IFI30 lysosomal thiol reductase

Overview


Name	IFI30 lysosomal thiol reductase
Smed ID	SMED30022650
Length (bp)	1251

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of IFI30 lysosomal thiol reductase (SMED30022650) t-SNE clustered cells

Violin plots show distribution of expression levels for IFI30 lysosomal thiol reductase (SMED30022650) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of IFI30 lysosomal thiol reductase (SMED30022650) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for IFI30 lysosomal thiol reductase (SMED30022650) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022650

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig20845	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig20845	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig34257	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig34257	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig37685	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022650	h1SMcG0005030	Contig37685	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
gut	SMED30022650	h1SMcG0005030	dd_Smed_v4_2024_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30022650	h1SMcG0005030	dd_Smed_v4_2024_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30022650	h1SMcG0005030	dd_Smed_v4_2024_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30022650	h1SMcG0005030	dd_Smed_v4_2024_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30022650	h1SMcG0005030	dd_Smed_v4_2024_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
goblet cell	SMED30022650	h1SMcG0005030	dd_Smed_v6_2024_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
pigment cell	SMED30022650	h1SMcG0005030	dd_Smed_v6_2024_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Human
Match: IFI30 (IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398])

HSP 1 Score: 97.0561 bits (240), Expect = 1.883e-22
Identity = 55/174 (31.61%), Postives = 86/174 (49.43%), Query Frame = 1

Query:  661 VYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +Y E  C   + F+  +L P   L+   + V L PYG A E+ V+G+WEF CQHG +EC+ N + AC +   +         C+ +  +   +   C + Y   L  D I EC  GD+G  L H  A  T +L P   Y+PW+ +N    +  +D+  T L  L+C  ++ + P
Sbjct:   66 LYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMERSLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTVN---GKPLEDQ--TQLLTLVCQLYQGKKP 234

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Match: C02D5.2 (GILT-like protein C02D5.2 [Source:UniProtKB/Swiss-Prot;Acc:P34276])

HSP 1 Score: 97.8265 bits (242), Expect = 5.816e-23
Identity = 61/185 (32.97%), Postives = 84/185 (45.41%), Query Frame = 1

Query:  640 DNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGF--ITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITN-QSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 1185
            +N + LDVYME +CPDT  F   QL     +LG    I +N+ P+GKA        +E  CQHG  ECQ N ++ C I        Y+P   C+    +     K   E Y  +Y+ + EC  G +G  L       T+SL P + +IPWI+IN     S    A   L   +C   +  P  C 
Sbjct:   76 ENIVKLDVYMEAQCPDTSRFFRQQLKKAWDILGRLNRIELNVIPFGKARCTEKGNDFECQCQHGPTECQINQLMNCVIDRFGFPHRYLPGVLCMQGKYSLDEAMKCVTENYPSEYERMRECASGTRGRRLLALSGQKTASLTPAIDFIPWIVING----SRNSDALYDLTQNVCEAMQPMPSACK 256

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Match: C02D5.2 (GILT-like protein C02D5.2 [Source:UniProtKB/Swiss-Prot;Acc:P34276])

HSP 1 Score: 97.4413 bits (241), Expect = 1.671e-22
Identity = 61/184 (33.15%), Postives = 84/184 (45.65%), Query Frame = 1

Query:  640 DNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGF--ITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAI-SITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQC 1182
            +N + LDVYME +CPDT  F   QL     +LG    I +N+ P+GKA        +E  CQHG  ECQ N ++ C I        Y+P   C+    +     K   E Y  +Y+ + EC  G +G  L       T+SL P + +IPWI+IN     S    A   L   +C   +  P  C
Sbjct:  136 ENIVKLDVYMEAQCPDTSRFFRQQLKKAWDILGRLNRIELNVIPFGKARCTEKGNDFECQCQHGPTECQINQLMNCVIDRFGFPHRYLPGVLCMQGKYSLDEAMKCVTENYPSEYERMRECASGTRGRRLLALSGQKTASLTPAIDFIPWIVING----SRNSDALYDLTQNVCEAMQPMPSAC 315

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Match: F37H8.5 (GILT-like protein F37H8.5 [Source:UniProtKB/Swiss-Prot;Acc:O17861])

HSP 1 Score: 78.5666 bits (192), Expect = 3.885e-16
Identity = 58/196 (29.59%), Postives = 91/196 (46.43%), Query Frame = 1

Query:  613 FSTFQD----ADGDNKLVLDVYMETRCPDTQVFIDDQLVPVT-QLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANF----KTCCEEYNLDYD---LINECFEGDKGNSLQHKYALATSSLVP-KLAYIPWIIINKVFSQSNQDKATTYLKGLICSYF 1161
            F++F D    A  + K+ + V +E  CPD Q F+  QL P+  +    ++ + L P+G A    V       CQHG +EC  N    C I      + +P  SC+ ++L     F    + C E+  +  D   L   C     G  LQ+K A AT+++ P +  ++PW+IIN V   S Q      L  L+C ++
Sbjct:   60 FASFCDKHRAATHNQKINITVLIEALCPDCQNFLTKQLYPIVFKNFANYVNIELVPFGNAK---VLEDGTIKCQHGEEECSINKFEGCFIDSMQDQSPLPTLSCIEESLQKKVEFADAVQQCFEKLQIGGDIQRLTQSCLVSKLGADLQNKAAAATANVWPEQHKFVPWVIINGVSLTSFQG-FQNQLPTLLCEWY 251

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Match: ZK669.2 (pep chromosome:WBcel235:II:7936592:7938583:-1 gene:WBGene00014052.1 transcript:ZK669.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK669.2)

HSP 1 Score: 75.8702 bits (185), Expect = 2.450e-15
Identity = 49/179 (27.37%), Postives = 88/179 (49.16%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNL--YPYGKAD-EKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLM-KNL------NPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSY 1158
            ++ + E+ CPDT  +  + ++PV   L    T+N+  +P+G A   +        NCQHG  ECQ N + AC IS +     Y+P  +C+  KN       + + NF+      +LD + +  C +   G  L  ++      +  +L ++PWI+IN   SQ+ +++    LK ++C +
Sbjct:   76 IEFFGESLCPDTTRYFRNHIMPVWTSLQASSTINITYHPFGLASCRRSAETGIRCNCQHGPAECQLNMLQACVISTLQVPQLYLPIVNCMQGKNKFSSAVDDCIVNFRP---RPDLDENFMARCAQSQLGAKLMMQHGYRQKEVASELDWVPWILINGRRSQAAENQ----LKTIVCQF 247

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Match: pqn-48 (Prion-like-(Q/N-rich)-domain-bearing protein [Source:UniProtKB/TrEMBL;Acc:O76576])

HSP 1 Score: 70.4774 bits (171), Expect = 3.385e-13
Identity = 43/145 (29.66%), Postives = 67/145 (46.21%), Query Frame = 1

Query:  670 ETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLA---NFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVP-KLAYIPWIIIN 1092
            E  CP  Q FI +QL  V     G + + L P+G +    +     F+C HG +EC  N + +C I I      +PF  C  +N+         +TC       Y  I +C++G +G  LQ + A  T S  P  +  +P+++IN
Sbjct:  148 EALCPYCQKFIANQLGSVFNQFQGQLILELVPWGNSR---IMRDGSFSCNHGQKECDANRLQSCVIDILKVKGALPFIVCFERNIQHYGVEHAMQTCSAFIRSQYRQIRQCYDGPRGVQLQREAAQKTMSTRPNPILEVPYLLIN 289

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Match: CG41378 (gene:FBgn0085638 transcript:FBtr0301791)

HSP 1 Score: 107.842 bits (268), Expect = 3.590e-27
Identity = 62/171 (36.26%), Postives = 87/171 (50.88%), Query Frame = 1

Query:  646 KLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQS-TYVPFSSCL-MKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC 1152
            K+V+ VY E  CPD++ F+  QL+P  ++    + V L PYGKA  K  NGK  F+CQHG  ECQ N   ACA  I       +  ++C+ M N +P      C  + N D  +I  CFE  +G  L      +T+SL P + +IP I I+   SQ  Q+     L   +C
Sbjct:   13 KVVVTVYYEALCPDSKYFLTKQLLPTFKIAKSIMEVKLAPYGKAKTKEHNGKITFDCQHGPIECQANIYHACAAEIIEDPLLRLEVATCMIMDNHSPQEAMNKCTSQINFDDSVIQNCFESYRGVDLLKVIGESTNSLRPPITFIPTITIDG--SQGRQESILKDLLSEVC 181

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Match: CG41378 (gene:FBgn0085638 transcript:FBtr0301792)

HSP 1 Score: 107.842 bits (268), Expect = 4.689e-27
Identity = 62/171 (36.26%), Postives = 87/171 (50.88%), Query Frame = 1

Query:  646 KLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQS-TYVPFSSCL-MKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC 1152
            K+V+ VY E  CPD++ F+  QL+P  ++    + V L PYGKA  K  NGK  F+CQHG  ECQ N   ACA  I       +  ++C+ M N +P      C  + N D  +I  CFE  +G  L      +T+SL P + +IP I I+   SQ  Q+     L   +C
Sbjct:   22 KVVVTVYYEALCPDSKYFLTKQLLPTFKIAKSIMEVKLAPYGKAKTKEHNGKITFDCQHGPIECQANIYHACAAEIIEDPLLRLEVATCMIMDNHSPQEAMNKCTSQINFDDSVIQNCFESYRGVDLLKVIGESTNSLRPPITFIPTITIDG--SQGRQESILKDLLSEVC 190

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Match: CG41378 (gene:FBgn0085638 transcript:FBtr0301790)

HSP 1 Score: 107.457 bits (267), Expect = 1.165e-26
Identity = 62/171 (36.26%), Postives = 87/171 (50.88%), Query Frame = 1

Query:  646 KLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQS-TYVPFSSCL-MKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC 1152
            K+V+ VY E  CPD++ F+  QL+P  ++    + V L PYGKA  K  NGK  F+CQHG  ECQ N   ACA  I       +  ++C+ M N +P      C  + N D  +I  CFE  +G  L      +T+SL P + +IP I I+   SQ  Q+     L   +C
Sbjct:   45 KVVVTVYYEALCPDSKYFLTKQLLPTFKIAKSIMEVKLAPYGKAKTKEHNGKITFDCQHGPIECQANIYHACAAEIIEDPLLRLEVATCMIMDNHSPQEAMNKCTSQINFDDSVIQNCFESYRGVDLLKVIGESTNSLRPPITFIPTITIDG--SQGRQESILKDLLSEVC 213

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Match: CG9427 (gene:FBgn0037721 transcript:FBtr0082104)

HSP 1 Score: 94.7449 bits (234), Expect = 2.947e-22
Identity = 62/182 (34.07%), Postives = 94/182 (51.65%), Query Frame = 1

Query:  625 QDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAI-SITNQSTYVPFSSCLMKNLNP-LANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK 1164
            ++    NKL + +  E+ CPD++ F+  QL PV +  G +I + L P+GK+  +  NG   F+CQHG  EC+GN + +C I S  NQ+  V F  C M  L P  +    C  E  L  D+++ C   + G  LQ +  L T    P  ++IP I+ N VF Q  QD +    +G +C   +
Sbjct:   27 REKRQSNKLHITLLYESLCPDSRNFMH-QLGPVYEEFGDYIDILLVPFGKSQSE-RNGAI-FHCQHGPAECKGNRLQSCVINSTANQAAQVKFVVCQM--LAPDYSRIDQCANEAGLLTDVVH-CLSSETGTKLQLQAELVTKQYSP--SFIPTIVYNGVFDQQLQDHSLRDFRGTVCYMLR 200

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Match: CG9427 (gene:FBgn0037721 transcript:FBtr0334619)

HSP 1 Score: 90.8929 bits (224), Expect = 6.640e-21
Identity = 60/176 (34.09%), Postives = 91/176 (51.70%), Query Frame = 1

Query:  643 NKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAI-SITNQSTYVPFSSCLMKNLNP-LANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK 1164
             +L + +  E+ CPD++ F+  QL PV +  G +I + L P+GK+  +  NG   F+CQHG  EC+GN + +C I S  NQ+  V F  C M  L P  +    C  E  L  D+++ C   + G  LQ +  L T    P  ++IP I+ N VF Q  QD +    +G +C   +
Sbjct:   32 KQLHITLLYESLCPDSRNFMH-QLGPVYEEFGDYIDILLVPFGKSQSE-RNGAI-FHCQHGPAECKGNRLQSCVINSTANQAAQVKFVVCQM--LAPDYSRIDQCANEAGLLTDVVH-CLSSETGTKLQLQAELVTKQYSP--SFIPTIVYNGVFDQQLQDHSLRDFRGTVCYMLR 199

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Zebrafish
Match: ifi30 (IFI30 lysosomal thiol reductase [Source:NCBI gene;Acc:336503])

HSP 1 Score: 119.783 bits (299), Expect = 7.600e-31
Identity = 65/188 (34.57%), Postives = 100/188 (53.19%), Query Frame = 1

Query:  622 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +      +K+ + +Y E+ CP  ++F+  QLVP   +L   + ++L PYG A E    GK+ F CQHG  EC GN I  C ++ +   +  V F  C+    + L + + C   Y  D  +D I +C +GD+GN L H+ A+ T +L P   Y+PWI +N   +   QDKA   L  L+CS +K + P
Sbjct:   53 YNSTKAADKVKVSLYYESLCPGCRMFLTSQLVPTLIMLQDIMEIDLVPYGNAQETQAQGKYIFTCQHGEDECLGNMIETCMLNKLGLDAVMVIF--CMESGNDVLKSAQPCLGVYRPDVTWDSIMQCVKGDQGNKLMHENAVKTDALNPPHQYVPWITVNGEHTDDLQDKAMGSLFSLVCSLYKGQKP 238

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Query:  622 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +      +K+ + +Y E+ CP  ++F+  QLVP   +L   + ++L PYG A E    GK+ F CQHG  EC GN I  C ++ +   +  V F  C+    + L + + C   Y  D  +D I +C +GD+GN L H+ A+ T +L P   Y+PWI +N   +   QDKA   L  L+CS +K + P
Sbjct:   53 YNSTKAADKVKVSLYYESLCPGCRMFLTSQLVPTLIMLQDIMEIDLVPYGNAQETQAQGKYIFTCQHGEDECLGNMIETCMLNKLGLDAVMVIF--CMESGNDVLKSAQPCLGVYRPDVTWDSIMQCVKGDQGNKLMHENAVKTDALNPPHQYVPWITVNGEHTDDLQDKAMGSLFSLVCSLYKGQKP 238

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Zebrafish
Match: si:dkey-197i20.6 (si:dkey-197i20.6 [Source:ZFIN;Acc:ZDB-GENE-131127-557])

HSP 1 Score: 112.079 bits (279), Expect = 4.848e-28
Identity = 60/180 (33.33%), Postives = 97/180 (53.89%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYN--LDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK-IRPPQCS 1185
            + +Y E+ C   + F+ +QL P   LL   + VNL P+G A E  V  +  F+CQHG  EC  N + AC +     + + P   C+  + +   + K C + Y   + ++ I  C  G+ G+SL H+ A+ T +L P   ++PWI IN  ++   +DKA + L  L+CS +K I+PP C+
Sbjct:   69 ISLYYESLCSGCRAFLTEQLFPTWTLLKDIMKVNLVPFGNAKE--VPEENSFSCQHGEPECYANMVEACVLYEATHAAF-PVIHCMESSADVTQSAKPCLQLYAPFIKWETIESCTRGELGHSLMHQNAVKTQALKPAHTHVPWITINGKYTSELEDKAMSTLFNLVCSLYKGIKPPVCT 245

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Xenopus
Match: nxpe3 (neurexophilin and PC-esterase domain family member 3 [Source:Xenbase;Acc:XB-GENE-949458])

HSP 1 Score: 116.701 bits (291), Expect = 1.043e-29
Identity = 65/198 (32.83%), Postives = 98/198 (49.49%), Query Frame = 1

Query:  595 QAASGCFSTFQDAD----GDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQ-STYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKI 1167
            Q    C   + + D     +  + +D++ E+ C   + F+  QL P   +L   I V L PYG A E  + GKW F+CQHG +EC GN + AC I I +    Y P   C+  + N   + ++C   Y   L    + EC  GD GN L H+ A  T  L P   Y+PWI+I+ + +   Q +A + L  L+C  +K+
Sbjct:   37 QVEKQCLEFYSNRDLKKSSEPAIQIDLFYESLCGGCRGFLVRQLFPSWLMLAEIINVTLVPYGNAQETNITGKWVFDCQHGPEECLGNMMEACLIHILDDIYKYFPIIFCMESSNNITKSLESCLAVYAPELPLKTVLECVNGDLGNKLMHENAQKTKGLSPPHNYVPWIVIDGMHTDDLQAQAQSSLFNLVCDTYKV 234

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Xenopus
Match: nxpe3 (neurexophilin and PC-esterase domain family member 3 [Source:Xenbase;Acc:XB-GENE-949458])

HSP 1 Score: 116.701 bits (291), Expect = 1.642e-29
Identity = 66/202 (32.67%), Postives = 99/202 (49.01%), Query Frame = 1

Query:  595 QAASGCFSTFQDAD----GDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQ-STYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQ 1179
            Q    C   + + D     +  + +D++ E+ C   + F+  QL P   +L   I V L PYG A E  + GKW F+CQHG +EC GN + AC I I +    Y P   C+  + N   + ++C   Y   L    + EC  GD GN L H+ A  T  L P   Y+PWI+I+ + +   Q +A + L  L+C  +K   P+
Sbjct:   37 QVEKQCLEFYSNRDLKKSSEPAIQIDLFYESLCGGCRGFLVRQLFPSWLMLAEIINVTLVPYGNAQETNITGKWVFDCQHGPEECLGNMMEACLIHILDDIYKYFPIIFCMESSNNITKSLESCLAVYAPELPLKTVLECVNGDLGNKLMHENAQKTKGLSPPHNYVPWIVIDGMHTDDLQAQAQSSLFNLVCDTYKGPKPE 238

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Mouse
Match: Ifi30 (Gamma-interferon-inducible lysosomal thiol reductase [Source:UniProtKB/Swiss-Prot;Acc:Q9ESY9])

HSP 1 Score: 87.4261 bits (215), Expect = 3.371e-19
Identity = 44/149 (29.53%), Postives = 73/149 (48.99%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINK 1095
            + +Y E+ C   + F+   L P   ++   + + L PYG A E+ V+G WEF CQHG  EC+ N + AC +    +        C+ +  +       C + Y   +  + I EC  G +G  L H+ A  T +L P   Y+PW+++N+
Sbjct:   61 VSLYYESLCGACRYFLVRDLFPTWLMVMEIMNITLVPYGNAQERNVSGTWEFTCQHGELECRLNMVEACLLDKLEKEAAFLTIVCMEEMDDMEKKLGPCLQVYAPEVSPESIMECATGKRGTQLMHENAQLTDALHPPHEYVPWVLVNE 209

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Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINK 1095
            + +Y E+ C   + F+   L P   ++   + + L PYG A E+ V+G WEF CQHG  EC+ N + AC +    +        C+ +  +       C + Y   +  + I EC  G +G  L H+ A  T +L P   Y+PW+++N+
Sbjct:   61 VSLYYESLCGACRYFLVRDLFPTWLMVMEIMNITLVPYGNAQERNVSGTWEFTCQHGELECRLNMVEACLLDKLEKEAAFLTIVCMEEMDDMEKKLGPCLQVYAPEVSPESIMECATGKRGTQLMHENAQLTDALHPPHEYVPWVLVNE 209

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BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Match: sp|E7E2N8|GILT_CARAU (Gamma-interferon-inducible lysosomal thiol reductase OS=Carassius auratus OX=7957 GN=ifi30 PE=1 SV=1)

HSP 1 Score: 120.168 bits (300), Expect = 4.125e-30
Identity = 65/178 (36.52%), Postives = 92/178 (51.69%), Query Frame = 1

Query:  649 LVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            + + +Y E+ CP  + F+  QLVP   +L   + + L PYG A EK   G + F CQHG  EC+GN I  C +        +P   C+    + L   + C   Y  D  +D + +C  GD+GN L H+ AL T++L P   Y+PWI IN   +   QDKAT  L  L+CS +K   P
Sbjct:   58 VTVSLYYESLCPGCREFLVSQLVPTFIMLSDIMNIELVPYGNAQEKDDQGNYTFICQHGEDECRGNMIETCLLKALGPKA-IPVIFCMESGADVLKAAQPCLGVYFPDTTWDSVMKCVTGDEGNKLMHQNALKTNALKPPHEYVPWITINGEHTDDLQDKATNSLFNLVCSLYKGEKP 234

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BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Match: sp|Q5XJN2|GILT_DANRE (Gamma-interferon-inducible lysosomal thiol reductase OS=Danio rerio OX=7955 GN=ifi30 PE=1 SV=1)

HSP 1 Score: 119.783 bits (299), Expect = 5.737e-30
Identity = 65/188 (34.57%), Postives = 100/188 (53.19%), Query Frame = 1

Query:  622 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +      +K+ + +Y E+ CP  ++F+  QLVP   +L   + ++L PYG A E    GK+ F CQHG  EC GN I  C ++ +   +  V F  C+    + L + + C   Y  D  +D I +C +GD+GN L H+ A+ T +L P   Y+PWI +N   +   QDKA   L  L+CS +K + P
Sbjct:   53 YNSTKAADKVKVSLYYESLCPGCRMFLTSQLVPTLIMLQDIMEIDLVPYGNAQETQAQGKYIFTCQHGEDECLGNMIETCMLNKLGLDAVMVIF--CMESGNDVLKSAQPCLGVYRPDVTWDSIMQCVKGDQGNKLMHENAVKTDALNPPHQYVPWITVNGEHTDDLQDKAMGSLFSLVCSLYKGQKP 238

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BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Match: sp|A6QPN6|GILT_BOVIN (Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus OX=9913 GN=IFI30 PE=2 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 3.372e-24
Identity = 57/176 (32.39%), Postives = 86/176 (48.86%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            + +Y E  CP  + F+  +L P   ++   + V L PYG A E+ V+GKWEF CQHG +EC  N + AC +    Q        CL +  +   N K C + Y   +  D I EC  G++G  L H  A  T +L P   Y+PW+++N         K   +L  L+C  ++ + P
Sbjct:   58 VSLYYEALCPGCREFLIRELFPTWLMVLEILNVTLVPYGNAQERNVSGKWEFTCQHGERECLLNKVEACLLDQLEQKIAFLTIVCLEEMDDMEQNLKPCLQIYAPKVSADSIMECATGNRGMQLLHINAQLTDALRPPHKYVPWVVVN-----GEHMKDAEHLLHLVCRLYQGQKP 228

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BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Match: sp|B3SP85|GILT_PIG (Gamma-interferon-inducible-lysosomal thiol reductase OS=Sus scrofa OX=9823 GN=IFI30 PE=2 SV=1)

HSP 1 Score: 98.2117 bits (243), Expect = 3.481e-22
Identity = 57/197 (28.93%), Postives = 95/197 (48.22%), Query Frame = 1

Query:  595 QAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIIN-KVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +A   C            + +++Y E+ C   + F+  +L P   ++   + V L PYG A E+ V+G+WEF CQHG QEC+ N + AC +    ++       C+ +  +   N + C + Y   +  D I EC  GD+G  L H  A  T +L P   Y+PW+++N K  ++ +Q      L  L+C  ++   P
Sbjct:   40 KAGEPCLQRPVGKSDPPPVNVNLYYESLCNGCRYFLVRELFPTWLMVWEILNVTLVPYGNAQERNVSGRWEFTCQHGEQECKMNKVEACLLDKLEKNMAFLTIVCIEELDDMEKNLEPCLQIYAPKVSPDSIMECAMGDRGMQLLHINAQLTDALKPPHEYVPWVVVNGKPMTEKDQ------LLRLVCQLYEGEKP 230

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BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Match: sp|P13284|GILT_HUMAN (Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3)

HSP 1 Score: 97.0561 bits (240), Expect = 9.044e-22
Identity = 55/174 (31.61%), Postives = 86/174 (49.43%), Query Frame = 1

Query:  661 VYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            +Y E  C   + F+  +L P   L+   + V L PYG A E+ V+G+WEF CQHG +EC+ N + AC +   +         C+ +  +   +   C + Y   L  D I EC  GD+G  L H  A  T +L P   Y+PW+ +N    +  +D+  T L  L+C  ++ + P
Sbjct:   66 LYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMERSLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTVN---GKPLEDQ--TQLLTLVCQLYQGKKP 234

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BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Match: A0A3G3LPG6 (Gamma-interferon-inducible lysosomal thiol reductase OS=Dugesia japonica OX=6161 GN=GILT PE=2 SV=1)

HSP 1 Score: 311.612 bits (797), Expect = 2.847e-102
Identity = 145/209 (69.38%), Postives = 172/209 (82.30%), Query Frame = 1

Query:  562 MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKI-RPPQCS 1185
            M   L I LI  A SGC+S    AD   KL+LDVYMETRCPDTQVFIDDQLVPVT+LLG ++ V LYPYGKA+EKFV  KWEF CQHG  ECQGNTILACAIS+TNQS YVPF+SCLM++LNPL+NF++CCE++ LD +L+N+CF+G KGN LQH YALATSSLVPKL YIPWII+NKV++Q+NQD+A T LK LIC + K+  PP+CS
Sbjct:    1 MKIILSIILIYHAVSGCYSKISQAD---KLLLDVYMETRCPDTQVFIDDQLVPVTKLLGNYVEVTLYPYGKAEEKFVGNKWEFICQHGPLECQGNTILACAISMTNQSIYVPFTSCLMRDLNPLSNFRSCCEQFKLDLNLVNKCFQGQKGNELQHHYALATSSLVPKLVYIPWIILNKVYTQANQDQAATNLKALICKHIKVPPPPECS 206

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BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Match: A7SMR3 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g246231 PE=4 SV=1)

HSP 1 Score: 141.739 bits (356), Expect = 4.748e-36
Identity = 74/213 (34.74%), Postives = 118/213 (55.40%), Query Frame = 1

Query:  562 MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISI-TNQSTYVPFSSCL---MKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC-SYFKIRPPQCS 1185
            M++   +F ++  A G F  +  A    K+ + +Y E+ CP  + FI DQL P  Q +G  + + L PYG A +     KW F+CQHG  EC+GN I +CAI+I  N +TY PF  C    + + NP +  + C +   +DY  I++C  G +GN  +H   + T +L P+  ++PW+ +N   ++  Q++ATT L  L+C SY   +P  C+
Sbjct:    1 MAYVNAVFAVALIA-GVFPVYSQAA--PKVSIALYYESLCPGCRAFISDQLYPTYQKIGEIMDITLVPYGNAQQYKYGNKWVFSCQHGQGECEGNIIESCAINILQNLTTYFPFIHCFEQYISSSNPSSTARYCAQLLRIDYTPIDKCASGPQGNQFEHDMGVKTEALEPQHQFVPWVTMNGKHTEEIQNEATTELLKLVCDSYQGAKPAACT 210

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BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Match: A0A2P2I298 (Gamma-interferon-inducible lysosomal thiol reductase-like OS=Hirondellea gigas OX=1518452 PE=2 SV=1)

HSP 1 Score: 141.354 bits (355), Expect = 6.824e-36
Identity = 72/180 (40.00%), Postives = 106/180 (58.89%), Query Frame = 1

Query:  646 KLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADE-KFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKN-LNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            ++ L+VYMET CPD + F  +QL P  + L   + V +YPYG A E     G + F CQ+G  ECQGN +LACA   I N  T+V +S C+M++   P+   K C E+ N+D+D I  C    +G+ + H+ A+AT +L PK  Y+PW++IN + ++  Q  A + LK  IC  +   PP
Sbjct:   42 RVKLEVYMETMCPDCRGFFHEQLAPTWKQLRSIMDVEIYPYGNAKETPLSGGGYNFTCQNGPLECQGNMMLACAQKYIHNNPTFVDYSICVMEDSKTPIRTGKKCAEQLNVDFDPILMCSLSREGDEVLHEVAVATDNLQPKHTYVPWMVINNIHTEEIQSAALSDLKKYICGVYTGAPP 221

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BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Match: A0A2B4SSD0 (Gamma-interferon-inducible lysosomal thiol reductase OS=Stylophora pistillata OX=50429 GN=IFI30 PE=4 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 1.430e-35
Identity = 81/220 (36.82%), Postives = 118/220 (53.64%), Query Frame = 1

Query:  556 NIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKNL----NPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS*KYKF 1200
             +++++LL  + S A+S         D   K+ L +Y E+ CPD Q+FI  QL P    +   + + L PYG A+E+    KW F CQHG +EC+GN I  CAIS + N S  +PF  C  KN+     P A  +TC +   +DYD I  C  G  GN L+HK A  T +L P+  Y+PW+ +N   ++  Q+KA   L  L+C Y+    P+   K +F
Sbjct:    3 GLLAWSLLCLVPSIASSF-------PDDAPKVELALYYESLCPDCQLFIRQQLYPTYLKVSDILDLTLVPYGNAEERKSGDKWVFQCQHGPKECEGNLIETCAISLLKNISASLPFVYCFEKNIEGSEEPKAVAETCAKSLKIDYDSIEACVSGSLGNELEHKMAAMTDALEPQHQYVPWVTVNGKHTEKIQNKAERNLLELVCEYYTGTKPKPCEKQEF 215

HSP 2 Score: 134.42 bits (337), Expect = 4.952e-31
Identity = 77/223 (34.53%), Postives = 114/223 (51.12%), Query Frame = 1

Query:  550 CFNIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISI-TNQSTYVPFSSCLMKNL---NPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK-IRPPQCS*KYKFI 1203
            C   M   L I  +  AA   F     A    K+ + +Y E+ C   + FI+ Q  P    +G  + V L PYG A E     +W F CQHG  EC GN I  CAISI  N +++ PF  CL   +   NP++  + C  +  +D+  I++C  G +GN+L+H+ AL T++L P   ++PWI +N   +   Q++AT  L GL+C  +K  +P  C  K   I
Sbjct:  259 CRGKMKIKLYILFVLLAALPVFCVGAPAAAP-KVEIALYYESLCGGCRQFIETQFYPTFLKVGQIMDVTLVPYGNAQESRTGDEWRFTCQHGEAECVGNIIETCAISILQNATSFFPFIHCLESTIAEYNPVSAAEQCAGQLGIDFSSIDKCQSGAQGNALEHEMALKTNALNPPHYFVPWITLNGKHTDEIQNRATFDLLGLVCDTYKGTKPDACQKKESAI 480

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BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Match: A7SMR2 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g191409 PE=4 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 3.643e-35
Identity = 68/184 (36.96%), Postives = 103/184 (55.98%), Query Frame = 1

Query:  649 LVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISI-TNQSTYVPFSSC---LMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC-SYFKIRPPQCS 1185
            + + +Y E+ C   +  I DQL P  Q +G  + + L PYG A E     KW FNCQHG  EC+GN I  CAI++  N S Y PF  C    + + NP +  + C ++  +DY  I +C  G +GN L+H+  + T +LVP+  Y+PW+ +N   ++  Q++AT  + GL+C +Y   RP  C 
Sbjct:    6 VAISLYYESMCGGCRDMIRDQLYPTFQKVGSIMDITLVPYGNAQEYRYGNKWVFNCQHGQGECEGNIIEVCAINVLKNISAYFPFIHCFEQFISSYNPSSTAQYCAKQLGIDYAPIEKCASGLQGNELEHEMGVETDALVPRHNYVPWVTLNGEHTEEIQNQATFNMLGLVCDNYQGARPAACG 189

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Cavefish
Match: si:dkey-197i20.6 (IFI30 lysosomal thiol reductase [Source:NCBI gene;Acc:103047207])

HSP 1 Score: 112.849 bits (281), Expect = 2.209e-28
Identity = 62/181 (34.25%), Postives = 100/181 (55.25%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYN---LDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK-IRPPQCS 1185
            + VY E+ CP  + F+ +QL P   +L   +TV+L PYG A+E  + G+  F CQHG   C+ N   AC +++T Q+ + P   C M + + + N    C + N   ++++ I  C  G  G+SL H+  + T SL P   Y+PW+  N V+    +DKA + L  L+C  ++ I+PP C+
Sbjct:   68 VTVYYESLCPGCRSFLTEQLFPTWTMLKDIMTVHLVPYGNAEE--IPGQNSFLCQHGEPGCKANVFEACILNVTGQAAF-PVIYC-MASSSDVINAALPCLQLNAPSVEWEAIQSCVIGGLGHSLMHENGVKTRSLKPAHKYVPWVTFNGVYKDDWEDKAMSSLFNLVCMLYEGIKPPVCT 244

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Cavefish
Match: ENSAMXT00000037267.1 (gamma-interferon-inducible lysosomal thiol reductase-like [Source:NCBI gene;Acc:103023905])

HSP 1 Score: 111.694 bits (278), Expect = 7.598e-28
Identity = 60/188 (31.91%), Postives = 94/188 (50.00%), Query Frame = 1

Query:  610 CFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKI 1167
            CF           + + +Y E+ CP  + F+  QL+P   +L   + V L PYG A E    G + + CQHG +EC GN I  C ++      Y+   +C+  +++ L   K C E +     +D I +C  G +GN L H  A+ T +L P   Y+PW+ +N   S+  Q KA + L  L+CS +K+
Sbjct:   53 CFGANVTKSSAPPVNISLYYESLCPGCRQFLVLQLMPTFFMLNDIMNVELVPYGNAQETGPPGNYVYTCQHGPEECTGNMIETCMLNKMGDDAYLAI-NCMEMSVDVLKAAKPCSELFTEKSYWDDIQKCVSGAEGNKLMHLNAVKTGALKPPHEYVPWVTVNGEHSEDLQQKAMSSLFNLVCSLYKV 239

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Cavefish
Match: ENSAMXT00000042139.1 (gamma-interferon-inducible lysosomal thiol reductase-like [Source:NCBI gene;Acc:103023905])

HSP 1 Score: 110.923 bits (276), Expect = 1.305e-27
Identity = 62/195 (31.79%), Postives = 97/195 (49.74%), Query Frame = 1

Query:  610 CFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLD--YDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKI-RPPQCS 1185
            CF           + + +Y E+ CP  + F+  QL+P   +L   + V L PYG A E    G + + CQHG +EC GN I  C ++      Y+   +C+  +++ L   K C E +     +D I +C  G +GN L H  A+ T +L P   Y+PW+ +N   S+  Q KA + L  L+CS +K  +P  C+
Sbjct:   53 CFGANVTKSSAPPVNISLYYESLCPGCRQFLVLQLMPTFFMLNDIMNVELVPYGNAQETGPPGNYVYTCQHGPEECTGNMIETCMLNKMGDDAYLAI-NCMEMSVDVLKAAKPCSELFTEKSYWDDIQKCVSGAEGNKLMHLNAVKTGALKPPHEYVPWVTVNGEHSEDLQQKAMSSLFNLVCSLYKGDKPAACT 246

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BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Sea Lamprey
Match: IFI30 (IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398])

HSP 1 Score: 124.79 bits (312), Expect = 3.962e-34
Identity = 69/194 (35.57%), Postives = 93/194 (47.94%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAIS-ITNQSTYVPFSSCLMKNLNPLANFKTCCE--EYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS*KYKFIL*RKIIFC 1227
            L++Y E+ CP  + F   QL     LLG  + V L PYG A EK    KW F CQHG  EC GN + AC I  + N + +VP   C+    NP++    C       L++  +  C  G  GN L H  A  T +L P   Y+PWI+ N   ++  Q+KA   L  ++CS +K   P    K    L RK   C
Sbjct:    5 LELYAESLCPGCRAFTTGQLYGTWLLLGDIMNVTLVPYGNAQEKHDGDKWVFTCQHGPNECLGNLLQACLIHYLPNNADHVPIIYCMEAAENPVSAASQCAALLAPTLNWQQVETCANGTLGNQLMHSNAQLTDALNPPHKYVPWIVFNGAHTEEIQNKAMEALLPMVCSAYKGELPAACGKLTHCLKRKCKLC 198

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Nematostella
Match: EDO35014 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMR3])

HSP 1 Score: 141.739 bits (356), Expect = 6.567e-40
Identity = 74/213 (34.74%), Postives = 118/213 (55.40%), Query Frame = 1

Query:  562 MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISI-TNQSTYVPFSSCL---MKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC-SYFKIRPPQCS 1185
            M++   +F ++  A G F  +  A    K+ + +Y E+ CP  + FI DQL P  Q +G  + + L PYG A +     KW F+CQHG  EC+GN I +CAI+I  N +TY PF  C    + + NP +  + C +   +DY  I++C  G +GN  +H   + T +L P+  ++PW+ +N   ++  Q++ATT L  L+C SY   +P  C+
Sbjct:    1 MAYVNAVFAVALIA-GVFPVYSQAA--PKVSIALYYESLCPGCRAFISDQLYPTYQKIGEIMDITLVPYGNAQQYKYGNKWVFSCQHGQGECEGNIIESCAINILQNLTTYFPFIHCFEQYISSSNPSSTARYCAQLLRIDYTPIDKCASGPQGNQFEHDMGVKTEALEPQHQFVPWVTMNGKHTEEIQNEATTELLKLVCDSYQGAKPAACT 210

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Nematostella
Match: EDO35033 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMR2])

HSP 1 Score: 138.272 bits (347), Expect = 5.038e-39
Identity = 68/184 (36.96%), Postives = 103/184 (55.98%), Query Frame = 1

Query:  649 LVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISI-TNQSTYVPFSSC---LMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLIC-SYFKIRPPQCS 1185
            + + +Y E+ C   +  I DQL P  Q +G  + + L PYG A E     KW FNCQHG  EC+GN I  CAI++  N S Y PF  C    + + NP +  + C ++  +DY  I +C  G +GN L+H+  + T +LVP+  Y+PW+ +N   ++  Q++AT  + GL+C +Y   RP  C 
Sbjct:    6 VAISLYYESMCGGCRDMIRDQLYPTFQKVGSIMDITLVPYGNAQEYRYGNKWVFNCQHGQGECEGNIIEVCAINVLKNISAYFPFIHCFEQFISSYNPSSTAQYCAKQLGIDYAPIEKCASGLQGNELEHEMGVETDALVPRHNYVPWVTLNGEHTEEIQNQATFNMLGLVCDNYQGARPAACG 189

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Nematostella
Match: EDO41893 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S332])

HSP 1 Score: 85.8853 bits (211), Expect = 7.814e-20
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1

Query:  646 KLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYV-PFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK 1164
            K+ L VY  ++ P+ + F+  QL P +  +   + +++ P+G   E      +++ C +G++EC  N I ACA++  N    +  F  CL      +      C     DY+ +  C +  +G  + H  A  T  L PK+++ PWI +N   S+  Q +A   L  L+CS +K
Sbjct:    3 KVKLAVYYNSKNPEFRRFMVAQLYPTSNKIPNILDISMVPFGDGKEIKAKSGFQYYCTNGAEECLENLIQACAVATENNPEILTSFVGCLSYYDGSVDKIAKYCSNQIKDYEKVEYCLKNTQGLEVMHYMAKKTRGLQPKMSHSPWITVNGEHSEFIQQQAMENLLQLVCSKYK 176

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Medaka
Match: ifi30 (gamma-interferon-inducible lysosomal thiol reductase [Source:NCBI gene;Acc:101164924])

HSP 1 Score: 127.487 bits (319), Expect = 1.248e-33
Identity = 67/176 (38.07%), Postives = 99/176 (56.25%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYN--LDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPP 1176
            + +Y E+ CP  + F+ + ++P   LL   +TV+L P+G A EK    K+ F CQHG  ECQGN I  C +++TN +   P   C+  + + L + ++C + Y   L  D +N C +GD GN L H+ AL T+ L P   Y+PW+ IN   S   Q KA+T L  L+CS +K   P
Sbjct:   61 VGLYYESLCPGCREFLVEMIMPTWILLNDIMTVHLVPFGNAQEKTEGQKYVFECQHGEDECQGNLIETCLLNMTNMA--FPIIFCMESSTDVLGSVESCLKVYEPQLSMDKLNGCVKGDLGNQLMHQNALQTAGLKPPHQYVPWVTINGEHSDDLQQKASTSLFSLVCSLYKGPKP 234

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Medaka
Match: si:dkey-197i20.6 (IFI30 lysosomal thiol reductase [Source:NCBI gene;Acc:101167441])

HSP 1 Score: 119.013 bits (297), Expect = 1.358e-30
Identity = 60/180 (33.33%), Postives = 98/180 (54.44%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK-IRPPQCS 1185
            + +Y ET CPD ++FI +QL P   +L   ++V L PYG A E   +    F CQHG  EC+GN I AC + +T  S       C+  + + L+  + C   Y  ++ +  +N C  GD G  L H  A+ T +L P   ++PW+  N  +++ N++KA + L  L+C  ++ ++PP C+
Sbjct:   69 ITLYYETLCPDCRIFISEQLFPTWLMLKDIMSVTLVPYGNAQE-VQSPTSSFICQHGEPECKGNMIQACILHLTTNSLAFQIIYCMESSADVLSAAQPCLHLYAPSVSWSSVNSCVSGDLGFRLMHGNAVMTRALNPPHTHVPWVTFNGEYTEENEEKAMSSLFHLVCELYQGVKPPACT 247

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Medaka
Match: si:dkey-197i20.6 (IFI30 lysosomal thiol reductase [Source:NCBI gene;Acc:101167441])

HSP 1 Score: 112.464 bits (280), Expect = 3.964e-28
Identity = 57/172 (33.14%), Postives = 92/172 (53.49%), Query Frame = 1

Query:  655 LDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY--NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFK 1164
            + +Y ET CPD ++FI +QL P   +L   ++V L PYG A E   +    F CQHG  EC+GN I AC + +T  S       C+  + + L+  + C   Y  ++ +  +N C  GD G  L H  A+ T +L P   ++PW+  N  +++ N++KA + L  L+C  ++
Sbjct:   69 ITLYYETLCPDCRIFISEQLFPTWLMLKDIMSVTLVPYGNAQE-VQSPTSSFICQHGEPECKGNMIQACILHLTTNSLAFQIIYCMESSADVLSAAQPCLHLYAPSVSWSSVNSCVSGDLGFRLMHGNAVMTRALNPPHTHVPWVTFNGEYTEENEEKAMSSLFHLVCELYQ 239

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Match: SMESG000052978.1 (SMESG000052978.1)

HSP 1 Score: 459.529 bits (1181), Expect = 9.576e-164
Identity = 223/224 (99.55%), Postives = 223/224 (99.55%), Query Frame = 1

Query:  514 MSLDSTTCCYKFCFNIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 1185
            MSL STTCCYKFCFNIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS
Sbjct:    1 MSLYSTTCCYKFCFNIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 224

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Match: SMESG000052978.1 (SMESG000052978.1)

HSP 1 Score: 431.409 bits (1108), Expect = 5.545e-153
Identity = 208/208 (100.00%), Postives = 208/208 (100.00%), Query Frame = 1

Query:  562 MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 1185
            MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS
Sbjct:    1 MSFTLLIFLISQAASGCFSTFQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 208

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Match: SMESG000052978.1 (SMESG000052978.1)

HSP 1 Score: 393.66 bits (1010), Expect = 6.668e-138
Identity = 188/188 (100.00%), Postives = 188/188 (100.00%), Query Frame = 1

Query:  622 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 1185
            FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS
Sbjct:   35 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 222

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Match: SMESG000052978.1 (SMESG000052978.1)

HSP 1 Score: 392.889 bits (1008), Expect = 1.179e-137
Identity = 188/188 (100.00%), Postives = 188/188 (100.00%), Query Frame = 1

Query:  622 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 1185
            FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS
Sbjct:   32 FQDADGDNKLVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSNQDKATTYLKGLICSYFKIRPPQCS 219

[Close]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Match: SMESG000046200.1 (SMESG000046200.1)

HSP 1 Score: 123.25 bits (308), Expect = 7.018e-33
Identity = 59/173 (34.10%), Postives = 99/173 (57.23%), Query Frame = 1

Query:  649 LVLDVYMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFNCQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEYNLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIIN----KVFSQSNQDKATTYLKGLICS 1155
            + LDV++E++CPD++ F+ +QL+P       F ++ ++P+GKA+  F N +W F CQ+G  EC GN I  CA ++T    Y+PF  C M NL+P+A++  C +++ +D   +N C E  +G  L +  A+ T    P + ++P ++ N      +S+      T  LKG I S
Sbjct:   32 MKLDVFIESKCPDSKKFLIEQLIPFYNKHKNFSSIRIFPFGKANVSFKNNRWNFVCQNGPMECAGNIIFGCAANMTTIDHYLPFIGCSMTNLSPVADYPYCAKKFKIDLAQLNNCAESYRGILLHYNNAMETRLYEP-IRFVPHLVFNGKSDPFYSRIIVSNITAVLKGSIPS 203

The following BLAST results are available for this feature:

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Human
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Zebrafish
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Xenopus
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Mouse
BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Cavefish
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Sea Lamprey
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Yeast
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Nematostella
BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Medaka
BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1


Match Name	E-value	Identity	Description
IFI30	1.883e-22	31.61	IFI30 lysosomal thiol reductase [Source:HGNC Symbo...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
C02D5.2	5.816e-23	32.97	GILT-like protein C02D5.2 [Source:UniProtKB/Swiss...	[more]
C02D5.2	1.671e-22	33.15	GILT-like protein C02D5.2 [Source:UniProtKB/Swiss...	[more]
F37H8.5	3.885e-16	29.59	GILT-like protein F37H8.5 [Source:UniProtKB/Swiss...	[more]
ZK669.2	2.450e-15	27.37	pep chromosome:WBcel235:II:7936592:7938583:-1 gene...	[more]
pqn-48	3.385e-13	29.66	Prion-like-(Q/N-rich)-domain-bearing protein [Sou...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG41378	3.590e-27	36.26	gene:FBgn0085638 transcript:FBtr0301791	[more]
CG41378	4.689e-27	36.26	gene:FBgn0085638 transcript:FBtr0301792	[more]
CG41378	1.165e-26	36.26	gene:FBgn0085638 transcript:FBtr0301790	[more]
CG9427	2.947e-22	34.07	gene:FBgn0037721 transcript:FBtr0082104	[more]
CG9427	6.640e-21	34.09	gene:FBgn0037721 transcript:FBtr0334619	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ifi30	7.600e-31	34.57	IFI30 lysosomal thiol reductase [Source:NCBI gene;...	[more]
ifi30	7.600e-31	34.57	IFI30 lysosomal thiol reductase [Source:NCBI gene;...	[more]
si:dkey-197i20.6	4.848e-28	33.33	si:dkey-197i20.6 [Source:ZFIN;Acc:ZDB-GENE-131127-...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nxpe3	1.043e-29	32.83	neurexophilin and PC-esterase domain family member...	[more]
nxpe3	1.642e-29	32.67	neurexophilin and PC-esterase domain family member...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Ifi30	3.371e-19	29.53	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
Ifi30	3.371e-19	29.53	Gamma-interferon-inducible lysosomal thiol reducta...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|E7E2N8\|GILT_CARAU	4.125e-30	36.52	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
sp\|Q5XJN2\|GILT_DANRE	5.737e-30	34.57	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
sp\|A6QPN6\|GILT_BOVIN	3.372e-24	32.39	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
sp\|B3SP85\|GILT_PIG	3.481e-22	28.93	Gamma-interferon-inducible-lysosomal thiol reducta...	[more]
sp\|P13284\|GILT_HUMAN	9.044e-22	31.61	Gamma-interferon-inducible lysosomal thiol reducta...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3G3LPG6	2.847e-102	69.38	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
A7SMR3	4.748e-36	34.74	Predicted protein OS=Nematostella vectensis OX=453...	[more]
A0A2P2I298	6.824e-36	40.00	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
A0A2B4SSD0	1.430e-35	36.82	Gamma-interferon-inducible lysosomal thiol reducta...	[more]
A7SMR2	3.643e-35	36.96	Predicted protein OS=Nematostella vectensis OX=453...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
si:dkey-197i20.6	2.209e-28	34.25	IFI30 lysosomal thiol reductase [Source:NCBI gene;...	[more]
ENSAMXT00000037267.1	7.598e-28	31.91	gamma-interferon-inducible lysosomal thiol reducta...	[more]
ENSAMXT00000042139.1	1.305e-27	31.79	gamma-interferon-inducible lysosomal thiol reducta...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
IFI30	3.962e-34	35.57	IFI30 lysosomal thiol reductase [Source:HGNC Symbo...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO35014	6.567e-40	34.74	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35033	5.038e-39	36.96	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41893	7.814e-20	27.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ifi30	1.248e-33	38.07	gamma-interferon-inducible lysosomal thiol reducta...	[more]
si:dkey-197i20.6	1.358e-30	33.33	IFI30 lysosomal thiol reductase [Source:NCBI gene;...	[more]
si:dkey-197i20.6	3.964e-28	33.14	IFI30 lysosomal thiol reductase [Source:NCBI gene;...	[more]

BLAST of IFI30 lysosomal thiol reductase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000052978.1	9.576e-164	99.55	SMESG000052978.1	[more]
SMESG000052978.1	5.545e-153	100.00	SMESG000052978.1	[more]
SMESG000052978.1	6.668e-138	100.00	SMESG000052978.1	[more]
SMESG000052978.1	1.179e-137	100.00	SMESG000052978.1	[more]
SMESG000046200.1	7.018e-33	34.10	SMESG000046200.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022650 ID=SMED30022650|Name=IFI30 lysosomal thiol reductase|organism=Schmidtea mediterranea sexual|type=transcript|length=1251bp
TGTCAAACAAACGGTTCTTTTTAATTTTAATATTTTCTCAAAAATGTTCA
CACTGTAATCTTAATGCAGGAATATTCAGTAATGACATGCGCCAGAACAG
CTATTAAACTGATATTAAATACATTGGGATCTATCCACATCCATCACATT
TATAAATAAGCAACAGTTTTGTGTGTCCTCGCATGAGATCTGCAAACTGC
CTGTTTATATTAGATTCAATTTGGAAATTTTTTAAATCAATTTTATGACA
ATGTAAAGTCCAAATCGCTCATAAAATTGATAGCATTTCACTGGCAGTTC
CACATTATTAATGATTTTGTTTATTCCATAGTTTTATCACTGTGCCGAGA
TTCAGAAAATCGTTGACCAAAGTTGCAATTGTGCAATCCATTGATAATTC
TGCAATTTTTATTGATTATTCTTACTGAGAACTAATTAATTGAGAGCTAA
CATTCATATATTTTGAAACTCAGTTGGAACATACCGGCACCAATTTGAAA
ATATTTGTGTGAAATGTCGCTAGATAGCACCACGTGTTGCTATAAATTTT
GTTTTAATATCATGAGTTTCACTTTGCTGATTTTCCTCATTTCTCAAGCA
GCTTCTGGATGCTTTTCCACGTTTCAGGATGCTGATGGAGACAACAAATT
GGTGCTTGATGTCTACATGGAGACTCGATGTCCTGATACGCAAGTTTTCA
TTGATGATCAATTAGTTCCAGTAACGCAACTGTTGGGAGGCTTTATCACC
GTCAATCTTTATCCTTATGGCAAAGCTGATGAGAAATTCGTTAATGGCAA
ATGGGAATTCAATTGCCAACATGGGTCACAGGAGTGTCAGGGAAACACAA
TTTTGGCCTGCGCCATATCTATAACTAACCAATCAACCTATGTGCCTTTT
TCATCTTGTTTAATGAAAAACTTGAACCCATTGGCCAATTTTAAAACATG
TTGCGAAGAATACAATTTAGATTACGATTTGATTAACGAATGCTTCGAAG
GGGATAAAGGCAATTCATTACAGCACAAATATGCTCTAGCTACCTCCAGT
TTGGTACCAAAACTAGCCTACATTCCATGGATTATTATTAATAAAGTATT
TTCTCAATCAAATCAAGATAAAGCTACGACGTATTTGAAAGGTCTCATTT
GCAGTTATTTCAAGATACGGCCTCCTCAGTGTTCCTGAAAATACAAATTC
ATTTTATAAAGAAAAATAATTTTTTGTAAAATTTGAACTAATAAATATAG
C

protein sequence of SMED30022650-orf-1

>SMED30022650-orf-1 ID=SMED30022650-orf-1|Name=SMED30022650-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=225bp
MSLDSTTCCYKFCFNIMSFTLLIFLISQAASGCFSTFQDADGDNKLVLDV
YMETRCPDTQVFIDDQLVPVTQLLGGFITVNLYPYGKADEKFVNGKWEFN
CQHGSQECQGNTILACAISITNQSTYVPFSSCLMKNLNPLANFKTCCEEY
NLDYDLINECFEGDKGNSLQHKYALATSSLVPKLAYIPWIIINKVFSQSN
QDKATTYLKGLICSYFKIRPPQCS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0047134	protein-disulfide reductase activity
GO:0016491	oxidoreductase activity
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000067	goblet cell
PLANA:0002075	pigment cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR004911	Interferon-induced_GILT

Vocabulary: **biological process**
Term	Definition
GO:0002376	immune system process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0055114	oxidation-reduction process

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region
GO:0005764	lysosome

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR004911	Gamma interferon inducible lysosomal thiol reductase GILT	PFAM	PF03227	GILT	coord: 48..149 e-value: 3.6E-27 score: 94.7
IPR004911	Gamma interferon inducible lysosomal thiol reductase GILT	PANTHER	PTHR13234	GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT	coord: 24..217
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..31 score: 0.717
None	No IPR available	TMHMM	TMhelix		coord: 12..31

Main menu

IFI30 lysosomal thiol reductase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Owlery

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