Centrin-3

Overview


Name	Centrin-3
Smed ID	SMED30022522
Length (bp)	739

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Centrin-3 (SMED30022522) t-SNE clustered cells

Violin plots show distribution of expression levels for Centrin-3 (SMED30022522) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Centrin-3 (SMED30022522) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Centrin-3 (SMED30022522) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022522

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 8

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30022522	h1SMcG0003800	SmedASXL_005568	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30022522	h1SMcG0003800	Contig41289	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30022522	h1SMcG0003800	Contig41289	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
pharynx	SMED30022522	h1SMcG0003800	dd_Smed_v4_11582_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30022522	h1SMcG0003800	dd_Smed_v4_11582_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30022522	h1SMcG0003800	dd_Smed_v6_11582_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
pigment cell	SMED30022522	h1SMcG0003800	SMED30022522	smed_20140614	PMID:22884275 Lapan et al., 2012
epidermis	SMED30022522	h1SMcG0003800	dd_Smed_v4_11582_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Centrin-3 vs. Ensembl Human
Match: CETN3 (centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868])

HSP 1 Score: 200.675 bits (509), Expect = 6.873e-65
Identity = 100/165 (60.61%), Postives = 133/165 (80.61%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG IN EEF+AIM G+I
Sbjct:    4 ALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI 167

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BLAST of Centrin-3 vs. Ensembl Human
Match: CETN3 (centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868])

HSP 1 Score: 186.808 bits (473), Expect = 4.452e-59
Identity = 100/189 (52.91%), Postives = 133/189 (70.37%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSI------------------------NMEEFMAIMNGEI 575
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG I                        N EEF+AIM G+I
Sbjct:    4 ALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEILKNILLLPIWSRCLSLNREFFSEVNQEEFIAIMTGDI 191

[Close]

BLAST of Centrin-3 vs. Ensembl Human
Match: CETN3 (centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868])

HSP 1 Score: 179.489 bits (454), Expect = 1.207e-56
Identity = 90/150 (60.00%), Postives = 121/150 (80.67%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDG 530
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG
Sbjct:    4 ALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDG 152

[Close]

BLAST of Centrin-3 vs. Ensembl Human
Match: CETN1 (centrin 1 [Source:HGNC Symbol;Acc:HGNC:1866])

HSP 1 Score: 148.288 bits (373), Expect = 3.271e-44
Identity = 72/143 (50.35%), Postives = 108/143 (75.52%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT DQ+ E+ EAF+LFD D  G +   E KV++RALGFE +K ++ K++S+ + ++   KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA ELGE LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:   25 LTEDQKQEVREAFDLFDVDGSGTIDAKELKVAMRALGFEPRKEEMKKMISEVD-REGTGKISFNDFLAVMTQKMSEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGENLTDEELQEMIDEADRDGDGEVNEEEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Human
Match: CETN2 (centrin 2 [Source:HGNC Symbol;Acc:HGNC:1867])

HSP 1 Score: 147.517 bits (371), Expect = 5.681e-44
Identity = 74/158 (46.84%), Postives = 115/158 (72.78%), Query Frame = 3

Query:   90 MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            M +S  + +     +LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K++S+ + K+   K+ F DF  ++++ + E+D   E+++AFKLFDDDE+GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG ++ +EF+ IM
Sbjct:   10 MASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRALGFEPKKEEIKKMISEID-KEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Celegans
Match: cmd-1 (Calmodulin [Source:UniProtKB/Swiss-Prot;Acc:O16305])

HSP 1 Score: 88.1965 bits (217), Expect = 9.147e-22
Identity = 53/145 (36.55%), Postives = 82/145 (56.55%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMN 566
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M 
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMT 147

[Close]

BLAST of Centrin-3 vs. Ensembl Celegans
Match: cal-1 (Calmodulin-like protein [Source:UniProtKB/Swiss-Prot;Acc:P04630])

HSP 1 Score: 87.4261 bits (215), Expect = 3.735e-21
Identity = 50/169 (29.59%), Postives = 103/169 (60.95%), Query Frame = 3

Query:   69 LHCQTLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIR-AFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            +  + + + ++L +  +  +++LT ++ +E  EAF +FD D +G +S  E  +++R+LG    + ++ +++++ +I D   +I+F +F  ++  M+ E D  +EMIR AF++FD D +G I+ +  +     +G   ++ E+  MI+E D DGDG I+ EEF+ +M+ +
Sbjct:   15 IRAERMAIPSNLMQFSEDIIKQLTPEEIDEFREAFMMFDKDGNGTISTKELGIAMRSLGQNPTEQEILEMINEVDI-DGNGQIEFPEFCVMMKRMMKETD--SEMIREAFRVFDKDGNGVITAQEFRYFMVHMGMQFSEEEVDEMIKEVDVDGDGEIDYEEFVKMMSNQ 180

[Close]

BLAST of Centrin-3 vs. Ensembl Celegans
Match: cal-1 (Calmodulin-like protein [Source:UniProtKB/Swiss-Prot;Acc:P04630])

HSP 1 Score: 86.2705 bits (212), Expect = 6.241e-21
Identity = 50/164 (30.49%), Postives = 101/164 (61.59%), Query Frame = 3

Query:   84 LRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIR-AFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            + + ++L +  +  +++LT ++ +E  EAF +FD D +G +S  E  +++R+LG    + ++ +++++ +I D   +I+F +F  ++  M+ E D  +EMIR AF++FD D +G I+ +  +     +G   ++ E+  MI+E D DGDG I+ EEF+ +M+ +
Sbjct:    1 MAIPSNLMQFSEDIIKQLTPEEIDEFREAFMMFDKDGNGTISTKELGIAMRSLGQNPTEQEILEMINEVDI-DGNGQIEFPEFCVMMKRMMKETD--SEMIREAFRVFDKDGNGVITAQEFRYFMVHMGMQFSEEEVDEMIKEVDVDGDGEIDYEEFVKMMSNQ 161

[Close]

BLAST of Centrin-3 vs. Ensembl Celegans
Match: tnc-2 (Troponin C, isoform 2 [Source:UniProtKB/Swiss-Prot;Acc:Q09665])

HSP 1 Score: 77.7962 bits (190), Expect = 1.180e-17
Identity = 43/154 (27.92%), Postives = 89/154 (57.79%), Query Frame = 3

Query:  123 TLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDP----TTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
             L KL+ DQ  +  + F +FD +  G +   +    LR +G   ++ D+ +++ +F+  D + +I+F++F  +V+  ++  +       E+  AF+L+D + +G I+  +L+ + R L + +++ E+  MI E D DG G+++ +EFM +M+GE
Sbjct:    8 ALEKLSADQIEQFRKYFNMFDKEGKGYIRATQVGQILRTMGQAFEERDLKQLIKEFD-ADGSGEIEFEEFAAMVANFVVNNENDEGLEEELREAFRLYDKEGNGYINVSDLRDILRALDDNVSEEELDEMIAEIDADGSGTVDFDEFMEMMSGE 160

[Close]

BLAST of Centrin-3 vs. Ensembl Celegans
Match: cal-2 (CALmodulin related genes; Calmodulin-like protein [Source:UniProtKB/TrEMBL;Acc:G5EEG0])

HSP 1 Score: 75.0998 bits (183), Expect = 1.287e-16
Identity = 47/135 (34.81%), Postives = 78/135 (57.78%), Query Frame = 3

Query:  156 EINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIR-AFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMA 557
            E   AF LFD D +G +S  E  V++R+LG    + ++  ++++ +I D +  I F +F +++  M  E D  +EMIR AF++FD D +G I+    +     +G+  +D E+  +I E D DGDG I+ EEF +
Sbjct:   36 EYKAAFRLFDKDGNGSISSKELGVAMRSLGQNPTEQELLDMVNEVDI-DGSGTIDFGEFCQMMKRMNKEND--SEMIREAFRVFDRDGNGFITADEFRYFMTHMGDQFSDQEVDEIIAEIDIDGDGQIDYEEFAS 167

HSP 2 Score: 51.9878 bits (123), Expect = 4.132e-8
Identity = 33/85 (38.82%), Postives = 44/85 (51.76%), Query Frame = 3

Query:  309 PKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            P   FD  NE   E I+E         AF+LFD D +G IS + L    R LG+  T+ E+  M+ E D DG G+I+  EF  +M
Sbjct:   22 PVSGFDGLNE---EEIMEYKA------AFRLFDKDGNGSISSKELGVAMRSLGQNPTEQELLDMVNEVDIDGSGTIDFGEFCQMM 97

[Close]

BLAST of Centrin-3 vs. Ensembl Fly
Match: CG17493 (gene:FBgn0040010 transcript:FBtr0332630)

HSP 1 Score: 144.05 bits (362), Expect = 8.710e-43
Identity = 76/163 (46.63%), Postives = 117/163 (71.78%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            T+  +    + +KK+  K  L+  Q+ +I EAF+LFD++  G +   E KV++RALGFE KK ++ +++SD + KD + +I F+ F ++++  + E+D   E+++AF+LFDDD++GKIS+RNLK+VARELGETLTD E+R MI+E D D DG +N EEF+ IM
Sbjct:   15 TVPAKRGTQQGRKKSGPKFELSEAQKCDIKEAFDLFDNEGTGYIEVKELKVAIRALGFEPKKEEIKRMISDID-KDCSGRIAFNVFLQLMTIKMAEKDTKEEILKAFRLFDDDDTGKISFRNLKRVARELGETLTDEELREMIDEADLDNDGEVNQEEFLRIM 176

[Close]

BLAST of Centrin-3 vs. Ensembl Fly
Match: CG17493 (gene:FBgn0040010 transcript:FBtr0332632)

HSP 1 Score: 144.05 bits (362), Expect = 8.710e-43
Identity = 76/163 (46.63%), Postives = 117/163 (71.78%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            T+  +    + +KK+  K  L+  Q+ +I EAF+LFD++  G +   E KV++RALGFE KK ++ +++SD + KD + +I F+ F ++++  + E+D   E+++AF+LFDDD++GKIS+RNLK+VARELGETLTD E+R MI+E D D DG +N EEF+ IM
Sbjct:   15 TVPAKRGTQQGRKKSGPKFELSEAQKCDIKEAFDLFDNEGTGYIEVKELKVAIRALGFEPKKEEIKRMISDID-KDCSGRIAFNVFLQLMTIKMAEKDTKEEILKAFRLFDDDDTGKISFRNLKRVARELGETLTDEELREMIDEADLDNDGEVNQEEFLRIM 176

[Close]

BLAST of Centrin-3 vs. Ensembl Fly
Match: CG17493 (gene:FBgn0040010 transcript:FBtr0332631)

HSP 1 Score: 144.05 bits (362), Expect = 8.710e-43
Identity = 76/163 (46.63%), Postives = 117/163 (71.78%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            T+  +    + +KK+  K  L+  Q+ +I EAF+LFD++  G +   E KV++RALGFE KK ++ +++SD + KD + +I F+ F ++++  + E+D   E+++AF+LFDDD++GKIS+RNLK+VARELGETLTD E+R MI+E D D DG +N EEF+ IM
Sbjct:   15 TVPAKRGTQQGRKKSGPKFELSEAQKCDIKEAFDLFDNEGTGYIEVKELKVAIRALGFEPKKEEIKRMISDID-KDCSGRIAFNVFLQLMTIKMAEKDTKEEILKAFRLFDDDDTGKISFRNLKRVARELGETLTDEELREMIDEADLDNDGEVNQEEFLRIM 176

[Close]

BLAST of Centrin-3 vs. Ensembl Fly
Match: CG31802 (gene:FBgn0051802 transcript:FBtr0081058)

HSP 1 Score: 121.709 bits (304), Expect = 3.920e-34
Identity = 60/143 (41.96%), Postives = 99/143 (69.23%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            L++ Q+ +I +AF+LFD+   G +   E +V++RALGFE KK D+ +++ + + KD   +I F+DF  ++   + E+D   +M++AF  FDDD +G IS+ NLK+VA+ELGE LTD E++ MI+E +  GDG ++ EEF+ ++
Sbjct:   39 LSLSQKVDIKKAFDLFDTQCTGFIETKELRVAIRALGFEPKKEDIKRMMDEID-KDKTGRIAFNDFLYLMRLKMAEKDSNQDMMKAFSFFDDDRTGGISFLNLKRVAKELGEQLTDEELQEMIDEANVSGDGEVSKEEFLNLI 180

[Close]

BLAST of Centrin-3 vs. Ensembl Fly
Match: Cam (gene:FBgn0000253 transcript:FBtr0304964)

HSP 1 Score: 88.1965 bits (217), Expect = 1.276e-21
Identity = 53/145 (36.55%), Postives = 82/145 (56.55%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMN 566
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M 
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMT 147

[Close]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Match: cetn3 (centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152])

HSP 1 Score: 195.667 bits (496), Expect = 3.460e-63
Identity = 97/164 (59.15%), Postives = 134/164 (81.71%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            +LR E + +K+K+K  R+LT +Q++EI EAFELFD+DKD  +  +E KV++RALGFEVKK DV KIL D++ ++   KI F+DF E+V++MILERDP  E+++AFKLFDDDE+GKIS RNL++VARELGE ++D ++RAMI+EFD DGDG IN +EF++IM G+
Sbjct:    4 SLRTELTADKSKRKKRRELTDEQKDEIKEAFELFDTDKDKEIDYHELKVAMRALGFEVKKVDVLKILKDYD-REGTGKISFEDFREVVTDMILERDPKEEILKAFKLFDDDETGKISLRNLRRVARELGEDMSDEDLRAMIDEFDTDGDGEINQDEFISIMTGD 166

[Close]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Match: cetn3 (centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152])

HSP 1 Score: 192.971 bits (489), Expect = 4.025e-62
Identity = 96/163 (58.90%), Postives = 132/163 (80.98%), Query Frame = 3

Query:   84 LRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
             R E + +K+K+K  R+LT +Q++EI EAFELFD+DKD  +  +E KV++RALGFEVKK DV KIL D++ ++   KI F+DF E+V++MILERDP  E+++AFKLFDDDE+GKIS RNL++VARELGE ++D ++RAMI+EFD DGDG IN +EF++IM G+
Sbjct:    1 FRTELTADKSKRKKRRELTDEQKDEIKEAFELFDTDKDKEIDYHELKVAMRALGFEVKKVDVLKILKDYD-REGTGKISFEDFREVVTDMILERDPKEEILKAFKLFDDDETGKISLRNLRRVARELGEDMSDEDLRAMIDEFDTDGDGEINQDEFISIMTGD 162

[Close]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Match: cetn2 (centrin, EF-hand protein, 2 [Source:ZFIN;Acc:ZDB-GENE-091118-94])

HSP 1 Score: 153.68 bits (387), Expect = 1.324e-46
Identity = 74/143 (51.75%), Postives = 109/143 (76.22%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ EI EAFELFD+D  G +   E KV++RALGFE KK ++ K++++ + K+   KI F DF  ++++ + E+D   E+++AF+LFDDDE+GKIS+RNLK+VA+ELGE LTD E++ MI+E D+DGDG +N +EF+ IM
Sbjct:   25 LTEEQKQEIREAFELFDTDGSGYIEVKELKVAMRALGFEPKKEEIKKMIAEVD-KEATGKISFTDFLSVMTQKMAEKDSKEEILKAFRLFDDDETGKISFRNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNQQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Match: cetn4 (centrin 4 [Source:ZFIN;Acc:ZDB-GENE-030826-21])

HSP 1 Score: 146.362 bits (368), Expect = 9.593e-44
Identity = 76/156 (48.72%), Postives = 115/156 (73.72%), Query Frame = 3

Query:   99 SLNKAKKKTLR-KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            S N+ KK   + +LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++D + K+ +  I F DF  ++++ + E+D   E+++AF+LFDDD +GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN +EF+ IM
Sbjct:   11 SANQRKKAGPKPELTEEQKQEIKEAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEIKKMIADID-KEGSGVIGFSDFLSMMTQKMSEKDSKEEILKAFRLFDDDCTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIM 165

[Close]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Match: calm2a (calmodulin 2a (phosphorylase kinase, delta) [Source:ZFIN;Acc:ZDB-GENE-030804-3])

HSP 1 Score: 88.5817 bits (218), Expect = 9.791e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Xenopus
Match: rab38 (RAB38, member RAS oncogene family [Source:Xenbase;Acc:XB-GENE-480756])

HSP 1 Score: 201.445 bits (511), Expect = 3.067e-65
Identity = 99/165 (60.00%), Postives = 134/165 (81.21%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             +R + +++K KKK  R+LT +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++  +   KI FDDFNE+V+++IL+RDP  E+++AFKLFDDD+SGKIS RNL++VARELGE +TD E+RAMIEEFDKDGDG IN EEF++IM G++
Sbjct:    4 AVRTDLAVDKTKKKKRRELTEEQKQEIKDAFELFDTDKDKAIDYHELKVAMRALGFDVKKADVLKILKDYD-GETTGKITFDDFNEVVTDLILDRDPQEEILKAFKLFDDDDSGKISLRNLRRVARELGENMTDEELRAMIEEFDKDGDGEINQEEFLSIMTGDL 167

[Close]

BLAST of Centrin-3 vs. Ensembl Xenopus
Match: cetn1 (centrin 1 [Source:NCBI gene;Acc:549903])

HSP 1 Score: 149.058 bits (375), Expect = 1.132e-44
Identity = 76/157 (48.41%), Postives = 114/157 (72.61%), Query Frame = 3

Query:   99 SLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
             +   +KK + K  LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++D + K+   KI F DF   +++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG +N +EF+ IM
Sbjct:   11 GVTTQRKKPVPKPELTEEQKQEIREAFDLFDTDGAGTIDVKELKVAMRALGFEPKKEEIKKMIADID-KEGTGKISFGDFMSAMTQKMAEKDSKEEIMKAFRLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Xenopus
Match: cetn1 (centrin 1 [Source:NCBI gene;Acc:549903])

HSP 1 Score: 148.673 bits (374), Expect = 1.156e-44
Identity = 73/143 (51.05%), Postives = 108/143 (75.52%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++D + K+   KI F DF   +++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG +N +EF+ IM
Sbjct:   10 LTEEQKQEIREAFDLFDTDGAGTIDVKELKVAMRALGFEPKKEEIKKMIADID-KEGTGKISFGDFMSAMTQKMAEKDSKEEIMKAFRLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIM 151

[Close]

BLAST of Centrin-3 vs. Ensembl Xenopus
Match: dtl (denticleless E3 ubiquitin protein ligase homolog [Source:Xenbase;Acc:XB-GENE-985623])

HSP 1 Score: 147.902 bits (372), Expect = 3.772e-44
Identity = 75/143 (52.45%), Postives = 109/143 (76.22%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ KI+SD + KD +  I F+DF  ++++ + E+D   E+++AF+LFDDD +GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN +EF+ IM
Sbjct:   24 LTEEQKQEIREAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEMKKIISDTD-KDGSGIIDFEDFLSLMTQKMSEKDSKEEIMKAFRLFDDDNTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIM 165

[Close]

BLAST of Centrin-3 vs. Ensembl Xenopus
Match: dtl (denticleless E3 ubiquitin protein ligase homolog [Source:Xenbase;Acc:XB-GENE-985623])

HSP 1 Score: 147.517 bits (371), Expect = 5.150e-44
Identity = 75/143 (52.45%), Postives = 109/143 (76.22%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ KI+SD + KD +  I F+DF  ++++ + E+D   E+++AF+LFDDD +GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN +EF+ IM
Sbjct:   25 LTEEQKQEIREAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEMKKIISDTD-KDGSGIIDFEDFLSLMTQKMSEKDSKEEIMKAFRLFDDDNTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Mouse
Match: Cetn3 (centrin 3 [Source:MGI Symbol;Acc:MGI:1097706])

HSP 1 Score: 200.29 bits (508), Expect = 6.403e-65
Identity = 100/165 (60.61%), Postives = 133/165 (80.61%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG IN EEF+AIM G+I
Sbjct:    4 ALRGELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDQAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI 167

[Close]

BLAST of Centrin-3 vs. Ensembl Mouse
Match: Cetn3 (centrin 3 [Source:MGI Symbol;Acc:MGI:1097706])

HSP 1 Score: 163.31 bits (412), Expect = 1.005e-50
Identity = 81/125 (64.80%), Postives = 105/125 (84.00%), Query Frame = 3

Query:  156 EINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDG 530
            EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG
Sbjct:    2 EIKDAFELFDTDKDQAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDG 125

[Close]

BLAST of Centrin-3 vs. Ensembl Mouse
Match: Cetn1 (centrin 1 [Source:MGI Symbol;Acc:MGI:1347086])

HSP 1 Score: 152.525 bits (384), Expect = 3.873e-46
Identity = 78/166 (46.99%), Postives = 119/166 (71.69%), Query Frame = 3

Query:   75 CQTLRMENSLNKAKKKTL---RKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
              T R  N  + + K+ +    +LT DQ+ E+ EAF+LFDSD  G +   E KV++RALGFE +K ++ K++S+ + K+   KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA ELGE+LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:    2 ASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVD-KEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIM 166

[Close]

Query:   75 CQTLRMENSLNKAKKKTL---RKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
              T R  N  + + K+ +    +LT DQ+ E+ EAF+LFDSD  G +   E KV++RALGFE +K ++ K++S+ + K+   KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA ELGE+LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:    2 ASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVD-KEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIM 166

[Close]

Query:   75 CQTLRMENSLNKAKKKTL---RKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
              T R  N  + + K+ +    +LT DQ+ E+ EAF+LFDSD  G +   E KV++RALGFE +K ++ K++S+ + K+   KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA ELGE+LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:    2 ASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVD-KEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIM 166

[Close]

BLAST of Centrin-3 vs. UniProt/SwissProt
Match: sp|O15182|CETN3_HUMAN (Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2)

HSP 1 Score: 200.675 bits (509), Expect = 3.300e-64
Identity = 100/165 (60.61%), Postives = 133/165 (80.61%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG IN EEF+AIM G+I
Sbjct:    4 ALRSELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDEAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI 167

[Close]

BLAST of Centrin-3 vs. UniProt/SwissProt
Match: sp|O35648|CETN3_MOUSE (Centrin-3 OS=Mus musculus OX=10090 GN=Cetn3 PE=1 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 4.479e-64
Identity = 100/165 (60.61%), Postives = 133/165 (80.61%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             LR E  ++K K+K  R+L+ +Q+ EI +AFELFD+DKD  +  +E KV++RALGF+VKK DV KIL D++ ++   KI F+DFNE+V++ ILERDP  E+++AFKLFDDD+SGKIS RNL++VARELGE ++D E+RAMIEEFDKDGDG IN EEF+AIM G+I
Sbjct:    4 ALRGELVVDKTKRKKRRELSEEQKQEIKDAFELFDTDKDQAIDYHELKVAMRALGFDVKKADVLKILKDYD-REATGKITFEDFNEVVTDWILERDPHEEILKAFKLFDDDDSGKISLRNLRRVARELGENMSDEELRAMIEEFDKDGDGEINQEEFIAIMTGDI 167

[Close]

BLAST of Centrin-3 vs. UniProt/SwissProt
Match: sp|Q24956|CATR_GIAIN (Caltractin OS=Giardia intestinalis OX=5741 GN=CAL PE=3 SV=1)

HSP 1 Score: 155.221 bits (391), Expect = 2.672e-46
Identity = 73/155 (47.10%), Postives = 120/155 (77.42%), Query Frame = 3

Query:   99 SLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            S  K ++KT  +++ + ++EI EAF+LFD+D+ G +  +E KV++RALGF+VKK ++ +I+++++ +D   +I F DF E++ E I  RDPT E+++AF+LFDDD +G+IS +NL++VA+EL E ++D E+ AMI+EFD+DGDG I+ E+F+AI+
Sbjct:   16 STGKPRRKTRAEVSEEMKHEIREAFDLFDADRSGRIDFHELKVAMRALGFDVKKEEIQRIMNEYD-RDQLGEITFQDFEEVMIEKISNRDPTEEILKAFRLFDDDATGRISLKNLRRVAKELSENISDEELLAMIQEFDRDGDGEIDEEDFIAIL 169

[Close]

BLAST of Centrin-3 vs. UniProt/SwissProt
Match: sp|P41209|CETN1_MOUSE (Centrin-1 OS=Mus musculus OX=10090 GN=Cetn1 PE=1 SV=1)

HSP 1 Score: 152.525 bits (384), Expect = 2.709e-45
Identity = 78/166 (46.99%), Postives = 119/166 (71.69%), Query Frame = 3

Query:   75 CQTLRMENSLNKAKKKTL---RKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
              T R  N  + + K+ +    +LT DQ+ E+ EAF+LFDSD  G +   E KV++RALGFE +K ++ K++S+ + K+   KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA ELGE+LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:    2 ASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDGSGTIDVKELKVAMRALGFEPRKEEMKKMISEVD-KEATGKISFNDFLAVMTQKMAEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEEEFLKIM 166

[Close]

BLAST of Centrin-3 vs. UniProt/SwissProt
Match: sp|O74435|CDC31_SCHPO (Cell division control protein 31 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cdc31 PE=1 SV=1)

HSP 1 Score: 152.525 bits (384), Expect = 2.834e-45
Identity = 78/144 (54.17%), Postives = 108/144 (75.00%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            ++T +QR +INEAF+LFDSDKD  +  +E + ++RALGF  +K +V KIL DF+ K     ++ +DF  +++E I+ERDP  E+ RAF+LFDDDE+GKIS RNL++VA+EL E + D E+ AMIEEFD D DG IN +EF+AIM
Sbjct:   30 EITEEQRQDINEAFKLFDSDKDNAIDYHELRAAMRALGFNAEKSEVLKILRDFD-KTGKGYLQMEDFVRVMTEKIVERDPLEEIKRAFELFDDDETGKISLRNLRRVAKELNENIDDQELEAMIEEFDLDQDGEINEQEFIAIM 172

HSP 2 Score: 48.521 bits (114), Expect = 8.222e-6
Identity = 24/62 (38.71%), Postives = 35/62 (56.45%), Query Frame = 3

Query:  390 AFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            AFKLFD D+   I Y  L+   R LG      E+  ++ +FDK G G + ME+F+ +M  +I
Sbjct:   42 AFKLFDSDKDNAIDYHELRAAMRALGFNAEKSEVLKILRDFDKTGKGYLQMEDFVRVMTEKI 103

[Close]

BLAST of Centrin-3 vs. TrEMBL
Match: A0A4E0RN29 (Centrin EF-hand protein 3 OS=Fasciola hepatica OX=6192 GN=D915_001791 PE=4 SV=1)

HSP 1 Score: 227.254 bits (578), Expect = 2.804e-72
Identity = 109/160 (68.12%), Postives = 140/160 (87.50%), Query Frame = 3

Query:   96 NSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
             S +  +++  R+LT +Q+ EI EAF+LFD D+D L+S YEFKV+LRALGFE KK +V ++L D+NI++D+ K+KFD+FNEIV++MIL+RDPTTE+IRAFKLFDDD+SGKI+YRNLKKVARELGETLTD E+RAMIEEFD+DGDG+IN+EEFMA+M  EI
Sbjct:    2 QSPSNIRRRKRRELTPEQKQEIVEAFDLFDIDRDHLISFYEFKVALRALGFEFKKQEVLQVLEDYNIREDSGKLKFDEFNEIVADMILDRDPTTEIIRAFKLFDDDDSGKITYRNLKKVARELGETLTDQELRAMIEEFDRDGDGAINLEEFMALMTKEI 161

[Close]

BLAST of Centrin-3 vs. TrEMBL
Match: Q5DG25 (Centrin-3 OS=Schistosoma japonicum OX=6182 GN=EWB00_001301 PE=2 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 1.331e-68
Identity = 103/158 (65.19%), Postives = 138/158 (87.34%), Query Frame = 3

Query:  102 LNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            ++  +++  R+LT +Q+ EI EAF+LFD+DKD  +S YEFKV+LRALGFE+KK +V K L D+NIK+D+ K++F+DFNEIV++MIL+RDP TEMIRAFKLFD+D+SGKI+YRNLKKV++ELGE L+D E+RAMIEEFD+DGDG++N+EEFMA+M  EI
Sbjct:    6 VDNIRRRKRRELTPEQKQEIVEAFDLFDTDKDQEISYYEFKVALRALGFELKKQEVLKTLEDYNIKEDSGKLRFEDFNEIVTDMILDRDPVTEMIRAFKLFDEDDSGKITYRNLKKVSKELGENLSDQELRAMIEEFDQDGDGALNLEEFMALMTKEI 163

[Close]

BLAST of Centrin-3 vs. TrEMBL
Match: A0A4Z2DG98 (Centrin-3 isoform 5 OS=Schistosoma japonicum OX=6182 GN=EWB00_001301 PE=4 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 1.333e-68
Identity = 103/158 (65.19%), Postives = 138/158 (87.34%), Query Frame = 3

Query:  102 LNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            ++  +++  R+LT +Q+ EI EAF+LFD+DKD  +S YEFKV+LRALGFE+KK +V K L D+NIK+D+ K++F+DFNEIV++MIL+RDP TEMIRAFKLFD+D+SGKI+YRNLKKV++ELGE L+D E+RAMIEEFD+DGDG++N+EEFMA+M  EI
Sbjct:   15 VDNIRRRKRRELTPEQKQEIVEAFDLFDTDKDQEISYYEFKVALRALGFELKKQEVLKTLEDYNIKEDSGKLRFEDFNEIVTDMILDRDPVTEMIRAFKLFDEDDSGKITYRNLKKVSKELGENLSDQELRAMIEEFDQDGDGALNLEEFMALMTKEI 172

[Close]

BLAST of Centrin-3 vs. TrEMBL
Match: A0A095CB30 (Centrin-3 OS=Schistosoma haematobium OX=6185 GN=MS3_08102 PE=4 SV=1)

HSP 1 Score: 218.009 bits (554), Expect = 1.452e-68
Identity = 102/162 (62.96%), Postives = 138/162 (85.19%), Query Frame = 3

Query:   90 MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            M   ++  +++  R+LT  Q+ EI EAF+LFD+DKD  +S YEFKV+LRALGFE+KK +V K L D+NIK+D+ K++F+DFNEIV++MIL+RDP TEM+RAFKLFD+D+SGKI+YRNLKK+++ELGE L+D E+RAMIEEFD+DGDG++N+EEFMA+M  EI
Sbjct:    1 MLGIIDNIRRRKRRELTAGQKQEIVEAFDLFDTDKDQQISYYEFKVALRALGFELKKQEVLKTLEDYNIKEDSGKLRFEDFNEIVTDMILDRDPVTEMVRAFKLFDEDDSGKITYRNLKKISKELGENLSDQELRAMIEEFDQDGDGALNLEEFMALMTKEI 162

[Close]

BLAST of Centrin-3 vs. TrEMBL
Match: A0A183MM25 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS17100 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 1.499e-68
Identity = 101/154 (65.58%), Postives = 135/154 (87.66%), Query Frame = 3

Query:  114 KKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            +++  R+LT  Q+ EI EAF+LFD+DKD  +S YEFKV+LRALGFE+KK +V K L D+NIK+D+ K++F+DFNEIV++MIL+RDP TEM+RAFKLFD+D+SGKI+YRNLKK+++ELGE L+D E+RAMIEEFD+DGDG++N+EEFMA+M  EI
Sbjct:    6 RRRKRRELTAGQKQEIVEAFDLFDTDKDQQISYYEFKVALRALGFELKKQEVLKTLEDYNIKEDSGKLRFEDFNEIVTDMILDRDPVTEMVRAFKLFDEDDSGKITYRNLKKISKELGENLSDQELRAMIEEFDQDGDGALNLEEFMALMTKEI 159

[Close]

BLAST of Centrin-3 vs. Ensembl Cavefish
Match: cetn3 (centrin 3 [Source:NCBI gene;Acc:103024517])

HSP 1 Score: 194.897 bits (494), Expect = 6.020e-63
Identity = 98/164 (59.76%), Postives = 131/164 (79.88%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            ++R E   +K K+K  R+LT +Q++EI EAFELFD+DKD  +  +E KV++RALGFEVKK DV KIL D++ ++   KI F+DF E+V++ ILERDP  E+++AFKLFDDDESGKIS RNL++VARELGE ++D E+RAMI+EFD DGDG IN EEF++IM G+
Sbjct:    4 SIRTELPADKTKRKKRRELTEEQKDEIKEAFELFDTDKDKEIDYHELKVAMRALGFEVKKVDVLKILKDYD-REGTGKITFEDFREVVTDRILERDPKEEILKAFKLFDDDESGKISLRNLRRVARELGEDMSDEELRAMIDEFDTDGDGEINQEEFVSIMTGD 166

[Close]

BLAST of Centrin-3 vs. Ensembl Cavefish
Match: cetn2 (centrin-1 [Source:NCBI gene;Acc:103028142])

HSP 1 Score: 155.221 bits (391), Expect = 2.897e-47
Identity = 80/153 (52.29%), Postives = 114/153 (74.51%), Query Frame = 3

Query:  111 AKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
             +KKT  K  LT + + EI EAFELFD+D  G +   E KV++RALGFE KK ++ K+++D + KD   KI F+DF  I+++ + E+D   E+++AF+LFDDDE+GKIS+RNLK+VA+ELGE LTD E++ MI+E D+DGDG +N +EF+ IM
Sbjct:   15 PRKKTSPKPELTEEMKQEIREAFELFDTDGSGHIEVKELKVAMRALGFEPKKEEIKKMIADVD-KDGTGKISFNDFLTIMTQKMAEKDSKEEILKAFRLFDDDETGKISFRNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNQQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Cavefish
Match: cetn4 (caltractin [Source:NCBI gene;Acc:103037928])

HSP 1 Score: 147.902 bits (372), Expect = 2.143e-44
Identity = 76/167 (45.51%), Postives = 118/167 (70.66%), Query Frame = 3

Query:   69 LHCQTLRMENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +   + R  ++    +KK   K  LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++D + K+ +  I F+DF  ++++ + E+D   E+++AF+LFDDD +GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN +EF+ IM
Sbjct:    1 MQASSFRKPSATANQRKKGGPKVDLTEEQKQEIREAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEIKKMIADID-KEGSGTINFNDFLSMMTQKMSEKDSKEEILKAFRLFDDDGTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Ensembl Cavefish
Match: cetn4 (caltractin [Source:NCBI gene;Acc:103037928])

HSP 1 Score: 146.362 bits (368), Expect = 8.219e-44
Identity = 72/143 (50.35%), Postives = 109/143 (76.22%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++D + K+ +  I F+DF  ++++ + E+D   E+++AF+LFDDD +GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN +EF+ IM
Sbjct:   24 LTEEQKQEIREAFDLFDTDGSGTIDVKELKVAMRALGFEPKKEEIKKMIADID-KEGSGTINFNDFLSMMTQKMSEKDSKEEILKAFRLFDDDGTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEQEFLRIM 165

[Close]

BLAST of Centrin-3 vs. Ensembl Cavefish
Match: calm3a (calmodulin [Source:NCBI gene;Acc:103037741])

HSP 1 Score: 88.5817 bits (218), Expect = 8.656e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Match: cetn3 (centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152])

HSP 1 Score: 186.037 bits (471), Expect = 4.083e-60
Identity = 89/157 (56.69%), Postives = 127/157 (80.89%), Query Frame = 3

Query:  102 LNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            ++K K++  R++T +Q+ EI EAFELFD+DKDG +  +E KV++RALGFEV K DV KI+ D++ ++D  KI +DDF E+++E +LERDP  E+++AF+LFD+ ESG+I  R+L++VARELGET++D E+RAMI+EFD DGDG IN EEF+AIM G+
Sbjct:   12 MDKGKRRRRREMTEEQKQEIQEAFELFDTDKDGAIDYHELKVAIRALGFEVSKADVIKIMKDYD-REDTGKISYDDFCEVMTERVLERDPLDEVLKAFRLFDEGESGRIGVRDLRRVARELGETVSDEELRAMIDEFDTDGDGEINQEEFIAIMTGD 167

[Close]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Match: CETN1 (centrin 1 [Source:HGNC Symbol;Acc:HGNC:1866])

HSP 1 Score: 155.992 bits (393), Expect = 4.620e-48
Identity = 76/143 (53.15%), Postives = 113/143 (79.02%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            L+ +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K+++DF+ KD + KI F+DF  ++++ + E+D   E+++AF+LFDDDE+GKIS++NLK+VA+ELGETLTD E++ MI+E D+DGDG IN EEF+ +M
Sbjct:   36 LSEEQKQEIKEAFDLFDADGSGTIDVKELKVAMRALGFEPKKEEIKKMIADFD-KDGSGKINFNDFLAMMTQKMSEKDSREEILKAFRLFDDDETGKISFKNLKRVAKELGETLTDEELQEMIDEADRDGDGEINEEEFLRVM 177

[Close]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Match: CALML3 (calmodulin like 3 [Source:HGNC Symbol;Acc:HGNC:1452])

HSP 1 Score: 88.5817 bits (218), Expect = 1.683e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Match: CALM3 (calmodulin 3 [Source:HGNC Symbol;Acc:HGNC:1449])

HSP 1 Score: 88.5817 bits (218), Expect = 1.756e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006008.1 (pep scaffold:Pmarinus_7.0:GL476713:142259:146509:-1 gene:ENSPMAG00000005430.1 transcript:ENSPMAT00000006008.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 87.8113 bits (216), Expect = 3.306e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITVKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Yeast
Match: CDC31 (Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation [Source:SGD;Acc:S000005783])

HSP 1 Score: 149.443 bits (376), Expect = 4.669e-46
Identity = 76/144 (52.78%), Postives = 107/144 (74.31%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +L  +Q+ EI EAF LFD + DG L  +E KV+++ALGFE+ K ++  ++ +++  +    +K+DDF  ++ E IL+RDP  E+ RAF+LFDDD +GKIS +NL++VA+ELGETLTD E+RAMIEEFD DGDG IN  EF+AI 
Sbjct:   16 ELLEEQKQEIYEAFSLFDMNNDGFLDYHELKVAMKALGFELPKREILDLIDEYD-SEGRHLMKYDDFYIVMGEKILKRDPLDEIKRAFQLFDDDHTGKISIKNLRRVAKELGETLTDEELRAMIEEFDLDGDGEINENEFIAIC 158

[Close]

BLAST of Centrin-3 vs. Ensembl Yeast
Match: CMD1 (Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability [Source:SGD;Acc:S000000313])

HSP 1 Score: 89.3521 bits (220), Expect = 6.771e-23
Identity = 51/144 (35.42%), Postives = 83/144 (57.64%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMN 566
            LT +Q  E  EAF LFD D +G +S  E    +R+LG    + +V  ++++ ++ D   +I+F +F  ++S  +   D   E++ AFK+FD +  G IS   LK V   +GE LTD E+  M+ E   DG G IN+++F A+++
Sbjct:    5 LTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVNDLMNEIDV-DGNHQIEFSEFLALMSRQLKSNDSEQELLEAFKVFDKNGDGLISAAELKHVLTSIGEKLTDAEVDDMLREV-SDGSGEINIQQFAALLS 146

HSP 2 Score: 49.6766 bits (117), Expect = 3.169e-8
Identity = 26/73 (35.62%), Postives = 40/73 (54.79%), Query Frame = 3

Query:  357 LERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            L  +   E   AF LFD D +G IS   L  V R LG + ++ E+  ++ E D DG+  I   EF+A+M+ ++
Sbjct:    5 LTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVNDLMNEIDVDGNHQIEFSEFLALMSRQL 77

[Close]

BLAST of Centrin-3 vs. Ensembl Yeast
Match: MLC1 (Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition [Source:SGD;Acc:S000003074])

HSP 1 Score: 58.151 bits (139), Expect = 3.205e-11
Identity = 37/133 (27.82%), Postives = 69/133 (51.88%), Query Frame = 3

Query:  171 FELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTT-----EMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFM 554
            F LFD    G +++      LRA+G+      V  I++  +   DA  +  D    ++     E D TT     + ++AF++FD + +GK+S  +L+ +   LGE LTD E+  +++  + D +G I+ ++F+
Sbjct:   11 FTLFDKKGQGAIAKDSLGDYLRAIGYNPTNQLVQDIINADSSLRDASSLTLDQITGLIEVNEKELDATTKAKTEDFVKAFQVFDKESTGKVSVGDLRYMLTGLGEKLTDAEVDELLKGVEVDSNGEIDYKKFI 143

[Close]

BLAST of Centrin-3 vs. Ensembl Nematostella
Match: EDO44944 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU39])

HSP 1 Score: 186.422 bits (472), Expect = 5.021e-60
Identity = 91/156 (58.33%), Postives = 123/156 (78.85%), Query Frame = 3

Query:  105 NKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            N+  K   R+L  +QR EI EAF LFD+DKD  +  +E KV++RALGF+VKK DV KI+ D++ ++   KI FDDFNE++++ +L+RDP  E+ +AF+LFDDD+SGKIS RNL++VARELGE +TD E+RAMI+EFDKDGDG IN +EF+AIM G+
Sbjct:   13 NRGSKPKRRELGEEQRQEIKEAFNLFDTDKDQAIDYHELKVAMRALGFDVKKADVLKIMKDYD-RESTGKISFDDFNEVMTDWMLDRDPQEEVFKAFRLFDDDDSGKISLRNLRRVARELGENMTDEELRAMIDEFDKDGDGEINEDEFLAIMTGD 167

[Close]

BLAST of Centrin-3 vs. Ensembl Nematostella
Match: EDO40775 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S690])

HSP 1 Score: 150.214 bits (378), Expect = 6.212e-46
Identity = 79/152 (51.97%), Postives = 114/152 (75.00%), Query Frame = 3

Query:  114 KKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +KKT  K  LT +Q+ EI EAF+LFD+D  G +   E KV++RALGFE KK ++ K++SD + KD +  I F++F ++++  + E+D   E+++AFKLFDDDE+GKIS++NLK+VA+ELGE LTD E++ MI+E D+DGDG IN  EF+ IM
Sbjct:    6 RKKTGPKPELTEEQKQEIREAFDLFDTDGSGTIDAKELKVAMRALGFEPKKEEIKKMISDID-KDGSGTIDFNEFLQMMTAKMSEKDSKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEINEAEFLRIM 156

HSP 2 Score: 51.2174 bits (121), Expect = 2.655e-8
Identity = 29/73 (39.73%), Postives = 40/73 (54.79%), Query Frame = 3

Query:  357 LERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            L  +   E+  AF LFD D SG I  + LK   R LG      EI+ MI + DKDG G+I+  EF+ +M  ++
Sbjct:   15 LTEEQKQEIREAFDLFDTDGSGTIDAKELKVAMRALGFEPKKEEIKKMISDIDKDGSGTIDFNEFLQMMTAKM 87

[Close]

BLAST of Centrin-3 vs. Ensembl Nematostella
Match: EDO41859 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2Y1])

HSP 1 Score: 101.679 bits (252), Expect = 4.683e-27
Identity = 55/154 (35.71%), Postives = 96/154 (62.34%), Query Frame = 3

Query:  105 NKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNE-IVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
             K   +  + LT  +  ++   F+ FD+DK G +   E + ++R LGF++ K  +  +++D +  D + +I+FD+F + I+S+    RD   E+++ FK+FD D+SG+I+  NLK+V+R  G  L + E++ MI E DKDGD SI+ +EF+ +M
Sbjct:    3 GKVGARAYQHLTPQEIRDLKLVFDTFDTDKSGSIDGRELRKAMRTLGFKISKEGIAGMIADLD-ADQSGRIEFDEFLDFIISKQSDGRDVHDEIVQGFKMFDTDQSGRITLENLKQVSRMCGVKLNETELKEMILEADKDGDSSIDQDEFINMM 155

[Close]

BLAST of Centrin-3 vs. Ensembl Nematostella
Match: EDO30674 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T043])

HSP 1 Score: 98.2117 bits (243), Expect = 1.335e-25
Identity = 53/144 (36.81%), Postives = 87/144 (60.42%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +LT +QRNE+ EAF LFD D  G +S  E +V +++LG      ++ +++ + +  D   ++ F++F  ++ + +  RD   EM  AF++FD +  G IS   L+ V   LGE L+D EI+ M+ E D DGDG IN +EF+ ++
Sbjct:   12 ELTAEQRNELQEAFSLFDKDGSGTISNEELEVVMKSLGQNPSDEELQQMIQEVDA-DGNGEVDFEEFLAMMKKQMQHRDAEAEMREAFRVFDRNGDGSISEWELRSVMASLGEKLSDDEIKEMMREADLDGDGVINFQEFVQMV 154

[Close]

BLAST of Centrin-3 vs. Ensembl Nematostella
Match: EDO33580 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRU7])

HSP 1 Score: 89.7373 bits (221), Expect = 1.218e-22
Identity = 50/143 (34.97%), Postives = 87/143 (60.84%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT ++  E  EAF LFD D DG ++  E    +R LG      ++ +++ + + +D +  I F++F +++S+    +    E++ AF++FD D +G I+   LK+V   LGE L++ E+  MI+E D DGDG++N+EEF+ +M
Sbjct:    5 LTEEEIAEYKEAFSLFDKDGDGTVTTAELGTVMRNLGQNPTDEEIREMIKEVD-EDGSGSIGFEEFLQLMSKKTKGKSYEDELMAAFQIFDKDGNGSITVTELKEVLDSLGEKLSEDEVGEMIKEADSDGDGTVNIEEFIKMM 146

HSP 2 Score: 61.6178 bits (148), Expect = 4.469e-12
Identity = 32/70 (45.71%), Postives = 41/70 (58.57%), Query Frame = 3

Query:  357 LERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMN 566
            L  +   E   AF LFD D  G ++   L  V R LG+  TD EIR MI+E D+DG GSI  EEF+ +M+
Sbjct:    5 LTEEEIAEYKEAFSLFDKDGDGTVTTAELGTVMRNLGQNPTDEEIREMIKEVDEDGSGSIGFEEFLQLMS 74

[Close]

BLAST of Centrin-3 vs. Ensembl Medaka
Match: cetn3 (centrin 3 [Source:NCBI gene;Acc:101165824])

HSP 1 Score: 181.8 bits (460), Expect = 1.100e-57
Identity = 93/164 (56.71%), Postives = 128/164 (78.05%), Query Frame = 3

Query:   81 TLRMENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGE 572
            +LR + + +K K    R+LT +Q++E+ EAF+LFD+DKD  +  +E KV++RALGFEVKK DV KIL D++ +D   KI F+DF+E+V++ ILERDP  E+++AFKLFDDDESG+IS RNL++VARELGE + D E+R+MI+EFD D DG IN EEF+AIM  +
Sbjct:    4 SLRTDQA-DKNKPNKRRELTEEQKHEVKEAFDLFDTDKDRQIDYHELKVAMRALGFEVKKMDVLKILKDYD-RDGNRKITFEDFSEVVTDRILERDPKEEVLKAFKLFDDDESGRISLRNLRRVARELGEDINDEELRSMIDEFDTDRDGEINQEEFLAIMTAD 165

[Close]

BLAST of Centrin-3 vs. Ensembl Medaka
Match: cetn2 (caltractin [Source:NCBI gene;Acc:101170769])

HSP 1 Score: 156.377 bits (394), Expect = 1.044e-47
Identity = 79/160 (49.38%), Postives = 116/160 (72.50%), Query Frame = 3

Query:   90 MENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            ++  +   +KKT  K  LT +Q+ EI EAFELFD+D  G +   + KV++RALGFE KK ++ K++ + + KD   KI F DF  ++++ + E+D   E+++AF+LFDDDE+GKIS+RNLK+VA+ELGE LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:   11 LQGPVPPPRKKTTPKAELTEEQKQEIREAFELFDTDGSGFIDVKDLKVAMRALGFEPKKEEIKKMIGEVD-KDATGKISFADFLTVMTQKMAEKDSKEEILKAFRLFDDDETGKISFRNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNQEEFLRIM 169

[Close]

Query:   90 MENSLNKAKKKTLRK--LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            ++  +   +KKT  K  LT +Q+ EI EAFELFD+D  G +   + KV++RALGFE KK ++ K++ + + KD   KI F DF  ++++ + E+D   E+++AF+LFDDDE+GKIS+RNLK+VA+ELGE LTD E++ MI+E D+DGDG +N EEF+ IM
Sbjct:   11 LQGPVPPPRKKTTPKAELTEEQKQEIREAFELFDTDGSGFIDVKDLKVAMRALGFEPKKEEIKKMIGEVD-KDATGKISFADFLTVMTQKMAEKDSKEEILKAFRLFDDDETGKISFRNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNQEEFLRIM 169

[Close]

BLAST of Centrin-3 vs. Ensembl Medaka
Match: calm2a (calmodulin 2 [Source:NCBI gene;Acc:100049420])

HSP 1 Score: 88.5817 bits (218), Expect = 8.602e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Ensembl Medaka
Match: ENSORLT00000008599.2 (calmodulin 3 [Source:NCBI gene;Acc:100049421])

HSP 1 Score: 88.5817 bits (218), Expect = 8.602e-22
Identity = 53/146 (36.30%), Postives = 82/146 (56.16%), Query Frame = 3

Query:  132 KLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNG 569
            +LT +Q  E  EAF LFD D DG ++  E    +R+LG    + ++  ++++ +  D    I F +F  +++  + + D   E+  AF++FD D +G IS   L+ V   LGE LTD E+  MI E D DGDG +N EEF+ +M  
Sbjct:    4 QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD-ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA 148

[Close]

BLAST of Centrin-3 vs. Planmine SMEST
Match: SMESG000016538.1 (SMESG000016538.1)

HSP 1 Score: 322.398 bits (825), Expect = 2.419e-113
Identity = 162/162 (100.00%), Postives = 162/162 (100.00%), Query Frame = 3

Query:   90 MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 575
            MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI
Sbjct:    1 MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIMNGEI 162

[Close]

BLAST of Centrin-3 vs. Planmine SMEST
Match: SMESG000052182.1 (SMESG000052182.1)

HSP 1 Score: 118.242 bits (295), Expect = 1.205e-33
Identity = 58/111 (52.25%), Postives = 87/111 (78.38%), Query Frame = 3

Query:  231 LRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +RALGFE KK +V K+++D++I+     I+F DF  ++++ + E+D   E+++AFKLFDDDE+GKIS++NLK+VA+ELGE LTD E++ MI+E D+D DG IN +EF+ IM
Sbjct:    1 MRALGFEPKKEEVRKLIADYDIEGKGI-IEFSDFLSMMTQKMAEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDNDGEINEQEFLRIM 110

[Close]

BLAST of Centrin-3 vs. Planmine SMEST
Match: SMESG000015458.1 (SMESG000015458.1)

HSP 1 Score: 117.472 bits (293), Expect = 1.022e-32
Identity = 63/143 (44.06%), Postives = 98/143 (68.53%), Query Frame = 3

Query:  135 LTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            LT +Q+ E+ EAF+LFD+D  G +   E KV++RALGFE KK +V K+++D++I+     I+F DF  ++++ + E+D   E+++AFKLFDDDE+ K   +  KK  + +   LTD E++ MI+E D+D DG IN +EF+ IM
Sbjct:   26 LTEEQKQEVREAFDLFDADGSGTIDIKELKVAMRALGFEPKKEEVRKLIADYDIEGKGI-IEFSDFLSMMTQKMAEKDTKEEILKAFKLFDDDETEKFLLK-FKKSCKRIRRNLTDEELQEMIDEADRDNDGEINEQEFLRIM 166

[Close]

BLAST of Centrin-3 vs. Planmine SMEST
Match: SMESG000015458.1 (SMESG000015458.1)

HSP 1 Score: 88.9669 bits (219), Expect = 2.091e-22
Identity = 48/111 (43.24%), Postives = 76/111 (68.47%), Query Frame = 3

Query:  231 LRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSINMEEFMAIM 563
            +RALGFE KK +V K+++D++I+     I+F DF  ++++ + E+D   E+++AFKLFDDDE+ K   +  KK  + +   LTD E++ MI+E D+D DG IN +EF+ IM
Sbjct:    1 MRALGFEPKKEEVRKLIADYDIEGKGI-IEFSDFLSMMTQKMAEKDTKEEILKAFKLFDDDETEKFLLK-FKKSCKRIRRNLTDEELQEMIDEADRDNDGEINEQEFLRIM 109

[Close]

BLAST of Centrin-3 vs. Planmine SMEST
Match: SMESG000040368.1 (SMESG000040368.1)

HSP 1 Score: 89.3521 bits (220), Expect = 2.469e-22
Identity = 53/133 (39.85%), Postives = 83/133 (62.41%), Query Frame = 3

Query:  117 KKTLRKLTVD----QRNEINEAFELFDSDKDGLLSQYEFKVSLRALGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIRAFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMI 503
            KK + K+T++    Q+ +I +AF LFD D  G +   E KV+LRAL FE  K D+ K++S+++ KD+   I F++F  ++S  + E D   ++ +AF LFD D   KIS  NLK ++  LGE LTD E++ ++
Sbjct:    4 KKKVDKMTIELSEKQKEDIQKAFNLFDKDGSGTIDIQEVKVALRALDFEPLKDDIRKLISEYD-KDNKGTIDFNNFLILISSKMTEPDSKEDITKAFNLFDKDGKEKISIHNLKSISEILGENLTDEELQVVL 135

The following BLAST results are available for this feature:

BLAST of Centrin-3 vs. Ensembl Human
BLAST of Centrin-3 vs. Ensembl Celegans
BLAST of Centrin-3 vs. Ensembl Fly
BLAST of Centrin-3 vs. Ensembl Zebrafish
BLAST of Centrin-3 vs. Ensembl Xenopus
BLAST of Centrin-3 vs. Ensembl Mouse
BLAST of Centrin-3 vs. UniProt/SwissProt
BLAST of Centrin-3 vs. TrEMBL
BLAST of Centrin-3 vs. Ensembl Cavefish
BLAST of Centrin-3 vs. Ensembl Sea Lamprey
BLAST of Centrin-3 vs. Ensembl Yeast
BLAST of Centrin-3 vs. Ensembl Nematostella
BLAST of Centrin-3 vs. Ensembl Medaka
BLAST of Centrin-3 vs. Planmine SMEST

BLAST of Centrin-3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CETN3	6.873e-65	60.61	centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868]	[more]
CETN3	4.452e-59	52.91	centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868]	[more]
CETN3	1.207e-56	60.00	centrin 3 [Source:HGNC Symbol;Acc:HGNC:1868]	[more]
CETN1	3.271e-44	50.35	centrin 1 [Source:HGNC Symbol;Acc:HGNC:1866]	[more]
CETN2	5.681e-44	46.84	centrin 2 [Source:HGNC Symbol;Acc:HGNC:1867]	[more]

BLAST of Centrin-3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cmd-1	9.147e-22	36.55	Calmodulin [Source:UniProtKB/Swiss-Prot;Acc:O1630...	[more]
cal-1	3.735e-21	29.59	Calmodulin-like protein [Source:UniProtKB/Swiss-P...	[more]
cal-1	6.241e-21	30.49	Calmodulin-like protein [Source:UniProtKB/Swiss-P...	[more]
tnc-2	1.180e-17	27.92	Troponin C, isoform 2 [Source:UniProtKB/Swiss-Pro...	[more]
cal-2	1.287e-16	34.81	CALmodulin related genes; Calmodulin-like protein ...	[more]

BLAST of Centrin-3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG17493	8.710e-43	46.63	gene:FBgn0040010 transcript:FBtr0332630	[more]
CG17493	8.710e-43	46.63	gene:FBgn0040010 transcript:FBtr0332632	[more]
CG17493	8.710e-43	46.63	gene:FBgn0040010 transcript:FBtr0332631	[more]
CG31802	3.920e-34	41.96	gene:FBgn0051802 transcript:FBtr0081058	[more]
Cam	1.276e-21	36.55	gene:FBgn0000253 transcript:FBtr0304964	[more]

BLAST of Centrin-3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cetn3	3.460e-63	59.15	centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152]	[more]
cetn3	4.025e-62	58.90	centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152]	[more]
cetn2	1.324e-46	51.75	centrin, EF-hand protein, 2 [Source:ZFIN;Acc:ZDB-G...	[more]
cetn4	9.593e-44	48.72	centrin 4 [Source:ZFIN;Acc:ZDB-GENE-030826-21]	[more]
calm2a	9.791e-22	36.30	calmodulin 2a (phosphorylase kinase, delta) [Sourc...	[more]

BLAST of Centrin-3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rab38	3.067e-65	60.00	RAB38, member RAS oncogene family [Source:Xenbase;...	[more]
cetn1	1.132e-44	48.41	centrin 1 [Source:NCBI gene;Acc:549903]	[more]
cetn1	1.156e-44	51.05	centrin 1 [Source:NCBI gene;Acc:549903]	[more]
dtl	3.772e-44	52.45	denticleless E3 ubiquitin protein ligase homolog [...	[more]
dtl	5.150e-44	52.45	denticleless E3 ubiquitin protein ligase homolog [...	[more]

BLAST of Centrin-3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cetn3	6.403e-65	60.61	centrin 3 [Source:MGI Symbol;Acc:MGI:1097706]	[more]
Cetn3	1.005e-50	64.80	centrin 3 [Source:MGI Symbol;Acc:MGI:1097706]	[more]
Cetn1	3.873e-46	46.99	centrin 1 [Source:MGI Symbol;Acc:MGI:1347086]	[more]
Cetn1	3.873e-46	46.99	centrin 1 [Source:MGI Symbol;Acc:MGI:1347086]	[more]
Cetn1	3.873e-46	46.99	centrin 1 [Source:MGI Symbol;Acc:MGI:1347086]	[more]

BLAST of Centrin-3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O15182\|CETN3_HUMAN	3.300e-64	60.61	Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV...	[more]
sp\|O35648\|CETN3_MOUSE	4.479e-64	60.61	Centrin-3 OS=Mus musculus OX=10090 GN=Cetn3 PE=1 S...	[more]
sp\|Q24956\|CATR_GIAIN	2.672e-46	47.10	Caltractin OS=Giardia intestinalis OX=5741 GN=CAL ...	[more]
sp\|P41209\|CETN1_MOUSE	2.709e-45	46.99	Centrin-1 OS=Mus musculus OX=10090 GN=Cetn1 PE=1 S...	[more]
sp\|O74435\|CDC31_SCHPO	2.834e-45	54.17	Cell division control protein 31 OS=Schizosaccharo...	[more]

BLAST of Centrin-3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4E0RN29	2.804e-72	68.13	Centrin EF-hand protein 3 OS=Fasciola hepatica OX=...	[more]
Q5DG25	1.331e-68	65.19	Centrin-3 OS=Schistosoma japonicum OX=6182 GN=EWB0...	[more]
A0A4Z2DG98	1.333e-68	65.19	Centrin-3 isoform 5 OS=Schistosoma japonicum OX=61...	[more]
A0A095CB30	1.452e-68	62.96	Centrin-3 OS=Schistosoma haematobium OX=6185 GN=MS...	[more]
A0A183MM25	1.499e-68	65.58	Uncharacterized protein OS=Schistosoma margrebowie...	[more]

BLAST of Centrin-3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cetn3	6.020e-63	59.76	centrin 3 [Source:NCBI gene;Acc:103024517]	[more]
cetn2	2.897e-47	52.29	centrin-1 [Source:NCBI gene;Acc:103028142]	[more]
cetn4	2.143e-44	45.51	caltractin [Source:NCBI gene;Acc:103037928]	[more]
cetn4	8.219e-44	50.35	caltractin [Source:NCBI gene;Acc:103037928]	[more]
calm3a	8.656e-22	36.30	calmodulin [Source:NCBI gene;Acc:103037741]	[more]

BLAST of Centrin-3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cetn3	4.083e-60	56.69	centrin 3 [Source:ZFIN;Acc:ZDB-GENE-050522-152]	[more]
CETN1	4.620e-48	53.15	centrin 1 [Source:HGNC Symbol;Acc:HGNC:1866]	[more]
CALML3	1.683e-22	36.30	calmodulin like 3 [Source:HGNC Symbol;Acc:HGNC:145...	[more]
CALM3	1.756e-22	36.30	calmodulin 3 [Source:HGNC Symbol;Acc:HGNC:1449]	[more]
ENSPMAT00000006008.1	3.306e-22	36.30	pep scaffold:Pmarinus_7.0:GL476713:142259:146509:-...	[more]

BLAST of Centrin-3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
CDC31	4.669e-46	52.78	Calcium-binding component of the spindle pole body...	[more]
CMD1	6.771e-23	35.42	Calmodulin; Ca2+ binding protein that regulates Ca...	[more]
MLC1	3.205e-11	27.82	Essential light chain for Myo1p; light chain for M...	[more]

BLAST of Centrin-3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO44944	5.021e-60	58.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40775	6.212e-46	51.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41859	4.683e-27	35.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30674	1.335e-25	36.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33580	1.218e-22	34.97	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Centrin-3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cetn3	1.100e-57	56.71	centrin 3 [Source:NCBI gene;Acc:101165824]	[more]
cetn2	1.044e-47	49.38	caltractin [Source:NCBI gene;Acc:101170769]	[more]
cetn2	1.044e-47	49.38	caltractin [Source:NCBI gene;Acc:101170769]	[more]
calm2a	8.602e-22	36.30	calmodulin 2 [Source:NCBI gene;Acc:100049420]	[more]
ENSORLT00000008599.2	8.602e-22	36.30	calmodulin 3 [Source:NCBI gene;Acc:100049421]	[more]

BLAST of Centrin-3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000016538.1	2.419e-113	100.00	SMESG000016538.1	[more]
SMESG000052182.1	1.205e-33	52.25	SMESG000052182.1	[more]
SMESG000015458.1	1.022e-32	44.06	SMESG000015458.1	[more]
SMESG000015458.1	2.091e-22	43.24	SMESG000015458.1	[more]
SMESG000040368.1	2.469e-22	39.85	SMESG000040368.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022522 ID=SMED30022522|Name=Centrin-3|organism=Schmidtea mediterranea sexual|type=transcript|length=739bp
TTTGATGCTAGTTACTACTAGCGTATATTTAAATTTAAATTTGCTATTTG
CATTACTAATAATCTTAACTACATTGTCAGACTTTAAGAATGGAAAATTC
TTTAAATAAAGCAAAGAAAAAAACTTTACGCAAACTTACTGTCGATCAGA
GGAATGAAATAAATGAAGCTTTTGAGCTTTTTGATTCAGATAAAGATGGA
CTTTTAAGTCAGTACGAGTTTAAAGTCTCATTGCGAGCACTTGGATTCGA
AGTCAAAAAGCACGATGTTACTAAAATATTGAGTGATTTTAATATTAAAG
ATGATGCCCCTAAAATTAAATTTGATGATTTTAATGAAATTGTTTCTGAA
ATGATTCTCGAACGAGATCCGACAACCGAAATGATTCGTGCTTTCAAATT
ATTTGATGATGACGAATCTGGAAAAATTAGCTATCGTAATTTGAAAAAAG
TTGCAAGAGAGTTGGGTGAAACCTTAACTGATCACGAAATACGAGCGATG
ATCGAAGAATTTGATAAAGATGGAGATGGATCTATTAACATGGAGGAATT
CATGGCTATCATGAATGGAGAAATATAATTATTTTATTAATATATTTAAA
TGCAGTTTAACCCATTTGTCCTGTGATTTTATTTTGTTCTCATCGTTTCA
TAATCTTGTACATCTATTTCAGCCTGACAAATGAATGATGTTTCTACTAG
TATAAGTGTTATATTAGACTTCATTTTTATTTTATAAAT

protein sequence of SMED30022522-orf-1

>SMED30022522-orf-1 ID=SMED30022522-orf-1|Name=SMED30022522-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=163bp
MENSLNKAKKKTLRKLTVDQRNEINEAFELFDSDKDGLLSQYEFKVSLRA
LGFEVKKHDVTKILSDFNIKDDAPKIKFDDFNEIVSEMILERDPTTEMIR
AFKLFDDDESGKISYRNLKKVARELGETLTDHEIRAMIEEFDKDGDGSIN
MEEFMAIMNGEI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0002075	pigment cell

Vocabulary: **INTERPRO**
Term	Definition
IPR002048	EF_hand_dom
IPR011992	EF-hand-dom_pair
IPR018247	EF_Hand_1_Ca_BS

Vocabulary: **molecular function**
Term	Definition
GO:0005509	calcium ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002048	EF-hand domain	SMART	SM00054	efh_1	coord: 133..161 e-value: 3.9E-6 score: 36.4 coord: 23..51 e-value: 2.8E-4 score: 30.2 coord: 97..125 e-value: 0.091 score: 21.9
IPR002048	EF-hand domain	PFAM	PF13499	EF-hand_7	coord: 97..158 e-value: 1.3E-15 score: 57.6 coord: 22..85 e-value: 9.0E-8 score: 32.5
IPR002048	EF-hand domain	PROSITE	PS50222	EF_HAND_2	coord: 129..162 score: 14.151
IPR002048	EF-hand domain	PROSITE	PS50222	EF_HAND_2	coord: 19..54 score: 13.76
IPR002048	EF-hand domain	PROSITE	PS50222	EF_HAND_2	coord: 93..128 score: 11.166
IPR002048	EF-hand domain	CDD	cd00051	EFh	coord: 97..158 e-value: 1.09888E-14 score: 62.9505
None	No IPR available	GENE3D	G3DSA:1.10.238.10		coord: 9..88 e-value: 5.3E-16 score: 60.3
None	No IPR available	GENE3D	G3DSA:1.10.238.10		coord: 89..161 e-value: 3.7E-23 score: 83.5
None	No IPR available	PANTHER	PTHR23050:SF325	CENTRIN-3	coord: 13..160
None	No IPR available	PANTHER	PTHR23050	CALCIUM BINDING PROTEIN	coord: 13..160
IPR018247	EF-Hand 1, calcium-binding site	PROSITE	PS00018	EF_HAND_1	coord: 32..44
IPR018247	EF-Hand 1, calcium-binding site	PROSITE	PS00018	EF_HAND_1	coord: 142..154
IPR011992	EF-hand domain pair	SUPERFAMILY	SSF47473	EF-hand	coord: 16..158