Rho GTPase-activating protein 12

Overview
NameRho GTPase-activating protein 12
Smed IDSMED30022973
Length (bp)4024
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Rho GTPase-activating protein 12 (SMED30022973) t-SNE clustered cells

Violin plots show distribution of expression levels for Rho GTPase-activating protein 12 (SMED30022973) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Rho GTPase-activating protein 12 (SMED30022973) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Rho GTPase-activating protein 12 (SMED30022973) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30022973

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 16

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30022973h1SMcG0014922 PL06004A2H07smed_ncbi_20240424PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30022973h1SMcG0014922 Contig4200newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30022973h1SMcG0014922 Contig4200uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30022973h1SMcG0014922 PL08001B1B06smed_ncbi_20240424PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30022973h1SMcG0017943 Contig4200newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30022973h1SMcG0017943 Contig4200uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Smed sexual biotypeSMED30022973h1SMcG0014922 Contig30832uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30022973h1SMcG0014922 Contig30832newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
pharynxSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30022973h1SMcG0014922 dd_Smed_v4_4253_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Match: CHN1 (chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943])

HSP 1 Score: 60.077 bits (144), Expect = 3.937e-9
Identity = 56/210 (26.67%), Postives = 91/210 (43.33%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +     +F E  +  D    L+     L+L    P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:   57 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY----PKFIESAKIMDPDEQLETLHEALKL---LPPAHCE----------------------TLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 234
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Match: CHN1 (chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943])

HSP 1 Score: 60.4622 bits (145), Expect = 6.494e-9
Identity = 53/210 (25.24%), Postives = 92/210 (43.81%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +       ++ ++P++    L  A       ++ P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:  108 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIES-AKIMDPDEQLETLHEAL------KLLPPAHCE----------------------TLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 285
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Match: CHN1 (chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943])

HSP 1 Score: 58.9214 bits (141), Expect = 1.710e-8
Identity = 53/210 (25.24%), Postives = 92/210 (43.81%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +       ++ ++P++    L  A       ++ P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:   98 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIES-AKIMDPDEQLETLHEAL------KLLPPAHCE----------------------TLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 275
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Match: CHN1 (chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943])

HSP 1 Score: 58.5362 bits (140), Expect = 2.356e-8
Identity = 53/210 (25.24%), Postives = 92/210 (43.81%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +       ++ ++P++    L  A       ++ P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:  100 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIES-AKIMDPDEQLETLHEAL------KLLPPAHCE----------------------TLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 277
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Match: ARHGAP21 (Rho GTPase activating protein 21 [Source:HGNC Symbol;Acc:HGNC:23725])

HSP 1 Score: 58.5362 bits (140), Expect = 9.152e-8
Identity = 44/165 (26.67%), Postives = 73/165 (44.24%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V +C  L+EE GL   GIYR  GN     ++++ +     D     D+W +++ ++SL KS  RK    L   D           ++ + K D   +L+ +  +I+ L  +             ++T KF+  HL  +    E  KM   NLA+ F   L+
Sbjct:  948 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADF------IEANRKEDPLDRLKTLKRLIHDLPEHH------------YETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLV 1094
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Match: pac-1 (GTPase-activating protein pac-1 [Source:UniProtKB/Swiss-Prot;Acc:P34288])

HSP 1 Score: 63.929 bits (154), Expect = 1.042e-9
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct: 1055 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 1232
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Match: pac-1 (GTPase-activating protein pac-1 [Source:UniProtKB/Swiss-Prot;Acc:P34288])

HSP 1 Score: 63.5438 bits (153), Expect = 1.171e-9
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct:  941 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 1118
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Match: pac-1 (GTPase-activating protein pac-1 [Source:UniProtKB/Swiss-Prot;Acc:P34288])

HSP 1 Score: 63.5438 bits (153), Expect = 1.210e-9
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct:  580 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 757
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Match: pac-1 (GTPase-activating protein pac-1 [Source:UniProtKB/Swiss-Prot;Acc:P34288])

HSP 1 Score: 63.1586 bits (152), Expect = 1.329e-9
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct:  475 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 652
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Match: pac-1 (GTPase-activating protein pac-1 [Source:UniProtKB/Swiss-Prot;Acc:P34288])

HSP 1 Score: 63.1586 bits (152), Expect = 1.406e-9
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct:  942 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 1119
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Match: RhoGAPp190 (gene:FBgn0026375 transcript:FBtr0333659)

HSP 1 Score: 71.2478 bits (173), Expect = 6.407e-12
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1344 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1555
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Match: RhoGAPp190 (gene:FBgn0026375 transcript:FBtr0074481)

HSP 1 Score: 71.2478 bits (173), Expect = 6.794e-12
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1341 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1552
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Match: RhoGAPp190 (gene:FBgn0026375 transcript:FBtr0074482)

HSP 1 Score: 71.2478 bits (173), Expect = 6.794e-12
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1341 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1552
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Match: RhoGAPp190 (gene:FBgn0026375 transcript:FBtr0074483)

HSP 1 Score: 71.2478 bits (173), Expect = 6.794e-12
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1341 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1552
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Match: RhoGAPp190 (gene:FBgn0026375 transcript:FBtr0333661)

HSP 1 Score: 71.2478 bits (173), Expect = 6.970e-12
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1401 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1612
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Match: chn2 (chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5])

HSP 1 Score: 67.781 bits (164), Expect = 5.152e-11
Identity = 60/208 (28.85%), Postives = 99/208 (47.60%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL+ +G+YRVSG       ++ + +  D D    + S  I+  ++  A  +K  L+    IP  T+  + S+F +  +  D  + L+A   H  L Q+ P+ Y                        TLRY++ HLK V+++E  N M + +L + F P LM     + +  +N    Q  IVQLLI+H D +F
Sbjct:  273 PMVLDMCIREIEHRGLKSEGLYRVSGFT---EHIEDVRLSFDRDGEKADISANIYPDINIIAGALKLYLRDLP-IPVITY-DVYSRFIQAAKITDPDSRLEAV--HDGLLQLPPAHY-----------------------ETLRYLMTHLKRVTMYEKDNYMNSENLGIVFGPTLMRPPDLNTLTTLNDMRYQKLIVQLLIEHEDILF 450
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Match: chn2 (chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5])

HSP 1 Score: 67.781 bits (164), Expect = 5.675e-11
Identity = 60/208 (28.85%), Postives = 99/208 (47.60%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL+ +G+YRVSG       ++ + +  D D    + S  I+  ++  A  +K  L+    IP  T+  + S+F +  +  D  + L+A   H  L Q+ P+ Y                        TLRY++ HLK V+++E  N M + +L + F P LM     + +  +N    Q  IVQLLI+H D +F
Sbjct:  289 PMVLDMCIREIEHRGLKSEGLYRVSGFT---EHIEDVRLSFDRDGEKADISANIYPDINIIAGALKLYLRDLP-IPVITY-DVYSRFIQAAKITDPDSRLEAV--HDGLLQLPPAHY-----------------------ETLRYLMTHLKRVTMYEKDNYMNSENLGIVFGPTLMRPPDLNTLTTLNDMRYQKLIVQLLIEHEDILF 466
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Match: arhgap12b (Rho GTPase activating protein 12b [Source:ZFIN;Acc:ZDB-GENE-040426-1727])

HSP 1 Score: 62.7734 bits (151), Expect = 2.578e-9
Identity = 59/208 (28.37%), Postives = 97/208 (46.63%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL VDG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +  F++ +E       +K + Y  R++ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  687 VPNFVKMCIEHVENTGLNVDGLYRVSG-NLAVIQKLRFAVNHDEKVNLDDSK---WEDIHVTTG---ALKMLFRELPEPLFTYAS--FNDFVE------AIKNSDYKQRVQSIK---------------DLIKQLP-KPNQETMKVLFKHLKRVIDHGEVNRMTTQSVAIVFGPTLLRPEIETGNMAVHMVYQNQIVELILLEYENIF 863
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Match: arhgap12b (Rho GTPase activating protein 12b [Source:ZFIN;Acc:ZDB-GENE-040426-1727])

HSP 1 Score: 62.7734 bits (151), Expect = 2.918e-9
Identity = 59/208 (28.37%), Postives = 97/208 (46.63%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL VDG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +  F++ +E       +K + Y  R++ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  663 VPNFVKMCIEHVENTGLNVDGLYRVSG-NLAVIQKLRFAVNHDEKVNLDDSK---WEDIHVTTG---ALKMLFRELPEPLFTYAS--FNDFVE------AIKNSDYKQRVQSIK---------------DLIKQLP-KPNQETMKVLFKHLKRVIDHGEVNRMTTQSVAIVFGPTLLRPEIETGNMAVHMVYQNQIVELILLEYENIF 839
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Match: arhgap12b (Rho GTPase activating protein 12b [Source:ZFIN;Acc:ZDB-GENE-040426-1727])

HSP 1 Score: 62.7734 bits (151), Expect = 2.918e-9
Identity = 59/208 (28.37%), Postives = 97/208 (46.63%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL VDG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +  F++ +E       +K + Y  R++ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  663 VPNFVKMCIEHVENTGLNVDGLYRVSG-NLAVIQKLRFAVNHDEKVNLDDSK---WEDIHVTTG---ALKMLFRELPEPLFTYAS--FNDFVE------AIKNSDYKQRVQSIK---------------DLIKQLP-KPNQETMKVLFKHLKRVIDHGEVNRMTTQSVAIVFGPTLLRPEIETGNMAVHMVYQNQIVELILLEYENIF 839
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Match: ARHGAP23 (Rho GTPase activating protein 23 [Source:NCBI gene;Acc:100496640])

HSP 1 Score: 73.9442 bits (180), Expect = 2.155e-12
Identity = 84/314 (26.75%), Postives = 141/314 (44.90%), Query Frame = 2 
Query: 2474 SVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIK--IWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
             VKQ  S K  R  + G   DLL ++ ++ P      + K D   +  +P S+    G   + L K  KK   + FG    V++     + ++K VPL++  C   +E  GL   GIYRV G N  +S L + +     +K   ES+I+   W  L+  + L+K     F  +P+   +    ++S+ +E   +++  +      +L +  PS Y                        TLR+++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  + + AE
Sbjct:  855 GVKQETSPKGSR--SLGIRPDLLWTSGVSAP-----RSPKQDGAAKEEAPPSK----GAWGINLMKKNKKCPPRAFG----VRLEDCQPAAENKGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHL-----NKGLSESNIQDQRWQDLNVVSSLLKSF---FRKLPEP--LFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYE----------------------TLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFSEEQEKAE 1121

HSP 2 Score: 56.6102 bits (135), Expect = 3.458e-7
Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 2 
Query: 1613 EGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDE-WFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +GVPL V LC S +E+ GL  +GIYR  GN     +L++  +N+   + +  D+ W +++ V+SL KS  RK    L   D           ++ +   D  ++++ +  +I  L   +            ++T +F+++HL  +    E  KM   NLAL F   L+
Sbjct:  933 KGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQE-HLNKGLSESNIQDQRWQDLNVVSSLLKSFFRKLPEPLFTDDKYSDF------IEANRMEDSRERMKMLRKLIKELPSYY------------YETLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLV 1081
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Match: ARHGAP23 (Rho GTPase activating protein 23 [Source:NCBI gene;Acc:100496640])

HSP 1 Score: 73.559 bits (179), Expect = 2.408e-12
Identity = 84/314 (26.75%), Postives = 141/314 (44.90%), Query Frame = 2 
Query: 2474 SVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIK--IWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
             VKQ  S K  R  + G   DLL ++ ++ P      + K D   +  +P S+    G   + L K  KK   + FG    V++     + ++K VPL++  C   +E  GL   GIYRV G N  +S L + +     +K   ES+I+   W  L+  + L+K     F  +P+   +    ++S+ +E   +++  +      +L +  PS Y                        TLR+++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  + + AE
Sbjct:  862 GVKQETSPKGSR--SLGIRPDLLWTSGVSAP-----RSPKQDGAAKEEAPPSK----GAWGINLMKKNKKCPPRAFG----VRLEDCQPAAENKGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHL-----NKGLSESNIQDQRWQDLNVVSSLLKSF---FRKLPEP--LFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYE----------------------TLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFSEEQEKAE 1128

HSP 2 Score: 56.6102 bits (135), Expect = 4.028e-7
Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 2 
Query: 1613 EGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDE-WFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +GVPL V LC S +E+ GL  +GIYR  GN     +L++  +N+   + +  D+ W +++ V+SL KS  RK    L   D           ++ +   D  ++++ +  +I  L   +            ++T +F+++HL  +    E  KM   NLAL F   L+
Sbjct:  940 KGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQE-HLNKGLSESNIQDQRWQDLNVVSSLLKSFFRKLPEPLFTDDKYSDF------IEANRMEDSRERMKMLRKLIKELPSYY------------YETLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLV 1088
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Match: ARHGAP23 (Rho GTPase activating protein 23 [Source:NCBI gene;Acc:100496640])

HSP 1 Score: 73.559 bits (179), Expect = 2.485e-12
Identity = 84/314 (26.75%), Postives = 141/314 (44.90%), Query Frame = 2 
Query: 2474 SVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIK--IWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
             VKQ  S K  R  + G   DLL ++ ++ P      + K D   +  +P S+    G   + L K  KK   + FG    V++     + ++K VPL++  C   +E  GL   GIYRV G N  +S L + +     +K   ES+I+   W  L+  + L+K     F  +P+   +    ++S+ +E   +++  +      +L +  PS Y                        TLR+++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  + + AE
Sbjct:  803 GVKQETSPKGSR--SLGIRPDLLWTSGVSAP-----RSPKQDGAAKEEAPPSK----GAWGINLMKKNKKCPPRAFG----VRLEDCQPAAENKGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHL-----NKGLSESNIQDQRWQDLNVVSSLLKSF---FRKLPEP--LFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYE----------------------TLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFSEEQEKAE 1069

HSP 2 Score: 56.6102 bits (135), Expect = 3.999e-7
Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 2 
Query: 1613 EGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDE-WFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +GVPL V LC S +E+ GL  +GIYR  GN     +L++  +N+   + +  D+ W +++ V+SL KS  RK    L   D           ++ +   D  ++++ +  +I  L   +            ++T +F+++HL  +    E  KM   NLAL F   L+
Sbjct:  881 KGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQE-HLNKGLSESNIQDQRWQDLNVVSSLLKSFFRKLPEPLFTDDKYSDF------IEANRMEDSRERMKMLRKLIKELPSYY------------YETLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLV 1029
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Match: ARHGAP23 (Rho GTPase activating protein 23 [Source:NCBI gene;Acc:100496640])

HSP 1 Score: 73.1738 bits (178), Expect = 2.967e-12
Identity = 84/314 (26.75%), Postives = 141/314 (44.90%), Query Frame = 2 
Query: 2474 SVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIK--IWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
             VKQ  S K  R  + G   DLL ++ ++ P      + K D   +  +P S+    G   + L K  KK   + FG    V++     + ++K VPL++  C   +E  GL   GIYRV G N  +S L + +     +K   ES+I+   W  L+  + L+K     F  +P+   +    ++S+ +E   +++  +      +L +  PS Y                        TLR+++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  + + AE
Sbjct:  898 GVKQETSPKGSR--SLGIRPDLLWTSGVSAP-----RSPKQDGAAKEEAPPSK----GAWGINLMKKNKKCPPRAFG----VRLEDCQPAAENKGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHL-----NKGLSESNIQDQRWQDLNVVSSLLKSF---FRKLPEP--LFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYE----------------------TLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFSEEQEKAE 1164

HSP 2 Score: 56.6102 bits (135), Expect = 3.655e-7
Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 2 
Query: 1613 EGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDE-WFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +GVPL V LC S +E+ GL  +GIYR  GN     +L++  +N+   + +  D+ W +++ V+SL KS  RK    L   D           ++ +   D  ++++ +  +I  L   +            ++T +F+++HL  +    E  KM   NLAL F   L+
Sbjct:  976 KGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQE-HLNKGLSESNIQDQRWQDLNVVSSLLKSFFRKLPEPLFTDDKYSDF------IEANRMEDSRERMKMLRKLIKELPSYY------------YETLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLV 1124
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Match: ARHGAP23 (Rho GTPase activating protein 23 [Source:NCBI gene;Acc:100496640])

HSP 1 Score: 73.1738 bits (178), Expect = 3.256e-12
Identity = 84/314 (26.75%), Postives = 141/314 (44.90%), Query Frame = 2 
Query: 2474 SVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIK--IWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
             VKQ  S K  R  + G   DLL ++ ++ P      + K D   +  +P S+    G   + L K  KK   + FG    V++     + ++K VPL++  C   +E  GL   GIYRV G N  +S L + +     +K   ES+I+   W  L+  + L+K     F  +P+   +    ++S+ +E   +++  +      +L +  PS Y                        TLR+++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  + + AE
Sbjct:  952 GVKQETSPKGSR--SLGIRPDLLWTSGVSAP-----RSPKQDGAAKEEAPPSK----GAWGINLMKKNKKCPPRAFG----VRLEDCQPAAENKGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHL-----NKGLSESNIQDQRWQDLNVVSSLLKSF---FRKLPEP--LFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYE----------------------TLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFSEEQEKAE 1218

HSP 2 Score: 56.6102 bits (135), Expect = 3.803e-7
Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 2 
Query: 1613 EGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDE-WFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +GVPL V LC S +E+ GL  +GIYR  GN     +L++  +N+   + +  D+ W +++ V+SL KS  RK    L   D           ++ +   D  ++++ +  +I  L   +            ++T +F+++HL  +    E  KM   NLAL F   L+
Sbjct: 1030 KGVPLIVELCCSQVEQKGLEYLGIYRVPGNNAVVSSLQE-HLNKGLSESNIQDQRWQDLNVVSSLLKSFFRKLPEPLFTDDKYSDF------IEANRMEDSRERMKMLRKLIKELPSYY------------YETLRFLVRHLKTIADHSEKNKMEPRNLALVFGPTLV 1178
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Match: Arhgap23 (Rho GTPase activating protein 23 [Source:MGI Symbol;Acc:MGI:3697726])

HSP 1 Score: 71.2478 bits (173), Expect = 6.748e-12
Identity = 61/242 (25.21%), Postives = 111/242 (45.87%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWD 3388
            K  KKA  + FG    +++     + +++ VPL++ AC  I+E  GL   GIYRV G N  +S L + + +  +D   ++     W  L+  + L+K     F  +P+   +    ++++ +E   +++  +      +L +  P  Y                        TL++++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  D
Sbjct:  383 KKNKKAAPRAFG----IRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPSDINLQDER---WQDLNVISSLLKAF---FRKLPEP--LFTDDKYNDFIEANRIEDSRERMKTLRKLIRDLPGHYYE----------------------TLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDD 590
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Match: Arhgap23 (Rho GTPase activating protein 23 [Source:MGI Symbol;Acc:MGI:3697726])

HSP 1 Score: 70.8626 bits (172), Expect = 1.240e-11
Identity = 60/247 (24.29%), Postives = 110/247 (44.53%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAE 3403
            K  KKA  + FG    +++     + +++ VPL++ AC  I+E  GL   GIYRV G N  +S L + + +  +D   ++     W  L+  +     +   F  +P+   +    ++++ +E   +++  +      +L +  P  Y                        TL++++ HLK ++ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F  D    E
Sbjct:  894 KKNKKAAPRAFG----IRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPSDINLQDER---WQDLNVIS---SLLKAFFRKLPEP--LFTDDKYNDFIEANRIEDSRERMKTLRKLIRDLPGHYYE----------------------TLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDDEDKGE 1106
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Match: Arhgap5 (Rho GTPase activating protein 5 [Source:MGI Symbol;Acc:MGI:1332637])

HSP 1 Score: 64.3142 bits (155), Expect = 1.257e-10
Identity = 57/210 (27.14%), Postives = 87/210 (41.43%), Query Frame = 2 
Query: 2753 KDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ-IVQLLIDHCDWIF 3379
            K +PL +  CV+ IE+ GL  +G+YRVSG   D    D +  + D D     +S+++     + A           LIP        S   E LE   + +  K   +H   E +K                  K+  + V     RYV+ HL  VS     N M  ++L++CF P LM  D+ +   +  TK  Q +V+  I  C + F
Sbjct:   11 KPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTD---QDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIPY-------SLHPELLEAAKIPD--KTERFHALKEIVK------------------KF--HPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 188
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Match: Chn1 (chimerin 1 [Source:MGI Symbol;Acc:MGI:1915674])

HSP 1 Score: 61.6178 bits (148), Expect = 6.412e-10
Identity = 54/210 (25.71%), Postives = 91/210 (43.33%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +       ++ ++P++    L  A   L      P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:   33 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIES-AKIMDPDEQLETLHEALRSL------PPAHCE----------------------TLRYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF 210
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Match: Chn1 (chimerin 1 [Source:MGI Symbol;Acc:MGI:1915674])

HSP 1 Score: 61.6178 bits (148), Expect = 6.412e-10
Identity = 54/210 (25.71%), Postives = 91/210 (43.33%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLH--STACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ--IVQLLIDHCDWIF 3379
            P+V+  C+  IE+ GL  +G+YRVSG +     ++ + M  D D    + S+ ++  ++  + A  +        LI  D +       ++ ++P++    L  A   L      P  +C                       TLRY++ HLK V+LHE +N M   +L + F P LM       M  +N    Q  +V+LLI + D +F
Sbjct:   33 PMVVDMCIREIESRGLNSEGLYRVSGFS---DLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIES-AKIMDPDEQLETLHEALRSL------PPAHCE----------------------TLRYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF 210
[Close]
BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Match: sp|Q9VX32|RG190_DROME (Rho GTPase-activating protein 190 OS=Drosophila melanogaster OX=7227 GN=RhoGAPp190 PE=1 SV=2)

HSP 1 Score: 71.2478 bits (173), Expect = 6.810e-11
Identity = 63/249 (25.30%), Postives = 109/249 (43.78%), Query Frame = 2 
Query: 2669 KNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINC----DESSFIKYLENRVRS------GTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYS--SNMVVINTKCIQIVQLLIDHCDWIF 3379
            K L ++ E QFG         L  + +  ++P+ +  CV+ IE  GL  +GIYRV G     + +D L  + + D  TE  ++ I     +TA                    +   FS++L P   K+++K       LE+I  S      K+N     D S  +  L++ ++         L+Y+ +H  HVS +   N M + +LA+C+ P L+  D++   +   +      IVQ +ID   ++F
Sbjct: 1341 KGLVESAEAQFG--------KLMITSEQGEIPIFLNKCVEFIEKEGLDSEGIYRVPGSR---AHVDMLFQRFEEDTNTEIDALDIPVNAVATA--------------------LKDFFSKRLPPLFSKDIIK------ELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF 1552
[Close]
BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Match: sp|P97393|RHG05_MOUSE (Rho GTPase-activating protein 5 OS=Mus musculus OX=10090 GN=Arhgap5 PE=1 SV=2)

HSP 1 Score: 63.929 bits (154), Expect = 1.248e-8
Identity = 57/210 (27.14%), Postives = 87/210 (41.43%), Query Frame = 2 
Query: 2753 KDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQ-IVQLLIDHCDWIF 3379
            K +PL +  CV+ IE+ GL  +G+YRVSG   D    D +  + D D     +S+++     + A           LIP        S   E LE   + +  K   +H   E +K                  K+  + V     RYV+ HL  VS     N M  ++L++CF P LM  D+ +   +  TK  Q +V+  I  C + F
Sbjct: 1271 KPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTD---QDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIP-------YSLHPELLEAAKIPD--KTERFHALKEIVK------------------KF--HPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFF 1448
[Close]
BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Match: sp|P34288|PAC1_CAEEL (GTPase-activating protein pac-1 OS=Caenorhabditis elegans OX=6239 GN=pac-1 PE=1 SV=4)

HSP 1 Score: 63.1586 bits (152), Expect = 1.788e-8
Identity = 57/198 (28.79%), Postives = 92/198 (46.46%), Query Frame = 2 
Query: 1556 PKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPD-----KWSSHD-EWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDE-STKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDD 2128
            P+P+   + ++  P  S  + VP+ V  C  +IE +G+  VGIYR  GN      L++ + N   D     K  S D  W +V+ V+SL K  LRK  L +  +  KL    +D +  ST  +   KL++++  +                +  +DT +F+I HL  +    +  KM   NLAL F  +++   P DD
Sbjct:  942 PQPVL-GVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDLSKVESLDPRWRDVNVVSSLLKMFLRK--LPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLLRKL---------------PRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV--RPSDD 1119
[Close]
BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Match: sp|A4IF90|RHG15_BOVIN (Rho GTPase-activating protein 15 OS=Bos taurus OX=9913 GN=ARHGAP15 PE=2 SV=1)

HSP 1 Score: 61.6178 bits (148), Expect = 3.729e-8
Identity = 59/209 (28.23%), Postives = 93/209 (44.50%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMH-MTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +E  GL VDGIYRVSG    I +L  ++  N  +K   + S   W  +H    +   +   F  +P+  + +    QF E ++ +D          + R+E IK               S ++ L    R  T++ +  HL  +    S+N M T+SL + F P L+  ED S NM V      QI +L++   D IF
Sbjct:  294 VPRFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIV--NQEEKLNLDDS--QWEDIH---VVTGALKMFFRDLPEPLFPYSFFEQFVEAIKKQD---------NNTRIEAIK---------------SLVQKLPPPNRD-TMKVLFGHLTKIVARASKNLMSTHSLGIVFGPTLLRAEDESGNMAVHMVYQNQIAELMLSAYDQIF 470
[Close]
BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Match: sp|Q6DFV3|RHG21_MOUSE (Rho GTPase-activating protein 21 OS=Mus musculus OX=10090 GN=Arhgap21 PE=1 SV=1)

HSP 1 Score: 60.4622 bits (145), Expect = 1.201e-7
Identity = 45/165 (27.27%), Postives = 73/165 (44.24%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V +C  L+EE GL   GIYR  GN     ++++ +     D     D+W +++ ++SL KS  RK    L   D           ++ + K D   +L+ +  +I+ L  +             F+T KF+  HL  +    E  KM   NLA+ F   L+
Sbjct: 1154 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADF------IEANRKEDPLDRLRTLKRLIHDLPEHH------------FETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLV 1300
[Close]
BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Match: A0A4W3K4R5 (Rho-GAP domain-containing protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 2.784e-10
Identity = 70/231 (30.30%), Postives = 101/231 (43.72%), Query Frame = 2 
Query: 2708 VPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLI-----MKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLM--EEDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            V G ++ TL    + ++VP  +  C+D +E  GL  DGIYRVSG    I +L  L+     +  D  +W +   I       + A  M        L+P +++ H  S              +K A    ++E IK  +  S  K N D               T+R +  HLK V  H   NRM   S+A+ F P LM  E+D+ SNM V      QIV+L++  CD IF
Sbjct:  151 VFGCRLETLC-DREKENVPKFVQLCIDAVEKRGLEADGIYRVSGNLATIQKLRFLVDHEEKLNMDDAQWEDVHVI-------TGALKMFFRELPEPLVPYNSFEHFVS-------------AIKIADAAEKVESIK-QLVWSLPKPNQD---------------TMRVMFRHLKKVVEHSEANRMTAQSIAIVFGPTLMRSEKDF-SNMAVHMVYQNQIVELILVECDGIF 343
[Close]
BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Match: A0A4W3KGJ0 (Uncharacterized protein OS=Callorhinchus milii OX=7868 PE=4 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 7.178e-10
Identity = 69/231 (29.87%), Postives = 102/231 (44.16%), Query Frame = 2 
Query: 2708 VPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLI-----MKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLM--EEDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            V G ++ TL    + ++VP  +  C+D +E  GL  DGIYRVSG    I +L  L+     +  D  +W +   I       + A  M        L+P +++ H  S  ++  E               ++E IK  ++ S  K N D               T+R +  HLK V  H   NRM   S+A+ F P LM  E+D+ SNM V      QIV+L++  CD IF
Sbjct:  182 VFGCRLETLC-DREKENVPKFVQLCIDAVEKRGLEADGIYRVSGNLATIQKLRFLVDHEEKLNMDDAQWEDVHVI-------TGALKMFFRELPEPLVPYNSFEHFVSAITDAAE---------------KVESIKQLVW-SLPKPNQD---------------TMRVMFRHLKKVVEHSEANRMTAQSIAIVFGPTLMRSEKDF-SNMAVHMVYQNQIVELILVECDGIF 372
[Close]
BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Match: A0A401NJL6 (Uncharacterized protein (Fragment) OS=Scyliorhinus torazame OX=75743 GN=scyTo_0009278 PE=4 SV=1)

HSP 1 Score: 75.8702 bits (185), Expect = 8.073e-10
Identity = 70/240 (29.17%), Postives = 113/240 (47.08%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWD 3388
            +KK K+   G   GV++       ++K +PL++  C  ++E  GL   GIYRV G N  +S L + + K  TD  T E     W  L+  +     +   F  +P+   +    ++++ +E     N L+ AA   RL++ K  +       N  E+    YLE      TL+++  HLK V+ H  +N+M   +LA+ F P L+   ED   +MV       +I++ LI H DW F  D
Sbjct:  587 MKKTKKTVSGAAFGVRLEECQPGVNNKFIPLIVEICCKLVEEKGLEYTGIYRVPGNNAMVSSLQEQLNKGMTDLNTSEEK---WQDLNVISS---LLKLFFRKLPEP--LFTDDKYNDFIE----TNRLEDAAE--RLQRFKKLLR------NLPEN----YLE------TLKFLTGHLKTVADHSEKNKMEPRNLALVFGPTLVRTSEDKMIDMVTHMQDRYKIIETLIQHYDWFFNED 796
[Close]
BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Match: A0A3B3C1Q0 (Rho GTPase activating protein 23b OS=Oryzias melastigma OX=30732 PE=4 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 8.510e-10
Identity = 70/254 (27.56%), Postives = 116/254 (45.67%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFK-----WDFKPAEDIYG 3415
            +KKAK+       G+++     + +HK VPL++  C  ++E  GL   GIYRV G N  +S L + + K      TEE     W  L+    +   +   F  +P+   +    ++S+ +E   +K+  +      RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F       D K  ED  G
Sbjct:  850 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCGVVETTGLEYTGIYRVPGNNAMVSNLQEHLNKGLDINTTEER----WQDLN---VISSLLKSFFRKLPEP--LFTDDKYSDFIEANRIKDTEE------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFFSDADLDQDEKAPEDKQG 1072
[Close]
BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Match: A0A3B3C1K7 (Rho GTPase activating protein 23b OS=Oryzias melastigma OX=30732 PE=4 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 8.972e-10
Identity = 70/254 (27.56%), Postives = 116/254 (45.67%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIFK-----WDFKPAEDIYG 3415
            +KKAK+       G+++     + +HK VPL++  C  ++E  GL   GIYRV G N  +S L + + K      TEE     W  L+    +   +   F  +P+   +    ++S+ +E   +K+  +      RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F       D K  ED  G
Sbjct:  863 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCGVVETTGLEYTGIYRVPGNNAMVSNLQEHLNKGLDINTTEER----WQDLN---VISSLLKSFFRKLPEP--LFTDDKYSDFIEANRIKDTEE------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFFSDADLDQDEKAPEDKQG 1085
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Match: arhgap12b (Rho GTPase activating protein 12 [Source:NCBI gene;Acc:103034428])

HSP 1 Score: 65.4698 bits (158), Expect = 3.286e-10
Identity = 59/208 (28.37%), Postives = 94/208 (45.19%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL +DG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +          D  N +K + Y  RL+ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  641 VPNFVKMCIEHVENTGLNIDGLYRVSG-NLAVIQKLRFAVNHDEQVDLDDSK---WEDIHVTTG---ALKMFFRELPEPLFTYASFN--------DFVNAIKHSDYKQRLQGIK---------------DLIKQLP-KPNQETMQVLFKHLKRVIDHGEANRMTTQSVAIVFGPTLLRPETETGNMAVHMVYQNQIVELILLEYENIF 817
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Match: arhgap12b (Rho GTPase activating protein 12 [Source:NCBI gene;Acc:103034428])

HSP 1 Score: 65.4698 bits (158), Expect = 3.389e-10
Identity = 59/208 (28.37%), Postives = 94/208 (45.19%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL +DG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +          D  N +K + Y  RL+ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  665 VPNFVKMCIEHVENTGLNIDGLYRVSG-NLAVIQKLRFAVNHDEQVDLDDSK---WEDIHVTTG---ALKMFFRELPEPLFTYASFN--------DFVNAIKHSDYKQRLQGIK---------------DLIKQLP-KPNQETMQVLFKHLKRVIDHGEANRMTTQSVAIVFGPTLLRPETETGNMAVHMVYQNQIVELILLEYENIF 841
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Match: arhgap12b (Rho GTPase activating protein 12 [Source:NCBI gene;Acc:103034428])

HSP 1 Score: 65.4698 bits (158), Expect = 3.405e-10
Identity = 59/208 (28.37%), Postives = 94/208 (45.19%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL +DG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +          D  N +K + Y  RL+ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  690 VPNFVKMCIEHVENTGLNIDGLYRVSG-NLAVIQKLRFAVNHDEQVDLDDSK---WEDIHVTTG---ALKMFFRELPEPLFTYASFN--------DFVNAIKHSDYKQRLQGIK---------------DLIKQLP-KPNQETMQVLFKHLKRVIDHGEANRMTTQSVAIVFGPTLLRPETETGNMAVHMVYQNQIVELILLEYENIF 866
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Match: arhgap12b (Rho GTPase activating protein 12 [Source:NCBI gene;Acc:103034428])

HSP 1 Score: 65.4698 bits (158), Expect = 3.416e-10
Identity = 59/208 (28.37%), Postives = 94/208 (45.19%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL +DG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +          D  N +K + Y  RL+ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  731 VPNFVKMCIEHVENTGLNIDGLYRVSG-NLAVIQKLRFAVNHDEQVDLDDSK---WEDIHVTTG---ALKMFFRELPEPLFTYASFN--------DFVNAIKHSDYKQRLQGIK---------------DLIKQLP-KPNQETMQVLFKHLKRVIDHGEANRMTTQSVAIVFGPTLLRPETETGNMAVHMVYQNQIVELILLEYENIF 907
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Match: arhgap12b (Rho GTPase activating protein 12 [Source:NCBI gene;Acc:103034428])

HSP 1 Score: 65.4698 bits (158), Expect = 3.459e-10
Identity = 59/208 (28.37%), Postives = 94/208 (45.19%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VP  +  C++ +EN GL +DG+YRVSG N  + Q  +  + +D     ++S    W  +H T      +   F  +P+  + + +          D  N +K + Y  RL+ IK                 IK L  +    T++ + +HLK V  H   NRM T S+A+ F P L+  E  + NM V      QIV+L++   + IF
Sbjct:  614 VPNFVKMCIEHVENTGLNIDGLYRVSG-NLAVIQKLRFAVNHDEQVDLDDSK---WEDIHVTTG---ALKMFFRELPEPLFTYASFN--------DFVNAIKHSDYKQRLQGIK---------------DLIKQLP-KPNQETMQVLFKHLKRVIDHGEANRMTTQSVAIVFGPTLLRPETETGNMAVHMVYQNQIVELILLEYENIF 790
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Sea Lamprey
Match: arhgap5 (Rho GTPase activating protein 5 [Source:ZFIN;Acc:ZDB-GENE-081014-1])

HSP 1 Score: 70.0922 bits (170), Expect = 3.884e-12
Identity = 58/192 (30.21%), Postives = 88/192 (45.83%), Query Frame = 2 
Query: 1517 DNPRPEPRKFKQSPKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCF 2092
            D P+P   K K  PK     L L  LP S   + VP+F+  C   IE  GL   G+YR SGN  D+  ++ +   ++   + S     +VH+V    KS            A+   +I  +  +S    V   +++  DMI  L       V  +  +  +D FKFII HL+R+    +  KM +ENL++CF
Sbjct: 1231 DTPKPPKAKTKSVPKVSYFGLPLKDLPLSP-TKAVPVFIDKCVDFIEMNGLDTEGLYRVSGNKADQENIQLLFGQDHTVDFRSLG--ISVHSVTGALKSFF---------TALPEPLIPYEQQKSLADAVG--IENEKDMITALQ-----DVVKKLPQIHYDVFKFIITHLHRVYQHNQNNKMTSENLSICF 1403
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Sea Lamprey
Match: ARHGAP15 (Rho GTPase activating protein 15 [Source:HGNC Symbol;Acc:HGNC:21030])

HSP 1 Score: 55.4546 bits (132), Expect = 8.183e-8
Identity = 57/217 (26.27%), Postives = 87/217 (40.09%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKN-----DTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEP----EDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDY-SSNMVVINTKCIQIVQLLIDHCDWIF 3379
            VPL +  C+  +E   L +DG+YRVSG    I +L  ++  +     D  +W + + I     L                           +  E L P    E     +K   YH R++       C +  IN      I  L N     T+++++ HLK V  H  +NRM   ++A+ F P L+  +    NM V      QIV L++  CD IF
Sbjct:  621 VPLFVRMCMIALEWQRLEIDGVYRVSGNQATIQKLRIMVDHDEHVDLDDSQWEDINVITGALKL------------------------FFRELPEPLVPYIFFEQFIAAIKIFEYHNRVK-------CMKDLIN------ILPLPNH---NTMKFLIRHLKTVVAHGEKNRMSMQNMAIVFAPTLLRPEVDPGNMAVHMVYQNQIVDLILGECDNIF 797
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Sea Lamprey
Match: arhgap21b (Rho GTPase activating protein 21b [Source:ZFIN;Acc:ZDB-GENE-030131-4944])

HSP 1 Score: 50.0618 bits (118), Expect = 4.991e-6
Identity = 42/163 (25.77%), Postives = 75/163 (46.01%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V +C  L+EE GL   GIYR  GN     +L++ +     +  ++ D+W +++ ++SL KS  RK   L + +       +  +D +   +  ++L+ +  +I+ L             +  F T KF+  HL  +       KM   NLA+ F   L+
Sbjct: 1022 LPLIVEVCCGLVEERGLESTGIYRVPGNNAAVCSLQEELNRGVTEIDTNDDKWRDLNVISSLLKSFFRK---LPEPLFTDEKYYEF-IDANRMENGVERLKALKKLIHELP------------EHHFHTLKFLSMHLKTIAENSPKNKMEPRNLAIVFGPTLV 1168
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Yeast
Match: BEM2 (Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p [Source:SGD;Acc:S000000957])

HSP 1 Score: 50.447 bits (119), Expect = 2.247e-6
Identity = 47/175 (26.86%), Postives = 75/175 (42.86%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS---SHDEWFNVHTVASLFKSTLRK-------YTLLDK--DMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +P  VV     IE  GL +VG+YR  G++     L++    E     S     D WF V+ +A  FK  LR+       + +++   D+AIK     + V+E  K  +++ LQ +                     C + T K I+ HL ++       KM+A NLA+ F  + I
Sbjct: 1980 IPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAM-VNEEYKRMMNELLQKLP-------------------TCYYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMSFI 2134
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Nematostella
Match: EDO31406 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SY14])

HSP 1 Score: 54.6842 bits (130), Expect = 1.963e-7
Identity = 55/221 (24.89%), Postives = 94/221 (42.53%), Query Frame = 2 
Query: 2762 PLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMH-MTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME-----------EDYSSNMVVINTKCIQIVQLLIDHCDWIFKWD 3388
            PLV+  C  +IE  G+ VDGIYR+SG +  I +L  L   ++  +  +E  ++         C+   +   F  +P     + +  +F   ++  D K   +  A H  ++Q+ P  Y                        TL Y+L+HL  V+ H  Q  M   +LA+ + P L++           E  S+ ++ IN + I IV+ LI +   +F  D
Sbjct:  293 PLVLEKCAAVIEEHGI-VDGIYRLSGSSSIIQKLRFLFDGDEPPELDDEYYLR------DVHCISSLLKMYFRELPNPLLTYSLYDKFVSAIQITDEKE--RKVAIHHVVQQLPPPHY-----------------------RTLEYLLQHLAKVASHAGQTAMHAKNLAIVWAPNLLKPRSQVRITIIYEYGSTALLEINVQAI-IVEYLIRNAAELFDRD 480

HSP 2 Score: 50.0618 bits (118), Expect = 6.395e-6
Identity = 45/171 (26.32%), Postives = 81/171 (47.37%), Query Frame = 2 
Query: 1622 PLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWF--NVHTVASLFKSTLRK-------YTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            PL +  CA++IEE G+ D GIYR SG+    + L  +   + P +    DE++  +VH ++SL K   R+       Y+L DK     +S I++  ++  K  +   +Q +    Y                    T +++++HL ++      T M+A+NLA+ +  NL+
Sbjct:  293 PLVLEKCAAVIEEHGIVD-GIYRLSGSSSIIQKLRFLFDGDEPPELD--DEYYLRDVHCISSLLKMYFRELPNPLLTYSLYDK----FVSAIQITDEKERKVAIHHVVQQLPPPHYR-------------------TLEYLLQHLAKVASHAGQTAMHAKNLAIVWAPNLL 437
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Nematostella
Match: EDO49053 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHX5])

HSP 1 Score: 53.5286 bits (127), Expect = 6.063e-7
Identity = 58/199 (29.15%), Postives = 85/199 (42.71%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDI-----PVDDVIQIKESRAIVAQENLTKM-VCFW 2197
            VP  VV C S IE+ GL +VG+YR  G     + L+D  ++    K  +  E  ++H V  + K  LR       +  +   +    V+ + K D     QD    +Y        AVS E  +   DT   ++ HL ++  C +  KM   NLA  F   L+G       PVD + Q K    +V  E L  M V +W
Sbjct:  382 VPAIVVQCISEIEKRGLNEVGLYRVPGAERSIKELKDKFLH---GKTQNLHETIDIHVVCGVLKDFLRNLA----EPLVTYHLWGAFVNAANKDDD----QDSFSAMYQ-------AVS-ELPQANRDTLACLVVHLQKVSQCTD-CKMPVSNLARVFGPTLVGHSSPNVEPVDMLQQTKLQPRVV--ERLLAMPVDYW 558
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Nematostella
Match: EDO44981 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUA5])

HSP 1 Score: 50.8322 bits (120), Expect = 4.836e-6
Identity = 42/155 (27.10%), Postives = 70/155 (45.16%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLA 2083
            VPLFV  C   +E  G+   GIYRKSG + D RT+++    +    +S+ +   NVH V       L+K+  L  +  I  ++    +D +   D D++L  +  ++  L             K  F   K+++ HL R+    +   M + NLA
Sbjct: 1537 VPLFVEKCIDFVEAEGMQIEGIYRKSGKIEDIRTIQNSFDEKRDADFSALE--MNVHAVT----GALKKFLKLLPEPLIPNNLQNNILDATVIMDADERLAVLRGLVMQLP------------KVNFAVLKYLMCHLNRVTEYSKENLMESRNLA 1673
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Nematostella
Match: EDO38242 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDK1])

HSP 1 Score: 48.1358 bits (113), Expect = 5.054e-6
Identity = 50/175 (28.57%), Postives = 79/175 (45.14%), Query Frame = 2 
Query: 1580 ILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS-SHDEWFNVHTVASLFKSTLRKY--TLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFV 2095
            + S L QSS    VPL V  C   IE+ GL  VG+YR SGN   K+ L     +EN +    S +   +++ +  + K  LR+    L+ + M   L   K   +E     VD++ Q + +++  L    +             T  FI+ HL  +   +E  KM+A NL++C  
Sbjct:   32 VTSELEQSS----VPLLVRKCVLEIEKRGLESVGLYRISGNARRKKELRG-FFDENSEAVDISEENCPDINVITGILKDYLRELPEPLITEKMTEGLR--KAAKNEIQDKKVDEQKQVMSELLSGLPDPNRH------------TLVFILNHLRHVMEKKEFNKMDARNLSVCLA 187
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Match: ENSORLT00000035543.1 (rho GTPase-activating protein 23 [Source:NCBI gene;Acc:101173450])

HSP 1 Score: 75.8702 bits (185), Expect = 2.925e-13
Identity = 64/237 (27.00%), Postives = 110/237 (46.41%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            +KKAK+       G+++     + +HK VPL++  C +++E  GL   GIYRV G N  +S L + + K      TEE     W  L+    +   +   F  +P+   +    ++ + ++   +KN         RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F
Sbjct:  751 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQEHLNKGLNINITEER----WQDLN---VISSLLKSFFRKLPEP--LFTDDKYGDFIDANRIKNTED------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFF 956

HSP 2 Score: 56.225 bits (134), Expect = 2.882e-7
Identity = 44/166 (26.51%), Postives = 70/166 (42.17%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYT---LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            VPL V +C  ++E  GL   GIYR  GN      L++  +N+  +   + + W +++ ++SL KS  RK       D      +   ++   E     + K + D+ D  +H                   T KF++ HL R+    E  KM   NLAL F   L+
Sbjct:  779 VPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQE-HLNKGLNINITEERWQDLNVISSLLKSFFRKLPEPLFTDDKYGDFIDANRIKNTEDRLKTMKKLIHDLPDYYHH-------------------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLV 924
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Match: ENSORLT00000032335.1 (rho GTPase-activating protein 23 [Source:NCBI gene;Acc:101173450])

HSP 1 Score: 75.485 bits (184), Expect = 3.607e-13
Identity = 64/237 (27.00%), Postives = 110/237 (46.41%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            +KKAK+       G+++     + +HK VPL++  C +++E  GL   GIYRV G N  +S L + + K      TEE     W  L+    +   +   F  +P+   +    ++ + ++   +KN         RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F
Sbjct:  852 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQEHLNKGLNINITEER----WQDLN---VISSLLKSFFRKLPEP--LFTDDKYGDFIDANRIKNTED------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFF 1057

HSP 2 Score: 56.225 bits (134), Expect = 3.052e-7
Identity = 44/166 (26.51%), Postives = 70/166 (42.17%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYT---LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            VPL V +C  ++E  GL   GIYR  GN      L++  +N+  +   + + W +++ ++SL KS  RK       D      +   ++   E     + K + D+ D  +H                   T KF++ HL R+    E  KM   NLAL F   L+
Sbjct:  880 VPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQE-HLNKGLNINITEERWQDLNVISSLLKSFFRKLPEPLFTDDKYGDFIDANRIKNTEDRLKTMKKLIHDLPDYYHH-------------------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLV 1025
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Match: ENSORLT00000045586.1 (rho GTPase-activating protein 23 [Source:NCBI gene;Acc:101173450])

HSP 1 Score: 75.485 bits (184), Expect = 4.006e-13
Identity = 64/237 (27.00%), Postives = 110/237 (46.41%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            +KKAK+       G+++     + +HK VPL++  C +++E  GL   GIYRV G N  +S L + + K      TEE     W  L+    +   +   F  +P+   +    ++ + ++   +KN         RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F
Sbjct:  869 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQEHLNKGLNINITEER----WQDLN---VISSLLKSFFRKLPEP--LFTDDKYGDFIDANRIKNTED------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFF 1074

HSP 2 Score: 56.225 bits (134), Expect = 3.191e-7
Identity = 44/166 (26.51%), Postives = 70/166 (42.17%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYT---LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            VPL V +C  ++E  GL   GIYR  GN      L++  +N+  +   + + W +++ ++SL KS  RK       D      +   ++   E     + K + D+ D  +H                   T KF++ HL R+    E  KM   NLAL F   L+
Sbjct:  897 VPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQE-HLNKGLNINITEERWQDLNVISSLLKSFFRKLPEPLFTDDKYGDFIDANRIKNTEDRLKTMKKLIHDLPDYYHH-------------------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLV 1042
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Match: ENSORLT00000036475.1 (rho GTPase-activating protein 23 [Source:NCBI gene;Acc:101173450])

HSP 1 Score: 75.0998 bits (183), Expect = 4.392e-13
Identity = 64/237 (27.00%), Postives = 110/237 (46.41%), Query Frame = 2 
Query: 2675 LKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLME--EDYSSNMVVINTKCIQIVQLLIDHCDWIF 3379
            +KKAK+       G+++     + +HK VPL++  C +++E  GL   GIYRV G N  +S L + + K      TEE     W  L+  +     +   F  +P+   +    ++ + ++   +KN         RL+ +K        K+  D   +  +        TL++++ HLK V+ H  +N+M   +LA+ F P L+   ED  ++MV       +IV+ LI H DW F
Sbjct:  856 MKKAKKTSSPKAFGIRLEDCQPAVNHKFVPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQEHLNKGLNINITEER----WQDLNVIS---SLLKSFFRKLPEP--LFTDDKYGDFIDANRIKNTED------RLKTMK--------KLIHDLPDYYHH--------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIVHHDWFF 1061

HSP 2 Score: 55.8398 bits (133), Expect = 3.566e-7
Identity = 44/166 (26.51%), Postives = 70/166 (42.17%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYT---LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            VPL V +C  ++E  GL   GIYR  GN      L++  +N+  +   + + W +++ ++SL KS  RK       D      +   ++   E     + K + D+ D  +H                   T KF++ HL R+    E  KM   NLAL F   L+
Sbjct:  884 VPLIVEMCCEVVETIGLEYTGIYRVPGNNAMVSNLQE-HLNKGLNINITEERWQDLNVISSLLKSFFRKLPEPLFTDDKYGDFIDANRIKNTEDRLKTMKKLIHDLPDYYHH-------------------TLKFLVGHLKRVADHSEKNKMEPRNLALVFGPTLV 1029
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Match: arhgap21b (rho GTPase-activating protein 21 [Source:NCBI gene;Acc:101162320])

HSP 1 Score: 62.7734 bits (151), Expect = 2.945e-9
Identity = 56/194 (28.87%), Postives = 91/194 (46.91%), Query Frame = 2 
Query: 1547 KQSPKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNEN-PDKWSSHDEWFNVHTVASLFKSTLRK-----YTLLDKDMAIKLSIIKLDVDESTKT-DVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            K++P  IT ++ L   P S   E VPL V LC +++EE GL   GIYR  G      ++++ + ++   D     ++W ++  ++SL K   RK     +T    D  I          E++KT D  ++L+++  ++Y L             K  F+T KF+  HL R+    E  KM   NLA+ F   L+
Sbjct:  854 KKTPAGITFEIRLEDCPPSKSNEFVPLIVELCCNIVEERGLEFTGIYRVPGKKAAISSMQEELNSKGMADIDIQEEKWQDLSVISSLLKLFFRKLPEPLFTNEKYDEFI----------EASKTEDPVERLKNLKRLVYEL------------PKHHFETLKFLCAHLKRVSDNCEKNKMEPRNLAIMFGPTLV 1025
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Match: SMESG000012042.1 (SMESG000012042.1)

HSP 1 Score: 2316.96 bits (6003), Expect = 0.000e+0
Identity = 1175/1188 (98.91%), Postives = 1180/1188 (99.33%), Query Frame = 2 
Query:   80 MAELKVSLNNISGKGYGIKVEKCDSRKDGLVIVSMDADSQASVKGLKVGDKIIRVNNKSTESCRNKLISELHDSKSNHVLLTIKRNLKDLRHQSDKNLSSSVCSLNASFQSMFRNSKSSIDLKCSYQPLSKILDSNYVTENHINEFFQDEPNDTVDNSYLGPQSNEKSNIYLEDSDSNPGSRKQSTCVPPSPSNVQLTRKKAYKKSVDETENIYQSQQPKINRKKATNTLNNSKESVPVVTVKRRTNQVVDNNSFVYRNYSTNRXXXXXXXXXXXXXXXXXXXXXXXXXXATPSEIPISIQPLYNTYESVDGSMHSRLKTNLIKETTSLKEINSLPTSIECEMKIISFIDKKIAKPTWKIYWMEIDFTGVHFQCSELSQTQVSSNSTALNPSIVNPELIMNVWEVNNNMTKFYLPIFQSPYDEQIIRSTTLDEIKISFPQKVEFSIKLTEENTIKLCQMLKVPEIKNPPIKHKKSVVSVDNPRPEPRKFKQSPKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDDVIQIKESRAIVAQENLTKMVCFWITYAEVMCXXXXXXXXXXXPGMIKDFLNQKNFNNNLCQMPNNNEYKTEIDRQKLIRERIEYHTENVNASNLNSSPRTPESYFSRTKNSRLYQSVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKDSNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLENI 3643
            MAELKVSLNNISGKGYGIKVEKCDSRKDGLVIVSMDADSQASVKGLKVGDKIIRVNNKSTESCRNKLISELHDSKSNHVLLTIKRNLKDLRHQSDKNLSSSVCSLNA+FQSMFRNSKSSIDLKCSYQPLSKILDSNYVTENHINEFFQDEPND VD+SYLGPQSNEKSNIYLEDSDSNPGSRKQSTCVPPSPSNVQLTRKKAYKKSVDETENIYQSQQPKINRKKATNTLNNSKESVPVVTVKRRTNQVVDNNSFVYRNYSTNRSLKPICSSPLSKPLSIIPSSFSNSSLATPSE PI IQPLYNTYESVDGSMHSR K NLIKETTSLKEINSLPTSIECEMKIISFIDKKIAKPTWKIYWMEIDFTGVHFQCSELSQTQVSSNSTALNPSIVNPELIMNVWEVNNNMTKFYLPIFQSPYDEQIIRSTTLDEIKISFPQKVEFSIKLTEENTIKLCQMLKVPEIKNPPIKHKKSVVSVDNPRPEPRKFKQSPKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDDVIQIKESRAIVAQENLTKMVCFWITYAEVMCELLEEQKEEELP MIKDFLNQKNFNNNLCQMPNNNEYK EIDRQKLIRERIEYHTENVNASNLN SPRTPESYFSRTKNSRLYQSVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPG+KMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACLMKKMLKKFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLE+IKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKP+EDIYGQMMSDDLEKHLKEYRPIPCQCDKAKDSNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLENI
Sbjct:    1 MAELKVSLNNISGKGYGIKVEKCDSRKDGLVIVSMDADSQASVKGLKVGDKIIRVNNKSTESCRNKLISELHDSKSNHVLLTIKRNLKDLRHQSDKNLSSSVCSLNANFQSMFRNSKSSIDLKCSYQPLSKILDSNYVTENHINEFFQDEPNDAVDSSYLGPQSNEKSNIYLEDSDSNPGSRKQSTCVPPSPSNVQLTRKKAYKKSVDETENIYQSQQPKINRKKATNTLNNSKESVPVVTVKRRTNQVVDNNSFVYRNYSTNRSLKPICSSPLSKPLSIIPSSFSNSSLATPSESPICIQPLYNTYESVDGSMHSRPKANLIKETTSLKEINSLPTSIECEMKIISFIDKKIAKPTWKIYWMEIDFTGVHFQCSELSQTQVSSNSTALNPSIVNPELIMNVWEVNNNMTKFYLPIFQSPYDEQIIRSTTLDEIKISFPQKVEFSIKLTEENTIKLCQMLKVPEIKNPPIKHKKSVVSVDNPRPEPRKFKQSPKPITEKLILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLIGDIPVDDVIQIKESRAIVAQENLTKMVCFWITYAEVMCELLEEQKEEELPRMIKDFLNQKNFNNNLCQMPNNNEYKNEIDRQKLIRERIEYHTENVNASNLNRSPRTPESYFSRTKNSRLYQSVKQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMSQRLFTGVGDLRLNKNLKKAKEQQFGFVPGIKMTTLYFSGDHKDVPLVITACVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWATLHSTACLMKKMLKKFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEKIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQIVQLLIDHCDWIFKWDFKPSEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKDSNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLENI 1188
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Match: SMESG000066536.1 (SMESG000066536.1)

HSP 1 Score: 83.5741 bits (205), Expect = 8.217e-16
Identity = 76/304 (25.00%), Postives = 131/304 (43.09%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGR----NYDISQLDQLIMKND--TDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVIN--TKCIQIVQLLIDHCDWIFKWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKD--SNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLEN 3640
            +PL +  C+ IIEN+G+   G+YRVSG     +Y  ++L + + + D  TDKW +  +I       S             L PKD +  +      ++   D +  L      L +++    M  +Q            + E R    TLRY++EHL  V+  ++ N+M   +LAV F P LM+    +N +++N     IQ+++ LI H  W+F    + A ++   +  +DL+    +  P P +    KD  +        +KE+L K                + +  + NFEN+    N
Sbjct:  794 IPLTVELCISIIENYGMNHVGLYRVSGNKIALDYICAELRKPVSEIDVQTDKWNDLHAI-------SGVLKSFFRNLSDGLFPKDLYSDIIGAC--RMHEGDRERRL------LSIQRFLSIMDIAQD-----------HPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLMKPPQETNEILVNDYKYKIQLIEALIKHHKWLFSPTLESACNVPPDIDDEDLKSTPSDDLPFPIELYDNKDIVTGVTDARPLVKEILEK----------------VKFISKDNFENLENFSN 1055

HSP 2 Score: 67.0106 bits (162), Expect = 1.143e-10
Identity = 49/169 (28.99%), Postives = 83/169 (49.11%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS----SHDEWFNVHTVASLFKSTLRKYT--LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V LC S+IE +G+  VG+YR SGN    +   D I  E     S      D+W ++H ++ + KS  R  +  L  KD+   +    +      + D +++L  I   +  ++     A    E +   +T +++++HL R+   Q T KMNA+NLA+ F   L+
Sbjct:  794 IPLTVELCISIIENYGMNHVGLYRVSGN----KIALDYICAELRKPVSEIDVQTDKWNDLHAISGVLKSFFRNLSDGLFPKDLYSDI----IGACRMHEGDRERRLLSIQRFLSIMDI----AQDHPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLM 950
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Match: SMESG000066536.1 (SMESG000066536.1)

HSP 1 Score: 83.5741 bits (205), Expect = 8.457e-16
Identity = 76/304 (25.00%), Postives = 131/304 (43.09%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGR----NYDISQLDQLIMKND--TDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVIN--TKCIQIVQLLIDHCDWIFKWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKD--SNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLEN 3640
            +PL +  C+ IIEN+G+   G+YRVSG     +Y  ++L + + + D  TDKW +  +I       S             L PKD +  +      ++   D +  L      L +++    M  +Q            + E R    TLRY++EHL  V+  ++ N+M   +LAV F P LM+    +N +++N     IQ+++ LI H  W+F    + A ++   +  +DL+    +  P P +    KD  +        +KE+L K                + +  + NFEN+    N
Sbjct:  795 IPLTVELCISIIENYGMNHVGLYRVSGNKIALDYICAELRKPVSEIDVQTDKWNDLHAI-------SGVLKSFFRNLSDGLFPKDLYSDIIGAC--RMHEGDRERRL------LSIQRFLSIMDIAQD-----------HPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLMKPPQETNEILVNDYKYKIQLIEALIKHHKWLFSPTLESACNVPPDIDDEDLKSTPSDDLPFPIELYDNKDIVTGVTDARPLVKEILEK----------------VKFISKDNFENLENFSN 1056

HSP 2 Score: 66.6254 bits (161), Expect = 1.198e-10
Identity = 49/169 (28.99%), Postives = 83/169 (49.11%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS----SHDEWFNVHTVASLFKSTLRKYT--LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V LC S+IE +G+  VG+YR SGN    +   D I  E     S      D+W ++H ++ + KS  R  +  L  KD+   +    +      + D +++L  I   +  ++     A    E +   +T +++++HL R+   Q T KMNA+NLA+ F   L+
Sbjct:  795 IPLTVELCISIIENYGMNHVGLYRVSGN----KIALDYICAELRKPVSEIDVQTDKWNDLHAISGVLKSFFRNLSDGLFPKDLYSDI----IGACRMHEGDRERRLLSIQRFLSIMDI----AQDHPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLM 951
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Match: SMESG000066536.1 (SMESG000066536.1)

HSP 1 Score: 83.5741 bits (205), Expect = 8.796e-16
Identity = 76/304 (25.00%), Postives = 131/304 (43.09%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGR----NYDISQLDQLIMKND--TDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVIN--TKCIQIVQLLIDHCDWIFKWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKD--SNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLEN 3640
            +PL +  C+ IIEN+G+   G+YRVSG     +Y  ++L + + + D  TDKW +  +I       S             L PKD +  +      ++   D +  L      L +++    M  +Q            + E R    TLRY++EHL  V+  ++ N+M   +LAV F P LM+    +N +++N     IQ+++ LI H  W+F    + A ++   +  +DL+    +  P P +    KD  +        +KE+L K                + +  + NFEN+    N
Sbjct:  795 IPLTVELCISIIENYGMNHVGLYRVSGNKIALDYICAELRKPVSEIDVQTDKWNDLHAI-------SGVLKSFFRNLSDGLFPKDLYSDIIGAC--RMHEGDRERRL------LSIQRFLSIMDIAQD-----------HPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLMKPPQETNEILVNDYKYKIQLIEALIKHHKWLFSPTLESACNVPPDIDDEDLKSTPSDDLPFPIELYDNKDIVTGVTDARPLVKEILEK----------------VKFISKDNFENLENFSN 1056

HSP 2 Score: 67.0106 bits (162), Expect = 1.143e-10
Identity = 49/169 (28.99%), Postives = 83/169 (49.11%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS----SHDEWFNVHTVASLFKSTLRKYT--LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V LC S+IE +G+  VG+YR SGN    +   D I  E     S      D+W ++H ++ + KS  R  +  L  KD+   +    +      + D +++L  I   +  ++     A    E +   +T +++++HL R+   Q T KMNA+NLA+ F   L+
Sbjct:  795 IPLTVELCISIIENYGMNHVGLYRVSGN----KIALDYICAELRKPVSEIDVQTDKWNDLHAISGVLKSFFRNLSDGLFPKDLYSDI----IGACRMHEGDRERRLLSIQRFLSIMDI----AQDHPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLM 951
[Close]
BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Match: SMESG000066536.1 (SMESG000066536.1)

HSP 1 Score: 83.5741 bits (205), Expect = 8.895e-16
Identity = 76/304 (25.00%), Postives = 131/304 (43.09%), Query Frame = 2 
Query: 2759 VPLVITACVDIIENFGLRVDGIYRVSGR----NYDISQLDQLIMKND--TDKWTEESSIKIWATLHSTACXXXXXXXXFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYHLRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLHESQNRMLTNSLAVCFVPVLMEEDYSSNMVVIN--TKCIQIVQLLIDHCDWIFKWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKD--SNYVANHNHIKELLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLEN 3640
            +PL +  C+ IIEN+G+   G+YRVSG     +Y  ++L + + + D  TDKW +  +I       S             L PKD +  +      ++   D +  L      L +++    M  +Q            + E R    TLRY++EHL  V+  ++ N+M   +LAV F P LM+    +N +++N     IQ+++ LI H  W+F    + A ++   +  +DL+    +  P P +    KD  +        +KE+L K                + +  + NFEN+    N
Sbjct:  794 IPLTVELCISIIENYGMNHVGLYRVSGNKIALDYICAELRKPVSEIDVQTDKWNDLHAI-------SGVLKSFFRNLSDGLFPKDLYSDIIGAC--RMHEGDRERRL------LSIQRFLSIMDIAQD-----------HPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLMKPPQETNEILVNDYKYKIQLIEALIKHHKWLFSPTLESACNVPPDIDDEDLKSTPSDDLPFPIELYDNKDIVTGVTDARPLVKEILEK----------------VKFISKDNFENLENFSN 1055

HSP 2 Score: 67.0106 bits (162), Expect = 1.168e-10
Identity = 49/169 (28.99%), Postives = 83/169 (49.11%), Query Frame = 2 
Query: 1619 VPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLEDVIMNENPDKWS----SHDEWFNVHTVASLFKSTLRKYT--LLDKDMAIKLSIIKLDVDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHLYRMQLCQETTKMNAENLALCFVNNLI 2107
            +PL V LC S+IE +G+  VG+YR SGN    +   D I  E     S      D+W ++H ++ + KS  R  +  L  KD+   +    +      + D +++L  I   +  ++     A    E +   +T +++++HL R+   Q T KMNA+NLA+ F   L+
Sbjct:  794 IPLTVELCISIIENYGMNHVGLYRVSGN----KIALDYICAELRKPVSEIDVQTDKWNDLHAISGVLKSFFRNLSDGLFPKDLYSDI----IGACRMHEGDRERRLLSIQRFLSIMDI----AQDHPEYRYHRETLRYLMEHLSRVASRQATNKMNAKNLAVIFAPTLM 950
The following BLAST results are available for this feature:
BLAST of Rho GTPase-activating protein 12 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CHN13.937e-926.67chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943][more]
CHN16.494e-925.24chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943][more]
CHN11.710e-825.24chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943][more]
CHN12.356e-825.24chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943][more]
ARHGAP219.152e-826.67Rho GTPase activating protein 21 [Source:HGNC Symb... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
pac-11.042e-928.79GTPase-activating protein pac-1 [Source:UniProtKB... [more]
pac-11.171e-928.79GTPase-activating protein pac-1 [Source:UniProtKB... [more]
pac-11.210e-928.79GTPase-activating protein pac-1 [Source:UniProtKB... [more]
pac-11.329e-928.79GTPase-activating protein pac-1 [Source:UniProtKB... [more]
pac-11.406e-928.79GTPase-activating protein pac-1 [Source:UniProtKB... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RhoGAPp1906.407e-1225.30gene:FBgn0026375 transcript:FBtr0333659[more]
RhoGAPp1906.794e-1225.30gene:FBgn0026375 transcript:FBtr0074481[more]
RhoGAPp1906.794e-1225.30gene:FBgn0026375 transcript:FBtr0074482[more]
RhoGAPp1906.794e-1225.30gene:FBgn0026375 transcript:FBtr0074483[more]
RhoGAPp1906.970e-1225.30gene:FBgn0026375 transcript:FBtr0333661[more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
chn25.152e-1128.85chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5][more]
chn25.675e-1128.85chimerin 2 [Source:ZFIN;Acc:ZDB-GENE-091020-5][more]
arhgap12b2.578e-928.37Rho GTPase activating protein 12b [Source:ZFIN;Acc... [more]
arhgap12b2.918e-928.37Rho GTPase activating protein 12b [Source:ZFIN;Acc... [more]
arhgap12b2.918e-928.37Rho GTPase activating protein 12b [Source:ZFIN;Acc... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ARHGAP232.155e-1226.75Rho GTPase activating protein 23 [Source:NCBI gene... [more]
ARHGAP232.408e-1226.75Rho GTPase activating protein 23 [Source:NCBI gene... [more]
ARHGAP232.485e-1226.75Rho GTPase activating protein 23 [Source:NCBI gene... [more]
ARHGAP232.967e-1226.75Rho GTPase activating protein 23 [Source:NCBI gene... [more]
ARHGAP233.256e-1226.75Rho GTPase activating protein 23 [Source:NCBI gene... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Arhgap236.748e-1225.21Rho GTPase activating protein 23 [Source:MGI Symbo... [more]
Arhgap231.240e-1124.29Rho GTPase activating protein 23 [Source:MGI Symbo... [more]
Arhgap51.257e-1027.14Rho GTPase activating protein 5 [Source:MGI Symbol... [more]
Chn16.412e-1025.71chimerin 1 [Source:MGI Symbol;Acc:MGI:1915674][more]
Chn16.412e-1025.71chimerin 1 [Source:MGI Symbol;Acc:MGI:1915674][more]
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BLAST of Rho GTPase-activating protein 12 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VX32|RG190_DROME6.810e-1125.30Rho GTPase-activating protein 190 OS=Drosophila me... [more]
sp|P97393|RHG05_MOUSE1.248e-827.14Rho GTPase-activating protein 5 OS=Mus musculus OX... [more]
sp|P34288|PAC1_CAEEL1.788e-828.79GTPase-activating protein pac-1 OS=Caenorhabditis ... [more]
sp|A4IF90|RHG15_BOVIN3.729e-828.23Rho GTPase-activating protein 15 OS=Bos taurus OX=... [more]
sp|Q6DFV3|RHG21_MOUSE1.201e-727.27Rho GTPase-activating protein 21 OS=Mus musculus O... [more]
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BLAST of Rho GTPase-activating protein 12 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4W3K4R52.784e-1030.30Rho-GAP domain-containing protein OS=Callorhinchus... [more]
A0A4W3KGJ07.178e-1029.87Uncharacterized protein OS=Callorhinchus milii OX=... [more]
A0A401NJL68.073e-1029.17Uncharacterized protein (Fragment) OS=Scyliorhinus... [more]
A0A3B3C1Q08.510e-1027.56Rho GTPase activating protein 23b OS=Oryzias melas... [more]
A0A3B3C1K78.972e-1027.56Rho GTPase activating protein 23b OS=Oryzias melas... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
arhgap12b3.286e-1028.37Rho GTPase activating protein 12 [Source:NCBI gene... [more]
arhgap12b3.389e-1028.37Rho GTPase activating protein 12 [Source:NCBI gene... [more]
arhgap12b3.405e-1028.37Rho GTPase activating protein 12 [Source:NCBI gene... [more]
arhgap12b3.416e-1028.37Rho GTPase activating protein 12 [Source:NCBI gene... [more]
arhgap12b3.459e-1028.37Rho GTPase activating protein 12 [Source:NCBI gene... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
arhgap53.884e-1230.21Rho GTPase activating protein 5 [Source:ZFIN;Acc:Z... [more]
ARHGAP158.183e-826.27Rho GTPase activating protein 15 [Source:HGNC Symb... [more]
arhgap21b4.991e-625.77Rho GTPase activating protein 21b [Source:ZFIN;Acc... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
BEM22.247e-626.86Rho GTPase activating protein (RhoGAP); involved i... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO314061.963e-724.89Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO490536.063e-729.15Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO449814.836e-627.10Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO382425.054e-628.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000035543.12.925e-1327.00rho GTPase-activating protein 23 [Source:NCBI gene... [more]
ENSORLT00000032335.13.607e-1327.00rho GTPase-activating protein 23 [Source:NCBI gene... [more]
ENSORLT00000045586.14.006e-1327.00rho GTPase-activating protein 23 [Source:NCBI gene... [more]
ENSORLT00000036475.14.392e-1327.00rho GTPase-activating protein 23 [Source:NCBI gene... [more]
arhgap21b2.945e-928.87rho GTPase-activating protein 21 [Source:NCBI gene... [more]
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BLAST of Rho GTPase-activating protein 12 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000012042.10.000e+098.91SMESG000012042.1[more]
SMESG000066536.18.217e-1625.00SMESG000066536.1[more]
SMESG000066536.18.457e-1625.00SMESG000066536.1[more]
SMESG000066536.18.796e-1625.00SMESG000066536.1[more]
SMESG000066536.18.895e-1625.00SMESG000066536.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30022973 ID=SMED30022973|Name=Rho GTPase-activating protein 12|organism=Schmidtea mediterranea sexual|type=transcript|length=4024bp
TCTATATAAATCTTATATGCAATATAATCAGAGATGAAGAGCTATTTTTA
GATTGATAAATATATCTTTTTACAATAGAATGGCTGAATTAAAAGTCTCC
CTCAATAATATTAGTGGCAAAGGCTATGGAATTAAAGTCGAAAAATGTGA
TTCTCGAAAAGACGGTCTCGTTATTGTATCAATGGACGCCGACAGCCAAG
CAAGTGTCAAAGGTTTGAAAGTTGGTGATAAAATTATTCGAGTTAATAAC
AAAAGTACTGAAAGTTGTCGAAACAAATTGATATCAGAACTTCATGATTC
AAAATCTAATCATGTTCTTTTGACAATTAAAAGAAACCTGAAGGACTTGC
GACACCAATCCGATAAAAATTTGAGCTCTTCAGTCTGTTCATTAAATGCG
AGTTTTCAGTCTATGTTCCGAAATTCCAAATCATCAATTGATCTCAAGTG
TTCTTATCAGCCGCTTTCTAAAATACTTGATTCGAATTATGTAACAGAAA
ATCATATTAATGAATTTTTTCAAGATGAACCAAACGATACAGTCGATAAC
TCCTATTTAGGACCTCAGAGTAATGAGAAATCAAATATATATTTAGAAGA
TAGTGATTCCAATCCCGGATCCCGTAAACAATCGACCTGCGTACCTCCTA
GTCCTTCAAATGTTCAACTTACCAGAAAAAAGGCTTATAAAAAGTCCGTT
GATGAAACAGAAAATATTTATCAATCTCAACAGCCAAAAATCAACCGAAA
GAAAGCAACGAATACATTGAATAATTCTAAAGAGTCGGTTCCAGTCGTTA
CAGTGAAAAGAAGAACTAATCAGGTAGTTGATAACAACAGTTTCGTCTAT
AGAAACTATTCAACCAACCGAAGCCTGAAACCCATTTGTTCCTCTCCATT
ATCGAAACCACTCAGCATTATTCCCAGCAGTTTCTCAAATTCCAGTTTGG
CGACTCCATCGGAGATTCCCATCAGCATCCAGCCGCTTTATAACACATAT
GAATCAGTGGATGGAAGCATGCATTCGAGGCTGAAAACGAATCTGATCAA
AGAAACGACATCCTTAAAAGAAATCAACTCATTGCCTACTTCAATTGAAT
GCGAAATGAAAATAATATCTTTCATTGATAAAAAGATTGCGAAACCAACA
TGGAAAATCTATTGGATGGAGATAGATTTTACCGGTGTTCACTTTCAGTG
TTCTGAATTATCACAAACTCAAGTAAGCTCCAATAGTACAGCATTGAACC
CATCAATTGTCAATCCTGAATTAATTATGAATGTTTGGGAAGTAAACAAC
AACATGACAAAATTTTATTTACCCATATTCCAATCGCCATACGATGAGCA
AATAATCCGATCCACTACTCTTGACGAGATTAAAATTAGTTTTCCACAAA
AAGTCGAATTTTCCATCAAACTTACCGAGGAGAATACTATTAAATTGTGC
CAGATGTTGAAAGTGCCAGAAATAAAAAACCCACCAATTAAACACAAGAA
GTCAGTTGTTTCTGTGGACAATCCACGCCCAGAACCGAGAAAGTTTAAGC
AAAGTCCCAAACCAATTACTGAAAAATTGATTTTGTCTTCCCTTCCTCAA
TCATCGAAAGTTGAGGGTGTTCCATTGTTTGTCGTTCTTTGTGCGTCGTT
GATTGAAGAGTTTGGGCTAGGAGACGTAGGCATTTATCGGAAAAGTGGAA
ATCTACCAGATAAACGAACACTGGAAGACGTTATAATGAATGAAAATCCA
GACAAATGGTCCTCGCATGATGAGTGGTTCAATGTACATACTGTTGCGAG
TTTATTCAAGAGCACTTTACGCAAGTACACTCTGTTAGATAAAGACATGG
CAATTAAATTGTCTATTATCAAGCTGGATGTGGATGAATCTACGAAGACC
GATGTCGACAAGAAGTTGCAAGATATTATGGATATGATATATCACCTAAA
TTTCAATTTCAAGTCAGCCGTTTCTGCCGAAGAAATCAAATGCAGATTTG
ACACTTTTAAATTTATTATAAAACATCTTTATCGTATGCAGCTGTGTCAA
GAAACTACAAAAATGAATGCAGAAAATCTGGCATTGTGCTTTGTGAATAA
TCTTATTGGAGATATTCCTGTGGATGATGTTATTCAGATTAAAGAAAGCA
GGGCAATCGTTGCTCAAGAAAATTTAACAAAGATGGTTTGTTTCTGGATT
ACATATGCTGAAGTTATGTGTGAATTATTGGAAGAACAAAAGGAAGAAGA
GTTGCCAGGAATGATAAAAGATTTCCTAAACCAGAAAAATTTCAACAATA
ATTTGTGTCAAATGCCCAACAATAATGAATATAAAACTGAAATCGATCGG
CAAAAGCTGATCAGAGAGCGCATTGAATATCATACCGAAAATGTGAATGC
TTCCAACTTGAATAGCAGCCCCAGAACTCCGGAAAGTTATTTCAGCCGAA
CTAAAAACAGTAGATTGTATCAAAGTGTAAAACAGCCACGATCGGTTAAA
AGTCGTCGACGGAACAATAGCGGTTCTTCAATGGATTTATTGAAATCTAC
GGAACTTACTAAACCCATCGATGGAACCGTAACCAACTTCAAAGATGACA
TGAAAAATCAAACAGGCAGTCCGATGTCTCAACGATTATTTACTGGTGTA
GGAGACCTTCGACTGAATAAAAATTTGAAAAAGGCTAAAGAACAACAATT
TGGATTCGTACCAGGGGTCAAAATGACAACTCTCTATTTTTCAGGCGATC
ATAAAGACGTACCCTTAGTAATTACAGCTTGTGTTGATATCATTGAAAAT
TTCGGTCTCAGAGTTGATGGTATCTACAGGGTTAGTGGAAGAAATTACGA
TATTTCTCAACTTGATCAATTAATAATGAAAAATGACACAGATAAATGGA
CTGAAGAGAGTAGTATTAAAATCTGGGCAACTTTGCACAGTACTGCTTGT
TTAATGAAAAAAATGCTAAAGAAATTCTGTTTGATACCGAAAGACACATG
GATGCACATGACGTCCCAGTTCTCAGAGAAGTTGGAGCCAGAAGATGTTA
AAAACGTACTGAAAGCTGCAGCTTATCATTTGAGGCTCGAACAAATCAAA
CCCAGCATGTATTGCAGTCAGGGAAAAATCAACTGTGACGAGAGTAGTTT
TATTAAATATCTTGAAAATCGTGTTCGAAGTGGAACGTTGAGATATGTGC
TAGAACATTTGAAGCACGTTTCATTACATGAATCACAAAATAGGATGCTC
ACCAATTCACTTGCTGTGTGTTTCGTACCGGTTCTGATGGAAGAGGACTA
TTCCAGTAATATGGTTGTGATTAATACTAAATGCATACAAATTGTTCAGT
TGCTCATTGATCATTGCGACTGGATATTCAAATGGGATTTCAAGCCGGCA
GAAGACATTTACGGTCAAATGATGTCAGATGATCTGGAAAAACATTTAAA
AGAATACCGACCCATTCCATGCCAGTGTGACAAAGCTAAAGACAGCAATT
ATGTCGCAAATCACAATCACATCAAAGAGTTGCTTGTCAAAATTATTCAA
TGCAGCTACCAATTTGAGGAACATGAAAAAAACAATATTATTACTTATTT
TGAACAGAAAAATTTTGAAAATATTGCAAAATTAGAAAATATTTGATATT
TTCCAATGAATGTTCTTATTTACCTGTCACACAGAAGTATTATTTTTTTA
GTGCAAAATACTCAATGTCTTTACTGCTCCAAGTGTCGATTTGACGCAAC
AATTCTAGAGTATAATTATTTTGTCTAATTCATTTTTCACTTGCCATGGT
TCTTGAGATGCGAATTGTAATGAATACGAGAAAGCTTTAATAAACAGTAT
TTCGTTACCGTTTCTATTTGTGATTATTCCCGATGAAGCTCTTGGACTGT
ATCTATTGTTAGAAATAAATATTTAAACTCGTTTTTATATTCATAAACTT
TATTTATTATCGCTTTTAATTTATTTTTTTGACTTTGCTTTGTTTTATTA
TTATCATTCTATCAATATATGCAC
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protein sequence of SMED30022973-orf-1

>SMED30022973-orf-1 ID=SMED30022973-orf-1|Name=SMED30022973-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1189bp
MAELKVSLNNISGKGYGIKVEKCDSRKDGLVIVSMDADSQASVKGLKVGD
KIIRVNNKSTESCRNKLISELHDSKSNHVLLTIKRNLKDLRHQSDKNLSS
SVCSLNASFQSMFRNSKSSIDLKCSYQPLSKILDSNYVTENHINEFFQDE
PNDTVDNSYLGPQSNEKSNIYLEDSDSNPGSRKQSTCVPPSPSNVQLTRK
KAYKKSVDETENIYQSQQPKINRKKATNTLNNSKESVPVVTVKRRTNQVV
DNNSFVYRNYSTNRSLKPICSSPLSKPLSIIPSSFSNSSLATPSEIPISI
QPLYNTYESVDGSMHSRLKTNLIKETTSLKEINSLPTSIECEMKIISFID
KKIAKPTWKIYWMEIDFTGVHFQCSELSQTQVSSNSTALNPSIVNPELIM
NVWEVNNNMTKFYLPIFQSPYDEQIIRSTTLDEIKISFPQKVEFSIKLTE
ENTIKLCQMLKVPEIKNPPIKHKKSVVSVDNPRPEPRKFKQSPKPITEKL
ILSSLPQSSKVEGVPLFVVLCASLIEEFGLGDVGIYRKSGNLPDKRTLED
VIMNENPDKWSSHDEWFNVHTVASLFKSTLRKYTLLDKDMAIKLSIIKLD
VDESTKTDVDKKLQDIMDMIYHLNFNFKSAVSAEEIKCRFDTFKFIIKHL
YRMQLCQETTKMNAENLALCFVNNLIGDIPVDDVIQIKESRAIVAQENLT
KMVCFWITYAEVMCELLEEQKEEELPGMIKDFLNQKNFNNNLCQMPNNNE
YKTEIDRQKLIRERIEYHTENVNASNLNSSPRTPESYFSRTKNSRLYQSV
KQPRSVKSRRRNNSGSSMDLLKSTELTKPIDGTVTNFKDDMKNQTGSPMS
QRLFTGVGDLRLNKNLKKAKEQQFGFVPGVKMTTLYFSGDHKDVPLVITA
CVDIIENFGLRVDGIYRVSGRNYDISQLDQLIMKNDTDKWTEESSIKIWA
TLHSTACLMKKMLKKFCLIPKDTWMHMTSQFSEKLEPEDVKNVLKAAAYH
LRLEQIKPSMYCSQGKINCDESSFIKYLENRVRSGTLRYVLEHLKHVSLH
ESQNRMLTNSLAVCFVPVLMEEDYSSNMVVINTKCIQIVQLLIDHCDWIF
KWDFKPAEDIYGQMMSDDLEKHLKEYRPIPCQCDKAKDSNYVANHNHIKE
LLVKIIQCSYQFEEHEKNNIITYFEQKNFENIAKLENI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005096GTPase activator activity
GO:0005515protein binding
Vocabulary: biological process
TermDefinition
GO:0043547positive regulation of GTPase activity
GO:0007165signal transduction
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR036034PDZ_sf
IPR008936Rho_GTPase_activation_prot
IPR000198RhoGAP_dom
IPR001478PDZ
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 14..87
e-value: 1.3E-9
score: 48.0
IPR001478PDZ domainPFAMPF00595PDZcoord: 8..83
e-value: 3.5E-8
score: 33.7
IPR001478PDZ domainPROSITEPS50106PDZcoord: 5..87
score: 11.059
IPR000198Rho GTPase-activating protein domainSMARTSM00324RhoGAP_3coord: 892..1097
e-value: 2.5E-8
score: 43.7
coord: 512..711
e-value: 1.7E-16
score: 70.8
IPR000198Rho GTPase-activating protein domainPFAMPF00620RhoGAPcoord: 895..1074
e-value: 3.4E-18
score: 65.9
coord: 515..677
e-value: 6.5E-18
score: 65.0
IPR000198Rho GTPase-activating protein domainPROSITEPS50238RHOGAPcoord: 880..1100
score: 21.668
IPR000198Rho GTPase-activating protein domainPROSITEPS50238RHOGAPcoord: 500..714
score: 18.304
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 4..104
e-value: 2.3E-11
score: 45.6
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 13..88
IPR008936Rho GTPase activation proteinGENE3DG3DSA:1.10.555.10coord: 443..722
e-value: 1.7E-24
score: 88.3
coord: 831..1110
e-value: 4.1E-30
score: 106.7
IPR008936Rho GTPase activation proteinSUPERFAMILYSSF48350GTPase activation domain, GAPcoord: 509..687
IPR008936Rho GTPase activation proteinSUPERFAMILYSSF48350GTPase activation domain, GAPcoord: 890..1101
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 772..825
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 209..223
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 174..223
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 174..200
NoneNo IPR availablePANTHERPTHR23176:SF0RHO GTPASE ACTIVATING PROTEIN 23coord: 1036..1109
NoneNo IPR availablePANTHERPTHR23176RHO/RAC/CDC GTPASE-ACTIVATING PROTEINcoord: 1036..1109
NoneNo IPR availablePANTHERPTHR23176:SF0RHO GTPASE ACTIVATING PROTEIN 23coord: 502..582
NoneNo IPR availablePANTHERPTHR23176:SF0RHO GTPASE ACTIVATING PROTEIN 23coord: 639..676
NoneNo IPR availablePANTHERPTHR23176:SF0RHO GTPASE ACTIVATING PROTEIN 23coord: 890..960
NoneNo IPR availablePANTHERPTHR23176RHO/RAC/CDC GTPASE-ACTIVATING PROTEINcoord: 639..676
coord: 890..960
NoneNo IPR availablePANTHERPTHR23176RHO/RAC/CDC GTPASE-ACTIVATING PROTEINcoord: 502..582
NoneNo IPR availableCDDcd00159RhoGAPcoord: 895..1095
e-value: 4.6767E-20
score: 86.5868
NoneNo IPR availableCDDcd00159RhoGAPcoord: 515..695
e-value: 5.95132E-20
score: 86.2016
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 6..84
e-value: 4.14805E-8
score: 49.4875