Reactive oxygen species modulator 1 family protein

Overview
NameReactive oxygen species modulator 1 family protein
Smed IDSMED30022855
Length (bp)467
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Reactive oxygen species modulator 1 family protein (SMED30022855) t-SNE clustered cells

Violin plots show distribution of expression levels for Reactive oxygen species modulator 1 family protein (SMED30022855) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Reactive oxygen species modulator 1 family protein (SMED30022855) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Reactive oxygen species modulator 1 family protein (SMED30022855) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30022855

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30022855 dd_Smed_v4_691_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gamma neoblastSMED30022855 dd_Smed_v6_691_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30022855 dd_Smed_v6_691_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Human
Match: ROMO1 (reactive oxygen species modulator 1 [Source:HGNC Symbol;Acc:HGNC:16185])

HSP 1 Score: 65.855 bits (159), Expect = 1.572e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Human
Match: ROMO1 (reactive oxygen species modulator 1 [Source:HGNC Symbol;Acc:HGNC:16185])

HSP 1 Score: 65.855 bits (159), Expect = 1.572e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Human
Match: ROMO1 (reactive oxygen species modulator 1 [Source:HGNC Symbol;Acc:HGNC:16185])

HSP 1 Score: 65.855 bits (159), Expect = 1.572e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Human
Match: ROMO1 (reactive oxygen species modulator 1 [Source:HGNC Symbol;Acc:HGNC:16185])

HSP 1 Score: 65.855 bits (159), Expect = 1.572e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Celegans
Match: romo-1 ((Reactive Oxygen species MOdulator) homolog [Source:UniProtKB/TrEMBL;Acc:Q93511])

HSP 1 Score: 55.4546 bits (132), Expect = 7.017e-11
Identity = 35/82 (42.68%), Postives = 51/82 (62.20%), Query Frame = 2 
Query:  101 MPVVS--STRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV S  +  P   + SC  +++MG  MG  +G  +G++ GGF  FR G+RG +L    GK++ Q GG+FGVFM +  G+RC
Sbjct:    1 MPVPSGYAAHPQGSQPSCFTKIRMGLMMGAMIGGATGILLGGFMGFRAGMRGKDLLLQTGKTVAQSGGSFGVFMGVAQGLRC 82
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Fly
Match: CG6878 (gene:FBgn0036488 transcript:FBtr0075643)

HSP 1 Score: 76.6406 bits (187), Expect = 5.894e-19
Identity = 51/80 (63.75%), Postives = 61/80 (76.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MP+ +S+    G  +C D+MK GF +GFCVGM SG +FGGF+  R+GLRG EL   VGK+MVQGGGTFG FMAIGTGIRC
Sbjct:    1 MPLPTSSFSQQGP-TCFDKMKTGFIIGFCVGMASGAVFGGFSALRYGLRGRELINNVGKTMVQGGGTFGTFMAIGTGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Zebrafish
Match: romo1 (reactive oxygen species modulator 1 [Source:NCBI gene;Acc:393770])

HSP 1 Score: 70.0922 bits (170), Expect = 3.141e-16
Identity = 47/80 (58.75%), Postives = 56/80 (70.00%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV   +     + SC DR+KMGF MGF VGM +G +FG F+C R G+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVSVGSYGQQAQPSCFDRVKMGFMMGFAVGMAAGAMFGTFSCLRIGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Xenopus
Match: slc10a4 (solute carrier family 10 member 4 [Source:Xenbase;Acc:XB-GENE-940175])

HSP 1 Score: 68.9366 bits (167), Expect = 1.162e-15
Identity = 49/80 (61.25%), Postives = 57/80 (71.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MGF VGM +G +FG F+C RFG+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFMMGFAVGMAAGALFGTFSCLRFGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Mouse
Match: Romo1 (reactive oxygen species modulator 1 [Source:MGI Symbol;Acc:MGI:1914317])

HSP 1 Score: 65.855 bits (159), Expect = 1.079e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Mouse
Match: Romo1 (reactive oxygen species modulator 1 [Source:MGI Symbol;Acc:MGI:1914317])

HSP 1 Score: 65.855 bits (159), Expect = 1.079e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Mouse
Match: Romo1 (reactive oxygen species modulator 1 [Source:MGI Symbol;Acc:MGI:1914317])

HSP 1 Score: 65.855 bits (159), Expect = 1.079e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Mouse
Match: Romo1 (reactive oxygen species modulator 1 [Source:MGI Symbol;Acc:MGI:1914317])

HSP 1 Score: 65.855 bits (159), Expect = 1.079e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Match: sp|Q6NYD1|ROMO1_DANRE (Reactive oxygen species modulator 1 OS=Danio rerio OX=7955 GN=romo1 PE=3 SV=1)

HSP 1 Score: 70.0922 bits (170), Expect = 2.371e-15
Identity = 47/80 (58.75%), Postives = 56/80 (70.00%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV   +     + SC DR+KMGF MGF VGM +G +FG F+C R G+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVSVGSYGQQAQPSCFDRVKMGFMMGFAVGMAAGAMFGTFSCLRIGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Match: sp|A4QNF3|ROMO1_XENTR (Reactive oxygen species modulator 1 OS=Xenopus tropicalis OX=8364 GN=romo1 PE=3 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 6.158e-15
Identity = 49/80 (61.25%), Postives = 57/80 (71.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MGF VGM +G +FG F+C RFG+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFMMGFAVGMAAGALFGTFSCLRFGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Match: sp|Q4V7T9|ROMO1_XENLA (Reactive oxygen species modulator 1 OS=Xenopus laevis OX=8355 GN=romo1 PE=3 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 1.712e-14
Identity = 48/80 (60.00%), Postives = 57/80 (71.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + +C DR+KMGF MGF VGM +G +FG F+C RFG+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPNCFDRVKMGFMMGFAVGMAAGALFGTFSCLRFGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Match: sp|P60603|ROMO1_MOUSE (Reactive oxygen species modulator 1 OS=Mus musculus OX=10090 GN=Romo1 PE=2 SV=1)

HSP 1 Score: 65.855 bits (159), Expect = 7.549e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Match: sp|P60602|ROMO1_HUMAN (Reactive oxygen species modulator 1 OS=Homo sapiens OX=9606 GN=ROMO1 PE=1 SV=1)

HSP 1 Score: 65.855 bits (159), Expect = 7.549e-14
Identity = 46/80 (57.50%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV       S + SC DR+KMGF MG  VGM +G +FG F+C R G+RG EL   +GK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPYGQS-QPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Match: A0A2C9K734 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106053786 PE=4 SV=1)

HSP 1 Score: 86.2705 bits (212), Expect = 2.998e-19
Identity = 56/80 (70.00%), Postives = 63/80 (78.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV SS     G  SC DR+K+GF MGFCVGM SG +FGGF+  R+GLRG ELF TVGK+M+QGGGTFG FMAIGTGIRC
Sbjct:    1 MPVPSSVYGHQGAPSCFDRIKVGFMMGFCVGMASGALFGGFSALRYGLRGKELFSTVGKTMIQGGGTFGTFMAIGTGIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Match: A0A3S1BRC5 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_019190 PE=4 SV=1)

HSP 1 Score: 84.7297 bits (208), Expect = 1.229e-18
Identity = 55/80 (68.75%), Postives = 63/80 (78.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV SS     G  SC DR+K+GF MGFCVGM SG +FGGF+  R+GLRG ELF TVGK+M+QGGGTFG FM+IGTGIRC
Sbjct:    1 MPVPSSAYGHQGAPSCFDRIKVGFMMGFCVGMASGALFGGFSALRYGLRGRELFSTVGKTMIQGGGTFGTFMSIGTGIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Match: A0A183ST19 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS7367 PE=4 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.775e-17
Identity = 54/80 (67.50%), Postives = 62/80 (77.50%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV   +     + SC  RMKMGF MGFCVG+ +G IFGGF+C RFGLRG EL +TVGKSM+QGGGTFG+FMAIGT IRC
Sbjct:   44 MPVAPGSYGQMSQPSCFSRMKMGFMMGFCVGVATGAIFGGFSCLRFGLRGRELVQTVGKSMIQGGGTFGMFMAIGTAIRC 123
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Match: A0A504Y9L6 (Reactive oxygen species modulator OS=Fasciola gigantica OX=46835 GN=FGIG_11467 PE=4 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 2.612e-17
Identity = 52/80 (65.00%), Postives = 61/80 (76.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV  +      + SC DR+K GF MGFCVG+ SG IFGGF+C RFGLRG EL +TVGK M+QGGGTFG+FMA+GT IRC
Sbjct:    1 MPVAPNAFGGISQPSCFDRIKYGFMMGFCVGVASGAIFGGFSCLRFGLRGRELLQTVGKGMIQGGGTFGMFMAVGTAIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Match: A0A2H1CEF2 (Reactive oxygen species modulator 1 family protein OS=Fasciola hepatica OX=6192 GN=D915_06999 PE=4 SV=1)

HSP 1 Score: 81.2629 bits (199), Expect = 2.612e-17
Identity = 52/80 (65.00%), Postives = 61/80 (76.25%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV  +      + SC DR+K GF MGFCVG+ SG IFGGF+C RFGLRG EL +TVGK M+QGGGTFG+FMA+GT IRC
Sbjct:    1 MPVAPNAFGGISQPSCFDRIKYGFMMGFCVGVASGAIFGGFSCLRFGLRGRELLQTVGKGMIQGGGTFGMFMAVGTAIRC 80
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Cavefish
Match: romo1 (reactive oxygen species modulator 1 [Source:NCBI gene;Acc:103027874])

HSP 1 Score: 65.855 bits (159), Expect = 1.017e-14
Identity = 47/80 (58.75%), Postives = 55/80 (68.75%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPV         + SC DR+KMGF MGF VGM +G +FG F+C R G+RG EL   VGK+M+Q GGTFG FMAIG GIRC
Sbjct:    1 MPVAVGPY-GQAQPSCFDRVKMGFMMGFAVGMAAGAMFGTFSCLRIGMRGRELMGGVGKTMMQSGGTFGTFMAIGMGIRC 79
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Nematostella
Match: EDO47695 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLI1])

HSP 1 Score: 67.0106 bits (162), Expect = 1.043e-15
Identity = 41/70 (58.57%), Postives = 54/70 (77.14%), Query Frame = 2 
Query:  131 SGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            + + SC DR+K+GF +GF VGM S  +FG ++  R+GLRG EL  +VGK M+QGGGTFGVFM++GT IRC
Sbjct:    4 APQPSCFDRVKVGFMIGFAVGMSSAGLFGTYSALRYGLRGRELMSSVGKLMLQGGGTFGVFMSVGTAIRC 73
[Close]
BLAST of Reactive oxygen species modulator 1 family protein vs. Planmine SMEST
Match: SMESG000039761.1 (SMESG000039761.1)

HSP 1 Score: 120.168 bits (300), Expect = 3.297e-36
Identity = 80/80 (100.00%), Postives = 80/80 (100.00%), Query Frame = 2 
Query:  101 MPVVSSTRPSSGKVSCLDRMKXXXXXXXXXXXXXXXIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 340
            MPVVSSTRPSSGKVSCLDRMKMGFGMGFCVGMVSGVIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC
Sbjct:    1 MPVVSSTRPSSGKVSCLDRMKMGFGMGFCVGMVSGVIFGGFNCFRFGLRGSELFKTVGKSMVQGGGTFGVFMAIGTGIRC 80
The following BLAST results are available for this feature:
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ROMO11.572e-1457.50reactive oxygen species modulator 1 [Source:HGNC S... [more]
ROMO11.572e-1457.50reactive oxygen species modulator 1 [Source:HGNC S... [more]
ROMO11.572e-1457.50reactive oxygen species modulator 1 [Source:HGNC S... [more]
ROMO11.572e-1457.50reactive oxygen species modulator 1 [Source:HGNC S... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
romo-17.017e-1142.68(Reactive Oxygen species MOdulator) homolog [Sour... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG68785.894e-1963.75gene:FBgn0036488 transcript:FBtr0075643[more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
romo13.141e-1658.75reactive oxygen species modulator 1 [Source:NCBI g... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
slc10a41.162e-1561.25solute carrier family 10 member 4 [Source:Xenbase;... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Romo11.079e-1457.50reactive oxygen species modulator 1 [Source:MGI Sy... [more]
Romo11.079e-1457.50reactive oxygen species modulator 1 [Source:MGI Sy... [more]
Romo11.079e-1457.50reactive oxygen species modulator 1 [Source:MGI Sy... [more]
Romo11.079e-1457.50reactive oxygen species modulator 1 [Source:MGI Sy... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6NYD1|ROMO1_DANRE2.371e-1558.75Reactive oxygen species modulator 1 OS=Danio rerio... [more]
sp|A4QNF3|ROMO1_XENTR6.158e-1561.25Reactive oxygen species modulator 1 OS=Xenopus tro... [more]
sp|Q4V7T9|ROMO1_XENLA1.712e-1460.00Reactive oxygen species modulator 1 OS=Xenopus lae... [more]
sp|P60603|ROMO1_MOUSE7.549e-1457.50Reactive oxygen species modulator 1 OS=Mus musculu... [more]
sp|P60602|ROMO1_HUMAN7.549e-1457.50Reactive oxygen species modulator 1 OS=Homo sapien... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2C9K7342.998e-1970.00Uncharacterized protein OS=Biomphalaria glabrata O... [more]
A0A3S1BRC51.229e-1868.75Uncharacterized protein OS=Elysia chlorotica OX=18... [more]
A0A183ST191.775e-1767.50Uncharacterized protein OS=Schistocephalus solidus... [more]
A0A504Y9L62.612e-1765.00Reactive oxygen species modulator OS=Fasciola giga... [more]
A0A2H1CEF22.612e-1765.00Reactive oxygen species modulator 1 family protein... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
romo11.017e-1458.75reactive oxygen species modulator 1 [Source:NCBI g... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO476951.043e-1558.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Reactive oxygen species modulator 1 family protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000039761.13.297e-36100.00SMESG000039761.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30022855 ID=SMED30022855|Name=Reactive oxygen species modulator 1 family protein|organism=Schmidtea mediterranea sexual|type=transcript|length=467bp
GGAATTAATGATACAATTCTATTTGTTTAAATAATGAACTTTTTTTTCAC
ATTTAACTTAAAAGTTACATAAATTTAATATAATTATTTAATATTGTATT
ATGCCAGTTGTGTCATCTACTAGACCTAGTTCAGGTAAAGTATCGTGTTT
GGATCGCATGAAAATGGGTTTTGGTATGGGATTCTGTGTTGGTATGGTTT
CTGGTGTTATTTTTGGAGGATTTAATTGCTTCAGGTTTGGCTTACGTGGT
TCAGAGTTATTTAAAACTGTTGGTAAATCTATGGTCCAAGGAGGTGGTAC
TTTTGGCGTTTTTATGGCTATAGGAACCGGAATTCGTTGTTAATTTGTAA
AATTTATTCAGTCGACAAAAACCAAATAGTTTATATTTAATAGTTCTTAA
TAAATATTTTGCAACATTAAAAAAAAAAAAAAAAANAAAAAAAAAAAAAA
NAAAAAAAAAAACTAAA
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000039gamma neoblast
PLANA:0000429neoblast
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR018450Romo1/Mgr2
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR018450Romo1/Mgr2SMARTSM01378Romo1_2coord: 14..80
e-value: 1.7E-28
score: 110.7
IPR018450Romo1/Mgr2PFAMPF10247Romo1coord: 15..80
e-value: 7.9E-25
score: 87.0
IPR018450Romo1/Mgr2PANTHERPTHR28525FAMILY NOT NAMEDcoord: 5..80
NoneNo IPR availablePANTHERPTHR28525:SF1REACTIVE OXYGEN SPECIES MODULATOR 1coord: 5..80
NoneNo IPR availableTMHMMTMhelixcoord: 56..78
NoneNo IPR availableTMHMMTMhelixcoord: 22..44