TM2 domain-containing protein 2

Overview
NameTM2 domain-containing protein 2
Smed IDSMED30022566
Length (bp)799
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TM2 domain-containing protein 2 (SMED30022566) t-SNE clustered cells

Violin plots show distribution of expression levels for TM2 domain-containing protein 2 (SMED30022566) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TM2 domain-containing protein 2 (SMED30022566) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TM2 domain-containing protein 2 (SMED30022566) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30022566

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30022566h1SMcG0011522 dd_Smed_v4_5982_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30022566h1SMcG0011522 dd_Smed_v4_5982_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30022566h1SMcG0011522 dd_Smed_v4_5982_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Match: TM2D2 (TM2 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24127])

HSP 1 Score: 156.762 bits (395), Expect = 9.033e-47
Identity = 87/151 (57.62%), Postives = 105/151 (69.54%), Query Frame = 3 
Query:  165 DVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            D  SP+I C+YLP  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   65 DPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 214
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Match: TM2D2 (TM2 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24127])

HSP 1 Score: 146.362 bits (368), Expect = 2.628e-43
Identity = 82/142 (57.75%), Postives = 98/142 (69.01%), Query Frame = 3 
Query:  192 NYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            NY P  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   31 NYRPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 171
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Match: TM2D2 (TM2 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24127])

HSP 1 Score: 146.362 bits (368), Expect = 2.628e-43
Identity = 82/142 (57.75%), Postives = 98/142 (69.01%), Query Frame = 3 
Query:  192 NYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            NY P  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   31 NYRPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 171
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Match: TM2D2 (TM2 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24127])

HSP 1 Score: 91.6633 bits (226), Expect = 7.912e-23
Identity = 46/89 (51.69%), Postives = 58/89 (65.17%), Query Frame = 3 
Query:  192 NYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLG 455
            NY P  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG
Sbjct:   31 NYRPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLG 118
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Match: TM2D3 (TM2 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24128])

HSP 1 Score: 60.077 bits (144), Expect = 2.079e-10
Identity = 35/91 (38.46%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C     + C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:   93 CTVRDHVHCLGNRTFPKMLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 182
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Celegans
Match: C02F5.13 (TM2 domain-containing protein C02F5.13 [Source:UniProtKB/Swiss-Prot;Acc:P61228])

HSP 1 Score: 138.272 bits (347), Expect = 3.959e-40
Identity = 78/158 (49.37%), Postives = 97/158 (61.39%), Query Frame = 3 
Query:  171 LSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFR--------GKVASEAV--TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            L P++ C +L  SFI CE+P+ LYG      Q        FR        G   +E V  T + C  L  IEC G RTF  ++ PCI ++GHYFL+TL+ SI LGV+ +DRF LG++  AVGK +TLGGFGIWWIVDI LL+ G L PAD S W PYY
Sbjct:   57 LGPVVECRFLENSFILCEDPVPLYGPGQTGQQPA---NESFRNEGKCLKMGGYRAEDVEFTNVKCRVLPCIECHGPRTF-TKSTPCIIYNGHYFLTTLLYSIFLGVVAVDRFCLGYSAMAVGKLMTLGGFGIWWIVDIFLLVLGVLGPADDSSWEPYY 210
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Celegans
Match: C41D11.9 (TM2 domain-containing protein C41D11.9 [Source:UniProtKB/Swiss-Prot;Acc:Q95QZ5])

HSP 1 Score: 71.2478 bits (173), Expect = 9.139e-15
Identity = 39/111 (35.14%), Postives = 60/111 (54.05%), Query Frame = 3 
Query:  273 YGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            Y C+       +S  +    C A   + C G R F+ +  PC   SG+ +  T+I S++LG  G DRF LG   +A+GK  + GG G+W +VD+VL+  G + P D S ++
Sbjct:   86 YDCEPATNCSTSSTKLLVTKCSAHSSVICMGQRNFY-KRIPCNWSSGYSWTKTMILSVVLGGFGADRFYLGLWKSAIGKLFSFGGLGVWTLVDVVLIAVGYIKPYDGSMYI 195
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Celegans
Match: Y66D12A.21 (TM2 domain-containing protein Y66D12A.21 [Source:UniProtKB/Swiss-Prot;Acc:Q95PJ8])

HSP 1 Score: 65.855 bits (159), Expect = 5.078e-13
Identity = 42/127 (33.07%), Postives = 67/127 (52.76%), Query Frame = 3 
Query:  273 YGCKNWFRGKVASEAVT-------KIVCHALKDIECSGNRTFFLENYPCIKFSGHY-----FLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPAD-HSYWMPYY 614
            Y CKN+    +  ++VT       +++C   + I+C G   F + N   +  + HY     + +T++ SI LG  GIDR  LG+    + K  +LGG  ++W+VDI+L+    L PAD  +Y M YY
Sbjct:   30 YLCKNYAVDTITQQSVTCAADNSIQVMCETAEHIKCVGKDQFGIFNRT-VPSACHYGAHVSYTTTVLLSIFLGFFGIDRIYLGYYALGLIKMFSLGGLFVFWLVDIILISLQLLGPADGTAYAMAYY 155
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Match: CG11103 (gene:FBgn0030522 transcript:FBtr0100218)

HSP 1 Score: 150.599 bits (379), Expect = 3.091e-45
Identity = 72/148 (48.65%), Postives = 97/148 (65.54%), Query Frame = 3 
Query:  171 LSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIV-CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPY 611
            L P + C++LP  F+ C++P+D   N T   +  YGC   F G    E    +V C    DIEC GNRTF     PC++++ HYF++TLI S+LLG +G+DRF LG TGTAVGK LT+GG G+WWI+D++LLI  +L+P D S W PY
Sbjct:   25 LGPNVMCSFLPRDFLDCKDPVDHRENATAQQEKKYGCLK-FGGSTYEEVEHAMVWCTVFADIECYGNRTFLRAGVPCVRYTDHYFVTTLIYSMLLGFLGMDRFCLGQTGTAVGKLLTMGGVGVWWIIDVILLITNNLLPEDGSNWNPY 171
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Match: CG10795 (gene:FBgn0034626 transcript:FBtr0071609)

HSP 1 Score: 69.3218 bits (168), Expect = 4.039e-14
Identity = 52/146 (35.62%), Postives = 73/146 (50.00%), Query Frame = 3 
Query:  183 IRCNYLPY-SFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHS-YWMPYY 614
            + CN L       C +P    G I    Q   GC    R +V   A  +I C        +GN TF  E  PC   +G++  +TL+ S+ LG+ G+DRF LG+ G  + K  TLGG  +  ++DIVL+    + PAD S Y +PYY
Sbjct:   21 VDCNELQMMGQFMCPDPA--RGQIDPKTQQLAGCTREGRARVWCIAANEINCTE------TGNATFTRE-VPCKWTNGYHLDTTLLLSVFLGMFGVDRFYLGYPGIGLLKFCTLGGMFLGQLIDIVLIALQVVGPADGSAYVIPYY 157
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Match: CG10795 (gene:FBgn0034626 transcript:FBtr0474124)

HSP 1 Score: 68.9366 bits (167), Expect = 9.482e-14
Identity = 49/135 (36.30%), Postives = 70/135 (51.85%), Query Frame = 3 
Query:  219 CEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECS--GNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHS-YWMPYY 614
            C +P    G I    Q   GC          E   ++ C A  +I C+  GN TF  E  PC   +G++  +TL+ S+ LG+ G+DRF LG+ G  + K  TLGG  +  ++DIVL+    + PAD S Y +PYY
Sbjct:   34 CPDPAR--GQIDPKTQQLAGC--------TREGRARVWCIAANEINCTETGNATFTRE-VPCKWTNGYHLDTTLLLSVFLGMFGVDRFYLGYPGIGLLKFCTLGGMFLGQLIDIVLIALQVVGPADGSAYVIPYY 157
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Match: amx (gene:FBgn0000077 transcript:FBtr0071331)

HSP 1 Score: 68.1662 bits (165), Expect = 4.231e-13
Identity = 36/100 (36.00%), Postives = 56/100 (56.00%), Query Frame = 3 
Query:  306 ASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            A++ + +  C    D+ C GNR+F   N  C    G+ + + L+ S+ LG  G DRF LGH    +GK  + GG G+W I+D++L+    L PAD S ++
Sbjct:  186 ATDKLFRTNCTVHHDVLCLGNRSF-TRNLRCNWTQGYRWSTALLISLTLGGFGADRFYLGHWQEGIGKLFSFGGLGVWTIIDVLLISMHYLGPADGSLYI 284
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Match: amx (gene:FBgn0000077 transcript:FBtr0307281)

HSP 1 Score: 68.1662 bits (165), Expect = 4.231e-13
Identity = 36/100 (36.00%), Postives = 56/100 (56.00%), Query Frame = 3 
Query:  306 ASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            A++ + +  C    D+ C GNR+F   N  C    G+ + + L+ S+ LG  G DRF LGH    +GK  + GG G+W I+D++L+    L PAD S ++
Sbjct:  186 ATDKLFRTNCTVHHDVLCLGNRSF-TRNLRCNWTQGYRWSTALLISLTLGGFGADRFYLGHWQEGIGKLFSFGGLGVWTIIDVLLISMHYLGPADGSLYI 284
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Zebrafish
Match: tm2d2 (TM2 domain containing 2 [Source:NCBI gene;Acc:436913])

HSP 1 Score: 155.992 bits (393), Expect = 1.989e-46
Identity = 86/176 (48.86%), Postives = 117/176 (66.48%), Query Frame = 3 
Query:   90 ENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            E    +S  +  T+  N +    EY+  SP++ C YLP  FI+C++P+D  GN++ + +LGYGC   F G+V  +   T+++C AL  IEC+G R F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G L P+D S W  +Y
Sbjct:   56 EENVTESGSVIPTETSNHTE-QYEYNPPSPVVLCRYLPEEFIFCQDPVDHGGNVSAFQELGYGCVK-FGGQVYKDVNHTQVLCTALDGIECAGPREFLRGNEPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLTPSDSSNWCTFY 229
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Zebrafish
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:100093711])

HSP 1 Score: 58.5362 bits (140), Expect = 1.044e-9
Identity = 33/88 (37.50%), Postives = 47/88 (53.41%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHS 596
            C  L+ + C G R F    + C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S
Sbjct:  155 CEVLEHVHCLGKRVFQKRLF-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGS 241
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Xenopus
Match: tm2d2 (TM2 domain containing 2 [Source:NCBI gene;Acc:496785])

HSP 1 Score: 154.451 bits (389), Expect = 4.674e-46
Identity = 84/171 (49.12%), Postives = 111/171 (64.91%), Query Frame = 3 
Query:  102 KKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
             ++S +   D+ N S   +  D L PL+ C+YLP  F+ C++P+D  GN T   +L YGCK +          T+++C AL  IEC G R+F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D+S W   Y
Sbjct:   29 NQTSPVTYPDL-NLSAAPEPRDPLGPLVLCSYLPEEFVECDDPVDHMGNGTAQQELRYGCKKFGGQAYGDVEHTQVMCRALDGIECDGPRSFLRGNKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDNSNWCTIY 198
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Xenopus
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:100145816])

HSP 1 Score: 60.8474 bits (146), Expect = 1.922e-10
Identity = 36/92 (39.13%), Postives = 48/92 (52.17%), Query Frame = 3 
Query:  330 VCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
             C  L    C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D+ L+  G + PAD S ++
Sbjct:  157 TCTVLDHAHCLGNRTFPKMLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVFLISVGYVGPADGSLYI 247
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Match: Tm2d2 (TM2 domain containing 2 [Source:MGI Symbol;Acc:MGI:1916992])

HSP 1 Score: 150.984 bits (380), Expect = 1.100e-44
Identity = 84/151 (55.63%), Postives = 104/151 (68.87%), Query Frame = 3 
Query:  165 DVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            D  SP+I C+YLP  F+ C+ P+D  GN T   +LGYGC   F G+  S+   T + C AL+ IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   64 DPNSPVILCSYLPDEFVDCDAPVDHVGNATASQELGYGCLK-FGGQAYSDVQHTAVQCRALEGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 213
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Match: Tm2d3 (TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI:1915884])

HSP 1 Score: 60.4622 bits (145), Expect = 2.616e-10
Identity = 36/91 (39.56%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C     I C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  163 CTVRDHIHCLGNRTFPKLLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 252
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Match: Tm2d3 (TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI:1915884])

HSP 1 Score: 60.077 bits (144), Expect = 2.849e-10
Identity = 36/91 (39.56%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C     I C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  141 CTVRDHIHCLGNRTFPKLLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 230
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Match: Tm2d3 (TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI:1915884])

HSP 1 Score: 60.077 bits (144), Expect = 2.886e-10
Identity = 36/91 (39.56%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C     I C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  172 CTVRDHIHCLGNRTFPKLLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 261
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Match: Tm2d3 (TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI:1915884])

HSP 1 Score: 60.077 bits (144), Expect = 2.886e-10
Identity = 36/91 (39.56%), Postives = 49/91 (53.85%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C     I C GNRTF    Y C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  172 CTVRDHIHCLGNRTFPKLLY-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 261
[Close]
BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q5XGR4|TM2D2_XENLA (TM2 domain-containing protein 2 OS=Xenopus laevis OX=8355 GN=tm2d2 PE=2 SV=1)

HSP 1 Score: 171.785 bits (434), Expect = 3.470e-52
Identity = 84/171 (49.12%), Postives = 110/171 (64.33%), Query Frame = 3 
Query:  102 KKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
              +S +   DI N S   +  D L PL+ C+YLP  F+ C++P+D  GN T   +L YGCK +          T+++C AL  IEC G+R+F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LT GG GIWW VD++LLI G LMP+D+S W   Y
Sbjct:   29 NNTSPVTYPDI-NVSAAPEPRDPLGPLVLCSYLPEEFVECDDPVDHMGNGTAQQELRYGCKKFGGQAYGDVEHTQVMCRALDGIECDGSRSFLRGNRPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTWGGLGIWWFVDLILLITGGLMPSDNSNWCTIY 198
[Close]
BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q5RCC0|TM2D2_PONAB (TM2 domain-containing protein 2 OS=Pongo abelii OX=9601 GN=TM2D2 PE=2 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 3.105e-46
Identity = 87/151 (57.62%), Postives = 105/151 (69.54%), Query Frame = 3 
Query:  165 DVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            D  SP+I C+YLP  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   65 DPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALAGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 214
[Close]
BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q9BX73|TM2D2_HUMAN (TM2 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TM2D2 PE=1 SV=1)

HSP 1 Score: 156.762 bits (395), Expect = 4.338e-46
Identity = 87/151 (57.62%), Postives = 105/151 (69.54%), Query Frame = 3 
Query:  165 DVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            D  SP+I C+YLP  FI CE+P+D  GN T   +LGYGC   F G+  S+   T + CHAL  IEC+  RTF  EN PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W   Y
Sbjct:   65 DPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLK-FGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY 214
[Close]
BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q6DHN3|TM2D2_DANRE (TM2 domain-containing protein 2 OS=Danio rerio OX=7955 GN=tm2d2 PE=2 SV=1)

HSP 1 Score: 155.992 bits (393), Expect = 1.502e-45
Identity = 86/176 (48.86%), Postives = 117/176 (66.48%), Query Frame = 3 
Query:   90 ENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAV-TKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            E    +S  +  T+  N +    EY+  SP++ C YLP  FI+C++P+D  GN++ + +LGYGC   F G+V  +   T+++C AL  IEC+G R F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G L P+D S W  +Y
Sbjct:   56 EENVTESGSVIPTETSNHTE-QYEYNPPSPVVLCRYLPEEFIFCQDPVDHGGNVSAFQELGYGCVK-FGGQVYKDVNHTQVLCTALDGIECAGPREFLRGNEPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLTPSDSSNWCTFY 229
[Close]
BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Match: sp|Q5M8E3|TM2D2_XENTR (TM2 domain-containing protein 2 OS=Xenopus tropicalis OX=8364 GN=tm2d2 PE=2 SV=1)

HSP 1 Score: 154.451 bits (389), Expect = 2.476e-45
Identity = 84/171 (49.12%), Postives = 111/171 (64.91%), Query Frame = 3 
Query:  102 KKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
             ++S +   D+ N S   +  D L PL+ C+YLP  F+ C++P+D  GN T   +L YGCK +          T+++C AL  IEC G R+F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D+S W   Y
Sbjct:   29 NQTSPVTYPDL-NLSAAPEPRDPLGPLVLCSYLPEEFVECDDPVDHMGNGTAQQELRYGCKKFGGQAYGDVEHTQVMCRALDGIECDGPRSFLRGNKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDNSNWCTIY 198
[Close]
BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Match: Q5D8H6 (TM2 domain-containing protein OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 199.519 bits (506), Expect = 1.603e-60
Identity = 99/181 (54.70%), Postives = 126/181 (69.61%), Query Frame = 3 
Query:   72 DIPILKENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            DIP++    FK S   N +++ ++S     YD LSPL++C+YLP   IWCE PLDL  N + Y++L YGC  W      S  +T +VCHAL +IEC GNRTF L +YPC+ F GHYF++T I S+LLG +G+DR  LGH GT +GK LTLGG GIWWIVDI+LLI G+L PAD S WMP+Y
Sbjct:   24 DIPVVDN--FKYSE--NNSELFDEST-GFSYDPLSPLVKCSYLPRHSIWCEPPLDLRSNKSLYDELKYGCLKWGGRASGSVMLTSLVCHALDNIECYGNRTFLLPDYPCLHFKGHYFVTTFIYSLLLGFLGVDRLCLGHIGTGIGKLLTLGGAGIWWIVDIILLIRGNLSPADGSSWMPFY 199
[Close]
BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Match: A0A4Z2DQR7 (TM2 domain-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_009807 PE=4 SV=1)

HSP 1 Score: 196.823 bits (499), Expect = 5.815e-60
Identity = 91/152 (59.87%), Postives = 111/152 (73.03%), Query Frame = 3 
Query:  159 EYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
             YD LSPL++C+YLP   IWCE PLDL  N + Y++L YGC  W      S  +T +VCHAL +IEC GNRTF L +YPC+ F GHYF++T I S+LLG +G+DR  LGH GT +GK LTLGG GIWWIVDI+LLI G+L PAD S WMP+Y
Sbjct:   15 SYDPLSPLVKCSYLPRHSIWCEPPLDLRSNKSLYDELKYGCLKWGGRASGSVMLTSLVCHALDNIECYGNRTFLLPDYPCLHFKGHYFVTTFIYSLLLGFLGVDRLCLGHIGTGIGKLLTLGGAGIWWIVDIILLIRGNLSPADGSSWMPFY 166
[Close]
BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Match: A0A3P6TU40 (TM2 domain-containing protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS2187 PE=4 SV=1)

HSP 1 Score: 194.512 bits (493), Expect = 1.561e-58
Identity = 99/182 (54.40%), Postives = 120/182 (65.93%), Query Frame = 3 
Query:   69 LDIPIL-KENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPY 611
             D+PIL KE PF      N T   N+S     YD  SPL+ C+YLP   IWCE P DL+GN + + +   GC  W   K     +T I CHAL DIEC GNRTF L +YPC+++ GHYFL+TL+ SI LG +G+DRF LGH GT VGK LT+GG G+WW+VDI LLI GDL PAD S WMP+
Sbjct:   21 FDVPILHKEPPFS-----NTTAFYNEST-GFVYDPNSPLVMCSYLPRHSIWCEPPEDLHGNKSLFLETNQGCYQWGGMKAEEVQLTSITCHALPDIECYGNRTFILHDYPCLRYHGHYFLTTLLYSIFLGFLGVDRFCLGHLGTGVGKLLTVGGCGVWWLVDIFLLIHGDLRPADDSSWMPF 196
[Close]
BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Match: A0A0X3Q8L3 (TM2 domain-containing protein 2 OS=Schistocephalus solidus OX=70667 GN=TM2D2 PE=4 SV=1)

HSP 1 Score: 191.815 bits (486), Expect = 1.581e-57
Identity = 98/182 (53.85%), Postives = 120/182 (65.93%), Query Frame = 3 
Query:   69 LDIPIL-KENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPY 611
             D+PIL KE PF      N T   N+S     YD  SPL+ C+YL    +WCE P DL+GN + + +   GC  W   KV    +T I CHAL DIEC GNRTF L +YPC+++ GHYFL+TL+ SI LG +G+DRF LGH GT VGK LT+GG G+WW+VDI LLI GDL PAD S WMP+
Sbjct:   21 FDVPILHKEPPFT-----NTTAFFNEST-GFVYDPNSPLVMCSYLSRHSMWCEPPEDLHGNKSLFLETTQGCYQWGGMKVDEVQLTSITCHALPDIECYGNRTFLLHDYPCLRYHGHYFLTTLLYSIFLGFLGVDRFCLGHLGTGVGKLLTVGGCGVWWLVDIFLLIHGDLRPADDSSWMPF 196
[Close]
BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Match: A0A0X3PZQ0 (TM2 domain-containing protein 2 OS=Schistocephalus solidus OX=70667 GN=TM2D2 PE=4 SV=1)

HSP 1 Score: 191.815 bits (486), Expect = 1.941e-57
Identity = 98/182 (53.85%), Postives = 120/182 (65.93%), Query Frame = 3 
Query:   69 LDIPIL-KENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPY 611
             D+PIL KE PF      N T   N+S     YD  SPL+ C+YL    +WCE P DL+GN + + +   GC  W   KV    +T I CHAL DIEC GNRTF L +YPC+++ GHYFL+TL+ SI LG +G+DRF LGH GT VGK LT+GG G+WW+VDI LLI GDL PAD S WMP+
Sbjct:   32 FDVPILHKEPPFT-----NTTAFFNEST-GFVYDPNSPLVMCSYLSRHSMWCEPPEDLHGNKSLFLETTQGCYQWGGMKVDEVQLTSITCHALPDIECYGNRTFLLHDYPCLRYHGHYFLTTLLYSIFLGFLGVDRFCLGHLGTGVGKLLTVGGCGVWWLVDIFLLIHGDLRPADDSSWMPF 207
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Cavefish
Match: tm2d2 (TM2 domain containing 2 [Source:NCBI gene;Acc:103028514])

HSP 1 Score: 145.206 bits (365), Expect = 4.718e-42
Identity = 81/154 (52.60%), Postives = 104/154 (67.53%), Query Frame = 3 
Query:  159 EYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGC-KNWFRGKVASEA-VTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            EY   SP++ C YLP  F++CEEP D  GN T ++++G GC K   +G+V  +   T + C AL  IEC+  R F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G L P+D S W  +Y
Sbjct:  101 EYSPPSPVVLCRYLPEEFVYCEEPEDHKGNTTAHSEMGRGCLKIGNQGQVYKDVNHTPVWCTALDGIECAAPREFLRGNEPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLTPSDGSNWCTFY 254
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Cavefish
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:103040447])

HSP 1 Score: 60.077 bits (144), Expect = 2.824e-10
Identity = 33/93 (35.48%), Postives = 48/93 (51.61%), Query Frame = 3 
Query:  327 IVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
              C  L  + C G R F    + C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  170 TTCKVLDHVNCLGKREFQKRLF-CNWTGGYKWSTALTLSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIAVGYVGPADGSLYI 261
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Cavefish
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:103040447])

HSP 1 Score: 59.6918 bits (143), Expect = 4.119e-10
Identity = 33/93 (35.48%), Postives = 48/93 (51.61%), Query Frame = 3 
Query:  327 IVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
              C  L  + C G R F  +   C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  173 TTCKVLDHVNCLGKREF-QKRLFCNWTGGYKWSTALTLSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIAVGYVGPADGSLYI 264
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Sea Lamprey
Match: tm2d2 (TM2 domain containing 2 [Source:NCBI gene;Acc:436913])

HSP 1 Score: 154.451 bits (389), Expect = 1.260e-46
Identity = 85/183 (46.45%), Postives = 113/183 (61.75%), Query Frame = 3 
Query:   84 LKENPFKKSSDINKTDIVNKSYFND------EYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            + E   +   D  + ++ +   F        +YD +SP + C++LP  F+ CEEP+D   N T  ++LGYGC  +          TK+VC AL  IEC G RTF   + PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D S W  +Y
Sbjct:   44 VAEESVEDQEDTMRAEVKDHEIFEGGETSGAQYDPMSPNVMCSFLPDEFVECEEPVDHNNNETALHELGYGCLKFGGHAYKDVNHTKVVCTALPKIECVGKRTFLRGHVPCIKYNGHYFVTTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDGSNWCTFY 226
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Sea Lamprey
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:100093711])

HSP 1 Score: 70.4774 bits (171), Expect = 4.780e-15
Identity = 45/132 (34.09%), Postives = 63/132 (47.73%), Query Frame = 3 
Query:  210 FIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            F W + P  LY      +    GC           A T+  C AL D+ C G RTF    Y C    GH + + L  S+ LG  G DRF LG     +GK  + GG G+W ++D++L+  G + PAD S ++
Sbjct:   81 FCW-QLPPSLYHCTNSTSCPSAGCP---------RARTRANCTALPDVHCLGERTFMKMLY-CDWTGGHKWATALTLSVTLGGFGADRFYLGQWREGLGKLFSFGGLGVWTLLDVLLIAIGYIGPADGSLYI 201
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Sea Lamprey
Match: tm2d1 (TM2 domain containing 1 [Source:NCBI gene;Acc:100093710])

HSP 1 Score: 52.7582 bits (125), Expect = 7.619e-9
Identity = 41/146 (28.08%), Postives = 63/146 (43.15%), Query Frame = 3 
Query:  186 RCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECS--GNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPAD-HSYWMPYY 614
            +C  L      C  P+     I    Q   GC N     V       + C   +  E +  G R  F +  PC   +G+++   +  S+ LG +G DRF LG+    + K  T+G  GI  ++D VL+    + P+D  SY + YY
Sbjct:   31 KCERLLLGQYICSSPI-----INDTTQEPVGCNNGTAPAVPCYPAPNVTCMDAQGKENTFDGERVGFTQLVPCRDTNGYHYTVAVAFSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFVLIAMQIVGPSDGSSYIIDYY 171
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Nematostella
Match: EDO38925 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH8])

HSP 1 Score: 153.68 bits (387), Expect = 1.700e-46
Identity = 84/170 (49.41%), Postives = 108/170 (63.53%), Query Frame = 3 
Query:  117 INKTDIVNKSYFNDE----YDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            +  T  ++   FN+     +D   PL+ C YLP  F+ CE+PLDL GN +   + GYGC  +   +      T++ C  L  IEC G R F     PCIK+SGHYF++TL+ SILLG +G+DRF LGHTGTAVGK LTLGG GIWW+VD++LL+ G L P D S W PYY
Sbjct:   26 VAYTGQLDSRCFNESCGRTFDPRGPLVDCQYLPLDFLDCEQPLDLKGNSSAKKEQGYGCVKFGGSRYDEVERTRVWCTVLDGIECYGERRFLGREVPCIKYSGHYFVTTLLYSILLGFLGVDRFCLGHTGTAVGKLLTLGGLGIWWVVDVILLVTGSLKPEDGSNWNPYY 195
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Nematostella
Match: EDO43932 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXA9])

HSP 1 Score: 67.0106 bits (162), Expect = 4.795e-14
Identity = 38/107 (35.51%), Postives = 59/107 (55.14%), Query Frame = 3 
Query:  306 ASEAVTKIVCHALKDIECSG---NRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHS-YWMPYY 614
            + +   +++CH +  + C     N T F    PC   +GH + + L+ SI LG+ GIDRF LG+    + K  TLG F I+ +VD++L+    + PAD S Y + YY
Sbjct:   20 SKDHTVEVMCHTVPGLTCESTETNSTEFKRKVPCRHTNGHSYENALLLSIFLGMFGIDRFYLGYPAIGLLKFCTLGFFFIFQLVDVLLIATQIVGPADGSDYVIDYY 126
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Nematostella
Match: EDO33613 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRN2])

HSP 1 Score: 55.0694 bits (131), Expect = 2.030e-9
Identity = 34/101 (33.66%), Postives = 55/101 (54.46%), Query Frame = 3 
Query:  333 CHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSIL----------LGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
            C   +++ C GNRTF  +   C   SG+ + + ++  ++          LG  GIDRF LGH    +GK  + GG G+W ++D+VL+  G + PAD S ++
Sbjct:   78 CTVKEEVLCLGNRTF-NKLLRCNWTSGYRWSTAVLLRLVDFNFFSLFLTLGGFGIDRFYLGHWKEGLGKLFSFGGLGVWTLIDLVLVGIGYIGPADGSLYI 177
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Medaka
Match: tm2d2 (TM2 domain containing 2 [Source:NCBI gene;Acc:101165152])

HSP 1 Score: 163.696 bits (413), Expect = 1.575e-49
Identity = 85/176 (48.30%), Postives = 116/176 (65.91%), Query Frame = 3 
Query:   96 PFKKSSDINKTDIVNKSYFNDE---YDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            PF +  ++ KT+   +S  + E   Y   SP++ C YLP  FI+C++P+D  GN + + ++ +GC  W          T+++C AL DIEC+G R F   N PCIK++GHYF++TL+ S  LG  G+DRF LGHTGTAVGK LTLGG GIWW VD++LLI G LMP+D+S W  YY
Sbjct:   55 PFTEQPEVGKTEGWTESVNSTELYEYRPPSPVVLCQYLPEEFIYCQDPVDHAGNYSAFQEMDHGCVGWGGQTEKEVNHTRVICTALDDIECAGPREFLRGNVPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLMPSDYSNWCTYY 230
[Close]
BLAST of TM2 domain-containing protein 2 vs. Ensembl Medaka
Match: tm2d3 (TM2 domain containing 3 [Source:NCBI gene;Acc:101166951])

HSP 1 Score: 58.9214 bits (141), Expect = 7.012e-10
Identity = 33/92 (35.87%), Postives = 49/92 (53.26%), Query Frame = 3 
Query:  330 VCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWM 605
             C  L+ + C G R F    + C    G+ + + L  SI LG  G DRF LG     +GK  + GG GIW ++D++L+  G + PAD S ++
Sbjct:  171 TCDVLEHVHCLGRRRFQKRLF-CNWTGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGPADGSLYI 261
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BLAST of TM2 domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000063274.1 (SMESG000063274.1)

HSP 1 Score: 379.022 bits (972), Expect = 6.300e-135
Identity = 200/201 (99.50%), Postives = 200/201 (99.50%), Query Frame = 3 
Query:   12 MFRKSXXXXXXXXXXXXXXLDIPILKENPFKKSSDINKTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 614
            MFRKSILIFNIIFVINCNFLDIPILKENPFKKSSDIN TDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY
Sbjct:    1 MFRKSILIFNIIFVINCNFLDIPILKENPFKKSSDINTTDIVNKSYFNDEYDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVASEAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPYY 201
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BLAST of TM2 domain-containing protein 2 vs. Planmine SMEST
Match: SMESG000074297.1 (SMESG000074297.1)

HSP 1 Score: 50.0618 bits (118), Expect = 3.419e-8
Identity = 27/68 (39.71%), Postives = 35/68 (51.47%), Query Frame = 3 
Query:  393 PCIKFSGHYFLSTLICSILLGVMGIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHS 596
            PC    G  +L+    S+  G  G DRF LG     +GK  T GG G+W  VD +L+  G L P+D S
Sbjct:    3 PCNWTEGKSWLTAFGLSLFFGGFGADRFYLGMWQMGLGKLFTFGGLGVWTFVDWILIAFGYLKPSDGS 70
The following BLAST results are available for this feature:
BLAST of TM2 domain-containing protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TM2D29.033e-4757.62TM2 domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TM2D22.628e-4357.75TM2 domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TM2D22.628e-4357.75TM2 domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TM2D27.912e-2351.69TM2 domain containing 2 [Source:HGNC Symbol;Acc:HG... [more]
TM2D32.079e-1038.46TM2 domain containing 3 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
C02F5.133.959e-4049.37TM2 domain-containing protein C02F5.13 [Source:Un... [more]
C41D11.99.139e-1535.14TM2 domain-containing protein C41D11.9 [Source:Un... [more]
Y66D12A.215.078e-1333.07TM2 domain-containing protein Y66D12A.21 [Source:... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG111033.091e-4548.65gene:FBgn0030522 transcript:FBtr0100218[more]
CG107954.039e-1435.62gene:FBgn0034626 transcript:FBtr0071609[more]
CG107959.482e-1436.30gene:FBgn0034626 transcript:FBtr0474124[more]
amx4.231e-1336.00gene:FBgn0000077 transcript:FBtr0071331[more]
amx4.231e-1336.00gene:FBgn0000077 transcript:FBtr0307281[more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tm2d21.989e-4648.86TM2 domain containing 2 [Source:NCBI gene;Acc:4369... [more]
tm2d31.044e-937.50TM2 domain containing 3 [Source:NCBI gene;Acc:1000... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tm2d24.674e-4649.12TM2 domain containing 2 [Source:NCBI gene;Acc:4967... [more]
tm2d31.922e-1039.13TM2 domain containing 3 [Source:NCBI gene;Acc:1001... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tm2d21.100e-4455.63TM2 domain containing 2 [Source:MGI Symbol;Acc:MGI... [more]
Tm2d32.616e-1039.56TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI... [more]
Tm2d32.849e-1039.56TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI... [more]
Tm2d32.886e-1039.56TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI... [more]
Tm2d32.886e-1039.56TM2 domain containing 3 [Source:MGI Symbol;Acc:MGI... [more]
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BLAST of TM2 domain-containing protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5XGR4|TM2D2_XENLA3.470e-5249.12TM2 domain-containing protein 2 OS=Xenopus laevis ... [more]
sp|Q5RCC0|TM2D2_PONAB3.105e-4657.62TM2 domain-containing protein 2 OS=Pongo abelii OX... [more]
sp|Q9BX73|TM2D2_HUMAN4.338e-4657.62TM2 domain-containing protein 2 OS=Homo sapiens OX... [more]
sp|Q6DHN3|TM2D2_DANRE1.502e-4548.86TM2 domain-containing protein 2 OS=Danio rerio OX=... [more]
sp|Q5M8E3|TM2D2_XENTR2.476e-4549.12TM2 domain-containing protein 2 OS=Xenopus tropica... [more]
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BLAST of TM2 domain-containing protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q5D8H61.603e-6054.70TM2 domain-containing protein OS=Schistosoma japon... [more]
A0A4Z2DQR75.815e-6059.87TM2 domain-containing protein OS=Schistosoma japon... [more]
A0A3P6TU401.561e-5854.40TM2 domain-containing protein OS=Dibothriocephalus... [more]
A0A0X3Q8L31.581e-5753.85TM2 domain-containing protein 2 OS=Schistocephalus... [more]
A0A0X3PZQ01.941e-5753.85TM2 domain-containing protein 2 OS=Schistocephalus... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tm2d24.718e-4252.60TM2 domain containing 2 [Source:NCBI gene;Acc:1030... [more]
tm2d32.824e-1035.48TM2 domain containing 3 [Source:NCBI gene;Acc:1030... [more]
tm2d34.119e-1035.48TM2 domain containing 3 [Source:NCBI gene;Acc:1030... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
tm2d21.260e-4646.45TM2 domain containing 2 [Source:NCBI gene;Acc:4369... [more]
tm2d34.780e-1534.09TM2 domain containing 3 [Source:NCBI gene;Acc:1000... [more]
tm2d17.619e-928.08TM2 domain containing 1 [Source:NCBI gene;Acc:1000... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO389251.700e-4649.41Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO439324.795e-1435.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO336132.030e-933.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TM2 domain-containing protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
tm2d21.575e-4948.30TM2 domain containing 2 [Source:NCBI gene;Acc:1011... [more]
tm2d37.012e-1035.87TM2 domain containing 3 [Source:NCBI gene;Acc:1011... [more]
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BLAST of TM2 domain-containing protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000063274.16.300e-13599.50SMESG000063274.1[more]
SMESG000074297.13.419e-839.71SMESG000074297.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30022566 ID=SMED30022566|Name=TM2 domain-containing protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=799bp
AAATGGTATAAATGTTTCGAAAATCAATTTTAATATTTAATATAATTTTC
GTAATAAATTGTAACTTTCTTGATATTCCTATATTAAAGGAAAATCCTTT
CAAAAAATCATCAGATATTAACAAAACAGATATTGTTAACAAAAGTTATT
TTAATGATGAATATGACGTATTGAGCCCATTAATTAGATGTAACTATCTA
CCATATAGTTTTATTTGGTGTGAAGAACCTTTGGATTTATATGGAAATAT
TACTAAATATAATCAACTTGGATATGGCTGTAAGAATTGGTTCAGAGGAA
AAGTCGCAAGCGAAGCAGTAACTAAAATTGTGTGTCACGCTCTTAAAGAT
ATAGAATGCAGTGGAAATAGGACTTTTTTTTTGGAAAATTATCCTTGCAT
AAAATTTTCTGGTCATTATTTTTTATCAACACTAATATGTTCAATTTTGC
TTGGAGTTATGGGAATAGATAGATTCATTTTGGGCCATACGGGAACGGCT
GTTGGAAAGGCTTTAACTTTGGGGGGATTTGGCATTTGGTGGATAGTGGA
CATCGTCTTGTTGATCGAAGGGGATTTAATGCCAGCAGATCACAGCTATT
GGATGCCATATTATTAAAAAAAGAATTATTTTCAGTTGCTTTTAGTAATT
TATTTTAATTATAATATGAAAACTGAATATTTGAAAGTTGAATATAAAAG
TTTAGAGTTGAATTAACTTTGTTAAATTATGAAATTAAATTTCAAAATTA
AGCATTTTTTTTGCTAATTATGTGAAAGGATTTGATGTGTATATTTATG
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protein sequence of SMED30022566-orf-1

>SMED30022566-orf-1 ID=SMED30022566-orf-1|Name=SMED30022566-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=202bp
MFRKSILIFNIIFVINCNFLDIPILKENPFKKSSDINKTDIVNKSYFNDE
YDVLSPLIRCNYLPYSFIWCEEPLDLYGNITKYNQLGYGCKNWFRGKVAS
EAVTKIVCHALKDIECSGNRTFFLENYPCIKFSGHYFLSTLICSILLGVM
GIDRFILGHTGTAVGKALTLGGFGIWWIVDIVLLIEGDLMPADHSYWMPY
Y*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002056medial muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR007829TM2
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane