WD_REPEATS_REGION domain-containing protein

Overview
NameWD_REPEATS_REGION domain-containing protein
Smed IDSMED30023002
Length (bp)2748
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of WD_REPEATS_REGION domain-containing protein (SMED30023002) t-SNE clustered cells

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30023002) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WD_REPEATS_REGION domain-containing protein (SMED30023002) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30023002) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30023002

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30023002h1SMcG0008532 SmedASXL_000571SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30023002h1SMcG0008532 SmedASXL_000571SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30023002h1SMcG0008532 dd_Smed_v4_16302_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30023002h1SMcG0008532 dd_Smed_v4_16302_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30023002h1SMcG0008532 SMED_37426_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30023002h1SMcG0008532 SMED_37426_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: LRWD1 (leucine rich repeats and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21769])

HSP 1 Score: 179.489 bits (454), Expect = 1.163e-46
Identity = 123/447 (27.52%), Postives = 219/447 (48.99%), Query Frame = 2 
Query: 1340 RPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQ--LDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI--EPGL--FINLLAAGGKSKEIRLFFSDRESFLD--LKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIW 2656
            +P  ++  + +PD + +S++ +K        R      +  + +   GS  +Q  +  +PLHF++CH+K+++P D ET++W CAF P+ +  G T+  VATCGGE VCVIDC  G V+++YK  GE+F ++AWT+L +  + G     ++LAA G    +RL    R  F    ++ H + +++L F P+    LF+      I +WDIG+P++       FQ    L      +   +  V     + L+AGC+     W +      +K R  ++E  F+E ++A         DGLA +    +  +        +  +      R G Q T+ +     L W  ++  Y ++S+  + G VL GD  G +W+YD+   +++ P  +       P ++L WP+    G     +    ++NTV  ++   ++  +TD+N+V IW
Sbjct:  224 KPRARLAALKRPDDVPLSLSPSK--------RACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEPAWE-EGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHV-RAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQD----YEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDV-RLDQPQKRRVCEVEFVFSEGSEA----SGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGR-GSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPP--LLPAALQAPTQILKWPQPWALGQVVTKT----MVNTVVANASFTYLTALTDSNIVAIW 644
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: LRWD1 (leucine rich repeats and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21769])

HSP 1 Score: 63.5438 bits (153), Expect = 2.026e-10
Identity = 59/251 (23.51%), Postives = 108/251 (43.03%), Query Frame = 2 
Query: 1925 IFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENP------EKVTNGFHCL-PCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIW 2656
            I +WDIG+P++       FQ    L      +   +  V     + L+AGC+     W +      +K R  ++E  F+E ++A         DGLA +    +  +        +  +      R G Q T+ +     L W  ++  Y ++S+  + G VL GD  G +W+YD+   +++ P      +  T     L P ++L WP+    G     +    ++NTV  ++   ++  +TD+N+V IW
Sbjct:    3 IILWDIGVPNQD----YEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDV-RLDQPQKRRVCEVEFVFSEGSEA----SGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGR-GSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQPSPPLSPHQILKWPQPWALGQVVTKT----MVNTVVANASFTYLTALTDSNIVAIW 239
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: LRWD1 (leucine rich repeats and WD repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21769])

HSP 1 Score: 51.6026 bits (122), Expect = 5.546e-7
Identity = 25/86 (29.07%), Postives = 49/86 (56.98%), Query Frame = 2 
Query: 1340 RPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPS 1597
            +P  ++  + +PD + +S++ +K        +  G       V  ++GS    +  +PLHF++CH+K+++P D ET++W CAF P+
Sbjct:   72 KPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGS-----PVAGSDGS-QPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEPA 151
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:327124])

HSP 1 Score: 168.318 bits (425), Expect = 1.157e-42
Identity = 109/392 (27.81%), Postives = 190/392 (48.47%), Query Frame = 2 
Query: 1511 PLHFIRCHAKDSAPNDQETKVWRCAFAP----STKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIE----PGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            PLH ++CH++ + P+D  T++W CAF P    S  + G +   +ATCGGE +CVI+C+ G V+ +YK  GEDF +LAW+++ +          N+LAAGGK   ++L       +F + +     +S + F+P  P  LF+G     IF+WDIG     Q    +   L+ L      L+  + L+     ++L++GCD+ ++ + +   K   K  E ++E+ F    K     +  + DGL+ +    +  +     + ++  +          +K +P      L W  +D  Y+++ +    G V+ GD  GR+W+Y +   + EN     +G       VL WP     G   + + + P IN+  M     ++V +TD N+V +WK
Sbjct:  385 PLHVLQCHSRQNDPDDFSTQLWACAFEPQQDDSIDISGGS-QTIATCGGETLCVINCESGLVLKKYKVPGEDFFSLAWSTVLMSRTGGSARPCNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKPTFLFTGTYDKKIFLWDIG--GLDQDYNFKISKLLTLETSSTPLH--LALLPSSPDTHLLSGCDEGLYCFDVQLSKNTLKRNE-EIEIVFPIYKKNDKKNNYRTIDGLSFLSDDVVASKSHMQGSIYLWSWSATRASWNSRKKEVPAVILAELQWSSTDIPYLSLGTCPGYGYVVCGDEQGRLWMYHITDTMMEN---FKSGKTISATEVLQWPSPIRAG---KGALEGPSINSTAMDPGLHYLVALTDKNMVVVWK 764

HSP 2 Score: 63.1586 bits (152), Expect = 1.276e-9
Identity = 59/216 (27.31%), Postives = 101/216 (46.76%), Query Frame = 2 
Query:  221 ATSLNEVFEIKLPGKSYTLINSTDL-----SRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSK 850
            +T  N++ +IK    S   + S DL     S+   L +LDLSGN+L +  + + LP LK+L+ S N+      +E   NL  L ++ N+ L +N +  V +  PNL++ NG+    T   H + +   ++  L   +   WE + +    D +      A+    V     +       LS Y    + K+ ++YL+S L  +E+E  V  T P+K
Sbjct:   19 STKTNKLDQIKTLNLSRMSLKSEDLPVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLTVNDEHKVIFLLPNLRMFNGKDISSTA--HHIRH--GSTEILRKRVIGVWERDFS--LPDPISAKSLAAVEKSFVNAACTQVKYGPNSLSDYTKWRVEKIAKEYLKS-LTSSEEEERVADTTPTK 227
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:327124])

HSP 1 Score: 168.318 bits (425), Expect = 1.179e-42
Identity = 109/392 (27.81%), Postives = 190/392 (48.47%), Query Frame = 2 
Query: 1511 PLHFIRCHAKDSAPNDQETKVWRCAFAP----STKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIE----PGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            PLH ++CH++ + P+D  T++W CAF P    S  + G +   +ATCGGE +CVI+C+ G V+ +YK  GEDF +LAW+++ +          N+LAAGGK   ++L       +F + +     +S + F+P  P  LF+G     IF+WDIG     Q    +   L+ L      L+  + L+     ++L++GCD+ ++ + +   K   K  E ++E+ F    K     +  + DGL+ +    +  +     + ++  +          +K +P      L W  +D  Y+++ +    G V+ GD  GR+W+Y +   + EN     +G       VL WP     G   + + + P IN+  M     ++V +TD N+V +WK
Sbjct:  380 PLHVLQCHSRQNDPDDFSTQLWACAFEPQQDDSIDISGGS-QTIATCGGETLCVINCESGLVLKKYKVPGEDFFSLAWSTVLMSRTGGSARPCNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKPTFLFTGTYDKKIFLWDIG--GLDQDYNFKISKLLTLETSSTPLH--LALLPSSPDTHLLSGCDEGLYCFDVQLSKNTLKRNE-EIEIVFPIYKKNDKKNNYRTIDGLSFLSDDVVASKSHMQGSIYLWSWSATRASWNSRKKEVPAVILAELQWSSTDIPYLSLGTCPGYGYVVCGDEQGRLWMYHITDTMMEN---FKSGKTISATEVLQWPSPIRAG---KGALEGPSINSTAMDPGLHYLVALTDKNMVVVWK 759

HSP 2 Score: 63.1586 bits (152), Expect = 1.178e-9
Identity = 59/216 (27.31%), Postives = 101/216 (46.76%), Query Frame = 2 
Query:  221 ATSLNEVFEIKLPGKSYTLINSTDL-----SRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSK 850
            +T  N++ +IK    S   + S DL     S+   L +LDLSGN+L +  + + LP LK+L+ S N+      +E   NL  L ++ N+ L +N +  V +  PNL++ NG+    T   H + +   ++  L   +   WE + +    D +      A+    V     +       LS Y    + K+ ++YL+S L  +E+E  V  T P+K
Sbjct:   14 STKTNKLDQIKTLNLSRMSLKSEDLPVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLTVNDEHKVIFLLPNLRMFNGKDISSTA--HHIRH--GSTEILRKRVIGVWERDFS--LPDPISAKSLAAVEKSFVNAACTQVKYGPNSLSDYTKWRVEKIAKEYLKS-LTSSEEEERVADTTPTK 222
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:100145159])

HSP 1 Score: 169.088 bits (427), Expect = 4.285e-43
Identity = 124/408 (30.39%), Postives = 194/408 (47.55%), Query Frame = 2 
Query: 1508 DPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI----EPGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPS-----------KHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKE--REPDMELRFTESNKAGIPIDSISYDGLAQIGRTAL-VFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCL----PCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            +PLHF++CH+K+++  D +T++W CAF P   +  ++   VATCGG+ VC+IDC+ GKV+ +YK  GE+F  L WT+L +    E    IN+LAAGGK   +R+  +     + ++K H + +S + F P     LF+G     I +WDIG+P               T+ V  +M +   CP                 +L+A C+D  FAW   D + DKK+  R  ++EL F    +     D    D LA +    + + R +    +  I   T+L R     K I        ++   +  Y   S       V  GD  G+IWIYDLD    +    +  G  C     P ++L WP   +  P ++    L  + TVD + +  ++V +TD N+V IWK+
Sbjct:  311 EPLHFLQCHSKNNSCEDFKTQLWACAFEPI--LDSSSPKAVATCGGDSVCIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDEQKRKINVLAAGGKHGVVRIIHAKVSLCYGEIKAHKKAISIMCFSPKQDTFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCLVPSCPD---------------EFLVAACEDGCFAW---DIRLDKKQGRRSYEVELNFPIYKEERKDNDFHVIDSLAFLNEDIIDMKRNMQKYIYIYIYIHTLLNRENANTKKIIKIIFTKKNFTSKEAPYPYRSQTRERYCVFCGDEDGKIWIYDLDSCKAD----LQRGKLCSVVKEPTKILSWPI--LFSPKEKVEKTLINVVTVDPTME--YLVALTDINIVSIWKI 690
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:100145159])

HSP 1 Score: 159.458 bits (402), Expect = 4.548e-40
Identity = 118/409 (28.85%), Postives = 185/409 (45.23%), Query Frame = 2 
Query: 1487 ISNQLD-YDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI----EPGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPS-----------KHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            I   LD  +PLHF++CH+K+++  D +T++W CAF P   +  ++   VATCGG+ VC+IDC+ GKV+ +YK  GE+F  L WT+L +    E    IN+LAAGGK   +R+  +     + ++K H + +S + F P     LF+G     I +WDIG+P               T+ V  +M +   CP                 +L+A C+D  FAW   D + DKK+       R+   N+    I  +   G   +  T +    +D     +  F + L                          +I  + R     V  GD  G+IWIYDLD    +            P ++L WP   +  P ++    L  + TVD + +  ++V +TD N+V IWK+
Sbjct:  303 IQKALDNIEPLHFLQCHSKNNSCEDFKTQLWACAFEPI--LDSSSPKAVATCGGDSVCIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDEQKRKINVLAAGGKHGVVRIIHAKVSLCYGEIKAHKKAISIMCFSPKQDTFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCLVPSCPD---------------EFLVAACEDGCFAW---DIRLDKKQGR-----RYIYINRRVQKISKV-VQGFVYLCHTCV---NLDAMLLALFKFKSTLMS------------------------FIFFTERY---CVFCGDEDGKIWIYDLDSCKADLQRGKLCSVVKEPTKILSWPI--LFSPKEKVEKTLINVVTVDPTME--YLVALTDINIVSIWKI 651
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:100145159])

HSP 1 Score: 142.51 bits (358), Expect = 1.854e-34
Identity = 80/232 (34.48%), Postives = 122/232 (52.59%), Query Frame = 2 
Query: 1487 ISNQLD-YDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI----EPGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPS-----------KHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKE 2131
            I   LD  +PLHF++CH+K+++  D +T++W CAF P   +  ++   VATCGG+ VC+IDC+ GKV+ +YK  GE+F  L WT+L +    E    IN+LAAGGK   +R+  +     + ++K H + +S + F P     LF+G     I +WDIG+P               T+ V  +M +   CP                 +L+A C+D  FAW   D + DKK+
Sbjct:  338 IQKALDNIEPLHFLQCHSKNNSCEDFKTQLWACAFEPI--LDSSSPKAVATCGGDSVCIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDEQKRKINVLAAGGKHGVVRIIHAKVSLCYGEIKAHKKAISIMCFSPKQDTFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCLVPSCPD---------------EFLVAACEDGCFAW---DIRLDKKQ 549
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:1918985])

HSP 1 Score: 190.274 bits (482), Expect = 1.541e-50
Identity = 134/475 (28.21%), Postives = 227/475 (47.79%), Query Frame = 2 
Query: 1268 LPKNHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGT--TTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI--EPGL--FINLLAAGGKSKEIRLFFSDRESFLD--LKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQ--MLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPE-CNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            +P  HP A   +   +   + KR          P  DP+        +PP  ++R           +    G  +  L  +PLHF++CH+++++P D ET++W CAF P+ +   +  T+  VATCGGE VCVIDC  G V+++YK  GE+F ++AWT+L +  + G     N+LAA G    +RL    R  F    ++ H + +++L F PS    LF+      I +WDIG+P++      +FQ   L+ L C    L         D   +L+AGC+   + W +      +K+R  ++   F+E +K    +     DGLA +    +  +       ++  +      R G Q  +P+     L W  ++  Y ++S+      VL GD  G +WIYD++  ++E P+  T      P ++L WP+   +G P  +      +INTV  ++   ++  +TD+N+V IW+
Sbjct:  212 VPVEHPQAAGASKFRAREVASKR----------PGKDPV-------TLPPSKRVRALPPAQAEGSPMGADGGQAA--LHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLRGMVRLLHV-RAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDIGVPNQD----YKFQASQLLTLNCGSVPLRLCPVATCPD--DFLLAGCEGGCYCWDV-RLDQPQKQRVCEVNFIFSEDSK----VSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGR-GRQSVLPVVILVRLQWSPTNLAYFSLSTCPGKNLVLCGDEEGSVWIYDVEHLLKEPPQATTLQ---PPTQILKWPQPTALGQPVTKT-----MINTVVANAAFTYLTALTDSNIVSIWR 646

HSP 2 Score: 51.2174 bits (121), Expect = 5.925e-6
Identity = 35/117 (29.91%), Postives = 56/117 (47.86%), Query Frame = 2 
Query:  293 LSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIA 640
            L R   LRELDLS NLL     ++ L +L++L  + N       + QFP L  L ++ N  L ++ +  V++  P L+ +NG+    T      + + N  R L   +   W+  IA
Sbjct:   43 LGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTC-----SQVENLDRELMDRVTAHWQKFIA 154
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Lrwd1 (leucine-rich repeats and WD repeat domain containing 1 [Source:MGI Symbol;Acc:MGI:1918985])

HSP 1 Score: 49.2914 bits (116), Expect = 6.668e-6
Identity = 35/117 (29.91%), Postives = 56/117 (47.86%), Query Frame = 2 
Query:  293 LSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIA 640
            L R   LRELDLS NLL     ++ L +L++L  + N       + QFP L  L ++ N  L ++ +  V++  P L+ +NG+    T      + + N  R L   +   W+  IA
Sbjct:   52 LGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTC-----SQVENLDRELMDRVTAHWQKFIA 163
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8BUI3|LRWD1_MOUSE (Leucine-rich repeat and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=LRWD1 PE=2 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 1.078e-49
Identity = 134/475 (28.21%), Postives = 227/475 (47.79%), Query Frame = 2 
Query: 1268 LPKNHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGT--TTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI--EPGL--FINLLAAGGKSKEIRLFFSDRESFLD--LKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQ--MLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPE-CNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            +P  HP A   +   +   + KR          P  DP+        +PP  ++R           +    G  +  L  +PLHF++CH+++++P D ET++W CAF P+ +   +  T+  VATCGGE VCVIDC  G V+++YK  GE+F ++AWT+L +  + G     N+LAA G    +RL    R  F    ++ H + +++L F PS    LF+      I +WDIG+P++      +FQ   L+ L C    L         D   +L+AGC+   + W +      +K+R  ++   F+E +K    +     DGLA +    +  +       ++  +      R G Q  +P+     L W  ++  Y ++S+      VL GD  G +WIYD++  ++E P+  T      P ++L WP+   +G P  +      +INTV  ++   ++  +TD+N+V IW+
Sbjct:  212 VPVEHPQAAGASKFRAREVASKR----------PGKDPV-------TLPPSKRVRALPPAQAEGSPMGADGGQAA--LHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLRGMVRLLHV-RAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDIGVPNQD----YKFQASQLLTLNCGSVPLRLCPVATCPD--DFLLAGCEGGCYCWDV-RLDQPQKQRVCEVNFIFSEDSK----VSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGR-GRQSVLPVVILVRLQWSPTNLAYFSLSTCPGKNLVLCGDEEGSVWIYDVEHLLKEPPQATTLQ---PPTQILKWPQPTALGQPVTKT-----MINTVVANAAFTYLTALTDSNIVSIWR 646
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|B0JZ65|LRWD1_XENTR (Leucine-rich repeat and WD repeat-containing protein 1 OS=Xenopus tropicalis OX=8364 GN=lrwd1 PE=2 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 2.020e-47
Identity = 127/416 (30.53%), Postives = 202/416 (48.56%), Query Frame = 2 
Query: 1487 ISNQLD-YDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI----EPGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPS-----------KHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKE--REPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQ-KTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCL----PCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            I   LD  +PLHF++CH+K+++  D +T++W CAF P   +  ++   VATCGG+ VC+IDC+ GKV+ +YK  GE+F  L WT+L +    E    IN+LAAGGK   +R+  +     + ++K H + +S + F P     LF+G     I +WDIG+P               T+ V  +M +   CP                 +L+A C+D  FAW   D + DKK+  R  ++EL F    +     D    D LA +    +  + V   + ++  +   L+ RK    K +       + W  S+  Y+ +S+      V  GD  G+IWIYDLD    +    +  G  C     P ++L WP   +  P ++    L  + TVD + +  ++V +TD N+V IWK+
Sbjct:  303 IQKALDNIEPLHFLQCHSKNNSCEDFKTQLWACAFEPI--LDSSSPKAVATCGGDSVCIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDEQKRKINVLAAGGKHGVVRIIHAKVSLCYGEIKAHKKAISIMCFSPKQDTFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCLVPSCPD---------------EFLVAACEDGCFAW---DIRLDKKQGRRSYEVELNFPIYKEERKDNDFHVIDSLAFLNEDIIASKSVMQGSIYLWSWEKTLKTRKTKNVKKLDAVILAQMKWSSSETPYLVLSTSPERYCVFCGDEDGKIWIYDLDSCKAD----LQRGKLCSVVKEPTKILSWP--ILFSPKEKVEKTLINVVTVDPTME--YLVALTDINIVSIWKI 690
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9UFC0|LRWD1_HUMAN (Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2)

HSP 1 Score: 177.948 bits (450), Expect = 1.628e-45
Identity = 123/447 (27.52%), Postives = 219/447 (48.99%), Query Frame = 2 
Query: 1340 RPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQ--LDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI--EPGL--FINLLAAGGKSKEIRLFFSDRESFLD--LKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIW 2656
            +P  ++  + +PD + +S++ +K        R      +  + +   GS  +Q  +  +PLHF++CH+K+++P D ET++W CAF P+ +  G T+  VATCGGE VCVIDC  G V+++YK  GE+F ++AWT+L +  + G     ++LAA G    +RL    R  F    ++ H + +++L F P+    LF+      I +WDIG+P++       FQ    L      +   +  V     + L+AGC+     W +      +K R  ++E  F+E ++A         DGLA +    +  +        +  +      R G Q T+ +     L W  ++  Y ++S+  + G VL GD  G +W+YD+   +++ P  +       P ++L WP+    G     +    ++NTV  ++   ++  +TD+N+V IW
Sbjct:  224 KPRARLAALKRPDDVPLSLSPSK--------RACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEPAWE-EGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHV-RAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDIGVPNQD----YEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDV-RLDQPQKRRVCEVEFVFSEGSEA----SGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGR-GSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPP--LLPAALQAPTQILKWPQPWALGQVVTKT----MVNTVVANASFTYLTALTDSNIVAIW 644
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6GM71|LRWD1_XENLA (Leucine-rich repeat and WD repeat-containing protein 1 OS=Xenopus laevis OX=8355 GN=lrwd1 PE=2 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 5.860e-45
Identity = 119/413 (28.81%), Postives = 194/413 (46.97%), Query Frame = 2 
Query: 1508 DPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI----EPGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPS-----------KHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFT-------ESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQ-KTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCL----PCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            +PLHF++CH+K+++  D +T++W CAF P+  +  +    VATCGG+ +C+IDC+ GKV+ +YK  GE+F  L WT+L +         IN+LAAGGK   +R+  +     + ++K H + +S + F P     LF+G     I +WDIG+P               T+ V  +M +   CP                 +L+A C+D  FAW   D   DKK+     E+ F          +K    IDS+++     +    +  + V   + ++  +   L+ RK    K +       + W  S+  Y+ +S+      V  GD  G+IWIYDLD    +    +  G  C     P ++L WP   +     E +    +IN V +     ++V +TD N+V IWK+
Sbjct:  341 EPLHFLQCHSKNNSCEDFKTQLWACAFEPN--LDSSCPKAVATCGGDSICIIDCETGKVMKKYKVTGEEFFTLVWTTLTMIGKDGQKRKINVLAAGGKYGVVRMIHAKGSLCYGEIKAHKKAISIMCFSPKQETFLFTGSYDKRIILWDIGVPDCDYNFRPSQLLTLDTTSVPLRMCVVPSCPD---------------EFLVAACEDGCFAW---DIGLDKKQGRRSHEVEFNFPLYKEERKDKCFHIIDSLAF-----LNEDIIASKSVMQGSIYLWSWEKTLKSRKNKNVKKLDAVILSQMKWSSSETPYLVLSTSPERDCVFCGDEDGKIWIYDLDSCKAD----LQRGKLCSTVKEPTKILSWP---LLCSQKEKTVDKTLINVVTVDPTMEYLVALTDINIVSIWKI 721
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|B0R160|LRWD1_DANRE (Leucine-rich repeat and WD repeat-containing protein 1 OS=Danio rerio OX=7955 GN=lrwd1 PE=1 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 8.900e-42
Identity = 109/392 (27.81%), Postives = 190/392 (48.47%), Query Frame = 2 
Query: 1511 PLHFIRCHAKDSAPNDQETKVWRCAFAP----STKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIE----PGLFINLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            PLH ++CH++ + P+D  T++W CAF P    S  + G +   +ATCGGE +CVI+C+ G V+ +YK  GEDF +LAW+++ +          N+LAAGGK   ++L       +F + +     +S + F+P  P  LF+G     IF+WDIG     Q    +   L+ L      L+  + L+     ++L++GCD+ ++ + +   K   K  E ++E+ F    K     +  + DGL+ +    +  +     + ++  +          +K +P      L W  +D  Y+++ +    G V+ GD  GR+W+Y +   + EN     +G       VL WP     G   + + + P IN+  M     ++V +TD N+V +WK
Sbjct:  380 PLHVLQCHSRQNDPDDFSTQLWACAFEPQQDDSIDISGGS-QTIATCGGETLCVINCESGLVLKKYKVPGEDFFSLAWSTVLMSRTGGSARPCNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKPTFLFTGTYDKKIFLWDIG--GLDQDYNFKISKLLTLETSSTPLH--LALLPSSPDTHLLSGCDEGLYCFDVQLSKNTLKRNE-EIEIVFPIYKKNDKKNNYRTIDGLSFLSDDVVASKSHMQGSIYLWSWSATRASWNSRKKEVPAVILAELQWSSTDIPYLSLGTCPGYGYVVCGDEQGRLWMYHITDTMMEN---FKSGKTISATEVLQWPSPIRAG---KGALEGPSINSTAMDPGLHYLVALTDKNMVVVWK 759

HSP 2 Score: 63.1586 bits (152), Expect = 8.892e-9
Identity = 59/216 (27.31%), Postives = 101/216 (46.76%), Query Frame = 2 
Query:  221 ATSLNEVFEIKLPGKSYTLINSTDL-----SRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSK 850
            +T  N++ +IK    S   + S DL     S+   L +LDLSGN+L +  + + LP LK+L+ S N+      +E   NL  L ++ N+ L +N +  V +  PNL++ NG+    T   H + +   ++  L   +   WE + +    D +      A+    V     +       LS Y    + K+ ++YL+S L  +E+E  V  T P+K
Sbjct:   14 STKTNKLDQIKTLNLSRMSLKSEDLPVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLTVNDEHKVIFLLPNLRMFNGKDISSTA--HHIRH--GSTEILRKRVIGVWERDFS--LPDPISAKSLAAVEKSFVNAACTQVKYGPNSLSDYTKWRVEKIAKEYLKS-LTSSEEEERVADTTPTK 222
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A0X3PR21 (Putative ATP-dependent RNA helicase DDX20 OS=Schistocephalus solidus OX=70667 GN=DDX20 PE=4 SV=1)

HSP 1 Score: 685.256 bits (1767), Expect = 0.000e+0
Identity = 400/965 (41.45%), Postives = 540/965 (55.96%), Query Frame = 2 
Query:  152 PIDMTXXXXXXXXXXXXXLYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRL---------QWFFTEIKDSER-------KDEELLKRFVNVYXXXXXXXXXXXR-----------NEIVGNNI---------ENANSQLILTTTDSGGNPQQFLIEQPG------SNIN-------FYQ-----SLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPDPIQISMANNKI---------------PP---------RPKMRRRN--------------------------GELRSLKDV-------------NKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSP---------KLPVINTVDMSSDGLFVVGVTDNNLVCIWKLA 2665
            P+D+ VEE D  +D  EIL IT A SL +V  +  P   YT IN+ DL+RC+NLRE+DLS N L  F R ++LPN+K LD++ N F   PL+EQFP L  L +D  MK  +N   +AYFCP LK ING+ FE    D  +     A   +E  IR+KWE+E A+RC+ +   + R  LI+ MV+QL+++N ++DE L  YR+LL ++  E+YL SK+Y  E       TI  +           + F  E  +S+         DE  ++     YE+DE     E R           +E++G N           N   Q+ L   + G   QQ L+  PG      S +N        YQ     SL Q + +VMTV   + + GRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQK  P+  P                 GRP K     P    +  S A + I               PP         RP+  +++                          G  RSL+D+             +    + +  +DYDPLHFIRCHAKD+   D ETKVWRC F P+   P  TTH VATCGGE VC+I+C+ GKV+ R+K   E+F  +AWT++E+E     N+LAA G+ +EIRL   ++   + ++KGH ED++++IFH + P ILFSGD+KAS+ VWDIG+PS       R+Q+LMRLRCPR D+NPV+NLVFL HY+YLIAGC+D +FAWKITD + +K+EREPDMEL+    ++  I       DGLAQ+   ALV +VV++    V DF  +LERRKGLQ+ +PIE  G L W ++D+ YIN+S R NLGAVL GD+ G IWIYDLDPY+++        F   P ++L+WPEC++ G  DE+           + PV+N+V+MSSDG F+  VTDNNLVCIW+ A
Sbjct:  523 PLDLVVEEEDIPLDASEILRITGAESLEKVTTLSAPCCGYTSINAFDLARCFNLREVDLSENALRVFPRRLHLPNMKRLDLTGNRFIHLPLIEQFPKLTRLTMDEKMKQLLNPQMLAYFCPRLKYINGQVFEEICSDFTIRIFQEARTIMEPHIRSKWESEFADRCHAVKSREERMRLIETMVQQLREKNFMLDESLGPYRNLLAYRFIEEYLRSKVYGPEGTAADGETIERRGARKIVELVSEEGFHLETDESDMLAEVARDSDETAIQAAGGHYEDDEEEKEAEARIAGERALFDAADELLGVNFPDLAFAGAQSNGQVQMTLLMDNFGRLHQQQLVPAPGGGYQLVSAVNGTQMGCPLYQLHLGRSLRQGRSIVMTVVRPRGISGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKTTPRKRP---------------GPGRPRKSDPQTPASKELPTSAAASMIPLSELNPSDLGSIKKPPNNAISTTVARPQNVKKSDRMMLDSGDGSAGAGLPPRPKKRKPPGMHRSLRDLCAEPPYGFTPSYLSSGLRTDATLIDYDPLHFIRCHAKDNDAGDSETKVWRCLFEPNPMRPEETTHIVATCGGECVCLINCETGKVMKRFKHMEEEFYTIAWTTVEVEGNKRTNILAAAGRMREIRLLHPEQLVCYAEMKGHTEDITAMIFHQTQPTILFSGDSKASVIVWDIGIPSVPDYK-TRYQLLMRLRCPRLDVNPVLNLVFLPHYAYLIAGCEDGLFAWKITDLRLEKREREPDMELKLEVDHEVCI-------DGLAQLSDNALVIKVVESGEIMVFDFAAVLERRKGLQRVVPIEMRGHLYWQKTDEIYINVSVRQNLGAVLCGDNEGAIWIYDLDPYLDDLHSSSRKKFFVKPIKILEWPECSVQGNRDEDQQLKESITSGFRNPVVNSVEMSSDGHFLAAVTDNNLVCIWRYA 1464
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A183MXP8 (WD_REPEATS_REGION domain-containing protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS20823 PE=4 SV=1)

HSP 1 Score: 669.078 bits (1725), Expect = 0.000e+0
Identity = 380/916 (41.48%), Postives = 532/916 (58.08%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDEELLKRFV---NVYXXXXXXXXXXXRNEIVGNNIEN----ANSQLILTTT---DSGG--NPQQFLIEQPGS-------------NINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPK--------------NHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPD-------------------PIQISM--------ANNKIPPRPKMRRRNGELRSLKDV--------NKANGSISNQ------------LDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSP---------KLPVINTVDMSSDGLFVVGVTDNNLVCIWKLA 2665
            L +TKA  L+ V  + +P   YT IN+ DL++C NLRELDLS N L  F R ++LP L  L I+ N F   PL EQFP LI L +D  +K  +N   + YFCP LK ING  FE  + D  +  I  A   +E IIR+KWE + A++   + + + R +LI+ M+  +K+RNLL+ E L+KY+DLL+F+  +++L S +Y+A D  L+   + S       T++++S                ++ + +  AL +  +E++G ++ +    A S   L TT   DS G  + QQ L+   G+              ++  +SL Q + +VMTV   + + GRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQK  PK              N    +     ++  ++   G  N ++G+   P                    P ++          A   +PPRPK R+  G  RSL+D+        +  N + +N             +DYDPLHFIRCHAKD+   D ETKVWRC F P+   P  TTH VATCGGE VC+I+C+ GKV+ R+K   E+F  +AWT++E+E     N+LAA G+  EIRL   ++   + ++KGH EDV+++IFH +   ILFSGD+KAS+ VWDIG+PS       R+Q+LMRLRCPR D+NPV+NLVFL HY+YLIAGC+D +FAWKITD + +K+EREPDMEL+   +++  I       D LAQ+   ALV +VV++    V DF +ILERRKGLQ+ +PIE  G L W ++D+ YIN+S R NLGAVL GD+ G IWIYDLDPY+++        FH  P +   WPEC++ G  DE+           + PV+N+V+MSSDG ++  VTDNNLVCIW+ A
Sbjct:  109 LCVTKARCLDRVRVLSVPASGYTSINTGDLAKCINLRELDLSENALRVFPRRLHLPQLTKLSITGNRFIHLPLFEQFPKLIRLNLDDKLKQLLNPQMLVYFCPKLKYINGIYFEEMLTDFTVRIIQEARSIMEPIIRSKWETDFADQYPFVKNREERMSLIENMMEHIKERNLLVGEALNKYKDLLLFRCIDEFLRSMIYDATDRELLHA-VNSLDTPKPITDVENSTDVTHTTTTTTDVTNKLFIKSDECALFDATDELLGTHLPDLQLLAQSANQLQTTFFVDSMGRLHQQQVLLTPNGACQLGLQTNGLSNYQLHLGRSLRQGRSIVMTVVRPRGISGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKTTPKKRTGTGKIRKSDQINTSTGERPWPGSTTSSTIPLGELNTEVGNTGAPTKRVTCTSNQMASSRTGSNRPSKVDFDVGEDTGGATGGLPPRPKKRKSMGMHRSLRDLCSDAPFSSDAYNNTTANTVVGGGPRSDATPIDYDPLHFIRCHAKDNDAGDSETKVWRCLFEPNPMRPDETTHVVATCGGECVCLINCETGKVMKRFKHMEEEFYTIAWTTVEVEGSKRTNILAAAGRMHEIRLLHPEQLVCYAEMKGHTEDVTAMIFHQTQSTILFSGDSKASVIVWDIGIPSVPDYK-TRYQLLMRLRCPRLDVNPVLNLVFLPHYAYLIAGCEDGLFAWKITDLRLEKREREPDMELKLDFNHEVCI-------DALAQLSDNALVLKVVESGEIMVFDFASILERRKGLQRVVPIEMRGHLLWQKTDEIYINVSVRQNLGAVLCGDNEGSIWIYDLDPYLDDLHSSSRKRFHVKPIK---WPECSVQGNRDEDQQLKESITSGFRNPVVNSVEMSSDGYYLAAVTDNNLVCIWRYA 1012
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: G4VCV9 (Putative dead box ATP-dependent RNA helicase OS=Schistosoma mansoni OX=6183 GN=Smp_171170 PE=4 SV=1)

HSP 1 Score: 654.44 bits (1687), Expect = 0.000e+0
Identity = 374/907 (41.23%), Postives = 523/907 (57.66%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDEELLKRFV---NVYXXXXXXXXXXXRNEIVGNNIEN----ANSQLILTTT---DSGG--NPQQFLIEQPGS-------------NINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPK--------------NHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPD-------------------PIQISM--------ANNKIPPRPKMRRRNGELRSLKDV--------NKANGSISNQ------------LDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKLA 2665
            L +TKA  L+ V  + +P   YT IN++DL++C NLRELDLS N L  F R ++LP L  L I+ N F   PL EQFP L+ L +D  +K  +N   + YFCP LK ING  FE  + D  +  I  A   +E IIR+KWE + A++   +   + R +LI+ M+  +K+RNLLI E L+KY+DLL+F+  +++L S +Y+A D  L+   + S       T+ ++S                ++ + +  AL +  +E++G ++ +    A S   L TT   DS G  + QQ L+   G+              ++  +SL Q + +VMTV   + + GRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQK  PK              N    + +   ++  ++   G  N ++G+   P                    P ++          A   +PPRPK R+  G  RSL+D+        +  N + +N             +DYDPLHFIRCHAKD+   D ETKVWRC F P+   P  TTH VATCGGE VC+I+C+ GKV+ R+K   E+F  +AWT++E+E     N+LAA G+  EIRL   ++   + ++KGH EDV+++IFH +   ILFSGD+KAS+ VWDIG+PS       R+Q+LMRLRCPR D+NPV+NLVFL HY+YLIAGC+D +FAWKITD + +K+EREPDMEL+   +++  I       D LAQ+   ALV +VV++    V DF +ILERRKGLQ+ +PIE  G L W ++D+ YIN+S R NLGAVL GD+ G IWIYDLDPY+++        FH  P +                  + PV+N+V+MSSDGL++  VTDNNLVCIW+ A
Sbjct:  157 LCVTKAKCLDRVRVLSVPASGYTSINTSDLAKCINLRELDLSENALRVFPRRLHLPQLTKLSITGNRFIHLPLFEQFPKLVRLNLDDKLKQLLNPQMLVYFCPKLKYINGIYFEEMLTDFTVRIIQEARSIMEPIIRSKWETDFADQYPFVKSREERMSLIENMMEHIKERNLLIGEALNKYKDLLLFRCIDEFLRSLIYDATDRELLHA-VNSLDTPKPITDAENSTNVTNTTTTTTDVTNELFVKSDECALFDAADELLGTHLPDLQLLAQSANQLQTTFFVDSMGRLHQQQVLLTPNGACQLGLQTNGLSNYQLHLGRSLRQGRSIVMTVVRPRGISGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKTTPKKRTGTGKIRKSDQINTSAGERSWPGSTTSSTIPLGELNTEVGNTGAPTKRVTCTSNQMASSRTGSNRPSKVDFDVGEDAGGATGGLPPRPKKRKSMGMHRSLRDLCSDAPFSSDAYNNTTANTVVGGGPRSDATPIDYDPLHFIRCHAKDNDAGDSETKVWRCLFEPNPMRPDETTHVVATCGGECVCLINCETGKVMKRFKHMEEEFYTIAWTTVEVEGSKRTNILAAAGRMHEIRLLHPEQLVCYAEMKGHTEDVTAMIFHQTQSTILFSGDSKASVIVWDIGIPSVPDYK-TRYQLLMRLRCPRLDVNPVLNLVFLPHYAYLIAGCEDGLFAWKITDLRLEKREREPDMELKLDFNHEVCI-------DALAQLSDNALVLKVVESGEIMVFDFASILERRKGLQRVVPIEMRGHLLWQKTDEIYINVSVRQNLGAVLCGDNEGSIWIYDLDPYLDDLHSSSRKRFHVKPIKGF----------------RNPVVNSVEMSSDGLYLAAVTDNNLVCIWRYA 1038
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A3R7D4E0 (Leucine-rich repeat and WD repeat-containing protein 1 (Fragment) OS=Clonorchis sinensis OX=79923 GN=lrwd1 PE=4 SV=1)

HSP 1 Score: 642.499 bits (1656), Expect = 0.000e+0
Identity = 376/941 (39.96%), Postives = 524/941 (55.69%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDN-------DH-------RRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKL----------------------YEAEDELLVPVT-----------IPSKRLQWFFTEIKDSERKDEELLKRFVNVYXXXXXXXXXXXRNEIVGNNIEN------ANSQLILT-TTDSGG--NPQQFLIEQPGSNIN-----------------FYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNH-------------PLAQXXXXXXXXXXXKKRGRPNKQIG--------DIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKD---------------VNKANG--SISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSP---------KLPVINTVDMSSDGLFVVGVTDNNLVCIWKLA 2665
            L +T+A+ L  V  + +P   YT IN+T L+RC NL ELDLS N L  F R ++LP L+ L ++ N F   PLVEQFP L  L +D  +K  +N   +AYFCP LK+ING+ FE    D  +  I  A   +E  +R+KWE + A+  + +          +H       R  L+DE + + KD  L++ + +  Y    +F  ++  L + +                      +  ED L  P             IPS+R      +I ++E   ++  +            AL E  +EI+G+N+ +      A  Q+  T   D+ G  + QQ L+   G   N                   +SL Q + +VMTV   + V GRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQK  PK               P +  +  N     + + G+ +  +         D   PD IQ   +   +PPRPK R+  G  RSL+D               VN   G  S +  +DYDPLHFIRCHAKD+   D ETKVWRC F P+ + P  TTH VATCGGE VC+I+C+ GKV+ R+K   E+F  +AWT++E+E G   N+LAA G+ +EIRL   ++   + ++KGH ED++++IFH + P ILFSGD+KAS+ VWDIG+PS       R+Q+LMRLRCPR D+NPV+NLVFL HY+YLIAGC+D +FAWK+TD + +K+EREPDMEL+    ++  I       D L+Q+   ALV +VV++    V DF ++LERRKGLQ+ +PIE  G L W ++D+ YIN+S R NLGAVL GD+ G IWIYDLDPY+++        FH  P ++L+WPEC++ G  DE+           + PV+N+V+MSSDG ++  VTDNNLVCIW+ A
Sbjct:  471 LRVTRASCLERVRILAVPACGYTSINATHLARCVNLLELDLSENALRVFPRRLHLPRLQRLGLTGNRFIHLPLVEQFPQLRRLTMDDKLKQLLNPQMLAYFCPKLKLINGQYFEELCTDFTVRIIQEARAIVEPHVRSKWEADFADHYHSVQSRAERMQLIEHIVQHLRERNLLVDESLNKYKD--LMLFQFVDSYLRSKLFDASDAELMTSVTTVGSKRDRIMTAHSATTDPTEFATEDLLAEPAVSDYETSPRSAPIPSQRPASMVVDI-ETEDNLDDDEEEREAEARAANERALFEATDEILGSNLPDPALLAGATGQVQTTLVMDAMGRLHQQQVLVAPAGYQTNGLLSGTMQTGGQSNQFHLARSLRQGRSIVMTVVRPRGVSGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKTTPKKRQGVNRPRKIDASWPCSPSSGMNPLGEVNTEGGKKSGSLASKSRHLKNDYDMPD-IQHQGSGTNLPPRPKKRKTMGGHRSLRDLCSESSYGTTDIYGTVNVGMGPRSDATPIDYDPLHFIRCHAKDNDAGDSETKVWRCLFEPNPQRPDETTHVVATCGGECVCLINCETGKVMKRFKHMEEEFYTIAWTTVEVECGKATNILAAAGRMREIRLLHPEQLVCYAEMKGHTEDITAMIFHQTQPTILFSGDSKASVLVWDIGIPSVPDYK-TRYQLLMRLRCPRLDVNPVLNLVFLPHYAYLIAGCEDGLFAWKVTDLRLEKREREPDMELKLDFDHEVCI-------DALSQLSDNALVIKVVESGEIMVFDFASVLERRKGLQRVVPIEMRGHLLWQKTDEIYINVSVRQNLGAVLCGDNEGSIWIYDLDPYLDDLHASSRKKFHVKPIKILEWPECSVQGNRDEDQQLKESITSGFRNPVVNSVEMSSDGYYLAAVTDNNLVCIWRYA 1399
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: G7Y5S2 (ATP-dependent RNA helicase DDX20 OS=Clonorchis sinensis OX=79923 GN=CLF_101446 PE=4 SV=1)

HSP 1 Score: 641.728 bits (1654), Expect = 0.000e+0
Identity = 376/941 (39.96%), Postives = 523/941 (55.58%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDN-------DH-------RRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKL----------------------YEAEDELLVPVT-----------IPSKRLQWFFTEIKDSERKDEELLKRFVNVYXXXXXXXXXXXRNEIVGNNI------ENANSQLILT-TTDSGG--NPQQFLIEQPGSNIN-----------------FYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNH-------------PLAQXXXXXXXXXXXKKRGRPNKQIG--------DIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKD---------------VNKANG--SISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSP---------KLPVINTVDMSSDGLFVVGVTDNNLVCIWKLA 2665
            L +T+A+ L  V  + +P   YT IN+T L+RC NL ELDLS N L  F R ++LP L+ L ++ N F   PLVEQFP L  L +D  +K  +N   +AYFCP LK+ING+ FE    D  +  I  A   +E  +R+KWE + A+  + +          +H       R  L+DE + + KD  L++ + +  Y    +F  ++  L + +                      +  ED L  P             IPS+R      +I ++E   ++  +            AL E  +EI+G+N+        A  Q+  T   D+ G  + QQ L+   G   N                   +SL Q + +VMTV   + V GRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQK  PK               P +  +  N     + + G+ +  +         D   PD IQ   +   +PPRPK R+  G  RSL+D               VN   G  S +  +DYDPLHFIRCHAKD+   D ETKVWRC F P+ + P  TTH VATCGGE VC+I+C+ GKV+ R+K   E+F  +AWT++E+E G   N+LAA G+ +EIRL   ++   + ++KGH ED++++IFH + P ILFSGD+KAS+ VWDIG+PS       R+Q+LMRLRCPR D+NPV+NLVFL HY+YLIAGC+D +FAWK+TD + +K+EREPDMEL+    ++  I       D L+Q+   ALV +VV++    V DF ++LERRKGLQ+ +PIE  G L W ++D+ YIN+S R NLGAVL GD+ G IWIYDLDPY+++        FH  P ++L+WPEC++ G  DE+           + PV+N+V+MSSDG ++  VTDNNLVCIW+ A
Sbjct:  301 LRVTRASCLERVRILAVPACGYTSINATHLARCVNLLELDLSENALRVFPRRLHLPRLQRLGLTGNRFIHLPLVEQFPQLRRLTMDDKLKQLLNPQMLAYFCPKLKLINGQYFEELCTDFTVRIIQEARAIVEPHVRSKWEADFADHYHSVQSRAERMQLIEHIVQHLRERNLLVDESLNKYKD--LMLFQFVDSYLRSKLFDASDAELMTSVTTVGSKRDRIMTAHSATTDPTEFATEDLLAEPAVSDYETSPRSAPIPSQRPASMVVDI-ETEDNLDDDEEEREAEARAANERALFEATDEILGSNLPDPALLAGATGQVQTTLVMDAMGRLHQQQVLVAPAGYQTNGLLSGTMQTGGQSNQFHLARSLRQGRSIVMTVVRPRGVSGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKTTPKKRQGVNRPRKIDASWPCSPSSGMNPLGEVNTEGGKKSGSLASKSRHLKNDYDMPD-IQHQGSGTNLPPRPKKRKTMGGHRSLRDLCSESSYGTTDIYGTVNVGMGPRSDATPIDYDPLHFIRCHAKDNDAGDSETKVWRCLFEPNPQRPDETTHVVATCGGECVCLINCETGKVMKRFKHMEEEFYTIAWTTVEVECGKATNILAAAGRMREIRLLHPEQLVCYAEMKGHTEDITAMIFHQTQPTILFSGDSKASVLVWDIGIPSVPDYK-TRYQLLMRLRCPRLDVNPVLNLVFLPHYAYLIAGCEDGLFAWKVTDLRLEKREREPDMELKLDFDHEVCI-------DALSQLSDNALVIKVVESGEIMVFDFASVLERRKGLQRVVPIEMRGHLLWQKTDEIYINVSVRQNLGAVLCGDNEGSIWIYDLDPYLDDLHASSRKKFHVKPIKILEWPECSVQGNRDEDQQLKESITSGFRNPVVNSVEMSSDGYYLAAVTDNNLVCIWRYA 1229
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: lrwd1 (leucine rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:103025579])

HSP 1 Score: 181.03 bits (458), Expect = 7.756e-47
Identity = 122/396 (30.81%), Postives = 199/396 (50.25%), Query Frame = 2 
Query: 1511 PLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTT--THFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEI--EPGLF--INLLAAGGKSKEIRLFFSDRE-SFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPE-CNIG-GPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKLAKD 2671
            PLH ++CH+K ++P+D  T++W CAF P       T     VATCGGE VCVIDC+ G V+ +YK  GE+F +LAWT+L +  E G     ++LAAGGK   ++L       ++ + +     +S+L F PS    LF+G     I +WDIG   +      +   L+ L      L+  + L+     ++LIAGCD  ++++ I   K  +K  E +ME+ F    K     +  + DGL+ +    +  +     + ++  +    +  KG +K +P      L W  +D  Y+++++    G ++ GD  GR+W Y +   ++ N     +G       VL+WP     G GP      K P IN+V M  D  ++V ++D N+V +WK AK+
Sbjct:  389 PLHVLQCHSKQNSPDDFSTQLWACAFEPVQNNGDATGWQQTVATCGGESVCVIDCESGHVLKKYKVPGEEFYSLAWTTLLMSREGGCARSCSILAAGGKRGIVKLIHPRVSMAYGEFRASRRAISALRFSPSHTSFLFTGAYDNKIVMWDIGGLDRDYH--FKTSQLLVLETGSTPLH--LCLLPSSPNTHLIAGCDSGLYSFDIQLSKNTQKRSE-EMEIVFPVYKKKDKSNEYRTIDGLSFLTDDIVASKSHMQGSIYLWSWSGTRDLWKGKKKEVPAVILAELQWSSTDIPYLSLNTCPGFGYIVCGDENGRLWTYHITDLMKAN---FKSGKVIPSTEVLEWPSPVRPGVGPV-----KGPSINSVAMDPDLHYLVALSDKNMVVVWKRAKN 771

HSP 2 Score: 60.4622 bits (145), Expect = 7.929e-9
Identity = 43/147 (29.25%), Postives = 76/147 (51.70%), Query Frame = 2 
Query:  218 KATSLNEVFEIKLPGKSYTLINSTDL-----SRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIA 640
            K + LN++  + L   S   + S DL     S+  +L +LDLSGN+L E  R ++LP+LK LD++ N+      ++   NL  L ++ N+ L +N +  V +  P L++ NG+    T   + + Y++  S  L   +   WE + +
Sbjct:   16 KTSQLNQIKSLNL---SRMGLKSQDLPLPLLSKLRSLEKLDLSGNMLQELPRGLSLPHLKSLDLTNNDMEDVTTLKALKNLEELRLEDNLYLTVNDEHKVLFLLPKLRMFNGKDISSTA--NHIRYVS--SEILRKRVIGVWEKDFS 155
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO47466 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM96])

HSP 1 Score: 152.91 bits (385), Expect = 1.052e-38
Identity = 114/414 (27.54%), Postives = 184/414 (44.44%), Query Frame = 2 
Query: 1460 KDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPG---LFINLLAAGGKSKEIRLFFSDRESFL-DLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFK-GDKKEREPDMELRFTESNKAGIPIDSIS--YDGLAQIGRT--ALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDL---DPYIEENPEK--VTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            KDV K   +      ++  H ++ H+ ++ P+D++T+VW C F P    PG TT   ATCGG+ VC IDC  G+V+ +YK+ GE F  +AW+++  +        NLLAAGG  + I++    +   + D+ G    + SL+FHP     L    A  +I +W+IG+PS       + ++L+ L+        V    F  H   ++  CDD  + WK+ D    + K R P   L F    K  +P+D +    D L    R     +       N    DF  +L+        +P        W +++  ++  S       +++GD  G +W+YD+    PY E+   K  V      L C            P D       V N V  ++   ++V V D N+VC+W+
Sbjct:  249 KDVKKRRHAYPADARFEVSHLLQTHSLNNNPDDRKTQVWGCQFEPDINNPGKTTSICATCGGDSVCFIDCSTGQVLKKYKQPGETFYCIAWSTVTADINGNKRKANLLAAGGSDRTIKIIEPTQLVCIEDIPGIKGVLESLLFHPCNSTWLGCA-ADDTITIWEIGLPSGLGYG-TKSKLLLTLK----SRTIVRFFAFAPHGMVVVGACDDGCYLWKLADMDPTNDKPRIPFGSLEF--PGKRSVPLDCVQCLSDSLIATKRVQEGSICIWHSESNMMKNDFSLVLK--------VP--------WRKTETPFLKFSFILECEVLVAGDDQGCVWLYDMMRFTPYTEKQSRKYEVMEQTQILLC------------PNDSTK----VFNQVCANTSLDYIVAVADTNVVCMWR 622

HSP 2 Score: 55.4546 bits (132), Expect = 9.212e-8
Identity = 51/208 (24.52%), Postives = 99/208 (47.60%), Query Frame = 2 
Query:  212 ITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFS-RSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDIL---DNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDE 820
            ++KA+ L+ +  + L G+  + I S  L +   + ELDLS N L +   + + LP+L  L+++ N  +       FPNL+ L + +N K+ ++    +   CP LK+++G+          ++ + +A   L++ + +K        C       D + +RA +D    +LK   +     L  YR+  +  L E+Y + K+ E + E
Sbjct:   18 VSKASDLSAIDTLSLQGQGLSQIESEILQQLTAIEELDLSNNKLVKLQLQDVFLPSLTKLNLANNQLATLEGFTAFPNLVDLNITNNPKIEVSEKYKLVAVCPLLKLLDGKD---------VSMMRDAVARLDSTLVSKVAEVWKSGCRTWTGKPDGEVKRAYLD----KLKAEVVCGPPMLKMYREFRLSVLGEEYYQ-KMLEGDTE 211
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: lrwd1 (leucine rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:101163993])

HSP 1 Score: 166.392 bits (420), Expect = 3.841e-42
Identity = 122/461 (26.46%), Postives = 212/461 (45.99%), Query Frame = 2 
Query: 1343 PNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKD------VNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPS--TKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFIN-----LLAAGGKSKEIRLFF-SDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDI-GMPSKHQTSLVRFQMLMRLRCP-RPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKIT-DFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFG-TILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHC----LPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            P +   D P+  P       N+  P+ +  +++G    L+       + K +  +   +   PLH ++CH+K  +  D  T++W CAF P+  +   G  +  VATCGG+ VCVIDC+ G V+ +YK  GE+F +LAW+++ +  G   +     +LAAGGK   ++L    +  ++ + +   + +S L FH      LF+G     I +WDI G+ S++   +V+   L     P    L P  N       + L+  C+D +F +          K R  DME+ F    K     +  + DG++ +    +  +   +   ++  +  T+ +R     + +       L W ++D  Y+ +++    G ++ GD  GRIW Y        N +K  NG+       P  VL+WP     G     S + P IN+V M  +  ++V ++D N+V IWK
Sbjct:  294 PTRGGKDAPRAKPKTHQSKANEAKPKERSGKQDGRASHLEKDCYTMPLFKTSSRMQQPVSLKPLHVLQCHSKQDSSEDFTTQLWACAFHPALDSSDSGGGSRLVATCGGDSVCVIDCETGMVMKKYKVPGEEFFSLAWSTVLMSRGSKASAQPCAVLAAGGKRGLVKLIHPRNNLAYGEFRASRKALSVLRFHRQKENFLFTGSYDNKIVMWDIGGIDSQYNFKVVQLLALESRTTPLHICLPPTSN-------NLLLVACEDGLFCYNTQLGTSSTTKSRSMDMEITFPIYEKEDEDHEYHTVDGMSFLNDDLVASKNYMHSCIYLWSWSRTVAQRPDRKSRKVCAVIVAELQWAKTDIPYLALNTCPGRGYIVCGDEKGRIWTYH-----AANLQK--NGYQTGKPIPPTDVLEWPAPRRKG---LGSLEGPSINSVAMDPELTYMVALSDKNMVIIWK 737

HSP 2 Score: 54.299 bits (129), Expect = 5.780e-7
Identity = 38/117 (32.48%), Postives = 55/117 (47.01%), Query Frame = 2 
Query:  293 LSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIA 640
            LSR  +L  LDLSGN L +F +++ LP L  LD+S N       +E    L  L +D N+ + ++ +  +    PNL+I NG+    T       Y  N    L T I   WE   +
Sbjct:   43 LSRLQSLERLDLSGNRLQKFPKNLKLPVLFFLDLSDNQMEDVTTLESLSTLEELKMDDNLYITVSDNYKLMVLLPNLRIFNGKDVSTTANHLRFVYSDN----LRTRIAAVWEKNFS 155
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: lrwd1 (leucine rich repeats and WD repeat domain containing 1 [Source:NCBI gene;Acc:101163993])

HSP 1 Score: 166.392 bits (420), Expect = 3.841e-42
Identity = 122/461 (26.46%), Postives = 212/461 (45.99%), Query Frame = 2 
Query: 1343 PNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKD------VNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPS--TKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFIN-----LLAAGGKSKEIRLFF-SDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDI-GMPSKHQTSLVRFQMLMRLRCP-RPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKIT-DFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFG-TILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHC----LPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWK 2659
            P +   D P+  P       N+  P+ +  +++G    L+       + K +  +   +   PLH ++CH+K  +  D  T++W CAF P+  +   G  +  VATCGG+ VCVIDC+ G V+ +YK  GE+F +LAW+++ +  G   +     +LAAGGK   ++L    +  ++ + +   + +S L FH      LF+G     I +WDI G+ S++   +V+   L     P    L P  N       + L+  C+D +F +          K R  DME+ F    K     +  + DG++ +    +  +   +   ++  +  T+ +R     + +       L W ++D  Y+ +++    G ++ GD  GRIW Y        N +K  NG+       P  VL+WP     G     S + P IN+V M  +  ++V ++D N+V IWK
Sbjct:  294 PTRGGKDAPRAKPKTHQSKANEAKPKERSGKQDGRASHLEKDCYTMPLFKTSSRMQQPVSLKPLHVLQCHSKQDSSEDFTTQLWACAFHPALDSSDSGGGSRLVATCGGDSVCVIDCETGMVMKKYKVPGEEFFSLAWSTVLMSRGSKASAQPCAVLAAGGKRGLVKLIHPRNNLAYGEFRASRKALSVLRFHRQKENFLFTGSYDNKIVMWDIGGIDSQYNFKVVQLLALESRTTPLHICLPPTSN-------NLLLVACEDGLFCYNTQLGTSSTTKSRSMDMEITFPIYEKEDEDHEYHTVDGMSFLNDDLVASKNYMHSCIYLWSWSRTVAQRPDRKSRKVCAVIVAELQWAKTDIPYLALNTCPGRGYIVCGDEKGRIWTYH-----AANLQK--NGYQTGKPIPPTDVLEWPAPRRKG---LGSLEGPSINSVAMDPELTYMVALSDKNMVIIWK 737

HSP 2 Score: 54.299 bits (129), Expect = 5.780e-7
Identity = 38/117 (32.48%), Postives = 55/117 (47.01%), Query Frame = 2 
Query:  293 LSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTD-AVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIA 640
            LSR  +L  LDLSGN L +F +++ LP L  LD+S N       +E    L  L +D N+ + ++ +  +    PNL+I NG+    T       Y  N    L T I   WE   +
Sbjct:   43 LSRLQSLERLDLSGNRLQKFPKNLKLPVLFFLDLSDNQMEDVTTLESLSTLEELKMDDNLYITVSDNYKLMVLLPNLRIFNGKDVSTTANHLRFVYSDN----LRTRIAAVWEKNFS 155
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000066671.1 (SMESG000066671.1)

HSP 1 Score: 1686.39 bits (4366), Expect = 0.000e+0
Identity = 856/860 (99.53%), Postives = 858/860 (99.77%), Query Frame = 2 
Query:  104 MWGNKYEPYFNKEKYIPIDMTXXXXXXXXXXXXXLYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDEELLKRFVNVYXXXXXXXXXXXRNEIVGNNIENANSQLILTTTDSGGNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNHPLAQXXXXXXXXXXXKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKLAKDEIPN 2683
            MWGNKYEPYFNKEKYIPIDMTVEEVDKIIDEEEILYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDEELLKRFVNVYEEDELAALLELRNE+VGNNIENANSQLILTTTDS GNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNHPLAQINNSNNSNINSKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRC FAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFIN+LAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKLAKDEIPN
Sbjct:    1 MWGNKYEPYFNKEKYIPIDMTVEEVDKIIDEEEILYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDEELLKRFVNVYEEDELAALLELRNEMVGNNIENANSQLILTTTDSDGNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNHPLAQINNSNNSNINSKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCGFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINILAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKLAKDEIPN 860
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000073045.1 (SMESG000073045.1)

HSP 1 Score: 950.658 bits (2456), Expect = 0.000e+0
Identity = 481/854 (56.32%), Postives = 624/854 (73.07%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDE-ELLKRFVNVYXXXXXXXXXXXRNEIVGNNIENANSQLILTTTDSGGNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPK-----------------NHPLAQXXXXXXXXXXXKKRGRPNKQIGDIP------KPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDE-------NSPKL--PVINTVDMSSDGLFVVGVTDNNLVCIWKLAK 2668
            L  + +T L+EV  +K+P  +YT+I S +L++C  LRELD S NLL+EF R +NLP LK L+++ N F Q+PL+EQFPNL+VL  D   K NMN  A+++FCP LK INGE FE  + ++F  YI  A  AL+ IIRNKWE+E A+RC +IL+N  R +LIDEMV+QLKDRNLLID++LSKY+DLLIFK TE+YL+SKL + EDELL       KR    +  I++ +  D+ +LL+RFV+V  ++E+  L EL +E++GNN +N  S ++L T    G  QQ++++QP    +  QSL QNK VVMTV   + VKGRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQKG PK                 N PL +I+NSN+ N   KKRGRP K I  +P      +    ++   +  +P RPK RR  G  RSL+D+ K +G  ++ +DYDPLHFIRCHAKD+AP DQ+TKVWRC F P+   P  TTH VATCGGE VC+IDC  GKV+ R+KRE E+F+ LAWT+LEIEPG  +N+LAA GK KEIRL F D   + D++GH ED+S+L+FHPS+PQILFSGD KAS+F+WDIG PS +Q+ L+R+Q+LMRLRCPR D+NPV+NLVFLDHYSYL+AGC+D +FAWKIT+++ +K+EREPDMEL+    +K  + +DSISYDGLAQ+ RTALVF++V N N  V DFGT LERRKGLQK +PI+ CGTL W +++DFYIN+++R NLGAVL GDS+G IWIYDLDP+IEE PE+++  F C P +VL+WPECN+ G   +        SP+L  PVINTVD+SSDGL+++ VTDNNLVCIW+L+K
Sbjct:  228 LKYSSSTKLDEVRVLKIPCNNYTVIESRNLAKCVRLRELDFSENLLSEFPRDLNLPKLKYLEMTGNRFMQQPLIEQFPNLVVLNFDEKFKQNMNFQAMSFFCPKLKFINGEYFEEPINEYFHTYIMEAKMALDPIIRNKWESEFADRCPNILNNQERMSLIDEMVQQLKDRNLLIDDNLSKYKDLLIFKFTEEYLKSKLNDTEDELLAGGAGSVKRSTSLYCNIEEDDDDDDEKLLERFVDV-NQNEMTILQELADELMGNNAQNIVSHVMLKTIGPNGQEQQYIVQQPQPVFHIGQSLRQNKSVVMTVIKPQAVKGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKGTPKKQKIKKQDAEKNWSNNINGPLNEISNSNDPNN--KKRGRPPKGIPGVPGNQNNYQETGPEVVERSGIVPARPKKRRTLGPFRSLRDLYKIDGIENDVIDYDPLHFIRCHAKDNAPLDQDTKVWRCVFEPNPNQPNQTTHIVATCGGECVCLIDCKVGKVMKRFKREDEEFMTLAWTTLEIEPGKRLNILAAAGKLKEIRLLFPDFLHYCDMRGHQEDISALVFHPSMPQILFSGDTKASVFIWDIGTPSANQSRLMRYQLLMRLRCPRLDVNPVLNLVFLDHYSYLVAGCEDGIFAWKITEYRSEKREREPDMELKLFVDDKIDVTLDSISYDGLAQLSRTALVFKIVHNPNLLVFDFGTTLERRKGLQKVVPIDICGTLTWQKTEDFYINVTARQNLGAVLCGDSVGNIWIYDLDPFIEECPERISRDFVCSPYKVLEWPECNVTGNERQISEQGINTSPELKSPVINTVDLSSDGLYIIAVTDNNLVCIWQLSK 1078
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000073045.1 (SMESG000073045.1)

HSP 1 Score: 950.658 bits (2456), Expect = 0.000e+0
Identity = 481/854 (56.32%), Postives = 624/854 (73.07%), Query Frame = 2 
Query:  206 LYITKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKRLQWFFTEIKDSERKDE-ELLKRFVNVYXXXXXXXXXXXRNEIVGNNIENANSQLILTTTDSGGNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKGRPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPK-----------------NHPLAQXXXXXXXXXXXKKRGRPNKQIGDIP------KPDPIQISMANNKIPPRPKMRRRNGELRSLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTDE-------NSPKL--PVINTVDMSSDGLFVVGVTDNNLVCIWKLAK 2668
            L  + +T L+EV  +K+P  +YT+I S +L++C  LRELD S NLL+EF R +NLP LK L+++ N F Q+PL+EQFPNL+VL  D   K NMN  A+++FCP LK INGE FE  + ++F  YI  A  AL+ IIRNKWE+E A+RC +IL+N  R +LIDEMV+QLKDRNLLID++LSKY+DLLIFK TE+YL+SKL + EDELL       KR    +  I++ +  D+ +LL+RFV+V  ++E+  L EL +E++GNN +N  S ++L T    G  QQ++++QP    +  QSL QNK VVMTV   + VKGRP AEFLPGELRNKDYVKG MAS IY+K VK+ LGQKG PK                 N PL +I+NSN+ N   KKRGRP K I  +P      +    ++   +  +P RPK RR  G  RSL+D+ K +G  ++ +DYDPLHFIRCHAKD+AP DQ+TKVWRC F P+   P  TTH VATCGGE VC+IDC  GKV+ R+KRE E+F+ LAWT+LEIEPG  +N+LAA GK KEIRL F D   + D++GH ED+S+L+FHPS+PQILFSGD KAS+F+WDIG PS +Q+ L+R+Q+LMRLRCPR D+NPV+NLVFLDHYSYL+AGC+D +FAWKIT+++ +K+EREPDMEL+    +K  + +DSISYDGLAQ+ RTALVF++V N N  V DFGT LERRKGLQK +PI+ CGTL W +++DFYIN+++R NLGAVL GDS+G IWIYDLDP+IEE PE+++  F C P +VL+WPECN+ G   +        SP+L  PVINTVD+SSDGL+++ VTDNNLVCIW+L+K
Sbjct:  227 LKYSSSTKLDEVRVLKIPCNNYTVIESRNLAKCVRLRELDFSENLLSEFPRDLNLPKLKYLEMTGNRFMQQPLIEQFPNLVVLNFDEKFKQNMNFQAMSFFCPKLKFINGEYFEEPINEYFHTYIMEAKMALDPIIRNKWESEFADRCPNILNNQERMSLIDEMVQQLKDRNLLIDDNLSKYKDLLIFKFTEEYLKSKLNDTEDELLAGGAGSVKRSTSLYCNIEEDDDDDDEKLLERFVDV-NQNEMTILQELADELMGNNAQNIVSHVMLKTIGPNGQEQQYIVQQPQPVFHIGQSLRQNKSVVMTVIKPQAVKGRPVAEFLPGELRNKDYVKGYMASEIYKKAVKDTLGQKGTPKKQKIKKQDAEKNWSNNINGPLNEISNSNDPNN--KKRGRPPKGIPGVPGNQNNYQETGPEVVERSGIVPARPKKRRTLGPFRSLRDLYKIDGIENDVIDYDPLHFIRCHAKDNAPLDQDTKVWRCVFEPNPNQPNQTTHIVATCGGECVCLIDCKVGKVMKRFKREDEEFMTLAWTTLEIEPGKRLNILAAAGKLKEIRLLFPDFLHYCDMRGHQEDISALVFHPSMPQILFSGDTKASVFIWDIGTPSANQSRLMRYQLLMRLRCPRLDVNPVLNLVFLDHYSYLVAGCEDGIFAWKITEYRSEKREREPDMELKLFVDDKIDVTLDSISYDGLAQLSRTALVFKIVHNPNLLVFDFGTTLERRKGLQKVVPIDICGTLTWQKTEDFYINVTARQNLGAVLCGDSVGNIWIYDLDPFIEECPERISRDFVCSPYKVLEWPECNVTGNERQISEQGINTSPELKSPVINTVDLSSDGLYIIAVTDNNLVCIWQLSK 1077
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000061887.1 (SMESG000061887.1)

HSP 1 Score: 361.688 bits (927), Expect = 7.814e-106
Identity = 174/403 (43.18%), Postives = 249/403 (61.79%), Query Frame = 2 
Query: 1502 DYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPG-TTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKE--REPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGL----QKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTD--------ENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            DYDPLHFIRCHA+D+ P D  TKVWRCAF P+   P   TT  VATCGGE VC+IDC  GKV+ R+K   E+F  +AWT++E+  G +IN+LAA GK K+IRL   ++   + ++KGH ++++ + FHP  P +LFSGDA A++ +WDIG+PS  + +   +Q+L +L CPR  LNPV+NLV +  Y  LI GC+D +F W   +F+  K +  + PD E++     +         +DGLA++  +  + + V+    F I+F  IL+  K      Q  I  +  G L W  +D+ YIN++++ NLG+V  GD+ G IW+YD+   + EN    T  F C P ++LDWPEC++    D        E   K P+IN V+MSSDG ++V VTDNNLVCIW +
Sbjct: 1475 DYDPLHFIRCHARDNNPLDCTTKVWRCAFEPNPNNPYLETTSVVATCGGECVCLIDCRTGKVMKRFKSREEEFYTVAWTTVEMAGGHYINILAAAGKMKDIRLLHPEQLVCYAEMKGHEQEIACMTFHPRYPTVLFSGDAMATVLMWDIGIPSAPEYT-THYQLLTKLMCPRAHLNPVLNLVVMPSYDALITGCEDGVFVWLFPEFRKHKPDDIQHPDFEVKVPTHQEP-------CFDGLARLSESTFLVKCVEEGEIFTINFPQILQHYKARKFDEQNRIVADVIGQLRWQITDEIYINVTAQMNLGSVTCGDNEGTIWLYDMSKEVNENNH--TRKFKCKPAKILDWPECSVESTNDNDKINQDTETVNKNPIINCVEMSSDGTYLVAVTDNNLVCIWSI 1867

HSP 2 Score: 107.071 bits (266), Expect = 3.469e-23
Identity = 55/191 (28.80%), Postives = 108/191 (56.54%), Query Frame = 2 
Query:  215 TKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKY 787
            T    L +V  + L   S+T +   D++ CYNL EL+L  N ++   R + LPNL  L++ +N F   PL+EQFP L  + +D+ +   +N +++++FCP L  IN +KFE  + D F N +  A   +E++++++WE +++      +     + +I+ +V  +++R +  +E    ++DL+  ++ E +
Sbjct:  797 TGTDDLKKVRILDLANCSFTSLMPIDINYCYNLVELNLFNNSISYLPRCLFLPNLIKLNLKKNAFVTVPLLEQFPKLYSVELDNKVARKLNKESLSFFCPELTYINEKKFEGYLSDEFNNTLVEARTYIESMVQSRWEEDLSMYFKKGVAKSEAQKVIETLVLSIRERKVFNEEKFFNFKDLVARRVAESF 987
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000061887.1 (SMESG000061887.1)

HSP 1 Score: 361.303 bits (926), Expect = 8.339e-106
Identity = 174/403 (43.18%), Postives = 249/403 (61.79%), Query Frame = 2 
Query: 1502 DYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTKVPG-TTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEPGLFINLLAAGGKSKEIRLFFSDR-ESFLDLKGHPEDVSSLIFHPSVPQILFSGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDHYSYLIAGCDDAMFAWKITDFKGDKKE--REPDMELRFTESNKAGIPIDSISYDGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGL----QKTIPIETCGTLDWLRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHCLPCRVLDWPECNIGGPTD--------ENSPKLPVINTVDMSSDGLFVVGVTDNNLVCIWKL 2662
            DYDPLHFIRCHA+D+ P D  TKVWRCAF P+   P   TT  VATCGGE VC+IDC  GKV+ R+K   E+F  +AWT++E+  G +IN+LAA GK K+IRL   ++   + ++KGH ++++ + FHP  P +LFSGDA A++ +WDIG+PS  + +   +Q+L +L CPR  LNPV+NLV +  Y  LI GC+D +F W   +F+  K +  + PD E++     +         +DGLA++  +  + + V+    F I+F  IL+  K      Q  I  +  G L W  +D+ YIN++++ NLG+V  GD+ G IW+YD+   + EN    T  F C P ++LDWPEC++    D        E   K P+IN V+MSSDG ++V VTDNNLVCIW +
Sbjct: 1461 DYDPLHFIRCHARDNNPLDCTTKVWRCAFEPNPNNPYLETTSVVATCGGECVCLIDCRTGKVMKRFKSREEEFYTVAWTTVEMAGGHYINILAAAGKMKDIRLLHPEQLVCYAEMKGHEQEIACMTFHPRYPTVLFSGDAMATVLMWDIGIPSAPEYT-THYQLLTKLMCPRAHLNPVLNLVVMPSYDALITGCEDGVFVWLFPEFRKHKPDDIQHPDFEVKVPTHQEP-------CFDGLARLSESTFLVKCVEEGEIFTINFPQILQHYKARKFDEQNRIVADVIGQLRWQITDEIYINVTAQMNLGSVTCGDNEGTIWLYDMSKEVNENNH--TRKFKCKPAKILDWPECSVESTNDNDKINQDTETVNKNPIINCVEMSSDGTYLVAVTDNNLVCIWSI 1853

HSP 2 Score: 107.071 bits (266), Expect = 3.260e-23
Identity = 55/191 (28.80%), Postives = 108/191 (56.54%), Query Frame = 2 
Query:  215 TKATSLNEVFEIKLPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQNNFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVTVPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVRQLKDRNLLIDEHLSKYRDLLIFKLTEKY 787
            T    L +V  + L   S+T +   D++ CYNL EL+L  N ++   R + LPNL  L++ +N F   PL+EQFP L  + +D+ +   +N +++++FCP L  IN +KFE  + D F N +  A   +E++++++WE +++      +     + +I+ +V  +++R +  +E    ++DL+  ++ E +
Sbjct:  797 TGTDDLKKVRILDLANCSFTSLMPIDINYCYNLVELNLFNNSISYLPRCLFLPNLIKLNLKKNAFVTVPLLEQFPKLYSVELDNKVARKLNKESLSFFCPELTYINEKKFEGYLSDEFNNTLVEARTYIESMVQSRWEEDLSMYFKKGVAKSEAQKVIETLVLSIRERKVFNEEKFFNFKDLVARRVAESF 987
The following BLAST results are available for this feature:
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
LRWD11.163e-4627.52leucine rich repeats and WD repeat domain containi... [more]
LRWD12.026e-1023.51leucine rich repeats and WD repeat domain containi... [more]
LRWD15.546e-729.07leucine rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lrwd11.157e-4227.81leucine-rich repeats and WD repeat domain containi... [more]
lrwd11.179e-4227.81leucine-rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
lrwd14.285e-4330.39leucine-rich repeats and WD repeat domain containi... [more]
lrwd14.548e-4028.85leucine-rich repeats and WD repeat domain containi... [more]
lrwd11.854e-3434.48leucine-rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Lrwd11.541e-5028.21leucine-rich repeats and WD repeat domain containi... [more]
Lrwd16.668e-629.91leucine-rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8BUI3|LRWD1_MOUSE1.078e-4928.21Leucine-rich repeat and WD repeat-containing prote... [more]
sp|B0JZ65|LRWD1_XENTR2.020e-4730.53Leucine-rich repeat and WD repeat-containing prote... [more]
sp|Q9UFC0|LRWD1_HUMAN1.628e-4527.52Leucine-rich repeat and WD repeat-containing prote... [more]
sp|Q6GM71|LRWD1_XENLA5.860e-4528.81Leucine-rich repeat and WD repeat-containing prote... [more]
sp|B0R160|LRWD1_DANRE8.900e-4227.81Leucine-rich repeat and WD repeat-containing prote... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0X3PR210.000e+041.45Putative ATP-dependent RNA helicase DDX20 OS=Schis... [more]
A0A183MXP80.000e+041.48WD_REPEATS_REGION domain-containing protein OS=Sch... [more]
G4VCV90.000e+041.23Putative dead box ATP-dependent RNA helicase OS=Sc... [more]
A0A3R7D4E00.000e+039.96Leucine-rich repeat and WD repeat-containing prote... [more]
G7Y5S20.000e+039.96ATP-dependent RNA helicase DDX20 OS=Clonorchis sin... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
lrwd17.756e-4730.81leucine rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO474661.052e-3827.54Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
lrwd13.841e-4226.46leucine rich repeats and WD repeat domain containi... [more]
lrwd13.841e-4226.46leucine rich repeats and WD repeat domain containi... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000066671.10.000e+099.53SMESG000066671.1[more]
SMESG000073045.10.000e+056.32SMESG000073045.1[more]
SMESG000073045.10.000e+056.32SMESG000073045.1[more]
SMESG000061887.17.814e-10643.18SMESG000061887.1[more]
SMESG000061887.18.339e-10643.18SMESG000061887.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30023002 ID=SMED30023002|Name=WD_REPEATS_REGION domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2748bp
TTAAAAGTATTAATTTAGTGACAATTACTTATAATCACATATCTTTGTTT
GAATATTTAAATTATTTTTTCAAAAACCTTGTAATAGATTAAAATTCATA
GAAATGTGGGGCAATAAATATGAGCCGTATTTTAATAAAGAAAAATATAT
TCCTATTGACATGACTGTAGAAGAAGTAGACAAAATTATTGACGAAGAAG
AAATTCTTTATATTACTAAAGCCACAAGTCTTAACGAAGTTTTTGAAATT
AAGTTACCTGGTAAAAGTTACACTTTGATTAATTCAACCGATTTATCACG
ATGCTACAATTTACGAGAATTGGATTTATCCGGAAATTTACTGACAGAAT
TTTCTAGAAGTATAAATTTACCGAATCTAAAAGTGTTAGATATATCGCAA
AACAATTTTTCTCAGAAACCTTTAGTTGAGCAATTCCCAAACCTAATCGT
TCTTGTTGTGGATCACAATATGAAATTAAATATGAATACAGATGCTGTAG
CATATTTTTGCCCAAATTTAAAAATAATTAATGGAGAAAAGTTTGAGGTA
ACTGTTCCAGATCATTTTATGAATTATATAACAAACGCATCAAGAGCATT
GGAAACAATAATCCGTAATAAATGGGAAAATGAAATCGCAGAAAGATGTT
ATGATATTCTTGATAATGATCATAGACGAGCTCTAATCGATGAAATGGTC
CGACAACTGAAGGACAGAAACCTGTTGATTGATGAACATCTAAGTAAATA
TCGCGATTTATTAATCTTTAAATTGACGGAAAAATATCTGGAATCCAAAT
TATATGAAGCTGAAGACGAACTATTGGTACCGGTCACGATTCCTTCTAAA
AGATTGCAATGGTTCTTTACTGAGATTAAAGATAGTGAAAGAAAAGATGA
GGAATTACTGAAGAGATTTGTCAATGTGTACGAGGAGGATGAATTGGCAG
CTTTGCTGGAATTAAGAAATGAGATAGTGGGAAATAATATAGAAAATGCC
AATAGCCAATTGATTTTGACAACAACTGATTCCGGCGGTAATCCCCAGCA
GTTTCTAATAGAACAGCCCGGTTCCAATATCAATTTCTACCAGTCTCTGA
TTCAGAACAAGGGTGTTGTGATGACTGTATTCAATGCAAAATTGGTTAAA
GGAAGACCAACTGCTGAATTTCTGCCCGGAGAACTGAGAAACAAAGATTA
TGTAAAAGGAGACATGGCATCGAACATTTACCAGAAAACTGTGAAGGAAG
TTTTAGGACAAAAAGGCCTACCAAAAAACCATCCCTTAGCACAAATAAAC
AACAGTAATAATAGCAACATCAACAGTAAAAAGCGCGGAAGACCCAATAA
ACAAATAGGAGACATACCTAAACCCGACCCCATTCAAATATCGATGGCTA
ATAATAAAATCCCACCCCGACCGAAAATGCGCCGACGAAACGGAGAGTTA
AGAAGCTTAAAAGATGTGAATAAAGCAAACGGAAGCATTAGTAACCAACT
GGATTATGATCCCCTCCATTTTATTCGCTGCCACGCTAAGGATTCAGCTC
CAAATGATCAAGAAACCAAAGTCTGGCGATGTGCTTTTGCTCCCAGTACG
AAGGTGCCCGGTACAACGACTCATTTCGTAGCAACATGCGGTGGTGAGGT
CGTCTGCGTTATTGATTGCGATTGTGGCAAAGTTGTCAACCGATACAAAC
GTGAAGGCGAAGATTTTATTGCGTTGGCTTGGACCAGCTTGGAAATCGAA
CCGGGATTATTTATAAACCTCCTAGCAGCCGGAGGAAAATCCAAAGAAAT
TCGTTTATTCTTTTCTGATAGAGAATCTTTTCTCGATTTGAAAGGCCATC
CTGAAGATGTCTCTTCGTTAATATTTCACCCATCTGTGCCGCAAATTCTC
TTCAGTGGAGACGCAAAAGCTTCGATTTTTGTGTGGGATATCGGAATGCC
TTCCAAACATCAAACGTCTTTAGTGCGCTTTCAAATGCTGATGAGACTGA
GATGTCCGAGACCGGATCTCAACCCCGTTATGAATCTCGTCTTTCTTGAC
CATTACTCCTATCTCATTGCTGGCTGTGACGATGCCATGTTTGCTTGGAA
GATCACAGATTTCAAAGGCGACAAGAAAGAAAGGGAGCCTGACATGGAGT
TAAGGTTCACAGAATCAAACAAAGCCGGAATCCCAATAGACAGCATTTCA
TATGACGGATTAGCGCAAATCGGAAGGACGGCTTTAGTTTTCCGAGTAGT
TGATAATCAGAATTTCTTTGTAATTGATTTCGGAACGATCCTTGAGCGTA
GGAAAGGCCTCCAGAAAACTATCCCAATCGAAACCTGTGGAACATTGGAT
TGGTTGCGGTCGGATGACTTCTACATCAACATCAGCTCTCGGAATAACCT
CGGTGCGGTGCTGAGCGGGGACAGCATGGGCCGGATCTGGATTTATGATC
TGGATCCGTACATTGAGGAGAACCCGGAAAAGGTAACCAATGGTTTCCAT
TGCCTGCCGTGCCGAGTGCTGGACTGGCCGGAGTGCAACATTGGTGGCCC
GACGGACGAGAACAGCCCGAAATTGCCGGTGATCAACACCGTAGACATGA
GCTCAGACGGCCTATTTGTTGTCGGGGTCACCGATAACAATCTCGTGTGC
ATTTGGAAACTCGCCAAAGATGAAATTCCCAATTGAGAAATTTTTATTTT
AGAAATACAATTTTTTCTATACAAATTTTAATAAGATTATTTTCATTG
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protein sequence of SMED30023002-orf-1

>SMED30023002-orf-1 ID=SMED30023002-orf-1|Name=SMED30023002-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=861bp
MWGNKYEPYFNKEKYIPIDMTVEEVDKIIDEEEILYITKATSLNEVFEIK
LPGKSYTLINSTDLSRCYNLRELDLSGNLLTEFSRSINLPNLKVLDISQN
NFSQKPLVEQFPNLIVLVVDHNMKLNMNTDAVAYFCPNLKIINGEKFEVT
VPDHFMNYITNASRALETIIRNKWENEIAERCYDILDNDHRRALIDEMVR
QLKDRNLLIDEHLSKYRDLLIFKLTEKYLESKLYEAEDELLVPVTIPSKR
LQWFFTEIKDSERKDEELLKRFVNVYEEDELAALLELRNEIVGNNIENAN
SQLILTTTDSGGNPQQFLIEQPGSNINFYQSLIQNKGVVMTVFNAKLVKG
RPTAEFLPGELRNKDYVKGDMASNIYQKTVKEVLGQKGLPKNHPLAQINN
SNNSNINSKKRGRPNKQIGDIPKPDPIQISMANNKIPPRPKMRRRNGELR
SLKDVNKANGSISNQLDYDPLHFIRCHAKDSAPNDQETKVWRCAFAPSTK
VPGTTTHFVATCGGEVVCVIDCDCGKVVNRYKREGEDFIALAWTSLEIEP
GLFINLLAAGGKSKEIRLFFSDRESFLDLKGHPEDVSSLIFHPSVPQILF
SGDAKASIFVWDIGMPSKHQTSLVRFQMLMRLRCPRPDLNPVMNLVFLDH
YSYLIAGCDDAMFAWKITDFKGDKKEREPDMELRFTESNKAGIPIDSISY
DGLAQIGRTALVFRVVDNQNFFVIDFGTILERRKGLQKTIPIETCGTLDW
LRSDDFYINISSRNNLGAVLSGDSMGRIWIYDLDPYIEENPEKVTNGFHC
LPCRVLDWPECNIGGPTDENSPKLPVINTVDMSSDGLFVVGVTDNNLVCI
WKLAKDEIPN*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR036322WD40_repeat_dom_sf
IPR001680WD40_repeat
IPR032675LRR_dom_sf
IPR015943WD40/YVTN_repeat-like_dom_sf
IPR025875Leu-rich_rpt_4
IPR001611Leu-rich_rpt
IPR017986WD40_repeat_dom
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004386helicase activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0045892negative regulation of transcription, DNA-templated
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001680WD40 repeatSMARTSM00320WD40_4coord: 572..612
e-value: 0.0011
score: 28.2
coord: 467..521
e-value: 490.0
score: 0.0
coord: 625..666
e-value: 380.0
score: 0.7
coord: 806..852
e-value: 21.0
score: 8.7
IPR001680WD40 repeatPROSITEPS50082WD_REPEATS_2coord: 579..613
score: 11.177
IPR025875Leucine rich repeat 4PFAMPF12799LRR_4coord: 69..103
e-value: 4.7E-7
score: 30.0
IPR015943WD40/YVTN repeat-like-containing domain superfamilyGENE3DG3DSA:2.130.10.10coord: 474..853
e-value: 2.0E-36
score: 128.0
IPR032675Leucine-rich repeat domain superfamilyGENE3DG3DSA:3.80.10.10coord: 21..151
e-value: 1.8E-14
score: 55.2
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 389..455
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 393..412
NoneNo IPR availablePANTHERPTHR24370FAMILY NOT NAMEDcoord: 37..852
NoneNo IPR availablePANTHERPTHR24370:SF10LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1coord: 37..852
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 32..143
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 69..90
score: 8.559
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 91..112
score: 6.257
IPR017986WD40-repeat-containing domainPROSITEPS50294WD_REPEATS_REGIONcoord: 579..621
score: 10.575
IPR036322WD40-repeat-containing domain superfamilySUPERFAMILYSSF50978WD40 repeat-likecoord: 486..855