Homeobox protein DTH-2

Overview


Name	Homeobox protein DTH-2
Smed ID	SMED30022975
Length (bp)	1740

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Homeobox protein DTH-2 (SMED30022975) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeobox protein DTH-2 (SMED30022975) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeobox protein DTH-2 (SMED30022975) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeobox protein DTH-2 (SMED30022975) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022975

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
zeta neoblast	SMED30022975	h1SMcG0003298	SMED30022975	smed_20140614	PMID:29906446 Zeng et al., 2018
gamma neoblast	SMED30022975	h1SMcG0003298	SMED30022975	smed_20140614	PMID:29906446 Zeng et al., 2018
parapharyngeal region	SMED30022975	h1SMcG0003298	SMED30022975	smed_20140614	PMID:29906446 Zeng et al., 2018
neoblast	SMED30022975	h1SMcG0003298	SMED30022975	smed_20140614	PMID:29906446 Zeng et al., 2018
nu neoblast	SMED30022975	h1SMcG0003298	SMED30022975	smed_20140614	PMID:29906446 Zeng et al., 2018
Smed sexual biotype	SMED30022975	h1SMcG0003298	Contig49320	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022975	h1SMcG0003298	Contig49320	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
epidermis	SMED30022975	h1SMcG0003298	dd_Smed_v4_6729_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30022975	h1SMcG0003298	dd_Smed_v4_6729_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30022975	h1SMcG0003298	dd_Smed_v4_6729_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30022975	h1SMcG0003298	dd_Smed_v4_6729_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30022975	h1SMcG0003298	dd_Smed_v4_6729_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
secretory system	SMED30022975	h1SMcG0003298	dd_Smed_v6_6729_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Human
Match: NKX2-4 (NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837])

HSP 1 Score: 127.102 bits (318), Expect = 1.446e-31
Identity = 71/137 (51.82%), Postives = 81/137 (59.12%), Query Frame = 3

Query:  699 TNSWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
               WYG      +N DPR + +SR MG +A      M    GI          A    SLG                + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  133 ATGWYG------ANPDPRYSSISRFMGPSAGVNVAGMGSLTGI----------ADAAKSLGPL-------HAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 246

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 122.479 bits (306), Expect = 8.258e-30
Identity = 73/161 (45.34%), Postives = 91/161 (56.52%), Query Frame = 3

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Human
Match: NKX2-1 (NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825])

HSP 1 Score: 122.094 bits (305), Expect = 2.000e-29
Identity = 52/58 (89.66%), Postives = 57/58 (98.28%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  191 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 248

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Match: ceh-24 (Homeobox protein ceh-24 [Source:UniProtKB/Swiss-Prot;Acc:Q9NLC2])

HSP 1 Score: 120.939 bits (302), Expect = 2.898e-30
Identity = 53/64 (82.81%), Postives = 59/64 (92.19%), Query Frame = 3

Query:  915 FNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
             +++SQRRKRR+LFSQAQ+YELERRFKQ KYL+APERE LAN I LTPTQVKIWFQNHRYKCKR
Sbjct:  144 MSSMSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRLTPTQVKIWFQNHRYKCKR 207

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 95.5153 bits (236), Expect = 3.505e-22
Identity = 41/53 (77.36%), Postives = 46/53 (86.79%), Query Frame = 3

Query:  948 ILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+
Sbjct:   63 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKK 115

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 95.9005 bits (237), Expect = 6.268e-22
Identity = 41/53 (77.36%), Postives = 46/53 (86.79%), Query Frame = 3

Query:  948 ILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+
Sbjct:  108 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKK 160

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 95.1301 bits (235), Expect = 1.493e-21
Identity = 41/53 (77.36%), Postives = 46/53 (86.79%), Query Frame = 3

Query:  948 ILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+
Sbjct:  131 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKK 183

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Match: ceh-22 (Homeobox protein ceh-22 [Source:UniProtKB/Swiss-Prot;Acc:P41936])

HSP 1 Score: 95.9005 bits (237), Expect = 2.541e-21
Identity = 41/53 (77.36%), Postives = 46/53 (86.79%), Query Frame = 3

Query:  948 ILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +LF++AQ YELERRF+ QKYLSAPERE LA  I LTPTQVKIWFQNHRYK K+
Sbjct:  194 VLFTKAQTYELERRFRSQKYLSAPEREALAMQIRLTPTQVKIWFQNHRYKTKK 246

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0339923)

HSP 1 Score: 150.214 bits (378), Expect = 1.107e-40
Identity = 83/161 (51.55%), Postives = 107/161 (66.46%), Query Frame = 3

Query:  633 SPFGSQYCSSVNDFNP---YGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            SP    YC   ++ +    Y D R + SWYG+++     +DPR A+SRLM   +++ASG MS         H G  S +   S+  +        +QF  ++QRRKRR+LF+QAQ+YELERRFKQQ+YLSAPEREHLA+LI+LTPTQVKIWFQNHRYKCKR
Sbjct:   13 SPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTA-----NDPRFAISRLM---SSSASGTMS---------HMGNMSGLAACSVSDSK------PLQFP-LAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKR 149

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0113751)

HSP 1 Score: 152.14 bits (383), Expect = 6.959e-40
Identity = 83/161 (51.55%), Postives = 107/161 (66.46%), Query Frame = 3

Query:  633 SPFGSQYCSSVNDFN---PYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            SP    YC   ++ +    Y D R + SWYG+++     +DPR A+SRLM   +++ASG MS         H G  S +   S+  +        +QF  ++QRRKRR+LF+QAQ+YELERRFKQQ+YLSAPEREHLA+LI+LTPTQVKIWFQNHRYKCKR
Sbjct:  174 SPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTA-----NDPRFAISRLM---SSSASGTMS---------HMGNMSGLAACSVSDS------KPLQFP-LAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKR 310

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Match: scro (gene:FBgn0028993 transcript:FBtr0113752)

HSP 1 Score: 116.701 bits (291), Expect = 9.894e-28
Identity = 69/147 (46.94%), Postives = 92/147 (62.59%), Query Frame = 3

Query:  633 SPFGSQYCSSVNDFNP---YGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQ 1064
            SP    YC   ++ +    Y D R + SWYG+++     +DPR A+SRLM   +++ASG MS         H G  S +   S+           +QF  ++QRRKRR+LF+QAQ+YELERRFKQQ+YLSAPEREHLA+LI+LTPTQ
Sbjct:  174 SPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTA-----NDPRFAISRLM---SSSASGTMS---------HMGNMSGLAACSVS------DSKPLQFP-LAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQ 296

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0070110)

HSP 1 Score: 115.546 bits (288), Expect = 1.147e-26
Identity = 48/59 (81.36%), Postives = 56/59 (94.92%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LF++AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  544 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKR 602

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Match: vnd (gene:FBgn0261930 transcript:FBtr0110929)

HSP 1 Score: 114.775 bits (286), Expect = 1.503e-26
Identity = 48/59 (81.36%), Postives = 56/59 (94.92%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LF++AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  398 KKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKR 456

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Match: nkx2.1 (NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1])

HSP 1 Score: 132.88 bits (333), Expect = 7.835e-34
Identity = 83/173 (47.98%), Postives = 105/173 (60.69%), Query Frame = 3

Query:  615 GVSSGSSPFGSQYCS----SVNDFNPYGDP-RGTN---SWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            GVS  S      YC+    +++D   Y D  RG+    SWYGT      N DPR + +SR MG+++    G+MS  + + ++  +GM         G  T             + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   72 GVSQLSHTAMGGYCNGNLGNMSDLPAYQDGMRGSTTATSWYGT------NPDPRFSTISRFMGSSSGMNMGSMSTLSSL-ADVGKGM---------GPLTS------------TPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 216

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Match: nkx2.4b (NK2 homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-000830-1])

HSP 1 Score: 125.946 bits (315), Expect = 1.038e-31
Identity = 69/136 (50.74%), Postives = 83/136 (61.03%), Query Frame = 3

Query:  702 NSWYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
             +WYG      SN +PR   +SR MG +A    G +            GM ++  + +L  A                RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  101 TAWYG------SNPEPRYPTISRFMGPSAGMNMGTLP-----------GMDASKSMVTLHAAP---------------RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 204

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Match: nkx2.4a (NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6336])

HSP 1 Score: 125.946 bits (315), Expect = 2.157e-31
Identity = 71/135 (52.59%), Postives = 85/135 (62.96%), Query Frame = 3

Query:  708 WYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTAT-YEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            WYG      +N DPR + +SR MG                PS       + M ++ +GT T       SI   + + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  112 WYG------ANPDPRYSTISRFMG----------------PS-------TGMNMTGMGTLTGMADTTKSIPPLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 217

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Match: nkx2.4a (NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6336])

HSP 1 Score: 122.865 bits (307), Expect = 2.148e-30
Identity = 58/86 (67.44%), Postives = 70/86 (81.40%), Query Frame = 3

Query:  852 SAMGISSLGTAT-YEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++M ++ +GT T       SI   + + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  123 TSMNMTGMGTLTGMADTTKSIPPLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 208

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Match: nkx2.2a (NK2 homeobox 2a [Source:NCBI gene;Acc:30697])

HSP 1 Score: 114.775 bits (286), Expect = 4.012e-28
Identity = 49/59 (83.05%), Postives = 56/59 (94.92%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LFS+AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  124 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR 182

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Match: trpc3 (transient receptor potential cation channel, subfamily C, member 3 [Source:Xenbase;Acc:XB-GENE-1014039])

HSP 1 Score: 127.487 bits (319), Expect = 7.330e-32
Identity = 69/134 (51.49%), Postives = 82/134 (61.19%), Query Frame = 3

Query:  708 WYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            WYG      +N+DPR + +SR MG +       M    GI         +A  ++ L  A                RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  112 WYG------ANTDPRYSTISRFMGPSTGMNMAGMGTLQGIAE-------AAKSMAPLHAAP---------------RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 217

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Match: fam221a (family with sequence similarity 221 member A [Source:Xenbase;Acc:XB-GENE-1000335])

HSP 1 Score: 125.561 bits (314), Expect = 3.958e-31
Identity = 72/152 (47.37%), Postives = 90/152 (59.21%), Query Frame = 3

Query:  663 VNDFNPYGDPRGTNS---WYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +++  PY D    +S   WYG      +N DPR + +SR MG ++    G +                   + SLG         S+     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   96 MSELPPYQDTMRNSSATGWYG------ANPDPRFSTISRFMGPSSGMNMGGLG-----------------NMGSLGDV-----GKSMTPLQATPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 219

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Match: NKX2-2 (NK2 homeobox 2 [Source:NCBI gene;Acc:100038077])

HSP 1 Score: 114.775 bits (286), Expect = 5.420e-28
Identity = 49/59 (83.05%), Postives = 56/59 (94.92%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LFS+AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  126 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR 184

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Match: NKX2-3 (NK2 homeobox 3 [Source:NCBI gene;Acc:100486189])

HSP 1 Score: 108.997 bits (271), Expect = 1.388e-25
Identity = 48/58 (82.76%), Postives = 53/58 (91.38%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            RRK R+LFSQAQ++ELERRFKQQ+YLSAPEREHLAN + LT TQVKIWFQN RYKCKR
Sbjct:  146 RRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLANSLKLTSTQVKIWFQNRRYKCKR 203

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Match: ENSXETT00000008392.1 (homeobox protein Nkx-2.1-like [Source:NCBI gene;Acc:100485697])

HSP 1 Score: 105.916 bits (263), Expect = 5.176e-25
Identity = 53/87 (60.92%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  852 SAMGISSLGTATY--EHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            S   +S+ G   Y  E  K S+   + S +RKRR+LFSQAQ+YELE+RF+ QKYL+APERE LA  I+LTP QVKIWFQNHRYK KR
Sbjct:   93 SGFNVSTAGCLGYLTEGPKHSLYLQHTS-KRKRRVLFSQAQVYELEKRFEHQKYLTAPEREQLAKHIHLTPNQVKIWFQNHRYKMKR 178

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
Match: Nkx2-4 (NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349])

HSP 1 Score: 127.872 bits (320), Expect = 4.553e-32
Identity = 68/124 (54.84%), Postives = 84/124 (67.74%), Query Frame = 3

Query:  738 NSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            N+DPR + +SR MG +A     N++           GM S  GI+       +  K+    +  + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  143 NTDPRYSSISRFMGPSAGV---NVA-----------GMGSLTGIA-------DAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 245

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
Match: Nkx2-1 (NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067])

HSP 1 Score: 122.094 bits (305), Expect = 8.559e-30
Identity = 73/161 (45.34%), Postives = 91/161 (56.52%), Query Frame = 3

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 115.161 bits (287), Expect = 3.331e-28
Identity = 49/62 (79.03%), Postives = 57/62 (91.94%), Query Frame = 3

Query:  921 NISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +  ++RKRR+LFS+AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  124 DAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR 185

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
Match: Nkx2-2 (NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347])

HSP 1 Score: 113.62 bits (283), Expect = 6.275e-28
Identity = 49/62 (79.03%), Postives = 57/62 (91.94%), Query Frame = 3

Query:  921 NISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +  ++RKRR+LFS+AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  124 DAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR 185

[Close]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Match: sp|Q00401|HMH2_GIRTI (Homeobox protein DTH-2 OS=Girardia tigrina OX=6162 GN=DTH-2 PE=2 SV=1)

HSP 1 Score: 530.406 bits (1365), Expect = 0.000e+0
Identity = 282/344 (81.98%), Postives = 312/344 (90.70%), Query Frame = 3

Query:  603 TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNI-EGKERSPGKLACNASSSPDRSTPEE-TSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN 1628
            TQHTGVSSGSSPFGSQYCSSVNDFNPY DPRG+N+WYG ++ +N+++DPRM MSRLMG+AAAAAS +MS Y+GIP+NFHQGMHSAMG++SLG ATY+HQKA++QFNN+SQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQ KEKS  HLKKNI + KERSP K  CNASSS DRSTPEE  +K KE+GL+FSNHKID LNLK EAD EPKSS YSIIPPYLT+SY+ Q+ ++ Q SPIIN+VL SNLFP+RKS P MGPL+SYSFGQSMDSISSFYSPDFSLYNCAHPYM AA SSYFMNAASRPWN
Sbjct:   23 TQHTGVSSGSSPFGSQYCSSVNDFNPYSDPRGSNTWYGMAASANASNDPRMTMSRLMGSAAAAASSSMSAYSGIPTNFHQGMHSAMGMASLGAATYDHQKAAMQFNNMSQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQQKEKSY-HLKKNIVDDKERSPNKQICNASSS-DRSTPEEPVAKAKESGLDFSNHKIDNLNLKMEADLEPKSSLYSIIPPYLTNSYAQQTQSEAQTSPIINNVLGSNLFPERKSTPTMGPLTSYSFGQSMDSISSFYSPDFSLYNCAHPYM-AASSSYFMNAASRPWN 363

[Close]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Match: sp|Q9EQM3|NKX24_MOUSE (Homeobox protein Nkx-2.4 OS=Mus musculus OX=10090 GN=Nkx2-4 PE=2 SV=2)

HSP 1 Score: 127.872 bits (320), Expect = 3.185e-31
Identity = 68/124 (54.84%), Postives = 84/124 (67.74%), Query Frame = 3

Query:  738 NSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            N+DPR + +SR MG +A     N++           GM S  GI+       +  K+    +  + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  143 NTDPRYSSISRFMGPSAGV---NVA-----------GMGSLTGIA-------DAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 245

[Close]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Match: sp|Q9H2Z4|NKX24_HUMAN (Homeobox protein Nkx-2.4 OS=Homo sapiens OX=9606 GN=NKX2-4 PE=1 SV=3)

HSP 1 Score: 127.102 bits (318), Expect = 6.946e-31
Identity = 71/137 (51.82%), Postives = 81/137 (59.12%), Query Frame = 3

Query:  699 TNSWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
               WYG      +N DPR + +SR MG +A      M    GI          A    SLG                + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  133 ATGWYG------ANPDPRYSSISRFMGPSAGVNVAGMGSLTGI----------ADAAKSLGPL-------HAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 246

[Close]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Match: sp|Q9NLC2|HM24_CAEEL (Homeobox protein ceh-24 OS=Caenorhabditis elegans OX=6239 GN=ceh-24 PE=2 SV=1)

HSP 1 Score: 120.939 bits (302), Expect = 3.686e-29
Identity = 53/64 (82.81%), Postives = 59/64 (92.19%), Query Frame = 3

Query:  915 FNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
             +++SQRRKRR+LFSQAQ+YELERRFKQ KYL+APERE LAN I LTPTQVKIWFQNHRYKCKR
Sbjct:  144 MSSMSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRLTPTQVKIWFQNHRYKCKR 207

[Close]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Match: sp|P43698|TITF1_CANLF (Thyroid transcription factor 1 OS=Canis lupus familiaris OX=9615 GN=TITF1 PE=2 SV=1)

HSP 1 Score: 122.479 bits (306), Expect = 3.928e-29
Identity = 73/161 (45.34%), Postives = 91/161 (56.52%), Query Frame = 3

Query:  651 YCSS----VNDFNPYGDPRGTNS----WYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            YC+     +++  PY D    ++    WYG      +N DPR  A+SR MG A+                   GM+ +               A +     + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:   86 YCNGNLGNMSELPPYQDTMRNSASGPGWYG------ANPDPRFPAISRFMGPAS-------------------GMNMSGMGGLGSLGDVSKNMAPLPS---APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 218

[Close]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Match: A0A267H0L1 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006911g3 PE=4 SV=1)

HSP 1 Score: 183.726 bits (465), Expect = 1.334e-48
Identity = 98/168 (58.33%), Postives = 121/168 (72.02%), Query Frame = 3

Query:  615 GVSSGSSPFGSQYCSSVNDFNPYGDPRGTN---SWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            G   G++ F SQYC+   D +PY DPR T    SWYG +S     +DPR A MSRLMG+A +A+ G  S Y+ +PS+   GM ++MG+       Y+ + A +QF  +SQRRKRR+LF+QAQ+YELERRFKQQKYLSAPERE LA +INLTPTQVKIWFQNHRYKCKR
Sbjct:   55 GPHPGAASFTSQYCAGP-DLSPYADPRHTAAAASWYGATS---PTADPRFATMSRLMGSAGSASMG--SCYSSMPSSL--GMAASMGL-----GAYDQKAAGMQFP-MSQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREQLAQMINLTPTQVKIWFQNHRYKCKR 208

[Close]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Match: A0A267E4E2 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006911g1 PE=4 SV=1)

HSP 1 Score: 183.341 bits (464), Expect = 4.126e-48
Identity = 98/168 (58.33%), Postives = 122/168 (72.62%), Query Frame = 3

Query:  615 GVSSGSSPFGSQYCSSVNDFNPYGDPRGTN---SWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            G   G++ F SQYC+   D +PY DPR T    SWYG +S     +DPR A MSRLMG+A +A+ G  S Y+ +PS+   GM ++MG+ +     Y+ + A +QF  +SQRRKRR+LF+QAQ+YELERRFKQQKYLSAPERE LA +INLTPTQVKIWFQNHRYKCKR
Sbjct:   55 GPHPGAASFTSQYCAGP-DLSPYADPRHTAAAASWYGATS---PTADPRFATMSRLMGSAGSASMG--SCYSSMPSSL--GMAASMGLGA-----YDQKAAGMQFP-MSQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREQLAQMINLTPTQVKIWFQNHRYKCKR 208

[Close]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Match: K1R0H9 (Homeobox protein Nkx-2.1 OS=Crassostrea gigas OX=29159 GN=CGI_10021129 PE=4 SV=1)

HSP 1 Score: 161.77 bits (408), Expect = 1.008e-40
Identity = 89/158 (56.33%), Postives = 111/158 (70.25%), Query Frame = 3

Query:  639 FGSQYCSSVNDFNPYGDP--RGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            + +Q+C+   +F  YGDP   G+++WYGT      N DPR+A+SRLMG  ++ A  +MS                M +S+LG    +H+   IQF  I+QRRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++INLTPTQVKIWFQNHRYKCKR
Sbjct:   76 YTTQFCNGT-EFGHYGDPTRHGSSNWYGT------NPDPRLAISRLMGGPSSCAMSSMSSGM-----------HNMNMSALG-GLDQHKAGGIQFP-ITQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMINLTPTQVKIWFQNHRYKCKR 213

[Close]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Match: A0A0K1NZ93 (NK2.1 homeobox (Fragment) OS=Priapulus caudatus OX=37621 GN=NK2.1 PE=2 SV=1)

HSP 1 Score: 157.918 bits (398), Expect = 1.152e-40
Identity = 86/169 (50.89%), Postives = 104/169 (61.54%), Query Frame = 3

Query:  609 HTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAA---ASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            H    S  S F SQYC+   + + YGDP G    + ++    +N DPR A+SRLM  ++      S  +S   GI    H+GM                     QF  ++QRRKRR+LF+QAQ+YELERRFKQQKYLSAPEREHLA+LINLTPTQVKIWFQNHRYKCKR
Sbjct:   70 HVPQLSHHSSFPSQYCNGA-ELSHYGDPTGLAVRHSSTGWYTANPDPRFAISRLMSHSSGMNMNMSSTVSALNGIDGGMHKGM---------------------QFP-LTQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 215

[Close]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Match: Q2WBW8 (Nk2.1 protein OS=Platynereis dumerilii OX=6359 GN=nk2.1 PE=2 SV=1)

HSP 1 Score: 160.614 bits (405), Expect = 2.496e-40
Identity = 85/161 (52.80%), Postives = 115/161 (71.43%), Query Frame = 3

Query:  630 SSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASG--NMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +S F SQYC+  +D + YGDP   ++ + ++S  ++N DPR+ +SRLMG ++ + SG   MS   G+    +    +  G++  G    + QK  +QF  ++QRRKRR+LF+QAQ+YELERRFKQQKYLSAPEREHLA++INLTPTQVKIWFQNHRYK KR
Sbjct:   68 TSAFPSQYCNG-SDLSHYGDPMSMSTRHSSASWYSANPDPRLTISRLMGPSSCSMSGVSGMSGMTGMSGTMNHMNMNMTGMNMSGLGGLD-QKTGMQFP-MTQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREHLASMINLTPTQVKIWFQNHRYKNKR 225

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Match: nkx2.1 (homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103043023])

HSP 1 Score: 132.88 bits (333), Expect = 5.350e-34
Identity = 72/135 (53.33%), Postives = 86/135 (63.70%), Query Frame = 3

Query:  705 SWYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            SWYGT      N DPR + +SR MG+++    G+MS    +            G+ SL +A                RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  111 SWYGT------NPDPRFSTISRFMGSSSGMNMGSMSSLGSLAD-------VGKGMGSLSSAP---------------RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 217

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Match: nkx2.4b (NK2 homeobox 4 [Source:NCBI gene;Acc:103036401])

HSP 1 Score: 125.561 bits (314), Expect = 1.497e-31
Identity = 68/136 (50.00%), Postives = 84/136 (61.76%), Query Frame = 3

Query:  702 NSWYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
             +WYG      +N +PR   +SR MG++A  A G ++           GM +   +S  GT                 RRKRR+LFSQAQ+YELERRFKQQ+YLSAPEREHLA++I+LTP QVKIWFQNHRYK KR
Sbjct:   98 TAWYG------ANPEPRYPTISRFMGSSAGMAVGALA-----------GMDTKTVVSLHGTP----------------RRKRRVLFSQAQVYELERRFKQQRYLSAPEREHLASMIHLTPNQVKIWFQNHRYKMKR 200

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Match: ENSAMXT00000002203.2 (pep primary_assembly:Astyanax_mexicanus-2.0:9:20913167:20916891:1 gene:ENSAMXG00000002158.2 transcript:ENSAMXT00000002203.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 102.064 bits (253), Expect = 4.344e-25
Identity = 47/71 (66.20%), Postives = 56/71 (78.87%), Query Frame = 3

Query:  894 HQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            H+  S       +++KRR+LFS+ Q YELERRF+QQ+YLSAPEREHLA  + LTPTQVKIWFQNHRYK KR
Sbjct:    4 HKPQSFSTEMEQKKKKRRVLFSKTQTYELERRFRQQRYLSAPEREHLARALRLTPTQVKIWFQNHRYKMKR 74

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Match: nkx2.5 (homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103025318])

HSP 1 Score: 102.449 bits (254), Expect = 1.403e-23
Identity = 45/59 (76.27%), Postives = 50/59 (84.75%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +RRK R+LFSQAQ+ ELERRF QQ+YLSA EREHLA  + LT TQVKIWFQN RYKCKR
Sbjct:  131 KRRKPRVLFSQAQVCELERRFTQQRYLSAAEREHLAGALRLTSTQVKIWFQNRRYKCKR 189

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Match: nkx2.3 (NK2 homeobox 3 [Source:NCBI gene;Acc:103034978])

HSP 1 Score: 101.293 bits (251), Expect = 3.756e-23
Identity = 43/53 (81.13%), Postives = 49/53 (92.45%), Query Frame = 3

Query:  948 ILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +LFSQAQ++ELERRFKQQ+YLSAPEREHLA+ + LT TQVKIWFQN RYKCKR
Sbjct:  154 VLFSQAQVFELERRFKQQRYLSAPEREHLASALKLTSTQVKIWFQNRRYKCKR 206

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Match: nkx2.1 (NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1])

HSP 1 Score: 122.479 bits (306), Expect = 4.166e-32
Identity = 61/117 (52.14%), Postives = 76/117 (64.96%), Query Frame = 3

Query:  756 AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            A+SR M T++    G M+ Y G+  +  + +   +                      + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:    2 AVSRFMSTSSGMNMGGMNAYGGMGGDAGKVLAPLVS---------------------TPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 97

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005776.1 (pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1 gene:ENSPMAG00000005236.1 transcript:ENSPMAT00000005776.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 104.375 bits (259), Expect = 2.418e-27
Identity = 46/59 (77.97%), Postives = 55/59 (93.22%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LFS+AQ +ELERRF+ Q+YLSAPEREHLA+L+ LTPTQVKIWFQNHRYK KR
Sbjct:    1 KKRKRRVLFSKAQTFELERRFRHQRYLSAPEREHLASLLKLTPTQVKIWFQNHRYKMKR 59

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 64.6994 bits (156), Expect = 2.666e-13
Identity = 32/57 (56.14%), Postives = 40/57 (70.18%), Query Frame = 3

Query:  936 RKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            R+ R  FS  Q+ ELER F +Q+YLS P+R  +A+ + LT TQVKIWFQN R K KR
Sbjct:    4 RRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKWKR 60

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Match: dlx5a (distal-less homeobox 5a [Source:NCBI gene;Acc:30569])

HSP 1 Score: 70.0922 bits (170), Expect = 3.434e-13
Identity = 43/104 (41.35%), Postives = 56/104 (53.85%), Query Frame = 3

Query:  936 RKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNIE--GKERSPG---KLACNASSSPDR 1232
            RK R ++S  Q+  L+RRF+Q +YL+ PER  LA  + LT TQVKIWFQN R K K+                 L KN E    + SP     +ACN+ +SP R
Sbjct:  203 RKPRTIYSSFQLAALQRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK-----------------LGKNGEMAPAQASPSSSDPMACNSPASPGR 289

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Match: HMX1 (H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:5017])

HSP 1 Score: 64.6994 bits (156), Expect = 7.199e-13
Identity = 30/58 (51.72%), Postives = 43/58 (74.14%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++K R +FS++Q+++LE  F  ++YLS+ ER  LA  ++LT TQVKIWFQN R K KR
Sbjct:    1 KKKTRTVFSRSQVFQLESTFDMKRYLSSAERAGLAASLHLTETQVKIWFQNRRNKWKR 58

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Match: EDO33946 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP5])

HSP 1 Score: 107.071 bits (266), Expect = 1.456e-27
Identity = 47/63 (74.60%), Postives = 56/63 (88.89%), Query Frame = 3

Query:  918 NNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            N   ++RKRR+LF++AQ YELERRF+QQ+YLSAPERE LA +INLTPTQVKIWFQNHRYK K+
Sbjct:    2 NEPPKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREQLARIINLTPTQVKIWFQNHRYKFKK 64

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Match: EDO45871 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRR7])

HSP 1 Score: 102.834 bits (255), Expect = 6.822e-27
Identity = 43/58 (74.14%), Postives = 55/58 (94.83%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++K+RILF+++QIYELERRF+ Q+YLSAPEREHLA +I+LTP QVKIWFQNHRYKC++
Sbjct:    1 KKKKRILFTRSQIYELERRFRVQQYLSAPEREHLARMISLTPVQVKIWFQNHRYKCRQ 58

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Match: NK-4 (NK-4 homeobox protein; Predicted protein [Source:UniProtKB/TrEMBL;Acc:Q7YZD1])

HSP 1 Score: 108.997 bits (271), Expect = 1.840e-26
Identity = 47/58 (81.03%), Postives = 53/58 (91.38%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            RRK R+LFSQAQ+YELERRFK QKYLSAPER+HLA+L+ LTP QVKIWFQN RYKCK+
Sbjct:  155 RRKPRVLFSQAQVYELERRFKGQKYLSAPERDHLASLLKLTPNQVKIWFQNKRYKCKK 212

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Match: EDO33947 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP6])

HSP 1 Score: 100.138 bits (248), Expect = 1.237e-25
Identity = 45/59 (76.27%), Postives = 54/59 (91.53%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRRILF+++QIYELERRF+ Q+YLSAPERE L  +INLTPTQVKIWFQNHRYK K+
Sbjct:    1 KKRKRRILFTKSQIYELERRFRYQRYLSAPEREQLGRMINLTPTQVKIWFQNHRYKHKK 59

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Match: NK-2 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQP7])

HSP 1 Score: 102.449 bits (254), Expect = 1.078e-24
Identity = 44/59 (74.58%), Postives = 55/59 (93.22%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            +++KRRILF+++QI+ELERRF+QQKYLSA ERE LA +I+LTPTQVKIWFQNHRYK K+
Sbjct:   90 RKKKRRILFTKSQIFELERRFRQQKYLSANEREQLARIIDLTPTQVKIWFQNHRYKFKK 148

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Match: ENSORLT00000021504.2 (NK2 homeobox 4 [Source:NCBI gene;Acc:101162726])

HSP 1 Score: 129.413 bits (324), Expect = 6.920e-33
Identity = 101/260 (38.85%), Postives = 128/260 (49.23%), Query Frame = 3

Query:  699 TNSWYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNIEGKERSPGK-LACNASSSPDRSTPEETSKVKETG----LNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVLSSNLFPDR 1460
            T +WY       SN +PR   +SR MG   A+A  NMS   G                  G A  +    S+   + + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA LI+LTP QVKIWFQNHRYK KR  KDK  +Q +  S         G+  S    L+ NA  S   S     +  ++ G    +  +  +++ L+   E ++       S  PP   H     S TD       NSV+ SNL   R
Sbjct:  107 TTAWY-------SNPEPRYPTISRYMG---ASAGMNMSGMVG------------------GLAGMDSSAKSVVTLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAGLIHLTPNQVKIWFQNHRYKLKRQAKDKAAQQPQHDSGGGAASATTGRSSSVSPVLSKNAKGSRTDSCGSNNTGNRQGGSGDAMTATPQQVNHLSSTEELED------LSPSPPMGLHDQIQMSQTDAALMDYTNSVIGSNLLYGR 332

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Match: ENSORLT00000042590.1 (NK2 homeobox 4 [Source:NCBI gene;Acc:101162726])

HSP 1 Score: 129.798 bits (325), Expect = 8.969e-33
Identity = 110/295 (37.29%), Postives = 141/295 (47.80%), Query Frame = 3

Query:  606 QHTGVSSGSSPFGSQYCSSVNDFNPYGDP----RGTNSWYGTSSLSNSNSDPRM-AMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNIEGKERSPGK-LACNASSSPDRSTPEETSKVKETG----LNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVLSSNLFPDR 1460
            Q +G  SG   F +   S+V D   Y +       T +WY       SN +PR   +SR MG   A+A  NMS   G                  G A  +    S+   + + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA LI+LTP QVKIWFQNHRYK KR  KDK  +Q +  S         G+  S    L+ NA  S   S     +  ++ G    +  +  +++ L+   E ++       S  PP   H     S TD       NSV+ SNL   R
Sbjct:   94 QFSGAVSG---FCNGGISNVGDLPTYQETVRSGGATTAWY-------SNPEPRYPTISRYMG---ASAGMNMSGMVG------------------GLAGMDSSAKSVVTLHAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAGLIHLTPNQVKIWFQNHRYKLKRQAKDKAAQQPQHDSGGGAASATTGRSSSVSPVLSKNAKGSRTDSCGSNNTGNRQGGSGDAMTATPQQVNHLSSTEELED------LSPSPPMGLHDQIQMSQTDAALMDYTNSVIGSNLLYGR 351

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Match: nkx2.1 (NK2 homeobox 1 [Source:NCBI gene;Acc:100049404])

HSP 1 Score: 128.642 bits (322), Expect = 1.888e-32
Identity = 69/134 (51.49%), Postives = 85/134 (63.43%), Query Frame = 3

Query:  708 WYGTSSLSNSNSDPRMA-MSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            WYG      +N DPR + +SR MG+++    G+M     +            G+SSL +               + RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  111 WYG------ANPDPRFSTISRFMGSSSGMNMGSMGSLGSLAD-------VGKGMSSLSS---------------TPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 216

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Match: nkx2.4a (homeobox protein Nkx-2.4-like [Source:NCBI gene;Acc:101163285])

HSP 1 Score: 122.094 bits (305), Expect = 4.062e-30
Identity = 52/58 (89.66%), Postives = 57/58 (98.28%), Query Frame = 3

Query:  933 RRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            RRKRR+LFSQAQ+YELERRFKQQKYLSAPEREHLA++I+LTPTQVKIWFQNHRYK KR
Sbjct:  151 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKR 208

[Close]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Match: nkx2.2a (homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:101157822])

HSP 1 Score: 114.39 bits (285), Expect = 4.843e-28
Identity = 49/59 (83.05%), Postives = 56/59 (94.92%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++RKRR+LFS+AQ YELERRF+QQ+YLSAPEREHLA+LI LTPTQVKIWFQNHRYK KR
Sbjct:  128 KKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR 186

[Close]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 341/342 (99.71%), Postives = 342/342 (100.00%), Query Frame = 3

Query:  603 TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN 1628
            TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEKSSCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLT+SYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN
Sbjct:   14 TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEKSSCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTNSYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN 355

[Close]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Match: SMESG000037282.1 (SMESG000037282.1)

HSP 1 Score: 674.47 bits (1739), Expect = 0.000e+0
Identity = 341/342 (99.71%), Postives = 342/342 (100.00%), Query Frame = 3

Query:  603 TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRXXXXXXXXXXXXXXXCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN 1628
            TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEKSSCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLT+SYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN
Sbjct:   23 TQHTGVSSGSSPFGSQYCSSVNDFNPYGDPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNFHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQLKEKSSCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSNHKIDGLNLKTEADNEPKSSFYSIIPPYLTNSYSHQSLTDTQASPIINSVLSSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAAGSSYFMNAASRPWN 364

[Close]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Match: SMESG000081885.1 (SMESG000081885.1)

HSP 1 Score: 119.398 bits (298), Expect = 4.854e-29
Identity = 74/131 (56.49%), Postives = 90/131 (68.70%), Query Frame = 3

Query:  738 NSDPRMAMSRLMGTAAAAASGN-------MSVYAGIPSN-FHQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            N+D R A+S+L+G A+  +SG        MS +   PS+ + +  +   G S +    Y+           SQRR+RRILFSQAQ+YELERRFKQQKYLSAPEREHLA+LINLTPTQVKIWFQNHRYKCKR
Sbjct:   70 NTDTRSAVSKLIG-ASDTSSGTAYNPCNLMSPF--FPSSRYDRSSNLFSGNSPINGMLYQSH---------SQRRRRRILFSQAQVYELERRFKQQKYLSAPEREHLASLINLTPTQVKIWFQNHRYKCKR 188

[Close]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Match: SMESG000062916.1 (SMESG000062916.1)

HSP 1 Score: 110.923 bits (276), Expect = 3.944e-27
Identity = 49/59 (83.05%), Postives = 53/59 (89.83%), Query Frame = 3

Query:  930 QRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            QRRKRRILFSQ+Q+YELER+FK QKYLSA ER+ LA  INLTP QVKIWFQNHRYKCKR
Sbjct:  129 QRRKRRILFSQSQVYELERKFKHQKYLSASERDQLAQTINLTPNQVKIWFQNHRYKCKR 187

[Close]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Match: SMESG000079512.1 (SMESG000079512.1)

HSP 1 Score: 111.309 bits (277), Expect = 9.733e-26
Identity = 47/62 (75.81%), Postives = 56/62 (90.32%), Query Frame = 3

Query:  921 NISQRRKRRILFSQAQIYELERRFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKR 1106
            ++ ++RKRR+LFS+ QI ELER F+Q+KYLSAPEREHLANLI L+PTQVKIWFQNHRYK KR
Sbjct:  362 DVGKKRKRRVLFSKKQILELERHFRQKKYLSAPEREHLANLIGLSPTQVKIWFQNHRYKMKR 423

The following BLAST results are available for this feature:

BLAST of Homeobox protein DTH-2 vs. Ensembl Human
BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
BLAST of Homeobox protein DTH-2 vs. TrEMBL
BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
BLAST of Homeobox protein DTH-2 vs. Ensembl Yeast
BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
BLAST of Homeobox protein DTH-2 vs. Planmine SMEST

BLAST of Homeobox protein DTH-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NKX2-4	1.446e-31	51.82	NK2 homeobox 4 [Source:HGNC Symbol;Acc:HGNC:7837]	[more]
NKX2-1	8.258e-30	45.34	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]
NKX2-1	8.258e-30	45.34	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]
NKX2-1	8.258e-30	45.34	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]
NKX2-1	2.000e-29	89.66	NK2 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11825]	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ceh-24	2.898e-30	82.81	Homeobox protein ceh-24 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	3.505e-22	77.36	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	6.268e-22	77.36	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	1.493e-21	77.36	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]
ceh-22	2.541e-21	77.36	Homeobox protein ceh-22 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
scro	1.107e-40	51.55	gene:FBgn0028993 transcript:FBtr0339923	[more]
scro	6.959e-40	51.55	gene:FBgn0028993 transcript:FBtr0113751	[more]
scro	9.894e-28	46.94	gene:FBgn0028993 transcript:FBtr0113752	[more]
vnd	1.147e-26	81.36	gene:FBgn0261930 transcript:FBtr0070110	[more]
vnd	1.503e-26	81.36	gene:FBgn0261930 transcript:FBtr0110929	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx2.1	7.835e-34	47.98	NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1]	[more]
nkx2.4b	1.038e-31	50.74	NK2 homeobox 4b [Source:ZFIN;Acc:ZDB-GENE-000830-1...	[more]
nkx2.4a	2.157e-31	52.59	NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6...	[more]
nkx2.4a	2.148e-30	67.44	NK2 homeobox 4a [Source:ZFIN;Acc:ZDB-GENE-030131-6...	[more]
nkx2.2a	4.012e-28	83.05	NK2 homeobox 2a [Source:NCBI gene;Acc:30697]	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
trpc3	7.330e-32	51.49	transient receptor potential cation channel, subfa...	[more]
fam221a	3.958e-31	47.37	family with sequence similarity 221 member A [Sour...	[more]
NKX2-2	5.420e-28	83.05	NK2 homeobox 2 [Source:NCBI gene;Acc:100038077]	[more]
NKX2-3	1.388e-25	82.76	NK2 homeobox 3 [Source:NCBI gene;Acc:100486189]	[more]
ENSXETT00000008392.1	5.176e-25	60.92	homeobox protein Nkx-2.1-like [Source:NCBI gene;Ac...	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nkx2-4	4.553e-32	54.84	NK2 homeobox 4 [Source:MGI Symbol;Acc:MGI:97349]	[more]
Nkx2-1	8.559e-30	45.34	NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067]	[more]
Nkx2-1	8.559e-30	45.34	NK2 homeobox 1 [Source:MGI Symbol;Acc:MGI:108067]	[more]
Nkx2-2	3.331e-28	79.03	NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347]	[more]
Nkx2-2	6.275e-28	79.03	NK2 homeobox 2 [Source:MGI Symbol;Acc:MGI:97347]	[more]

BLAST of Homeobox protein DTH-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q00401\|HMH2_GIRTI	0.000e+0	81.98	Homeobox protein DTH-2 OS=Girardia tigrina OX=6162...	[more]
sp\|Q9EQM3\|NKX24_MOUSE	3.185e-31	54.84	Homeobox protein Nkx-2.4 OS=Mus musculus OX=10090 ...	[more]
sp\|Q9H2Z4\|NKX24_HUMAN	6.946e-31	51.82	Homeobox protein Nkx-2.4 OS=Homo sapiens OX=9606 G...	[more]
sp\|Q9NLC2\|HM24_CAEEL	3.686e-29	82.81	Homeobox protein ceh-24 OS=Caenorhabditis elegans ...	[more]
sp\|P43698\|TITF1_CANLF	3.928e-29	45.34	Thyroid transcription factor 1 OS=Canis lupus fami...	[more]

BLAST of Homeobox protein DTH-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267H0L1	1.334e-48	58.33	Homeobox domain-containing protein OS=Macrostomum ...	[more]
A0A267E4E2	4.126e-48	58.33	Homeobox domain-containing protein OS=Macrostomum ...	[more]
K1R0H9	1.008e-40	56.33	Homeobox protein Nkx-2.1 OS=Crassostrea gigas OX=2...	[more]
A0A0K1NZ93	1.152e-40	50.89	NK2.1 homeobox (Fragment) OS=Priapulus caudatus OX...	[more]
Q2WBW8	2.496e-40	52.80	Nk2.1 protein OS=Platynereis dumerilii OX=6359 GN=...	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx2.1	5.350e-34	53.33	homeobox protein Nkx-2.1 [Source:NCBI gene;Acc:103...	[more]
nkx2.4b	1.497e-31	50.00	NK2 homeobox 4 [Source:NCBI gene;Acc:103036401]	[more]
ENSAMXT00000002203.2	4.344e-25	66.20	pep primary_assembly:Astyanax_mexicanus-2.0:9:2091...	[more]
nkx2.5	1.403e-23	76.27	homeobox protein Nkx-2.5 [Source:NCBI gene;Acc:103...	[more]
nkx2.3	3.756e-23	81.13	NK2 homeobox 3 [Source:NCBI gene;Acc:103034978]	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nkx2.1	4.166e-32	52.14	NK2 homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-010404-1]	[more]
ENSPMAT00000005776.1	2.418e-27	77.97	pep scaffold:Pmarinus_7.0:GL477528:542110:542457:1...	[more]
ENSPMAT00000001141.1	2.666e-13	56.14	pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 ...	[more]
dlx5a	3.434e-13	41.35	distal-less homeobox 5a [Source:NCBI gene;Acc:3056...	[more]
HMX1	7.199e-13	51.72	H6 family homeobox 1 [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Homeobox protein DTH-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO33946	1.456e-27	74.60	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45871	6.822e-27	74.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
NK-4	1.840e-26	81.03	NK-4 homeobox protein; Predicted protein [Source:...	[more]
EDO33947	1.237e-25	76.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
NK-2	1.078e-24	74.58	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Homeobox protein DTH-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000021504.2	6.920e-33	38.85	NK2 homeobox 4 [Source:NCBI gene;Acc:101162726]	[more]
ENSORLT00000042590.1	8.969e-33	37.29	NK2 homeobox 4 [Source:NCBI gene;Acc:101162726]	[more]
nkx2.1	1.888e-32	51.49	NK2 homeobox 1 [Source:NCBI gene;Acc:100049404]	[more]
nkx2.4a	4.062e-30	89.66	homeobox protein Nkx-2.4-like [Source:NCBI gene;Ac...	[more]
nkx2.2a	4.843e-28	83.05	homeobox protein Nkx-2.2a [Source:NCBI gene;Acc:10...	[more]

BLAST of Homeobox protein DTH-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000037282.1	0.000e+0	99.71	SMESG000037282.1	[more]
SMESG000037282.1	0.000e+0	99.71	SMESG000037282.1	[more]
SMESG000081885.1	4.854e-29	56.49	SMESG000081885.1	[more]
SMESG000062916.1	3.944e-27	83.05	SMESG000062916.1	[more]
SMESG000079512.1	9.733e-26	75.81	SMESG000079512.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022975 ID=SMED30022975|Name=Homeobox protein DTH-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1740bp
CTAAATTTGATTCATTAGTAATTTATTTTGAAAAATTATTCCATAGGCAG
AGCAGTCGATGTGCATGAAATAAGAAATTACCTGTGACCGAGTATGACTG
TATGTGGACAGAAATTGAGAAGCATGCAAACTGATGAAATGAAAAACGTG
GTTACGAATGTTCACGGTGTACGGTAATTGCTTTATTGTATGTTGGTAAG
GTAGCGATAAGTATGCATTTAAGTAAGTAGAACACACTGGCTTGAGTTTA
GTTGTGAAATATACAAATAATCAGTGAAGCACGATCAAATCAGCACCAAT
AAATGCAACCAGATAACACTTGGTACTTAATATCTAAACTCAGGACTAGA
TAGTTATTAATTCAGCTTTGCCTTTAAACTTACTACTCAAGTATCTGTTA
TAGGTATTTGTAATCATCTATTTGAATAACACTTAACACTTTCTGTGAGA
ACCTTTATTATCTAAACTGGTACTAGGAGAAGTACTACTTCAAGACTACT
CAACTAAGTGAGACACCCATCATTCATAAAGCTGCTATGAGTGGTATACC
TGGACTCTCTGGAATGTCCTCAATGTCACCATATTCTGCATATGCTGCAT
TAACTCAGCATACTGGTGTCAGTTCTGGCTCCTCACCATTTGGATCTCAA
TATTGTTCAAGTGTAAATGATTTCAATCCCTATGGTGATCCAAGAGGAAC
CAATTCTTGGTATGGAACATCATCACTATCTAATTCAAACAGTGATCCGC
GTATGGCGATGTCTCGATTGATGGGAACTGCAGCGGCAGCTGCAAGTGGA
AACATGTCAGTTTATGCGGGAATTCCTTCTAATTTCCATCAAGGTATGCA
TTCTGCAATGGGAATATCTTCATTGGGAACGGCCACTTATGAACATCAAA
AAGCTTCAATTCAATTTAACAATATATCTCAACGTCGAAAACGACGAATT
TTATTTAGTCAAGCTCAGATTTATGAACTTGAGCGTCGATTTAAACAACA
AAAGTATTTGTCTGCTCCAGAAAGAGAACATTTAGCTAATTTAATAAATT
TAACTCCCACTCAGGTAAAGATTTGGTTTCAAAATCATCGTTATAAATGT
AAAAGATCTCAAAAGGATAAAGAAAAAGAGCAACTAAAAGAAAAATCATC
ATGTCATTTAAAAAAAAATATTGAAGGTAAAGAAAGATCACCCGGTAAAC
TTGCATGCAATGCATCTAGTTCCCCAGATAGAAGCACTCCCGAGGAAACA
TCAAAAGTCAAAGAAACTGGACTCAATTTTAGTAATCACAAAATTGATGG
CCTTAATTTAAAAACTGAAGCCGACAATGAACCGAAATCGTCCTTTTACT
CTATAATACCTCCCTATTTAACCCATTCCTATTCACATCAAAGCCTAACG
GATACTCAAGCTTCTCCTATAATTAATAGTGTGCTTAGTTCAAATCTTTT
CCCGGACAGAAAATCTCCCCCGGCAATGGGGCCTCTGAGTAGTTATTCAT
TCGGACAATCTATGGATTCGATTTCCAGTTTTTATTCACCGGACTTTTCC
CTGTATAATTGCGCCCATCCGTACATGTCAGCTGCTGGTTCGTCCTATTT
CATGAATGCGGCTTCTAGGCCGTGGAATTAAAATTTTAAGTCAACTATGA
GAAATATTTAAATTTCATTTATTGTTAATTTTTGTGCAAATAGATTTGAT
TTCTGAATTTTCTTATTAGTTTTTTTAAAATCAAAAAAAG

protein sequence of SMED30022975-orf-1

>SMED30022975-orf-1 ID=SMED30022975-orf-1|Name=SMED30022975-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=365bp
MSGIPGLSGMSSMSPYSAYAALTQHTGVSSGSSPFGSQYCSSVNDFNPYG
DPRGTNSWYGTSSLSNSNSDPRMAMSRLMGTAAAAASGNMSVYAGIPSNF
HQGMHSAMGISSLGTATYEHQKASIQFNNISQRRKRRILFSQAQIYELER
RFKQQKYLSAPEREHLANLINLTPTQVKIWFQNHRYKCKRSQKDKEKEQL
KEKSSCHLKKNIEGKERSPGKLACNASSSPDRSTPEETSKVKETGLNFSN
HKIDGLNLKTEADNEPKSSFYSIIPPYLTHSYSHQSLTDTQASPIINSVL
SSNLFPDRKSPPAMGPLSSYSFGQSMDSISSFYSPDFSLYNCAHPYMSAA
GSSYFMNAASRPWN*

Aliases

The feature 'Homeobox protein DTH-2' has the following synonyms


Synonym
nkx2.4*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000014	zeta neoblast
PLANA:0000039	gamma neoblast
PLANA:0000420	parapharyngeal region
PLANA:0000429	neoblast
PLANA:0000484	secretory system
PLANA:0002032	epidermal cell
PLANA:0003117	parapharyngeal cell
PLANA:0007552	nu neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR020479	Homeobox_metazoa
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organism development

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 183..203
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 128..209 e-value: 2.4E-24 score: 86.7
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 217..244
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 222..244
None	No IPR available	PANTHER	PTHR24340:SF41	SCARECROW, ISOFORM A	coord: 32..285
None	No IPR available	PANTHER	PTHR24340	FAMILY NOT NAMED	coord: 32..285
IPR020479	Homeobox domain, metazoa	PRINTS	PR00024	HOMEOBOX	coord: 170..180 score: 57.42 coord: 155..166 score: 41.38 coord: 180..189 score: 69.65
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 133..195 e-value: 5.0E-25 score: 99.1
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 134..190 e-value: 1.2E-19 score: 69.9
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 131..191 score: 19.791
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 134..192 e-value: 1.53877E-24 score: 92.6916
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 166..189
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 119..193

Main menu

Homeobox protein DTH-2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Owlery

blazegraph-runner