Tctex1 domain containing 4

Overview


Name	Tctex1 domain containing 4
Smed ID	SMED30022401
Length (bp)	687

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Tctex1 domain containing 4 (SMED30022401) t-SNE clustered cells

Violin plots show distribution of expression levels for Tctex1 domain containing 4 (SMED30022401) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Tctex1 domain containing 4 (SMED30022401) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Tctex1 domain containing 4 (SMED30022401) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022401

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
head region	SMED30022401	SmedASXL_007731	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30022401	dd_Smed_v6_12765_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
head region	SMED30022401	OX_Smed_1.0.08037	ox_Smed_v2	PMID:24238224 Kao et al., 2013
epidermis	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal region of the epidermis	SMED30022401	dd_Smed_v4_12765_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Match: TCTEX1D1 (Tctex1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26882])

HSP 1 Score: 72.7886 bits (177), Expect = 2.227e-15
Identity = 46/132 (34.85%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  +Q ENTY++   K    +F       I+KD++ S L   +YEP     +T+ ++ +IK ++K+L   RYK I  + IGQ       +  SI+I S+ L  P S D+F  + + NSSLFA+A ++ +Y E
Sbjct:   59 RLTVQMENTYQLGPPK----HFPVVTVNHILKDVVTSYLQVEEYEPELCRQMTKTISEVIKAQVKDLMIPRYKLIVIVHIGQL------NRQSILIGSRCLWDPKS-DTFSSYVFRNSSLFALANVYAVYLE 179

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Match: TCTEX1D4 (Tctex1 domain containing 4 [Source:HGNC Symbol;Acc:HGNC:32315])

HSP 1 Score: 56.225 bits (134), Expect = 4.466e-9
Identity = 27/84 (32.14%), Postives = 43/84 (51.19%), Query Frame = 1

Query:  409 AAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            AA L + +   +  RL+EL   RYK +C + +G +      +   + + S+ L    + D      Y N+SLFAVA +HG+Y E
Sbjct:  145 AARLVRELCEQVHVRLRELSPPRYKLVCSVVLGPR------AGQGVHVVSRALWD-VARDGLASVSYTNTSLFAVATVHGLYCE 221

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Match: TCTEX1D2 (Tctex1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28482])

HSP 1 Score: 51.6026 bits (122), Expect = 6.658e-8
Identity = 30/109 (27.52%), Postives = 57/109 (52.29%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIY 654
            F+P+  +  +  +L   L   +Y P     LT++++  IK++LKE+  +RYK + Q+ IG+++ G G     + +AS+      + D++    + N SLF V    G +
Sbjct:   39 FRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQR-GEG-----VFMASRCFWDADT-DNYTHDVFMNDSLFCVVAAFGCF 140

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Match: TCTEX1D2 (Tctex1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28482])

HSP 1 Score: 46.9802 bits (110), Expect = 2.383e-6
Identity = 28/90 (31.11%), Postives = 48/90 (53.33%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGN--SNHSIIIASQMLSQPTSGDS 591
            F+P+  +  +  +L   L   +Y P     LT++++  IK++LKE+  +RYK + Q+ IG+++ G G       +I A   L  P S DS
Sbjct:   39 FRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQR-GEGVLLECSGMISAHCNLCLPGSSDS 127

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Match: AC069257.4 (novel protein)

HSP 1 Score: 45.8246 bits (107), Expect = 4.478e-6
Identity = 22/67 (32.84%), Postives = 39/67 (58.21%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNG 528
            F+P+  +  +  +L   L   +Y P     LT++++  IK++LKE+  +RYK + Q+ IG+ Q G G
Sbjct:   39 FRPSVVKDCIHAVLKEELANAEYSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGE-QRGEG 104

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Zebrafish
Match: tctex1d1 (Tctex1 domain containing 1 [Source:NCBI gene;Acc:447884])

HSP 1 Score: 65.855 bits (159), Expect = 4.827e-13
Identity = 43/133 (32.33%), Postives = 73/133 (54.89%), Query Frame = 1

Query:  262 RRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +RP +Q ENTY+I   ++    F     + ++KD+L S L   +YE      +T+ +T ++K R+K+L   RYK I  + IGQ +      + +I + S+ L    + D+F    ++N+SLFA A + G+Y E
Sbjct:   52 QRPTVQMENTYRITPSRR----FPVLTVKDLLKDVLTSYLQEEKYETELCRQMTKTITEVVKARVKDLMIPRYKIIVVISIGQIK------DQNIRMGSRCLWDD-NHDNFSSHIFKNNSLFAAATVFGVYFE 173

[Close]

Query:  262 RRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +RP +Q ENTY+I   ++    F     + ++KD+L S L   +YE      +T+ +T ++K R+K+L   RYK I  + IGQ +      + +I + S+ L    + D+F    ++N+SLFA A + G+Y E
Sbjct:   52 QRPTVQMENTYRITPSRR----FPVLTVKDLLKDVLTSYLQEEKYETELCRQMTKTITEVVKARVKDLMIPRYKIIVVISIGQIK------DQNIRMGSRCLWDD-NHDNFSSHIFKNNSLFAAATVFGVYFE 173

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Zebrafish
Match: tctex1d2 (Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-081104-219])

HSP 1 Score: 56.9954 bits (136), Expect = 6.055e-10
Identity = 38/123 (30.89%), Postives = 67/123 (54.47%), Query Frame = 1

Query:  286 NTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIY 654
            NTY I  + K    FK   A+  + +IL   L   QY+P     L++++ + IK++LK++  +RYK+I Q+ IG+++ G G     + +A++      + D++ +  Y N SLF VA    +Y
Sbjct:   35 NTYLIRPNYKDK--FKAGVAKECIGEILREQLYGVQYDPEEVPTLSRSLADSIKHKLKDMAFDRYKFIVQVVIGEQR-GEG-----VKMAARCFWDADT-DNYAQEIYMNDSLFCVAAAFAVY 148

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Zebrafish
Match: tctex1d2 (Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-081104-219])

HSP 1 Score: 46.9802 bits (110), Expect = 2.457e-6
Identity = 28/81 (34.57%), Postives = 48/81 (59.26%), Query Frame = 1

Query:  286 NTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNG 528
            NTY I  + K    FK   A+  + +IL   L   QY+P     L++++ + IK++LK++  +RYK+I Q+ IG+++ G G
Sbjct:   35 NTYLIRPNYKDK--FKAGVAKECIGEILREQLYGVQYDPEEVPTLSRSLADSIKHKLKDMAFDRYKFIVQVVIGEQR-GEG 112

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
Match: coq10b (coenzyme Q10B [Source:Xenbase;Acc:XB-GENE-5784252])

HSP 1 Score: 73.9442 bits (180), Expect = 6.410e-16
Identity = 45/133 (33.83%), Postives = 75/133 (56.39%), Query Frame = 1

Query:  262 RRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +RP I  ENTY+    K+    F       I+KD+L S L   +YE      +T+ ++ +IK R+K+L   RYK I  ++IGQ       ++ S+ + S+ +  P + D+F  + ++NSSLFA+A ++G+Y E
Sbjct:   56 QRPAILMENTYQTGPTKR----FPVASVNNILKDVLTSYLQEEKYEAELCRQMTKTISEVIKARVKDLMIPRYKIIVLIYIGQL------NDQSMRVGSRCIWDP-ANDTFSSYSFKNSSLFALANVYGVYYE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
Match: ENSXETT00000044463.1 (tctex1 domain-containing protein 1-like [Source:NCBI gene;Acc:100498184])

HSP 1 Score: 57.7658 bits (138), Expect = 1.061e-9
Identity = 31/103 (30.10%), Postives = 53/103 (51.46%), Query Frame = 1

Query:  352 IMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            ++++ L + L    Y+P + A LT+++   IK  ++ +   RYK IC + IG K          I++ SQ L    S D+     Y+N +LF V L++ +Y E
Sbjct:  127 LIEEFLATKLKNESYDPSTCAALTKDLCEDIKKIVRRVTPPRYKLICSMAIGSK------DREDIMVTSQCLWDSYS-DNVTSCSYQNRTLFCVVLVYAVYFE 222

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
Match: txnrd2 (thioredoxin reductase 2 [Source:Xenbase;Acc:XB-GENE-5767949])

HSP 1 Score: 57.3806 bits (137), Expect = 1.222e-9
Identity = 34/106 (32.08%), Postives = 53/106 (50.00%), Query Frame = 1

Query:  355 MKDILHS----NLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            MK +L S     L    Y P SA  L + ++  +K R+K +   RYK +C + +G++          I + S+ L   +  DS+V   YENSSLF V  ++ +Y E
Sbjct:   99 MKQVLESYLPERLGTITYNPASAPSLVKEVSEEVKGRVKRVLPTRYKALCVVTLGER------GQEDIAVVSRCLWD-SHSDSYVAHVYENSSLFCVVAVYAVYCE 197

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
Match: ENSXETT00000022071.1 (lysophosphatidic acid receptor 6-like [Source:Xenbase;Acc:XB-GENE-5721642])

HSP 1 Score: 51.2174 bits (121), Expect = 6.964e-8
Identity = 35/124 (28.23%), Postives = 62/124 (50.00%), Query Frame = 1

Query:  283 ENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIY 654
            ENTY I  + +    FK    +  ++ +L   L   QY P     LT+ ++  IK+RLK++  +RYK + Q+ IG+++ G G     + +A++      + D++ E  + N  LF V    G +
Sbjct:    8 ENTYSIRPNFQHK--FKSAPVKDCIRSVLKEELSDKQYVPEEVPQLTRFLSETIKDRLKDMGFDRYKMVVQVVIGEQR-GEG-----VKMAARCFWDADT-DNYAEDVFMNEYLFCVVAAFGCF 122

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
Match: Tctex1d1 (Tctex1 domain containing 1 [Source:MGI Symbol;Acc:MGI:1914594])

HSP 1 Score: 69.707 bits (169), Expect = 5.820e-15
Identity = 41/126 (32.54%), Postives = 70/126 (55.56%), Query Frame = 1

Query:  283 ENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:    2 ENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 116

[Close]

Query:  283 ENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:    2 ENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 116

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
Match: Tctex1d1 (Tctex1 domain containing 1 [Source:MGI Symbol;Acc:MGI:1914594])

HSP 1 Score: 71.2478 bits (173), Expect = 5.914e-15
Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  ++ ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:   57 RLTVRMENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
Match: Tctex1d1 (Tctex1 domain containing 1 [Source:MGI Symbol;Acc:MGI:1914594])

HSP 1 Score: 71.2478 bits (173), Expect = 6.115e-15
Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  ++ ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:   53 RLTVRMENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 173

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
Match: Tctex1d1 (Tctex1 domain containing 1 [Source:MGI Symbol;Acc:MGI:1914594])

HSP 1 Score: 71.2478 bits (173), Expect = 6.115e-15
Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  ++ ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:   53 RLTVRMENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 173

[Close]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Match: sp|A2VDD2|TC1DB_XENLA (Tctex1 domain-containing protein 1-B (Fragment) OS=Xenopus laevis OX=8355 GN=tctex1d1-b PE=2 SV=1)

HSP 1 Score: 73.559 bits (179), Expect = 6.386e-15
Identity = 44/133 (33.08%), Postives = 75/133 (56.39%), Query Frame = 1

Query:  262 RRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +RP I  ENTY++   K+    F       I+KD+L S L   +YE      +T+ ++ +IK R+K+L   RYK I  ++IGQ       ++  + + S+ +  P + D+F  + ++NSSLFA+A ++G+Y E
Sbjct:   55 QRPAILVENTYQMGPTKR----FPVASVNNILKDVLTSYLQEEKYEAELCRQMTKTISEVIKARVKDLMIPRYKIIVLIYIGQL------NDQGMRVGSRCIWDP-ANDTFSSYSFKNSSLFALANVYGVYYE 176

[Close]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Match: sp|Q3B8D7|TC1DA_XENLA (Tctex1 domain-containing protein 1-A OS=Xenopus laevis OX=8355 GN=tctex1d1-a PE=2 SV=1)

HSP 1 Score: 73.1738 bits (178), Expect = 7.154e-15
Identity = 45/131 (34.35%), Postives = 74/131 (56.49%), Query Frame = 1

Query:  268 PIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            P I  ENTY+I   K+    F       I+KD+L S L   +YE      +T+ ++ +IK R+K+L   RYK I  ++IGQ       ++ S+ + S+ +  P + D+F  + ++NSSLFA+A ++G+Y E
Sbjct:   58 PAILMENTYQIGPAKR----FPVASVNNILKDVLTSYLQEEKYEAELCRQMTKTISEVIKARVKDLMIPRYKIIVLIYIGQL------NDQSMRVGSRCIWDP-ANDTFSSYSFKNSSLFALANVYGVYYE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Match: sp|Q8N7M0|TC1D1_HUMAN (Tctex1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TCTEX1D1 PE=1 SV=2)

HSP 1 Score: 72.7886 bits (177), Expect = 1.069e-14
Identity = 46/132 (34.85%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  +Q ENTY++   K    +F       I+KD++ S L   +YEP     +T+ ++ +IK ++K+L   RYK I  + IGQ       +  SI+I S+ L  P S D+F  + + NSSLFA+A ++ +Y E
Sbjct:   59 RLTVQMENTYQLGPPK----HFPVVTVNHILKDVVTSYLQVEEYEPELCRQMTKTISEVIKAQVKDLMIPRYKLIVIVHIGQL------NRQSILIGSRCLWDPKS-DTFSSYVFRNSSLFALANVYAVYLE 179

[Close]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Match: sp|Q9D5I4|TC1D1_MOUSE (Tctex1 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Tctex1d1 PE=2 SV=1)

HSP 1 Score: 71.2478 bits (173), Expect = 4.278e-14
Identity = 42/132 (31.82%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R  ++ ENTY++   K     F       I++D+L + L   QY+P     +T+ ++ +IK ++KEL   RYK I  ++IGQ+       + SI+I S+ L  P S D+   + ++NS+ FA+A ++ +Y E
Sbjct:   53 RLTVRMENTYQLGPTKP----FPVATVNHILEDVLTTYLQEAQYDPEFCRQMTKTISEVIKTQVKELVIPRYKLIVIVYIGQR------DDQSIVIGSRCLWNPKS-DTVSSYTFKNSTFFALANVYAVYFE 173

[Close]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Match: sp|Q66IC8|TC1D1_DANRE (Tctex1 domain-containing protein 1 OS=Danio rerio OX=7955 GN=tctex1d1 PE=2 SV=1)

HSP 1 Score: 65.855 bits (159), Expect = 3.644e-12
Identity = 43/133 (32.33%), Postives = 73/133 (54.89%), Query Frame = 1

Query:  262 RRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +RP +Q ENTY+I   ++    F     + ++KD+L S L   +YE      +T+ +T ++K R+K+L   RYK I  + IGQ +      + +I + S+ L    + D+F    ++N+SLFA A + G+Y E
Sbjct:   52 QRPTVQMENTYRITPSRR----FPVLTVKDLLKDVLTSYLQEEKYETELCRQMTKTITEVVKARVKDLMIPRYKIIVVISIGQIK------DQNIRMGSRCLWDD-NHDNFSSHIFKNNSLFAAATVFGVYFE 173

[Close]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Match: A0A0Q3RGZ2 (Tctex1 domain-containing protein 4 OS=Amazona aestiva OX=12930 GN=AAES_45136 PE=4 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 3.214e-22
Identity = 62/185 (33.51%), Postives = 97/185 (52.43%), Query Frame = 1

Query:  136 RKQSVISTATNATDDLLKRNSRRYGGSRASI--------FSGSGLAMFPGRRPIIQ--YENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R+ S++ST   A            GG R SI         S SGL +F   +PI++   ENTY+I  D+     F   + + +++  L   L+   Y P  +A+L QN+  ++++R KE+   RYK +C + +GQ+      +  S+++ASQ L  P S DSF    + N+SLFAVA +HG+Y E
Sbjct:   51 RRSSILSTLPAALASRRSSLGAAPGGRRPSIGPWMLHSRVSFSGLPLF---QPILKTRLENTYRIGPDEGCK--FNAGRVQRVLEGALTGALETMVYTPQGSALLAQNLAEMLQSRAKEVVPPRYKXVCHVLLGQQ------AQQSLLVASQALWDPKS-DSFASATFSNASLFAVATVHGVYFE 223

[Close]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Match: A0A2I0LPA2 (Tctex1 domain containing 4 OS=Columba livia OX=8932 GN=TCTEX1D4 PE=4 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 8.251e-21
Identity = 54/161 (33.54%), Postives = 89/161 (55.28%), Query Frame = 1

Query:  208 GGSRASI--------FSGSGLAMFPGRRPIIQ--YENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            GG R S+         S SGL +F   +PI++   ENTY++  D+     F   + + ++  +L S L    Y P  +A+L Q++  +++ R+KE+   RYK +CQ+ +GQ+         S+++AS+ L  P S D+F    + N+SLFAVA +HG+Y E
Sbjct:   74 GGRRPSVGPWMFHSRVSFSGLPLF---QPILKTRLENTYRMRPDEGCK--FDAGRVQQVLDTVLASTLGTTVYSPQGSALLAQSLAELLRGRVKEVVPPRYKLVCQVLLGQR------GQQSLLVASRALWDPES-DNFASTTFSNASLFAVATVHGVYLE 222

[Close]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Match: A0A2D4JNU5 (Uncharacterized protein OS=Micrurus lemniscatus lemniscatus OX=129467 PE=4 SV=1)

HSP 1 Score: 94.7449 bits (234), Expect = 4.473e-20
Identity = 63/189 (33.33%), Postives = 98/189 (51.85%), Query Frame = 1

Query:  124 IPSIRKQSVISTATNATDDLLKRNSRRYGGSRASI--------FSGSGLAMFPGRRPI--IQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
             P  R+ S++S          +RNS   GG R SI         S SGL +F    PI  + YENTYK   DK  +  F  ++ + +++ +L S     +Y P ++  L QN+++++++R+K+L   RYK +C +F+GQ       +N  + IAS+ L      DSF    + NSSLFAV  +H +Y E
Sbjct:   43 FPPSRRSSIMSILNAPFSS--RRNSLAAGGRRLSIGPWMHCGRVSFSGLPLF---EPIQEVHYENTYKTQPDK--DCRFNSSRTQQVLESVLASFFSDIKYNPANSGQLVQNLSDLVRSRVKDLTPPRYKLVCNVFLGQL------ANQGLHIASRSLWD-VENDSFASATFTNSSLFAVITVHALYYE 217

[Close]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Match: W4XM66 (Uncharacterized protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1)

HSP 1 Score: 90.1225 bits (222), Expect = 4.499e-19
Identity = 49/148 (33.11%), Postives = 87/148 (58.78%), Query Frame = 1

Query:  217 RASIFSGSGLAMFPGRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R+++ +  G +  PGR P +++E TYK++ D+K    F    A+ I++DIL + L+   Y+P  + VL + + ++IK+R+KEL   RYK I  + I       G++ H+ + A+         DS+ ++ Y+N SL+A  +++GIYQE
Sbjct:   15 RSAMDARGGGSTAPGR-PAVRFECTYKMEPDRK----FMVGAAKQIIEDILTAQLESQSYDPQKSQVLCRELADVIKHRVKELLIPRYKIIALVTI-------GSAEHADVCAASQCVWNDKFDSYAQYTYKNGSLYATGIVYGIYQE 150

[Close]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Match: A0A493TD63 (Tctex1 domain containing 4 OS=Anas platyrhynchos platyrhynchos OX=8840 GN=TCTEX1D4 PE=4 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 1.210e-18
Identity = 59/185 (31.89%), Postives = 91/185 (49.19%), Query Frame = 1

Query:  136 RKQSVISTATNATDDLLKRNSRRYGGSRASI--------FSGSGLAMFPGRRPI--IQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            R+ SV+ST                GG R SI         S SGL +F   +PI  I+ ENTY++  D+     F   + + +++ +L   L    Y P   A L  ++  +++ R KE+   RYK +C + +GQ      +   S+++AS+ L  P S DSF    + N+SLFAVA +HG+Y E
Sbjct:  127 RRSSVLSTLPAPLASRRSSLGAAPGGKRPSIGPWMLHSRVSFSGLPLF---QPIPEIRLENTYRMGPDEGCG--FNAGQVQRVLERVLAGVLGGTSYSPQGGASLVHSLAELLRGRAKEVVPPRYKLVCHVLLGQ------HGQQSLLVASRALWDPQS-DSFASATFSNASLFAVATVHGVYFE 299

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Cavefish
Match: tctex1d1 (Tctex1 domain containing 1 [Source:NCBI gene;Acc:103044040])

HSP 1 Score: 70.0922 bits (170), Expect = 1.426e-14
Identity = 45/132 (34.09%), Postives = 73/132 (55.30%), Query Frame = 1

Query:  265 RPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            RP +Q ENTY++   K+    F     + I+KD+L S L   +YE      +T+ ++ ++K R+K++   RYK I  + IGQ     G + H   + S+ L   TS D+F    ++NSSLFA+A ++ +Y E
Sbjct:   57 RPAVQMENTYQLGPKKR----FPVQTVKEILKDVLSSYLLEVKYEAELCRQMTKTISEVVKARVKDMMIPRYKIIVVISIGQL---TGQNMH---VGSRCLWDATS-DTFCSNSFKNSSLFAIANVYAVYFE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Cavefish
Match: tctex1d2 (Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GENE-081104-219])

HSP 1 Score: 56.225 bits (134), Expect = 7.895e-10
Identity = 34/109 (31.19%), Postives = 57/109 (52.29%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIY 654
            F+P      +++++   L    Y+   +A   Q ++  I +RLKEL  +RYK + Q+ IG+++ G G     + +AS+      + DS  +  Y N SLF VA + GIY
Sbjct:   42 FRPAVVSSCIRELVREQLGGESYDSERSAETAQTLSKRITDRLKELGLDRYKLVVQVVIGEQR-GEG-----VQMASRCFWDADT-DSCAKDVYMNDSLFCVAAVFGIY 143

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Cavefish
Match: ENSAMXT00000038759.1 (tctex1 domain-containing protein 1-A-like [Source:NCBI gene;Acc:103036543])

HSP 1 Score: 55.8398 bits (133), Expect = 2.555e-9
Identity = 37/141 (26.24%), Postives = 68/141 (48.23%), Query Frame = 1

Query:  238 SGLAMFPGRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            S L ++PG+    +Y+           +  F   +   +MK I+ + L   QY    +AV  + +++ IK   K L   RYK I  + IGQ +      +  +  +S+ +  P + D+F E+ ++N  LFA+ ++  +YQE
Sbjct:   74 SSLTVYPGQSEWQEYQTA--------PHRRFPREQVRSVMKSIVEARLGEAQYTSRCSAV-ARKLSDSIKEAAKSLSYERYKLISYVAIGQLR------DSEVTCSSRGVWCP-AADTFTEYTFKNDHLFALCVLFAVYQE 198

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008035.1 (pep scaffold:Pmarinus_7.0:GL476353:419801:420827:1 gene:ENSPMAG00000007269.1 transcript:ENSPMAT00000008035.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 45.0542 bits (105), Expect = 9.436e-7
Identity = 30/112 (26.79%), Postives = 52/112 (46.43%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQ-YEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            F   + E ++++ L  +L   +  +  + A L   ++  IK R KE    RYK I  + +G  +         +++AS+ L  P + D+F    Y   + F VA I G+Y E
Sbjct:    1 FPVERLERLLEETLTRHLGEGEALDAAACARLAPLLSEEIKARAKEQTPTRYKLIVSVTLGSWE------REQVVVASRCLWDP-AADAFASHHYRRGARFCVATIFGVYYE 105

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Match: EDO45441 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTB6])

HSP 1 Score: 75.0998 bits (183), Expect = 6.075e-17
Identity = 46/134 (34.33%), Postives = 73/134 (54.48%), Query Frame = 1

Query:  259 GRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            G  P++  ENTY+    KK    F       IMK++L  NL    Y+P++   LT+ ++  +KNR+KEL   RYK IC + IGQ          ++ I S+ L    + D++  ++++N SLF VA ++G+Y E
Sbjct:   57 GMEPVM--ENTYQTTPTKK----FPEGNIRNIMKEVLIENLADVNYDPNTCRQLTKTISETLKNRVKELSVQRYKIICLVHIGQL------GKQAMRIGSRCLWD-ANFDTYTTYEFKNGSLFGVATVYGVYFE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Match: EDO33563 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRY5])

HSP 1 Score: 69.707 bits (169), Expect = 9.053e-16
Identity = 36/107 (33.64%), Postives = 58/107 (54.21%), Query Frame = 1

Query:  340 KAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            + E ++KDIL  +LD   YEP+   +    +TN +K R+K L   RYKY+C   +G+        N+  + A    +  T  DSF +++Y N SL+ + L++ IY E
Sbjct:    1 RIEPLIKDILEEHLDNQTYEPNFCRLAAIKITNQLKERMKRLRYPRYKYVCHAMLGE-------INNQDVRAVSRCAWDTCVDSFAQYEYRNCSLYGIGLVYAIYFE 100

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Match: EDO45313 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT02])

HSP 1 Score: 62.3882 bits (150), Expect = 7.447e-13
Identity = 40/126 (31.75%), Postives = 66/126 (52.38%), Query Frame = 1

Query:  283 ENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            +NTY+++   +    F   K + I+++    +L+ + YE      +T  ++ +IK R+K L   RYK IC ++IGQ        N  + I S+ L   T+ D+ VE  Y N +LFAVA + G + E
Sbjct:    1 KNTYRMEPSNR----FSHKKVKDIIEEAFQEHLNEHSYEAEFCKHMTTKLSELIKQRVKHLGFTRYKLICIVYIGQVM------NQGMRIGSRCLWN-TNFDNVVEGSYRNGNLFAVATVFGAFVE 115

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Match: EDO44337 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW25])

HSP 1 Score: 62.7734 bits (151), Expect = 1.034e-12
Identity = 38/134 (28.36%), Postives = 75/134 (55.97%), Query Frame = 1

Query:  259 GRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            G    ++YENTYK++ DK+    F   + + IM++ L  +L   +Y+      ++++++  I  R+K L   ++K +C + IG+       +N  I +AS+ L      D++V+  + ++ LFAVA+++ +YQE
Sbjct:   13 GHHQKVRYENTYKLEPDKR----FNVQEVKEIMEETLEESLKDEKYDAIKCRGMSRSLSQTICERVKLLGFKQFKIVCTVTIGEM------NNQGIRVASRFLWNEKH-DNWVDSVFRSNELFAVAVVYAVYQE 135

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Match: EDO46990 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNU7])

HSP 1 Score: 62.003 bits (149), Expect = 1.197e-12
Identity = 41/125 (32.80%), Postives = 64/125 (51.20%), Query Frame = 1

Query:  286 NTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            NTYK+  D K    F P K E + + +L   L    Y+P +       + + I +++K L  +RYK +C   IG+       ++ +I I S+      + D++ E  Y NS+LFAV  I+GIYQE
Sbjct:    2 NTYKLGPDNK----FSPAKVEEVAQSVLQKVLAESVYDPKTCRTQAMEIGDEILSQVKALGFDRYKIVCLTNIGKV------NDQTIRIGSR-CCWDQNLDNYAEAVYTNSTLFAVTAIYGIYQE 115

[Close]

BLAST of Tctex1 domain containing 4 vs. Ensembl Medaka
Match: tctex1d2 (Tctex1 domain containing 2 [Source:NCBI gene;Acc:101160473])

HSP 1 Score: 51.2174 bits (121), Expect = 5.302e-8
Identity = 30/109 (27.52%), Postives = 56/109 (51.38%), Query Frame = 1

Query:  328 FKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIY 654
            FKP   +  + +I+   L   +YEP        ++ + I++++K L  ++YK I Q+ IG+++ G G     + + S+      + D++ E  + N SLF VA + G Y
Sbjct:   40 FKPAIVKEFVHEIVRERLSGVKYEPEKIPETCSSLADCIRDKVKSLGIDKYKIIVQVMIGEQR-GQG-----VKMCSRFFWDADT-DNYAEDVFMNDSLFCVAAVFGCY 141

[Close]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Match: SMESG000018052.1 (SMESG000018052.1)

HSP 1 Score: 95.1301 bits (235), Expect = 2.868e-24
Identity = 61/175 (34.86%), Postives = 93/175 (53.14%), Query Frame = 1

Query:  142 QSVISTATNATDDLLKRNSRRYGGSRASIFSGSGLAMFPGRR--PIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            Q+ ++ + +    LLK       G R SI+          R+  P IQYENTY++D D K    F   K + I+ D L   L  Y+Y+P+SA  +T+ +T  IK ++KEL S RYK++  + +G K  G      +I   S+ L    SGD+F E  Y N +++A+A ++GIY E
Sbjct:   11 QTGVAASDSRRASLLKWRRSTLVGPRKSIYMNQPNLWNLDRKIMPQIQYENTYRMDADPKET--FLSHKVKSILTDELKRVLHDYKYDPNSANEMTRILTEKIKFKMKELPSVRYKFVVIVVLGNKNSG------AICYGSRALWNDKSGDTFSEVSYTNDNIYAIATVYGIYYE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Match: SMESG000017994.1 (SMESG000017994.1)

HSP 1 Score: 93.5893 bits (231), Expect = 1.034e-23
Identity = 60/175 (34.29%), Postives = 94/175 (53.71%), Query Frame = 1

Query:  142 QSVISTATNATDDLLKRNSRRYGGSRASIFSGSGLAMFPGRR--PIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            Q+ ++ + +    LLK       G R SI+          R+  P IQYENTY++D + K    F   KA+ I+ D L   L  Y+Y+P++A  +T+ +T  IK ++KEL S RYK++  + +G K  G      +I   S+ L    SGD+F E  Y N +++A+A ++GIY E
Sbjct:   11 QTGVAASDSRRASLLKWRRSTLVGPRKSIYMNQPNLWNLDRKIMPQIQYENTYRMDANPKET--FLSHKAKSILTDELKRVLHNYKYDPNNANEMTRILTEKIKFKMKELPSVRYKFVVIVVLGNKNSG------AICYGSRALWNDKSGDTFSEVSYTNDNIYAIATVYGIYYE 177

[Close]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Match: SMESG000040148.1 (SMESG000040148.1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.603e-23
Identity = 50/135 (37.04%), Postives = 78/135 (57.78%), Query Frame = 1

Query:  256 PGRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            P  RP ++ ENTY++  D+K    F   K E I KD++ S L   +YEP     +++ ++ +++NR+KEL   RYK +  + +G++       +H     S+ L  P S DSF  ++++N SLFAVA I GIYQE
Sbjct:   52 PASRPTVRVENTYQLGPDQK----FPVRKIETIAKDVIESYLAEERYEPQFCKAMSKTISEVVRNRIKELRIKRYKVVAIIQVGEQ------GDHGFTTTSRCLWDP-SIDSFACYEFKNGSLFAVATIFGIYQE 175

[Close]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Match: SMESG000040148.1 (SMESG000040148.1)

HSP 1 Score: 93.2041 bits (230), Expect = 2.378e-23
Identity = 50/135 (37.04%), Postives = 78/135 (57.78%), Query Frame = 1

Query:  256 PGRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            P  RP ++ ENTY++  D+K    F   K E I KD++ S L   +YEP     +++ ++ +++NR+KEL   RYK +  + +G++       +H     S+ L  P S DSF  ++++N SLFAVA I GIYQE
Sbjct:   64 PASRPTVRVENTYQLGPDQK----FPVRKIETIAKDVIESYLAEERYEPQFCKAMSKTISEVVRNRIKELRIKRYKVVAIIQVGEQ------GDHGFTTTSRCLWDP-SIDSFACYEFKNGSLFAVATIFGIYQE 187

[Close]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Match: SMESG000021852.1 (SMESG000021852.1)

HSP 1 Score: 68.9366 bits (167), Expect = 2.483e-14
Identity = 45/153 (29.41%), Postives = 78/153 (50.98%), Query Frame = 1

Query:  214 SRASIFSGSGLAMFPGRRPI----IQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLDRYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNSNHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE 660
            SR SI+S       PG++ +    IQYENTY+I  +       K  +   I++D+L   L   +Y+      L++ + + IK  +++L  NR+K +C + IG K      S  ++ IAS+ L    +GD   +  ++  S+FA+  + G+Y E
Sbjct:   43 SRGSIWSMQN----PGKKTLLSLPIQYENTYRIMPENHEKFTMKTIRQ--IIQDVLSDCLSGVKYDSKVVPELSKLIADRIKRLVRDLCYNRFKLVCIVLIGDK------SGANVCIASRCLWNSENGDDVAQASFDGGSIFAIGTVFGLYFE 183

The following BLAST results are available for this feature:

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
BLAST of Tctex1 domain containing 4 vs. Ensembl Celegans
BLAST of Tctex1 domain containing 4 vs. Ensembl Fly
BLAST of Tctex1 domain containing 4 vs. Ensembl Zebrafish
BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
BLAST of Tctex1 domain containing 4 vs. TrEMBL
BLAST of Tctex1 domain containing 4 vs. Ensembl Cavefish
BLAST of Tctex1 domain containing 4 vs. Ensembl Sea Lamprey
BLAST of Tctex1 domain containing 4 vs. Ensembl Yeast
BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
BLAST of Tctex1 domain containing 4 vs. Ensembl Medaka
BLAST of Tctex1 domain containing 4 vs. Planmine SMEST

BLAST of Tctex1 domain containing 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TCTEX1D1	2.227e-15	34.85	Tctex1 domain containing 1 [Source:HGNC Symbol;Acc...	[more]
TCTEX1D4	4.466e-9	32.14	Tctex1 domain containing 4 [Source:HGNC Symbol;Acc...	[more]
TCTEX1D2	6.658e-8	27.52	Tctex1 domain containing 2 [Source:HGNC Symbol;Acc...	[more]
TCTEX1D2	2.383e-6	31.11	Tctex1 domain containing 2 [Source:HGNC Symbol;Acc...	[more]
AC069257.4	4.478e-6	32.84	novel protein	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Tctex1 domain containing 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Tctex1 domain containing 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
tctex1d1	4.827e-13	32.33	Tctex1 domain containing 1 [Source:NCBI gene;Acc:4...	[more]
tctex1d1	4.827e-13	32.33	Tctex1 domain containing 1 [Source:NCBI gene;Acc:4...	[more]
tctex1d2	6.055e-10	30.89	Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GE...	[more]
tctex1d2	2.457e-6	34.57	Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GE...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
coq10b	6.410e-16	33.83	coenzyme Q10B [Source:Xenbase;Acc:XB-GENE-5784252]	[more]
ENSXETT00000044463.1	1.061e-9	30.10	tctex1 domain-containing protein 1-like [Source:NC...	[more]
txnrd2	1.222e-9	32.08	thioredoxin reductase 2 [Source:Xenbase;Acc:XB-GEN...	[more]
ENSXETT00000022071.1	6.964e-8	28.23	lysophosphatidic acid receptor 6-like [Source:Xenb...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tctex1d1	5.820e-15	32.54	Tctex1 domain containing 1 [Source:MGI Symbol;Acc:...	[more]
Tctex1d1	5.820e-15	32.54	Tctex1 domain containing 1 [Source:MGI Symbol;Acc:...	[more]
Tctex1d1	5.914e-15	31.82	Tctex1 domain containing 1 [Source:MGI Symbol;Acc:...	[more]
Tctex1d1	6.115e-15	31.82	Tctex1 domain containing 1 [Source:MGI Symbol;Acc:...	[more]
Tctex1d1	6.115e-15	31.82	Tctex1 domain containing 1 [Source:MGI Symbol;Acc:...	[more]

BLAST of Tctex1 domain containing 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|A2VDD2\|TC1DB_XENLA	6.386e-15	33.08	Tctex1 domain-containing protein 1-B (Fragment) OS...	[more]
sp\|Q3B8D7\|TC1DA_XENLA	7.154e-15	34.35	Tctex1 domain-containing protein 1-A OS=Xenopus la...	[more]
sp\|Q8N7M0\|TC1D1_HUMAN	1.069e-14	34.85	Tctex1 domain-containing protein 1 OS=Homo sapiens...	[more]
sp\|Q9D5I4\|TC1D1_MOUSE	4.278e-14	31.82	Tctex1 domain-containing protein 1 OS=Mus musculus...	[more]
sp\|Q66IC8\|TC1D1_DANRE	3.644e-12	32.33	Tctex1 domain-containing protein 1 OS=Danio rerio ...	[more]

BLAST of Tctex1 domain containing 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0Q3RGZ2	3.214e-22	33.51	Tctex1 domain-containing protein 4 OS=Amazona aest...	[more]
A0A2I0LPA2	8.251e-21	33.54	Tctex1 domain containing 4 OS=Columba livia OX=893...	[more]
A0A2D4JNU5	4.473e-20	33.33	Uncharacterized protein OS=Micrurus lemniscatus le...	[more]
W4XM66	4.499e-19	33.11	Uncharacterized protein OS=Strongylocentrotus purp...	[more]
A0A493TD63	1.210e-18	31.89	Tctex1 domain containing 4 OS=Anas platyrhynchos p...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
tctex1d1	1.426e-14	34.09	Tctex1 domain containing 1 [Source:NCBI gene;Acc:1...	[more]
tctex1d2	7.895e-10	31.19	Tctex1 domain containing 2 [Source:ZFIN;Acc:ZDB-GE...	[more]
ENSAMXT00000038759.1	2.555e-9	26.24	tctex1 domain-containing protein 1-A-like [Source:...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000008035.1	9.436e-7	26.79	pep scaffold:Pmarinus_7.0:GL476353:419801:420827:1...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Tctex1 domain containing 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO45441	6.075e-17	34.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33563	9.053e-16	33.64	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45313	7.447e-13	31.75	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44337	1.034e-12	28.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46990	1.197e-12	32.80	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Tctex1 domain containing 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
tctex1d2	5.302e-8	27.52	Tctex1 domain containing 2 [Source:NCBI gene;Acc:1...	[more]

BLAST of Tctex1 domain containing 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000018052.1	2.868e-24	34.86	SMESG000018052.1	[more]
SMESG000017994.1	1.034e-23	34.29	SMESG000017994.1	[more]
SMESG000040148.1	1.603e-23	37.04	SMESG000040148.1	[more]
SMESG000040148.1	2.378e-23	37.04	SMESG000040148.1	[more]
SMESG000021852.1	2.483e-14	29.41	SMESG000021852.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022401 ID=SMED30022401|Name=Tctex1 domain containing 4|organism=Schmidtea mediterranea sexual|type=transcript|length=687bp
CTAGACAGTGTTTAGAGACCGTTATTTAAAAACAATAGCTAAAAGTTGGT
TCCTTGATCTGACTACTTAAAAACTAGAATTCTGATGGCAAACGTCAGCA
GTAACTCAAATACTCAGCTCTTGATTCCATCAATAAGGAAACAGAGTGTT
ATTTCCACAGCAACTAATGCCACTGACGACTTATTGAAAAGAAATAGCCG
AAGATATGGAGGCAGTCGTGCTAGTATTTTTAGTGGATCAGGTCTGGCGA
TGTTTCCAGGCCGTCGTCCAATAATTCAATACGAAAACACCTACAAAATC
GATGTTGATAAAAAGAGCAATGGATATTTTAAACCGACAAAAGCAGAATT
CATCATGAAAGACATATTGCACAGTAATCTCGATCGATATCAGTATGAGC
CACACAGTGCTGCTGTTTTAACGCAAAACATGACAAATATTATTAAAAAC
CGATTAAAAGAATTGGACAGCAATCGCTACAAGTACATCTGTCAGTTGTT
TATCGGCCAGAAACAATGTGGAAATGGAAATTCTAACCATTCAATCATCA
TTGCAAGCCAAATGCTTTCACAGCCGACAAGTGGGGACAGCTTTGTAGAA
TTCAAATACGAAAACAGTTCATTGTTTGCAGTTGCTTTAATTCATGGAAT
TTACCAGGAATGAAAATATCAATAATAATAATAATAA

protein sequence of SMED30022401-orf-1

>SMED30022401-orf-1 ID=SMED30022401-orf-1|Name=SMED30022401-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=193bp
MANVSSNSNTQLLIPSIRKQSVISTATNATDDLLKRNSRRYGGSRASIFS
GSGLAMFPGRRPIIQYENTYKIDVDKKSNGYFKPTKAEFIMKDILHSNLD
RYQYEPHSAAVLTQNMTNIIKNRLKELDSNRYKYICQLFIGQKQCGNGNS
NHSIIIASQMLSQPTSGDSFVEFKYENSSLFAVALIHGIYQE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005930	axoneme
GO:0036126	sperm flagellum

Vocabulary: **molecular function**
Term	Definition
GO:0008157	protein phosphatase 1 binding
GO:0005515	protein binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000054	dorsal region of the epidermis
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR038586	Tctex-1-like_sf
IPR005334	Tctex-1-like

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR038586	Tctex-1-like superfamily	GENE3D	G3DSA:3.30.1140.40		coord: 86..190 e-value: 1.0E-11 score: 46.6
IPR005334	Dynein light chain Tctex-1 like	PFAM	PF03645	Tctex-1	coord: 88..190 e-value: 7.3E-17 score: 61.5
IPR005334	Dynein light chain Tctex-1 like	PANTHER	PTHR21255	T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN	coord: 58..192
None	No IPR available	PANTHER	PTHR21255:SF44	TCTEX1 DOMAIN-CONTAINING PROTEIN 1	coord: 58..192

Main menu

Tctex1 domain containing 4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

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