Protein kinase domain-containing protein

Overview


Name	Protein kinase domain-containing protein
Smed ID	SMED30022545
Length (bp)	1948

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein kinase domain-containing protein (SMED30022545) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30022545) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30022545) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30022545) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022545

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30022545	SMESG000057044.1	dd_Smed_v6_9098_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
epidermis	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal region of the epidermis	SMED30022545	SMESG000057044.1	dd_Smed_v4_9098_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK11 (NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGNC:18593])

HSP 1 Score: 308.916 bits (790), Expect = 1.174e-97
Identity = 153/360 (42.50%), Postives = 232/360 (64.44%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

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Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK11 (NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGNC:18593])

HSP 1 Score: 308.531 bits (789), Expect = 2.845e-97
Identity = 153/360 (42.50%), Postives = 232/360 (64.44%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

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BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK11 (NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGNC:18593])

HSP 1 Score: 308.531 bits (789), Expect = 6.311e-96
Identity = 153/360 (42.50%), Postives = 232/360 (64.44%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: NEK11 (NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGNC:18593])

HSP 1 Score: 309.301 bits (791), Expect = 1.039e-95
Identity = 153/360 (42.50%), Postives = 232/360 (64.44%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nekl-3 (Serine/threonine-protein kinase nekl-3 [Source:UniProtKB/Swiss-Prot;Acc:G5EFM9])

HSP 1 Score: 174.096 bits (440), Expect = 3.845e-49
Identity = 93/263 (35.36%), Postives = 153/263 (58.17%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKV-LKEVNV-DTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGD--NLMRVMVTILESPCPRIPSN-YSENLQEVLECILVKDPDNRPKACEILDL 909
            +I    IGKG F  V     FR       + V LK++ V + +DQ   ++C +E  LL +LNH N+++++ SF   N   I+ E  E GD+ ++I+  K+ G  + E  I ++F+Q+   L ++H ++I+HRD+KP N+F+  +  VK+GD G+ R  +     A + +GTPYYMSPE ++  GYN  SD+WS+G +LYEM AL+  F GD  NL  +   I     P +P++ YS  L++++   ++ +   RP+  E+L +
Sbjct:   23 FIIEKKIGKGQFSEV-----FRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQLRDLVSRCILPEASKRPETSEVLQV 280

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Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKV-LKEVNV-DTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGD--NLMRVMVTILESPCPRIPSN-YSENLQEVLECILVKDPDNRPKACEILDL 909
            +I    IGKG F  V     FR       + V LK++ V + +DQ   ++C +E  LL +LNH N+++++ SF   N   I+ E  E GD+ ++I+  K+ G  + E  I ++F+Q+   L ++H ++I+HRD+KP N+F+  +  VK+GD G+ R  +     A + +GTPYYMSPE ++  GYN  SD+WS+G +LYEM AL+  F GD  NL  +   I     P +P++ YS  L++++   ++ +   RP+  E+L +
Sbjct:   23 FIIEKKIGKGQFSEV-----FRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQLRDLVSRCILPEASKRPETSEVLQV 280

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nekl-1 (NEK (NEver in mitosis Kinase) Like [Source:UniProtKB/TrEMBL;Acc:A0A061AD48])

HSP 1 Score: 185.267 bits (469), Expect = 4.346e-49
Identity = 105/265 (39.62%), Postives = 156/265 (58.87%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGT--VYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLAS---TFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDL 909
            NRY  +  +GKG+FG+  +Y+ ++        S+ ++KE+N+  +D  Q      E  LLS++ H NI+ ++DSF  E    I  EY +GG L Q++ +T+   + L+E +I    IQ+   + Y+H+  +LHRDLK  N+FL  DS VKIGDFGIS+I+  T  LA    T +GTPYY+SPE+     YN  SD+W+ G ILYEMC LK AF GDNL  ++ +I+      +   YS  ++ V+  +L  DP  RP A + L +
Sbjct:  131 NRYERIRTVGKGAFGSAVLYRRRE------DSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQ---NLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMG-TETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALKM 385

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nekl-1 (NEK (NEver in mitosis Kinase) Like [Source:UniProtKB/TrEMBL;Acc:A0A061AD48])

HSP 1 Score: 184.882 bits (468), Expect = 5.599e-49
Identity = 105/265 (39.62%), Postives = 156/265 (58.87%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGT--VYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLAS---TFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDL 909
            NRY  +  +GKG+FG+  +Y+ ++        S+ ++KE+N+  +D  Q      E  LLS++ H NI+ ++DSF  E    I  EY +GG L Q++ +T+   + L+E +I    IQ+   + Y+H+  +LHRDLK  N+FL  DS VKIGDFGIS+I+  T  LA    T +GTPYY+SPE+     YN  SD+W+ G ILYEMC LK AF GDNL  ++ +I+      +   YS  ++ V+  +L  DP  RP A + L +
Sbjct:  169 NRYERIRTVGKGAFGSAVLYRRRE------DSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQ---NLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMG-TETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALKM 423

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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: nekl-2 (Serine/threonine-protein kinase nekl-2 [Source:UniProtKB/Swiss-Prot;Acc:O01775])

HSP 1 Score: 154.066 bits (388), Expect = 2.747e-41
Identity = 85/261 (32.57%), Postives = 145/261 (55.56%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIE-----KTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL--KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFI 918
            +G+G+FG  +  +       Q+ I  +K +N   M + +      E  LL K+ H  I+ + DSF ++N   I+ +Y EGG L+++I      K      +  E  ++ +F Q++  L+++H++ I+HRDLKP NI +  +   +K+ DFGIS+ L  T   AST +GTP Y+SPE+ +   YN  SD+WS G +LYE+  L+ AF G+NL  +++ I  S    +  + S +++ ++E +L    D RP   ++L  P +
Sbjct:   10 VGRGAFGVCWLCRGKNDASHQKVI--IKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELG-TKSAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV 267

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Nek2 (gene:FBgn0029970 transcript:FBtr0071142)

HSP 1 Score: 184.111 bits (466), Expect = 2.881e-49
Identity = 96/267 (35.96%), Postives = 149/267 (55.81%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSF--RLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKR----KILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFI 918
            Y  L+ +G GSFGT YKV+D    +    +   K +N D +D+ + +    E  +L +L H NIV+++     R   +  I+ E C GGDL Q++++ +      EE  I R   Q+   L   H +     ILHRD+KP NIFL    + K+GDFG++R+L      A++F+GTP+YMSPE++K   Y+  SD+W+ G ++YEMCAL+  F G    ++   I +    RIP+ YS +LQE++  +L  D + RP    I+  P +
Sbjct:   19 YEVLAVMGNGSFGTCYKVRD----KSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLV 281

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: niki (gene:FBgn0045980 transcript:FBtr0084737)

HSP 1 Score: 169.088 bits (427), Expect = 9.338e-44
Identity = 97/250 (38.80%), Postives = 139/250 (55.60%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEIL 903
            +G+GSFG     +  R  +G +   V K++N+  +     +    E  + SKL+H NIV +  SF  +N   I  EY +GG L Q+I + ++   H  E  II  F Q+   ++Y+H   ILHRDLK  N+FL +   VKIGDFGIS+I+N T   A T LGTPYY SPE+ +   Y+  SDIW+ G IL EMC LK  F   NL  ++  I+      +PS Y+  L+ ++  +L  +   RP A E+L
Sbjct:  111 VGQGSFGIAILYR--RKSDGHQ--IVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAE-RQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMN-TKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: GckIII (gene:FBgn0266465 transcript:FBtr0083399)

HSP 1 Score: 158.688 bits (400), Expect = 6.890e-41
Identity = 91/269 (33.83%), Postives = 158/269 (58.74%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPW-IDIVE 957
            IGKGSFG V+K  D R     + +  +K ++++  + D+I++  +E  +LS+ +   + K++ SF       II EY  GG    ++    ++GS  EE+ I     +V++GLDY+H  + LHRD+K  N+ L +   VK+ DFG++  L  T    +TF+GTP++M+PEV+K   Y+  +DIWS G+   E+   +      + MRV+  I ++  P++  +Y+++ ++ +E  L KDP+NRP A E+L  PFIK   ++ + ID+++
Sbjct:   19 IGKGSFGEVFKGIDNR----TQQVVAIKIIDLEEAE-DEIDDIQQEIMVLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLM----KAGS-FEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFIKKAKKNAYLIDLID 277

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0290019)

HSP 1 Score: 144.821 bits (364), Expect = 1.772e-35
Identity = 82/266 (30.83%), Postives = 147/266 (55.26%), Query Frame = 1

Query:  145 FLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVL-----KHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRI--PSNYSENLQEVLECILVKDPDNRPKACEILDLPFI 918
             +  +G G+FG VYK +     + Q+     K   ++  D++ + +   E  +LS++ H NIV+ +++F +++   ++ EYC+GG L  ++ + ++    L E +I      + EGL ++H+ K++HRDLK  N+ L  +  VK+ DFG+S     T     TF+GTPY+M+PE++     + + Y+   DIWS G+ L E+  ++      + MRV++ I +S  P++  PS +S+   + L+  LVKDP  RP    ++   FI
Sbjct:   39 MVGELGDGAFGKVYKAQH----KEQKRFAAAKMCQLE--DEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKP---LTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI 295

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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Slik (gene:FBgn0035001 transcript:FBtr0100470)

HSP 1 Score: 144.436 bits (363), Expect = 1.916e-35
Identity = 82/266 (30.83%), Postives = 147/266 (55.26%), Query Frame = 1

Query:  145 FLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVL-----KHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRI--PSNYSENLQEVLECILVKDPDNRPKACEILDLPFI 918
             +  +G G+FG VYK +     + Q+     K   ++  D++ + +   E  +LS++ H NIV+ +++F +++   ++ EYC+GG L  ++ + ++    L E +I      + EGL ++H+ K++HRDLK  N+ L  +  VK+ DFG+S     T     TF+GTPY+M+PE++     + + Y+   DIWS G+ L E+  ++      + MRV++ I +S  P++  PS +S+   + L+  LVKDP  RP    ++   FI
Sbjct:   39 MVGELGDGAFGKVYKAQH----KEQKRFAAAKMCQLE--DEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKP---LTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI 295

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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek11 (NIMA-related kinase 11 [Source:ZFIN;Acc:ZDB-GENE-100922-73])

HSP 1 Score: 278.87 bits (712), Expect = 9.042e-85
Identity = 146/350 (41.71%), Postives = 214/350 (61.14%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRD--PWIDIVENDDMSETLVNNE--SKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSN 1161
             NRYI    +GKGSFGTVY VKD +    +E +KVLKE+ V  +  ++    T+E +LLS+L+H  I+KF+ SF   + +CIITE+CE  DL   +E+ K +G  L E ++  W  Q++ G+ YIH+R+ILHRDLK  NIFL+ + VKIGDFG+S  L  + DLA+TF GTPYYMSPE L H GY++ SDIWS G ILYEMC L HAF   N + V++ I+E P P +P  YS  L  +++ +L KD  +R  A + L   FI+  ++       I+   D S   +  E  +  I   L K   L  +   S   +++P++++ L+K   AD+KA + ++ +E+ ++ N
Sbjct:   28 ANRYIIQQRLGKGSFGTVYLVKDTKAV-AEERLKVLKEIPVGDLKPNETVHATQEAQLLSQLSHPAILKFYSSFLERDAFCIITEFCEDKDLDCKLEELKHTGKTLSEPQVCEWLCQLLLGVHYIHQRRILHRDLKAKNIFLRKNIVKIGDFGVSCFLMGSCDLATTFTGTPYYMSPEALSHKGYDSKSDIWSLGCILYEMCCLAHAFEAQNFLAVVLRIVEGPTPSLPETYSRQLNSLMQSMLEKDSSHRISAADALRNRFIEESLQSMKHKFSILSLRDKS---IGGERDASQILRALQKKVHLQTLQDRSEVQKMSPRERMRLRKLQAADEKARKLKQIVEEKYQEN 373

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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek1 (NIMA-related kinase 1 [Source:ZFIN;Acc:ZDB-GENE-040730-1])

HSP 1 Score: 213.001 bits (541), Expect = 1.079e-63
Identity = 109/267 (40.82%), Postives = 167/267 (62.55%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            ++Y  L  IG+GSFG    VK     +G++   V+KE+ +  M   + +E  +E  +L+ ++H NIV++ +SF       I+ +YCEGGDL + I   +  GS   E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P  RP    ILD PF+  +I
Sbjct:    2 DKYERLKKIGEGSFGKAILVKS--RTDGRQY--VIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEESGCLYIVMDYCEGGDLFKKINNQR--GSLFPEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSIHYSPDLRSLLAQLFKRNPRERPSVSTILDKPFLARRI 262

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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek4 (NIMA-related kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040426-1392])

HSP 1 Score: 216.853 bits (551), Expect = 3.113e-60
Identity = 107/266 (40.23%), Postives = 166/266 (62.41%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLEN-NYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            Y+F+  +GKGS+G V  V+     +      V+K++N+ T  + +     +E +LLS+L H NIV + +S+  E+    I+  +CEGGDL   +++ K  G  L E +++ WF+Q+   L Y+H++ ILHRDLK  NIFL K + +K+GD GI+R+L   ND+AST +GTPYYMSPE+  +  YN  SD+W+ G  +YEM  LKHAF   ++  ++  I+E   P++PS Y   L E+++ +L K P++RP    IL  P+IK +I
Sbjct:    4 YLFVRVVGKGSYGEVNLVRH----KSDRKQYVIKKLNLRTSSRRERRAAEQEAQLLSQLKHPNIVMYRESWEGEDCQLYIVMGFCEGGDLYHRLKQQK--GELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIVEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQPYIKHQI 263

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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek4 (NIMA-related kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040426-1392])

HSP 1 Score: 217.238 bits (552), Expect = 3.146e-60
Identity = 107/266 (40.23%), Postives = 166/266 (62.41%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLEN-NYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            Y+F+  +GKGS+G V  V+     +      V+K++N+ T  + +     +E +LLS+L H NIV + +S+  E+    I+  +CEGGDL   +++ K  G  L E +++ WF+Q+   L Y+H++ ILHRDLK  NIFL K + +K+GD GI+R+L   ND+AST +GTPYYMSPE+  +  YN  SD+W+ G  +YEM  LKHAF   ++  ++  I+E   P++PS Y   L E+++ +L K P++RP    IL  P+IK +I
Sbjct:    4 YLFVRVVGKGSYGEVNLVRH----KSDRKQYVIKKLNLRTSSRRERRAAEQEAQLLSQLKHPNIVMYRESWEGEDCQLYIVMGFCEGGDLYHRLKQQK--GELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIVEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQPYIKHQI 263

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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: nek12 (NIMA-related kinase 12 [Source:ZFIN;Acc:ZDB-GENE-050410-11])

HSP 1 Score: 196.823 bits (499), Expect = 2.315e-55
Identity = 105/285 (36.84%), Postives = 170/285 (59.65%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECT-REGKLLSKLNHSNIVKFFDSFRLENNYCI--ITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESK 999
            +G+G  G V  +K        + +  +K ++VD+  + + ++   +E  +L  L H +I+ + D+F    N  I  + +YC+GG L   I K ++ G H  E  I+ WF+QV+  + YIH  KILHRD+KP+N+ L K   +K+GDFGIS+I+N T D+AST +GTP Y+SPE+ +   Y+T SDIW+ G +LYE+CALK AF   NL+ +   I++    ++P  YSE++  ++E +L   P+NRP A  IL + +++  +     + + N +   T VN ES+
Sbjct:   10 LGQGGAGVVSLMKHV----DTKKLCAVKRIHVDSSRKTKTKDVVLQEAIVLRSLKHPHIITWIDTFFDATNESIYIVMDYCDGGTLDDHI-KEQKCGEHFTESNIMDWFVQVVMAVSYIHSEKILHRDIKPSNVLLTKRGVIKLGDFGISKIMNHTLDMASTCVGTPSYLSPELCQDVPYSTKSDIWAVGCLLYELCALKPAFQAKNLLSLFYKIIKGEYIKVPEMYSEDIHTLIEKMLSLIPENRPSAASILSMTYVQEHLG----NFITNQEKELTKVNAESR 285

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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: sult1c1 (sulfotransferase family, cytosolic, 1C, member 1 [Source:Xenbase;Acc:XB-GENE-6460751])

HSP 1 Score: 306.22 bits (783), Expect = 5.557e-95
Identity = 156/361 (43.21%), Postives = 233/361 (64.54%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDI--VENDDMSETLVNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +GKGSFGTVY V D +  + QES+KVLKE+ V  ++ ++  +   E +LLSKL+H  IVKF  SF    ++CIITEYCEG DL   + + K++   + E +++ WFIQ++ G++Y+H R+ILHRDLK  NIFLK + +KIGDFG+SR+L  + DLA+TF GTPYYMSPE LKH GY++ SDIWS G IL+EMC L+HAFIG N + V+++I+E   P +P  YS +L  ++  +L KDP  RP A EIL  PFI  +++    ++   E  D + T+   E+  I N + +   L  +   S   ++TP++++ L+K   AD+KA   ++  E+ ++ N +  ++L+   FQ
Sbjct:   25 AKRYLLQQRLGKGSFGTVYLVIDKKAKDEQESLKVLKEIPVGELNPNETVQANVEAQLLSKLDHPAIVKFHASFLENESFCIITEYCEGRDLDFKVRECKKNEEKIAENQVVEWFIQLLLGVNYMHVRRILHRDLKAKNIFLKNNLLKIGDFGVSRLLMGSCDLATTFTGTPYYMSPEALKHQGYDSKSDIWSLGCILHEMCCLEHAFIGYNFLSVVISIVEGETPSLPDCYSSSLNLIMNRMLNKDPALRPSAGEILQDPFINEQLKQVKWEVYGAEVKDKT-TICKKEADQIRNVVQRKFHLQTLRELSEVQKMTPRERMRLRKLNAADEKARRLKQLAEEKYQENHKRMQELRSRNFQ 384

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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000013864.1 (serine/threonine-protein kinase Nek11-like [Source:NCBI gene;Acc:100486125])

HSP 1 Score: 279.641 bits (714), Expect = 1.454e-85
Identity = 156/391 (39.90%), Postives = 225/391 (57.54%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFI--KSKIRDPWIDIVENDDMSETLVNNESKDISNF-LSKSTGLNI----ITAASVELTPKQKILLKKS------MEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSSLPFTNQRNASTRSSISEYDE 1266
             RY     +G GSF T Y V D +    Q   KVLK +  + M  D      RE KLL  L H  IV+F  SF  + ++CIITE+CEGGDL+  I+K +       E  +I WFIQ++ G++Y+H+R ILHRDLK  NIFLK  +VKIGDFG+SRIL+  +D+A+TF GTP+YMSPEVL+H GYN  SDIWS G ILYE+CAL+HA+   N ++++  I+E PCP +PS YS  L ++L+ +L KDP  RP A EIL +P +    K+   W+     + + E   +  S+D +   +     L++    I     E+ P+Q+  ++K       M+  K+A + R Y E   KS    R ++  D+ ++     +    S + S S+ +E
Sbjct:   27 GRYNIHHTLGSGSFATAYLVTDAKDAGHQ---KVLKRIPCEGMKPDATLPSAREAKLLGSLRHPFIVRFLSSFLEKEDFCIITEFCEGGDLQNRIQKQREKSQLFPEEHVIEWFIQLLLGVNYLHERLILHRDLKSKNIFLKNGTVKIGDFGVSRILSMPSDMATTFTGTPHYMSPEVLEHYGYNAKSDIWSLGCILYEICALRHAYDSANWIKLVSQIVEGPCPSLPSQYSAELNDILKRVLNKDPQQRPSASEILHMPTVVDHEKVLSIWL----QEALHEGRQDCGSEDAARIAVEMQEKLHVDSLRIMRQVQEMAPRQRRRIRKEEQQETHMKKIKRAVD-RLYKEMHPKSGQNRRSEINGDEDETPADVIHISEGSCKDSCSDSEE 409

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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: sez6l2 (seizure related 6 homolog like 2 [Source:Xenbase;Acc:XB-GENE-921456])

HSP 1 Score: 205.682 bits (522), Expect = 2.000e-60
Identity = 110/289 (38.06%), Postives = 170/289 (58.82%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS--VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNE 993
            ++Y  +  IG+G+FG  Y  K     +      V+KE+N+  M   + E   +E  LL+K+ H NIV FF S    N   I+ EYC+GGDL + + K +  G   EE +I+ WF+Q+  GL +IH RK+LHRD+K  NIFL  +    K+GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  +DIWS G +LYE+CALKH F   +L ++++ I       IP+ YS +L+ ++  +      +RP    IL  PF++ +I       +  ++ S T+++ +
Sbjct:    2 DKYDIVRMIGEGAFGKAYLAKG----KSDNMQCVIKEINLSKMPTKEKEASHKEVVLLAKMKHPNIVTFFSSIEERNKLYIVMEYCDGGDLMKRVNKQR--GVLFEEDQILSWFVQISLGLKHIHDRKVLHRDIKAQNIFLSNNGTLAKLGDFGIARMLNNTMELARTCVGTPYYLSPEICENKPYNNKTDIWSLGCVLYELCALKHPFEASSLRQLVLKICRGRYEPIPTKYSYDLRILVSQLFKISSRDRPSINSILKKPFLEKRINKHLSPELIEEEFSHTVIHRK 284

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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: nek1 (NIMA-related kinase 1 [Source:NCBI gene;Acc:100036653])

HSP 1 Score: 218.394 bits (555), Expect = 1.429e-59
Identity = 111/267 (41.57%), Postives = 168/267 (62.92%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            N+Y+ +S IG+GSFG    VK     +G++   V+KE+ +  M   + EE  RE  +L+ + H NIV++ +SF       I+ +YCEGGDL + I   K  G    E +I+ WF+Q+   L ++H RKILHRD+K  NIFL K  ++++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+ PFI  +I
Sbjct:    2 NKYVRVSKIGEGSFGKAILVKSKD--DGKQY--VIKEIGISKMSNKEREESRREVAVLANMKHPNIVQYQESFEESGCLYIVMDYCEGGDLFKRINSQK--GVLFSEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKGGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENRPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSYDLRNLLSMLFKRNPRDRPSVNSILEKPFIYRRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: nek1 (NIMA-related kinase 1 [Source:NCBI gene;Acc:100036653])

HSP 1 Score: 218.009 bits (554), Expect = 1.485e-59
Identity = 111/267 (41.57%), Postives = 168/267 (62.92%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            N+Y+ +S IG+GSFG    VK     +G++   V+KE+ +  M   + EE  RE  +L+ + H NIV++ +SF       I+ +YCEGGDL + I   K  G    E +I+ WF+Q+   L ++H RKILHRD+K  NIFL K  ++++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+ PFI  +I
Sbjct:    2 NKYVRVSKIGEGSFGKAILVKSKD--DGKQY--VIKEIGISKMSNKEREESRREVAVLANMKHPNIVQYQESFEESGCLYIVMDYCEGGDLFKRINSQK--GVLFSEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKGGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENRPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSYDLRNLLSMLFKRNPRDRPSVNSILEKPFIYRRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek11 (NIMA (never in mitosis gene a)-related expressed kinase 11 [Source:MGI Symbol;Acc:MGI:2442276])

HSP 1 Score: 281.952 bits (720), Expect = 8.487e-89
Identity = 140/336 (41.67%), Postives = 212/336 (63.10%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMS----ETLVNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKA 1119
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLS+L+H  IV+F  SF  +  +CIITEYCEG DL   I++ K +G    E +I+ WFIQ++ G+DY+H+R+ILHRDLK  NIFLK + +KIGDFG+SR+L  + +LA+T  GTP+YMSPE LKH GY+  SDIWS   ILYEMC L HAF G + + V++ I+E   P +P  Y   L  ++E +L K P  RP A +IL  P+++ +++   + + +  +M+     ++   E+    N + K   L  + A S   + TP++++ L+K   AD++A
Sbjct:   27 ARRYVLQQKLGSGSFGTVYLVSDKKAKPGEE-LKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYMEEQLQ---LLMCKYPEMTLEDKNSVCQKEAAHTINAVQKKLHLQTLQALSDTQKTTPRERMWLRKLQAADERA 358

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek11 (NIMA (never in mitosis gene a)-related expressed kinase 11 [Source:MGI Symbol;Acc:MGI:2442276])

HSP 1 Score: 288.115 bits (736), Expect = 6.123e-88
Identity = 144/358 (40.22%), Postives = 223/358 (62.29%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMS----ETLVNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLK 1185
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLS+L+H  IV+F  SF  +  +CIITEYCEG DL   I++ K +G    E +I+ WFIQ++ G+DY+H+R+ILHRDLK  NIFLK + +KIGDFG+SR+L  + +LA+T  GTP+YMSPE LKH GY+  SDIWS   ILYEMC L HAF G + + V++ I+E   P +P  Y   L  ++E +L K P  RP A +IL  P+++ +++   + + +  +M+     ++   E+    N + K   L  + A S   + TP++++ L+K   AD++A   ++  E+ +K N +  + L+
Sbjct:   27 ARRYVLQQKLGSGSFGTVYLVSDKKAKPGEE-LKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYMEEQLQ---LLMCKYPEMTLEDKNSVCQKEAAHTINAVQKKLHLQTLQALSDTQKTTPRERMWLRKLQAADERARRLKKIAEENYKENDKRMQALR 380

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1 [Source:MGI Symbol;Acc:MGI:97303])

HSP 1 Score: 218.779 bits (556), Expect = 7.149e-60
Identity = 109/266 (40.98%), Postives = 168/266 (63.16%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            +Y+ L  IG+GSFG    VK     +G+    V+KE+N+  M   + +E  RE  +L+ + H NIV++ +SF    +  I+ +YCEGGDL + I   K  G+  +E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYE+C LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+  FI  +I
Sbjct:    3 KYVRLQKIGEGSFGKAVLVKSTE--DGRHY--VIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQK--GALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1 [Source:MGI Symbol;Acc:MGI:97303])

HSP 1 Score: 218.779 bits (556), Expect = 7.311e-60
Identity = 109/266 (40.98%), Postives = 168/266 (63.16%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            +Y+ L  IG+GSFG    VK     +G+    V+KE+N+  M   + +E  RE  +L+ + H NIV++ +SF    +  I+ +YCEGGDL + I   K  G+  +E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYE+C LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+  FI  +I
Sbjct:    3 KYVRLQKIGEGSFGKAVLVKSTE--DGRHY--VIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQK--GALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1 [Source:MGI Symbol;Acc:MGI:97303])

HSP 1 Score: 218.779 bits (556), Expect = 7.755e-60
Identity = 109/266 (40.98%), Postives = 168/266 (63.16%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            +Y+ L  IG+GSFG    VK     +G+    V+KE+N+  M   + +E  RE  +L+ + H NIV++ +SF    +  I+ +YCEGGDL + I   K  G+  +E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYE+C LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+  FI  +I
Sbjct:    3 KYVRLQKIGEGSFGKAVLVKSTE--DGRHY--VIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQK--GALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8NG66|NEK11_HUMAN (Serine/threonine-protein kinase Nek11 OS=Homo sapiens OX=9606 GN=NEK11 PE=1 SV=2)

HSP 1 Score: 309.301 bits (791), Expect = 4.990e-95
Identity = 153/360 (42.50%), Postives = 232/360 (64.44%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K++G    E +II WFIQ++ G+DY+H+R+ILHRDLK  N+FLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P++  ++++      E     + L    E+  I N + K   L  + A S   ++TP++++ L+K   AD+KA + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQ 384

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8WNU8|NEK11_MACFA (Serine/threonine-protein kinase Nek11 OS=Macaca fascicularis OX=9541 GN=NEK11 PE=2 SV=1)

HSP 1 Score: 304.679 bits (779), Expect = 2.373e-93
Identity = 152/360 (42.22%), Postives = 230/360 (63.89%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETL-VNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQ 1200
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLSKL+H  IVKF  SF  ++N+CIITEYCEG DL   I++ K +G    + +II WFIQ++ G+DY+H+R+ILHRDLK  NIFLK + +KIGDFG+SR+L  + DLA+T  GTP+YMSPE LKH GY+T SDIWS   ILYEMC + HAF G N + +++ I+E   P +P  Y + L  ++E +L K+P  RP A EIL +P+I  +++       E     + L    E+  + N + K   L  + A S   ++TP++++ L+K   AD++A + ++ +E+ ++ N +  ++L+   FQ
Sbjct:   26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEE-LKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDYKIQEYKEAGKIFPDNQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNTIMESMLNKNPSLRPSAIEILKIPYIDEQLQHLMCRHSEMTLEDKNLDCQKEAARLINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADERARKLKKIVEEKYEENSKRMQELRSRNFQ 384

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8C0Q4|NEK11_MOUSE (Serine/threonine-protein kinase Nek11 OS=Mus musculus OX=10090 GN=Nek11 PE=2 SV=2)

HSP 1 Score: 288.115 bits (736), Expect = 4.283e-87
Identity = 144/358 (40.22%), Postives = 223/358 (62.29%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMS----ETLVNNESKDISNFLSKSTGLNIITAAS--VELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLK 1185
              RY+    +G GSFGTVY V D +   G+E +KVLKE++V  ++ ++  +   E +LLS+L+H  IV+F  SF  +  +CIITEYCEG DL   I++ K +G    E +I+ WFIQ++ G+DY+H+R+ILHRDLK  NIFLK + +KIGDFG+SR+L  + +LA+T  GTP+YMSPE LKH GY+  SDIWS   ILYEMC L HAF G + + V++ I+E   P +P  Y   L  ++E +L K P  RP A +IL  P+++ +++   + + +  +M+     ++   E+    N + K   L  + A S   + TP++++ L+K   AD++A   ++  E+ +K N +  + L+
Sbjct:   27 ARRYVLQQKLGSGSFGTVYLVSDKKAKPGEE-LKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDIWSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAADILKAPYMEEQLQ---LLMCKYPEMTLEDKNSVCQKEAAHTINAVQKKLHLQTLQALSDTQKTTPRERMWLRKLQAADERARRLKKIAEENYKENDKRMQALR 380

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q86I06|NEK3_DICDI (Probable serine/threonine-protein kinase nek3 OS=Dictyostelium discoideum OX=44689 GN=nek3 PE=3 SV=1)

HSP 1 Score: 222.631 bits (566), Expect = 1.569e-60
Identity = 120/267 (44.94%), Postives = 163/267 (61.05%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS----VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHD-GYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFI 918
            ++Y  +  IGKGSFG    VK  R  +G   + VLKE+NV  M   +  +   E  LLS L+H NI+ ++DSF L     II EY   GD+   I+K         E  I+ WF Q+ + L YI  R ILHRDLK  NIFL   +    +K+GDFGI++ILN    LAST LGTPYY+SPE+++++ GY+  SDIWS G +LYE+  LKHAF   NL  +++ IL+   P IPS+YS +L+ ++  +L  DP NRP   +IL+LPFI
Sbjct:    2 DKYEEIKTIGKGSFGRAILVK--RKSDGL--LLVLKEINVMEMQPKERSDAMNEVNLLSMLDHENIIGYYDSFILNGCLYIIMEYANAGDINLEIKKRTLQNKTFSEFEILSWFSQICKALQYISSRNILHRDLKTQNIFLSIVNGDYFIKLGDFGIAKILNSETSLASTVLGTPYYLSPELIQNEKGYDHKSDIWSLGCVLYELTTLKHAFNAANLPALVLKILKGTYPPIPSHYSNDLRNLISSMLQIDPKNRPSVNDILELPFI 264

[Close]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|P51954|NEK1_MOUSE (Serine/threonine-protein kinase Nek1 OS=Mus musculus OX=10090 GN=Nek1 PE=1 SV=2)

HSP 1 Score: 218.779 bits (556), Expect = 5.114e-59
Identity = 109/266 (40.98%), Postives = 168/266 (63.16%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            +Y+ L  IG+GSFG    VK     +G+    V+KE+N+  M   + +E  RE  +L+ + H NIV++ +SF    +  I+ +YCEGGDL + I   K  G+  +E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYE+C LKHAF   N+  +++ I+    P +  +YS +L+ +L  +  ++P +RP    IL+  FI  +I
Sbjct:    3 KYVRLQKIGEGSFGKAVLVKSTE--DGRHY--VIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQK--GALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1I8G9L5 (Protein kinase domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 332.028 bits (850), Expect = 2.149e-101
Identity = 184/428 (42.99%), Postives = 243/428 (56.78%), Query Frame = 1

Query:  121 RHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDD---------MSETLVNNESKDISNFLSKSTGLNIITAASV------------------------------------ELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSS--------------LPFTNQR 1227
            R   NRY  +  IGKG+FGTV+ V+D R  E  E  KVLKEV +  +D D+  E   E KLL KL+HS I+KF++ F    ++CI+TEYC+ GDL Q I + K++G +L     IRWFIQ++ G+DY+H R+ILHRDLK  NIFLK  +VKIGDFGISR+L   +D+ASTFLGTPY+MSPE+LKH+GYN  SDIWS G ILYEMCAL+HAF G  LM ++ +I  +PCP IP  Y   LQ VLE +L KDP +R  A E+L  PFI+ +++    + VE+           M ET+   ESK++ + L +   LN +   S                                      L+P QK+LL+K  EAD +A E      +T + N E  +K     F+ S              LP  NQR
Sbjct:   15 RVLSNRYRVVRQIGKGAFGTVHLVEDLRSSE--EKFKVLKEVQIGEVDPDETLEVVHEAKLLGKLDHSAILKFYNCFMEPPSFCIVTEYCDEGDLDQCISRLKQAGHNLPVQTTIRWFIQILLGVDYLHGRRILHRDLKTKNIFLKSGTVKIGDFGISRVLMSNSDMASTFLGTPYFMSPELLKHEGYNAKSDIWSVGCILYEMCALEHAFKGAGLMGILFSICGNPCPVIPDRYPPELQAVLEKMLAKDPQDRLSAREVLKEPFIREQMQS-LREAVESQSGGNRQQQLLMEETINEAESKNLLSVLQEKPTLNSLEFESRAMAAAAAAAAEVTLKPNSDTVRQKVKGPGQAGGDFNALSPHQKMLLRKQREADDRARELATQAAETSRRNAELAKKFGNRTFRPSGSEGRTAFPQPQDDLPVRNQR 439

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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267F3B3 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005885g2 PE=4 SV=1)

HSP 1 Score: 332.798 bits (852), Expect = 4.519e-101
Identity = 184/428 (42.99%), Postives = 243/428 (56.78%), Query Frame = 1

Query:  121 RHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDD---------MSETLVNNESKDISNFLSKSTGLNIITAASV------------------------------------ELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSS--------------LPFTNQR 1227
            R   NRY  +  IGKG+FGTV+ V+D R  E  E  KVLKEV +  +D D+  E   E KLL KL+HS I+KF++ F    ++CI+TEYC+ GDL Q I + K++G +L     IRWFIQ++ G+DY+H R+ILHRDLK  NIFLK  +VKIGDFGISR+L   +D+ASTFLGTPY+MSPE+LKH+GYN  SDIWS G ILYEMCAL+HAF G  LM ++ +I  +PCP IP  Y   LQ VLE +L KDP +R  A E+L  PFI+ +++    + VE+           M ET+   ESK++ + L +   LN +   S                                      L+P QK+LL+K  EAD +A E      +T + N E  +K     F+ S              LP  NQR
Sbjct:   20 RVLSNRYRVVRQIGKGAFGTVHLVEDLRSSE--EKFKVLKEVQIGEVDPDETLEVVHEAKLLGKLDHSAILKFYNCFMEPPSFCIVTEYCDEGDLDQCISRLKQAGHNLPVQTTIRWFIQILLGVDYLHGRRILHRDLKTKNIFLKSGTVKIGDFGISRVLMSNSDMASTFLGTPYFMSPELLKHEGYNAKSDIWSVGCILYEMCALEHAFKGAGLMGILFSICGNPCPVIPDRYPPELQAVLEKMLAKDPQDRLSAREVLKEPFIREQMQS-LREAVESQSGGNRQQQLLMEETINEAESKNLLSVLQEKPTLNSLEFESRAMAAAAAAAAEVTLKPNSDTVRQKVKGPGQAGGDFNALSPHQKMLLRKQREADDRARELATQAAETSRRNAELAKKFGNRTFRPSGSEGRTAFPQPQDDLPVRNQR 444

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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267F7N0 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig005885g1 PE=4 SV=1)

HSP 1 Score: 332.798 bits (852), Expect = 5.043e-101
Identity = 184/428 (42.99%), Postives = 243/428 (56.78%), Query Frame = 1

Query:  121 RHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDD---------MSETLVNNESKDISNFLSKSTGLNIITAASV------------------------------------ELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSS--------------LPFTNQR 1227
            R   NRY  +  IGKG+FGTV+ V+D R  E  E  KVLKEV +  +D D+  E   E KLL KL+HS I+KF++ F    ++CI+TEYC+ GDL Q I + K++G +L     IRWFIQ++ G+DY+H R+ILHRDLK  NIFLK  +VKIGDFGISR+L   +D+ASTFLGTPY+MSPE+LKH+GYN  SDIWS G ILYEMCAL+HAF G  LM ++ +I  +PCP IP  Y   LQ VLE +L KDP +R  A E+L  PFI+ +++    + VE+           M ET+   ESK++ + L +   LN +   S                                      L+P QK+LL+K  EAD +A E      +T + N E  +K     F+ S              LP  NQR
Sbjct:   21 RVLSNRYRVVRQIGKGAFGTVHLVEDLRSSE--EKFKVLKEVQIGEVDPDETLEVVHEAKLLGKLDHSAILKFYNCFMEPPSFCIVTEYCDEGDLDQCISRLKQAGHNLPVQTTIRWFIQILLGVDYLHGRRILHRDLKTKNIFLKSGTVKIGDFGISRVLMSNSDMASTFLGTPYFMSPELLKHEGYNAKSDIWSVGCILYEMCALEHAFKGAGLMGILFSICGNPCPVIPDRYPPELQAVLEKMLAKDPQDRLSAREVLKEPFIREQMQS-LREAVESQSGGNRQQQLLMEETINEAESKNLLSVLQEKPTLNSLEFESRAMAAAAAAAAEVTLKPNSDTVRQKVKGPGQAGGDFNALSPHQKMLLRKQREADDRARELATQAAETSRRNAELAKKFGNRTFRPSGSEGRTAFPQPQDDLPVRNQR 445

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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A267G446 (Protein kinase domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig018929g1 PE=4 SV=1)

HSP 1 Score: 329.717 bits (844), Expect = 7.977e-100
Identity = 182/428 (42.52%), Postives = 242/428 (56.54%), Query Frame = 1

Query:  121 RHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDD---------MSETLVNNESKDISNFLSKSTGLNIITAASV------------------------------------ELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSS--------------LPFTNQR 1227
            R   NRY  +  IGKG+FGTV+ V+D R  E  E  KVLKEV +  +D D+  E   E KLL KL+HS I+KF++ F    ++CI+TEYC+ GDL Q I + K++G +L     IRWFIQ++ G+DY+H R+ILHRDLK  NIFLK  +VKIGDFGISR+L   +D+ASTFLGTPY+MSPE+LKH+GYN  SDIWS G ILYEMCAL+HAF G  LM ++ +I  +PCP IP  Y   LQ VLE +L KDP +R  A E+L  PF++ +++    + VE+           M ET+    SK++ + L +   LN +   S                                      L+P QK+LL+K  EAD +A E      +T + N E  +K     F+ S              LP  NQR
Sbjct:   21 RVLSNRYRVVRQIGKGAFGTVHLVEDLRSSE--EKFKVLKEVQIGEVDPDETLEVVHEAKLLGKLDHSAILKFYNCFMEPPSFCIVTEYCDEGDLDQCISRLKQAGHNLPVQTTIRWFIQILLGVDYLHGRRILHRDLKTKNIFLKSGTVKIGDFGISRVLMSNSDMASTFLGTPYFMSPELLKHEGYNAKSDIWSVGCILYEMCALEHAFKGAGLMGILFSICGNPCPVIPDRYPPELQAVLEKMLAKDPQDRLSAREVLKEPFVREQMQS-LREAVESQSGGNRQQQLLMEETINEAASKNLLSVLQEKPTLNSLEFESRAMAAAAAAAAEVTLKPNSDTVRQKVKGPGQAGGDFNALSPHQKMLLRKQREADDRARELATQAAETSRRNAELAKKFGNRTFRPSGSEGRTAFPQPQDDLPVRNQR 445

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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A1S3JN97 (serine/threonine-protein kinase Nek11 OS=Lingula unguis OX=7574 GN=LOC106174714 PE=4 SV=1)

HSP 1 Score: 318.546 bits (815), Expect = 3.898e-96
Identity = 162/374 (43.32%), Postives = 242/374 (64.71%), Query Frame = 1

Query:  130 GNRYIFLSGIGKGSFGTVYKVKDFR--GPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDP--WIDIVENDDMSETLVNN-ESKDISNFLSKSTGLNIITAASVE-----LTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSSLPFTN 1221
             NRY     +G G+FGT + VKD +   P+  E  KV+KE+ V  +  D+  +   E  LLSKL+H +IVKF+DSF     +CI+TEYC+GGDL+  I K ++ G  L+E+ ++ WF+Q++  + Y+H R++LHRDLK  NIFL+ + VKIGDFGISRIL  T+D+ASTF GTPYYMSPEVLKH+GYN+ SD+WS G ILYE+CAL+HAF G +LM VM  I+E   P++P  Y + LQ VL+ +LVK+P+ RP A E+  +PF+   I      I +    DM E   +  E+++I N L K T L  +  +  +     L+P++++ ++K  +AD++ ++  E + ++++       +LK+DQ +SS   +N
Sbjct:   25 ANRYQVERKLGSGNFGTAFLVKDLKCKDPKDPEQWKVMKEIPVGDLQPDETVDAMHEANLLSKLDHPSIVKFYDSFLDGEFFCIVTEYCDGGDLEDQIIKYRKEGKALDEILVMDWFVQLLLAVQYMHSRRVLHRDLKTRNIFLRNNMVKIGDFGISRILMGTSDMASTFTGTPYYMSPEVLKHEGYNSKSDVWSIGCILYELCALQHAFEGQSLMGVMYKIVEGTSPQLPDKYCKELQGVLKLMLVKEPEKRPSATELTKVPFVHRHIEKLKNTIQVKHKKDMQEKEGHRKEAEEIDNLLRKKTHLQTLRDSEEDVKWKNLSPRERMRIRKQQKADEEKKKLEEAVRQSYEET-----QLKKDQIKSSFLTSN 393

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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek1 (NIMA related kinase 1 [Source:NCBI gene;Acc:103028272])

HSP 1 Score: 224.557 bits (571), Expect = 7.684e-62
Identity = 128/375 (34.13%), Postives = 206/375 (54.93%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSK--STGLNIITAASVELTPKQK----ILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSSLPFTNQRNAS 1236
            ++Y  +  IG+GSFG    V+     +G +   V+KE+ +  M   + +E  +E  +L+ ++H NIV++ +SF       I+ +YCEGGDL + I   K  G    E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D ++++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS++L+ +L  +  ++P  RP  C ILD PF+  +I       +   + S++L+           +K  + G + IT A     P  K    + +K+  +A +K       +  + K  VE +  +K    Q+  P   QR  S
Sbjct:    2 DKYEKVKKIGEGSFGKAILVRSKE--DGHQY--VIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEEGGCLYIVMDYCEGGDLFKKINNQK--GVLFTEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSMHYSQDLRSLLGLLFKRNPRERPSVCTILDKPFLAHRIHRFLSPQLIAQEFSQSLLRQPKTPAQGLPAKRPAPGPSPITPAQKITKPAAKYGVPLTVKRPADAGRK-------VADSAKKQVERKPGIKLK--QAPPPAAGQRRVS 361

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek1 (NIMA related kinase 1 [Source:NCBI gene;Acc:103028272])

HSP 1 Score: 221.476 bits (563), Expect = 6.742e-61
Identity = 121/346 (34.97%), Postives = 199/346 (57.51%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSK--STGLNIITAASVELTPKQK----ILLKKSMEADKK-AEEQREYIEK 1146
            ++Y  +  IG+GSFG    V+     +G +   V+KE+ +  M   + +E  +E  +L+ ++H NIV++ +SF       I+ +YCEGGDL + I   K  G    E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D ++++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SDIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS++L+ +L  +  ++P  RP  C ILD PF+  +I       +   + S++L+           +K  + G + IT A     P  K    + +K+  +A +K A+  ++ +E+
Sbjct:    2 DKYEKVKKIGEGSFGKAILVRSKE--DGHQY--VIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKESFEEGGCLYIVMDYCEGGDLFKKINNQK--GVLFTEEQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSMHYSQDLRSLLGLLFKRNPRERPSVCTILDKPFLAHRIHRFLSPQLIAQEFSQSLLRQPKTPAQGLPAKRPAPGPSPITPAQKITKPAAKYGVPLTVKRPADAGRKVADSAKKQVER 341

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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek4 (NIMA related kinase 4 [Source:NCBI gene;Acc:103043005])

HSP 1 Score: 215.698 bits (548), Expect = 7.509e-60
Identity = 109/268 (40.67%), Postives = 165/268 (61.57%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYC---IITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            Y F+  +GKGS+G V  V+     +      V+K++N+ T  + +     +E +LLS+L H NIV + +S+  E + C   I+  +CEGGDL   +++ K  G  L E +++ WF+Q+   L Y+H++ ILHRDLK  NIFL K + +K+GD GI+R+L   ND+AST +GTPYYMSPE+  +  YN  SD+W+ G  +YEM  LKHAF   ++  +   I+E   P++PS Y   L E+++ +L K P++RP    IL  PFIK +I
Sbjct:    4 YGFIRVVGKGSYGEVNLVQH----KSDRKQYVIKKLNLRTSSKRERRAAEQEAQLLSQLKHPNIVTYRESW--EGDDCQLYIVMGFCEGGDLYHRLKQQK--GELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMSTLKHAFNAKDMNSLAFRIIEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQPFIKQQI 263

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: nek4 (NIMA related kinase 4 [Source:NCBI gene;Acc:103043005])

HSP 1 Score: 215.698 bits (548), Expect = 1.115e-59
Identity = 109/268 (40.67%), Postives = 165/268 (61.57%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYC---IITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            Y F+  +GKGS+G V  V+     +      V+K++N+ T  + +     +E +LLS+L H NIV + +S+  E + C   I+  +CEGGDL   +++ K  G  L E +++ WF+Q+   L Y+H++ ILHRDLK  NIFL K + +K+GD GI+R+L   ND+AST +GTPYYMSPE+  +  YN  SD+W+ G  +YEM  LKHAF   ++  +   I+E   P++PS Y   L E+++ +L K P++RP    IL  PFIK +I
Sbjct:    4 YGFIRVVGKGSYGEVNLVQH----KSDRKQYVIKKLNLRTSSKRERRAAEQEAQLLSQLKHPNIVTYRESW--EGDDCQLYIVMGFCEGGDLYHRLKQQK--GELLPERQVVEWFVQIAMALQYLHEKHILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMSTLKHAFNAKDMNSLAFRIIEGKLPQMPSKYDPQLGELIKRMLCKKPEDRPDVKHILRQPFIKQQI 263

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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000049860.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000129.1:61559:73217:-1 gene:ENSAMXG00000043136.1 transcript:ENSAMXT00000049860.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 206.068 bits (523), Expect = 1.134e-56
Identity = 109/310 (35.16%), Postives = 178/310 (57.42%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKY--DSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSKSTGLNIITAAS 1056
            N Y  +  IG G++G    V++     G     V+K+++   M   + E+  +E  LLSK+ H NIV FF SF   N+  I+ EYC+GGDL + I  + + G   +E +I+ WF+Q+  GL +IH RK+LHRD+K  NIFL      VK+GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  +D+WS G +LYE+C L+H F G +L +++V I +     +   YS +L+ ++  +    P +RP    +L  P + + I       +  ++ S T+++   K ++    K + ++ ++  S
Sbjct:    2 NEYELVRQIGHGAYGKALLVRER---SGNARHCVIKQISWSRMSPREREDSKKEVTLLSKMKHPNIVAFFRSFNERNSLYIVMEYCDGGDLMKKI--SMQRGQPFKEQQIMDWFVQICLGLKHIHDRKVLHRDIKAQNIFLTQGGSKVKLGDFGIARLLNNTVELARTCVGTPYYLSPEICENRPYNNKTDMWSLGCVLYELCTLRHPFEGSSLRQLIVRICKGYYTPVSQRYSSDLRTLVSQLFKISPRDRPSVNSLLKRPLLHTLISKHLHPQLMEEEFSHTVLHR-VKPVAQPGPKHSAVSKVSPRS 305

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007414.1 (pep scaffold:Pmarinus_7.0:GL476981:230882:244405:1 gene:ENSPMAG00000006689.1 transcript:ENSPMAT00000007414.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 213.386 bits (542), Expect = 3.887e-64
Identity = 106/265 (40.00%), Postives = 160/265 (60.38%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSK 927
            RY  +S IG+GSFG    VK     +    + V+KE+N+  M   + +E  +E  +L+ + H NIV + +SF    N  I+ +YCEGGDL + I   K  G    E +I+ W +Q+   L ++H RKILHRD+K  NIFL K   V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN  SD+W+ G +LYEMC L+HAF   N+  +++ I+    P + ++YS  L+  L  +L +DP  RP    +L  P + ++
Sbjct:    3 RYTMVSQIGEGSFGKAMLVKS----KADGHLYVIKEINISRMSPKERDEARKEVCVLANMRHPNIVSYKESFEERGNLYIVMDYCEGGDLFKRINAQK--GVLFSEDQILDWLVQLCLALKHVHDRKILHRDIKSQNIFLTKAGIVQLGDFGIARVLNSTTELARTCIGTPYYLSPEICENKPYNHKSDMWALGCVLYEMCTLRHAFEAGNMKNLVLKIIRGSFPPVSAHYSSELRSTLSGLLRRDPRARPPVAVLLSRPLLMAR 261

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: NEK9 (NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591])

HSP 1 Score: 174.096 bits (440), Expect = 3.384e-46
Identity = 100/268 (37.31%), Postives = 161/268 (60.07%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCP-RIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRD 936
            YI +  +G+G+FG   +   +R  E   S+ V KE+++  +   +  +   E  +LS L H+NI+ +++ F   N   I  EYC GG L + I   K+ G+   E  I+ +F Q++  ++ IH  KILHRD+K  NIFL K D +K+GDFGIS+IL+  + +A +++GTPYYMSPE+++ D YNT SDIW+ G +LYE+  L   F   N +++   I+       I   YS+ ++EV++  L +D + RP A ++L+L  IK++ R+
Sbjct:   36 YIPVRVLGRGAFG---EAALYRRNE-DNSLVVWKEIDLTRLSDKERRDSQNEIDILSLLEHANIISYYNHFLDGNVLLIELEYCNGGTLYEKI--IKQHGAFFPEKDIVWYFYQLVSAVEQIHNFKILHRDIKTLNIFLTKSDLIKVGDFGISKILDSRSQMAESYVGTPYYMSPELIRGDKYNTKSDIWAMGCVLYELLTLTRTFDATNPLKLCYEIIHGKKQVEIDDQYSKEIKEVVQKCLQQDAEQRPTAEDLLELSPIKTRRRE 297

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: nek2 (NIMA-related kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-752])

HSP 1 Score: 165.622 bits (418), Expect = 3.376e-45
Identity = 90/220 (40.91%), Postives = 123/220 (55.91%), Query Frame = 1

Query:  226 IKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSF--RLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRK-----ILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECIL 861
            + V K ++  TM + + +    E  LL +L H NIV++FD    R      I+ EYCE GDL  +I + +R    LEE  ++R   Q++  L   H+R      +LHRDLKP N+FL    +VK+GDFG++RIL      A TF+GTPYYMSPE      YN  SDIWS G +LYE+CAL   F   N  ++   I E    RIP  YS+ L E++  +L
Sbjct:    2 VLVWKVLDYGTMSEPEKQMLVSEVNLLRELKHPNIVRYFDRIIDRSNTTLYIVMEYCECGDLASLISRCRRDRRFLEEEFVLRVLAQLVLALRECHRRTAGGRTVLHRDLKPANVFLDARHNVKLGDFGLARILQHDTSFAKTFVGTPYYMSPEQFSRMSYNEKSDIWSLGCLLYELCALVPPFTAMNQKQLAEKIKEGKFRRIPYRYSDELNEIISKML 221

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000555.1 (pep scaffold:Pmarinus_7.0:GL477093:35206:42652:1 gene:ENSPMAG00000000500.1 transcript:ENSPMAT00000000555.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 141.739 bits (356), Expect = 1.829e-39
Identity = 69/182 (37.91%), Postives = 113/182 (62.09%), Query Frame = 1

Query:  406 KQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMR-----VMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIR 933
            KQ+I KT           +++WF+QV   + YIH  KILHRD+K +N+FL K  +VK+GDFGIS+ +  T D+A T +GTPYY+SPE+ +   Y++ SD+W+ G +LYE+CAL+ AF   N++R     +   I+      +  +YS +++ ++  +L + P++RP A  +L  P+ +  +R
Sbjct:    2 KQIITKTN----------VMQWFVQVCMAVQYIHSVKILHRDIKTSNVFLTKAGTVKVGDFGISKAMEGTLDMAVTCVGTPYYLSPEMCQDLPYSSKSDVWALGCLLYELCALRPAFEASNIIRLTRRSLFYKIMRGEPDPLDESYSRDVRALVALLLSRSPEDRPSASAVLASPYAQRHLR 173

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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: STK36 (serine/threonine kinase 36 [Source:HGNC Symbol;Acc:HGNC:17209])

HSP 1 Score: 146.362 bits (368), Expect = 1.115e-36
Identity = 110/381 (28.87%), Postives = 187/381 (49.08%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKV-KDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSKSTGLNIITAASVELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENR-RKLKQDQFQSSLPFTNQRNASTRSSISEYDEL 1269
            +Y  L  IG+GSFG VYK  K + G      +  LK +        ++    RE  ++  L H NIV+  DSF  +    ++T+Y EG +L Q++E       +L E ++     Q++  L Y+H  +ILHRD+KP NI L K   VK+ DFG +R ++    + ++  GTP YMSPE+++   Y+  +D+WS G ILYE+      F  +++ +++  I++ P  + P N S   +  L+ +L K+P  R     +L  PF+  K        +  DD+S    N  ++D+S  L          AA +  T  Q  +L+K+ +  K AE  +   +     N   R R + +++  S    +++  +  + ++S  D L
Sbjct:    3 KYHVLEMIGEGSFGKVYKGRKRYTG-----QVVALKFIPKVGRSDKELRNLRREIDIMRGLQHPNIVQMLDSFETDKEVVVVTDYAEG-ELFQILED----DGNLPEEQVREIACQLVSALYYLHSHRILHRDMKPQNILLGKGGVVKLCDFGFARAMSINTLVLTSIKGTPLYMSPELVEEKPYDHTADLWSMGCILYELFVGTPPFYTNSIFQLVSLIIKDPV-KWPKNMSSEFRNFLQGLLTKEPKLRLSWPALLHHPFVAGK------SSIVLDDISAEETNPLTEDLSPELQAQKEKQ---AAELAPTSGQSKILRKARQ--KMAEVAKNKEKDNQCGNAPQRQRGVLEEKASSHSALSSKHKSMAKQAVSSADTL 361

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIN3 (Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol [Source:SGD;Acc:S000000071])

HSP 1 Score: 141.739 bits (356), Expect = 4.883e-37
Identity = 93/318 (29.25%), Postives = 141/318 (44.34%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFF--DSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIH---------------------KRKILHRDLKPNNIFLKYDS----------------------------------------VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEIL 903
            Y  L  IG+GSFG+V KV         + + V K++    M+  + ++   E  +LS+L H NIV+F+  D    +    +  EYC  GDL Q+I+  K+   ++ E  +     Q++  L   H                     K  ++HRDLKP NIFL YD                                         VK+GDFG+++ L  +   A+T++GTPYYMSPEVL    Y+  SDIWS G +++EMC+L   F   N + +   I    C  +P  YS  L  ++  ++  +   RP   E+L
Sbjct:   25 YQVLEEIGRGSFGSVRKVIHI----PTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMIDVNLRTRPSTFELL 338

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 139.813 bits (351), Expect = 6.586e-36
Identity = 88/264 (33.33%), Postives = 144/264 (54.55%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVL--KHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIK 921
            Y   S IG+G+FG VYK  D       + I  +K VN++  D+D IE   +E   L++L    I  +  +   + +  I+ EYC GG    +++++  +G  L E ++     +V  GL Y+H+++ +HRD+K  NI L  +  VK+GDFG+S  +  T     TF+GTPY+M+PEV+  + DGYN  +DIWS G+  YE+          + M+VM  + +   P++   +S+  ++ +   LVK P +RP A  +L   F+K
Sbjct:   18 YSIQSCIGRGNFGDVYKAVD----RVTQEIVAIKVVNLEHSDED-IELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNG--LPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLK-RDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVK 273

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 140.198 bits (352), Expect = 5.281e-35
Identity = 82/261 (31.42%), Postives = 139/261 (53.26%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSH--LEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRI--PSNYSENLQEVLECILVKDPDNRPKACEIL 903
            +Y  L  IG+G+ G VY   +     G      +K++N++   Q + E    E  ++    H NIV F DS+ L+ +  +I EY EGG L  V+       +H  L E +I     + + GL+++H + +LHRD+K +NI L  +  +K+ DFG    +N  N   +T +GTPY+M+PEV+    Y    DIWS G+++ EM   +  ++ +  +R +  I  +  P++  P N S +L++ L+  L  +P++R  A E+L
Sbjct:  619 KYANLVKIGQGASGGVYTAYEI----GTNVSVAIKQMNLE--KQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVV-------THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866

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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 138.658 bits (348), Expect = 1.589e-34
Identity = 88/268 (32.84%), Postives = 145/268 (54.10%), Query Frame = 1

Query:  157 IGKGSFGTVYK---VKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNH-SNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDG-YNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPS-NYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDP 939
            IG+G FG VYK   VK  R       +  +K +N+D+ D D++E+  RE + L+ L   SNI +++ S+  + +  II E+C GG L+ ++   K     ++E  I     +++  L  IHK  ++HRD+K  N+ +  +  VK+ DFG++  +N T+    T  GTPY+M+PEV+     Y+T  DIWS G+  YE+      +     +R M  I++S  PR+   +YS +L+E +   L +DP  R  A ++L   FI++    P
Sbjct:   29 IGRGKFGVVYKGYNVKTGR-------VYAIKVLNLDS-DSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-----IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATP 283

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CMK2 (Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005376])

HSP 1 Score: 132.109 bits (331), Expect = 1.484e-33
Identity = 88/272 (32.35%), Postives = 138/272 (50.74%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS----VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCP---RIP--SNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSK 927
            YIF   +G GSFG V + +     E   +IK+L +  +   +  Q++    E  +L KL+H NIV F D F  ++ + I+T+   GG+L   I     S     E+  +   +Q++  ++Y+H + ++HRDLKP N+     S    + I DFGI++ L    DL     G+  Y++PEVL  DG+    DIWS GVI Y +      FI +++   M     S  P    +P   N S +++  +   L  +P +RP A E+LD P+I SK
Sbjct:   47 YIFGRTLGAGSFGVVRQARKLSTNE-DVAIKILLKKALQG-NNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRI----LSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSK 312

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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO37069 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGU2])

HSP 1 Score: 284.263 bits (726), Expect = 1.386e-91
Identity = 142/268 (52.99%), Postives = 180/268 (67.16%), Query Frame = 1

Query:  127 WGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            + NRY  +  +G GSFGTV+ V+D +   G+   KVLKE+ V  +  D+  +  RE KLLSKLNH NIVKF DSF     +CI+TEYCEGGDL   I   ++SG   +E  I+ WFIQ++  + ++H+ +ILHRDLK  NIFLK + VK+GDFGISRIL  T+D+A+TF GTPYYMSPEVLKH+GYN  SDIWS GV+LYE+C L+HAF G +LM VM  I+E   P +   YS  LQ     ++ KDP  RP A EIL   FI   I
Sbjct:    2 YANRYRVVRRLGSGSFGTVFLVEDLKA-NGER--KVLKEIYVGELQPDETVDAMREAKLLSKLNHPNIVKFMDSFMDREYFCIVTEYCEGGDLDDKISAWRKSGKKFDESLILAWFIQIVLAVQHMHEMRILHRDLKTRNIFLKNNIVKLGDFGISRILMGTSDMATTFTGTPYYMSPEVLKHEGYNHKSDIWSLGVVLYELCNLQHAFQGQSLMGVMYKIVEGELPALSDKYSSQLQAFYSRLMDKDPKLRPSANEILKHHFIAENI 266

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG02])

HSP 1 Score: 213.001 bits (541), Expect = 4.098e-64
Identity = 109/268 (40.67%), Postives = 165/268 (61.57%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIIT-EYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            +RY     IGKGS+G V+  K     +  +   VLK+V++      + +    E KLLS+L H NIV + +SF+ +  +  I   +CEGGDL   ++  K  G  L+E +I+ WF+Q+   L Y+H++ ILHRDLK  NIFL K   +K+GD GI+R+L  ++D+A+T +GTPYYMSPE+  +  YN  SD+W+ G  LYEMC L+HAF   ++  ++  IL+   P +P  YS +L  +++ +L +DPD RP A  +L  P+IK +I
Sbjct:    4 DRYTIGKCIGKGSYGEVFLSKH----KKDKKQYVLKKVDLQKASVRERKAAELEAKLLSQLRHPNIVSYRESFQDDTGFLYIAMNFCEGGDLYSRLKAQK--GIPLDENQIVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKSKIIKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSNKPYNHKSDVWALGCCLYEMCTLRHAFNAKDMSSLVYKILKGKTPPLPKQYSTDLCSIIKSMLDQDPDKRPSASRLLRHPYIKKQI 265

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49822 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG20])

HSP 1 Score: 212.231 bits (539), Expect = 5.840e-64
Identity = 110/266 (41.35%), Postives = 170/266 (63.91%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            RY+ +  IG+GSFG    VK  +  +G+    V+KE+N+  M   + EE  +E K+LS+L H NIV + +SF    N  I+ +YC+GGDL + I   +  G    E +++ WF+Q+  GL ++H RKILHRD+K  NIFL ++  +K+GDFGI+R+L+ T +LA T +GTPYY+SPE++++  YN  SDIWS G +LYEM  LKHAF   N+  +++ I+    P IP  YS +++ ++  +L ++P +RP    +L   FI+ +I
Sbjct:    3 RYVRVKKIGEGSFGKALLVK--KRNDGKHY--VIKEINICRMKPREREESRKEVKVLSQLKHPNIVSYQESFEESGNLYIVMDYCDGGDLYKKINGQR--GIAFSEDQVMDWFVQICLGLKHVHDRKILHRDIKSQNIFLTRHGIIKMGDFGIARVLHSTVELARTCIGTPYYLSPEIVENRPYNNKSDIWSLGCVLYEMLTLKHAFEAGNMKNLVLKIIRGSYPPIPLRYSADIRMLVAQLLKRNPHDRPSVNTVLKKNFIQKRI 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49138 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH03])

HSP 1 Score: 200.675 bits (509), Expect = 8.134e-60
Identity = 111/273 (40.66%), Postives = 157/273 (57.51%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWID 948
            NRY  +  IGKG+FG+ + V+        + +  LKE+N   M  +       E K+LS L H NIV++ D+F     + I+ EY EGGDL     K K++       RI+ W  Q++  L +IH + ILHRDLK  NIFL K D VKIGDFGI+RIL+ T D A T +GTPYY+SPE+ +   YN  SDIW+ G +LYE+    H F  DNL  ++V IL    P IP  Y   L++++  +L  +P +RP A +++ +P +      P+ID
Sbjct:    2 NRYQKIDIIGKGTFGSAWLVES----RQSKRLYALKELNATAMPSEDRHLALNEVKILSTLKHRNIVRYRDAFEETGRFYIVMEYAEGGDLHT---KIKQAVEPFSSERILNWLAQLLLALKHIHGQNILHRDLKTQNIFLTKDDVVKIGDFGIARILDSTCDHARTTVGTPYYLSPEICQRQPYNNKSDIWALGCVLYELTTRTHPFTADNLTNLVVKILHGNYPPIPRFYGPLLEDLVAVMLKINPADRPSAKQLIYVPGLT-----PYID 262

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO34646 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNS0])

HSP 1 Score: 180.644 bits (457), Expect = 5.978e-52
Identity = 92/248 (37.10%), Postives = 145/248 (58.47%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNV-DTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDS-VKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGD--NLMRVMVTILESPCPRIPS-NYSENLQEVLECILVKDPDNRP 885
            IG+G F  VYK +          I  LK++ + D MD    ++C +E  LL +LNH N++K++ SF   N   I+ E  + GDL ++I+  K+    + E  + ++F+Q+   L+++H R+++HRD+KP N+F+     VK+GD G+ R  +     A + +GTPYYMSPE +K +GYN  SDIWS G +LYEM AL+  F GD  NL  +   I +   P +P+ +YS+ L+ ++   +   PD RP
Sbjct:   27 IGRGQFSVVYKAR----CTANNQIVALKKIQIFDMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLTAALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIKENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPAEHYSQQLRHLVSLCINPIPDQRP 270

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: nek4 (NIMA related kinase 4 [Source:NCBI gene;Acc:101169778])

HSP 1 Score: 217.624 bits (553), Expect = 2.452e-60
Identity = 109/268 (40.67%), Postives = 166/268 (61.94%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYC-IITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            N YIF+  +GKGS+G V  VK     +      V+K++N+ T  + +     +E +LLS+L H NIV + +S+  ++    I+  +CEGGDL   +++  R G  L E +++ WF+Q+   L Y+H+R ILHRDLK  NIFL K + +K+GD GI+R+L   ND+AST +GTPYYMSPE+  +  YN  SD+W+ G  +YEM  LKHAF   ++  ++  I+E   P++PS Y   L ++++ +L K P+ RP    IL  P+IK +I
Sbjct:    2 NSYIFIRVVGKGSYGEVNLVKH----KTDRKQYVIKKLNLSTSSKRERRSAEQEAQLLSQLRHPNIVTYRESWEGDDRQLYIVMGFCEGGDLYHRLKQ--RKGELLPERQVVEWFVQIAMALQYLHERNILHRDLKTQNIFLTKTNIIKVGDLGIARVLENQNDMASTLIGTPYYMSPELFSNKPYNHKSDVWALGCCVYEMSTLKHAFNAKDMNSLVYRIVEGKLPQMPSRYDPQLGDLIKSMLSKKPEERPDVKLILRQPYIKRQI 263

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000000545.2 (pep primary_assembly:ASM223467v1:4:1040495:1044496:1 gene:ENSORLG00000000439.2 transcript:ENSORLT00000000545.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 192.971 bits (489), Expect = 1.904e-56
Identity = 105/259 (40.54%), Postives = 159/259 (61.39%), Query Frame = 1

Query:  157 IGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            IG+GSFG    V      +G++   V+KE+ +  M   +  E  +E  +L+ ++H NIV++ +SF     Y I+ +YCEGGDL + I   K  G    E +I+ WF+Q+   L ++H RKILHRD+K  NIFL  D +V++GDFGI+R+LN T +LA T +GTPYY+SPE+ ++  YN   DIW+ G +LYEMC LKHAF   N+  +++ I+    P +  +YS  L+ +L  +  ++P  RP    IL+ PF+  +I
Sbjct:   10 IGEGSFGKAILVNS--KEDGRQY--VIKEIGISGMSTKERRESRKEVSVLANMSHPNIVQYKESFEGGCLY-IVMDYCEGGDLFKKINSQK--GVLFSEDQILDWFVQICLALKHVHGRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLN-TVELARTCIGTPYYLSPEICENKPYNN-KDIWALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSPELRSLLAQLFRRNPRERPSVSSILEKPFLSCRI 259

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000034147.1 (serine/threonine-protein kinase Nek5 [Source:NCBI gene;Acc:101162253])

HSP 1 Score: 200.675 bits (509), Expect = 6.070e-55
Identity = 101/268 (37.69%), Postives = 159/268 (59.33%), Query Frame = 1

Query:  133 NRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVK--IGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            N Y  L  IG+G+FG  + V+   G  G ++  V+K++N+  M   + E   +E  LLS++ H NIV F  SF  + +  I+ E+C+GGDL + I   +  G    E  I+  F+Q+  GL +IH +K+LHRD+K  NIFL    +K  +GDFGI+R+LN + DLA T +GTPYY+SPE+ +   YN  +D+WS G +LYE+C L+H F G +L +++  I       +P+ Y+  L+ ++  +   +P +RP    +L  PF++  I
Sbjct:    2 NDYEVLWQIGEGAFGKAFLVRSKTG--GGDTQCVIKQINLQKMSAKERESSRKEVTLLSRMRHPNIVSFISSFLEKGSLFIVMEFCDGGDLLKKINMQR--GVPFREEEILDLFVQICLGLKHIHDKKVLHRDIKCQNIFLTNGGMKAKLGDFGIARMLNNSMDLARTCVGTPYYLSPEICESRPYNNKTDVWSLGCVLYELCTLRHPFEGSSLRQLLGKICRGRYAPVPTRYTHELRLLVNQLFKVNPRDRPSISSVLQRPFLQKHI 265

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000027525.1 (NIMA related kinase 3 [Source:NCBI gene;Acc:101171427])

HSP 1 Score: 190.66 bits (483), Expect = 2.729e-53
Identity = 106/316 (33.54%), Postives = 172/316 (54.43%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILD----LPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLS-KSTGLNIITAASVEL 1065
            +Y  L  +G+GSFG    V+     E      V+KE+ +   ++ ++ +  +E  LLS++ H NIV F ++F + +  CI+ EYC GGDL Q I++ K +    E   I+RWF Q+  G  +IH +++LHRDLK  NIFL  D SVK+GDFG + +LN +   A  ++GTPYY++PE+  +  YN  SD+WS G +LYE+CAL+H F   +   +++ +     P +P +    L  +++ I   +P +RP    IL        ++S +    I+  ++          E + ++ FL  KS     +  A+VEL
Sbjct:    3 KYTQLKVVGEGSFGRAVLVQWISTQEKY----VVKEIQLPK-NESKLRDSRKEAILLSRMKHPNIVAFREAFEMTDLLCIVMEYCSGGDLLQRIQQQKATNFCTEN--ILRWFAQMCAGAQHIHDKRVLHRDLKSKNIFLTGDGSVKLGDFGSACVLNSSKAYAHAYVGTPYYVAPEIWDNKPYNNKSDVWSLGCVLYELCALQHPFQASSWKSLILKVCRGAYPPLPRHLPYELLHLMKQIFKTNPKDRPSVQTILTSHRVSKLLRSHLPSQAIEKAKDGRRPGRWNREEGEKVAQFLGDKSLQRTSVFGAAVEL 311

[Close]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000045610.1 (NIMA related kinase 3 [Source:NCBI gene;Acc:101171427])

HSP 1 Score: 190.66 bits (483), Expect = 2.729e-53
Identity = 106/316 (33.54%), Postives = 172/316 (54.43%), Query Frame = 1

Query:  136 RYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYD-SVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILD----LPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLS-KSTGLNIITAASVEL 1065
            +Y  L  +G+GSFG    V+     E      V+KE+ +   ++ ++ +  +E  LLS++ H NIV F ++F + +  CI+ EYC GGDL Q I++ K +    E   I+RWF Q+  G  +IH +++LHRDLK  NIFL  D SVK+GDFG + +LN +   A  ++GTPYY++PE+  +  YN  SD+WS G +LYE+CAL+H F   +   +++ +     P +P +    L  +++ I   +P +RP    IL        ++S +    I+  ++          E + ++ FL  KS     +  A+VEL
Sbjct:    3 KYTQLKVVGEGSFGRAVLVQWISTQEKY----VVKEIQLPK-NESKLRDSRKEAILLSRMKHPNIVAFREAFEMTDLLCIVMEYCSGGDLLQRIQQQKATNFCTEN--ILRWFAQMCAGAQHIHDKRVLHRDLKSKNIFLTGDGSVKLGDFGSACVLNSSKAYAHAYVGTPYYVAPEIWDNKPYNNKSDVWSLGCVLYELCALQHPFQASSWKSLILKVCRGAYPPLPRHLPYELLHLMKQIFKTNPKDRPSVQTILTSHRVSKLLRSHLPSQAIEKAKDGRRPGRWNREEGEKVAQFLGDKSLQRTSVFGAAVEL 311

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000057044.1 (SMESG000057044.1)

HSP 1 Score: 1236.09 bits (3197), Expect = 0.000e+0
Identity = 600/605 (99.17%), Postives = 601/605 (99.34%), Query Frame = 1

Query:   97 MSILQESTRHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSKSTGLNIITAASVELTPKQKILLKKSMEADKKAEEQREYIEKTHKSNVENRRKLKQDQFQSSLPFTNQRNASTRSSISEYDELNSSRNSGFNTFAGINKVEKENYNRLSKTEIIGKHFKLTPIEAFKNNDEEDDIYSRKTNFNQNGLFNTQYRNLKYDDSSNYNVAPYNPVNDPDNQDILFEYAPDFETDSDSSSNSVREKNGEDEIQMDLNFEAFQDNPETDPYGKNTKQKKINAMKKKCLEKVDEKTLEKAIRYMKENWRKKDYIIRLLKICKSDDVAMTVDQLFFLMLPINEIY 1911
            MSILQESTRHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSKSTGLNIITAASVELTPKQKILLKKSMEADKKA+EQREYIEKTHKSNVENRRKLKQDQFQSSLPFTNQRNASTRSSISEYDELN SRNSGFNTFAGINKVEKENYNRLSKTEIIGKHFKLTPIEAFKNNDEEDDIYSRKTNFNQNGLFNTQY NLKYDDSSNYNVAPYNPVNDPDNQD  FEYAPDFETDSDSSSNSVREKNGEDEIQMDLNFEAFQDNPETDPYGKNTKQKKINAMKKKCLEKVDEKTLEKAIRYMKENWRKKDYIIRLLKICKSDDVAMTVDQLFFLMLPINEIY
Sbjct:    1 MSILQESTRHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNESKDISNFLSKSTGLNIITAASVELTPKQKILLKKSMEADKKAKEQREYIEKTHKSNVENRRKLKQDQFQSSLPFTNQRNASTRSSISEYDELNCSRNSGFNTFAGINKVEKENYNRLSKTEIIGKHFKLTPIEAFKNNDEEDDIYSRKTNFNQNGLFNTQYTNLKYDDSSNYNVAPYNPVNDPDNQDTFFEYAPDFETDSDSSSNSVREKNGEDEIQMDLNFEAFQDNPETDPYGKNTKQKKINAMKKKCLEKVDEKTLEKAIRYMKENWRKKDYIIRLLKICKSDDVAMTVDQLFFLMLPINEIY 605

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000005635.1 (SMESG000005635.1)

HSP 1 Score: 204.142 bits (518), Expect = 5.056e-57
Identity = 111/264 (42.05%), Postives = 151/264 (57.20%), Query Frame = 1

Query:  139 YIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            Y F+  IG+GS+G V+ VK     +      VLK+++       ++E    E +LL  L H NIV++ DSF   N+  I   +CE GDL   +++  R GS L E +II W IQ+   L YIH+R ILHRDLK  NIFL    +KIGD GI++ L    D+A T +GTPYYMSPE+ +   YN  SDIWS G + YEM  LKHAF   N   +   IL    P +PS Y++ L  +++ +L K P+ RP   +IL   FI+  I
Sbjct:    8 YSFIKKIGQGSYGEVWLVKH---KDYDHKKFVLKKISFARSSDREMEAARLECQLLKSLEHPNIVQYKDSFEENNSLYIAMAFCESGDLYTRLKE--RKGSLLCEKQIIEWLIQITMALSYIHERNILHRDLKTQNIFLTKSIIKIGDLGIAKQLESKYDMAKTVIGTPYYMSPELFEKKPYNFKSDIWSLGCVTYEMATLKHAFNAKNYTALSYKILMGQTPDMPSKYNKELINLIQAMLNKSPEKRPSTGKILCNNFIRDHI 266

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000020466.1 (SMESG000020466.1)

HSP 1 Score: 196.823 bits (499), Expect = 7.083e-53
Identity = 108/264 (40.91%), Postives = 164/264 (62.12%), Query Frame = 1

Query:  148 LSGIGKGSFGTVYKVKDFRGPEGQESIK--VLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            L+ IG+G+FG  + V      E +   K  VLKE+ +  M + +  E  +E  LLSK+NH NIV +++SF     + I+ EYCEGGDL + I+   ++G   +E +++ +FIQ+   L +IH ++ILHRD+KP NIFL K +SVK+GDFGI++ ++ T  L  T +GTP+Y SPE+ +   YN  SDIWS G ILYE+C+L +AF G ++  + + I +     +PS +S  L+ +++ +  + PD RP    IL  PFI  KI
Sbjct:   10 LNKIGQGAFGIAWLV------ESKIDCKKYVLKEIGLYKMHEKERFEARKEVSLLSKMNHPNIVTYYNSFEEVGCFHILMEYCEGGDLYRKIKT--QNGVLFKEDQVLDYFIQICLALKHIHDQRILHRDIKPQNIFLTKNNSVKLGDFGIAKAMDSTTALTKTQVGTPFYFSPEICEGCPYNNKSDIWSLGCILYELCSLNYAFYGQDITILAMRIKKVNYKPVPSVFSAPLRALVDNMFRRRPDERPNINTILRKPFILKKI 265

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000020466.1 (SMESG000020466.1)

HSP 1 Score: 196.823 bits (499), Expect = 7.408e-53
Identity = 108/264 (40.91%), Postives = 164/264 (62.12%), Query Frame = 1

Query:  148 LSGIGKGSFGTVYKVKDFRGPEGQESIK--VLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            L+ IG+G+FG  + V      E +   K  VLKE+ +  M + +  E  +E  LLSK+NH NIV +++SF     + I+ EYCEGGDL + I+   ++G   +E +++ +FIQ+   L +IH ++ILHRD+KP NIFL K +SVK+GDFGI++ ++ T  L  T +GTP+Y SPE+ +   YN  SDIWS G ILYE+C+L +AF G ++  + + I +     +PS +S  L+ +++ +  + PD RP    IL  PFI  KI
Sbjct:   10 LNKIGQGAFGIAWLV------ESKIDCKKYVLKEIGLYKMHEKERFEARKEVSLLSKMNHPNIVTYYNSFEEVGCFHILMEYCEGGDLYRKIKT--QNGVLFKEDQVLDYFIQICLALKHIHDQRILHRDIKPQNIFLTKNNSVKLGDFGIAKAMDSTTALTKTQVGTPFYFSPEICEGCPYNNKSDIWSLGCILYELCSLNYAFYGQDITILAMRIKKVNYKPVPSVFSAPLRALVDNMFRRRPDERPNINTILRKPFILKKI 265

[Close]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000020466.1 (SMESG000020466.1)

HSP 1 Score: 196.823 bits (499), Expect = 7.606e-53
Identity = 108/264 (40.91%), Postives = 164/264 (62.12%), Query Frame = 1

Query:  148 LSGIGKGSFGTVYKVKDFRGPEGQESIK--VLKEVNVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEGGDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNNIFL-KYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTASDIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEVLECILVKDPDNRPKACEILDLPFIKSKI 930
            L+ IG+G+FG  + V      E +   K  VLKE+ +  M + +  E  +E  LLSK+NH NIV +++SF     + I+ EYCEGGDL + I+   ++G   +E +++ +FIQ+   L +IH ++ILHRD+KP NIFL K +SVK+GDFGI++ ++ T  L  T +GTP+Y SPE+ +   YN  SDIWS G ILYE+C+L +AF G ++  + + I +     +PS +S  L+ +++ +  + PD RP    IL  PFI  KI
Sbjct:   10 LNKIGQGAFGIAWLV------ESKIDCKKYVLKEIGLYKMHEKERFEARKEVSLLSKMNHPNIVTYYNSFEEVGCFHILMEYCEGGDLYRKIKT--QNGVLFKEDQVLDYFIQICLALKHIHDQRILHRDIKPQNIFLTKNNSVKLGDFGIAKAMDSTTALTKTQVGTPFYFSPEICEGCPYNNKSDIWSLGCILYELCSLNYAFYGQDITILAMRIKKVNYKPVPSVFSAPLRALVDNMFRRRPDERPNINTILRKPFILKKI 265

The following BLAST results are available for this feature:

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
BLAST of Protein kinase domain-containing protein vs. TrEMBL
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST

BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NEK11	1.174e-97	42.50	NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGN...	[more]
NEK11	1.174e-97	42.50	NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGN...	[more]
NEK11	2.845e-97	42.50	NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGN...	[more]
NEK11	6.311e-96	42.50	NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGN...	[more]
NEK11	1.039e-95	42.50	NIMA related kinase 11 [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nekl-3	3.845e-49	35.36	Serine/threonine-protein kinase nekl-3 [Source:Un...	[more]
nekl-3	3.845e-49	35.36	Serine/threonine-protein kinase nekl-3 [Source:Un...	[more]
nekl-1	4.346e-49	39.62	NEK (NEver in mitosis Kinase) Like [Source:UniPro...	[more]
nekl-1	5.599e-49	39.62	NEK (NEver in mitosis Kinase) Like [Source:UniPro...	[more]
nekl-2	2.747e-41	32.57	Serine/threonine-protein kinase nekl-2 [Source:Un...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nek2	2.881e-49	35.96	gene:FBgn0029970 transcript:FBtr0071142	[more]
niki	9.338e-44	38.80	gene:FBgn0045980 transcript:FBtr0084737	[more]
GckIII	6.890e-41	33.83	gene:FBgn0266465 transcript:FBtr0083399	[more]
Slik	1.772e-35	30.83	gene:FBgn0035001 transcript:FBtr0290019	[more]
Slik	1.916e-35	30.83	gene:FBgn0035001 transcript:FBtr0100470	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nek11	9.042e-85	41.71	NIMA-related kinase 11 [Source:ZFIN;Acc:ZDB-GENE-1...	[more]
nek1	1.079e-63	40.82	NIMA-related kinase 1 [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
nek4	3.113e-60	40.23	NIMA-related kinase 4 [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
nek4	3.146e-60	40.23	NIMA-related kinase 4 [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
nek12	2.315e-55	36.84	NIMA-related kinase 12 [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sult1c1	5.557e-95	43.21	sulfotransferase family, cytosolic, 1C, member 1 [...	[more]
ENSXETT00000013864.1	1.454e-85	39.90	serine/threonine-protein kinase Nek11-like [Source...	[more]
sez6l2	2.000e-60	38.06	seizure related 6 homolog like 2 [Source:Xenbase;A...	[more]
nek1	1.429e-59	41.57	NIMA-related kinase 1 [Source:NCBI gene;Acc:100036...	[more]
nek1	1.485e-59	41.57	NIMA-related kinase 1 [Source:NCBI gene;Acc:100036...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Nek11	8.487e-89	41.67	NIMA (never in mitosis gene a)-related expressed k...	[more]
Nek11	6.123e-88	40.22	NIMA (never in mitosis gene a)-related expressed k...	[more]
Nek1	7.149e-60	40.98	NIMA (never in mitosis gene a)-related expressed k...	[more]
Nek1	7.311e-60	40.98	NIMA (never in mitosis gene a)-related expressed k...	[more]
Nek1	7.755e-60	40.98	NIMA (never in mitosis gene a)-related expressed k...	[more]

BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8NG66\|NEK11_HUMAN	4.990e-95	42.50	Serine/threonine-protein kinase Nek11 OS=Homo sapi...	[more]
sp\|Q8WNU8\|NEK11_MACFA	2.373e-93	42.22	Serine/threonine-protein kinase Nek11 OS=Macaca fa...	[more]
sp\|Q8C0Q4\|NEK11_MOUSE	4.283e-87	40.22	Serine/threonine-protein kinase Nek11 OS=Mus muscu...	[more]
sp\|Q86I06\|NEK3_DICDI	1.569e-60	44.94	Probable serine/threonine-protein kinase nek3 OS=D...	[more]
sp\|P51954\|NEK1_MOUSE	5.114e-59	40.98	Serine/threonine-protein kinase Nek1 OS=Mus muscul...	[more]

BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8G9L5	2.149e-101	42.99	Protein kinase domain-containing protein OS=Macros...	[more]
A0A267F3B3	4.519e-101	42.99	Protein kinase domain-containing protein (Fragment...	[more]
A0A267F7N0	5.043e-101	42.99	Protein kinase domain-containing protein (Fragment...	[more]
A0A267G446	7.977e-100	42.52	Protein kinase domain-containing protein (Fragment...	[more]
A0A1S3JN97	3.898e-96	43.32	serine/threonine-protein kinase Nek11 OS=Lingula u...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nek1	7.684e-62	34.13	NIMA related kinase 1 [Source:NCBI gene;Acc:103028...	[more]
nek1	6.742e-61	34.97	NIMA related kinase 1 [Source:NCBI gene;Acc:103028...	[more]
nek4	7.509e-60	40.67	NIMA related kinase 4 [Source:NCBI gene;Acc:103043...	[more]
nek4	1.115e-59	40.67	NIMA related kinase 4 [Source:NCBI gene;Acc:103043...	[more]
ENSAMXT00000049860.1	1.134e-56	35.16	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000007414.1	3.887e-64	40.00	pep scaffold:Pmarinus_7.0:GL476981:230882:244405:1...	[more]
NEK9	3.384e-46	37.31	NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC...	[more]
nek2	3.376e-45	40.91	NIMA-related kinase 2 [Source:ZFIN;Acc:ZDB-GENE-04...	[more]
ENSPMAT00000000555.1	1.829e-39	37.91	pep scaffold:Pmarinus_7.0:GL477093:35206:42652:1 g...	[more]
STK36	1.115e-36	28.87	serine/threonine kinase 36 [Source:HGNC Symbol;Acc...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
KIN3	4.883e-37	29.25	Nonessential serine/threonine protein kinase; poss...	[more]
SPS1	6.586e-36	33.33	Putative protein serine/threonine kinase; localize...	[more]
STE20	5.281e-35	31.42	Cdc42p-activated signal transducing kinase; involv...	[more]
KIC1	1.589e-34	32.84	Protein kinase of the PAK/Ste20 family, required f...	[more]
CMK2	1.484e-33	32.35	Calmodulin-dependent protein kinase; may play a ro...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37069	1.386e-91	52.99	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49690	4.098e-64	40.67	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49822	5.840e-64	41.35	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49138	8.134e-60	40.66	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34646	5.978e-52	37.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nek4	2.452e-60	40.67	NIMA related kinase 4 [Source:NCBI gene;Acc:101169...	[more]
ENSORLT00000000545.2	1.904e-56	40.54	pep primary_assembly:ASM223467v1:4:1040495:1044496...	[more]
ENSORLT00000034147.1	6.070e-55	37.69	serine/threonine-protein kinase Nek5 [Source:NCBI ...	[more]
ENSORLT00000027525.1	2.729e-53	33.54	NIMA related kinase 3 [Source:NCBI gene;Acc:101171...	[more]
ENSORLT00000045610.1	2.729e-53	33.54	NIMA related kinase 3 [Source:NCBI gene;Acc:101171...	[more]

BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000057044.1	0.000e+0	99.17	SMESG000057044.1	[more]
SMESG000005635.1	5.056e-57	42.05	SMESG000005635.1	[more]
SMESG000020466.1	7.083e-53	40.91	SMESG000020466.1	[more]
SMESG000020466.1	7.408e-53	40.91	SMESG000020466.1	[more]
SMESG000020466.1	7.606e-53	40.91	SMESG000020466.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022545 ID=SMED30022545|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1948bp
TAATGAAGAAATTTTAATTTCTTTGCTGTTATATTTAATTATATTTTTAC
ATGATCATATTTGCATAATTTTTTTCATTTCCAAATAGCACTTAACATGT
CAATTCTGCAAGAAAGCACGCGACACTGGGGCAACAGATATATATTTTTG
AGTGGAATTGGTAAAGGTTCATTTGGAACTGTTTATAAAGTCAAAGATTT
TCGAGGTCCGGAAGGGCAAGAAAGTATCAAAGTACTGAAAGAAGTGAATG
TTGATACAATGGACCAAGATCAAATTGAAGAATGTACAAGAGAAGGAAAA
TTGTTATCGAAATTGAATCATTCAAACATTGTTAAATTTTTTGATTCTTT
CCGCTTAGAGAATAACTATTGCATAATAACTGAATACTGCGAAGGCGGAG
ATTTAAAGCAAGTAATAGAGAAAACCAAACGATCAGGAAGTCATCTTGAA
GAGCTGCGAATTATTCGCTGGTTTATTCAAGTGATTGAAGGGTTGGATTA
TATCCATAAACGGAAAATCCTTCATCGAGATCTCAAACCGAATAACATTT
TCCTCAAATACGATTCGGTAAAGATAGGCGATTTTGGAATATCGAGAATT
CTCAATTTTACTAATGACCTGGCATCGACATTTCTCGGCACGCCTTACTA
TATGAGTCCTGAAGTTTTGAAGCATGACGGATACAACACAGCTTCCGATA
TCTGGTCGAGTGGAGTTATTTTATATGAAATGTGCGCGTTAAAGCACGCG
TTTATTGGGGATAATTTAATGAGAGTTATGGTGACAATTCTAGAAAGTCC
ATGTCCTCGAATTCCTTCAAATTATAGCGAAAATCTACAAGAGGTCCTTG
AATGTATTTTAGTCAAAGATCCAGACAACAGACCCAAGGCATGTGAAATT
TTAGATTTGCCATTTATCAAATCAAAGATTCGAGATCCCTGGATAGACAT
AGTGGAAAACGACGACATGAGTGAAACACTGGTGAATAATGAATCAAAGG
ATATTTCAAACTTTTTGTCTAAATCGACAGGTTTGAACATAATTACTGCT
GCCTCAGTCGAACTTACGCCAAAGCAGAAAATTCTACTGAAAAAGTCAAT
GGAAGCCGACAAAAAGGCAGAAGAGCAACGAGAATACATTGAAAAAACTC
ATAAATCAAATGTAGAAAACCGGCGAAAGCTGAAACAAGATCAGTTCCAA
TCATCTCTGCCTTTCACCAACCAAAGAAATGCGTCAACAAGATCTTCGAT
TTCTGAATATGATGAATTAAATTCTTCTAGAAATTCAGGATTCAACACAT
TTGCGGGAATAAATAAAGTTGAAAAAGAGAATTACAATCGGCTGTCTAAA
ACAGAAATAATTGGAAAACATTTCAAACTCACCCCAATTGAAGCCTTTAA
GAATAATGACGAAGAAGACGATATTTATAGTAGGAAGACAAATTTTAATC
AAAACGGATTGTTCAATACTCAATATAGAAATTTGAAATATGACGATTCA
TCTAATTATAACGTGGCTCCCTATAACCCAGTTAACGACCCCGATAATCA
AGATATCCTTTTTGAATATGCTCCTGATTTCGAAACGGACTCCGACAGTA
GCTCAAATTCCGTTAGAGAAAAAAATGGCGAGGATGAGATACAAATGGAT
CTAAACTTCGAAGCATTTCAAGATAATCCCGAAACTGATCCATATGGGAA
GAATACAAAACAGAAAAAAATTAATGCAATGAAAAAAAAATGCCTTGAAA
AGGTCGACGAGAAAACTCTTGAAAAAGCTATAAGATATATGAAAGAAAAT
TGGAGGAAAAAAGATTATATAATCAGACTTTTAAAGATCTGTAAGTCTGA
TGATGTTGCTATGACAGTGGATCAACTATTCTTTTTGATGCTTCCGATAA
ACGAAATATATTAGAGAATTTTGCTTGTTGTATAGATATTATATTAAA

protein sequence of SMED30022545-orf-1

>SMED30022545-orf-1 ID=SMED30022545-orf-1|Name=SMED30022545-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=606bp
MSILQESTRHWGNRYIFLSGIGKGSFGTVYKVKDFRGPEGQESIKVLKEV
NVDTMDQDQIEECTREGKLLSKLNHSNIVKFFDSFRLENNYCIITEYCEG
GDLKQVIEKTKRSGSHLEELRIIRWFIQVIEGLDYIHKRKILHRDLKPNN
IFLKYDSVKIGDFGISRILNFTNDLASTFLGTPYYMSPEVLKHDGYNTAS
DIWSSGVILYEMCALKHAFIGDNLMRVMVTILESPCPRIPSNYSENLQEV
LECILVKDPDNRPKACEILDLPFIKSKIRDPWIDIVENDDMSETLVNNES
KDISNFLSKSTGLNIITAASVELTPKQKILLKKSMEADKKAEEQREYIEK
THKSNVENRRKLKQDQFQSSLPFTNQRNASTRSSISEYDELNSSRNSGFN
TFAGINKVEKENYNRLSKTEIIGKHFKLTPIEAFKNNDEEDDIYSRKTNF
NQNGLFNTQYRNLKYDDSSNYNVAPYNPVNDPDNQDILFEYAPDFETDSD
SSSNSVREKNGEDEIQMDLNFEAFQDNPETDPYGKNTKQKKINAMKKKCL
EKVDEKTLEKAIRYMKENWRKKDYIIRLLKICKSDDVAMTVDQLFFLMLP
INEIY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000034	epidermis
PLANA:0000054	dorsal region of the epidermis
PLANA:0000418	head
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0046872	metal ion binding
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0016310	phosphorylation
GO:0016572	histone phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0031573	intra-S DNA damage checkpoint
GO:0035556	intracellular signal transduction
GO:0044772	mitotic cell cycle phase transition
GO:1901990	regulation of mitotic cell cycle phase transition

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 15..274 e-value: 3.3E-84 score: 295.8
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 18..274 e-value: 9.0E-63 score: 212.1
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 15..274 score: 48.654
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 6..372 e-value: 6.3E-80 score: 270.9
None	No IPR available	PIRSF	PIRSF000615	TyrPK_CSF1-R	coord: 16..116 e-value: 0.011 score: 11.4 coord: 293..400 e-value: 260.0 score: -3.0 coord: 104..218 e-value: 1.1E-12 score: 44.5
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 365..382
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 351..382
None	No IPR available	PANTHER	PTHR43671	FAMILY NOT NAMED	coord: 12..596
None	No IPR available	PANTHER	PTHR43671:SF24	SERINE/THREONINE-PROTEIN KINASE NEK11	coord: 12..596
None	No IPR available	CDD	cd08215	STKc_Nek	coord: 14..274 e-value: 8.82203E-118 score: 348.298
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 141..153
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 12..275