Protein kinase domain-containing protein

Overview


Name	Protein kinase domain-containing protein
Smed ID	SMED30022730
Length (bp)	1359

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein kinase domain-containing protein (SMED30022730) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30022730) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30022730) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30022730) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022730

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
nervous system	SMED30022730	SMESG000012497.1 SMESG000012496.1	dd_Smed_v4_11598_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30022730	SMESG000012497.1 SMESG000012496.1	dd_Smed_v4_11598_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 400.208 bits (1027), Expect = 1.739e-136
Identity = 179/320 (55.94%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 399.053 bits (1024), Expect = 2.952e-135
Identity = 179/320 (55.94%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 391.734 bits (1005), Expect = 1.848e-133
Identity = 178/321 (55.45%), Postives = 243/321 (75.70%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ++YTD  +IGNG+FGVVY A L +++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL++EY+P+TVY + R + + +  IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RL+ LE+  +++F+ELR    +LPN    P L +FS  EL+I+PSLN
Sbjct:   35 VAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLN 355

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 392.889 bits (1008), Expect = 1.046e-132
Identity = 178/321 (55.45%), Postives = 243/321 (75.70%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ++YTD  +IGNG+FGVVY A L +++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL++EY+P+TVY + R + + +  IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RL+ LE+  +++F+ELR    +LPN    P L +FS  EL+I+PSLN
Sbjct:  117 VAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLN 437

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 392.889 bits (1008), Expect = 1.046e-132
Identity = 178/321 (55.45%), Postives = 243/321 (75.70%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ++YTD  +IGNG+FGVVY A L +++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL++EY+P+TVY + R + + +  IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RL+ LE+  +++F+ELR    +LPN    P L +FS  EL+I+PSLN
Sbjct:  117 VAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLN 437

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gsk-3 (Glycogen synthase kinase-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2Q9])

HSP 1 Score: 362.073 bits (928), Expect = 1.040e-122
Identity = 169/309 (54.69%), Postives = 226/309 (73.14%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSL 1032
            Q  ISY D+ +IGNG+FGVV+ A L  + E VAIK+V QDKR+KNRELQIM+ L HPN++ L Y+F  +GEK D+ YLNLI+EY+P+TVY + R Y + R  IP  YVK++ YQ+LR LAY+H   I HRDIKP NLL++ E+G+LKLCDFGSAK LV  +PNV+YICSR+YRAPELI G+ NYT +IDVWSAG V+AE+LLG+ +F G + +DQLVEIIK++G+P+  QI+ MN  Y EFK P++   P+ K+F      E I L++ ++EY+P  R T   +  + +F+ELR    RLP+G   P+L
Sbjct:   31 QVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTL 339

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: C44H4.6 (pep chromosome:WBcel235:X:14596476:14599158:-1 gene:WBGene00008095.1 transcript:C44H4.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C44H4.6)

HSP 1 Score: 263.462 bits (672), Expect = 3.842e-84
Identity = 125/308 (40.58%), Postives = 188/308 (61.04%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDF 1041
            I +T+  +IG G+FG VY A L ++ E +AIK++  D R+K+REL IM  + HPN+I LLYY++   E     LN +ME++P  +  + R++  N   +P+  +K++ +Q+LRG+ ++H   IVHRDIKP NLLV+   GILK+CDFGSAK L   +PN+ YICSR+YRAPELI GS NY  +ID WS G V+ E+L    +F   + +D L   IK  G+PS   + + N  Y       ++ +  +K    K+    + LL  L++  P  R+   E+L   YF++LR+  ++LP+G   P L D+
Sbjct:   35 IQFTNLQLIGTGSFGAVYKAVLRENDEPIAIKKIKVDDRFKSRELTIMHEMDHPNIIRLLYYYVMQQE---NCLNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRGIGFLHLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPNITYICSRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLADSAVDILALQIKAFGTPSKEDMAKWNYEYVHIPYDTITGVGIQKFIGRKLSLSTLELLNSLMKMDPKLRIKPYEALTLPYFDDLRDPHYKLPSGAPIPPLFDW 339

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pmk-1 (Mitogen-activated protein kinase pmk-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17446])

HSP 1 Score: 171.4 bits (433), Expect = 8.181e-49
Identity = 102/297 (34.34%), Postives = 165/297 (55.56%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIK---RVFQD---KRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDT----YLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNE---FKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYF 975
            Y + T IG G +G V  A    S  +VAIK   R FQ     R   REL++++ + H N+I LL  F  N   +D     +++++M      +  + R        +   +++   YQ+LRGL Y+H   I+HRD+KP+N+ VN E   LK+ DFG A+   S      Y+ +R+YRAPE++L   +YT  +DVWS GC++AE++ G+ LF G ++IDQL  I+ + G+P    +++++S         LPKM+   F++LF+ +  P+ I LL  +L   P +R T+ E++ + Y 
Sbjct:   35 YINLTPIGTGAYGTVCAAECTRSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCMCHENIIDLLDVFTPNENVNDIEDVYFVSMLMGADLSNILKIQR--------LNDDHIQFLVYQILRGLKYIHSADIIHRDLKPSNIAVN-EDCELKILDFGLARQTDSEM--TGYVATRWYRAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEEARNYIRNLPKMTRRDFKRLFA-QATPQAIDLLEKMLHLDPDRRPTAKEAMEHEYL 319

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: dyf-5 (Serine/threonine-protein kinase dyf-5 [Source:UniProtKB/Swiss-Prot;Acc:B3WFY8])

HSP 1 Score: 169.474 bits (428), Expect = 3.293e-47
Identity = 94/286 (32.87%), Postives = 169/286 (59.09%), Query Frame = 1

Query:  142 IGNGTFGVVYGATLCDSKEKVAIKRVFQ-----DKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIRE---MNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYF 975
            +G+GTFG V  A   D+ ++VAIKR+ +     ++    RE++ +K L HPN+I L         +++  L  + E++ + +Y+L++   +     P   ++   YQ+L+GLA+MH     HRD+KP N++ N  T ++K+ DFG A+ + S  P   Y+ +R+YRAPE++L S +Y   ID+W+ GC++AE+ + R LF G + +DQL +II I+G+P+ ++  E   + S  N F+  ++   P E++  + +  E + L+  ++ ++P +R  + +SL Y YF
Sbjct:   17 LGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLREVI-----RENDILYFVFEFMQENLYELMKDRDR---YFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCN-GTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMN-FRFQQVVATPMEQVV-NTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYF 291

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: dyf-5 (Serine/threonine-protein kinase dyf-5 [Source:UniProtKB/Swiss-Prot;Acc:B3WFY8])

HSP 1 Score: 169.859 bits (429), Expect = 3.892e-47
Identity = 94/286 (32.87%), Postives = 169/286 (59.09%), Query Frame = 1

Query:  142 IGNGTFGVVYGATLCDSKEKVAIKRVFQ-----DKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIRE---MNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYF 975
            +G+GTFG V  A   D+ ++VAIKR+ +     ++    RE++ +K L HPN+I L         +++  L  + E++ + +Y+L++   +     P   ++   YQ+L+GLA+MH     HRD+KP N++ N  T ++K+ DFG A+ + S  P   Y+ +R+YRAPE++L S +Y   ID+W+ GC++AE+ + R LF G + +DQL +II I+G+P+ ++  E   + S  N F+  ++   P E++  + +  E + L+  ++ ++P +R  + +SL Y YF
Sbjct:   17 LGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLREVI-----RENDILYFVFEFMQENLYELMKDRDR---YFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCN-GTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMN-FRFQQVVATPMEQVV-NTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYF 291

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070475)

HSP 1 Score: 388.652 bits (997), Expect = 3.692e-131
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELR-ESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVV+ A LCD+ E VAIK+V QD+R+KNRELQIM+ L+H N++ LLY+F  +GEK D+ +LNL++EYIP+TVY + R+Y + +  IP  +++++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ NYT  IDVWSAGCV+AE+LLG+ +F G + +DQLVE+IK++G+P+  QIREMN  Y EFK P++   P++K+F  +   E I+L++ LLEY+P  R+T L++  + +F+ELR E +  LPNG   P L +F+  EL+I+PSL
Sbjct:   34 VSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 354

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070469)

HSP 1 Score: 389.037 bits (998), Expect = 3.997e-131
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELR-ESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVV+ A LCD+ E VAIK+V QD+R+KNRELQIM+ L+H N++ LLY+F  +GEK D+ +LNL++EYIP+TVY + R+Y + +  IP  +++++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ NYT  IDVWSAGCV+AE+LLG+ +F G + +DQLVE+IK++G+P+  QIREMN  Y EFK P++   P++K+F  +   E I+L++ LLEY+P  R+T L++  + +F+ELR E +  LPNG   P L +F+  EL+I+PSL
Sbjct:   52 VSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070472)

HSP 1 Score: 389.037 bits (998), Expect = 3.997e-131
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELR-ESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVV+ A LCD+ E VAIK+V QD+R+KNRELQIM+ L+H N++ LLY+F  +GEK D+ +LNL++EYIP+TVY + R+Y + +  IP  +++++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ NYT  IDVWSAGCV+AE+LLG+ +F G + +DQLVE+IK++G+P+  QIREMN  Y EFK P++   P++K+F  +   E I+L++ LLEY+P  R+T L++  + +F+ELR E +  LPNG   P L +F+  EL+I+PSL
Sbjct:   52 VSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070473)

HSP 1 Score: 389.037 bits (998), Expect = 3.997e-131
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELR-ESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVV+ A LCD+ E VAIK+V QD+R+KNRELQIM+ L+H N++ LLY+F  +GEK D+ +LNL++EYIP+TVY + R+Y + +  IP  +++++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ NYT  IDVWSAGCV+AE+LLG+ +F G + +DQLVE+IK++G+P+  QIREMN  Y EFK P++   P++K+F  +   E I+L++ LLEY+P  R+T L++  + +F+ELR E +  LPNG   P L +F+  EL+I+PSL
Sbjct:   52 VSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070468)

HSP 1 Score: 389.037 bits (998), Expect = 3.997e-131
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELR-ESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVV+ A LCD+ E VAIK+V QD+R+KNRELQIM+ L+H N++ LLY+F  +GEK D+ +LNL++EYIP+TVY + R+Y + +  IP  +++++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ NYT  IDVWSAGCV+AE+LLG+ +F G + +DQLVE+IK++G+P+  QIREMN  Y EFK P++   P++K+F  +   E I+L++ LLEY+P  R+T L++  + +F+ELR E +  LPNG   P L +F+  EL+I+PSL
Sbjct:   52 VSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: gsk3ba (glycogen synthase kinase 3 beta, genome duplicate a [Source:ZFIN;Acc:ZDB-GENE-990714-4])

HSP 1 Score: 401.749 bits (1031), Expect = 3.001e-137
Identity = 180/320 (56.25%), Postives = 245/320 (76.56%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +G+K D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELRE + +LPNG + PSL +F+ +EL+  P+L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELREPNVKLPNGREKPSLFNFTTQELSSNPTL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: gsk3bb (glycogen synthase kinase 3 beta, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-090312-2])

HSP 1 Score: 400.208 bits (1027), Expect = 1.070e-136
Identity = 180/320 (56.25%), Postives = 243/320 (75.94%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +G+K D+ YLNL+M+Y+P+ VY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +T+F+ELRE + +LPNG + P L +F+ +EL+  PSL
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVMDYVPENVYRVARHYSKAKQNLPMVYVKLYMYQLFRSLAYIHSYGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHTFFDELREPNLKLPNGRERPVLFNFTTQELSNNPSL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: gsk3ab (glycogen synthase kinase 3 alpha b [Source:ZFIN;Acc:ZDB-GENE-990714-3])

HSP 1 Score: 400.593 bits (1028), Expect = 1.638e-136
Identity = 180/321 (56.07%), Postives = 247/321 (76.95%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L DS+E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++++P+TVY + R + +++T IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ LE+  + +F+ELR+ + RLPNG + P L +FS  EL+I+P LN
Sbjct:   81 VSYTDIKVIGNGSFGVVYQARLIDSQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKSKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAISLCSRLLEYTPVTRLSPLEACAHAFFDELRQPNARLPNGRELPQLFNFSPVELSIQPQLN 401

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: gsk3aa (glycogen synthase kinase 3 alpha a [Source:ZFIN;Acc:ZDB-GENE-060503-796])

HSP 1 Score: 396.356 bits (1017), Expect = 1.258e-134
Identity = 178/321 (55.45%), Postives = 244/321 (76.01%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R + + +T+IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ L++  + +F+ELR+   RLP+G + P L +F+  EL I+P LN
Sbjct:  108 VSYTDIKVIGNGSFGVVYQARLIDTHEWVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYCSGEKKDEVYLNLVLDYVPETVYRVARHFSKAKTIIPIFYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPPLFNFTTTELMIQPQLN 428

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: zgc:171775 (zgc:171775 [Source:ZFIN;Acc:ZDB-GENE-030131-4309])

HSP 1 Score: 175.252 bits (443), Expect = 3.892e-50
Identity = 106/300 (35.33%), Postives = 170/300 (56.67%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQ------DKRYKNRELQIMKMLQHPNVIALLYYFIHNG--EKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEF---KLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRE 990
            YT    +G+G +G V  A    +KEKVAIK++++        +   REL++++ +QH NVI LL  F  +   EK DT+  ++M ++   +  +++     R  + S  +    YQ+LRGL Y+H   I+HRD+KP NL V+ E   LK+ DFG A+   +      Y+ +R+YRAPE+I    +YT  +DVWSAGC++AEM+ G  LF G ++IDQL +I+ + G+P++  + +M S   +     LP      F+++FS  +DP  I LL  +L   P  RL++   L + Y +E  +
Sbjct:   25 YTSLKPVGSGAYGTVCFAVDQKTKEKVAIKKLYRPFQSLIHAKRAYRELRLLRHIQHDNVICLLNVFTPDSSLEKFDTFY-MVMPFVAQDLGHIMK-----RKQLTSNVITYLFYQILRGLKYIHSAGIIHRDLKPNNLAVD-ENCELKILDFGLARHTETEM--TGYVVTRWYRAPEVIFNWMHYTQTVDVWSAGCILAEMITGEVLFPGSDSIDQLKKILNLTGTPNSTLVLKMQSKDAQSYVRSLPVQKKKAFKEVFSG-MDPNAIDLLEGMLVLDPEVRLSAKNGLSHPYLSEFHD 314

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 400.208 bits (1027), Expect = 7.954e-137
Identity = 180/324 (55.56%), Postives = 247/324 (76.23%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   30 QQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 353

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 399.823 bits (1026), Expect = 2.975e-136
Identity = 180/324 (55.56%), Postives = 247/324 (76.23%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   57 QQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 380

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 399.438 bits (1025), Expect = 4.876e-136
Identity = 180/324 (55.56%), Postives = 247/324 (76.23%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   30 QQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 353

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 393.275 bits (1009), Expect = 1.094e-133
Identity = 180/333 (54.05%), Postives = 247/333 (74.17%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEK---------LFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K         +F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   51 QQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVSSGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 383

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 393.275 bits (1009), Expect = 1.315e-133
Identity = 180/333 (54.05%), Postives = 247/333 (74.17%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEK---------LFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K         +F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   51 QQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVSSGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 383

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 400.208 bits (1027), Expect = 1.391e-136
Identity = 179/320 (55.94%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 390.963 bits (1003), Expect = 8.400e-133
Identity = 179/333 (53.75%), Postives = 244/333 (73.27%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEK-------------LFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K             +F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSPGAGHFTPGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 386

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 389.808 bits (1000), Expect = 1.229e-131
Identity = 178/322 (55.28%), Postives = 244/322 (75.78%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLF-SDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ++YTD  +IGNG+FGVVY A L +++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL++EY+P+TVY + R + + + + P  Y+K++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F S K  PE I L + LLEY+P  RL+ LE+  +++F+ELR    +LPN    P L +FS  EL+I+PSLN
Sbjct:  117 VAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLN 438

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 389.423 bits (999), Expect = 1.782e-131
Identity = 178/322 (55.28%), Postives = 244/322 (75.78%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLF-SDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ++YTD  +IGNG+FGVVY A L +++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL++EY+P+TVY + R + + + + P  Y+K++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F S K  PE I L + LLEY+P  RL+ LE+  +++F+ELR    +LPN    P L +FS  EL+I+PSLN
Sbjct:  117 VAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLN 438

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Mapk12 (mitogen-activated protein kinase 12 [Source:MGI Symbol;Acc:MGI:1353438])

HSP 1 Score: 182.57 bits (462), Expect = 7.139e-53
Identity = 108/302 (35.76%), Postives = 170/302 (56.29%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIK---RVFQDKRYKNR---ELQIMKMLQHPNVIALLYYFIHNGEKDD-TYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNST----YNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESS 996
            Y D   +G+G +G V  A    +  KVAIK   R FQ + +  R   EL+++K ++H NVI LL  F  +   DD T   L+M ++   +  L++        +    ++   YQML+GL Y+H   ++HRD+KP NL VN E   LK+ DFG A+   S      Y+ +R+YRAPE+IL    YT  +D+WS GC++AEM+ G+ LF G +++DQL EI+KI G+P    ++++ S     Y E  LP++    F  + ++   P+ ++LL  +L     QR+T+ E+L + YF  LR++ 
Sbjct:   27 YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMK-----HETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVN-EDCELKILDFGLARQADSEM--TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYME-GLPELEKKDFASVLTN-ASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESLRDTE 318

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P49841|GSK3B_HUMAN (Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2)

HSP 1 Score: 400.208 bits (1027), Expect = 8.353e-136
Identity = 179/320 (55.94%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9WV60|GSK3B_MOUSE (Glycogen synthase kinase-3 beta OS=Mus musculus OX=10090 GN=Gsk3b PE=1 SV=2)

HSP 1 Score: 400.208 bits (1027), Expect = 9.727e-136
Identity = 179/320 (55.94%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5YJC2|GSK3B_SPECI (Glycogen synthase kinase-3 beta OS=Spermophilus citellus OX=9997 GN=GSK3B PE=2 SV=1)

HSP 1 Score: 399.823 bits (1026), Expect = 1.209e-135
Identity = 179/320 (55.94%), Postives = 243/320 (75.94%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDT-YLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D  YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDVVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q91757|GSK3B_XENLA (Glycogen synthase kinase-3 beta OS=Xenopus laevis OX=8355 GN=gsk3b PE=1 SV=1)

HSP 1 Score: 399.438 bits (1025), Expect = 1.789e-135
Identity = 179/324 (55.25%), Postives = 247/324 (76.23%), Query Frame = 1

Query:  109 QTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            Q  ++YTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT L++  +++F+ELR+ + +LPNG + P+L +F+ +EL+  PSL+
Sbjct:   51 QQEVTYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPIIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTSRLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLS 374

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P18266|GSK3B_RAT (Glycogen synthase kinase-3 beta OS=Rattus norvegicus OX=10116 GN=Gsk3b PE=1 SV=1)

HSP 1 Score: 399.053 bits (1024), Expect = 2.646e-135
Identity = 178/320 (55.62%), Postives = 244/320 (76.25%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG  +P+L +F+ +EL+  P L
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPL 373

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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A067RL75 (Protein kinase domain-containing protein (Fragment) OS=Zootermopsis nevadensis OX=136037 GN=L798_03136 PE=3 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 2.987e-137
Identity = 184/321 (57.32%), Postives = 251/321 (78.19%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L+H N++ L Y+F  +G+K D+ YLNL++EYIP+TVY + R Y +++  IP  ++K++ YQ+ R LAY+H   I HRDIKP NLL++ ETG+LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P++K+F  +  PE I L++ LLEY+P  R++ L++  +T+F+ELRE++ RLPNG + P L +F+ +ELTI PSLN
Sbjct:   25 VSYTDTKVIGNGSFGVVYQAKLCDTGEMVAIKKVLQDKRFKNRELQIMRRLEHCNIVKLKYFFYSSGDKKDEVYLNLVLEYIPETVYKVARHYSKSKQTIPISFIKLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETGVLKLCDFGSAKHLVKGEPNVSYICSRYYRAPELIFGAIDYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRARTPPEAIDLVSRLLEYTPSSRISPLQACAHTFFDELRETNTRLPNGRELPPLFNFTEQELTIMPSLN 345

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: K4U9A8 (Glycogen synthase kinase 3-beta OS=Crassostrea angulata OX=558553 GN=GSK3beta PE=2 SV=1)

HSP 1 Score: 409.453 bits (1051), Expect = 4.075e-137
Identity = 182/321 (56.70%), Postives = 251/321 (78.19%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L +S E VAIK+V QDKR+KNRELQIM+ L+H N++ L Y+F   GEK D+ +LNL++EY+P+TVY + R Y +++  IP  Y+K++ YQ+ R LAY+H + + HRDIKP NLL++ ETG+LKL DFGSAK+LV G+PNV+YICSR+YRAPELI G+++YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L++ LLEY+P  R++ LE+  +T+F+ELR+ S RLPNG + P LL+F+ +EL I+P+LN
Sbjct:   52 VSYTDAKVIGNGSFGVVYQAKLVESNELVAIKKVLQDKRFKNRELQIMRKLEHVNIVKLKYFFYSAGEKKDEVFLNLVLEYVPETVYRVARHYSKSKQTIPVLYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPETGVLKLIDFGSAKVLVRGEPNVSYICSRYYRAPELIFGASDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIQLVSRLLEYTPSARISPLEACAHTFFDELRDPSTRLPNGRELPPLLNFTPQELAIQPNLN 372

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: K1QVX4 (Glycogen synthase kinase-3 beta OS=Crassostrea gigas OX=29159 GN=CGI_10018859 PE=3 SV=1)

HSP 1 Score: 409.453 bits (1051), Expect = 4.075e-137
Identity = 182/321 (56.70%), Postives = 251/321 (78.19%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L +S E VAIK+V QDKR+KNRELQIM+ L+H N++ L Y+F   GEK D+ +LNL++EY+P+TVY + R Y +++  IP  Y+K++ YQ+ R LAY+H + + HRDIKP NLL++ ETG+LKL DFGSAK+LV G+PNV+YICSR+YRAPELI G+++YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L++ LLEY+P  R++ LE+  +T+F+ELR+ S RLPNG + P LL+F+ +EL I+P+LN
Sbjct:   52 VSYTDAKVIGNGSFGVVYQAKLVESNELVAIKKVLQDKRFKNRELQIMRKLEHVNIVKLKYFFYSAGEKKDEVFLNLVLEYVPETVYRVARHYSKSKQTIPVLYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPETGVLKLIDFGSAKVLVRGEPNVSYICSRYYRAPELIFGASDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIQLVSRLLEYTPSARISPLEACAHTFFDELRDPSTRLPNGRELPPLLNFTPQELAIQPNLN 372

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JEK7 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106055186 PE=3 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 4.087e-137
Identity = 181/321 (56.39%), Postives = 251/321 (78.19%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L ++ E VAIK+V QDKR+KNRELQIM+ L+H N++ L Y+F  +GEK D+ +LNL++EY+P+TVY + R Y +++  IP  Y+K++ YQ+ R LAY+H + + HRDIKP NLL++ ETG+LKLCDFGSAK+LV G+PNV+YICSR+YRAPELI G+ +YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y+EFK P++   P+ K+F  +  PE I L++ LLEY+P  R+T LE+  +++F+ELR+ + RLPNG + P L +F+  ELTI P+LN
Sbjct:   25 VSYTDAKVIGNGSFGVVYQAKLTETGELVAIKKVLQDKRFKNRELQIMRKLEHQNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYSKSKQTIPILYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPETGVLKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYSEFKFPQIKAHPWSKVFRPRTPPEAILLVSRLLEYTPSGRITPLEACAHSFFDELRDPACRLPNGRELPQLFNFTPTELTIAPALN 345

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JEJ9 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106055186 PE=3 SV=1)

HSP 1 Score: 408.683 bits (1049), Expect = 5.687e-137
Identity = 181/321 (56.39%), Postives = 251/321 (78.19%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L ++ E VAIK+V QDKR+KNRELQIM+ L+H N++ L Y+F  +GEK D+ +LNL++EY+P+TVY + R Y +++  IP  Y+K++ YQ+ R LAY+H + + HRDIKP NLL++ ETG+LKLCDFGSAK+LV G+PNV+YICSR+YRAPELI G+ +YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y+EFK P++   P+ K+F  +  PE I L++ LLEY+P  R+T LE+  +++F+ELR+ + RLPNG + P L +F+  ELTI P+LN
Sbjct:   36 VSYTDAKVIGNGSFGVVYQAKLTETGELVAIKKVLQDKRFKNRELQIMRKLEHQNIVKLKYFFYSSGEKKDEVFLNLVLEYVPETVYRVARHYSKSKQTIPILYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPETGVLKLCDFGSAKVLVRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYSEFKFPQIKAHPWSKVFRPRTPPEAILLVSRLLEYTPSGRITPLEACAHSFFDELRDPACRLPNGRELPQLFNFTPTELTIAPALN 356

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: gsk3ba (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:103021870])

HSP 1 Score: 402.905 bits (1034), Expect = 8.569e-138
Identity = 181/320 (56.56%), Postives = 245/320 (76.56%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SYTD  +IGNG+FGVVY A LCDS E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +G+K D+ YLNL+++Y+P+TVY + R Y + +  +P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RLT LE+  +++F+ELR+ + +LPNG + PSL +F+ +EL+  PSL
Sbjct:   54 VSYTDTKVIGNGSFGVVYQAKLCDSGEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNIKLPNGREKPSLFNFTTQELSSNPSL 373

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: gsk3ab (glycogen synthase kinase 3 alpha [Source:NCBI gene;Acc:103036469])

HSP 1 Score: 399.438 bits (1025), Expect = 3.350e-136
Identity = 180/321 (56.07%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L DS+E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++Y+P+TVY + R + + +T IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ +T +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ LE+  + +F+ELR+ + RLP+G + P L +FS  EL+I+P LN
Sbjct:   81 VSYTDIKVIGNGSFGVVYQARLIDSQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAISLCSRLLEYTPVTRLSPLEACAHAFFDELRQPNARLPSGRELPMLFNFSPVELSIQPQLN 401

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: gsk3aa (glycogen synthase kinase-3 alpha-like [Source:NCBI gene;Acc:103032471])

HSP 1 Score: 397.127 bits (1019), Expect = 1.957e-135
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++++P+TVY + R + + +T+IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ L++  + +F+ELR+   RLP+G + P L +F+  EL+I+P LN
Sbjct:   75 VSYTDIKVIGNGSFGVVYQARLIDTQELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLIRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPQLFNFTTTELSIQPQLN 395

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000036323.1 (glycogen synthase kinase-3 beta-like [Source:NCBI gene;Acc:103043574])

HSP 1 Score: 396.741 bits (1018), Expect = 2.560e-135
Identity = 178/320 (55.62%), Postives = 241/320 (75.31%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +SY D  +IGNG+FGVVY A LCD+ E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +G+K D+ YLNL+++Y+P+TVY + R Y + + ++P  YVK++ YQ+ R LAY+H   I HRDIKP NLL++ ET +LKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT +IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  K  PE I L + LLEY+P  R T LE+  + +F+ELR  + +LPNG + P L +F+ +EL+  PSL
Sbjct:   53 VSYMDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPKTPPEAIALCSRLLEYTPTARFTPLEACAHAFFDELRVPTLKLPNGRERPPLFNFTTQELSSNPSL 372

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: gsk3aa (glycogen synthase kinase-3 alpha-like [Source:NCBI gene;Acc:103032471])

HSP 1 Score: 396.741 bits (1018), Expect = 2.574e-135
Identity = 176/321 (54.83%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++++P+TVY + R + + +T+IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET +LKLCDFGSAK L+ G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ L++  + +F+ELR+   RLP+G + P L +F+  EL+I+P LN
Sbjct:   75 VSYTDIKVIGNGSFGVVYQARLIDTQELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLIRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPQLFNFTTTELSIQPQLN 395

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 171.014 bits (432), Expect = 4.162e-50
Identity = 109/303 (35.97%), Postives = 172/303 (56.77%), Query Frame = 1

Query:  142 IGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKN------RELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTV--IPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAY---ICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGS------PSANQIREMNSTYNEF---KLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRE 990
            IG GT+GVVY A    + E VA+K++  D   +       RE+ +++ L HPN++ LL   IH+ +K    L L+ E +   +    +K+  N T   IP   VK + YQ+L+G+A+ H  +I+HRD+KP NLL+N E G +KL DFG A+    G P   Y   + + +YRAPE++LG  +Y+ ++DVWS GC+ AEML  RALF G + IDQL  I + +G+      P  +Q+ +  ST+  +   +L K+ P          ++ E   LL  +L+Y P QR+T+  +L + +F  +++
Sbjct:   10 IGEGTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLT-IIHSEKK----LYLVFELLDQDL----KKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAE-GAIKLADFGLARAF--GVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQLPDYKSTFPRWANQELTKVVPT---------LNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNVKQ 291

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: mapk12a (mitogen-activated protein kinase 12a [Source:NCBI gene;Acc:30681])

HSP 1 Score: 172.17 bits (435), Expect = 9.790e-50
Identity = 109/305 (35.74%), Postives = 170/305 (55.74%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIK--------RVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKD---DTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFK-----LPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRE 990
            Y+    +G+G +G V  +    +  KVA+K        RVF  + Y  REL+++K ++H NVI L+  F  N   D   D YL  +M ++   +  +++  +Q+        V+   YQ+L+GL Y+H   I+HRD+KP NL VN E   LK+ DFG A+   + Q    Y+ +R+YRAPE+IL   +YT  +D+WS GC++AEM+ G+ LF G +++DQL+ I+K+ G+P    +  M+   NE       LPKM       +F +  +P  I LL  +L   P QR T+ E+L + +F+E RE
Sbjct:   27 YSQLFAVGSGAYGTVCSSMDLVTGSKVAVKKLYRPFQSRVFAKRAY--RELRLLKHMKHENVIGLVDVFTPNDTLDQFQDFYL--VMPFMGTDLSKIMKHGKQS-----DDKVQYLIYQILKGLKYIHSSGIIHRDLKPGNLAVN-EDCELKILDFGLAR--HADQEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKPLFPGNDHMDQLMLILKLTGTPPQYLVDRMDE--NEAAKYIKTLPKMEKRRISTVFPN-ANPIAIDLLEKMLALDPEQRPTASEALQHPFFSETRE 316

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2])

HSP 1 Score: 168.703 bits (426), Expect = 2.652e-48
Identity = 108/325 (33.23%), Postives = 180/325 (55.38%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRV--FQDKRYKNRELQIMKML---QHPNVIAL--LYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVA----YICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQ---IREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEEL 1056
            YT  + IG G +G+V  A       +VAIK++  F+ + Y  R L+ +K+L   +H N+I +  +       +  D Y+  + + +   +Y L++  +     + + ++  F YQ+LRGL Y+H   ++HRD+KP+NLL+N  T  LK+CDFG A++      +      Y+ +R+YRAPE++L S  YT +ID+WS GC++AEML  R LF G++ +DQL  I+ I+GSPS      I  M +      LP  + +P+ +LF  K D + + LL  +L ++P +R+T  E+L + Y  +  + S       + P   D  L++L
Sbjct:   36 YTSLSYIGEGAYGMVCAAFDNVKLVRVAIKKISPFEHQTYCQRTLREIKILLRFKHENIIGINDILRASTIDQMKDVYI--VQDLMETDLYKLLKGQQ-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPLFPGKHYLDQLNHILGILGSPSQEDLDCIINMKARNYLQSLPPKAKVPWNRLFP-KADSKALDLLDKMLTFNPHRRITVEEALAHPYLEQYYDPSDE--PVAEEPFRFDMELDDL 349

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: cdk7 (cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GENE-010320-2])

HSP 1 Score: 162.54 bits (410), Expect = 3.732e-46
Identity = 96/297 (32.32%), Postives = 160/297 (53.87%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKN---------RELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAY---ICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFN 978
            Y     +G G F  VY A    + + VAIK++    R +          RE+++++ L HPN+I LL  F H      + ++L+ +++ DT  DL    +    V+    +K F    L+GL Y+H   I+HRD+KP NLL++ E G+LKL DFG AK    G P+  Y   + +R+YR+PEL+ G+  Y   +D+W+ GC++AE+LL      G +++DQL +I + +G+P+      M +  +  +       P E +F+   D +++ LL  L  +SP  RLT+ +++   YF+
Sbjct:   26 YDKIDFLGEGQFATVYKAMDKVTNKIVAIKKIKLGHRTEAKDGINRTALREIKLLQELNHPNIIGLLDAFGHK-----SNISLVFDFM-DT--DLEVIVKDTSLVLSPANIKSFMVMTLQGLEYLHMHWILHRDMKPNNLLLD-EQGVLKLADFGLAKSF--GSPSRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRTPFLPGDSDLDQLSKIFEALGTPTEELWPGMTNLPDYVEYKSFPGTPLENIFTAATD-DLLELLQGLFTFSPAARLTATQAMQMPYFS 310

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: mapk14a (mitogen-activated protein kinase 14a [Source:NCBI gene;Acc:65237])

HSP 1 Score: 162.155 bits (409), Expect = 6.068e-46
Identity = 105/302 (34.77%), Postives = 167/302 (55.30%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIK---RVFQD---KRYKNRELQIMKMLQHPNVIALLYYFIHNG---EKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQN----NIDQLVEIIKIMGSPSANQIREMNSTYNE---FKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNE 981
            Y + T +G+G +G V  +    +  KVA+K   R FQ     +   REL+++K ++H NVI L+  F  N    E DD YL  + + +   + ++V+  +     +   +V+   YQ+LRGL Y+H   I+HRD+KP+NL VN E   LK+ DFG A+   +      Y+ +R+YRAPE++L   +Y   +D+WS GC++AE+L GR LF G +    +I+QLV+I+++ G+P    I  M S         LP      F+ +F    +P V+ LL  +L     QR+T+ E+LV+ YF +
Sbjct:   25 YVNLTSVGSGAYGSVCSSLDTKTGMKVAVKKLSRPFQSVIHAKRTYRELRLLKHMKHENVIGLMDVFTPNSSLEEFDDLYL--VTDLMGADLNNIVKCQK-----LTDDHVQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVN-EDCELKILDFGLAR--HADDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDRILSDINQLVKILQLTGTPPQYLIDRMQSKEARNYIQSLPYTQKRDFKDVFL-GANPLVVDLLERMLVLDTDQRITAAEALVHQYFAQ 315

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: RIM11 (Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication [Source:SGD;Acc:S000004747])

HSP 1 Score: 318.931 bits (816), Expect = 1.476e-106
Identity = 150/310 (48.39%), Postives = 213/310 (68.71%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMH-FKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFS 1044
            IS+    ++G+G+FGVV+   + ++ EKVAIK+V QDKR+KNREL+IMKML H N+I L Y+F     +D+ YLNLI+EY+P ++Y  +R +   RT +    +K + +Q+ + L Y+H F  + HRDIKP NLLV+ ET  LKLCDFGSAK L   +PNV+YICSR+YRAPELI G+ NYT  ID+WS+GCV+AE+LLG+ +F G++ IDQLVEIIKI+G+PS  +I  MN  Y E K P++ PIP  ++F  K D + +  L  +L+Y P++R  +L+ L   YF+EL+    ++        LL+F 
Sbjct:   37 ISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFK-KEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFD 345

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MRK1 (Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication [Source:SGD;Acc:S000002237])

HSP 1 Score: 313.153 bits (801), Expect = 1.567e-102
Identity = 146/312 (46.79%), Postives = 211/312 (67.63%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMH-FKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLE 1050
            ISY    ++G+G+FGVV    + ++ +KVAIK+V QD+RYKNREL+ MKML HPN + L YYF    E+D+ YLNL+++Y+P ++Y  +R +   +  +P   +K ++YQ+ + L Y+H   +I HRDIKP NLLV+  T   K+CDFGSAK L   QPNV+YICSR+YRAPEL+ G+ NY+  +DVWS+ CVIAE+LLG+ LFSG++ IDQLVEIIKIMG P+ ++I  MN  Y +   P + PI   ++F  + DP+ + LLT  L+Y P +RL  L+ L+ +YF+E +          ++  + DF +E
Sbjct:  162 ISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAE-DPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDTDTYVKAQNLRIFDFDVE 472

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MCK1 (Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication [Source:SGD;Acc:S000005251])

HSP 1 Score: 259.61 bits (662), Expect = 2.704e-83
Identity = 141/321 (43.93%), Postives = 196/321 (61.06%), Query Frame = 1

Query:  142 IGNGTFGVVYGATLCDSKEK----VAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDD-TYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNE--FKLPKMSPIP---FEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGG----KSPSLLDFSLEELTI 1062
            IG G FG V  A L   K+      AIK+V     YK+RELQI+++  HPN++ L Y+F H   +D+  Y +L ME +P+T+   + +Y  N+  +P +++++++YQ+ RG+ Y+H   + HRDIKP+N+LV+ ETG+LK+CDFGSAK L   QP+++YICSRFYRAPELI+G   YT  ID+W  GCV+ EML+G+A+F GQ  + QL EI K++G P    I   N  Y+   F  P  S      FEK F     P+ I LL  +L Y P QRL+    L + +FNELR     LP G     K P+L DF+  EL I
Sbjct:   41 IGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHS-GPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDDTFLPRGFTEPIKLPNLFDFNDFELQI 360

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: YGK3 (Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005488])

HSP 1 Score: 206.068 bits (523), Expect = 1.193e-62
Identity = 114/320 (35.62%), Postives = 183/320 (57.19%), Query Frame = 1

Query:  142 IGNGTFGVVYGATLCDSKEK----VAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYF-IHNGEKDDTYL---NLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIR---EMNSTYNEFKLPK-MSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKS----PSLLDFSLEE 1053
            IG+G+FG V  + L  +  +     AIKRV +  + ++ EL+I++ ++HPN++ L ++F  H   KD  +L   N +MEYIP T+   + +Y  N + +P++++K++++Q+LR L  +H   I H D+KP+N+L+   +GI K+CDFGSA+ L        Y CSRFYRAPEL+L S +YT  ID+WS GC+I EM+ G+ LF G +   QL EI K++G    + I+   E+  + N+ K  K M   P  + F        +  L  +L Y   +R  + + + + +F+ LR  ++ LP G       P L +FS  E
Sbjct:   47 IGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMHWFPSIEFFD-------VEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASE 359

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103])

HSP 1 Score: 176.792 bits (447), Expect = 6.329e-51
Identity = 106/293 (36.18%), Postives = 167/293 (57.00%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQD------KRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFK----LPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTY 972
            Y D   +G G FG+V  AT   + + VAIK++ +        +   REL+++K L+H N+I L   F+   E  D Y   + E     ++ L+    Q R  +  Q+V+ F YQ+LRGL Y+H   ++HRD+KP+N+L+N E   LK+CDFG A+I         Y+ +R+YRAPE++L    Y   +D+WSAGC+ AEM+ G+ LF G++++ Q   I  ++GSP  + I  + S  N  K    LP   PIPF + F   V+P+ + LL  +L + P +R+T+ ++L + Y
Sbjct:   23 YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLE--DIYF--VTELQGTDLHRLL----QTRP-LEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILIN-ENCDLKICDFGLARI--QDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSE-NTLKFVTSLPHRDPIPFSERFK-TVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO36371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIW0])

HSP 1 Score: 395.201 bits (1014), Expect = 2.594e-135
Identity = 177/321 (55.14%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            ISYTD  +IGNG+FGVVY A +CDS E VAIK+V QDKR+KNRELQIM+ L H N++ L ++F  +G+K ++ YLNL++++IP+TVY + R Y + +  IP  Y+K++ YQ+ R L Y+H   I HRDIKP NLL++ ET +LKLCDFGSAK+LV G+PNV+YICSR+YRAPELI G+ +Y+  IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QI+EMN  Y EFK P++ P P+ K+F  K  PE I+L + LLEY+P  RL ++ES  + +F+ELR+ + +LPNG   P L +F+ +EL++KP+LN
Sbjct:   53 ISYTDTKVIGNGSFGVVYQARMCDSTELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRWFFYSSGDKKEEIYLNLVLDFIPETVYRVARHYSKAKQTIPMLYIKLYMYQLFRSLTYIHCLGICHRDIKPQNLLLDPETAVLKLCDFGSAKVLVKGEPNVSYICSRYYRAPELIFGATDYSPDIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIKEMNPHYTEFKFPQIKPHPWNKVFRPKTPPESINLCSRLLEYTPSGRLNAIESCAHCFFDELRDPNTKLPNGRDLPPLFNFTPQELSVKPALN 373

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO40573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6R5])

HSP 1 Score: 189.504 bits (480), Expect = 8.546e-56
Identity = 122/324 (37.65%), Postives = 182/324 (56.17%), Query Frame = 1

Query:   67 KSTNIKVKFGYKNCQTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKR------VFQDKRYKNRELQIMKMLQHPNVIAL---LYYFIHNGEKDDTYLNL-IMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPN-----VAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNS----TYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNE 981
            K  N ++KF       +I       IGNG +GVV  A    +  KVA+K+      V    R  +REL+I++  +H N+I +   L   ++  E DD Y+ L +ME       DL R    ++ +  +++V+ F YQ+LRGL Y+H  +++HRD+KP+NLLVN E   LK+ DFG A+ L S           Y+ +R+YRAPEL+L    Y+ AID+WS GC++AEM+  R LF G N ++QL  I+ + G+PS N I  M +    TY   +LP   P+PFEK F  K  PE I+LL+ +L+  P +R+T   +L + +  E
Sbjct:    9 KDKNTEIKFVVDARYKLIE-----TIGNGAYGVVCSAMDTRTGAKVAVKKISRAFDVLTTARRTHRELKILRHFKHDNIICIRDILKPPVNLDEFDDVYVVLDLMES------DLHRIIHTDQPLT-TEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVN-ENAELKIGDFGMARGLCSSPLEQKRFMTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLN-QLPHKDPVPFEKFFP-KAHPEAINLLSQMLQLDPKERITVENALQHPFLKE 317

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO45693 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RS71])

HSP 1 Score: 181.03 bits (458), Expect = 4.189e-53
Identity = 108/307 (35.18%), Postives = 177/307 (57.65%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRV-FQDK---RYKNRELQIMKMLQHPNVIALLYYF------IHNGE----KDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYI----CSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIM--GSPSANQIR-EMNSTYNEFKLPKMSPIPFEKLFS--DKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYF 975
            +T+  +IG G  G VY      +  +VA+KRV  QD+   R   R++++ + L+H N++ LL         IHNG+    KD  Y+ L+ E +   ++ ++    Q+ + +   Y K+F YQ+LRGL Y+H   ++HRDIKP+NLLV+ ET +LK+ DFG  +++     +  Y+     + +Y+APEL L S  Y+ AID+W AGCV AEMLLG+ LF G+++I+QL  I+  +   S   N +  +M + +++  L      P E L+S    +DP+ + LL  +L +SP  R+T+ ++L + Y 
Sbjct:   14 FTNLKLIGTGGSGAVYSGIDSKTDRRVALKRVNIQDQSSCRTTLRQIEVQRNLEHENIVKLLNIVDCEGKSIHNGDAENFKDTDYVYLVQEVMETNLHTIL----QSNSSLGQDYSKLFLYQLLRGLKYIHSANVLHRDIKPSNLLVDSETLMLKIGDFGQTRVVDPEFDHDGYLTHSPSTLWYKAPELFLNSTGYSNAIDIWGAGCVFAEMLLGKPLFEGRHDIEQLQLILDTIPVDSKGLNNLEFDMKANFDKMLLDG----PKEPLYSKFQDLDPKALDLLKQMLRFSPESRITAEDALTHPYL 312

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO37435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFQ0])

HSP 1 Score: 178.718 bits (452), Expect = 4.170e-52
Identity = 104/299 (34.78%), Postives = 173/299 (57.86%), Query Frame = 1

Query:  124 YTDKTIIGNGTFGVVYGATLCDSKEKVAIKRV--FQDKRYKNR---ELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVA----YICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQI----REMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNE 981
            YT+   IG G +G+V       + E++AIK++  F+ + Y  R   E++I+   +H N+I +L        +D   + ++   +   +Y L++  R     + + ++  F YQ+LRGL Y+H   ++HRD+KP+NLL+N  T  LK+CDFG A+I      +      Y+ +R+YRAPE++L S  Y+ AID+WS GC++AEML  R LF G++ +DQL  I+ ++GSP A+ +     E   +Y +  LP     PF KLFS+  D + + L+ +LL ++P +R+T  E+L + Y  +
Sbjct:   21 YTNLNYIGEGAYGMVVAGVDNTTGERIAIKKISPFEHQTYCQRTLREIKILSRFKHENIIGILDIIRAPRAEDMKDIYIVQPLMETDMYKLLKTQR-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARIADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLANRPLFPGKHYLDQLNLILNVLGSPIADDLLCIKNEKARSYLQ-SLPYKPKTPFIKLFSN-ADAKALDLIENLLAFNPNKRITVEEALAHPYLEQ 311

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO35402 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ0])

HSP 1 Score: 176.407 bits (446), Expect = 2.079e-51
Identity = 100/298 (33.56%), Postives = 169/298 (56.71%), Query Frame = 1

Query:  121 SYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQ---DKRYKN---RELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNV--AYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGS--PSANQIREMNSTYNEFKLPKMSPI-PFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNE 981
             Y +  ++G G++G+V      DS + VAIK+  +   DK  K    RE+++++ L+H N++ L+  F     +    L L+ E++  TV D + +Y      +    V+   +Q+LR + ++H   I+HRD+KP N+LV+  +GI+KLCDFG A+ L SGQ      Y+ +R+YRAPEL++G   Y  A+DVW+ GC++AEML G  LF G ++IDQL  I++  G+      +I + N  +   +LP +  + P E+ F  ++ P  + +L   L+  P +R T  + L + +F +
Sbjct:    3 KYENLGLVGEGSYGMVMKCRHKDSNQIVAIKKFIESEDDKMVKKIAMREVRMLRQLRHENLVNLIEVF-----RRKKRLFLVFEFVDHTVLDDLERYPNG---LDENTVRKVMWQVLRAIEFIHRHNIIHRDVKPENILVS-RSGIVKLCDFGFARTLASGQGEAYTDYVATRWYRAPELLVGDTKYGRAVDVWAVGCLLAEMLTGEPLFPGDSDIDQLYHIMRCFGNLISRHREIFQKNPLFVGMRLPDIKEVEPMERRFP-RISPMAVDMLKLCLKMDPSERPTCAQLLNHDFFKK 290

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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000027319.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 400.208 bits (1027), Expect = 1.696e-136
Identity = 181/321 (56.39%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  NGEK D+ YLNL+++++P+TVY + R + + +T IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET ILKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ LE+  + +F+ELR+ + RLP+G + P L +FS  EL+I+P LN
Sbjct:   81 VSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLN 401

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 399.053 bits (1024), Expect = 4.866e-136
Identity = 179/321 (55.76%), Postives = 245/321 (76.32%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++++P+TVY + R + + +++IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET ILKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RL+ LE+  + +F+ELR+ + RLP+G   P L +FS  EL+I+P LN
Sbjct:   81 VSYTDVKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSIQPQLN 401

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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000016710.2 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 398.667 bits (1023), Expect = 5.841e-136
Identity = 181/321 (56.39%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  NGEK D+ YLNL+++++P+TVY + R + + +T IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET ILKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ LE+  + +F+ELR+ + RLP+G + P L +FS  EL+I+P LN
Sbjct:   85 VSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLN 405

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000044063.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 400.208 bits (1027), Expect = 5.938e-136
Identity = 181/321 (56.39%), Postives = 246/321 (76.64%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            +SYTD  +IGNG+FGVVY A L D++E VAIK+V QDKR+KNRELQIM+ L H N++ L Y+F  NGEK D+ YLNL+++++P+TVY + R + + +T IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET ILKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P+ RL+ LE+  + +F+ELR+ + RLP+G + P L +FS  EL+I+P LN
Sbjct:  121 VSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLN 441

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 343.584 bits (880), Expect = 8.013e-115
Identity = 153/281 (54.45%), Postives = 212/281 (75.44%), Query Frame = 1

Query:  238 KNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLN 1077
            KNRELQIM+ L H N++ L Y+F  +GEK D+ YLNL+++++P+TVY + R + + +++IP  YVK++ YQ+ R LAY+H + + HRDIKP NLLV+ ET ILKLCDFGSAK LV G+PNV+YICSR+YRAPELI G+ +YT  ID+WSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+P+  QIREMN  Y EFK P++   P+ K+F  +  PE I L + LLEY+P  RL+ LE+  + +F+ELR+ + RLP+G   P L +FS  EL+I+P LN
Sbjct:   87 KNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSIQPQLN 367

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000012496.1 (SMESG000012496.1)

HSP 1 Score: 568.155 bits (1463), Expect = 0.000e+0
Identity = 274/274 (100.00%), Postives = 274/274 (100.00%), Query Frame = 1

Query:  259 MKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH 1080
            MKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH
Sbjct:    1 MKMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH 274

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000012496.1 (SMESG000012496.1)

HSP 1 Score: 564.688 bits (1454), Expect = 0.000e+0
Identity = 272/272 (100.00%), Postives = 272/272 (100.00%), Query Frame = 1

Query:  265 MLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH 1080
            MLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH
Sbjct:    1 MLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNH 272

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 396.356 bits (1017), Expect = 4.061e-135
Identity = 178/320 (55.62%), Postives = 242/320 (75.62%), Query Frame = 1

Query:  118 ISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            ISYTD  IIGNG+FGVVY A  C+SKE VAIK+V QD+R+KNRELQIM+ L+H N++ LL++F  NGEK D+ YLNL++E+IP+TVY + R Y +N+  IP  ++K++ YQ++R LAY+H   I HRDIKP NLLV+ +TG+LKLCDFGSAK+L  G+PNV+YICSR+YRAPELI G+ +YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+PS  QI +MN  Y EFK P +   P+ K+F  +  PE I L+  LLEY+P  R++ +ES  +++F+ELR+ S +LPN    P L +F+  E+  +  L
Sbjct:   49 ISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDL 368

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 396.356 bits (1017), Expect = 6.868e-135
Identity = 181/340 (53.24%), Postives = 247/340 (72.65%), Query Frame = 1

Query:   58 ENEKSTNIKVKFGYKNCQTIISYTDKTIIGNGTFGVVYGATLCDSKEKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            E  + T +    G       ISYTD  IIGNG+FGVVY A  C+SKE VAIK+V QD+R+KNRELQIM+ L+H N++ LL++F  NGEK D+ YLNL++E+IP+TVY + R Y +N+  IP  ++K++ YQ++R LAY+H   I HRDIKP NLLV+ +TG+LKLCDFGSAK+L  G+PNV+YICSR+YRAPELI G+ +YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+PS  QI +MN  Y EFK P +   P+ K+F  +  PE I L+  LLEY+P  R++ +ES  +++F+ELR+ S +LPN    P L +F+  E+  +  L
Sbjct:   29 EGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDL 368

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000019899.1 (SMESG000019899.1)

HSP 1 Score: 266.929 bits (681), Expect = 2.581e-85
Identity = 143/341 (41.94%), Postives = 203/341 (59.53%), Query Frame = 1

Query:  139 IIGNGTFGVVYGATLCDSKEKV-------------AIKRVFQDKRYKNRELQIMKMLQ-HPNVIALLYYF---------------IHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 1074
            +IG GTFG +  A +  +K                AIK+V QD RYKNREL I++ ++ HPN++   YYF                      D YL+L+ME  P+++ DL+ +Y  N  ++   +VKI++YQMLR L Y+H   I HRDIK +NLLVN  +  LKLCDFGSAK L++G  +V+YI SR+YRAPEL+ G+ +YT AIDVWSAGCV+ EML    LF+G + +DQLV++I+++GSPSA+ +  MN +     LP + P P +  F     P+++ LLT +L Y+PI+R      L++  F+ELR       N    PSL  F  EEL++  S+
Sbjct:   36 VIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 369

The following BLAST results are available for this feature:

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
BLAST of Protein kinase domain-containing protein vs. TrEMBL
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GSK3B	1.739e-136	55.94	glycogen synthase kinase 3 beta [Source:HGNC Symbo...	[more]
GSK3B	2.952e-135	55.94	glycogen synthase kinase 3 beta [Source:HGNC Symbo...	[more]
GSK3A	1.848e-133	55.45	glycogen synthase kinase 3 alpha [Source:HGNC Symb...	[more]
GSK3A	1.046e-132	55.45	glycogen synthase kinase 3 alpha [Source:HGNC Symb...	[more]
GSK3A	1.046e-132	55.45	glycogen synthase kinase 3 alpha [Source:HGNC Symb...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk-3	1.040e-122	54.69	Glycogen synthase kinase-3 [Source:UniProtKB/Swis...	[more]
C44H4.6	3.842e-84	40.58	pep chromosome:WBcel235:X:14596476:14599158:-1 gen...	[more]
pmk-1	8.181e-49	34.34	Mitogen-activated protein kinase pmk-1 [Source:Un...	[more]
dyf-5	3.293e-47	32.87	Serine/threonine-protein kinase dyf-5 [Source:Uni...	[more]
dyf-5	3.892e-47	32.87	Serine/threonine-protein kinase dyf-5 [Source:Uni...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sgg	3.692e-131	54.83	gene:FBgn0003371 transcript:FBtr0070475	[more]
sgg	3.997e-131	54.83	gene:FBgn0003371 transcript:FBtr0070469	[more]
sgg	3.997e-131	54.83	gene:FBgn0003371 transcript:FBtr0070472	[more]
sgg	3.997e-131	54.83	gene:FBgn0003371 transcript:FBtr0070473	[more]
sgg	3.997e-131	54.83	gene:FBgn0003371 transcript:FBtr0070468	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk3ba	3.001e-137	56.25	glycogen synthase kinase 3 beta, genome duplicate ...	[more]
gsk3bb	1.070e-136	56.25	glycogen synthase kinase 3 beta, genome duplicate ...	[more]
gsk3ab	1.638e-136	56.07	glycogen synthase kinase 3 alpha b [Source:ZFIN;Ac...	[more]
gsk3aa	1.258e-134	55.45	glycogen synthase kinase 3 alpha a [Source:ZFIN;Ac...	[more]
zgc:171775	3.892e-50	35.33	zgc:171775 [Source:ZFIN;Acc:ZDB-GENE-030131-4309]	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GSK3B	7.954e-137	55.56	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	2.975e-136	55.56	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	4.876e-136	55.56	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	1.094e-133	54.05	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	1.315e-133	54.05	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Gsk3b	1.391e-136	55.94	glycogen synthase kinase 3 beta [Source:MGI Symbol...	[more]
Gsk3b	8.400e-133	53.75	glycogen synthase kinase 3 beta [Source:MGI Symbol...	[more]
Gsk3a	1.229e-131	55.28	glycogen synthase kinase 3 alpha [Source:MGI Symbo...	[more]
Gsk3a	1.782e-131	55.28	glycogen synthase kinase 3 alpha [Source:MGI Symbo...	[more]
Mapk12	7.139e-53	35.76	mitogen-activated protein kinase 12 [Source:MGI Sy...	[more]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P49841\|GSK3B_HUMAN	8.353e-136	55.94	Glycogen synthase kinase-3 beta OS=Homo sapiens OX...	[more]
sp\|Q9WV60\|GSK3B_MOUSE	9.727e-136	55.94	Glycogen synthase kinase-3 beta OS=Mus musculus OX...	[more]
sp\|Q5YJC2\|GSK3B_SPECI	1.209e-135	55.94	Glycogen synthase kinase-3 beta OS=Spermophilus ci...	[more]
sp\|Q91757\|GSK3B_XENLA	1.789e-135	55.25	Glycogen synthase kinase-3 beta OS=Xenopus laevis ...	[more]
sp\|P18266\|GSK3B_RAT	2.646e-135	55.63	Glycogen synthase kinase-3 beta OS=Rattus norvegic...	[more]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A067RL75	2.987e-137	57.32	Protein kinase domain-containing protein (Fragment...	[more]
K4U9A8	4.075e-137	56.70	Glycogen synthase kinase 3-beta OS=Crassostrea ang...	[more]
K1QVX4	4.075e-137	56.70	Glycogen synthase kinase-3 beta OS=Crassostrea gig...	[more]
A0A2C9JEK7	4.087e-137	56.39	Protein kinase domain-containing protein OS=Biomph...	[more]
A0A2C9JEJ9	5.687e-137	56.39	Protein kinase domain-containing protein OS=Biomph...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk3ba	8.569e-138	56.56	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
gsk3ab	3.350e-136	56.07	glycogen synthase kinase 3 alpha [Source:NCBI gene...	[more]
gsk3aa	1.957e-135	54.83	glycogen synthase kinase-3 alpha-like [Source:NCBI...	[more]
ENSAMXT00000036323.1	2.560e-135	55.63	glycogen synthase kinase-3 beta-like [Source:NCBI ...	[more]
gsk3aa	2.574e-135	54.83	glycogen synthase kinase-3 alpha-like [Source:NCBI...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdk2	4.162e-50	35.97	cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN...	[more]
mapk12a	9.790e-50	35.74	mitogen-activated protein kinase 12a [Source:NCBI ...	[more]
mapk1	2.652e-48	33.23	mitogen-activated protein kinase 1 [Source:ZFIN;Ac...	[more]
cdk7	3.732e-46	32.32	cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GEN...	[more]
mapk14a	6.068e-46	34.77	mitogen-activated protein kinase 14a [Source:NCBI ...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
RIM11	1.476e-106	48.39	Protein kinase; required for signal transduction d...	[more]
MRK1	1.567e-102	46.79	Glycogen synthase kinase 3 (GSK-3) homolog; one of...	[more]
MCK1	2.704e-83	43.93	Dual-specificity ser/thr and tyrosine protein kina...	[more]
YGK3	1.193e-62	35.63	Protein kinase related to mammalian GSK-3 glycogen...	[more]
HOG1	6.329e-51	36.18	Mitogen-activated protein kinase involved in osmor...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO36371	2.594e-135	55.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40573	8.546e-56	37.65	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45693	4.189e-53	35.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37435	4.170e-52	34.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35402	2.079e-51	33.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000027319.1	1.696e-136	56.39	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
gsk3aa	4.866e-136	55.76	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
ENSORLT00000016710.2	5.841e-136	56.39	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
ENSORLT00000044063.1	5.938e-136	56.39	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
gsk3aa	8.013e-115	54.45	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000012496.1	0.000e+0	100.00	SMESG000012496.1	[more]
SMESG000012496.1	0.000e+0	100.00	SMESG000012496.1	[more]
SMESG000023764.1	4.061e-135	55.63	SMESG000023764.1	[more]
SMESG000023764.1	6.868e-135	53.24	SMESG000023764.1	[more]
SMESG000019899.1	2.581e-85	41.94	SMESG000019899.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022730 ID=SMED30022730|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1359bp
TGGTTACACAATATAATTGCATTTAAATATTTTAATTAAATTTCAATGAA
TGCTTTAGAAAACGAAAAATCAACAAATATTAAAGTGAAATTTGGTTACA
AGAATTGTCAAACTATAATTTCATATACTGATAAAACAATAATAGGAAAT
GGGACATTTGGAGTTGTATATGGTGCAACGTTATGTGATTCAAAAGAAAA
AGTTGCAATTAAAAGAGTTTTTCAAGATAAAAGATATAAAAATCGAGAAT
TGCAAATAATGAAAATGCTTCAACATCCTAATGTTATAGCCTTACTCTAC
TATTTCATACATAATGGTGAAAAAGACGATACCTACCTCAATTTAATAAT
GGAATATATTCCCGACACAGTATACGATTTAGTAAGAAAATACCGACAAA
ATCGAACAGTTATTCCTAGTCAATATGTGAAGATTTTTTCCTATCAAATG
CTTCGGGGCCTGGCCTATATGCATTTTAAACAAATTGTACACCGAGACAT
TAAACCCACAAATTTGCTTGTAAACATGGAAACTGGGATTCTTAAATTGT
GTGATTTTGGCAGTGCAAAAATTTTGGTTTCTGGACAACCAAATGTGGCC
TATATATGCTCCAGATTCTATCGAGCCCCTGAACTAATTCTTGGTTCTGC
AAATTATACATGTGCTATCGATGTGTGGTCAGCCGGTTGCGTTATTGCTG
AAATGCTGCTAGGTCGAGCACTTTTTTCTGGTCAAAACAATATTGACCAG
CTGGTAGAAATCATAAAGATAATGGGTTCTCCTAGTGCAAATCAAATAAG
AGAAATGAATTCTACTTATAACGAATTTAAATTGCCAAAAATGAGTCCCA
TACCCTTTGAAAAATTATTTTCTGATAAAGTCGATCCAGAAGTCATTCAT
CTTTTGACGCATTTATTGGAATACTCACCGATTCAAAGATTGACTTCTTT
AGAATCGCTGGTTTATACGTATTTCAATGAGTTGAGAGAAAGTTCTTTTC
GACTACCAAATGGTGGCAAATCTCCTTCCTTATTAGATTTCAGTCTCGAA
GAATTAACTATCAAACCTTCATTAAACCATTTATTGAAACCAACGTGACC
AACGAAGAAAATGAAAATTTTTGATTATCTTGTGATTTTGTGACTCACAA
AACAAAGTTTAAGTAACATCAAATAATACAATAGTACCTATTGTAAAGAC
TTTAAACTTTTTAATTAATTAATGATCGGATTTTTCAGACATTGACTCAA
AAACTGATTTTGTGCGCATTCAAGATCAGAGGTACTTTTCAATTTTTTTT
TGATTATTTCTCATATTTTGTGTTTCACTATTTCACTATTTCTCGTAGAA
TCACTTATT

protein sequence of SMED30022730-orf-1

>SMED30022730-orf-1 ID=SMED30022730-orf-1|Name=SMED30022730-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=351bp
MNALENEKSTNIKVKFGYKNCQTIISYTDKTIIGNGTFGVVYGATLCDSK
EKVAIKRVFQDKRYKNRELQIMKMLQHPNVIALLYYFIHNGEKDDTYLNL
IMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHR
DIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILG
SANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQ
IREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLT
SLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNHLLKPT
*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR039192	STKc_GSK3
IPR000719	Prot_kinase_dom
IPR017441	Protein_kinase_ATP_BS
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0050321	tau-protein kinase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0000132	establishment of mitotic spindle orientation
GO:0002119	nematode larval development
GO:0007052	mitotic spindle organization
GO:0007275	multicellular organism development
GO:0007281	germ cell development
GO:0009792	embryo development ending in birth or egg hatching
GO:0016055	Wnt signaling pathway
GO:0016310	phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040010	positive regulation of growth rate
GO:0040011	locomotion
GO:0043652	engulfment of apoptotic cell
GO:0060069	Wnt signaling pathway, regulating spindle positioning
GO:0070986	left/right axis specification
GO:1901076	positive regulation of engulfment of apoptotic cell
GO:1903356	positive regulation of distal tip cell migration

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 27..310 e-value: 7.3E-79 score: 278.0
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 27..309 e-value: 3.4E-63 score: 213.5
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 27..310 score: 42.76
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 14..106 e-value: 1.1E-33 score: 116.6
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 107..349 e-value: 2.3E-68 score: 232.2
None	No IPR available	PIRSF	PIRSF000654	ILK	coord: 6..253 e-value: 6.4E-20 score: 68.8
None	No IPR available	PANTHER	PTHR24057	GLYCOGEN SYNTHASE KINASE-3 ALPHA	coord: 8..349
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 147..159
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 33..56
IPR039192	Glycogen synthase kinase 3, catalytic domain	CDD	cd14137	STKc_GSK3	coord: 25..313 e-value: 0.0 score: 500.107
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 26..332