Disintegrin and metalloproteinase domain-containing protein 15

Query:  748 MPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIK--LTDENHILMELQLYKRRFI--NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW    +   +     +L     ++ +F+   +RHD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +   +CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     GT+CR    E CD+PEYCNG S++C  DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  E  +      +      G  C  V F L   + D GMV  G  CG+G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ PNC T
Sbjct:  208 LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGNCLLN------------------IPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDP--CCEGSTCKLKSFAECAYGDCC--KDCRFLPGGTLCRGKTSE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN----KAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGF------------SGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCET 675          

Query:  748 MPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIK--LTDENHILMELQLYKRRFI--NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW    +   +     +L     ++ +F+   +RHD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +   +CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     GT+CR    E CD+PEYCNG S++C  DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  E  +      +      G  C  V F L   + D GMV  G  CG+G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ PNC T
Sbjct:  208 LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGNCLLN------------------IPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDP--CCEGSTCKLKSFAECAYGDCC--KDCRFLPGGTLCRGKTSE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN----KAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGF------------SGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCET 675          

Query:  220 WLRLNSINNPKYSLWLHLELKKQNQFPILVR---KNENKV----DWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-----GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV-NG--YHCSAVRF----DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            W R +   +PK    L +   K ++ P+  +   K E +V      +  D + ++ L++ +     Y++  +  TTT ++E    +   + + +    +  ++S C GI G+  + ++  Y+     +    +  Q L        PP              DW     Q++K+    M  +++     VELY++ D  +       + +    ++  I N ++  +   NI   ++ LE+W    +    EN    L     ++R+ +  K HD    I G +      G + + +MC   +  G   D+ S+N I ++  + HE+GHNFG+ HD+  C        GCIMA       F   ++ C++ E+   L+SG   CL + P + M                       +CGNG ++ GE+CD     + E  +N CCN   C    GA CA GSCC   +C L   GT+CR  +   CDLPE+C G+S  CP++ Y+ DG  C     G  ++CY G C + + +CQ+LWG  A  + D+C++ +N  GD   NCG ++           N   + C+   + CG++ C+    R L  +   ++  I+ NG    C         + +  + D G+V  G  CG   IC++ +C   +  E   C   C+ HG CNN  NCHC PG++ P C T
Sbjct:   30 WTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETE---LSSVTLSTCRGIRGLITVSSNLSYVI----EPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVAD-YLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDH-SENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGH-PFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGG------------------RRCGNGYLEDGEECD---CGEEEECNNPCCNASNCTLRPGAECAHGSCC--HQCKLLAPGTLCRE-QARQCDLPEFCTGKSPHCPTNFYQMDGTPCE----GGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDM-----------NGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683          

Query:  220 WLRLNSINNPKYSLWLHLELKKQNQFPILVR---KNENKV----DWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-----GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV-NG--YHCSAVRF----DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            W R +   +PK    L +   K ++ P+  +   K E +V      +  D + ++ L++ +     Y++  +  TTT ++E    +   + + +    +  ++S C GI G+  + ++  Y+     +    +  Q L        PP              DW     Q++K+    M  +++     VELY++ D  +       + +    ++  I N ++  +   NI   ++ LE+W    +    EN    L     ++R+ +  K HD    I G +      G + + +MC   +  G   D+ S+N I ++  + HE+GHNFG+ HD+  C        GCIMA       F   ++ C++ E+   L+SG   CL + P + M                       +CGNG ++ GE+CD     + E  +N CCN   C    GA CA GSCC   +C L   GT+CR  +   CDLPE+C G+S  CP++ Y+ DG  C     G  ++CY G C + + +CQ+LWG  A  + D+C++ +N  GD   NCG ++           N   + C+   + CG++ C+    R L  +   ++  I+ NG    C         + +  + D G+V  G  CG   IC++ +C   +  E   C   C+ HG CNN  NCHC PG++ P C T
Sbjct:   30 WTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETE---LSSVTLSTCRGIRGLITVSSNLSYVI----EPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADY-LEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDH-SENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAAT-GHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGG------------------RRCGNGYLEDGEECD---CGEEEECNNPCCNASNCTLRPGAECAHGSCC--HQCKLLAPGTLCRE-QARQCDLPEFCTGKSPHCPTNFYQMDGTPCE----GGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDM-----------NGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRRFINKR-HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDM-NKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEI-VNGYH--CSAVRFDLDWYLD--DFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +ELYI+ D  +  +    N N+   R+  + N ++      +I   +  LE+W ERD+ ++T D N  L     ++R    +R HD    + G     A  G + +  MC      G + D+ S+  I  +  + HEIGH+ GL HD + C      +  GC+MA       F   +S CS+ ++++  + G   CL + P   +                   + P+ CGNG V+ GE+CDCG  ++C    + CC    C    GA CA G CC   RC LK +G +CR   +  CDLPE+C G S  CP DVY  DG  C+        +C+ G C +   +CQ+LWG  +  + + C+ + N  GD   NCG           Q    +  PC+   ++CG+L C+     +L      ++  + ++G    C          LD    G+V  G  CG   +C    C      E  RC   CH HG CN+  NCHC PG++ P C
Sbjct:  212 LELYIVADHTLF-LTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDH-SELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGH-PFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGL------------------PVPPALCGNGFVEAGEECDCGPGQECR---DLCCFAHNCSLRPGAQCAHGDCC--VRCLLKPAGALCRQA-MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARG----SGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCG-----------QDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFC 680          

Query:  763 LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWER-DQIK-LTDENHILMELQLYKRRFINKRH-DCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQ-----CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVL---RLSEQFLNDEIVNGYHCSAVRFDLDWY-------LDDFGMVPNGVSCGSGRICWKSECVLVNSIEQ--NRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
             VEL ++ D  +   +  D    +   +   MN +N  +   NI  T++  EIW++ DQI  + D    L     YK+  +     D  + +          G++   +MC Y+   G   D+ + + ++      HE+GH FG+ HD        C    CIM    +SG     WS CS   + S    G+  CL +EP            +P+ A          KCGNG+V+ GE+CDCG  K C+   N CCN  TC     A CA G CCDL+ C  K   T+CR   +  CDL EYCNGE+  CP+D + Q+   C  K   E   CY G C SR  +C KLWG T +  ++ CY  N  G    NCG                  K C  E + CG L C  + ER +     S  F +  + +       +F   +          D G+VP+G  CG  ++C   +C     I +   +C  NC+  G CNN GNCHC  GF    C
Sbjct:  178 FVELALVADYSVYTKYDSDE-KKVNDYMQQTMNILNSLYFPLNIRITLVHSEIWKKGDQISVIPDSKETLNNFMEYKKIMLKDHFFDTGYLMTTLKFDEGVVGKAYKGTMCSYDYSGGIYVDH-NNDTVETVATFAHELGHTFGMDHDPNDKDVCYCPMPRCIMNP--QSGHMEV-WSECSVKNLASGFNRGIDLCLFNEP----------GKKPSDA----------KCGNGIVEPGEECDCGPLK-CD---NHCCNGSTCKLIGEAECASGDCCDLKTCKPKPRATVCR-AAIGICDLDEYCNGETNDCPADFFVQNAALCPGK---ENEFCYEGGCGSRNDQCAKLWGPTGKNGDENCYRKNTEGTFHGNCGTNA----------HTKEIKKCETENAKCGLLQCETQAERPVFGDPGSVTFSHSTVYSSLKRDDKKFCYVFKSAYGGLNAPDPGLVPDGAICGEEQMCIGQKCHKKEKISKVTAQCLDNCNFRGVCNNVGNCHCERGFGGIAC 651          

Query:  763 LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWER-DQIK-LTDENHILMELQLYKRRFINKRH-DCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQ-----CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVL---RLSEQFLNDEIVNGYHCSAVRFDLDWY-------LDDFGMVPNGVSCGSGRICWKSECVLVNSIEQ--NRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
             VEL ++ D  +   +  D    +   +   MN +N  +   NI  T++  EIW++ DQI  + D    L     YK+  +     D  + +          G++   +MC Y+   G   D+ + + ++      HE+GH FG+ HD        C    CIM    +SG     WS CS   + S    G+  CL +EP            +P+ A          KCGNG+V+ GE+CDCG  K C+   N CCN  TC     A CA G CCDL+ C  K   T+CR   +  CDL EYCNGE+  CP+D + Q+   C  K   E   CY G C SR  +C KLWG T +  ++ CY  N  G    NCG                  K C  E + CG L C  + ER +     S  F +  + +       +F   +          D G+VP+G  CG  ++C   +C     I +   +C  NC+  G CNN GNCHC  GF    C
Sbjct:  178 FVELALVADYSVYTKYDSDE-KKVNDYMQQTMNILNSLYFPLNIRITLVHSEIWKKGDQISVIPDSKETLNNFMEYKKIMLKDHFFDTGYLMTTLKFDEGVVGKAYKGTMCSYDYSGGIYVDH-NNDTVETVATFAHELGHTFGMDHDPNDKDVCYCPMPRCIMNP--QSGHMEV-WSECSVKNLASGFNRGIDLCLFNEP----------GKKPSDA----------KCGNGIVEPGEECDCGPLK-CD---NHCCNGSTCKLIGEAECASGDCCDLKTCKPKPRATVCR-AAIGICDLDEYCNGETNDCPADFFVQNAALCPGK---ENEFCYEGGCGSRNDQCAKLWGPTGKNGDENCYRKNTEGTFHGNCGTNA----------HTKEIKKCETENAKCGLLQCETQAERPVFGDPGSVTFSHSTVYSSLKRDDKKFCYVFKSAYGGLNAPDPGLVPDGAICGEEQMCIGQKCHKKEKISKVTAQCLDNCNFRGVCNNVGNCHCERGFGGIAC 651          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQF----NIYFTVIQLEIWERDQ-IKL-TDENHILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCV---GYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYG---CIM------ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGG-SCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYH---CSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--------NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            VE+ +I D +     G  + +     IS+++  +N+A S      NI  + + +E+W   Q I L  D    L  +  Y    I + + D        +        + + S+C     V   G  +     N       +   IGH  GL HDT  C C     C+M        G     FS+ +S CS   +  + + G   CLL++P                     +     +CGNGVVD  E+CDCG R+ C+   + CC+P TC     A CA    CC   RC L+K+G  CR+ +   CD+ E C+G+S  CP D +  DG  C     G    C+RG C+    +CQKLWG  A V+  VC++ N +G   ANCG    R+AD           PC  E + CG L C   +   +  S +          H   C ++           G+  +G +C SGR+C    CV ++S+              C  HG C     C C  G+S   C
Sbjct:  229 VEVALIADYEFMKARGLHDLDA----ISYMLESLNIADSMLSRDLNIRLSAVYVELWTDVQRIDLWEDIERTLSGVVDYASGHIYHIQKDASILFTAGSFANQEVSNAAIRSICTARSAVIVKGVEQFATHWN----GELLAQSIGHLLGLEHDTTACSCEPSPECVMRQQPGRVGGGGGSPFSWQFSKCSVARMHGIWQDGNIQCLLNKP--------------------FQVSELRECGNGVVDGSEECDCGSRENCQ---DPCCDPLTCTLRPHAQCAAHHKCC--HRCELRKAGDTCRSSK-SPCDVAEQCDGKSGDCPPDGHLIDGTVC-----GTDGQCWRGNCSDSHQQCQKLWGREARVAEPVCFEQNTKGAEYANCG---QRQAD-------GTYHPCQIEDTRCGTLHCHSGSITPIDSSLKAFTFHFTENSHQIQCKSIASAA------VGLTSDGTNCASGRVCVAGSCVEMSSVSSATACPTNNLALLCSGHGHCTTTARCVCFNGWSGVAC 698          

Query: 1153 AVLHEIGHNFGLHHD-TEQCKCY----GCIMATGIESGSFSFN--WSNCSKHEIKSLL----KSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCG-GRKQCEAESNKCC---------NPETCLFTVGASCAG--GSCCDLQRCSL--KKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKC 1755
             + HEIGHNFG  HD   +C+        IM     SG    N  +S CS   I ++L    KS   D   +  P  +GK N             +    + CGN + + GE+CDCG  +  C+   +KCC          P  C    GA C+   G CC+   CSL  K    ICR  E E  +L + C+G +  CP    K DGI C +        C  G+C
Sbjct:  423 TLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNC-----------FQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQ-ESECSNL-QTCDGRNAQCPVSPPKHDGIPCQDST----KVCSSGQC 631          

Query:  721 SAFHMPVKEMPGPYLVELYIIVDSKMAAMFG----GDNYNNLFSRISFIMNQINLAFSQ----FNIYFTVIQLEIWERDQIKLTDENHI-----------------------LMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKC-YGCIMATGIESGSFSFNWSNCSKHEIKSLL----KSGMADCLLDEPP 1344
            S+F  P  +   P  +E+ + +DSK+   F      D   +L      ++N +++ + Q     N+   +++ E+W      L+   H                        L ++  Y    +   +D  H        T+  G + +A MC         +  +    +  S  + HE+GHN G+ HD  Q +C  GC + + + +G+    WS+CS  E  + L    +SG  +CL D  P
Sbjct:  223 SSFIFPNMD---PITLEIGLFLDSKLFEHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGVHKNGQAQSLLDAFCRYQAHMNPGTDLTDMNHYDHGVLLTGYDIYHTT------TSVAGVAPVARMCDPLFACSLVEGLH----LGRSFVLAHEMGHNMGMVHDGVQNQCNKGCCLMSAV-NGAGKTTWSDCSVREFNAFLLQLDESGRGNCLRDASP 452          

Query:  691 KFSRHQRSKRSAFHMPVKEMPGPY-------LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILMELQLYKRRFINKR---------HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYG--CIMATGIESGSF-SFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLF-TVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERV-------LRLSEQFLNDE--IVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC------NCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            +FSR    KR       + + GPY        VEL I+VD+K+   F  +N   +      I N IN  +   NI+  ++ + IW E ++I+ + +  + +      R F+N R         +D    +  EN      G++    +C Y    G +  + S N   ++  + HE+GHNFG+ HDT  C C    C+MA    S SF   NWS+CS  ++      GM  CL ++P                  R  ES     CGNG V+ GEQCDCG  + CE   N CCN +TC+  +  A+CA G CCDL  C  K +G+ CR  E E CDLPEYC GESE+CP+DV+++D   C     G  ++C+ G C S  ++C+ LWG T + S + CY+ N  G  + NCG         +R  K +    C ++   CG L C H NER+         LS  +++ +  IV    C     DL     D G+ PNG  CG  ++C    C+ V+++ Q         +C+ +G CN+RG+CHC  GF   +C+
Sbjct:  238 EFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQ-ENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTL------RNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQH-SPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAA--SSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE-----------------RLFES---PTCGNGFVEPGEQCDCGLPEHCE---NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENE-CDLPEYCTGESEYCPADVFRRDTEPCD----GGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EHCYNKNTEGTRLGNCGY--------NRLNKTF--LRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVA---CRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCS 741          

Query:  691 KFSRHQRSKRSAFHMPVKEMPGPY-------LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILMELQLYKRRFINKR---------HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYG--CIMATGIESGSF-SFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLF-TVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERV-------LRLSEQFLNDE--IVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC------NCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            +FSR    KR       + + GPY        VEL I+VD+K+   F  +N   +      I N IN  +   NI+  ++ + IW E ++I+ + +  + +      R F+N R         +D    +  EN      G++    +C Y    G +  + S N   ++  + HE+GHNFG+ HDT  C C    C+MA    S SF   NWS+CS  ++      GM  CL ++P                  R  ES     CGNG V+ GEQCDCG  + CE   N CCN +TC+  +  A+CA G CCDL  C  K +G+ CR  E E CDLPEYC GESE+CP+DV+++D   C     G  ++C+ G C S  ++C+ LWG T + S + CY+ N  G  + NCG         +R  K +    C ++   CG L C H NER+         LS  +++ +  IV    C     DL     D G+ PNG  CG  ++C    C+ V+++ Q         +C+ +G CN+RG+CHC  GF   +C+
Sbjct:  238 EFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQ-ENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTL------RNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQH-SPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAA--SSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE-----------------RLFES---PTCGNGFVEPGEQCDCGLPEHCE---NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENE-CDLPEYCTGESEYCPADVFRRDTEPCD----GGQAYCFHGTCRSHSNQCRTLWGPTGDNS-EHCYNKNTEGTRLGNCGY--------NRLNKTFLR--CEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIV---ACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCS 741          

Query:  676 NAADWKFSRHQRSKRSAFHMPVKEM-------------PGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLY----KRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKC---YGCIMATGI--ESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRH-ENERVLRLSEQFLNDEIVN----GYHCSAVRFDLDW-YLDDFGMVPNGVSCGSGRICWKSECV-LVNSIEQNRC-------NCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            N   W+ SR  +   +     V+E+                  +E  IIVD  M     G     +      + N  +L F   N   +V+ +E W ++Q  +     I   +  +     R       D    + GE       G +   ++C   R VG + D        ++  + H IGHN G+ HD   E+C C   +GCIMA  I  +     + +S CSK +    L++G   CLL++P       N + +  N             CGN VV++ E+CDCG  ++C  +  +CC+  TC     A CA G+CCD  +C L+    ICR+   E CDLPEYC+GE   CPSDV+K++G  C    TG   +C++G C +   +C+ +WG     ++  CY+  N +G +  +CG    R+A       N +   C  E   CG L C+  E + V    +Q  +  I++     + C A    +      + G+V +G  CG   IC    CV L   ++Q +C        C EHG C N   C C  G+   +C++
Sbjct:  229 NLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP-------NEIELRRN-------------CGNKVVEEDEECDCGTFEECALD--QCCDGITCKLKSEAQCASGACCD--QCRLRPKDYICRDSNNE-CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCG----RDA-------NEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSS 756          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLY----KRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKC---YGCIMATGI--ESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRH-ENERVLRLSEQFLNDEIVN----GYHCSAVRFDLDW-YLDDFGMVPNGVSCGSGRICWKSECV-LVNSIEQNRC-------NCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            +E  IIVD  M     G     +      + N  +L F   N   +V+ +E W ++Q  +     I   +  +     R       D    + GE       G +   ++C   R VG + D        ++  + H IGHN G+ HD   E+C C   +GCIMA  I  +     + +S CSK +    L++G   CLL++P       N + +  N             CGN VV++ E+CDCG  ++C  +  +CC+  TC     A CA G+CCD  +C L+    ICR+   E CDLPEYC+GE   CPSDV+K++G  C    TG   +C++G C +   +C+ +WG     ++  CY+  N +G +  +CG    R+A       N +   C  E   CG L C+  E + V    +Q  +  I++     + C A    +      + G+V +G  CG   IC    CV L   ++Q +C        C EHG C N   C C  G+   +C++
Sbjct:  272 IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP-------NEIELRRN-------------CGNKVVEEDEECDCGTFEECALD--QCCDGITCKLKSEAQCASGACCD--QCRLRPKDYICRDSNNE-CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCG----RDA-------NEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSS 756          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLY----KRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKC---YGCIMATGI--ESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRH-ENERVLRLSEQFLNDEIVN----GYHCSAVRFDLDW-YLDDFGMVPNGVSCGSGRICWKSECV-LVNSIEQNRC-------NCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            +E  IIVD  M     G     +      + N  +L F   N   +V+ +E W ++Q  +     I   +  +     R       D    + GE       G +   ++C   R VG + D        ++  + H IGHN G+ HD   E+C C   +GCIMA  I  +     + +S CSK +    L++G   CLL++P       N + +  N             CGN VV++ E+CDCG  ++C  +  +CC+  TC     A CA G+CCD  +C L+    ICR+   E CDLPEYC+GE   CPSDV+K++G  C    TG   +C++G C +   +C+ +WG     ++  CY+  N +G +  +CG    R+A       N +   C  E   CG L C+  E + V    +Q  +  I++     + C A    +      + G+V +G  CG   IC    CV L   ++Q +C        C EHG C N   C C  G+   +C++
Sbjct:  272 IETAIIVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVC-TPRAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKP-------NEIELRRN-------------CGNKVVEEDEECDCGTFEECALD--QCCDGITCKLKSEAQCASGACCD--QCRLRPKDYICRDSNNE-CDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGHCG----RDA-------NEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSS 756          

Query:  754 GPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILMELQLYKRR---FINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY---GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWY-LDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNC 2247
            G  +VE+ ++VD+     FG  ++  +  R+  + N ++  +   NI   ++ LE+W +RD I ++   ++ +E  L  RR      K+HD  H I G +   +  G + + +MC  +      +D+ S N I ++  V HE+GHN G+ HD   C C    GCIM   I S  +  ++S CS+  +K+ L++   +CL+D P  N G++        G P          CGN  V+KGE+CDCG  ++C   +N CCN  TC  T GA CA G CC    C LK +G++CR      CDL EYC GES +CP D YK +G+ C+        +CY G+C + +  C+ LWG  A+V +D C+  N                   DR  K       S E   CGR++C   N       +  +N +    Y        LD    +D GMVP G  CG+ ++C+KS C+ ++      C+  C+  G CN+   CHC PG++ P C
Sbjct:  195 GQQIVEMVLVVDNTEYKKFG--SFKKIEERMMLVANHVDKLYRPLNIRVMLVGLEVWSQRDLIDVSSRPNLTLERFLKWRRDSLLQRKKHDNAHFITGIDFEGSTVGLATLYAMCSSSSSGAVNEDHNS-NPIAVASTVAHEMGHNLGMSHDDSSCGCSSNKGCIMGDTIGS-IYPDSFSTCSQSSLKAFLENYDTNCLIDVP--NEGQIY-------GGP---------VCGNAFVEKGEECDCGTVEEC---NNPCCNATTCRLTEGARCAHGECC--HNCQLKHTGSLCRK-SAHDCDLDEYCTGESAFCPEDDYKMNGLPCNY----NQGYCYNGQCPTHKEHCKMLWGSGADVDDDACFQYNV-----------------IDRTSK-------SAEHRKCGRIYCYGGNPFPKTNKKANVNVQSRTCY------MALDSSPTEDLGMVPTGTKCGTNKVCYKSLCLDISMYGTENCSNKCNNRGVCNHELKCHCDPGWAPPYC 640          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILME--LQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY--------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLS-EQFLNDEIV---NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW ++D+IK+       +   L    R  + + RHD    I+GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT   +C+        GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P ++           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G++CR   L  CDLPE+C G S +CP +V+ Q+G  C     G  S+CY G CAS   +CQ LWG  +  +  +C+  +NK+G+   NCG           Q  N +  PC K    CGR+ C+   ER L  S  + L   ++   + + C    F+L   + D  MV  G +CG  + C   +C  V +  +++ R  CH HG CN+  NCHC  G++ P+C
Sbjct:  204 IELVLVADHKEYLNYQKNNKTIIY-RMLDVANQVDWFYRPLNVRVALLGLEIWSDQDKIKVDKSPTETLNRFLDWRTRELLPRLRHDNAQLIMGESFDGTTVGMASQSSMCSKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTADRRCHCQNEPRLGGCIMEPSTGFMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPESL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCKLRVAGSVCRE-PLGECDLPEHCTGSSPYCPPNVFLQNGEPCK----GGSSYCYSGVCASLDDQCQMLWGQNSTRAPPICFSSVNKQGNKYGNCG-----------QMPNGSYIPCLKWDVHCGRIQCQGGGERPLLGSNAEILTTTVILNQSDFTCRGTYFNLGDDVSDPAMVLQGTACGPNKACVDQKCRDVSMFGVDECRSKCHGHGVCNSNKNCHCDEGWAPPDC 675          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILME--LQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY--------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLS-EQFLNDEIV---NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW ++D+IK+       +   L    R  + + RHD    I+GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT   +C+        GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P ++           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G++CR   L  CDLPE+C G S +CP +V+ Q+G  C     G  S+CY G CAS   +CQ LWG  +  +  +C+  +NK+G+   NCG           Q  N +  PC K    CGR+ C+   ER L  S  + L   ++   + + C    F+L   + D  MV  G +CG  + C   +C  V +  +++ R  CH HG CN+  NCHC  G++ P+C
Sbjct:  251 IELVLVADHKEYLNYQKNNKTIIY-RMLDVANQVDWFYRPLNVRVALLGLEIWSDQDKIKVDKSPTETLNRFLDWRTRELLPRLRHDNAQLIMGESFDGTTVGMASQSSMCSKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTADRRCHCQNEPRLGGCIMEPSTGFMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPESL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCKLRVAGSVCRE-PLGECDLPEHCTGSSPYCPPNVFLQNGEPCK----GGSSYCYSGVCASLDDQCQMLWGQNSTRAPPICFSSVNKQGNKYGNCG-----------QMPNGSYIPCLKWDVHCGRIQCQGGGERPLLGSNAEILTTTVILNQSDFTCRGTYFNLGDDVSDPAMVLQGTACGPNKACVDQKCRDVSMFGVDECRSKCHGHGVCNSNKNCHCDEGWAPPDC 722          

Query:  739 VKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRRFINKR--HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYG------CIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVN---SIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +K    P  VEL+++VD+     FG  + +++ +R+  ++N ++  +   NI   ++ LE+W ++DQI ++   +  L     +++  + KR  HD    + G +      G +   +MC  +   G  +D+ +QN + ++  + HE+GHN G+ HD + C C        CIM   + +  F   +S+CS  ++   L +    CLLD P S       V                  CGN  +D GE+CDCG  ++C+   N CC+P TC  T G+ CA G CC  + C +K + ++CR   +  CD+PEYC G SE CP + ++ +GI CS+       +CY G+C +    CQ+LWG  A+V+ D C+  N  G   ++CG    +  D          +PC++E   CG+++C   NE  +   +  +   +     C+      +   D   MVP G  CG  ++C+  +C  +N   SIE     C+  G CN++  CHC PG++ P C
Sbjct:  196 MKSFQTPRFVELFLVVDNTEYRNFG-SSMDSIRARMLEVVNHVDKLYRSLNIRVMLVGLEVWMKQDQIVVSVSSDDTLSRFIEWRKSNLLKRVKHDNAQFVTGIDFLGDTVGLANKFAMCAESS-AGVNQDH-NQNPLGLASTIAHEMGHNMGMSHDEDHCTCGSSVISSFCIMTERVGT-LFPEQFSDCSLEQLTVFLDNANPSCLLDTPSSYKLYSGPV------------------CGNAFLDPGEECDCGSVEECK---NPCCDPMTCKLTEGSRCAQGDCC--ENCQIKDAESLCR-ASINECDVPEYCTGLSEKCPENDFRMNGIPCSSG----QGYCYNGQCPTHLQHCQRLWGTGAKVAPDTCFYQNTLGKNDSHCG----KTKD--------GIRPCARENMFCGKIFCNEGNEFPVTGQKAVI---VTLRGQCNVAGDQTEE--DALSMVPTGTKCGHNKVCYDYKCQELNIYGSIEGCSLQCNGRGICNHKKQCHCDPGWAPPYC 662          

Query:  703 HQR-SKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFINK--RHDCLHAILGEN------LGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDI-SHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNG-YHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNR-C----NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            H R +  S F    + +P    VEL ++VD K   +    + N +   +  + N ++  F Q NI   +I L+I++       + N   +L     +++  ++   R+D    ++G+       LG A  G    AS  G           +S N +   S    HE+GHN G+ HD+  C C  CIMA    S S S  +S+CS +  + L++ G   CL + P                A  +I S+   +CGNG+++ GE+CDCG  ++C   +  CCN  TC FT G++CA GSCC  Q+C +  +GT CR   +  CDLPEYC GES +CPSD Y  DG+ C+N      ++C+ G+C +  ++C++++G  A  ++D C+ ++N  G+   NCG                  KPCS + ++CG+L C   N     L       +I  G   C    F++   + D   V  G  C  G++C    C   + ++Q+R C    +C  +G CN+R +CHC+ G+  PNC
Sbjct:  183 HSRYADMSMFLRKKRTLPQTKYVELALVVDQKRF-IIKNRSVNAVRDEMVQLANLLDTYFKQLNIRIALIGLKIFDTGNPFSVEGNAGDVLGRFVDWRKTTLSPQIRNDAAQLVVGQGAYPGGVLGMAFVGSVCSASTSG-------AISVFSDNNLQYYSTVAAHELGHNLGMSHDSNGCSCQ-CIMA---PSASGSTKFSDCSDNAFERLIQGGGGACLRNIP----------------AQDSIISV--PRCGNGILESGEECDCGTPQEC---NTTCCNAATCTFTKGSTCAAGSCC--QKCQIIVAGTPCRP-SINPCDLPEYCGGESPYCPSDFYMMDGLPCNNNA----AYCFEGRCQTFDYQCKQIFGSGATKADDKCFTNVNTYGNAFGNCGYS------------GTFPKPCSVQNAMCGKLQCLF-NSNNPPLGATVSVQKIEGGTITCMNADFNMGPDVPDPAYVKTGSVCAPGKLCANFTCFNSSVMDQSRKCDAQRDCSSNGVCNDRYHCHCNNGWGPPNC 663          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDE-NHILMELQLYKRRFIN-KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSE-QFLNDEIVNGY--HCSAVR-FDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL+I+ D  M  M    N  +   R+  I N ++  +   NI   +I LE+W ERDQ  + D+ N  L     +K++  + K+HD    I G        G + +  MC      G + D+ S+N I  +  + HEIGHNFG+ HD + C      +  GCIMA       F   +S CS+ ++ S  + G   CL + P +N                  + +M  KCGNG +++GEQCDCG  ++C   +N CCN   C    GA CA G CC  Q C LK +GT CR +   SCDLPE+C G++ +CPS+VY  DG SC+    GE ++CY G C + + +C  LWG  A V+ D C+ D+NK GD   NCG     +  R +  K      C+   + CG++ C+  +E+    S  +  N  I+NGY   C  V  + +     D G+V  G  CG G +C    C   +  E ++C   C+ HG CN+  NCHCH G++ P C
Sbjct:  208 MELFIVADYSMF-MKQNRNLGSTKQRVLEIANYVDKFYMSMNIKVALIGLEVWTERDQCDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGVTFKGTTIGMAPLEGMCTAENSGGVSMDH-SENAIGAAATMAHEIGHNFGMSHDNDGCCVEATPEQGGCIMAASTGH-PFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTN------------------DLVMGKKCGNGFLEEGEQCDCGEPEEC---TNPCCNANNCTLKAGAKCAHGECC--QDCRLKSAGTQCREMA-GSCDLPEFCTGDAPFCPSNVYMLDGSSCA---FGE-AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGDQYGNCG-----KNGRGQFVK------CTSRDAKCGKIQCQTSSEKPRDPSMVKVDNTIIINGYKMKCQGVHAYSMQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQCVSKCNGHGVCNSNRNCHCHSGWAPPYC 675          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDE-NHILMELQLYKRRFIN-KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSE-QFLNDEIVNGY--HCSAVR-FDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL+I+ D  M  M    N  +   R+  I N ++  +   NI   +I LE+W ERDQ  + D+ N  L     +K++  + K+HD    I G        G + +  MC      G + D+ S+N I  +  + HEIGHNFG+ HD + C      +  GCIMA       F   +S CS+ ++ S  + G   CL + P +N                  + +M  KCGNG +++GEQCDCG  ++C   +N CCN   C    GA CA G CC  Q C LK +GT CR +   SCDLPE+C G++ +CPS+VY  DG SC+    GE ++CY G C + + +C  LWG  A V+ D C+ D+NK GD   NCG     +  R +  K      C+   + CG++ C+  +E+    S  +  N  I+NGY   C  V  + +     D G+V  G  CG G +C    C   +  E ++C   C+ HG CN+  NCHCH G++ P C
Sbjct:  206 MELFIVADYSMF-MKQNRNLGSTKQRVLEIANYVDKFYMSMNIKVALIGLEVWTERDQCDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGVTFKGTTIGMAPLEGMCTAENSGGVSMDH-SENAIGAAATMAHEIGHNFGMSHDNDGCCVEATPEQGGCIMAASTGH-PFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTN------------------DLVMGKKCGNGFLEEGEQCDCGEPEEC---TNPCCNANNCTLKAGAKCAHGECC--QDCRLKSAGTQCREMA-GSCDLPEFCTGDAPFCPSNVYMLDGSSCA---FGE-AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGDQYGNCG-----KNGRGQFVK------CTSRDAKCGKIQCQTSSEKPRDPSMVKVDNTIIINGYKMKCQGVHAYSMQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQCVSKCNGHGVCNSNRNCHCHSGWAPPYC 673          

Query:  751 PGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDE-NHILMELQLYKRRFIN-KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSE-QFLNDEIVNGY--HCSAVR-FDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            PG + V L  +  ++   M    N  +   R+  I N ++  +   NI   +I LE+W ERDQ  + D+ N  L     +K++  + K+HD    I G        G + +  MC      G + D+ S+N I  +  + HEIGHNFG+ HD + C      +  GCIMA       F   +S CS+ ++ S  + G   CL + P +N                  + +M  KCGNG +++GEQCDCG  ++C   +N CCN   C    GA CA G CC  Q C LK +GT CR +   SCDLPE+C G++ +CPS+VY  DG SC+    GE ++CY G C + + +C  LWG  A V+ D C+ D+NK GD   NCG     +  R +  K      C+   + CG++ C+  +E+    S  +  N  I+NGY   C  V  + +     D G+V  G  CG G +C    C   +  E ++C   C+ HG CN+  NCHCH G++ P C
Sbjct:  163 PGHHRVSLEWLTATQF--MKQNRNLGSTKQRVLEIANYVDKFYMSMNIKVALIGLEVWTERDQCDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGVTFKGTTIGMAPLEGMCTAENSGGVSMDH-SENAIGAAATMAHEIGHNFGMSHDNDGCCVEATPEQGGCIMAASTGH-PFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTN------------------DLVMGKKCGNGFLEEGEQCDCGEPEEC---TNPCCNANNCTLKAGAKCAHGECC--QDCRLKSAGTQCREMA-GSCDLPEFCTGDAPFCPSNVYMLDGSSCA---FGE-AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGDQYGNCG-----KNGRGQFVK------CTSRDAKCGKIQCQTSSEKPRDPSMVKVDNTIIINGYKMKCQGVHAYSMQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQCVSKCNGHGVCNSNRNCHCHSGWAPPYC 634          

Query:  820 NYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDE-NHILMELQLYKRRFIN-KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSE-QFLNDEIVNGY--HCSAVR-FDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            N  +   R+  I N ++  +   NI   +I LE+W ERDQ  + D+ N  L     +K++  + K+HD    I G        G + +  MC      G + D+ S+N I  +  + HEIGHNFG+ HD + C      +  GCIMA       F   +S CS+ ++ S  + G   CL + P +N                  + +M  KCGNG +++GEQCDCG  ++C   +N CCN   C    GA CA G CC  Q C LK +GT CR +   SCDLPE+C G++ +CPS+VY  DG SC+    GE ++CY G C + + +C  LWG  A V+ D C+ D+NK GD   NCG     +  R +  K      C+   + CG++ C+  +E+    S  +  N  I+NGY   C  V  + +     D G+V  G  CG G +C    C   +  E ++C   C+ HG CN+  NCHCH G++ P C
Sbjct:  173 NLGSTKQRVLEIANYVDKFYMSMNIKVALIGLEVWTERDQCDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGVTFKGTTIGMAPLEGMCTAENSGGVSMDH-SENAIGAAATMAHEIGHNFGMSHDNDGCCVEATPEQGGCIMAASTGH-PFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTN------------------DLVMGKKCGNGFLEEGEQCDCGEPEEC---TNPCCNANNCTLKAGAKCAHGECC--QDCRLKSAGTQCREMA-GSCDLPEFCTGDAPFCPSNVYMLDGSSCA---FGE-AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGDQYGNCG-----KNGRGQFVK------CTSRDAKCGKIQCQTSSEKPRDPSMVKVDNTIIINGYKMKCQGVHAYSMQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQCVSKCNGHGVCNSNRNCHCHSGWAPPYC 623          

Query:  841 RISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDE-NHILMELQLYKRRFIN-KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSE-QFLNDEIVNGY--HCSAVR-FDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            R+  I N ++  +   NI   +I LE+W ERDQ  + D+ N  L     +K++  + K+HD    I G        G + +  MC      G + D+ S+N I  +  + HEIGHNFG+ HD + C      +  GCIMA       F   +S CS+ ++ S  + G   CL + P +N                  + +M  KCGNG +++GEQCDCG  ++C   +N CCN   C    GA CA G CC  Q C LK +GT CR +   SCDLPE+C G++ +CPS+VY  DG SC+    GE ++CY G C + + +C  LWG  A V+ D C+ D+NK GD   NCG     +  R +  K      C+   + CG++ C+  +E+    S  +  N  I+NGY   C  V  + +     D G+V  G  CG G +C    C   +  E ++C   C+ HG CN+  NCHCH G++ P C
Sbjct:  119 RVLEIANYVDKFYMSMNIKVALIGLEVWTERDQCDVNDDANDSLRSFLQWKQKLRSRKKHDNAQLITGVTFKGTTIGMAPLEGMCTAENSGGVSMDH-SENAIGAAATMAHEIGHNFGMSHDNDGCCVEATPEQGGCIMAASTGH-PFPRKFSRCSQQQLMSYFRKGGGMCLFNMPNTN------------------DLVMGKKCGNGFLEEGEQCDCGEPEEC---TNPCCNANNCTLKAGAKCAHGECC--QDCRLKSAGTQCREMA-GSCDLPEFCTGDAPFCPSNVYMLDGSSCA---FGE-AYCYNGMCLTHQQQCIHLWGSGAVVAPDFCFQDVNKAGDQYGNCG-----KNGRGQFVK------CTSRDAKCGKIQCQTSSEKPRDPSMVKVDNTIIINGYKMKCQGVHAYSMQEEEGDPGLVMTGTKCGDGMVCKDRRCQNASFFELDQCVSKCNGHGVCNSNRNCHCHSGWAPPYC 562          

Query:  259 LWLHLELKKQNQFP--ILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMP-------------GPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRRFINKR-HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV---NGYHCSAVRFDLDWYLD--DFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            LWL + L++    P  +LV       D +    + HK L    +    Y  +   +  +       ++   +    E   +   +S C+G+SG+  L +   Y Y   +   +T +             P       +QL+    W+    QR K S +   +  +P              P  +ELYI+ D  +  +    N N+   R+  + N ++      +I   +  LE+W E+D  ++T D N  L     ++R    +R HD    + G        G + +  +C      G + D+ S+  I  +  + HEIGH+ GLHHD E C      +  GC+M  ATG     F   +S CS+ ++++  + G   CL     SN      +             ++PS+CGNG ++ GE+CDCG  ++C    + CC    C    GA CA G CC   RC LK +GT CR    + CDLPE+C G S +CP+DVY  DG  C+        +C  G C +   +CQ+LWG  ++ + + C+  MN  G+   NCG           Q    +  PC++  ++CG+L C+      L      ++  I+       C       D +LD  D G+V  G  CG   +C    C    S E  RC   CH  G CN+  NCHC  G++ P C
Sbjct:   51 LWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTE-THYRPDGHPVVLSPNHTDHCQYHGRVRGFRE---SWVVLSTCSGMSGLIVLSSKVSY-YLQPRTPGDTKDF------------PTHEIFRMEQLFT---WRGV--QRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIVADHTLF-LLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDANETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDH-SELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATG---HPFPRVFSACSRRQLRTFFRKGGGPCL-----SNTSAPGLL-------------VLPSRCGNGFLEAGEECDCGSGQKC---PDPCCFAHNCSLRAGAQCAHGDCC--ARCLLKSAGTPCRPAATD-CDLPEFCTGTSPYCPADVYLLDGSPCAEG----RGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCG-----------QDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFC 681          

Query:  259 LWLHLELKKQNQFP--ILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMP-------------GPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRRFINKR-HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV---NGYHCSAVRFDLDWYLD--DFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            LWL + L++    P  +LV       D +    + HK L    +    Y  +   +  +       ++   +    E   +   +S C+G+SG+  L +   Y Y   +   +T +             P       +QL+    W+    QR K S +   +  +P              P  +ELYI+ D  +  +    N N+   R+  + N ++      +I   +  LE+W E+D  ++T D N  L     ++R    +R HD    + G        G + +  +C      G + D+ S+  I  +  + HEIGH+ GLHHD E C      +  GC+M  ATG     F   +S CS+ ++++  + G   CL     SN      +             ++PS+CGNG ++ GE+CDCG  ++C    + CC    C    GA CA G CC   RC LK +GT CR    + CDLPE+C G S +CP+DVY  DG  C+        +C  G C +   +CQ+LWG  ++ + + C+  MN  G+   NCG           Q    +  PC++  ++CG+L C+      L      ++  I+       C       D +LD  D G+V  G  CG   +C    C    S E  RC   CH  G CN+  NCHC  G++ P C
Sbjct:   51 LWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTE-THYRPDGHPVVLSPNHTDHCQYHGRVRGFRE---SWVVLSTCSGMSGLIVLSSKVSY-YLQPRTPGDTKDF------------PTHEIFRMEQLFT---WRGV--QRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIVADHTLF-LLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDANETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDH-SELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATG---HPFPRVFSACSRRQLRTFFRKGGGPCL-----SNTSAPGLL-------------VLPSRCGNGFLEAGEECDCGSGQKC---PDPCCFAHNCSLRAGAQCAHGDCC--ARCLLKSAGTPCRPAATD-CDLPEFCTGTSPYCPADVYLLDGSPCAEG----RGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCG-----------QDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFC 681          

Query:  220 WLRLNSINNPKYSLWLHLELKKQNQFPIL-VRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISF--IMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-----GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEI-VNG--YHCSAVRF-------DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            W    S    K+ L   L +  + +  IL + KNE+      T+T      Y+A+ N           T+T + E    +   + D+DE   +  ++S C GI G+  + ++  YI    +   N+ +   +  SE  ++PP            + DW      ++K+    M  +++     VELY++ D    A F  + ++   ++     I N ++  +   NI   ++ LE+W         EN    L     ++R+ +  K HD    I G +      G + + +MC   +  G + D+ S+N I ++  V HEIGHNFG+ HD+  C        GCIMA       F   +S C++ E+   L++G   CL     SNM             P         +CGNG ++ GE+CD     + E   N CCN   C    GA CA GSCC   +C L   GT CR  ++  CDLPE+C G+S  CP++ Y+ DG  C     G  ++CY G C + + +CQ+LWG  A  + D+C++ +N  GD   NCG  +           N   + CS   + CG++ C+    R L  +   ++  I +NG   HC            + +  + D G+V  G  CG   IC++ +C   +  E   C   C+ HG CNN  NCHC PG+S P C T
Sbjct:   51 WRTSESPGRGKHPLRAELRVMAEGRELILDLEKNEHLFAPAYTET-----CYTASGN---------PQTSTLKSEDHCFYHGTVRDVDE---SSVTLSTCRGIRGLIIVRSNLSYII---EPVPNSDSQHRIYRSEHLTLPPGNC-GFEHSGPTSKDWALQFTHQTKKQPRRMKREDLHSMKYVELYLVAD---YAEFQKNRHDQDATKRKLMEIANYVDKFYRSLNIRIALVGLEVWTHGDKCEVSENPYSTLWSFLSWRRKLLAQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVSMDH-SENAIGVASTVAHEIGHNFGMSHDSAHCCSASAADGGCIMAAATGH-PFPKVFSWCNRKELDRYLQTGGGMCL-----SNM-------------PDTRTLYGGRRCGNGYLEDGEECD---CGEEEECKNPCCNASNCTLKEGAECAHGSCC--HQCKLVAPGTQCRE-QVRQCDLPEFCTGKSPHCPTNYYQMDGTPCE----GGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGL-----------NGQYRKCSPRDAKCGKIQCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNKNCHCFPGWSPPFCNT 687          

Query:  337 IQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEH----------HKNHFSVSLCNGISG----------IEKLYNSSKY---IYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTD-ENHILMELQLYKRRFINKR--HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            IQ   + H       ++L+P  N+F   T     +KE   +S+  ++  H            +  +VS C G+ G          IE L+NSS +    Y     H+      V +         R  +    Q         ++  R +R+        +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW +R+ I +      +L     ++ +F+  R  HD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +    CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     G++CR    E CD+PEYCNG S++CP DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  +  +      +      G  C  V F L   + D GMV  G  C +G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ P+C T
Sbjct:   70 IQAQGKQHIIHLERNTDLLP--NDFVVYT----YDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSN---------RDTEKEGTQGDEEEHPSVTQLLRRRRAV-------LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGSCLLN------------------IPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVD--PCCEGSTCKLKSFAECAYGDCC--KDCQFLPGGSMCRGKTSE-CDVPEYCNGSSQFCPPDVFIQNGYPCQN----SKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFS------------GSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDT 675          

Query:  337 IQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEH----------HKNHFSVSLCNGISG----------IEKLYNSSKY---IYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTD-ENHILMELQLYKRRFINKR--HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            IQ   + H       ++L+P  N+F   T     +KE   +S+  ++  H            +  +VS C G+ G          IE L+NSS +    Y     H+      V +         R  +    Q         ++  R +R+        +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW +R+ I +      +L     ++ +F+  R  HD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +    CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     G++CR    E CD+PEYCNG S++CP DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  +  +      +      G  C  V F L   + D GMV  G  C +G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ P+C T
Sbjct:   70 IQAQGKQHIIHLERNTDLLP--NDFVVYT----YDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSN---------RDTEKEGTQGDEEEHPSVTQLLRRRRAV-------LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGSCLLN------------------IPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVD--PCCEGSTCKLKSFAECAYGDCC--KDCQFLPGGSMCRGKTSE-CDVPEYCNGSSQFCPPDVFIQNGYPCQN----SKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFS------------GSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDT 675          

Query:  259 LWLHLELKKQNQFP--ILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMP-------------GPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRRFINKR-HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQC------KCYGCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV---NGYHCSAVRFDLDWYLD--DFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            LWL + L++    P  +LV       D +    + HK L    +    Y  +   +  +       ++   +    E   +   +S C+G+SG+  L +   Y Y   +   +T +             P       +QL+    W+    QR K S +   +  +P              P  +ELYI+ D  +  +    N N+   R+  + N ++      +I   +  LE+W E+D  ++T D N  L     ++R    +R HD    + G        G + +  +C      G + D+ S+  I  +  + HEIGH+ GLHHD E C      +  GC+M  ATG     F   +S CS+ ++++  + G   CL     SN      +             ++PS+CGNG ++ GE+CDCG  ++C    + CC    C    GA CA G CC   RC LK +GT CR    + CDLPE+C G S +CP+DVY  DG  C+        +C  G C +   +CQ+LWG  ++ + + C+  MN  G+   NCG           Q    +  PC++  ++CG+L C+      L      ++  I+       C       D +LD  D G+V  G  CG   +C    C    S E  RC   CH  G CN+  NCHC  G++ P C
Sbjct:   51 LWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTE-THYRPDGHPVVLSPNHTDHCQYHGRVRGFRE---SWVVLSTCSGMSGLIVLSSKVSY-YLQPRTPGDTKDF------------PTHEIFRMEQLFT---WRGV--QRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIVADHTLF-LLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDANETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDH-SELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATG---HPFPRVFSACSRRQLRTFFRKGGGPCL-----SNTSAPGLL-------------VLPSRCGNGFLEAGEECDCGSGQKC---PDPCCFAHNCSLRAGAQCAHGDCC--ARCLLKSAGTPCRPAATD-CDLPEFCTGTSPYCPADVYLLDGSPCAEG----RGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCG-----------QDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFC 681          

Query:  220 WLRLNSINNPKYSLWLHLELKKQNQFPIL-VRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISF--IMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-----GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEI-VNG--YHCSAVRF-------DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            W    S    K+ L   L +  + +  IL + KNE+      T+T      Y+A+ N           T+T + E    +   + D+DE   +  ++S C GI G+  + ++  YI    +   N+ +   +  SE  ++PP            + DW      ++K+    M  +++     VELY++ D    A F  + ++   ++     I N ++  +   NI   ++ LE+W         EN    L     ++R+ +  K HD    I G +      G + + +MC   +  G + D+ S+N I ++  V HEIGHNFG+ HD+  C        GCIMA       F   +S C++ E+   L++G   CL     SNM             P         +CGNG ++ GE+CD     + E   N CCN   C    GA CA GSCC   +C L   GT CR  ++  CDLPE+C G+S  CP++ Y+ DG  C     G  ++CY G C + + +CQ+LWG  A  + D+C++ +N  GD   NCG  +           N   + CS   + CG++ C+    R L  +   ++  I +NG   HC            + +  + D G+V  G  CG   IC++ +C   +  E   C   C+ HG CNN  NCHC PG+S P C T
Sbjct:   51 WRTSESPGRGKHPLRAELRVMAEGRELILDLEKNEHLFAPAYTET-----CYTASGN---------PQTSTLKSEDHCFYHGTVRDVDE---SSVTLSTCRGIRGLIIVRSNLSYII---EPVPNSDSQHRIYRSEHLTLPPGNC-GFEHSGPTSKDWALQFTHQTKKQPRRMKREDLHSMKYVELYLVAD---YAEFQKNRHDQDATKRKLMEIANYVDKFYRSLNIRIALVGLEVWTHGDKCEVSENPYSTLWSFLSWRRKLLAQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVSMDH-SENAIGVASTVAHEIGHNFGMSHDSAHCCSASAADGGCIMAAATGH-PFPKVFSWCNRKELDRYLQTGGGMCL-----SNM-------------PDTRTLYGGRRCGNGYLEDGEECD---CGEEEECKNPCCNASNCTLKEGAECAHGSCC--HQCKLVAPGTQCRE-QVRQCDLPEFCTGKSPHCPTNYYQMDGTPCE----GGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGL-----------NGQYRKCSPRDAKCGKIQCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNKNCHCFPGWSPPFCNT 687          

Query:  748 MPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIK--LTDENHILMELQLYKRRFI--NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW    +   +     +L     ++ +F+   +RHD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +   +CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     GT+CR    E CD+PEYCNG S++C  DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  E  +      +      G  C  V F L   + D GMV  G  CG+G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ PNC T
Sbjct:  208 LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGNCLLN------------------IPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDP--CCEGSTCKLKSFAECAYGDCC--KDCRFLPGGTLCRGKTSE-CDVPEYCNGSSQFCQPDVFIQNGYPCQNN----KAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGF------------SGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCET 675          

Query:  220 WLRLNSINNPKYSLWLHLELKKQNQFPILVR---KNENKV----DWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN--HILMELQLYKRRFI-NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-----GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV-NG--YHCSAVRF----DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            W R +   +PK    L +   K ++ P+  +   K E +V      +  D + ++ L++ +     Y++  +  TTT ++E    +   + + +    +  ++S C GI G+  + ++  Y+     +    +  Q L        PP              DW     Q++K+    M  +++     VELY++ D  +       + +    ++  I N ++  +   NI   ++ LE+W    +    EN    L     ++R+ +  K HD    I G +      G + + +MC   +  G   D+ S+N I ++  + HE+GHNFG+ HD+  C        GCIMA       F   ++ C++ E+   L+SG   CL + P + M                       +CGNG ++ GE+CD     + E  +N CCN   C    GA CA GSCC   +C L   GT+CR  +   CDLPE+C G+S  CP++ Y+ DG  C     G  ++CY G C + + +CQ+LWG  A  + D+C++ +N  GD   NCG ++           N   + C+   + CG++ C+    R L  +   ++  I+ NG    C         + +  + D G+V  G  CG   IC++ +C   +  E   C   C+ HG CNN  NCHC PG++ P C T
Sbjct:   30 WTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETE---LSSVTLSTCRGIRGLITVSSNLSYVI----EPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADY-LEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDH-SENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAAT-GHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGG------------------RRCGNGYLEDGEECD---CGEEEECNNPCCNASNCTLRPGAECAHGSCC--HQCKLLAPGTLCRE-QARQCDLPEFCTGKSPHCPTNFYQMDGTPCE----GGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDM-----------NGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683          

Query:  337 IQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEH----------HKNHFSVSLCNGISG----------IEKLYNSSKY---IYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTD-ENHILMELQLYKRRFINKR--HDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEID-ISHAVLHEIGHNFGLHHDTEQ---CKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN---RCNCHEHGDCNNRGNCHCHPGFSAPNCTT 2253
            IQ   + H       ++L+P  N+F   T     +KE   +S+  ++  H            +  +VS C G+ G          IE L+NSS +    Y     H+      V +         R  +    Q         ++  R +R+        +P    VEL+I+VD +   M G  N   +   +  + N ++  +   NI   ++ LEIW +R+ I +      +L     ++ +F+  R  HD    +L +  G    G + + ++C  +   G   + + Q  ++  +  V HE+GHN G++HD  +   C    CIM +G    S S N+S+CS  + + L  +    CLL+                   P+  E+     CGN +VD GE+CDCG  K+CE +   CC   TC     A CA G CC  + C     G++CR    E CD+PEYCNG S++CP DV+ Q+G  C N      ++CY G C     +CQ ++G  A+ +   C+ ++N +GD   NCG                  K C+   ++CG+L C +  +  +      +      G  C  V F L   + D GMV  G  C +G+IC   +CV  + +  +   +  CH HG CN+  NCHC  G++ P+C T
Sbjct:   70 IQAQGKQHIIHLERNTDLLP--NDFVVYT----YDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSN---------RDTEKEGTQGDEEEHPSVTQLLRRRRAV-------LPQTRYVELFIVVDKERYDMMG-RNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGI--NVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSG---ASGSRNFSSCSAEDFEKLTLNKGGSCLLN------------------IPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVD--PCCEGSTCKLKSFAECAYGDCC--KDCQFLPGGSMCRGKTSE-CDVPEYCNGSSQFCPPDVFIQNGYPCQN----SKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFS------------GSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDT 675          

Query:  727 FHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKL-TDENHILMELQLYKRRFINKRHDCLHAILGENLG--TARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP----------------PSNMGKM-NAVAMEPNGAPRNIESLMP----SKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQ------RCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN------KRGDLVANCGLEIPREADRDRQPKNWNTKPCSK-ETSICGRLWCRHENERVLRL----SEQFLNDEIVNGYHCSAVRFD----------------LDWYL-----DDFGMVPNGVSCGSGRICWKSECVLVNSIEQN-RCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            FH P    P PY++ELY++VD K    + GD    L+ R++ +   +N  F+ FN+   +++LEIW+ D++++  +++H+L  L  +KR   + RHDCLHAI+ +  G  +  RG++    MC ++ CVG+T+D  S    + +  + HE+GH+ GL HDTE+C+C GCIMATG+E G+ + +WS CS  ++  LL+ GM  CL D P                P+++ ++ N   + P   P    +  P    S CGNG +D GE+CDCG  + C   +  CC+   C    GA CA G CC++       +C L+ +G+ CR  E  SCDLPE+C+G SEWCP+DVYK DG  C  +  G  S+C RG C S +  CQ LWGDTA  +   C + N       + D VANCG   P   +R    ++W +K C   E + CGRLWC H NE+ + L    S+Q ++ +  +G  C A+ +D                  W        D GMVP+G  C  G +C+   CV ++SI     C+C+ HG CNN GNCHC+PGF+ P+C
Sbjct:   98 FHQP--NHPAPYIIELYVVVDEKFVKSYRGDVVGILY-RVNTLFKHVNALFAPFNVRVVLVRLEIWKTDRVRMDVEDHHLLKTLANFKRTLTDVRHDCLHAIVADEGGQMSTMRGKASKEKMCTFSSCVGFTRDAPSMYPKETARTIAHELGHSLGLRHDTEECECQGCIMATGVEVGTTTMDWSLCSLRDLPVLLEHGMGSCLHDTPLDGHTSLLHASTTGAQPASVVRVFNGDQLRPGKVPEPRSTTPPQITESLCGNGKLDPGEECDCGTSETCPNATRACCDVYRCRLINGAECATGPCCEVTSTARGYQCRLRSAGSTCRP-ETGSCDLPEFCDGNSEWCPADVYKIDGEPCYTE-HGYKSYCVRGGCRSSQDWCQTLWGDTATHAGYGCTEYNIQLSKDGKADDVANCGKSRPIAEERWNDAQSWPSKVCKTWEDAQCGRLWCLHNNEKAMLLGWIQSQQRIDPQ--SGRSCLALVYDPVDVVPYSSVSRSLSDAAWGYTAAKSQDAGMVPDGTPCRRG-MCYNGSCVAISSIPMPITCSCNSHGVCNNLGNCHCNPGFAPPHC 659          

Query:  727 FHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKL-TDENHILMELQLYKRRFINKRHDCLHAILGENLG--TARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP----------------PSNMGKM-NAVAMEPNGAPRNIESLMP----SKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQ------RCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN------KRGDLVANCGLEIPREADRDRQPKNWNTKPCSK-ETSICGRLWCRHENERVLRL----SEQFLNDEIVNGYHCSAVRFD----------------LDWYL-----DDFGMVPNGVSCGSGRICWKSECVLVNSIEQN-RCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            FH P    P PY++ELY++VD K    + GD    L+ R++ +   +N  F+ FN+   +++LEIW+ D++++  +++H+L  L  +KR   + RHDCLHAI+ +  G  +  RG++    MC ++ CVG+T+D  S    + +  + HE+GH+ GL HDTE+C+C GCIMATG+E G+ + +WS CS  ++  LL+ GM  CL D P                P+++ ++ N   + P   P    +  P    S CGNG +D GE+CDCG  + C   +  CC+   C    GA CA G CC++       +C L+ +G+ CR  E  SCDLPE+C+G SEWCP+DVYK DG  C  +  G  S+C RG C S +  CQ LWGDTA  +   C + N       + D VANCG   P   +R    ++W +K C   E + CGRLWC H NE+ + L    S+Q ++ +  +G  C A+ +D                  W        D GMVP+G  C  G +C+   CV ++SI     C+C+ HG CNN GNCHC+PGF+ P+C
Sbjct:  132 FHQP--NHPAPYIIELYVVVDEKFVKSYRGDVVGILY-RVNTLFKHVNALFAPFNVRVVLVRLEIWKTDRVRMDVEDHHLLKTLANFKRTLTDVRHDCLHAIVADEGGQMSTMRGKASKEKMCTFSSCVGFTRDAPSMYPKETARTIAHELGHSLGLRHDTEECECQGCIMATGVEVGTTTMDWSLCSLRDLPVLLEHGMGSCLHDTPLDGHTSLLHASTTGAQPASVVRVFNGDQLRPGKVPEPRSTTPPQITESLCGNGKLDPGEECDCGTSETCPNATRACCDVYRCRLINGAECATGPCCEVTSTARGYQCRLRSAGSTCRP-ETGSCDLPEFCDGNSEWCPADVYKIDGEPCYTE-HGYKSYCVRGGCRSSQDWCQTLWGDTATHAGYGCTEYNIQLSKDGKADDVANCGKSRPIAEERWNDAQSWPSKVCKTWEDAQCGRLWCLHNNEKAMLLGWIQSQQRIDPQ--SGRSCLALVYDPVDVVPYSSVSRSLSDAAWGYTAAKSQDAGMVPDGTPCRRG-MCYNGSCVAISSIPMPITCSCNSHGVCNNLGNCHCNPGFAPPHC 693          

Query:  724 AFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTAR-RGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-------------------PSNMGKMNAVAMEPNGAPRNIES----LMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQR---------CSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN-------KRGDLVANCGLEIPREADRDRQPKNWNTKPCSK-ETSICGRLWCRHENERVLRLSEQFLNDEIVNGYH--CSAVRFD-LD-----------------W-----YLDDFGMVPNGVSCGSGRICWKSECVLVNSIE-QNRCNCHEHGDCNNRGNCHCHPGFSAPNCT 2250
             FH P +    PY+VELY++ D K  + F  D    + +R++ I   +N  FS+FN+ F ++ LEIWE++++ L  E+H L  L  +KR  +N RHDCL AILG++  T+  RG++    MC Y+ CV + +D       D +    HE+GH FGL HDTE C+C GCIMATG+E G+ +  WS CS  ++ +LL+ GM  CL D P                   PS++     +  +  G P  ++S    L  S CGNG +D GE+CDCG R+ C  E   CC+  TC F  GA CA G CCD+Q          C LK SGT+CR++   SCDLPEYC+G+SEWCP+DV+K DG +C  K  G  S+C RG C +    C+ LWG T   +   C   N       +  D VANCG   PR  +R ++   W +KPC     + CGRLWC H NE+ + L  Q     +       C A+ +D LD                 W        D GM P+G  C  G +C+   C+  + +  +  CNC+ +G CNN G+CHC+ G++ P+C 
Sbjct:   96 VFHRPGEN--APYIVELYVVTDEKFISSFSHD-IAQVVTRVNNIFKVVNSLFSRFNVQFVIVGLEIWEKNRVNLEAEDHFLRTLASFKRTEVNTRHDCLFAILGDDDQTSTTRGRANSQVMCKYSSCVSFVRDSLYMEVNDTARTAAHELGHTFGLRHDTEDCECQGCIMATGVEFGTATMEWSPCSIRDMPNLLRFGMGACLHDIPVQSHTSLLPRQLRLIDVNGPSSIHTYTVINTQ-RGTPELLQSTPLSLKMSLCGNGKLDPGEECDCGTRETCPKEVRACCDVTTCKFREGAECASGPCCDIQTVSGDPSKTICKLKASGTVCRDVG-NSCDLPEYCDGQSEWCPADVFKTDGETCYTK-EGYRSNCIRGGCNAPDEWCRVLWGPTGTAAGPGCIGYNLIRDPNSQSIDEVANCGRLRPRSDERWKEIDQWPSKPCYDWPDAECGRLWCMHRNEKAMLLGWQESQRRVDPHTQRTCVALVYDPLDPLQHAEITSQTGFPGPGWDHTASVTQDAGMTPDGTPCQRG-LCYNGSCISRDELLFRKTCNCNSNGVCNNLGHCHCNIGYAPPDCV 664          

Query:  724 AFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTAR-RGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-------------------PSNMGKMNAVAMEPNGAPRNIES----LMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQR---------CSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN-------KRGDLVANCGLEIPREADRDRQPKNWNTKPCSK-ETSICGRLWCRHENERVLRLSEQFLNDEIVNGYH--CSAVRFD-LD-----------------W-----YLDDFGMVPNGVSCGSGRICWKSECVLVNSIE-QNRCNCHEHGDCNNRGNCHCHPGFSAPNCT 2250
             FH P +    PY+VELY++ D K  + F  D    + +R++ I   +N  FS+FN+ F ++ LEIWE++++ L  E+H L  L  +KR  +N RHDCL AILG++  T+  RG++    MC Y+ CV + +D       D +    HE+GH FGL HDTE C+C GCIMATG+E G+ +  WS CS  ++ +LL+ GM  CL D P                   PS++     +  +  G P  ++S    L  S CGNG +D GE+CDCG R+ C  E   CC+  TC F  GA CA G CCD+Q          C LK SGT+CR++   SCDLPEYC+G+SEWCP+DV+K DG +C  K  G  S+C RG C +    C+ LWG T   +   C   N       +  D VANCG   PR  +R ++   W +KPC     + CGRLWC H NE+ + L  Q     +       C A+ +D LD                 W        D GM P+G  C  G +C+   C+  + +  +  CNC+ +G CNN G+CHC+ G++ P+C 
Sbjct:   96 VFHRPGEN--APYIVELYVVTDEKFISSFSHD-IAQVVTRVNNIFKVVNSLFSRFNVQFVIVGLEIWEKNRVNLEAEDHFLRTLASFKRTEVNTRHDCLFAILGDDDQTSTTRGRANSQVMCKYSSCVSFVRDSLYMEVNDTARTAAHELGHTFGLRHDTEDCECQGCIMATGVEFGTATMEWSPCSIRDMPNLLRFGMGACLHDIPVQSHTSLLPRQLRLIDVNGPSSIHTYTVINTQ-RGTPELLQSTPLSLKMSLCGNGKLDPGEECDCGTRETCPKEVRACCDVTTCKFREGAECASGPCCDIQTVSGDPSKTICKLKASGTVCRDVG-NSCDLPEYCDGQSEWCPADVFKTDGETCYTK-EGYRSNCIRGGCNAPDEWCRVLWGPTGTAAGPGCIGYNLIRDPNSQSIDEVANCGRLRPRSDERWKEIDQWPSKPCYDWPDAECGRLWCMHRNEKAMLLGWQESQRRVDPHTQRTCVALVYDPLDPLQHAEITSQTGFPGPGWDHTASVTQDAGMTPDGTPCQRG-LCYNGSCISRDELLFRKTCNCNSNGVCNNLGHCHCNIGYAPPDCV 664          

Query:  733 MPV---KEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKL-TDENHILMELQLYKRRFINKRHDCLHAILGENL-GTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP------------PSNMGKMNAVAME------------PNGAPRNIESLMPSK-----CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQR------------CSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN---KRG---DLVANCGLEIPREADRDRQPKNWNTKPC-SKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYH--CSAVRFDLDW----------------------------YLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQN-RCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            MP+    + P P ++ELY++VD  +  +F  D Y+ L  R++ +++ +N  ++ FNI   V++LE+W +D+ +L  +E+HIL  L  +KR     RHDCLHA+LGE   G++ +G++   +MC ++RCVGYT+D  S + ++ +  + HE+GHNFGL HDTE+CKC  CIMATG+E G+    WS CS  ++  LL  GM  CL D P            P N    +AV +             P  +PR   S   S      CGNGV+D GE+CDCG R+ C  +   CC+ + C    G+ CAGG CC +QR            C L  +GT+CRN E  +CDLPEYC+G S WCPSDV+K DGI C  +  G  S+C RG C      C+ LWG     ++  C+D N    +G   D VANCG   P   +R   PK+W    C S + + CGRLWC H+NE+ + L         ++     CSA+ +D  W                               D GMVP+G  C  G +C+   CV  + I    +C+C  HG CNN G+CHC PGF  P C
Sbjct:   18 MPILHRPDQPSPRILELYMVVDEALVNLFNRD-YDMLIFRVNSLISHVNALYAPFNIAIVVVRLELWMQDRDRLNIEEHHILPTLAQFKRMHTTVRHDCLHALLGERKEGSSNKGKANSHTMCVFSRCVGYTRDSPSSDILETARTMAHELGHNFGLRHDTEECKCQNCIMATGVEFGTNLMAWSPCSMRDLSVLLDYGMGACLHDTPVRTVVAIGAYNQPKNSTVSSAVRVYDWTTQSSSELHLPALSPRYRHSSRRSTATDRLCGNGVLDPGEECDCGTRESCPIQLQDCCDAQRCRLKPGSECAGGPCCRIQRVPATQFSLERFQCRLAPAGTVCRN-ESGNCDLPEYCDGLSGWCPSDVFKADGIPCWTE-EGTESYCARGGCREADSWCRVLWGKRGRRAHPHCFDENHGIPKGVPVDPVANCGKRKPLSEERWEDPKSWPGIRCPSVQDAECGRLWCHHQNEKAMILGWIESQTRYLSSVEQSCSALVYDPVWPASDPSTWDASKKRQTNLNVAGVGILSAVTQDAGMVPDGTPCSRG-MCYNGSCVPHSEIRARFQCDCRGHGICNNLGHCHCDPGFHPPFC 602          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENH---ILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKCY------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW      L D+N    +   L+   R  + + RHD    ++GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT    C+C       GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P  +           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G +CR   L  CDLPE+C G S +CP +V+ Q+G  C + +    S+CY G CAS   +CQ+LWG  A  +  VC+  +NK G+   NCG           Q  N +  PCS     CGR+ C+   +R L  S   +    V      + C  + FDL   + D  MV  G +C  G++C    C  V V  +E+ R  C+ HG CN+  NCHC  G++ P+C
Sbjct:  276 IELVLVADHKEYLNYQRNNKTIIY-RMLDVANQVDWFYRTLNVRVALLGLEIWSDQDKILVDKNPTDTLNRFLEWRTRDLLPRLRHDNAQLVMGESFDGTTVGMASQSSMCTKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTSDRHCECQNEPRLGGCIMEPSTGSMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPEKL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCRLRVAGWMCRE-PLGECDLPEFCTGTSPFCPPNVFLQNGEPCQDGV----SYCYSGVCASLDDQCQQLWGANATRAPPVCFSSVNKEGNKYGNCG-----------QTANGSYIPCSNADVHCGRIQCQGGGDRPLLGSNAQIRTARVRLNLKNFTCRGLYFDLGDGVSDPAMVAQGTACAPGKVCLDQRCQDVSVFGVEECRDKCNGHGVCNSNKNCHCDVGWAPPHC 747          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENH---ILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTE--QCKCY------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW      L D+N    +   L+   R  + + RHD    ++GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT    C+C       GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P  +           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G +CR   L  CDLPE+C G S +CP +V+ Q+G  C + +    S+CY G CAS   +CQ+LWG  A  +  VC+  +NK G+   NCG           Q  N +  PCS     CGR+ C+   +R L  S   +    V      + C  + FDL   + D  MV  G +C  G++C    C  V V  +E+ R  C+ HG CN+  NCHC  G++ P+C
Sbjct:  276 IELVLVADHKEYLNYQRNNKTIIY-RMLDVANQVDWFYRTLNVRVALLGLEIWSDQDKILVDKNPTDTLNRFLEWRTRDLLPRLRHDNAQLVMGESFDGTTVGMASQSSMCTKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTSDRHCECQNEPRLGGCIMEPSTGSMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPEKL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCRLRVAGWMCRE-PLGECDLPEFCTGTSPFCPPNVFLQNGEPCQDGV----SYCYSGVCASLDDQCQQLWGANATRAPPVCFSSVNKEGNKYGNCG-----------QTANGSYIPCSNADVHCGRIQCQGGGDRPLLGSNAQIRTARVRLNLKNFTCRGLYFDLGDGVSDPAMVAQGTACAPGKVCLDQRCQDVSVFGVEECRDKCNGHGVCNSNKNCHCDVGWAPPHC 747          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENH---ILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKCY------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW      L D+N    +   L+   R  + + RHD    ++GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT    C+C       GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P  +           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G +CR   L  CDLPE+C G S +CP +V+ Q+G  C + +    S+CY G CAS   +CQ+LWG  A  +  VC+  +NK G+   NCG           Q  N +  PCS     CGR+ C+   +R L  S   +    V      + C  + FDL   + D  MV  G +C  G++C    C  V V  +E+ R  C+ HG CN+  NCHC  G++ P+C
Sbjct:  276 IELVLVADHKEYLNYQRNNKTIIY-RMLDVANQVDWFYRTLNVRVALLGLEIWSDQDKILVDKNPTDTLNRFLEWRTRDLLPRLRHDNAQLVMGESFDGTTVGMASQSSMCTKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTSDRHCECQNEPRLGGCIMEPSTGSMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPEKL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCRLRVAGWMCRE-PLGECDLPEFCTGTSPFCPPNVFLQNGEPCQDGV----SYCYSGVCASLDDQCQQLWGANATRAPPVCFSSVNKEGNKYGNCG-----------QTANGSYIPCSNADVHCGRIQCQGGGDRPLLGSNAQIRTARVRLNLKNFTCRGLYFDLGDGVSDPAMVAQGTACAPGKVCLDQRCQDVSVFGVEECRDKCNGHGVCNSNKNCHCDVGWAPPHC 747          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN---HILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKCY------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW      L D+N    +   L+   R  + + RHD    ++GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT    C+C       GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P  +           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G +CR   L  CDLPE+C G S +CP +V+ Q+G  C + +    S+CY G CAS   +CQ+LWG  A  +  VC+  +NK G+   NCG           Q  N +  PCS     CGR+ C+   +R L  S   +    V      + C  + FDL   + D  MV  G +C  G++C    C  V V  +E+ R  C+ HG CN+  NCHC  G++ P+C
Sbjct:  276 IELVLVADHKEYLNYQRNNKTIIY-RMLDVANQVDWFYRTLNVRVALLGLEIWSDQDKILVDKNPTDTLNRFLEWRTRDLLPRLRHDNAQLVMGESFDGTTVGMASQSSMCTKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTSDRHCECQNEPRLGGCIMEPSTGSMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPEKL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCRLRVAGWMCRE-PLGECDLPEFCTGTSPFCPPNVFLQNGEPCQDGV----SYCYSGVCASLDDQCQQLWGANATRAPPVCFSSVNKEGNKYGNCG-----------QTANGSYIPCSNADVHCGRIQCQGGGDRPLLGSNAQIRTARVRLNLKNFTCRGLYFDLGDGVSDPAMVAQGTACAPGKVCLDQRCQDVSVFGVEECRDKCNGHGVCNSNKNCHCDVGWAPPHC 747          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENH---ILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDT--EQCKCY------GCIM--ATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP-PSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAG-GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC--VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +EL ++ D K    +  +N   ++ R+  + NQ++  +   N+   ++ LEIW      L D+N    +   L+   R  + + RHD    ++GE+      G +  +SMC  +R  G   D+   + + ++  V HE+GHN G+ HDT    C+C       GCIM  +TG   G     +S+CS+ ++   L  G   CL + P P  +           G PR         CGN  V+KGE+CDCG   +C   ++ CCN  TC    GA C+  G CC  + C L+ +G +CR   L  CDLPE+C G S +CP +V+ Q+G  C + +    S+CY G CAS   +CQ+LWG  A  +  VC+  +NK G+   NCG           Q  N +  PCS     CGR+ C+   +R L  S   +    V      + C  + FDL   + D  MV  G +C  G++C    C  V V  +E+ R  C+ HG CN+  NCHC  G++ P+C
Sbjct:  276 IELVLVADHKEYLNYQRNNKTIIY-RMLDVANQVDWFYRTLNVRVALLGLEIWSDQDKILVDKNPTDTLNRFLEWRTRDLLPRLRHDNAQLVMGESFDGTTVGMASQSSMCTKDRSGGVNVDHLV-SVLGVASTVAHELGHNLGMSHDTSDRHCECQNEPRLGGCIMEPSTGSMPGQL---FSSCSERDLSLSLLHGGGMCLFNVPQPEKL----------LGGPR---------CGNLYVEKGEECDCGLLDEC---NDPCCNASTCKLVPGAQCSSDGICC--ENCRLRVAGWMCRE-PLGECDLPEFCTGTSPFCPPNVFLQNGEPCQDGV----SYCYSGVCASLDDQCQQLWGANATRAPPVCFSSVNKEGNKYGNCG-----------QTANGSYIPCSNADVHCGRIQCQGGGDRPLLGSNAQIRTARVRLNLKNFTCRGLYFDLGDGVSDPAMVAQGTACAPGKVCLDQRCQDVSVFGVEECRDKCNGHGVCNSNKNCHCDVGWAPPHC 747          

Query:  703 HQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRR--FINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY--------GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSK-CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENER-VLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHG 2190
            H R KRSA     K M     VEL I+ D+        D       R+  + N ++  +   NI   ++ +E+W E D+  +T D +  L E   ++++     K+HD    + G +      G + + SMC   +  G   D+ + N + ++  + HE+GHNFG++HDT + +C+        GCIMA       F   +S+CS  ++ S L  G   CL + P                   ++  L   K CGNG V+ GEQCDCG  ++C+   N CCN   C    GA CA G CC  Q C LK SGT CR+    +CDLPEYCNG S  CP +VY  DG  C     G+ ++CY G C +   +C  LWG  ++ + ++C+ ++N  GD   NCG          +  K    K C      CG++ C+  + R V+  +   ++  I         C      L   + D G+V  G  CG G+IC+   C  V+ ++   C+  C+ HG
Sbjct:   64 HARLKRSAL----KNMK---YVELIIVADNAKYNRESKD-LTRTKQRMIDVANHVDKYYRSLNIRIALVGVEVWTESDRSAVTVDASSTLYEFLDWRKKQLLTRKKHDNAQLVTGISFQGTTIGMAPLMSMCSAEQSGGVNMDH-AVNPVGLAATMAHEMGHNFGMNHDTPERRCHCQANSEQGGCIMAPSTGH-PFPSKFSSCSIRDLDSSLSKGGGMCLYNMP-------------------DVRDLYGGKRCGNGYVEDGEQCDCGEIEECD---NPCCNANNCTLRAGAECAHGMCC--QDCQLKPSGTRCRD-PTNTCDLPEYCNGGSPHCPPNVYLLDGYPCH----GKEAYCYNGMCLTHEQQCVTLWGSGSKPAPEICFANVNSAGDQYGNCG----------KDSKAVYMK-CKASDVKCGKIQCQGGSTRPVIGTNAVSIDTNIAVPGGGTVLCRGTHVYLGDDMLDPGLVLTGTKCGEGKICYNRHCQNVSILKTGNCDTKCNGHG 530          

Query:  703 HQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLT-DENHILMELQLYKRR--FINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY--------GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSK-CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENER-VLRLSEQFLNDEIV----NGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN--CHEHG 2190
            H R KRSA     K M     VEL I+ D+        D       R+  + N ++  +   NI   ++ +E+W E D+  +T D +  L E   ++++     K+HD    +  + + T   G + + SMC   +  G   D+ + N + ++  + HE+GHNFG++HDT + +C+        GCIMA    S   +  +S+CS  ++ S L  G   CL + P                   ++  L   K CGNG V+ GEQCDCG  ++C+   N CCN   C    GA CA G CC  Q C LK SGT CR+    +CDLPEYCNG S  CP +VY  DG  C     G+ ++CY G C +   +C  LWG  ++ + ++C+ ++N  GD   NCG          +  K    K C      CG++ C+  + R V+  +   ++  I         C      L   + D G+V  G  CG G+IC+   C  V+ ++   C+  C+ HG
Sbjct:   67 HARLKRSAL----KNMK---YVELIIVADNAKYNRESKD-LTRTKQRMIDVANHVDKYYRSLNIRIALVGVEVWTESDRSAVTVDASSTLYEFLDWRKKQLLTRKKHDNAQLVTKKRVSTTI-GMAPLMSMCSAEQSGGVNMDH-AVNPVGLAATMAHEMGHNFGMNHDTPERRCHCQANSEQGGCIMA---PSTGGNDKFSSCSIRDLDSSLSKGGGMCLYNMP-------------------DVRDLYGGKRCGNGYVEDGEQCDCGEIEECD---NPCCNANNCTLRAGAECAHGMCC--QDCQLKPSGTRCRD-PTNTCDLPEYCNGGSPHCPPNVYLLDGYPCH----GKEAYCYNGMCLTHEQQCVTLWGSGSKPAPEICFANVNSAGDQYGNCG----------KDSKAVYMK-CKASDVKCGKIQCQGGSTRPVIGTNAVSIDTNIAVPGGGTVLCRGTHVYLGDDMLDPGLVLTGTKCGEGKICYNRHCQNVSILKTGNCDTKCNGHG 530          

Query:  748 MPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW---ERDQIKLTDENHILMELQLYKRRFIN----KRHDCLHAILGEN----LGTARRGQSEM-ASMCGYNRCVGYTKDYYSQNEIDISHAVL-HEIGHNFGLHHDTEQ-CKC---YGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSEC----VLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTN 2256
            +P    VEL  I+D+ +       N       ++ + N ++  +   +I    + + +    E   +    ++   +  +  K R  N    KRHD    I        LG A  G   + A+  G N  VG        + + ++ +VL HE+GHN G+ HD  + C C   +GCIM   + S   +  +S CS+ +++ L+    A CLL+ P ++                  E+L P  CG+ ++D GE+CDCG  ++C+   NKCC+  TC    GA CA GSCC  + C     G +CR  +   CDLPE+C+G +  CP D + Q+G  C N      ++CY G C +   +C+ +WG  +  ++D C+  +N +G+   NCG  +P          +   K CS+    CG+L C  +N + L +     N        C AV ++L   + D  +V +G  C  G +C+  +C    VL  SI+     C+ HG+ NN  +CHC  G++ P+C++ 
Sbjct:  145 LPSTRYVELLFILDNTLYTGQYQSNKTLAVHDMAELANLVDSYYRVLDIRVVPVGVHVLSAQEEAAVMAEGDSAGTVLGKFLKWRESNLDSMKRHDNAQLITARQFQSILGMAYVGTVCLRATSGGINTLVG--------SSVLMTASVLSHELGHNLGMSHDDNRTCSCAAEHGCIMGAVMGSPPATV-FSGCSEDDLEGLVNG--ATCLLNVPKAD------------------EALRPPVCGDKMLDAGEECDCGSPEECD---NKCCDARTCRLRSGARCAYGSCC--KDCQFVGQGEVCRAAQ-GVCDLPEFCSGSAASCPDDSFLQNGHPCQNAA----AYCYNGVCQTYTSQCEAIWGPESNPASDECFLTVNTKGNEFGNCG-TVP----------SGKYKSCSRRDVKCGKLICESKNNQPL-IGHTVPNFAFYG--QCRAVDYNLGSDVPDPALVQSGTKCADGMVCFNQQCQDARVLNYSIDYTSI-CNGHGEHNNHKHCHCAEGWAPPDCSST 615          

Query:  766 VELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDEN-----HILMELQLYKRRFIN--KRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYG-CIMATGIESGSFSFNWSNCSKHEIKSL-LKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCN----CHEHGDCNNRGNCHCHPGFSAPNC 2247
            VE  ++V + +       N +++ + ++ I+N ++L +   NI   ++ L +   ++  L  ++      ++ +   +++   N   RHDC H +  E+ G A  G + + ++C  +   G      ++    ++  V HE+GHN G+ HD   C+C   CIM  G+ +   +  +S CS  + ++L L      CLL+ P  N                  E      CG+ +VDKGE CDCG  ++C   +N CC   TC   V A CA G CC  + C +   G  CR   + +CDLPEYCNG S++C +D + Q+G  C N      ++CY G C +  ++C+ +WG  A   +D CY  +N +G+   NCG           Q  N     C+     CG+L C +   + L +          +   C+AV F+    + D G+V  G  CGS  +C  ++C     +    CN    C  HG CNN  NCHC+ G++ P+C
Sbjct:   77 VEFVLVVGATLYKNRYNSNRSSMVTDVAAIVNLVDLDYKTINIRVVLVGLHLMTTEEQALVVQDGDAAGSVVGKFAKWRQTNYNILGRHDCGHLLTWESYG-AIVGMAYVGTICSRSSSAG-IASMPTRQIPSVAAVVAHEMGHNLGMSHDRSPCQCSTPCIMNAGLVNPPPT-AFSQCSTDDFENLILVQHGGSCLLNVPTPN------------------EEFRQPVCGDSIVDKGEDCDCGSPQEC---NNPCCEASTCRLKVNAECAYGLCC--KECKIMGQGESCRP-SVGACDLPEYCNGSSQFCYTDTFIQNGYPCQN----SSAYCYNGVCLTLDYQCRSIWGGNAVSGSDNCYLIVNTKGNEFGNCG-----------QGTNGYIT-CTTANIKCGKLVCENTPSKPLIVDAP----NFASYQGCNAVSFNYGTDIPDPGLVQPGTKCGSNSVCMDNQCQNATVVMGTLCNTTQKCSGHGVCNNNLNCHCNDGYAPPDC 537          

Query:  853 IMNQINLAF-SQFNIYFTVIQLEIW-ERDQIKL-TDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFG-LHHDTEQ------CKC----YGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYD-MNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYH------CSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC-------NCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            I+N ++  +  Q N    ++ +E W + ++I + TD    L     Y+R+      D  H + G    ++  G +    +C   R  G   +Y +   + ++ A    IG N G L H+++       C+C    YGCIM   +        +S CS  E +  L++G   CL ++P                     +     +CGNG V+ GE+CDCG   +C    +KCC  + C FT GA C+ G CC    C     G  CR+   E CDLPE C G+S  CP +V+KQDG SC NK  G    CY G+C +R  +C+ +WGD    S   CYD +N  G    NCG          R+  +W    CSK   +CG L C + + R  +L E   +   V+  H      CS     L     D G V +G  CG   IC   +C  + ++  + C        C  HG C+N   C C   +   +C+
Sbjct:  166 IVNMVDAIYKEQLNTRVVLVSMETWTDENRITVSTDPLQTLRAFMKYRRQSPRTDGDTAHLLSGLMFESSHSGVAYFGGVCSLQR-GGGVNEYGNVGAMVVTLA--QGIGQNLGMLWHNSKAAARGGGCQCTDIWYGCIME--VTGQMLPMRFSQCSIDEYQEFLQAGGGACLFNKP--------------------TQLFEQPECGNGFVELGEECDCGSPTECSEGWDKCC--KKCTFTHGAICSSGLCCAPNSCQFITRGEECRHAVGE-CDLPETCPGDSVQCPPNVHKQDGYSC-NKDQGR---CYIGQCKTREKQCKYIWGDKGMSSERQCYDKLNIEGTEKGNCG----------RKEDSWLQ--CSKHDVLCGFLLCTNVS-REPQLGELQGDSVKVSIRHNGHLLECSGGHIMLA-DGSDLGYVEDGTPCGPDVICLDHKCQPLQALNLSGCPSVIQGTACSGHGVCSNEARCVCERHWVGNDCS 613          

Query: 1168 IGHNFGLHHDTEQCKCY--------GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANC 1860
            +GHN G+ HD     C         GCIM +G+     +  WS CS+   K  ++ G+  CL ++P    G  +A+                  CGNG  ++GE+CDCG  ++C+  S+ CCN  TC  T G+ C  G CC   +C L  +G  CR  ++  CDLPE C+G+SE CP++ Y  +G SC +        C+ G C +  ++C+ LWG       +VCY +N +G    +C
Sbjct:    1 MGHNLGMSHDESVVGCTCEDKDVNKGCIM-SGVARSIPATKWSKCSEDSFKEFMERGLDPCLFNQPLMLFG--DAI------------------CGNGFKEEGEECDCGTAEECKRYSDDCCNSTTCKLTAGSECMDGPCC--FKCKLSPAGKECRE-KVSECDLPEVCDGKSELCPANRYVYNGKSCGDG----KGFCFNGVCPTLDNQCETLWGLGVTSGPEVCYTINMKGTYSGSC 211          

Query: 1426 CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANC 1860
            CGNG  ++GE+CDCG     E  S+ CCN  TC  T G+ C  G CC   +C L  +G  CR  ++  CDLPE C+G+SE CP++ Y  +G SC +        C+ G C +  ++C+ LWG       +VCY +N +G    +C
Sbjct:    2 CGNGFKEEGEECDCGTA---ERYSDDCCNSTTCKLTAGSECMDGPCC--FKCKLSPAGKECRE-KVSECDLPEVCDGKSELCPANRYVYNGKSCGDG----KGFCFNGVCPTLDNQCETLWGLGVTSGPEVCYTINMKGTYSGSC 136          

Query:  823 YNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQI--KLTDEN-HILMELQLYK--------RRFINKRHDCLHAILG------ENL--GTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVL-HEIGHNFGLHHDTEQCKCY------GCIMATGIESGSFSFN--WSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCN----PETCLFTVGASCAG--GSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISC 1707
            Y N F+  ++ +      +S + I F V ++ I++   +  K  D+N  I + L L            F+    D  + ILG       N   G   R          YN  V   K Y       +S     HE+GH FG  HD E   C         +M +   SG    N  +S+CS   I+  +     D                   P  +   I +  P  CGN +++  EQCDCG    C+AE   CCN    P+ C  T+ A+C+   G CC  + C    +   CRN     C     C+G S  CP  VY+ D   C
Sbjct:  231 YKNAFNTTNYDL------YSPYGITFRVKKMVIYDEQDVPDKYKDDNLAIDVMLNLLSSDDHSDVCEAFMFTDRDFDNGILGLAWIGKPNFLGGICSRYSKVGGQYISYNTGVVTLKLYRLFTPPKVSEVTFAHELGHGFGSEHDPEDGDCSPGGKDGNYVMYSKATSGDRPNNDVFSSCSLKAIRDNINDKRGD-------------------PKYSGCFISADTPI-CGNRIIEGNEQCDCGDENSCKAEGG-CCNPPGHPQACRLTLPATCSPSQGPCCG-RDCRYVGNDISCRN--KTDCLDKAMCSGSSVECPKSVYQPDNTVC 529          

Query:  766 VELYIIVDSKMAAMFGGDNYNNL-----------FSRISFIMNQINLAFSQFNIYFT--------------VIQLEIW-ERDQIKL-TDENHILMELQLYKRRFI--NKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEP 1341
            +E  ++VD KMA   G D                FS  S   N INL  S+  I  T              +     W ER+   L  DENH      L+ R  I  +K   C      + LG AR        MC +       +D    N + +   + HE GH+ G++HD   C     +M+T       +F+WS+CS++ +K  L S  + CL D+P
Sbjct:  205 IESLVVVDPKMANFHGEDAAKQYALAACNIVSAKFSDSSLGENPINLVVSRMQILTTQQPGLIINHHASNTLESFGKWAERNNNPLDNDENHYDYAT-LFTRYNICKDKNQPC------DTLGLAR-----TRGMCSFPSSASVNQD----NGLMLGMTLAHETGHSMGINHDGGDCADGENVMSTFAPGKPAAFSWSSCSRNYLKQFLASDDSKCLDDQP 409          

Query: 1078 SMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDC---GGRKQCEAESNKCCNPETCLFTVGASCA--GGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGE-SEW 1668
            + CGY+    Y+        +  + ++ HE+ HN G+ HDT  C   G IM +G  SG  +F WS CS+ E+K        +C  + PP  +                    +PS+     +D  EQC      G K+C    ++C   +      G SC   G    D   C  +K     R +E+    LP   +G+ S+W
Sbjct:  354 AFCGYSCESRYSASVNDDQGLQTAFSIAHEMAHNLGVDHDTGDCS--GHIMTSGQPSGPDAFTWSKCSRKELKQSFAG--HECYDNLPPKLIK-------------------IPSRPPGFNIDADEQCTMMYGRGYKRCPITQHQC---DQMFCYRGNSCVARGSPPVDGTACGWRKWCMKGRCVEV-GASLPPPVDGQWSDW 529          

Query:  475 IDEHHKNHFSVSLCNGISGI----EKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXV--PPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPY-LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWE-RDQIKLTDENHILMELQLYKRR---FINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKC------YGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHC-SAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHE----HGDCNNRGNCHCHPGFSAPNC 2247
            I     +  SV +C+GISG     ++L+          + H    + Q+  SS   S     R+A++  QQ    A    SR +RSK          +P P   VEL ++ D+   +  G +       RI   +N ++  + + NI   ++ LEIW  RD I +  +    ++  L  R+    +  +HD    + G +  T   G +   +MC  N   G     + +N I ++  + HE+GHNFGL HD + C C        C+M   I++G F   +S+CS  ++   +      CL  E P + G + ++A+ P             +CG+ ++D GE+CDCG  ++C   +N CC   TC  T G+ CA G CC  + C  K +G++CR    E CDLPEYC G+S+ CP D ++ +G  C  +  G    C+ G+C +R H C +L+G+ A+V  D+C++ NK+G+  ANCG        RDR        PCS     CG ++C +  + +    +  + +       C +AV  D    LD   MVPNG +CG  +IC    C  + S+ +NR +C +    +G CN++  CHC PG++ P C
Sbjct:  107 IQGEEDSSVSVQICSGISGFLRAQQQLFLIEPLGQTMEEDHAVYRSEQLKRSSGQHSTCGLKRSAEDRKQQGPQPAALFMSRSRRSK---------SVPDPQKFVELVVVADNAEYSRHGKETRQ----RILLAVNHVDKLYRRLNIRIVLVGLEIWSYRDLINVDLKAGTTLDNFLSWRQSDLLLRVQHDNAQFVTGTDFETDTVGLANKFAMCTPNS--GAVNQDHHENLIGLASTIAHEMGHNFGLSHDEDGCLCGSDDSSTDCVMTEKIKNGLFPEFFSSCSLRQLDEFMLRAQPSCL--ELPGS-GSVKSIALGP-------------RCGDAILDAGEECDCGTSEEC---NNACCEASTCRLTAGSQCAHGQCC--ENCQFKVTGSVCRKPASE-CDLPEYCTGDSQDCPEDAFEMNGKPCYTQTQG---FCFDGRCPTREHHCWRLFGEGAKVGPDLCFNSNKKGEDGANCG--------RDRS----GPIPCSAGNVKCGSMFCVNGGDSI--TGKLAVYNVFRFNLECRAAVEDDRSRNLD---MVPNGATCGPKKICLNHRCEDI-SVYENREDCAKKCNNNGVCNHKNQCHCDPGWAPPYC 661          

Query:  211 PNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYI-------------YFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWE-RDQIKLTD--ENHILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKC------YGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHE-NERVLRLSEQFLNDEIVNGYHCS-AVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIE---QNRCN--CHEHGDCNNRGNCHCHPGFSAPNC 2247
            P+V     SI+  KY+L  HLE   +N++  LV KN                 ++ TS    YS++ + +T+T  +     +  +I  ++E   +  S+ LC+G+ G   L N    I               N K H +     V +           +       Y+         Q     +     ++   P  VEL ++VD+     +G      + SR+  I N ++  +    +   ++ L IW  RDQI+++   +  ++  ++  +R  + K +HD    I G +      G +   +MC  N   G   + ++ N I ++  + HE+GHN GL HDTE C C       GCIMA  +    +   +S+CSK +++  L+     CLLD P ++            G P          CGN  ++ GE+CDCG  K+C   +N CCN  TC    GA CA G CC    C LK +G ICR  +   CDL EYC G S  CP+D + Q+G+ C++       +CY G C SR+  C++LWG  AEV+ D C+                     R    + ++ + C+ +   CG L+C       V  +   ++   + NG  C+ A     D Y  D GMVP G  CG+  +C+ + C  + +I+   +N C+  C+ HG CN+   CHC PG++ P C
Sbjct:   42 PDVLQYSLSIDRGKYTL--HLE---KNRY--LVGKN-----------------FTVTS----YSDDGAQVTSTPDLRVHCYYHGHIVGVEE---SSASIELCSGMKGFVTLRNRMYLIEPLASEEAEMLDNRGNPKAHSDEGPHAVYNYKHLRRKRSSCSHGNTTTFYDHGARPSGVFQLGSLKSRAQTKQQADKPRTVELVVVVDNSEYKKYGSKK--TIESRVLEIANHVDKLYRPVGVRVMLVGLIIWSNRDQIEVSSNSDTTLIRFIEWRQRNLVQKIKHDNAQLITGIDFEGTTVGLANTNAMCTSNS--GAINEDHNTNAIGVASTIAHEMGHNLGLTHDTENCVCGSYTSKRGCIMAESL-GIVYPEQFSSCSKLQLRRFLEEYNPACLLDTPSTS---------RIFGGP---------VCGNAFLEPGEECDCGSAKEC---TNPCCNATTCKLNAGAQCAEGECC--HNCQLKPTGIICRP-KAGDCDLAEYCTGFSAACPADTFAQNGLRCNSG----KGYCYNGNCPSRQEHCRRLWGPDAEVAADECF--------------------SRHGSCRKFSQR-CAAKDQFCGTLFCSGGWTFPVTSMKSYYI---VGNGVTCNEATMKPEDNYPSDLGMVPTGTKCGNNMVCYNNRCEDIRNIKAYGKNDCSSKCNNHGVCNHESKCHCDPGWAPPFC 662          

Query:  211 PNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYI-------------YFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWE-RDQIKLTD--ENHILMELQLYKRRFINK-RHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKC------YGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHE-NERVLRLSEQFLNDEIVNGYHCS-AVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIE---QNRCN--CHEHGDCNNRGNCHCHPGFSAPNC 2247
            P+V     SI+  KY+L  HLE   +N++  LV KN                 ++ TS    YS++ + +T+T  +     +  +I  ++E   +  S+ LC+G+ G   L N    I               N K H +     V +           +       Y+         Q     +     ++   P  VEL ++VD+     +G      + SR+  I N ++  +    +   ++ L IW  RDQI+++   +  ++  ++  +R  + K +HD    I G +      G +   +MC  N   G   + ++ N I ++  + HE+GHN GL HDTE C C       GCIMA  +    +   +S+CSK +++  L+     CLLD P ++            G P          CGN  ++ GE+CDCG  K+C   +N CCN  TC    GA CA G CC    C LK +G ICR  +   CDL EYC G S  CP+D + Q+G+ C++       +CY G C SR+  C++LWG  AEV+ D C+                     R    + ++ + C+ +   CG L+C       V  +   ++   + NG  C+ A     D Y  D GMVP G  CG+  +C+ + C  + +I+   +N C+  C+ HG CN+   CHC PG++ P C
Sbjct:   77 PDVLQYSLSIDRGKYTL--HLE---KNRY--LVGKN-----------------FTVTS----YSDDGAQVTSTPDLRVHCYYHGHIVGVEE---SSASIELCSGMKGFVTLRNRMYLIEPLASEEAEMLDNRGNPKAHSDEGPHAVYNYKHLRRKRSSCSHGNTTTFYDHGARPSGVFQLGSLKSRAQTKQQADKPRTVELVVVVDNSEYKKYGSKK--TIESRVLEIANHVDKLYRPVGVRVMLVGLIIWSNRDQIEVSSNSDTTLIRFIEWRQRNLVQKIKHDNAQLITGIDFEGTTVGLANTNAMCTSNS--GAINEDHNTNAIGVASTIAHEMGHNLGLTHDTENCVCGSYTSKRGCIMAESL-GIVYPEQFSSCSKLQLRRFLEEYNPACLLDTPSTS---------RIFGGP---------VCGNAFLEPGEECDCGSAKEC---TNPCCNATTCKLNAGAQCAEGECC--HNCQLKPTGIICRP-KAGDCDLAEYCTGFSAACPADTFAQNGLRCNSG----KGYCYNGNCPSRQEHCRRLWGPDAEVAADECF--------------------SRHGSCRKFSQR-CAAKDQFCGTLFCSGGWTFPVTSMKSYYI---VGNGVTCNEATMKPEDNYPSDLGMVPTGTKCGNNMVCYNNRCEDIRNIKAYGKNDCSSKCNNHGVCNHESKCHCDPGWAPPFC 697          

Query:  475 IDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYN-AADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILM--ELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-------GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSK-CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSH--CYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNG---YHCSAVRF----DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +  H  +   +S C+G  G+  L NSS   Y      E +    + S+          A   +   +N ++DW  S H R KR+ +             ELYI+ D++M      D Y    +RI  I N ++  +   NI   +I LE+W +RDQ  ++ E +  +   LQ  ++    K+HD    + G        G + +  MC      G T D+ S   I  +  + HE+GHNFG+ HD + C C        GC+MA       F   +S CSK ++ S  + G   CL + P                   N++ L+  K CGNG V+ GE+CDCG   + E  +N CCN   C    GA CA G CC  Q C LK++GT+CR     +CDLPEYC G S +CP++VY  DG +C      +Y H  CY G C + + +C +LWG  A+ ++D C+ D+N  G+   NCG +           ++ N   C K  + CG++ C    ++    +   ++  I  G     C         D    L D G+V  G  CG G++C    C   +  E   C   CH +G CN+ GNCHC+ G++ P C
Sbjct:  106 VRGHPHSWVGISTCSGFRGLISL-NSSDTFYLEPLSDEASVRHSLRSTKHLPITGGSCAHPHHTSAFNLSSDWFPSHHSRVKRNTWGTT-------KYTELYIVADNEMFKRQNRD-YEKTKTRIMEIANYVDKFYRALNIRVPLIGLEVWTDRDQCIISKEPNATLWSFLQWRQKLKSRKKHDNAQLLTGVIFKGTTIGMAPLEGMCSLENSGGITVDH-SDLSIGAAATMAHEMGHNFGMSHDHDGC-CVEATANQGGCVMAAATGH-PFPRVFSRCSKRDLDSYFQKGGGMCLYNMP-------------------NMKDLVGGKKCGNGFVEDGEECDCG---EPEECTNNCCNANNCTLREGAQCAHGVCC--QNCKLKEAGTMCRG-PAGTCDLPEYCTGASPYCPANVYLLDGSAC------QYGHAYCYNGMCLTHQQQCLQLWGYGAQPAHDACFEDVNAAGNAFGNCGKD-----------EHGNYVKCDKSDAKCGKIQCHSAAKKPKGTNAVSIDTTIKTGGREVKCRGTYVYSTQDGQGDLPDPGLVVTGTKCGEGKVCRDRRCQNASFTELQGCIGRCHGNGVCNSNGNCHCNRGWAPPFC 666          

Query:  475 IDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYN-AADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIW-ERDQIKLTDENHILM--ELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCY-------GCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSK-CGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSH--CYRGKCASRRHRCQKLWGDTAEVSNDVCY-DMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNG---YHCSAVRF----DLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRC--NCHEHGDCNNRGNCHCHPGFSAPNC 2247
            +  H  +   +S C+G  G+  L NSS   Y      E +    + S+          A   +   +N ++DW  S H R KR+ +             ELYI+ D++M      D Y    +RI  I N ++  +   NI   +I LE+W +RDQ  ++ E +  +   LQ  ++    K+HD    + G        G + +  MC      G T D+ S   I  +  + HE+GHNFG+ HD + C C        GC+MA       F   +S CSK ++ S  + G   CL + P                   N++ L+  K CGNG V+ GE+CDCG   + E  +N CCN   C    GA CA G CC  Q C LK++GT+CR     +CDLPEYC G S +CP++VY  DG +C      +Y H  CY G C + + +C +LWG  A+ ++D C+ D+N  G+   NCG +           ++ N   C K  + CG++ C    ++    +   ++  I  G     C         D    L D G+V  G  CG G++C    C   +  E   C   CH +G CN+ GNCHC+ G++ P C
Sbjct:  132 VRGHPHSWVGISTCSGFRGLISL-NSSDTFYLEPLSDEASVRHSLRSTKHLPITGGSCAHPHHTSAFNLSSDWFPSHHSRVKRNTWGTT-------KYTELYIVADNEMFKRQNRD-YEKTKTRIMEIANYVDKFYRALNIRVPLIGLEVWTDRDQCIISKEPNATLWSFLQWRQKLKSRKKHDNAQLLTGVIFKGTTIGMAPLEGMCSLENSGGITVDH-SDLSIGAAATMAHEMGHNFGMSHDHDGC-CVEATANQGGCVMAAATGH-PFPRVFSRCSKRDLDSYFQKGGGMCLYNMP-------------------NMKDLVGGKKCGNGFVEDGEECDCG---EPEECTNNCCNANNCTLREGAQCAHGVCC--QNCKLKEAGTMCRG-PAGTCDLPEYCTGASPYCPANVYLLDGSAC------QYGHAYCYNGMCLTHQQQCLQLWGYGAQPAHDACFEDVNAAGNAFGNCGKD-----------EHGNYVKCDKSDAKCGKIQCHSAAKKPKGTNAVSIDTTIKTGGREVKCRGTYVYSTQDGQGDLPDPGLVVTGTKCGEGKVCRDRRCQNASFTELQGCIGRCHGNGVCNSNGNCHCNRGWAPPFC 692          

Query:  118 NDLSCNNEKYRYRLFNGNNLAELNKNSLTFCPNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNXXXXXXXXXXXXKFNHQSRXXXXXXXXXXXXXXXXXXXXXXXYHYRNRTWPYFVSFIKCPNYK--------FRRSKLLILCHKGIGKGHPKSSEIRNNESNVTLLSELRSIEGGSPDHLATVEIINAKNIEIRKVEKDNSQYSKPKRPVVINIDAKYISNEXXXXXXXXXXXXXXDRTFPVPMSVKEKAKYLENTK--EKLDFENHKCNEKVAIEKKPLNTHNFIKPEILSEKPTKNSNKTLNTVKPPILSAKPQKSVQSAKSPPVLGXXXXXXXXXXXXXXXTTEKPKKISNLEINSHETKSIPHKSVAIAPNIQENKSITEQPRGQNESLINKINKSKYTGKSVKPFKFQISEPTLDHSTNALASPTCQPFKPAREKGPDILSHIKPPKTEGDIKVFTNSKDEQNNIKLARPLKFQISQPRLEQTTCTDATQDLPVVDKTLTRTVAPHKVFKNDPSKAVNFRN 3621
            NDLSCNNEKYRYRLFNGNNLAELNKNSLTF PNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKN FSVSLCNGISGIEKLYNSSK+IYFNSKKHENTTNVQVLSSSESESVPPRTADN YQQLYNAAD KFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSN+GKMNAVAMEPNGAPR IESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFD+DWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNGDGGSIDSGPPPKFNHQSRLIITVILIVMIVILTIFVILVFIYHYRNRTWPYFVSFIKCPNYK        + + K  ++ +          ++  +NESN  L S        SPD    V                         P+ +   AKY+ N                         KEK  + EN K  EK+  E    N    I+ + L           SEKPTKNSNKTLNTVKPPILSAKPQKSVQSAKSPPVLGAKPQKPPAISPAPPITTEKPKKISNLEINSHETKSIPHKSVAIAPNIQ+NKSITEQPRGQNESL+NKINKSKYTGKSVKPFKFQISEPTLDHSTNALASPTCQPFKPAREKGPDILSHIKPPKTEGDIKVFTNSKDEQNNIKLARPLKFQISQPRLEQTTCTDAT+DLPVVDKTLTRTVAPHKVFKNDPSKAVNFRN
Sbjct:   17 NDLSCNNEKYRYRLFNGNNLAELNKNSLTFGPNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNQFSVSLCNGISGIEKLYNSSKFIYFNSKKHENTTNVQVLSSSESESVPPRTADNFYQQLYNAADRKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNIGKMNAVAMEPNGAPRYIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDMDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNGDGGSIDSGPPPKFNHQSRLIITVILIVMIVILTIFVILVFIYHYRNRTWPYFVSFIKCPNYKKVEKDNSQYSKPKRPVVIN--------IDAKYISNESNKPLYSPKSP---KSPDRTFPV-------------------------PMSVKEKAKYLEN------------------------TKEKLDF-ENHKCNEKVAIEKKPLNTHSVIKPEIL-----------SEKPTKNSNKTLNTVKPPILSAKPQKSVQSAKSPPVLGAKPQKPPAISPAPPITTEKPKKISNLEINSHETKSIPHKSVAIAPNIQQNKSITEQPRGQNESLVNKINKSKYTGKSVKPFKFQISEPTLDHSTNALASPTCQPFKPAREKGPDILSHIKPPKTEGDIKVFTNSKDEQNNIKLARPLKFQISQPRLEQTTCTDATRDLPVVDKTLTRTVAPHKVFKNDPSKAVNFRN 1122          

Query:  118 NDLSCNNEKYRYRLFNGNNLAELNKNSLTFCPNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNHFSVSLCNGISGIEKLYNSSKYIYFNSKKHENTTNVQVLXXXXXXXVPPRTADNLYQQLYNAADWKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNXXXXXXXXXXXXKFNHQSRXXXXXXXXXXXXXXXXXXXXXXXYHYRNRTWPYFVSFIKCPNYKFRRSKLLILCHKGIGKGHPKSSEIRNNESNVTLLSELRSIEGGSP 2580
            NDLSCNNEKYRYRLFNGNNLAELNKNSLTF PNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKN FSVSLCNGISGIEKLYNSSK+IYFNSKKHENTTNVQVLSSSESESVPPRTADN YQQLYNAAD KFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSN+GKMNAVAMEPNGAPR IESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFD+DWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNGDGGSIDSGPPPKFNHQSRLIITVILIVMIVILTIFVILVFIYHYRNRTWPYFVSFIKCPNYKFRRSKLLILCHKGIGKGHPKSSEIRNNESNVTLLSELRSIEGG P
Sbjct:   17 NDLSCNNEKYRYRLFNGNNLAELNKNSLTFGPNVWLRLNSINNPKYSLWLHLELKKQNQFPILVRKNENKVDWIQTDTQSHKCLYSATSNLIPYSNEFSSMTTTERIEKEIKFVSNIADIDEHHKNQFSVSLCNGISGIEKLYNSSKFIYFNSKKHENTTNVQVLSSSESESVPPRTADNFYQQLYNAADRKFSRHQRSKRSAFHMPVKEMPGPYLVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNIGKMNAVAMEPNGAPRYIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMNKRGDLVANCGLEIPREADRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDMDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCTTNGDGGSIDSGPPPKFNHQSRLIITVILIVMIVILTIFVILVFIYHYRNRTWPYFVSFIKCPNYKFRRSKLLILCHKGIGKGHPKSSEIRNNESNVTLLSELRSIEGGIP 837          

Query:  763 LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN-KRGDLVANCGLEIP-READRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            +  LY+IVDS +         N    RI  I   IN  +    I F +I +EIW+ + I+++ E +IL EL++YK++ +N  HDCLH  LG      R+G++E  +MC  + CVGYT D  +QN    ++ V HE+ HNFGL HDT  C C  CIMATG+E  S   +WS+CS  +IKSLLK G          S    +     +P    +   S+  S CGNG+V+ GEQCDCG R  CE    KCCN  TC F+  + CA GSCC+ + C L  +GTICRN     CDL EYCNG+ E CP D+++QDG  C  K   + +HC+ G+C     +C+ LWG T+ VS+  CYD N +      NCGL +   +        +W TKPC K  SICGRLWC H+NE+    + QF          C A RF++DW   D GMVP+G  CG+  +C   +CV ++ I    C+C  +G C N+  C C   +  PNC+
Sbjct:   40 IFTLYLIVDSNLYQQSQESTEN----RIQSIFILINKIYLPLGIQFQIICIEIWKENLIEISQEEYILEELKIYKKKSVNINHDCLHLFLGSTYFFTRQGRAEFTTMCSKSSCVGYTVDSITQNIKYTAYTVSHELAHNFGLTHDTSDCGCENCIMATGVEFSSRKLDWSSCSISQIKSLLKLGFPCHSHLAQFSTTIFVKISRRQPMMKSKRTSSINISICGNGIVENGEQCDCGKRSDCE----KCCNFLTCKFSANSQCASGSCCNTEICKLYPTGTICRN-STTFCDLTEYCNGQDENCPIDIFRQDGTECLTKFNNK-AHCFGGQCKDHGTQCRFLWGQTSNVSHSSCYDENTEENHAFKNCGLIVTLNDKTYFDSFLDWPTKPCQKSNSICGRLWCIHDNEK----TNQF----------CEASRFEVDWNNRDIGMVPDGAVCGNKMVCSNGDCVPLDGIFDKSCHCFNNGICTNQKKCQCFQQYLPPNCS 513          

Query:  763 LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN-KRGDLVANCGLEIP-READRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            +  LY+IVDS +         N    RI  I   IN  +    I F +I +EIW+ + I+++ E +IL EL++YK++ +N  HDCLH  LG      R+G++E  +MC  + CVGYT D  +QN    ++ V HE+ HNFGL HDT  C C  CIMATG+E  S   +WS+CS  +IKSLLK G          S    +     +P    +   S+  S CGNG+V+ GEQCDCG R  CE    KCCN  TC F+  + CA GSCC+ + C L  +GTICRN     CDL EYCNG+ E CP D+++QDG  C  K   + +HC+ G+C     +C+ LWG T+ VS+  CYD N +      NCGL +   +        +W TKPC K  SICGRLWC H+NE+    + QF          C A RF++DW   D GMVP+G  CG+  +C   +CV ++ I    C+C  +G C N+  C C   +  PNC+
Sbjct:   44 IFTLYLIVDSNLYQQSQESTEN----RIQSIFILINKIYLPLGIQFQIICIEIWKENLIEISQEEYILEELKIYKKKSVNINHDCLHLFLGSTYFFTRQGRAEFTTMCSKSSCVGYTVDSITQNIKYTAYTVSHELAHNFGLTHDTSDCGCENCIMATGVEFSSRKLDWSSCSISQIKSLLKLGFPCHSHLAQFSTTIFVKISRRQPMMKSKRTSSINISICGNGIVENGEQCDCGKRSDCE----KCCNFLTCKFSANSQCASGSCCNTEICKLYPTGTICRN-STTFCDLTEYCNGQDENCPIDIFRQDGTECLTKFNNK-AHCFGGQCKDHGTQCRFLWGQTSNVSHSSCYDENTEENHAFKNCGLIVTLNDKTYFDSFLDWPTKPCQKSNSICGRLWCIHDNEK----TNQF----------CEASRFEVDWNNRDIGMVPDGAVCGNKMVCSNGDCVPLDGIFDKSCHCFNNGICTNQKKCQCFQQYLPPNCS 517          

Query:  763 LVELYIIVDSKMAAMFGGDNYNNLFSRISFIMNQINLAFSQFNIYFTVIQLEIWERDQIKLTDENHILMELQLYKRRFINKRHDCLHAILGENLGTARRGQSEMASMCGYNRCVGYTKDYYSQNEIDISHAVLHEIGHNFGLHHDTEQCKCYGCIMATGIESGSFSFNWSNCSKHEIKSLLKSGMADCLLDEPPSNMGKMNAVAMEPNGAPRNIESLMPSKCGNGVVDKGEQCDCGGRKQCEAESNKCCNPETCLFTVGASCAGGSCCDLQRCSLKKSGTICRNIELESCDLPEYCNGESEWCPSDVYKQDGISCSNKITGEYSHCYRGKCASRRHRCQKLWGDTAEVSNDVCYDMN-KRGDLVANCGLEIP-READRDRQPKNWNTKPCSKETSICGRLWCRHENERVLRLSEQFLNDEIVNGYHCSAVRFDLDWYLDDFGMVPNGVSCGSGRICWKSECVLVNSIEQNRCNCHEHGDCNNRGNCHCHPGFSAPNCT 2250
            +  LY+IVDS +         N    RI  I   IN  +    I F +I +EIW+ + I+++ E +IL EL++YK++ +N  HDCLH  LG      R+G++E  +MC  + CVGYT D  +QN    ++ V HE+ HNFGL HDT  C C  CIMATG+E  S   +WS+CS  +IKSLLK G          S    +     +P    +   S+  S CGNG+V+ GEQCDCG R  CE    KCCN  TC F+  + CA GSCC+ + C L  +GTICRN     CDL EYCNG+ E CP D+++QDG  C  K   + +HC+ G+C     +C+ LWG T+ VS+  CYD N +      NCGL +   +        +W TKPC K  SICGRLWC H+NE+    + QF          C A RF++DW   D GMVP+G  CG+  +C   +CV ++ I    C+C  +G C N+  C C   +  PNC+
Sbjct:   40 IFTLYLIVDSNLYQQSQESTEN----RIQSIFILINKIYLPLGIQFQIICIEIWKENLIEISQEEYILEELKIYKKKSVNINHDCLHLFLGSTYFFTRQGRAEFTTMCSKSSCVGYTVDSITQNIKYTAYTVSHELAHNFGLTHDTSDCGCENCIMATGVEFSSRKLDWSSCSISQIKSLLKLGFPCHSHLAQFSTTIFVKISRRQPMMKSKRTSSINISICGNGIVENGEQCDCGKRSDCE----KCCNFLTCKFSANSQCASGSCCNTEICKLYPTGTICRN-STTFCDLTEYCNGQDENCPIDIFRQDGTECLTKFNNK-AHCFGGQCKDHGTQCRFLWGQTSNVSHSSCYDENTEENHAFKNCGLIVTLNDKTYFDSFLDWPTKPCQKSNSICGRLWCIHDNEK----TNQF----------CEASRFEVDWNNRDIGMVPDGAVCGNKMVCSNGDCVPLDGIFDKSCHCFNNGICTNQKKCQCFQQYLPPNCS 513