GRB2 associated binding protein-1

Overview
NameGRB2 associated binding protein-1
Smed IDSMED30022438
Length (bp)621
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of GRB2 associated binding protein-1 (SMED30022438) t-SNE clustered cells

Violin plots show distribution of expression levels for GRB2 associated binding protein-1 (SMED30022438) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GRB2 associated binding protein-1 (SMED30022438) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GRB2 associated binding protein-1 (SMED30022438) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30022438

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymal cellSMED30022438SMESG000035904.1 dd_Smed_v4_4400_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of GRB2 associated binding protein-1 vs. TrEMBL
Match: I1ZIF9 (GRB2 associated binding protein-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 83.9593 bits (206), Expect = 5.902e-17
Identity = 56/144 (38.89%), Postives = 77/144 (53.47%), Query Frame = 3 
Query:   81 RKNSQKIKPQSKICYPLNTNHYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAI 512
            R ++ K K      YPL+   YEI K+GYL+KSPPL          F  K+++RYFI++      N+I+FDYF +H     P G+IDL Q T I   V IE  N + IET     NGS   R YYLT  +   +  +++W+  I
Sbjct:    6 RSSTTKQKLSVDRIYPLDPADYEIHKQGYLIKSPPLKKVRRSSLPIFQAKYRKRYFIIH-TNNTNNKIYFDYFCKHEDLKYPKGSIDLNQITKISHPVHIEDQNRLLIETD----NGS-NRREYYLTSVNN-DEDEMQSWIYHI 142
[Close]
BLAST of GRB2 associated binding protein-1 vs. TrEMBL
Match: A0A4E0RYK4 (PH domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_005329 PE=4 SV=1)

HSP 1 Score: 58.151 bits (139), Expect = 2.606e-6
Identity = 42/140 (30.00%), Postives = 68/140 (48.57%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFL--------------KKWKRRYFILYRAK-EYENEIFFDYFKRHHLTHIP-TGTIDLMQCTNIKMNVKIEK-SNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIV 515
            +++ EG L KSPP N D       FL              K+W++R+ +LY+ +   + E++FDY+K   +TH    G +DL  C  I  NV+I K SN  +I+T + +       R+YY        Q  +  W+ ++V
Sbjct:   14 QVLMEGLLTKSPP-NQDNGSHSGNFLRDLHCMGFTPPFMRKRWRQRHCVLYKVRGGKKTEVYFDYYK--DVTHTKLKGRVDLRNCECIVDNVEIGKWSNVFSIQTMHKD-----RSRVYYFAAET---QELMAKWVNSLV 142
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BLAST of GRB2 associated binding protein-1 vs. TrEMBL
Match: A0A5K4F2S9 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 57.7658 bits (138), Expect = 3.923e-6
Identity = 42/120 (35.00%), Postives = 61/120 (50.83%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRA-KEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWL 503
            ++I  GYL+KS  +      ++      WKRRYFILY+   + + EIFFDY+K   +T    G +DL  C  I  NV I +  A +I T    FNG+   RIYY       + + +  W+
Sbjct:   12 DVIICGYLMKSRRI----ELLRKLLWNDWKRRYFILYKVHSQNKTEIFFDYYKDETVTKFK-GRVDLEHCECIVENVNIGQPCAFSISTL---FNGN--KRIYYFIA---ANNKIMSDWV 118
[Close]
BLAST of GRB2 associated binding protein-1 vs. Ensembl Medaka
Match: gab1 (GRB2 associated binding protein 1 [Source:NCBI gene;Acc:101173122])

HSP 1 Score: 46.595 bits (109), Expect = 8.861e-6
Identity = 30/104 (28.85%), Postives = 52/104 (50.00%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYL 458
            E++ EG+L KSPP    E +++      WK+R+F+L   +   +    +Y+K  H T  P   IDL  C  +   +   K +   +E  ++ F+    DR++YL
Sbjct:    5 EVVCEGWLRKSPP----EKKLRR---YAWKKRWFVLRSGRLTGDPDVLEYYKNDH-TKKPIRVIDLNLCEQVDAGLTFSKKD---LEHSFI-FDIKTIDRVFYL 96
[Close]
BLAST of GRB2 associated binding protein-1 vs. Ensembl Medaka
Match: gab1 (GRB2 associated binding protein 1 [Source:NCBI gene;Acc:101173122])

HSP 1 Score: 46.595 bits (109), Expect = 8.982e-6
Identity = 30/104 (28.85%), Postives = 52/104 (50.00%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYL 458
            E++ EG+L KSPP    E +++      WK+R+F+L   +   +    +Y+K  H T  P   IDL  C  +   +   K +   +E  ++ F+    DR++YL
Sbjct:    5 EVVCEGWLRKSPP----EKKLRR---YAWKKRWFVLRSGRLTGDPDVLEYYKNDH-TKKPIRVIDLNLCEQVDAGLTFSKKD---LEHSFI-FDIKTIDRVFYL 96
[Close]
BLAST of GRB2 associated binding protein-1 vs. Ensembl Medaka
Match: gab1 (GRB2 associated binding protein 1 [Source:NCBI gene;Acc:101173122])

HSP 1 Score: 46.595 bits (109), Expect = 9.089e-6
Identity = 30/104 (28.85%), Postives = 52/104 (50.00%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYL 458
            E++ EG+L KSPP    E +++      WK+R+F+L   +   +    +Y+K  H T  P   IDL  C  +   +   K +   +E  ++ F+    DR++YL
Sbjct:    5 EVVCEGWLRKSPP----EKKLRR---YAWKKRWFVLRSGRLTGDPDVLEYYKNDH-TKKPIRVIDLNLCEQVDAGLTFSKKD---LEHSFI-FDIKTIDRVFYL 96
[Close]
BLAST of GRB2 associated binding protein-1 vs. Ensembl Medaka
Match: gab1 (GRB2 associated binding protein 1 [Source:NCBI gene;Acc:101173122])

HSP 1 Score: 46.2098 bits (108), Expect = 9.907e-6
Identity = 30/104 (28.85%), Postives = 52/104 (50.00%), Query Frame = 3 
Query:  147 EIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYL 458
            E++ EG+L KSPP    E +++      WK+R+F+L   +   +    +Y+K  H T  P   IDL  C  +   +   K +   +E  ++ F+    DR++YL
Sbjct:    5 EVVCEGWLRKSPP----EKKLRR---YAWKKRWFVLRSGRLTGDPDVLEYYKNDH-TKKPIRVIDLNLCEQVDAGLTFSKKD---LEHSFI-FDIKTIDRVFYL 96
[Close]
BLAST of GRB2 associated binding protein-1 vs. Planmine SMEST
Match: SMESG000035904.1 (SMESG000035904.1)

HSP 1 Score: 345.125 bits (884), Expect = 4.713e-123
Identity = 165/166 (99.40%), Postives = 166/166 (100.00%), Query Frame = 3 
Query:   45 MTEINIKGEQYVRKNSQKIKPQSKICYPLNTNHYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIVNALNMYKIK 542
            MTEINIKGEQYVRKNSQKIKPQSKICYPLNT+HYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIVNALNMYKIK
Sbjct:    1 MTEINIKGEQYVRKNSQKIKPQSKICYPLNTDHYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIVNALNMYKIK 166
[Close]
BLAST of GRB2 associated binding protein-1 vs. Planmine SMEST
Match: SMESG000074673.1 (SMESG000074673.1)

HSP 1 Score: 85.5001 bits (210), Expect = 4.836e-21
Identity = 52/128 (40.62%), Postives = 73/128 (57.03%), Query Frame = 3 
Query:  120 CYPLNTNHYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDLMQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWL 503
             YPL+   YEI K+GYL+KSPPL N        F  K+++RYFI++      ++I+FDYF +H     P G+IDL Q T I   V IE  N + IET+    NGS   R YYLT  +   +  +++W+
Sbjct:   19 IYPLDPADYEIHKQGYLIKSPPLKNGRRSNYFVFQSKYRKRYFIIH-TNNTNSKIYFDYFCKHEDLKYPKGSIDLNQITKISYPVHIEGKNRLLIETE----NGS-NRREYYLTSVNN-DEDEMQSWI 139
[Close]
BLAST of GRB2 associated binding protein-1 vs. Planmine SMEST
Match: SMESG000042332.1 (SMESG000042332.1)

HSP 1 Score: 51.6026 bits (122), Expect = 1.024e-7
Identity = 40/148 (27.03%), Postives = 72/148 (48.65%), Query Frame = 3 
Query:  138 NHYEIIKEGYLLKSPPLNN--------------DEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPT-GTIDLMQCTNIKMNV--KIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIVNALNM 530
            N+ +II EG L KSPPL +              D  +  + F K+W++RYF+L++  +  +++   YFK   L    + G+I+L    ++  +V  K+ K+N  +I+T     N    +R YYL+         ++ W+  +V  L +
Sbjct:    9 NNIQIIYEGILKKSPPLKSKSLFSMIAKFSCATDNEKTSIIFQKRWRKRYFVLFKNIDKPHDVHLLYFKSKPLPDSKSLGSINLENFRSLAFDVGKKLNKTNVFSIQTTDDKGN----NRDYYLS---ANSFEIMKTWVDKLVACLGL 149
[Close]
BLAST of GRB2 associated binding protein-1 vs. Planmine SMEST
Match: SMESG000042332.1 (SMESG000042332.1)

HSP 1 Score: 50.8322 bits (120), Expect = 2.008e-7
Identity = 38/134 (28.36%), Postives = 68/134 (50.75%), Query Frame = 3 
Query:  138 NHYEIIKEGYLLKSPPLNNDEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPT-GTIDLMQCTNIKMNV--KIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLEAWLTAIVNALNM 530
            N+ +II EG L KSPPL      +     K+W++RYF+L++  +  +++   YFK   L    + G+I+L    ++  +V  K+ K+N  +I+T     N    +R YYL+         ++ W+  +V  L +
Sbjct:    9 NNIQIIYEGILKKSPPLK--SKSLFSMIAKRWRKRYFVLFKNIDKPHDVHLLYFKSKPLPDSKSLGSINLENFRSLAFDVGKKLNKTNVFSIQTTDDKGN----NRDYYLS---ANSFEIMKTWVDKLVACLGL 133
The following BLAST results are available for this feature:
BLAST of GRB2 associated binding protein-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 3
Match NameE-valueIdentityDescription
I1ZIF95.902e-1738.89GRB2 associated binding protein-1 OS=Schmidtea med... [more]
A0A4E0RYK42.606e-630.00PH domain-containing protein OS=Fasciola hepatica ... [more]
A0A5K4F2S93.923e-635.00Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of GRB2 associated binding protein-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
gab18.861e-628.85GRB2 associated binding protein 1 [Source:NCBI gen... [more]
gab18.982e-628.85GRB2 associated binding protein 1 [Source:NCBI gen... [more]
gab19.089e-628.85GRB2 associated binding protein 1 [Source:NCBI gen... [more]
gab19.907e-628.85GRB2 associated binding protein 1 [Source:NCBI gen... [more]
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BLAST of GRB2 associated binding protein-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000035904.14.713e-12399.40SMESG000035904.1[more]
SMESG000074673.14.836e-2140.63SMESG000074673.1[more]
SMESG000042332.11.024e-727.03SMESG000042332.1[more]
SMESG000042332.12.008e-728.36SMESG000042332.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30022438 ID=SMED30022438|Name=GRB2 associated binding protein-1|organism=Schmidtea mediterranea sexual|type=transcript|length=621bp
TATATCTTTATGACATCAACATGAATTTATCATTACATTGTTAAATGACG
GAAATCAATATTAAAGGTGAGCAGTACGTCAGGAAAAATTCTCAGAAAAT
TAAACCTCAATCAAAGATTTGTTATCCATTAAACACGAATCATTACGAAA
TCATCAAAGAAGGCTATTTGCTGAAATCGCCGCCACTGAACAATGATGAA
GCAGAAATAAAAATGGGATTTTTAAAGAAATGGAAAAGGCGATATTTTAT
ATTGTATCGAGCAAAGGAATATGAGAATGAAATATTTTTCGACTATTTCA
AAAGGCATCATTTGACTCATATTCCAACTGGGACAATTGACCTAATGCAA
TGTACAAATATAAAGATGAATGTGAAAATCGAGAAAAGTAACGCCATGGC
AATTGAAACAAAATACGTCAATTTCAATGGATCATTAGCTGATCGGATTT
ATTATTTGACACCGACGGATCAGTGTCATCAGAGAACTTTAGAAGCATGG
CTTACTGCTATCGTAAATGCTTTGAATATGTACAAGATTAAATAATAATA
GTTTTTTTCATTTTGAAGCGAAAATTGTTATTTTATAATTTAGAGAGTTT
ATAATTTGCTTAGATTTTTTC
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protein sequence of SMED30022438-orf-1

>SMED30022438-orf-1 ID=SMED30022438-orf-1|Name=SMED30022438-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=167bp
MTEINIKGEQYVRKNSQKIKPQSKICYPLNTNHYEIIKEGYLLKSPPLNN
DEAEIKMGFLKKWKRRYFILYRAKEYENEIFFDYFKRHHLTHIPTGTIDL
MQCTNIKMNVKIEKSNAMAIETKYVNFNGSLADRIYYLTPTDQCHQRTLE
AWLTAIVNALNMYKIK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001849PH_domain
IPR011993PH-like_dom_sf
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 36..163
e-value: 1.7E-4
score: 31.0
IPR001849Pleckstrin homology domainPFAMPF00169PHcoord: 37..160
e-value: 9.3E-7
score: 29.3
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 35..161
score: 9.76
IPR011993PH-like domain superfamilyGENE3DG3DSA:2.30.29.30coord: 28..165
e-value: 3.2E-15
score: 57.7
NoneNo IPR availablePANTHERPTHR45960FAMILY NOT NAMEDcoord: 35..138
NoneNo IPR availableSUPERFAMILYSSF50729PH domain-likecoord: 35..162