Expressed conserved protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30022691 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A4E0S481 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_000294 PE=4 SV=1) HSP 1 Score: 150.599 bits (379), Expect = 3.817e-39 Identity = 91/278 (32.73%), Postives = 151/278 (54.32%), Query Frame = 3 Query: 189 VKTEKKQAHILKQSIHIA---YHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNNVNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHLLTSCYLKKWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGI-FSRKEI-----------------DVNAQEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQ 959 V++++ A K+ A YH G F+G+V ++GV +++F + ++D R+ F V + VGLF A + L LEL DS+W A+ ++++GIL I + IH++ SC L+ RKW +L+E+ L +AVI ILI LSLAESEIE+IHD D L +L N L+ + + +A + +G+ + EI ++ ++ L LSPPQ+S+ L IA+EF L +FL L++F+R+ + E+ + + + + Sbjct: 2 VRSDRYAAKTKKRPRRCALATYHTGSVILFIGIVVSIVGVCTNRLFHVYVYDHRKPARFLHVHIPVGLFSQAAEVTWLSLAQEKLTHNLELDDSQWIGARALAVVGILAAICAFVIHIVISC-LQLHRKWSTVLMEVCSLLLAVIAILISLSLAESEIEVIHDQGDNALTRLLVSNRLL-LDNDMKALQAMGQDSGVDLPQTEIALSEEATAVDTSSSAPSTISGGDFALFLSPPQTSFALLIAAEFLILLAFLAVLIYFVRVCEKAEEARKQMRRAE 277
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A068WNW8 (Expressed conserved protein OS=Echinococcus granulosus OX=6210 GN=EgrG_000190500 PE=4 SV=1) HSP 1 Score: 141.354 bits (355), Expect = 4.019e-35 Identity = 92/263 (34.98%), Postives = 139/263 (52.85%), Query Frame = 3 Query: 198 EKKQAHILKQSIHIA---YHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNN--VNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHL-LTSCYLKKWRK-WWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIF-SRKEIDVNA-QEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQ 959 E + H K+ A YH +G+V L GVS ++F+I I+D R P FH + + VGLF + N V +L P L + W AK S+IGI+ + ++ IH+ L CY + K W + +E+ I VI +L+ LSLAESEIE +H+ D L ML N L+ I E S + + + + N+ E+NLVLS P+ S+Y IA++F +L +FL TLV+F+R+S+ E+ + L K + Sbjct: 55 EPRLRHQRKRPRRCAIGCYHASAVILLIGVVVALAGVSSSRLFDIFIYDNRHPPLFHHISIHVGLFDVRGEITGNEANPVVEALAYPPVLDEPSWLTAKAASVIGIIFGLLALIIHVALLCCYRGREDKPWGTVAVEVLFRLITVIGLLVGLSLAESEIEGVHNHGDETLIRMLQANRLLGISAEVDKSAVPSNTDEVHHAPSPLSSNSIAEFNLVLSDPRQSFYFLIAADFISLLAFLMTLVYFVRLSERKEEFRKQLQKAK 317
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A0R3U6M7 (Uncharacterized protein OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS2442 PE=4 SV=1) HSP 1 Score: 139.428 bits (350), Expect = 7.772e-35 Identity = 95/269 (35.32%), Postives = 138/269 (51.30%), Query Frame = 3 Query: 186 SVKTEKKQAHILKQSIHIA---YHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNNVNSLRKPLE----LSDSRWHAAKIMSIIGILTVISSIPIH--LLTSCYLKKWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIFSRKEIDVNAQ--EYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQ 959 V E K H K+ A YH +GLV L G+S +F I ++D R P FH + V VGLF + N + L PLE L + RW AK +II +L + ++ IH LL ++ + W + EL I VI +L+CLSLAESEIE +H+ D L ML N L+ A+ T N+ G +A+ E+NLVLS P+ S+Y+ IA++F L +FL LV+F+R+S+ +E+ + L K + Sbjct: 7 GVNDEPKLRHQRKRPKRFAVGCYHTSAMLLIIGLVVALAGISSSYLFGIFVYDNRHPPLFHHISVHVGLFDIKGDITG--NGSDGLVVPLEYPPILEELRWLIAKASAIIALLFGVLALSIHAFLLCCSRNREDKPWGTVATELFSCLITVIGLLVCLSLAESEIEGVHNHGDETLVRMLQANKLLAFS--AQVDTLANQSGGEQDAPPPRPSAEVAEFNLVLSEPRRSFYVLIAADFVCLLAFLAMLVYFVRLSEREEQLRKQLQKAK 271
BLAST of Expressed conserved protein vs. TrEMBL
Match: W6U8Q9 (Uncharacterized protein OS=Echinococcus granulosus OX=6210 GN=EGR_08300 PE=4 SV=1) HSP 1 Score: 142.124 bits (357), Expect = 8.862e-35 Identity = 93/265 (35.09%), Postives = 140/265 (52.83%), Query Frame = 3 Query: 198 EKKQAHILKQSIHIA---YHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNN--VNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHL-LTSCYLKKWRK-WWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIF-SRKEIDVNA-QEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQHD 965 E + H K+ A YH +G+V L GVS ++F+I I+D R P FH + + VGLF + N V +L P L + W AK S+IGI+ + ++ IH+ L CY + K W + +E+ I VI +L+ LSLAESEIE +H+ D L ML N L+ I E S + + + + N+ E+NLVLS P+ S+Y IA++F +L +FL TLV+F+R+S+ E+ + L K + D Sbjct: 19 EPRLRHQRKRPRRCAIGCYHASAVILLIGVVVALAGVSSSRLFDIFIYDNRHPPLFHHISIHVGLFDVRGEITGNEANPVVEALAYPPVLDEPSWLTAKAASVIGIIFGLLALIIHVALLCCYRGREDKPWGTVAVEVLFRLITVIGLLVGLSLAESEIEGVHNHGDETLIRMLQANRLLGISAEVDKSAVPSNTDEVHHAPSPLSSNSIAEFNLVLSDPRQSFYFLIAADFISLLAFLMTLVYFVRLSERKEEFRKQLQKAKCD 283
BLAST of Expressed conserved protein vs. TrEMBL
Match: A0A087W0E2 (Expressed conserved protein OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000190500 PE=4 SV=1) HSP 1 Score: 140.198 bits (352), Expect = 9.360e-35 Identity = 101/319 (31.66%), Postives = 160/319 (50.16%), Query Frame = 3 Query: 51 IRQRKTSEISIQ----SILRSTGFNF---PYKIY*LKYNLS*YINKSQI*IMSVKTEKKQAHILKQSIHIA---YHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNN--VNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHLLTSCYLK--KWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIF-SRKEIDVNA-QEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQ 959 ++ R S I +Q ++L S G ++ P L+ +NK+ + E + H K+ A YH +G+V L VS ++FEI I+D R P FH + + VGLF + N V +L P L + W AK S+IGI+ + ++ IH+ CY + + + W + +E+ I VI +L+ LSLAESEIE +H+ D L ML N L+ I E S + + + + N+ E+NLVLS P+ S+Y IA++F +L +FL TLV+F+R+S+ E+ + L K + Sbjct: 2 VKSRPKSYIKVQFTALALLTSPGESYLAIPRPDRSLRMAKDGRVNKNASGAVG-NGEPRLRHQRKRPRRCAIGCYHASAVILLIGVVVALASVSSSRLFEIFIYDNRHPPLFHHISIHVGLFDVRGEITGSEANPVVEALAYPPVLDEPSWLTAKAASVIGIIFGLLALIIHVALLCYYRGREDKPWGTVAVEVLFRLITVIGLLVGLSLAESEIEGVHNHGDETLIRMLQANRLLGICAEVDKSAVPSNTGEVHHAPSPLSSNSIAEFNLVLSDPRQSFYFLIAADFISLLAFLMTLVYFVRLSERKEEFRKQLQKAK 319
BLAST of Expressed conserved protein vs. Planmine SMEST
Match: SMESG000024365.1 (SMESG000024365.1) HSP 1 Score: 534.258 bits (1375), Expect = 0.000e+0 Identity = 263/263 (100.00%), Postives = 263/263 (100.00%), Query Frame = 3 Query: 183 MSVKTEKKQAHILKQSIHIAYHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNNVNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHLLTSCYLKKWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIFSRKEIDVNAQEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQHDRA 971 MSVKTEKKQAHILKQSIHIAYHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNNVNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHLLTSCYLKKWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIFSRKEIDVNAQEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQHDRA Sbjct: 1 MSVKTEKKQAHILKQSIHIAYHVGCCAAFLGLVFLLIGVSLHQVFEILIFDQRQSPTFHQVKVKVGLFGNTALLIDQLNNVNSLRKPLELSDSRWHAAKIMSIIGILTVISSIPIHLLTSCYLKKWRKWWIILLELSLLFIAVICILICLSLAESEIELIHDSDDYDLKLMLHRNGLMIIQKEARASTFTNKLTGIFSRKEIDVNAQEYNLVLSPPQSSYYLFIASEFFTLFSFLCTLVFFIRISDLDEKGKGLLHKGQHDRA 263 The following BLAST results are available for this feature:
BLAST of Expressed conserved protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Expressed conserved protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Expressed conserved protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Expressed conserved protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Expressed conserved protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Expressed conserved protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30022691 ID=SMED30022691|Name=Expressed conserved protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1129bpback to top protein sequence of SMED30022691-orf-1 >SMED30022691-orf-1 ID=SMED30022691-orf-1|Name=SMED30022691-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=264bp MSVKTEKKQAHILKQSIHIAYHVGCCAAFLGLVFLLIGVSLHQVFEILIFback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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