVKNSWG 311
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsj (cathepsin J [Source:MGI Symbol;Acc:MGI:1349426]) HSP 1 Score: 184.111 bits (466), Expect = 6.887e-55 Identity = 114/323 (35.29%), Postives = 164/323 (50.77%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAK----PLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYGS----LFGSNYWIVKNSWAQ 997
M ++L + + +G + + +L+ EW+ +KTK+ K Y P EA RR +WE N+ I+ HN E LGK+++T+ +N + D T EF+ P+ M ++P + +IG LP DWR +GYV V++Q CGSCWAF+A GA+EGQ KTG L LS Q L+DC++ GN GC G +QAF+YV ++ +E E Y Y + C Y AN T Y N+ + W + S+ VS I +S N VLVVGYGS G+NYW++KNSW +
Sbjct: 1 MTPTVLLLILCFGVASGAQAH--DPKLDAEWKDWKTKYAKSYSPKEEALRRAVWEENMRMIKLHNKENSLGKNNFTMKMNKFGDQTSEEFRKSIDNIPIPAAM--TDPHAQNHV---SIG-LPDYKDWREEGYVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCSKTVGNKGCQSGTAHQAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLPPNELYLWV-----------AVASIGPVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAVLVVGYGSEGDVKDGNNYWLIKNSWGE 304 HSP 2 Score: 52.373 bits (124), Expect = 4.310e-7 Identity = 35/97 (36.08%), Postives = 46/97 (47.42%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQY--NR------FSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYP 1077
L AVA++GP+S AID S FRFY GIY + S Y N + + + G WG Y+ ++KD+N GIAS A YP
Sbjct: 235 LWVAVASIGPVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAVLVVGYGSEGDVKDGNNYWLIKNSWGEEWGMNGYMQIAKDHNNHCGIASLASYP 331
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q24940|CATLL_FASHE (Cathepsin L-like proteinase OS=Fasciola hepatica OX=6192 GN=Cat-1 PE=1 SV=1) HSP 1 Score: 197.593 bits (501), Expect = 2.825e-59 Identity = 122/312 (39.10%), Postives = 168/312 (53.85%), Query Frame = 2
Query: 116 LSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSY------TNIKKETILTWQPPWPPWDRCL*LLMSVADVSDF------IKMVFTVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
+ LF++A+ V ++ W +K ++K+Y + RR IWE N++ I++HNL +DLG +YTLGLN ++D+T EFKAK L S+ N A+P +DWR GYV VKDQ NCGSCWAFS TG +EGQ+++ IS SEQQLVDC+ P GN GC GGL A+ Y++ +E E Y Y A +C YNK VA T Y + ++ + ++ + P ++V SDF I T + N VL VGYG+ G++YWIVKNSW GE G
Sbjct: 1 MRLFILAVLT----VGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRP---------AAVAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERG 299
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|O60911|CATL2_HUMAN (Cathepsin L2 OS=Homo sapiens OX=9606 GN=CTSV PE=1 SV=2) HSP 1 Score: 197.208 bits (500), Expect = 5.586e-59 Identity = 127/312 (40.71%), Postives = 171/312 (54.81%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVS-DFIK--MVFTVTSNVHNIT--VLVVGYG----SLFGSNYWIVKNSWA 994
M ++L+ F + I + +F N L+ +W +K + Y E RR +WE N++ I HN EY GKH +T+ +N + D+T+ EF+ + +G N KG F + LP SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTGKL+SLSEQ LVDC+RP GN GC GG +AF YV E ++ E+ Y Y A + C Y VAN T +T + K++ ++ P + + M S F K + F + N+ VLVVGYG + S YW+VKNSW
Sbjct: 1 MNLSLVLAAFCLGIASAVPKFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGP----ISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWG 304 HSP 2 Score: 59.3066 bits (142), Expect = 1.598e-8 Identity = 36/102 (35.29%), Postives = 50/102 (49.02%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRI--------TXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYP 1077
G L AVAT+GP+SVA+D F+FYK+GIY + S N L + + + GP WG+ Y+ ++KD N GIA+ A YP
Sbjct: 231 GKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2) HSP 1 Score: 196.438 bits (498), Expect = 1.033e-58 Identity = 125/320 (39.06%), Postives = 166/320 (51.88%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE------TILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG--SLFGSN--YWIVKNSWAQ 997
M +IL+ F + I + T + L +W +K ++ Y E RR +WE N++ I HN EY GKHS+T+ +N + D+T EF+ + N P+ + P SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTG+LISLSEQ LVDC+ P GN GC GGL AF YV+ + ++ E+ Y Y A + C YN VAN T + +I K+ + T P +SVA + +F +S + VLVVGYG S N YW+VKNSW +
Sbjct: 1 MNPTLILAAFCLGIASA--TLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGP------------ISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGE 304 HSP 2 Score: 56.9954 bits (136), Expect = 7.569e-8 Identity = 36/99 (36.36%), Postives = 46/99 (46.46%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SVAID F FYK GIY + S + L + + + G WG G Y+ M+KD GIAS A YP +
Sbjct: 235 LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1) HSP 1 Score: 196.052 bits (497), Expect = 1.350e-58 Identity = 124/320 (38.75%), Postives = 162/320 (50.62%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE------TILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQ 997
M IL+ + I + T N L +W +K ++ Y E RR +WE N++ I HN EY GKHS+T+ +N + D+T EF+ + N P+ + P SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTGKL+SLSEQ LVDC+ P GN GC GGL AF YV + ++ E+ Y Y A + C YN VAN T + +I K+ + T P +SVA + +F +S + VLVVGYG S YW+VKNSW +
Sbjct: 1 MNPTFILAALCLGIASA--TLTFNHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPKQEKALMKAVATVGP------------ISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGE 304 HSP 2 Score: 58.151 bits (139), Expect = 3.143e-8 Identity = 37/99 (37.37%), Postives = 46/99 (46.46%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SVAID F FYK GIY + S + L + + + G WG G YI M+KD GIAS A YP +
Sbjct: 235 LMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q28944|CATL1_PIG (Cathepsin L1 OS=Sus scrofa OX=9823 GN=CTSL PE=2 SV=1) HSP 1 Score: 189.119 bits (479), Expect = 6.612e-56 Identity = 123/323 (38.08%), Postives = 165/323 (51.08%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEF---IVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIKK------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
MK + L+ + I + + N L+ +W +K + Y E RR +WE N++ I HN EY GKH +++ +N + D+T+ EF+ + + N + KG F +V E +P SVDWR KGYV VK+Q CGSCWAFSATGALEGQ RKTGKL+SLSEQ LVDC+RP GN GC GGL AF YV + ++ E+ Y Y E C Y AN T + +I + + + T P +SVA + F +S + VLVVGYG S +WIVKNSW
Sbjct: 1 MKPSLFLTALCLGIASAAPKLDQN--LDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFR-QVMNGFQNQKHKKGKVFHESLVLE----VPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQREKALMKAVATVGP------------ISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWG 304 HSP 2 Score: 59.6918 bits (143), Expect = 1.195e-8 Identity = 37/99 (37.37%), Postives = 48/99 (48.48%), Query Frame = 1
Query: 811 LAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
L AVAT+GP+SVAID F+FYK+GIY D S + L + D GP WG Y+ M+KD N GI++ A YP +
Sbjct: 236 LMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYPTV 334
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1) HSP 1 Score: 293.508 bits (750), Expect = 3.598e-94 Identity = 160/313 (51.12%), Postives = 201/313 (64.22%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK--KETIL----TWQPPWPPWDRCL*LLMSVA-DVSDFIKMVFT--------VTSNVHNITVLVVGYGSLFGSNYWIVKNSW 991
MK ++ S+FLV I+A P +FT+NSELN+EWE++K KF K+YE L E +RRIIWE NL+FI+QHN+EYDLGKH+Y LGLN ++D+T EFKAK LG + N S FI+ ENIG LP+ +DWRTKGYV VK+Q CGSCWAFS TG+LEGQH RK+GKL+S SEQQLVDC+R N GC GGL AF Y++ +E E Y Y A C Y+K+K+V T + +IK ET L Q P +SVA D S+ + +S + VL +GYGS NYWIVKNSW
Sbjct: 1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYETLNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLGLKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKFGIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGP-----------ISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSW 302 HSP 2 Score: 66.2402 bits (160), Expect = 2.420e-8 Identity = 42/102 (41.18%), Postives = 56/102 (54.90%), Query Frame = 1
Query: 790 QKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXX----XXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+ GN +DL AAVAT GP+SVAID S+ F+FY+ GIY++ S + L I + + SWG YI MSKD Q GIA+ A YP++
Sbjct: 232 KTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1) HSP 1 Score: 246.128 bits (627), Expect = 1.429e-75 Identity = 141/313 (45.05%), Postives = 187/313 (59.74%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI--KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTV-TSNVH----------NITVLVVGYGSLFGSNYWIVKNSWA 994
MKA +++L LVA +FT+ ELNEEWE +K+ K YE E RR+IWE NL+ I++HNLEYD G HSYTLG+N + D+T EFKAK L + M + P+GS F+ N+G+LP VDWRTKGYV VKDQ CGSCWAFS TG+LEGQH +KTG L+SLSEQ LVDC+ GN GC GGL F Y++ ++ ++ E Y Y A +KC + S V A + + +I K E+ L + + + ++ D F + S V+ + VL VGYG+ G YW+VKNSW
Sbjct: 1 MKAAALIALCLVAAATAYPQFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYL-SPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESAL---------QQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWG 301 HSP 2 Score: 62.7734 bits (151), Expect = 3.609e-7 Identity = 38/99 (38.38%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 799 NNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
N S L AVAT+GP+SVAID F+ YK+G+YS+ S+ L + + G SWG YI+MS++ Q GIAS A YP++
Sbjct: 233 NESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1) HSP 1 Score: 245.743 bits (626), Expect = 1.955e-75 Identity = 141/313 (45.05%), Postives = 186/313 (59.42%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI--KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTV-TSNVH----------NITVLVVGYGSLFGSNYWIVKNSWA 994
MKA +++L LVA +FT+ ELNEEWE +K+ K YE E RR+IWE NL+ I++HNLEYD G HSYTLG+N + D+T EFKAK L + M + P+GS F+ N+G+LP VDWRTKGYV VKDQ CGSCWAFS TG+LEGQH +KTG L+SLSEQ LVDC+ GN GC GGL F Y++ ++ ++ E Y Y A +KC + S V A + + +I K E+ L + + ++ D F + S V+ + VL VGYG+ G YW+VKNSW
Sbjct: 1 MKAAALIALCLVAAATAYPQFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYL-SPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESAL---------QHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWG 301 HSP 2 Score: 62.7734 bits (151), Expect = 3.204e-7 Identity = 38/99 (38.38%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 799 NNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
N S L AVAT+GP+SVAID F+ YK+G+YS+ S+ L + + G SWG YI+MS++ Q GIAS A YP++
Sbjct: 233 NESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331
BLAST of Cathepsin L2 vs. TrEMBL
Match: I3SRD7 (Uncharacterized protein OS=Lotus japonicus OX=34305 PE=2 SV=1) HSP 1 Score: 245.743 bits (626), Expect = 2.339e-75 Identity = 143/312 (45.83%), Postives = 182/312 (58.33%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSE---FIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE-------TILTWQPPWPPWD---RCL*LLMSVADVSDFIKMVFTVTSNVHNITVLVVGYGSLFGSNYWIVKNSW 991
MKA + LF V + + P T N EL+ W LFKT F KQY E RR+ WE N+ IRQHNLE+DLG H+YTLGLN Y+D+T+AEF G R+N S K + ++ + LP+SVDWRTKGYV +KDQ CGSCWAFS+TG+LEGQH KTG+L+SLSEQ L DC++ GN GC GGL QAF Y+ E + ++ E Y Y A +KC + + V A T YT+I ++ I T P D L S A + + + T H VL VGY S G +Y+IVKNSW
Sbjct: 1 MKAIAAICLFFVCVYSAP---TFNVELDSHWALFKTTFGKQYSTAEEITRRLAWEANVAIIRQHNLEHDLGLHTYTLGLNNYADLTNAEFNQVMNGLRVNASQTKSANRRTYVAPVGV-ELPTSVDWRTKGYVTPIKDQGQCGSCWAFSSTGSLEGQHFAKTGQLVSLSEQNLTDCSQKQGNMGCNGGLMDQAFTYIKENNGIDTESSYPYKAVDEKCHFKAADVGATDTGYTDIAQQDENALQSAIATVGPISVAIDASHSSFQLYRSGA----YNERACSATQLDHG--VLAVGYDSEDGKDYYIVKNSW 302
BLAST of Cathepsin L2 vs. TrEMBL
Match: V4AF12 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_117223 PE=3 SV=1) HSP 1 Score: 231.106 bits (588), Expect = 6.652e-70 Identity = 123/288 (42.71%), Postives = 171/288 (59.38%), Query Frame = 2
Query: 179 NEEWELFKTKFHKQY--EPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF-----------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV 1000
+EEWE FK++ K Y + TE RR +WE NL+FI HN++ D G HSY LG+N D+T E G M +N G+ F+ N+G LP++VDWR +GYV +KDQ CGSCW+FSATG+LEGQH +KTG+L+SLSEQ LVDC+RP GN GC GGL QAF Y+++++ ++ E Y Y A KC +N++ V A +T+I + + Q + + + V+ D + F +S + VL VGYG+ GS+YW+VKNSW V
Sbjct: 12 DEEWEFFKSQHSKMYSDDSYTETYRRSVWEKNLQFINSHNMQADNGMHSYRLGMNHLGDMTREEINKMLNGYTMKTTNSTGATFMPPSNLGDLPTTVDWRKEGYVTPIKDQKQCGSCWSFSATGSLEGQHFKKTGQLVSLSEQNLVDCSRPEGNMGCAGGLMDQAFSYIKMNKGLDTEASYPYTARDGKCHFNRANVGATDVGFTDIPRFSEANLQ-------QAVATVGPVSVAIDASRSTFHFYKSGVYSDPECSSTRLDHGVLAVGYGTE-GSDYWLVKNSWGTV 291 HSP 2 Score: 65.855 bits (159), Expect = 3.230e-8 Identity = 39/97 (40.21%), Postives = 54/97 (55.67%), Query Frame = 1
Query: 802 NSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRI---TXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
++L AVAT+GP+SVAID S F FYK+G+YSD + S L + T + G WG YI+MS++ N Q GIA+ A YP++
Sbjct: 223 EANLQQAVATVGPVSVAIDASRSTFHFYKSGVYSDPECSSTRLDHGVLAVGYGTEGSDYWLVKNSWGTVWGMEGYIMMSRNKNNQCGIATSASYPLV 319
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700]) HSP 1 Score: 209.534 bits (532), Expect = 1.114e-64 Identity = 123/315 (39.05%), Postives = 176/315 (55.87%), Query Frame = 2
Query: 107 FIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQ 997
+ SL + G +++ +L++ W+L+K+ K Y E RR++WE NL+ + HNLE+ +GKH+Y LG+N ++D+T+ EF+ G R N + + + +P VDWR KGYV VKDQ CGSCWAFS+TGALEGQH RKTGKL+SLSEQ LVDC+RP GN GC GG+ QAF YV+ + ++ E+ Y Y A + + C Y+ + AN T + +I ++ ++ P +SVA + F +S + VLVVGYG G YWIVKNSW++
Sbjct: 3 LTLASLLALCFCTGFTAPSLDRQLDDHWKLWKSWHSKSYHEKEEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEPSFLEVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGP--------VSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSE 309 HSP 2 Score: 52.373 bits (124), Expect = 2.945e-7 Identity = 35/104 (33.65%), Postives = 46/104 (44.23%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G L AVA +GP+SVAID F+FY++GIY + S L + D + WG YI M+KD GIAS A YP++
Sbjct: 235 GEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106]) HSP 1 Score: 207.994 bits (528), Expect = 3.957e-64 Identity = 130/339 (38.35%), Postives = 175/339 (51.62%), Query Frame = 2
Query: 110 IILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIK--KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQVGETGDTFSCQKTTTSKVELL 1060
+ L+LF V + +++ +L++ WE +K K+Y E RR++WE NL+ I HNL++ LG H+Y LG+N + D+T EF+ G + + N P+ VDWR KGYV VKDQ CGSCWAFS TGA+EGQ RKTGKL+SLSEQ LVDC+RP GN GC GGL QAF Y+ + ++ E Y Y + + C Y+ AN T + +I KE L + + SV VS I +S + VLVVGYG + G YWIVKNSW++ DT + +T T V LL
Sbjct: 3 MYLALFAVCLSTVFAAPSLDRDLDDHWEQWKKWHSKKYHEKEEGWRRMVWEKNLKKIEMHNLDHSLGIHTYRLGMNHFGDMTHEEFRQIMNGYKHKKERKVRGSVFMEPNFLEAPAQVDWREKGYVTPVKDQGECGSCWAFSTTGAMEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYIKDQGGLDTEDSYPYLGTDDQPCHYDPQNSAANDTGFVDITSGKEHAL------------MKAVASVGPVSVAIDAGHESFQFYQSGIYYEKDCSSEELDHGVLVVGYGFQGEDVDGKKYWIVKNSWSENWGDKDTSTWPRTDTITVVLL 329
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106]) HSP 1 Score: 198.364 bits (503), Expect = 9.505e-61 Identity = 120/315 (38.10%), Postives = 166/315 (52.70%), Query Frame = 2
Query: 110 IILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQV 1000
+ L+LF V + +++ +L++ WE +K K+Y E RR++WE NL+ I HNL++ LG H+Y LG+N + D+T EF+ G + + N P+ VDWR KGYV VKDQ CGSCWAFS TGA+EGQ RKTGKL+SLSEQ LVDC+RP GN GC GGL QAF Y+ + ++ E Y Y + + C Y+ AN T + +I K+ ++ P +SVA + F +S + VLVVGYG + G YWIVKN + Q+
Sbjct: 3 MYLALFAVCLSTVFAAPSLDRDLDDHWEQWKKWHSKKYHEKEEGWRRMVWEKNLKKIEMHNLDHSLGIHTYRLGMNHFGDMTHEEFRQIMNGYKHKKERKVRGSVFMEPNFLEAPAQVDWREKGYVTPVKDQGECGSCWAFSTTGAMEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYIKDQGGLDTEDSYPYLGTDDQPCHYDPQNSAANDTGFVDITSGKEHALMKAVASVGP--------VSVAIDAGHESFQFYQSGIYYEKDCSSEELDHGVLVVGYGFQGEDVDGKKYWIVKNRYEQL 309
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:103044830]) HSP 1 Score: 191.43 bits (485), Expect = 7.447e-58 Identity = 123/309 (39.81%), Postives = 164/309 (53.07%), Query Frame = 2
Query: 110 IILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEP-LTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
++ LFL + G + L++ W+L+K K +K Y + E RR IWE NL+ I HNLE + H+Y L +N D+T E G R+ K S F+ + +P SVDWR KGYV VK Q CGSCWAFSA GALEGQ +R TG+L+SLS Q LVDC+ GN GC GG +AF YV + ++ + Y Y +C YN S AN TSY+ + +E + T P +SVA + + + + T NV N VLVVGYG+L G +YW+VKNSW
Sbjct: 1 MLRGLFLTLL-CGAAVALSDPNLDQHWQLWKKKHYKSYSTEVEEMGRREIWERNLQLISLHNLEASMDIHTYDLAMNHMGDLTREEILDMMAGTRVPSHLKKRSSFVSFAGV-QVPDSVDWREKGYVTNVKQQGACGSCWAFSAAGALEGQLMRTTGQLVSLSPQNLVDCSSKYGNKGCHGGFMSRAFQYVIDNGGIDSDASYPYNGMDGQCKYNPSDRAANCTSYSFLPEGNEEALKTAVATIGP--------VSVAIDATRPQFILYRSGVYYDPSCTKNV-NHGVLVVGYGTLNGEDYWLVKNSWG 298 HSP 2 Score: 51.9878 bits (123), Expect = 3.497e-7 Identity = 36/121 (29.75%), Postives = 55/121 (45.45%), Query Frame = 1
Query: 760 CRKFHFIY*YQKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQ-------------YNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
C + F+ +GN L AVAT+GP+SVAID + F Y++G+Y D ++ N WL + G +G+G YI M+++ GIAS YP++
Sbjct: 221 CTSYSFL---PEGNEEALKTAVATIGPVSVAIDATRPQFILYRSGVYYDPSCTKNVNHGVLVVGYGTLNGEDYWL----------VKNSWGTGFGDGGYIRMARNKGNMCGIASYCCYPIM 328
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924]) HSP 1 Score: 187.193 bits (474), Expect = 4.182e-56 Identity = 116/319 (36.36%), Postives = 166/319 (52.04%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKA---KPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVA-DVSDFIKMVFT--------VTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
M+ F+ ++ + + A +++ E + E+ +K K K Y P E+ R+I W N + + HN+ D G +Y LG+ ++D+ + E++ LG+ P S F+ LP++VDWRT+GYV VK+Q CGSCWAFSATGALEGQ RK G L+ LSEQQLVDC+R GN GC GG QAF YV + ++ E Y Y A C Y V A + Y +I +E + T P +SVA DV + ++ +++ VL VGYGS +G +YW+VKNSW
Sbjct: 1 MRVFLAVATLVAVVGAA----SISME-DLEFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGP------------VSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWG 302
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 204.527 bits (519), Expect = 1.660e-63 Identity = 133/320 (41.56%), Postives = 174/320 (54.37%), Query Frame = 2
Query: 110 IILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNP----KGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*L-LMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWA 994
++ +L V A P + L+EEW +K K YEP E+ RR+IWE NL I+ HNLE+ LGKH++ +G+N + D+T+ EF+ K N +G P KGS F+V +N A P +VDWR KG V VKDQ CGSCWAFS TGALEGQH+RK G+L+SLSEQ LVDC+R GN GC GGL QAF YV + ++ E Y Y + KC Y+ AN T + ++ ++ L + + SV VS I +S + VLVVGYG G YWIVKNSW+
Sbjct: 7 LVPALLAVMASATPIH---DPMLDEEWGSWKGFHQKLYEPKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQKM--NGYHGVQPHKVSKGSTFLVPQNYEA-PPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGD-----------EKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWS 309 HSP 2 Score: 55.4546 bits (132), Expect = 5.874e-9 Identity = 32/104 (30.77%), Postives = 51/104 (49.04%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ L AVA++GP+SVAID S F+FY++G+Y + S + L + P WG+ Y+LM+++ GIA+ A YP++
Sbjct: 236 GDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 192.2 bits (487), Expect = 3.215e-59 Identity = 114/270 (42.22%), Postives = 159/270 (58.89%), Query Frame = 2
Query: 236 EAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNR-MNGSN--PKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNI---KKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVHNI--TVLVVGYG-SLFGSNYWIVKNSWAQV-GETG 1012
E RRIIWE NL+ I HNLE+ +GKH++ +G+N +SD+T EF+ LG R NG++ P+G+ F+ A P SVDWR +GYV +K+Q +CGSCW+FS TG+LEGQH RKTG L+SLSEQ LVDC+ GN GC GGL AF+Y++ + ++ E+ Y Y + + C Y+ A T Y I +E ++ P + + S+A + ++ H+I VLVVGYG G +W+VKNSW GE G
Sbjct: 4 EGWRRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPAFFEA-PESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGP--VSVAIDASLASFQSYGSGIYKDAMCSHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQG 270
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 186.808 bits (473), Expect = 3.634e-57 Identity = 116/275 (42.18%), Postives = 160/275 (58.18%), Query Frame = 2
Query: 236 EAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNR-MNGSN--PKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEA-KKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--TVTSNVHNITVLVVGYG-SLFGSNYWIVKNSWA-QVGETG 1012
E RR+IWE NL+ I HNLE+ +GKH++ +G+N + D+T EF+ LG R NG++ P+G+ F+ A P SVDWR +GYV VK+Q +CGSCW+FS TG+LEGQH RKTG L+SLSEQ LVDC+ GN+GC GGL AF+Y++ + ++ E+ Y Y + + C YN A T Y I K + + P D L + +I ++ + S++ N VLVVGYG G +W+VKNSW Q GE G
Sbjct: 5 EGWRRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGFRGWNGTSKAPRGATFMAPAFFEA-PESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLY------YISGIYKDKLCSHIINHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKG 272
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 182.57 bits (462), Expect = 1.847e-55 Identity = 113/276 (40.94%), Postives = 155/276 (56.16%), Query Frame = 2
Query: 215 KQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSN-----PKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVHNIT--VLVVGYGSLFGS-NYWIVKNSWA 994
K Y+ E RR+IWE NL+ I HNLE+ +GKH++ +G+N + D+T EF+ LG R GSN +G+ F+ A P SVDWR +GYV VKDQ +CGSCWAFS TG+LEGQH RKTG L+SLSEQ LVDC+ GN GC GGL AF Y++ + ++ E Y Y A+ + C YN A T + +I K + + P + + S+ + +++ + +N+ VLVVGYG +WIVKNSW
Sbjct: 1 KTYDQNEEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLR--GSNDTSKASRGATFMAPAFFKA-PESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPV------SIGIDASLESFQLYSSGIYSDSDCSNNLDHGVLVVGYGVDDDERKFWIVKNSWG 267 HSP 2 Score: 56.9954 bits (136), Expect = 1.630e-9 Identity = 36/102 (35.29%), Postives = 53/102 (51.96%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX------XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
GN L AVA++GP+S+ ID S F+ Y +GIYSD S N + + + D + G WG+ YILM++D + GIA+ A YP++
Sbjct: 198 GNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCS--NNLDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008535.1 (pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 gene:ENSPMAG00000007699.1 transcript:ENSPMAT00000008535.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 176.022 bits (445), Expect = 2.242e-52 Identity = 100/247 (40.49%), Postives = 140/247 (56.68%), Query Frame = 2
Query: 77 NRIIFHNMKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPK-----GSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIKK 796
R ++ + A + LV A R + L+ WE + F K Y RR+IWE N+ F+ +HNLE+ LG HSYTLG+N +D+T EF+ G R GS + S F+ EN +P S+DWR +G V +K+Q CGSCWAFS+TGALEGQ R++G+L+ LSEQ L+DC+RP G GC GG AF YV + ++ E Y Y A + C Y+ S++VA + + +I K
Sbjct: 2 QRTVWSRVAAVFACLVALVGALAVSRP---DPALDGHWEAWTVYFKKAYTQTDGIKRRLIWEENMRFVDRHNLEHSLGLHSYTLGMNHLADLTVDEFRKTMNGYR-RGSRERHEGHHTSTFLAPENY-EVPQSMDWRDQGLVTPIKNQGQCGSCWAFSSTGALEGQWKRRSGELVPLSEQNLLDCSRPEGTEGCGGGWMDDAFQYVLDQGGIDSESDYPYTATDVDSCHYDPSRMVARISGFVDIHK 243
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5]) HSP 1 Score: 201.445 bits (511), Expect = 3.460e-62 Identity = 121/315 (38.41%), Postives = 173/315 (54.92%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFT--------------VTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQ 997
MKAF+ L V I + F+ S+ + +W +K K Y E RR IW NLE +++HN E HSY L +N ++D+T EFK + +G R ++ GS F+ N+ LP+ VDWR KG+V VK+Q CGSCWAFS+TG+LEGQH RKTGKL+SLSEQ LVDC++ GN GC GGL AF Y++ ++ ++ E+ Y Y A +C + V A T YT++++ + Q + +V +S I + +S + VL VGYG+ G +YW+VKNSW +
Sbjct: 1 MKAFLACLLVAVLI---AQCFSELSQ-DRQWHAWKDFHGKTYTGEEEDLRRAIWNDNLEIVKKHNAE----NHSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFLPLSNV-QLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSA----------VATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGE 296 HSP 2 Score: 66.6254 bits (161), Expect = 2.437e-12 Identity = 39/102 (38.24%), Postives = 55/102 (53.92%), Query Frame = 1
Query: 790 QKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXXGPSWGNG----RYILMSKDNNIQSGIASQAVYPVL 1083
Q+G+ DL +AVAT+GP+SVAID F+ YK G+YS+ S L + + SWG G YI MS++ + Q GIA+QA YP++
Sbjct: 224 QRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1]) HSP 1 Score: 191.43 bits (485), Expect = 3.371e-58 Identity = 124/318 (38.99%), Postives = 172/318 (54.09%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTE-AARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSN---PKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVA---NFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSNVHNIT----------VLVVGYGSLFGSNYWIVKNSWAQ 997
MK + L +F + + + W+LF TK +Y +TE AR+ IW NL+ I++HN E HS+TL +N D+T EF+ G R + SN +GS F+ ++ +P +VDWR +GYV VK+Q CGSCWAFS TG+LEGQ+ +KTGKL+SLSEQ LVDC+ GN GC GGL AF Y+ E ++ E+ Y Y A +C + KS + A F T+ +E + T P +SVA + + F S V+N VLVVGYG+ GS+YW+VKNSW +
Sbjct: 1 MKLLVAACLLFAVASGFVVKFDEDEQQWQAWKLFHTK---KYTTVTEEGARKAIWRDNLKKIQKHNAE----GHSFTLAMNHLGDLTQDEFRYFYTGMRSHYSNYTKKQGSAFLAPSHV-QVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGP--------ISVAIDAGHMSFQF-YHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGE 301 HSP 2 Score: 56.9954 bits (136), Expect = 3.147e-9 Identity = 35/110 (31.82%), Postives = 51/110 (46.36%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQ--------------YNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ L A T+GP+SVAID F+FY +G+Y++ S Y WL + G WG YI+MS++ N Q G+A+QA YP++
Sbjct: 231 GDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWL----------VKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6]) HSP 1 Score: 186.422 bits (472), Expect = 2.600e-56 Identity = 120/317 (37.85%), Postives = 171/317 (53.94%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRI-IWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPK--GSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVA-DVSDFIKMVFTVTSNVH------NITVLVVGYGSLFGSNYWIVKNSWA 994
MK F++L + + A R ++V + EW +K+ K Y + E R+ IW+ NLE I++HN E HSY + +N D+T+ EF+ LG R + ++ K + ++ N+ +PSSVDW KGYV VK+Q CGSCWAFS TG++EGQH RKTG L+SLSEQ L+DC+ GN GC GGL AF Y+E + ++ E Y Y + C ++ S V A T Y +I + + T P +SVA D S + V N + + VLV+GYG+ G +YW+VKNSW
Sbjct: 1 MKVFLVLCVLV----ASSRGWSVRFGQDSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAE----DHSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWATYMPPSNV-KIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGP------------VSVAVDASQWQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWG 296 HSP 2 Score: 55.8398 bits (133), Expect = 8.448e-9 Identity = 38/111 (34.23%), Postives = 56/111 (50.45%), Query Frame = 1
Query: 793 KGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSD--------------LQRSQYNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+G+ L +AVAT+GP+SVA+D S ++FY +G+Y + + YN WL + G SWG YI+MS++ N Q GIAS A YP++
Sbjct: 228 QGSEQALQSAVATVGPVSVAVDASQ--WQFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWL----------VKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9]) HSP 1 Score: 182.956 bits (463), Expect = 5.351e-55 Identity = 121/298 (40.60%), Postives = 156/298 (52.35%), Query Frame = 2
Query: 179 NEEWELFKTKFHKQYEPLTE-AARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNG---SNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL*LLMSVADVS---DFIKMVF-----------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
+ W+ +K+ K+Y E R IW+ NL+ I HN GKHS+ L +N D+T E LG ++ S PKG+ F+ N+ + S+DWR+KGYV VK+Q CGSCWAFS TGALEGQH RKTGKL+SLSEQ LVDC+ GN GC GGL AF Y+ E ++ EK Y Y A+ C YNKS + A T + +I Q L SV +S D + F +S + VL VGYG+ G +YW+VKNSW GE G
Sbjct: 26 DPNWKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHNE----GKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPANVKVV-DSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQ----------ALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEG 308 HSP 2 Score: 58.9214 bits (141), Expect = 7.539e-10 Identity = 31/100 (31.00%), Postives = 54/100 (54.00%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQ----RSQYNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ + L A+A++GP+S+AID S F FY G+Y D R + + + + GPSWG YI ++++++ + G+AS+A YP++
Sbjct: 232 GDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO42751 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0K3]) HSP 1 Score: 134.035 bits (336), Expect = 5.711e-37 Identity = 91/232 (39.22%), Postives = 126/232 (54.31%), Query Frame = 2
Query: 341 YSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTE-NIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVE-ISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE--TILTWQPPWPPWDRCL---*LLMSVADVSDFIKMVFTVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
+SD+++ EF+ + + M G E E +G +P SVDWR KG V VK+Q +CGSCWAFS TG +EGQ+ KTGKL+SLSEQ+LVDC+ + GC GGLP A+ +E + +E E Y Y KC +NK++V S I K+ I W P + + + ++ K+ +S H VL+VGYG G+ YWI+KNSW GE G
Sbjct: 29 FSDLSEEEFRKQKM---MPGWGKPLYEMKDAEIPLGDIPESVDWRDKGVVTPVKNQGSCGSCWAFSTTGNIEGQYAIKTGKLVSLSEQELVDCDTI--DKGCEGGLPSNAYKQIEKLGGLESESDYPYKGADSKCKFNKAEVKVTINSSVVISKDEKEIAAWLAKNGPISIGINANAMQFYMGGIAHPWKIFCNPSSLNHG--VLIVGYGVKNGTPYWIIKNSWGPSWGEKG 253
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246]) HSP 1 Score: 206.838 bits (525), Expect = 1.145e-63 Identity = 124/301 (41.20%), Postives = 161/301 (53.49%), Query Frame = 2
Query: 161 TVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYA-EAKKCIYNKSKVVANFTSYTNIK--KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF--------------TVTSNVHNITVLVVGYG----SLFGSNYWIVKNSWAQ 997
T++ +L++ W+L+K K Y E RR++WE NL I HNLE+ +GKHSY LG+N + D+T EF+ G + + N P +VDWR KGYV VKDQ CGSCWAFS TGALEGQ RKTGKL+SLSEQ LVDC+RP GN GC GGL QAF YV+ ++ ++ E Y Y + + C YN N T + +I KE L + + SV VS I +S+ + VLVVGYG + G YWIVKNSW++
Sbjct: 19 TLDPQLDQHWQLWKGWHSKNYHEKEEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEPNFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERAL------------MKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSE 307 HSP 2 Score: 50.8322 bits (120), Expect = 9.014e-7 Identity = 33/104 (31.73%), Postives = 50/104 (48.08%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXX--------GPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G L AVA++GP+SVAID F+FY++GIY + + S L + D + WG+ +I M+KD + GIA+ A YP++
Sbjct: 233 GKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789]) HSP 1 Score: 186.422 bits (472), Expect = 9.005e-56 Identity = 116/292 (39.73%), Postives = 155/292 (53.08%), Query Frame = 2
Query: 185 EWELFKTKFHKQYE-PLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFK---AKPLGNRMNGSNPK-GSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEIS-EMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
E+ ++ KF + Y P EA RR W N + + HN+ D G SY LG+ ++D+ + E+K ++ N S P+ GS F LP++VDWR KGYV VKDQ CGSCWAFSATG+LEGQ RKTGKL+SLSEQQLVDC+ GN GC GGL AF Y++ + ++ E+ Y Y AE +C Y V A T Y ++ +E + T P +SV + I +S+ + VL VGYGS G +YW+VKNSW
Sbjct: 30 EFHAWRLKFGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRGSTFFRLPENKDLPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGP------------ISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWG 309 HSP 2 Score: 56.9954 bits (136), Expect = 9.391e-9 Identity = 35/100 (35.00%), Postives = 52/100 (52.00%), Query Frame = 1
Query: 796 GNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
G+ L AVAT+GP+SV ID S F+ Y++G+Y + Q S L + + G +WG+ YI MSK+ + Q GIA+ A YP++
Sbjct: 240 GDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247]) HSP 1 Score: 175.637 bits (444), Expect = 9.143e-52 Identity = 120/300 (40.00%), Postives = 151/300 (50.33%), Query Frame = 2
Query: 161 TVNSELNEEWELFKTKFHKQY-EPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENI---GALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISE-MELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKET-------ILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQ 997
V S L++ W L+K + K Y + E RR IWE NLE I HNLE LG HSY L +N D+T E A G P G E I + + ++P SVDWR G V VK Q CGSCWAFSA GALEGQ + TG L SLS Q LVDC+ GN+GC GG AF YV ++ + + Y Y + KC Y+ AN T Y + K + T P +SVA + K +F + + NV N VLVVGYG+ G +YW+VKNSW +
Sbjct: 16 AVRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIASLTGTVA----PVGLERIHYDLVKINTSVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGP------------ISVAIDASRPKFLFYRHGVYKDHSCSHNV-NHGVLVVGYGTENGEDYWLVKNSWGE 298 HSP 2 Score: 56.225 bits (134), Expect = 1.825e-8 Identity = 38/112 (33.93%), Postives = 57/112 (50.89%), Query Frame = 1
Query: 760 CRKFHFIY*YQKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXXGPSW----GNGRYILMSKDNNIQSGIASQAVYPVL 1083
C ++F+ KG+ L VAT+GP+SVAID S F FY++G+Y D +N L + + + SW G+G YI M+++ Q GIA A +PV+
Sbjct: 220 CTGYNFL---PKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKD-HSCSHNVNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175]) HSP 1 Score: 174.481 bits (441), Expect = 4.006e-51 Identity = 117/303 (38.61%), Postives = 152/303 (50.17%), Query Frame = 2
Query: 167 NSELNEEWELFKTKFHKQYEPLTE-AARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSE--FIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYV-EISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK-------KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
+S L+ WEL+K K Y E RR +WE NL I HNLEY +G H+Y L +N D+T E + + +N K F+ +P +DWR K V VK Q +CGSCWAFSA GALEGQ RKTGKL+ LS Q LVDC+ GN GC GG +QAF YV + ++ + Y Y + C Y+ AN + Y+ + KE I T P +SVA + + F + + NV N VL VGYG+L G +YW+VKNSW GE G
Sbjct: 28 DSRLDIHWELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEI-LQQFASLRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGP------------ISVAIDATRPRFAFYRSGVYDDSSCSQNV-NHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQG 316 HSP 2 Score: 56.225 bits (134), Expect = 1.630e-8 Identity = 34/111 (30.63%), Postives = 57/111 (51.35%), Query Frame = 1
Query: 760 CRKFHFIY*YQKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQ---YNRFSRWLRITXXXXXXXXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
C ++ F+ +G+ L A+AT+GP+SVAID + F FY++G+Y D SQ + + + + G ++G YI M+++ N Q GIA YP++
Sbjct: 232 CSQYSFL---PEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSCSQNVNHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYPIM 339
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: cts12 (cathepsin L1-like [Source:NCBI gene;Acc:101170830]) HSP 1 Score: 171.4 bits (433), Expect = 3.169e-50 Identity = 110/318 (34.59%), Postives = 155/318 (48.74%), Query Frame = 2
Query: 116 LSLFLVAIEAGPRRFTVNSE--LNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVF---------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWAQV-GETG 1012
L+ L + P+ +S+ + EWE++K+ YE + RR IWE N I HN + GK +++G+N Y D+ E A+ L R N + VD+R GYV VKDQ CGSCWAFS TGA+EGQ ++KTG+L+SLSEQ LVDC+RP G GC G A+DYV + ++ Y Y ++ + C Y+ VA+ Y I + + + T P ++VA +D +F N + VL+VGYGS G +YWI+KNSW GE G
Sbjct: 11 LATLLYMLLCSPQHVRSDSDEAVLTEWEIWKSINGINYEERDDMQRRAIWEENHRMINDHNQRFLTGKRPFSMGMNKYGDLRGKEVSARRL--RYNARKSEAG-------------FVDYRNMGYVTEVKDQGYCGSCWAFSTTGAIEGQIVKKTGQLLSLSEQNLVDCSRPYGTHGCSGAWMASAYDYVLSNGLQTTDSYPYTSDTQPCFYDSRLAVAHIKDYRFIPQGDEQALADAVATIGP------------ITVAIDADHASFLFYSSGIYDEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGG 301 HSP 2 Score: 59.6918 bits (143), Expect = 1.329e-9 Identity = 39/112 (34.82%), Postives = 58/112 (51.79%), Query Frame = 1
Query: 763 RKFHFIY*YQKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXX-----XXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+ + FI +G+ LA AVAT+GP++VAID F FY +GIY D NR S + + + + G SWG G Y+ + ++ + GIAS A+YP+L
Sbjct: 217 KDYRFI---PQGDEQALADAVATIGPITVAIDADHASFLFYSSGIY-DEPNCDPNRLSHAVLLVGYGSEEGQDYWIIKNSWGSSWGEGGYMRIIRNGSNTCGIASYALYPIL 324
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014017.1 (SMESG000014017.1) HSP 1 Score: 499.204 bits (1284), Expect = 5.385e-180 Identity = 239/250 (95.60%), Postives = 242/250 (96.80%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL 847
MKAFIILSLFLVAIEAGPRRF VNSELNEEWELFK +FHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAK LGNRMNGSN KGSEF+V EN+GALPSSVDWRTKGYVI VKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCI GLPYQAFDYVEISEMELEKHYRYYAE KKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL
Sbjct: 1 MKAFIILSLFLVAIEAGPRRFPVNSELNEEWELFKAQFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKRLGNRMNGSNAKGSEFMVPENVGALPSSVDWRTKGYVIPVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIVGLPYQAFDYVEISEMELEKHYRYYAEDKKCIYNKSKVVANFTSYTNIKKETILTWQPPWPPWDRCL 250
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014171.1 (SMESG000014171.1) HSP 1 Score: 413.305 bits (1061), Expect = 9.226e-145 Identity = 219/313 (69.97%), Postives = 235/313 (75.08%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKK-------ETILTWQPPWPPWDRCL*LLMSV-ADVSDF------IKMVFTVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFK +FHKQYEPLTE RRIIWE NL+FIRQHNLEYDLGKHSYTLGLN YSD+T+AEFKAK LGNR+NGSN KGSEF+V ENIGALPSSVDWRTKGYV VK+Q CGSCWAFSATGALEGQH RKTGKLISLSEQQLVDC+RP GN GC GG PYQAFDYV ME E Y Y + KCIY+KSKVVANFTSYT K + T P L + + AD F I T +S + VLVVGYGSL G+NYWIVKNSW
Sbjct: 1 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLGNRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKPGNESDLAAAVATVGP----------LSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWG 303 HSP 2 Score: 78.1814 bits (191), Expect = 7.075e-16 Identity = 47/102 (46.08%), Postives = 59/102 (57.84%), Query Frame = 1
Query: 790 QKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXX----XXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+ GN SDLAAAVAT+GPLS+ ID F+ YKNGIY++ S L + + + GP WG YILMSKD + Q GIA+QAVYPV+
Sbjct: 232 KPGNESDLAAAVATVGPLSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWGPHWGIEGYILMSKDKDNQCGIATQAVYPVV 333
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000013991.1 (SMESG000013991.1) HSP 1 Score: 399.823 bits (1026), Expect = 1.549e-141 Identity = 192/201 (95.52%), Postives = 195/201 (97.01%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMEL 700
MKAFIILSLFLVAIEAGPRRF VNSELNEEWELFK +FHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAK LGNRMNGSNPKGSEF+V ENIGALPSSVDWRTKGYVILVKDQLNCGS WAFSATGALEGQ+ RKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMEL
Sbjct: 1 MKAFIILSLFLVAIEAGPRRFPVNSELNEEWELFKAQFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKLLGNRMNGSNPKGSEFMVPENIGALPSSVDWRTKGYVILVKDQLNCGSYWAFSATGALEGQYFRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMEL 201
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000013992.1 (SMESG000013992.1) HSP 1 Score: 399.823 bits (1026), Expect = 1.563e-139 Identity = 210/315 (66.67%), Postives = 229/315 (72.70%), Query Frame = 2
Query: 98 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIKKE-------TILTWQPPWPPWDRCL*LLMSVA-DVSDFIKMVF--------TVTSNVHNITVLVVGYGSLFGSNYWIVKNSWA 994
MKAFIILSLF VAIEAGPRRFTVNSELNEEWE+FK +FHKQYEP TE RRIIWE NLE IRQHNLEYDLGKHSYTLGLN YSD+T+ EFKAK LGNR+NGSNPKGSEF+V ENIGALPSSVDWRTKGYV VKDQ +CGSCWAFSATGALEGQ+ RKTGKLISLSEQQLVDC+RP GN C GG P++AFDYV E E Y Y + KCIY+KSKVVANFTSYT K+ + T P +SV D D+ + +S VLVVGYGSL G NYWIVKNSW
Sbjct: 1 MKAFIILSLFFVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPQTEVMRRIIWEENLELIRQHNLEYDLGKHSYTLGLNEYSDLTNEEFKAKRLGNRLNGSNPKGSEFMVPENIGALPSSVDWRTKGYVTPVKDQGDCGSCWAFSATGALEGQYFRKTGKLISLSEQQLVDCSRPYGNLACGGGFPHKAFDYVNKYGTESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKQRNESDLAAAVATVGP------------LSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWG 303 HSP 2 Score: 70.0922 bits (170), Expect = 3.077e-13 Identity = 46/99 (46.46%), Postives = 57/99 (57.58%), Query Frame = 1
Query: 799 NNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXXXXXXXXGPSWGN----GRYILMSKDNNIQSGIASQAVYPVL 1083
N SDLAAAVAT+GPLSV ID ++YKNGIY++ S L + D + SWG G YILMSKD + Q GIA++AVYPV+
Sbjct: 235 NESDLAAAVATVGPLSVGIDARDWRLQYYKNGIYNNPNCSSEYLGHYVLVVGYGSLNGDNYWIVKNSWGTDYGIGGYILMSKDKDNQCGIATRAVYPVV 333
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000013980.1 (SMESG000013980.1) HSP 1 Score: 387.111 bits (993), Expect = 7.108e-133 Identity = 208/323 (64.40%), Postives = 234/323 (72.45%), Query Frame = 2
Query: 53 QAYYKTQSNRIIFHNMKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARRIIWEGNLEFIRQHNLEYDLGKHSYTLGLNGYSDVTDAEFKAKPLGNRMNGSNPKGSEFIVTENIGALPSSVDWRTKGYVILVKDQLNCGSCWAFSATGALEGQHLRKTGKLISLSEQQLVDCNRPNGNFGCIGGLPYQAFDYVEISEMELEKHYRYYAEAKKCIYNKSKVVANFTSYTNIK---KETILTWQPPWPPWDRCL*LLMSVADVSDFIKMVFTVTSN------VHNITVLVVGYGSLFGSNYWIVKNSWA 994
+AYYK + AFIILSLFLVAIEAGPRRFTVNSELNEEWE+FK +FHKQYEPLTE RRIIWE NL+FIRQHNLEYDLGKH+YTLGLN YSD+T+AEFKAK LGNRMNGSN KGSEF+V ENIGALPSSVDWRTKGYV VK+Q +CGSCWAFSATGALEGQH RKTGKLISLSEQQLVDC+ P +GC G+P AF YVE +E E+ Y Y KKCIY+KSK VANFTS+T I+ + + P C+ AD F + +N N VL+VGYGSL G N+WIVKNSW
Sbjct: 106 RAYYKQICD-------DAFIILSLFLVAIEAGPRRFTVNSELNEEWEIFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHTYTLGLNEYSDLTNAEFKAKFLGNRMNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQGDCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSGP---YGCNLGIPVLAFYYVETYGIESEEDYPYCRAVKKCIYDKSKAVANFTSFTVIEPGNESDLAAAVATVGPVSVCI-----DADHPGFQHYKTGIYNNPKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWG 413 HSP 2 Score: 73.1738 bits (178), Expect = 5.903e-14 Identity = 45/103 (43.69%), Postives = 59/103 (57.28%), Query Frame = 1
Query: 790 QKGNNSDLAAAVATLGPLSVAIDVSSRCFRFYKNGIYSDLQRSQYNRFSRWLRITXXXXXX-----XXXXXXGPSWGNGRYILMSKDNNIQSGIASQAVYPVL 1083
+ GN SDLAAAVAT+GP+SV ID F+ YK GIY++ + + + + I + L + GP WG YILMSKD + Q GIAS A YPV+
Sbjct: 342 EPGNESDLAAAVATVGPVSVCIDADHPGFQHYKTGIYNN-PKCSFLCLNHAVLIVGYGSLNGDNFWIVKNSWGPDWGIEGYILMSKDKDNQCGIASLAAYPVV 443 The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30023018 ID=SMED30023018|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1084bpback to top protein sequence of SMED30023018-orf-1 >SMED30023018-orf-1 ID=SMED30023018-orf-1|Name=SMED30023018-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=251bp MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKTKFHKQYEPLTEAARback to top Annotated Terms
The following terms have been associated with this transcript:
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