Glia maturation factor

Overview


Name	Glia maturation factor
Smed ID	SMED30022205
Length (bp)	834

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Glia maturation factor (SMED30022205) t-SNE clustered cells

Violin plots show distribution of expression levels for Glia maturation factor (SMED30022205) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Glia maturation factor (SMED30022205) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Glia maturation factor (SMED30022205) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022205

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
intestinal phagocyte	SMED30022205	h1SMcG0005341	Contig3584	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30022205	h1SMcG0005341	PL04020B1G08	smed_ncbi_20240424	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30022205	h1SMcG0011766	Contig3584	GPL15192	PMID:23079596 Forsthoefel et al., 2012
parenchymal cell	SMED30022205	h1SMcG0005341	dd_Smed_v4_2804_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Glia maturation factor vs. Ensembl Human
Match: GMFB (glia maturation factor beta [Source:HGNC Symbol;Acc:HGNC:4373])

HSP 1 Score: 150.214 bits (378), Expect = 4.481e-45
Identity = 66/129 (51.16%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Human
Match: GMFB (glia maturation factor beta [Source:HGNC Symbol;Acc:HGNC:4373])

HSP 1 Score: 145.976 bits (367), Expect = 3.435e-43
Identity = 66/130 (50.77%), Postives = 95/130 (73.08%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPR-FVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PR F+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:   17 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRTFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 146

[Close]

BLAST of Glia maturation factor vs. Ensembl Human
Match: GMFG (glia maturation factor gamma [Source:HGNC Symbol;Acc:HGNC:4374])

HSP 1 Score: 134.806 bits (338), Expect = 4.698e-39
Identity = 60/129 (46.51%), Postives = 88/129 (68.22%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V   L E L +F+F K   N+A+I+KV+K    + L+++ +++  +EL  ELP  +PRFVV SY +   DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+R  ++++  W
Sbjct:    5 LVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Human
Match: GMFG (glia maturation factor gamma [Source:HGNC Symbol;Acc:HGNC:4374])

HSP 1 Score: 122.479 bits (306), Expect = 2.552e-34
Identity = 56/115 (48.70%), Postives = 79/115 (68.70%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITK 454
            L++C V   L E L +F+F K   N+A+I+KV+K    + L+++ +++  +EL  ELP  +PRFVV SY +   DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK
Sbjct:    5 LVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTK 119

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BLAST of Glia maturation factor vs. Ensembl Celegans
Match: Y50D7A.10 (pep chromosome:WBcel235:III:315460:321721:1 gene:WBGene00021758.1 transcript:Y50D7A.10.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y50D7A.10)

HSP 1 Score: 114.775 bits (286), Expect = 1.065e-31
Identity = 57/128 (44.53%), Postives = 87/128 (67.97%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVE 493
            L IC++ + +KE L +F+F+K  T +ALI+K+++   EL+ +Q L D  ++E   ELPS +PRF++LS+  K  D RISYP  LI+  P G  PELQM+YAGS N +V+   ++K+ E+R+ +EI  E
Sbjct:    5 LTICSIPDGVKEDLKKFRFSKSTTMNALILKIDRESHELQSEQLLNDCSIEEFKEELPSQQPRFILLSWCKKHSDERISYPMLLIYYCPNGSSPELQMLYAGSRNFIVNECHVSKNTEIRDIDEIDDE 132

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BLAST of Glia maturation factor vs. Ensembl Fly
Match: GMF (gene:FBgn0028894 transcript:FBtr0080851)

HSP 1 Score: 115.161 bits (287), Expect = 1.035e-31
Identity = 54/127 (42.52%), Postives = 84/127 (66.14%), Query Frame = 2

Query:  116 ICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            IC++S  + E L +F+F+K K N+ALI+KV++    + LD+ ++D+ VDEL + LP H+PR+V+ +Y     D RISYP C IF TP   + ELQMMYA + + L     +T+ +E+R  +E++ EW
Sbjct:    6 ICDISNEVLEELKKFRFSKSKNNAALILKVDREKQTVVLDEFIDDISVDELQDTLPGHQPRYVIYTYKMVHDDQRISYPMCFIFYTPRDSQIELQMMYACTKSALQREVDLTRVYEIRELDELTEEW 132

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BLAST of Glia maturation factor vs. Ensembl Zebrafish
Match: gmfb (glia maturation factor, beta [Source:ZFIN;Acc:ZDB-GENE-040426-2114])

HSP 1 Score: 142.124 bits (357), Expect = 4.855e-42
Identity = 64/129 (49.61%), Postives = 92/129 (71.32%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V E L + L  F+F K   N+A+I+K++K    + L+++ ED+  ++L NELP  +PRFVV SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCEVDEDLVKKLRDFRFRKETNNAAIIMKIDKDKQLVILEEEHEDISPEDLKNELPERQPRFVVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTVELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Xenopus
Match: gmfb (glia maturation factor, beta [Source:NCBI gene;Acc:549756])

HSP 1 Score: 142.895 bits (359), Expect = 3.469e-42
Identity = 63/129 (48.84%), Postives = 92/129 (71.32%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V   L E L +F+F K   N+A+I+K++K    + L+++ E +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVDAELVEKLKKFRFRKETNNAAIIMKIDKDRRLVVLEEEHEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPLGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Xenopus
Match: gmfb (glia maturation factor, beta [Source:NCBI gene;Acc:549756])

HSP 1 Score: 135.191 bits (339), Expect = 2.915e-39
Identity = 60/129 (46.51%), Postives = 90/129 (69.77%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V   L E L +F+F K   N+A+I+K++K    + L+++ E +  DEL +ELP  +PR+  + Y ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    6 LVVCDVDAELVEKLKKFRFRKETNNAAIIMKIDKDRRLVVLEEEHEGISPDELKDELPERQPRYPFIFYKYQHDDGRVSYPLCFIFSSPLGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 134

[Close]

BLAST of Glia maturation factor vs. Ensembl Xenopus
Match: gmfg (glia maturation factor, gamma [Source:NCBI gene;Acc:595039])

HSP 1 Score: 54.6842 bits (130), Expect = 1.329e-9
Identity = 25/52 (48.08%), Postives = 33/52 (63.46%), Query Frame = 2

Query:  350 PYCLIFSTPI---GCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            P   IF   +   GCKPE QMMYAGS N LV   ++TK FE+RN  +++ +W
Sbjct:    1 PLAFIFHLVLFFAGCKPEQQMMYAGSKNRLVQTAELTKVFEIRNTSDLTEDW 52

[Close]

BLAST of Glia maturation factor vs. Ensembl Mouse
Match: Gmfb (glia maturation factor, beta [Source:MGI Symbol;Acc:MGI:1927133])

HSP 1 Score: 150.599 bits (379), Expect = 3.010e-45
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Mouse
Match: Gmfg (glia maturation factor, gamma [Source:MGI Symbol;Acc:MGI:1927135])

HSP 1 Score: 137.502 bits (345), Expect = 2.769e-40
Identity = 62/129 (48.06%), Postives = 89/129 (68.99%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V   LKE L +F+F K   N+A+I+KV+K    + L+ +L+++  +EL  ELP  +PRFVV SY +   DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+R  ++++  W
Sbjct:    5 LVVCEVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDELQNISPEELKLELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTETW 133

[Close]

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V   LKE L +F+F K   N+A+I+KV+K    + L+ +L+++  +EL  ELP  +PRFVV SY +   DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+R  ++++  W
Sbjct:    5 LVVCEVDPELKETLRKFRFRKETNNAAIIMKVDKDRQMVVLEDELQNISPEELKLELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTETW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Mouse
Match: Gmfb (glia maturation factor, beta [Source:MGI Symbol;Acc:MGI:1927133])

HSP 1 Score: 137.887 bits (346), Expect = 3.409e-40
Identity = 66/141 (46.81%), Postives = 94/141 (66.67%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLS------------YVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PR+  LS            Y ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    6 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRYPFLSGLEIFVRYQDFIYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 146

[Close]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Match: sp|Q9CQI3|GMFB_MOUSE (Glia maturation factor beta OS=Mus musculus OX=10090 GN=Gmfb PE=1 SV=3)

HSP 1 Score: 150.599 bits (379), Expect = 2.106e-44
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDERLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Match: sp|Q5R6P6|GMFB_PONAB (Glia maturation factor beta OS=Pongo abelii OX=9601 GN=GMFB PE=2 SV=3)

HSP 1 Score: 150.214 bits (378), Expect = 2.152e-44
Identity = 66/129 (51.16%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Match: sp|P60983|GMFB_HUMAN (Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2)

HSP 1 Score: 150.214 bits (378), Expect = 2.152e-44
Identity = 66/129 (51.16%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Match: sp|P60984|GMFB_BOVIN (Glia maturation factor beta OS=Bos taurus OX=9913 GN=GMFB PE=1 SV=2)

HSP 1 Score: 150.214 bits (378), Expect = 2.152e-44
Identity = 66/129 (51.16%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Match: sp|Q63228|GMFB_RAT (Glia maturation factor beta OS=Rattus norvegicus OX=10116 GN=Gmfb PE=1 SV=2)

HSP 1 Score: 150.214 bits (378), Expect = 2.247e-44
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDKRLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPLGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. TrEMBL
Match: G1SLX0 (Glia maturation factor OS=Oryctolagus cuniculus OX=9986 GN=GMFB PE=3 SV=3)

HSP 1 Score: 150.984 bits (380), Expect = 4.139e-42
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. TrEMBL
Match: A0A2Y9S0H4 (Glia maturation factor OS=Physeter macrocephalus OX=9755 GN=GMFB PE=3 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 4.139e-42
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. TrEMBL
Match: A7VJ98 (Glia maturation factor OS=Mus musculus OX=10090 GN=Gmfb PE=2 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 4.369e-42
Identity = 67/129 (51.94%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE V  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETHNAAIIMKIDKDKRLVVLDEELEGVSPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. TrEMBL
Match: A0A1S3I3D4 (glia maturation factor gamma isoform X1 OS=Lingula unguis OX=7574 GN=LOC106160664 PE=3 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 6.042e-42
Identity = 69/127 (54.33%), Postives = 92/127 (72.44%), Query Frame = 2

Query:  116 ICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            +C V   +KE + +FKF K K N+A+I+K++   M + LD+++ED  +D+L NELP H+PRFVV SY +   DGR+SYP C IF +PIGCKPE+QMMYAGS N LV    +TK FEVRN EE++ EW
Sbjct:    7 VCEVEPKIKETMRKFKFRKEKNNAAVILKIDMENMTVVLDEEIEDCTMDDLQNELPDHQPRFVVYSYCYNHDDGRVSYPLCFIFVSPIGCKPEMQMMYAGSKNGLVQELDVTKIFEVRNTEELTEEW 133

[Close]

BLAST of Glia maturation factor vs. TrEMBL
Match: A0A5E4BNL1 (Glia maturation factor OS=Marmota monax OX=9995 GN=MONAX_5E045418 PE=3 SV=1)

HSP 1 Score: 150.214 bits (378), Expect = 6.378e-42
Identity = 66/129 (51.16%), Postives = 95/129 (73.64%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V+E L E L +F+F K   N+A+I+K++K    + LD++LE +  DEL +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    5 LVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Cavefish
Match: GMFG (glia maturation factor gamma [Source:NCBI gene;Acc:103032687])

HSP 1 Score: 140.198 bits (352), Expect = 2.166e-41
Identity = 61/129 (47.29%), Postives = 91/129 (70.54%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V  SL+E L +F+F K   N+A+++K++     + L+++ ED+ +D+L  ELP  +PR++V SY     DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN +++S EW
Sbjct:    5 LVVCEVDPSLQEKLKKFRFRKETNNAAILMKIDMEKQLVILEEEYEDISLDDLREELPERQPRYIVYSYKLTHGDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQSAELTKVFEIRNADDLSEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Cavefish
Match: gmfb (glia maturation factor, beta [Source:ZFIN;Acc:ZDB-GENE-040426-2114])

HSP 1 Score: 126.331 bits (316), Expect = 4.843e-36
Identity = 63/129 (48.84%), Postives = 90/129 (69.77%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V   L + L  F+F K +TN+A I+K++K    + LD++ ED+  D+L +ELP  +P FVV SY ++  DGR+SYP C IFS+P+ CKPE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    4 LVVCEVDGDLVKKLRDFRFRK-ETNNAAIIKIDKDRQLVILDEEHEDISPDDLKDELPERQP-FVVYSYKYQHDDGRVSYPLCFIFSSPV-CKPEQQMMYAGSKNKLVQTVELTKVFEIRNTEDLTEEW 129

[Close]

BLAST of Glia maturation factor vs. Ensembl Cavefish
Match: GMFG (glia maturation factor gamma [Source:NCBI gene;Acc:103032687])

HSP 1 Score: 121.324 bits (303), Expect = 4.966e-33
Identity = 54/115 (46.96%), Postives = 80/115 (69.57%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITK 454
            L++C V  SL+E L +F+F K   N+A+++K++     + L+++ ED+ +D+L  ELP  +PR++V SY     DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK
Sbjct:    5 LVVCEVDPSLQEKLKKFRFRKETNNAAILMKIDMEKQLVILEEEYEDISLDDLREELPERQPRYIVYSYKLTHGDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQSAELTK 119

[Close]

BLAST of Glia maturation factor vs. Ensembl Cavefish
Match: GMFG (glia maturation factor gamma [Source:NCBI gene;Acc:103032687])

HSP 1 Score: 113.62 bits (283), Expect = 4.769e-31
Identity = 57/131 (43.51%), Postives = 83/131 (63.36%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVN--KTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V  SL+E L +F+F K   N+A+++K++  K L+ LE + ++   D    C         ++V SY     DGR+SYP C IFS+P+GCKPE QMMYAGS N LV   ++TK FE+RN +++S EW
Sbjct:   10 LVVCEVDPSLQEKLKKFRFRKETNNAAILMKIDMEKQLVILEEEYEVGSRDPSVCCT--------YIVYSYKLTHGDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQSAELTKVFEIRNADDLSEEW 132

[Close]

BLAST of Glia maturation factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009361.1 (pep scaffold:Pmarinus_7.0:GL479248:6603:17236:1 gene:ENSPMAG00000008467.1 transcript:ENSPMAT00000009361.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.51 bits (358), Expect = 6.238e-43
Identity = 61/129 (47.29%), Postives = 92/129 (71.32%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V + LK+ L +F+F K  TN+A+I+K++K    + ++++ ED+  ++L  ELP  +PRF++ SY +   DGRISYP C IF +P+GCKPE QMMYAGS N LV   ++TK FE+R+ EE++ EW
Sbjct:    5 LVVCEVDQGLKDKLKKFRFRKETTNAAIIMKIDKDRQVVVMEEEYEDISPEDLKEELPERQPRFILYSYKYHHTDGRISYPLCFIFCSPLGCKPEQQMMYAGSKNTLVQTAELTKVFEIRSVEELTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Nematostella
Match: EDO33005 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STG9])

HSP 1 Score: 125.946 bits (315), Expect = 3.124e-36
Identity = 60/127 (47.24%), Postives = 86/127 (67.72%), Query Frame = 2

Query:  116 ICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            IC+V   L +   +F+  K KTN+ALI+K++     ++ D+  ED+ +D+L +ELP H P +V+ SY +K  DGR+SYP C IF +P GCKPELQMMYAGS  NL+     TK FE+R+ EE++ +W
Sbjct:    7 ICDVDPELVKNAKKFRLRKEKTNAALIMKIDVEKQVIKEDELHEDISIDDLRDELPEHLPSYVLFSYCYKHDDGRVSYPLCFIFISPQGCKPELQMMYAGSKLNLIKELDATKIFELRSLEELTEDW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Medaka
Match: ENSORLT00000006312.2 (glia maturation factor gamma [Source:NCBI gene;Acc:101165330])

HSP 1 Score: 144.821 bits (364), Expect = 3.068e-43
Identity = 64/129 (49.61%), Postives = 92/129 (71.32%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C V ESLKE L +F+F K   N+A+++K++     + L+++ ED+ ++EL NELP  +PRF+V SY +   DGR+SYP C IFS+P+GCKPE QMMYAGS N LV    +TK FE RN ++++ EW
Sbjct:    5 LVVCEVDESLKEKLKKFRFRKETNNAAILMKIDMKKQLVILEEEYEDISMEELRNELPERQPRFIVYSYKYVHADGRVSYPLCFIFSSPMGCKPEQQMMYAGSKNRLVQSADLTKVFETRNVDDLTEEW 133

[Close]

BLAST of Glia maturation factor vs. Ensembl Medaka
Match: gmfb (glia maturation factor beta [Source:NCBI gene;Acc:105356882])

HSP 1 Score: 145.976 bits (367), Expect = 7.280e-43
Identity = 63/129 (48.84%), Postives = 94/129 (72.87%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V E L + L QF+F K   N+A+++K++K    + LD++ ED+  D+L +ELP  +PRF+V SY ++  DGR+SYP C IFS+P+GC+PE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:   62 LVVCDVDEDLVKKLRQFRFRKETNNAAIVMKIDKDRQLVILDEEHEDISPDDLKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCRPEQQMMYAGSKNKLVQTVELTKVFEIRNTEDLTEEW 190

[Close]

BLAST of Glia maturation factor vs. Ensembl Medaka
Match: gmfb (glia maturation factor beta [Source:NCBI gene;Acc:105356882])

HSP 1 Score: 127.487 bits (319), Expect = 1.697e-36
Identity = 58/129 (44.96%), Postives = 87/129 (67.44%), Query Frame = 2

Query:  110 LIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            L++C+V E L + L QF+F K   N+A+++K++K    + LD++ ED+  D+L +ELP          Y ++  DGR+SYP C IFS+P+GC+PE QMMYAGS N LV   ++TK FE+RN E+++ EW
Sbjct:    4 LVVCDVDEDLVKKLRQFRFRKETNNAAIVMKIDKDRQLVILDEEHEDISPDDLKDELPER-------HYKYQHDDGRVSYPLCFIFSSPVGCRPEQQMMYAGSKNKLVQTVELTKVFEIRNTEDLTEEW 125

[Close]

BLAST of Glia maturation factor vs. Planmine SMEST
Match: SMESG000079306.1 (SMESG000079306.1)

HSP 1 Score: 195.282 bits (495), Expect = 1.129e-63
Identity = 93/93 (100.00%), Postives = 93/93 (100.00%), Query Frame = 2

Query:  218 MELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 496
            MELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW
Sbjct:    1 MELELDQKLEDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPELQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEW 93

The following BLAST results are available for this feature:

BLAST of Glia maturation factor vs. Ensembl Human
BLAST of Glia maturation factor vs. Ensembl Celegans
BLAST of Glia maturation factor vs. Ensembl Fly
BLAST of Glia maturation factor vs. Ensembl Zebrafish
BLAST of Glia maturation factor vs. Ensembl Xenopus
BLAST of Glia maturation factor vs. Ensembl Mouse
BLAST of Glia maturation factor vs. UniProt/SwissProt
BLAST of Glia maturation factor vs. TrEMBL
BLAST of Glia maturation factor vs. Ensembl Cavefish
BLAST of Glia maturation factor vs. Ensembl Sea Lamprey
BLAST of Glia maturation factor vs. Ensembl Yeast
BLAST of Glia maturation factor vs. Ensembl Nematostella
BLAST of Glia maturation factor vs. Ensembl Medaka
BLAST of Glia maturation factor vs. Planmine SMEST

BLAST of Glia maturation factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GMFB	4.481e-45	51.16	glia maturation factor beta [Source:HGNC Symbol;Ac...	[more]
GMFB	4.481e-45	51.16	glia maturation factor beta [Source:HGNC Symbol;Ac...	[more]
GMFB	3.435e-43	50.77	glia maturation factor beta [Source:HGNC Symbol;Ac...	[more]
GMFG	4.698e-39	46.51	glia maturation factor gamma [Source:HGNC Symbol;A...	[more]
GMFG	2.552e-34	48.70	glia maturation factor gamma [Source:HGNC Symbol;A...	[more]

BLAST of Glia maturation factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Y50D7A.10	1.065e-31	44.53	pep chromosome:WBcel235:III:315460:321721:1 gene:W...	[more]

BLAST of Glia maturation factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
GMF	1.035e-31	42.52	gene:FBgn0028894 transcript:FBtr0080851	[more]

BLAST of Glia maturation factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
gmfb	4.855e-42	49.61	glia maturation factor, beta [Source:ZFIN;Acc:ZDB-...	[more]

BLAST of Glia maturation factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3


Match Name	E-value	Identity	Description
gmfb	3.469e-42	48.84	glia maturation factor, beta [Source:NCBI gene;Acc...	[more]
gmfb	2.915e-39	46.51	glia maturation factor, beta [Source:NCBI gene;Acc...	[more]
gmfg	1.329e-9	48.08	glia maturation factor, gamma [Source:NCBI gene;Ac...	[more]

BLAST of Glia maturation factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Gmfb	3.010e-45	51.94	glia maturation factor, beta [Source:MGI Symbol;Ac...	[more]
Gmfb	3.010e-45	51.94	glia maturation factor, beta [Source:MGI Symbol;Ac...	[more]
Gmfg	2.769e-40	48.06	glia maturation factor, gamma [Source:MGI Symbol;A...	[more]
Gmfg	2.769e-40	48.06	glia maturation factor, gamma [Source:MGI Symbol;A...	[more]
Gmfb	3.409e-40	46.81	glia maturation factor, beta [Source:MGI Symbol;Ac...	[more]

BLAST of Glia maturation factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9CQI3\|GMFB_MOUSE	2.106e-44	51.94	Glia maturation factor beta OS=Mus musculus OX=100...	[more]
sp\|Q5R6P6\|GMFB_PONAB	2.152e-44	51.16	Glia maturation factor beta OS=Pongo abelii OX=960...	[more]
sp\|P60983\|GMFB_HUMAN	2.152e-44	51.16	Glia maturation factor beta OS=Homo sapiens OX=960...	[more]
sp\|P60984\|GMFB_BOVIN	2.152e-44	51.16	Glia maturation factor beta OS=Bos taurus OX=9913 ...	[more]
sp\|Q63228\|GMFB_RAT	2.247e-44	51.94	Glia maturation factor beta OS=Rattus norvegicus O...	[more]

BLAST of Glia maturation factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G1SLX0	4.139e-42	51.94	Glia maturation factor OS=Oryctolagus cuniculus OX...	[more]
A0A2Y9S0H4	4.139e-42	51.94	Glia maturation factor OS=Physeter macrocephalus O...	[more]
A7VJ98	4.369e-42	51.94	Glia maturation factor OS=Mus musculus OX=10090 GN...	[more]
A0A1S3I3D4	6.042e-42	54.33	glia maturation factor gamma isoform X1 OS=Lingula...	[more]
A0A5E4BNL1	6.378e-42	51.16	Glia maturation factor OS=Marmota monax OX=9995 GN...	[more]

BLAST of Glia maturation factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
GMFG	2.166e-41	47.29	glia maturation factor gamma [Source:NCBI gene;Acc...	[more]
gmfb	4.843e-36	48.84	glia maturation factor, beta [Source:ZFIN;Acc:ZDB-...	[more]
GMFG	4.966e-33	46.96	glia maturation factor gamma [Source:NCBI gene;Acc...	[more]
GMFG	4.769e-31	43.51	glia maturation factor gamma [Source:NCBI gene;Acc...	[more]

BLAST of Glia maturation factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000009361.1	6.238e-43	47.29	pep scaffold:Pmarinus_7.0:GL479248:6603:17236:1 ge...	[more]

BLAST of Glia maturation factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Glia maturation factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO33005	3.124e-36	47.24	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Glia maturation factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSORLT00000006312.2	3.068e-43	49.61	glia maturation factor gamma [Source:NCBI gene;Acc...	[more]
gmfb	7.280e-43	48.84	glia maturation factor beta [Source:NCBI gene;Acc:...	[more]
gmfb	1.697e-36	44.96	glia maturation factor beta [Source:NCBI gene;Acc:...	[more]

BLAST of Glia maturation factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000079306.1	1.129e-63	100.00	SMESG000079306.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022205 ID=SMED30022205|Name=Glia maturation factor|organism=Schmidtea mediterranea sexual|type=transcript|length=834bp
GAAATATAATATAGTTACAAACTGATAATATTTATTTAATTGTTAATTCT
TAAGAATAACAAATATATTTTTATTAAATTTTAATTAGAATTAAATGGCT
AACACAAATTTGATAATATGCAATGTTTCTGAATCTTTAAAAGAAATTTT
AAATCAATTTAAATTTAATAAATGCAAAACCAACAGTGCTCTAATTGTTA
AAGTTAATAAGACCTTAATGGAACTTGAATTGGATCAAAAACTAGAAGAT
GTAGATGTCGATGAATTGTGTAACGAGCTACCATCCCATGAACCAAGATT
TGTTGTTTTAAGTTATGTATTCAAGCAAGTCGATGGGCGAATTTCATATC
CTTATTGTTTAATATTTTCAACCCCAATAGGCTGTAAACCTGAACTACAA
ATGATGTACGCAGGCAGCTTTAATAATCTCGTATCGATTGGTCAAATTAC
AAAGTCGTTTGAAGTAAGAAATCCCGAGGAAATATCTGTGGAATGGCTTG
AAGAAAAACTTAAATTCTTTCGTTAATTTCGTTGAAATTATTTTTACACA
TCCGTATTCATATTAATATCTGTTGGATATTTTATTGCTTCTTGTTCCTG
ATTATTTCCATCAGAAATAATATTATTTGTTTTTATAATTTTAAGTTTAA
TTGCCGATTTTCACTTTATTTGTATCGATTTTAATTATTAAATTCATTGT
TATTGAAGTTATAATGCTGTGATTGTTGTTTTATTTGTTTTTATCGATCT
GCCTCGGGTGTTTTTTGAATAGGCGTAAGGTGATGGGATACAGACATGTA
TGACTTGCATCGTTTTAGAAGGGGCTCAAAATAT

protein sequence of SMED30022205-orf-1

>SMED30022205-orf-1 ID=SMED30022205-orf-1|Name=SMED30022205-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=144bp
MANTNLIICNVSESLKEILNQFKFNKCKTNSALIVKVNKTLMELELDQKL
EDVDVDELCNELPSHEPRFVVLSYVFKQVDGRISYPYCLIFSTPIGCKPE
LQMMYAGSFNNLVSIGQITKSFEVRNPEEISVEWLEEKLKFFR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0007165	signal transduction
GO:2000249	regulation of actin cytoskeleton reorganization
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000070	intestinal phagocyte
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR002108	ADF-H
IPR029006	ADF-H/Gelsolin-like_dom_sf
IPR011171	GMF

Vocabulary: **molecular function**
Term	Definition
GO:0003779	actin binding
GO:0071933	Arp2/3 complex binding
GO:0008083	growth factor activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002108	Actin-depolymerising factor homology domain	SMART	SM00102	adf_2	coord: 13..140 e-value: 9.8E-22 score: 88.2
IPR002108	Actin-depolymerising factor homology domain	PFAM	PF00241	Cofilin_ADF	coord: 16..138 e-value: 2.0E-25 score: 88.9
IPR002108	Actin-depolymerising factor homology domain	PROSITE	PS51263	ADF_H	coord: 5..140 score: 16.787
IPR029006	ADF-H/Gelsolin-like domain superfamily	GENE3D	G3DSA:3.40.20.10		coord: 1..141 e-value: 1.0E-34 score: 121.0
IPR011171	Glia maturation factor	PIRSF	PIRSF001788	GMF-beta	coord: 1..142 e-value: 3.9E-49 score: 163.7
IPR011171	Glia maturation factor	PANTHER	PTHR11249	GLIAL FACTOR NATURATION FACTOR	coord: 4..143
IPR011171	Glia maturation factor	CDD	cd11283	ADF_GMF-beta_like	coord: 11..131 e-value: 6.25536E-52 score: 158.939
None	No IPR available	SUPERFAMILY	SSF55753	Actin depolymerizing proteins	coord: 6..140

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Glia maturation factor

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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