RING-type domain-containing protein

Overview


Name	RING-type domain-containing protein
Smed ID	SMED30022156
Length (bp)	1806

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of RING-type domain-containing protein (SMED30022156) t-SNE clustered cells

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30022156) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of RING-type domain-containing protein (SMED30022156) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for RING-type domain-containing protein (SMED30022156) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022156

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
pigment cell	SMED30022156	SMESG000064098.1	SmedASXL_015704	SmedAsxl_ww_GCZZ01	PMID:29158443 He et al., 2017
X1 cell	SMED30022156	SMESG000064098.1	SmedASXL_015704	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015

Note: Hover over icons to view figure legend

Homology

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BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 50.8322 bits (120), Expect = 3.217e-7
Identity = 31/87 (35.63%), Postives = 44/87 (50.57%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLES--------YASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            + N E+ LTCPI     ++PR L C H FC +CLE+        Y    L    K   CP CR+ T++   GI+SL  +F  + + E
Sbjct:    1 MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLK---CPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 50.447 bits (119), Expect = 3.539e-7
Identity = 31/87 (35.63%), Postives = 44/87 (50.57%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLES--------YASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            + N E+ LTCPI     ++PR L C H FC +CLE+        Y    L    K   CP CR+ T++   GI+SL  +F  + + E
Sbjct:    1 MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLK---CPNCRSITEIAPTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM59 (tripartite motif containing 59 [Source:HGNC Symbol;Acc:HGNC:30834])

HSP 1 Score: 51.6026 bits (122), Expect = 5.176e-7
Identity = 37/112 (33.04%), Postives = 53/112 (47.32%), Query Frame = 1

Query:  163 RQRNKSESCVCSKVFHKSNNEFS-SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLES--------YASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            R R K    V  +     N+E +  + N E+ LTCPI     ++PR L C H FC +CLE+        Y    L    K   CP CR+ T++   GI+SL  +F  + + E
Sbjct:    4 RIRIKDSGGVGEECIQPPNHEINKEMHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENILQASGNFYIWRPLRIPLK---CPNCRSITEIAPTGIESLPVNFALRAIIE 112

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM13 (tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976])

HSP 1 Score: 53.1434 bits (126), Expect = 9.925e-7
Identity = 32/82 (39.02%), Postives = 39/82 (47.56%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     GI SL  ++  K + E
Sbjct:    4 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGILEGSVRNSLWRPAPFKCPTCRKETS--ATGINSLQVNYSLKGIVE 83

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Human
Match: TRIM13 (tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976])

HSP 1 Score: 53.1434 bits (126), Expect = 1.021e-6
Identity = 32/82 (39.02%), Postives = 39/82 (47.56%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     GI SL  ++  K + E
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGILEGSVRNSLWRPAPFKCPTCRKETS--ATGINSLQVNYSLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 61.6178 bits (148), Expect = 1.452e-9
Identity = 35/97 (36.08%), Postives = 51/97 (52.58%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE 525
            +E +E LLTCPI L    +P+ L C H FC  CLES A    +T  + + CP CR    + + G+K+  P++    LT +L    Q     +AE +E
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCA----DTLHRNLKCPECRAEHNIPYDGVKAFQPNYT---LTGFLEIHLQATPESAAEIEE 123

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Match: nhl-1 (RING finger protein nhl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q03601])

HSP 1 Score: 61.6178 bits (148), Expect = 1.490e-9
Identity = 35/97 (36.08%), Postives = 51/97 (52.58%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE 525
            +E +E LLTCPI L    +P+ L C H FC  CLES A    +T  + + CP CR    + + G+K+  P++    LT +L    Q     +AE +E
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCA----DTLHRNLKCPECRAEHNIPYDGVKAFQPNYT---LTGFLEIHLQATPESAAEIEE 123

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Match: trim2a (tripartite motif containing 2a [Source:ZFIN;Acc:ZDB-GENE-050327-99])

HSP 1 Score: 50.8322 bits (120), Expect = 5.079e-6
Identity = 33/92 (35.87%), Postives = 46/92 (50.00%), Query Frame = 1

Query:  253 LLTCPIHLGAIDEPRQLQCGHVFCLSCLESY-ASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE 525
             L C I L   + P+ L C H FC  CL++Y  SH L  S     CP+CR  + L  KG+ +L  +F    L E L  KK    N+S ++ +
Sbjct:   20 FLICSICLDRYNNPKVLPCLHTFCERCLQNYIPSHSLTLS-----CPVCRQTSILPEKGVAALQSNFFITNLMEVL--KKSPNSNLSEDYTD 104

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: ENSXETT00000026455.1 (tripartite motif containing 59 [Source:NCBI gene;Acc:100493536])

HSP 1 Score: 58.151 bits (139), Expect = 1.853e-8
Identity = 32/83 (38.55%), Postives = 43/83 (51.81%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLE----SYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            ++N ED LTC +     D+PR L C H FC +CLE    S  S    TS   + CP CRN ++L   G  +L  +F  K + E
Sbjct:    1 MDNFEDELTCSVCYNIFDDPRILPCSHTFCRNCLEKVIHSSGSGLWRTSAAWLKCPSCRNTSELTMSGTLALPINFALKSIVE 83

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: sim2 (SIM bHLH transcription factor 2 [Source:Xenbase;Acc:XB-GENE-1013958])

HSP 1 Score: 53.1434 bits (126), Expect = 9.520e-7
Identity = 30/82 (36.59%), Postives = 40/82 (48.78%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYA---SHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CL+      S  ++  P    CP CR  T     G+  L  ++L K + E
Sbjct:    1 MEVLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLDGVLEENSRTMQWRPSSFKCPTCRKETP--TMGVNGLQVNYLLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: TRIM50 (tripartite motif containing 50 [Source:NCBI gene;Acc:100495882])

HSP 1 Score: 51.9878 bits (123), Expect = 2.285e-6
Identity = 26/59 (44.07%), Postives = 33/59 (55.93%), Query Frame = 1

Query:  226 FSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRN 402
            +SS+ +LE+ LTCPI L    EP  LQCGH FC  CL    +     S   + CP+CR 
Sbjct:    3 YSSVLHLENQLTCPICLEVFKEPLMLQCGHSFCKECLWGLMAE----SRIHLLCPVCRQ 57

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Match: TRIM50 (tripartite motif containing 50 [Source:NCBI gene;Acc:100495882])

HSP 1 Score: 51.2174 bits (121), Expect = 4.406e-6
Identity = 26/58 (44.83%), Postives = 32/58 (55.17%), Query Frame = 1

Query:  229 SSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRN 402
            S+I +LE+ LTCPI L    EP  LQCGH FC  CL       +  S   + CP+CR 
Sbjct:    3 SNIRHLENQLTCPICLEVFKEPLMLQCGHSFCKECLWGL----MAESRIHLLCPVCRQ 56

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim50 (tripartite motif-containing 50 [Source:MGI Symbol;Acc:MGI:2664992])

HSP 1 Score: 52.7582 bits (125), Expect = 9.294e-7
Identity = 24/57 (42.11%), Postives = 36/57 (63.16%), Query Frame = 1

Query:  232 SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRN 402
            ++  L+D L CPI L    EP  LQCGH +C  CL++ + H L++   ++CCP+CR 
Sbjct:    6 TVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQH-LDS---ELCCPVCRQ 58

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim50 (tripartite motif-containing 50 [Source:MGI Symbol;Acc:MGI:2664992])

HSP 1 Score: 52.7582 bits (125), Expect = 9.863e-7
Identity = 24/57 (42.11%), Postives = 36/57 (63.16%), Query Frame = 1

Query:  232 SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRN 402
            ++  L+D L CPI L    EP  LQCGH +C  CL++ + H L++   ++CCP+CR 
Sbjct:    6 TVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQH-LDS---ELCCPVCRQ 58

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim13 (tripartite motif-containing 13 [Source:MGI Symbol;Acc:MGI:1913847])

HSP 1 Score: 52.373 bits (124), Expect = 1.206e-6
Identity = 31/82 (37.80%), Postives = 39/82 (47.56%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     G+ SL  ++  K + E
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETS--ATGVNSLQVNYSLKGIVE 80

[Close]

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     G+ SL  ++  K + E
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETS--ATGVNSLQVNYSLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Match: Trim59 (tripartite motif-containing 59 [Source:MGI Symbol;Acc:MGI:1914199])

HSP 1 Score: 50.8322 bits (120), Expect = 3.760e-6
Identity = 30/87 (34.48%), Postives = 43/87 (49.43%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLES--------YASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            + N E+ LTCPI     ++PR L C H FC +CLE+        Y    L    K   CP CR+  ++   GI+SL  +F  + + E
Sbjct:    1 MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNFYIWRPLRIPLK---CPNCRSIIEIASTGIESLPVNFALRAIIE 84

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q03601|NHL1_CAEEL (RING finger protein nhl-1 OS=Caenorhabditis elegans OX=6239 GN=nhl-1 PE=1 SV=2)

HSP 1 Score: 61.6178 bits (148), Expect = 1.896e-8
Identity = 35/97 (36.08%), Postives = 51/97 (52.58%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE 525
            +E +E LLTCPI L    +P+ L C H FC  CLES A    +T  + + CP CR    + + G+K+  P++    LT +L    Q     +AE +E
Sbjct:   34 LEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCA----DTLHRNLKCPECRAEHNIPYDGVKAFQPNYT---LTGFLEIHLQATPESAAEIEE 123

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|O60858|TRI13_HUMAN (E3 ubiquitin-protein ligase TRIM13 OS=Homo sapiens OX=9606 GN=TRIM13 PE=1 SV=2)

HSP 1 Score: 53.1434 bits (126), Expect = 4.901e-6
Identity = 32/82 (39.02%), Postives = 39/82 (47.56%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     GI SL  ++  K + E
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGILEGSVRNSLWRPAPFKCPTCRKETS--ATGINSLQVNYSLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|F6ZQ54|TRI13_XENTR (Tripartite motif containing 13 OS=Xenopus tropicalis OX=8364 GN=trim13 PE=3 SV=1)

HSP 1 Score: 53.1434 bits (126), Expect = 5.044e-6
Identity = 30/82 (36.59%), Postives = 40/82 (48.78%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYA---SHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CL+      S  ++  P    CP CR  T     G+  L  ++L K + E
Sbjct:    1 MEVLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLDGVLEENSRTMQWRPSSFKCPTCRKETP--TMGVNGLQVNYLLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q810I2|TRI50_MOUSE (E3 ubiquitin-protein ligase TRIM50 OS=Mus musculus OX=10090 GN=Trim50 PE=1 SV=1)

HSP 1 Score: 52.7582 bits (125), Expect = 6.899e-6
Identity = 24/57 (42.11%), Postives = 36/57 (63.16%), Query Frame = 1

Query:  232 SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRN 402
            ++  L+D L CPI L    EP  LQCGH +C  CL++ + H L++   ++CCP+CR 
Sbjct:    6 TVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQH-LDS---ELCCPVCRQ 58

[Close]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CYB0|TRI13_MOUSE (E3 ubiquitin-protein ligase TRIM13 OS=Mus musculus OX=10090 GN=Trim13 PE=2 SV=1)

HSP 1 Score: 52.373 bits (124), Expect = 8.434e-6
Identity = 31/82 (37.80%), Postives = 39/82 (47.56%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETS---PKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            +E LE+ LTCPI     D+PR L C H FC  CLE      +  S   P    CP CR  T     G+ SL  ++  K + E
Sbjct:    1 MELLEEDLTCPICCSLFDDPRVLPCSHNFCKKCLEGLLEGNVRNSLWRPSPFKCPTCRKETS--ATGVNSLQVNYSLKGIVE 80

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267ECL9 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g1 PE=4 SV=1)

HSP 1 Score: 163.31 bits (412), Expect = 2.638e-39
Identity = 135/549 (24.59%), Postives = 237/549 (43.17%), Query Frame = 1

Query:  214 SNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESY--------------ASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE---LHVTSSNNIFKTKLQLMNQLLND-IKTKDLSLDVLSPESNENFIQNLTEVLEKHNI-----------PKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKS---------FDETT------------------IRKNMRKYREYTLEKYFLNHIDTSVIGIT-SIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQS----SCLIQLSLNG------ERENISPIYS-GLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPN 1656
            S +   S+E LE+L TC IHLG + +PR L C HVFCL+CL  +              ASHG       + CPLCR   +L   G+++L  +  H+ + +Y+  +  + L +S   D       ++     + K +++  L  D ++  +L  D           +NL +++ + +            P +P N R R     +        S    + +           D+ T                  IR NMR++  Y L++     +D    G    I    ++   +D++ +I +   S  + L +S+  +L+ F + +   ++   ++      ++VSG +  D +    S ++ + L+G      ER   +      LF GF  D     + VA P+  +V  L  +L +    F F NL P  V  + + R +WVSCP++G I + ++ T  Y  L T QI++S P HII T D R++F D  + R+FWI R +  +++Q +     +E   I  +  + E+ IL     K +  +P 
Sbjct:   62 SEDSSGSVEQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHG------SLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRLDAEDGATRGKLGNPAQP-NRRGRDARQPLPPPPPPPPSATAQQHQQPPSLPSRYPRDDATSDESSEEAEEEDALDLSFIRHNMRRHSSYKLKEIETGFLDLQHPGAGLEIGAAGLIADPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPSDSATRWTSAIVCVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF--LQELADITGIAPLGEDKILVCTKRKLYFLKPT 601

[Close]

BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267DTD7 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g2 PE=4 SV=1)

HSP 1 Score: 161.77 bits (408), Expect = 7.647e-39
Identity = 135/549 (24.59%), Postives = 236/549 (42.99%), Query Frame = 1

Query:  214 SNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESY--------------ASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE---LHVTSSNNIFKTKLQLMNQLLND-IKTKDLSLDVLSPESNENFIQNLTEVLEKHNI-----------PKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKS---------FDETT------------------IRKNMRKYREYTLEKYFLNHIDTSVIGIT-SIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQS----SCLIQLSLNG------ERENISPIYS-GLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPN 1656
            S +   S+E LE+L TC IHLG + +PR L C HVFCL+CL  +              ASHG       + CPLCR   +L   G+++L  +  H+ + +Y+  +  + L +S   D       ++     + K +++  L  D ++  +L  D           +NL +++ + +            P +P N R R     +        S    + +           D+ T                  IR NMR++  Y L++     +D    G    I    ++   +D++ +I +   S  + L +S+  +L+ F + +   ++   ++      ++VSG +  D +    S +  + L+G      ER   +      LF GF  D     + VA P+  +V  L  +L +    F F NL P  V  + + R +WVSCP++G I + ++ T  Y  L T QI++S P HII T D R++F D  + R+FWI R +  +++Q +     +E   I  +  + E+ IL     K +  +P 
Sbjct:   62 SEDSSGSVEQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHG------SLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRLDAEDGATRGKLGNPAQP-NRRGRDARQPLPPPPPPLPSATAQQHQQPPSLPSRYPRDDATSDESSEEAEEEDALDLSFIRHNMRRHSSYKLKEIETGFLDLQHPGAGLEIGAAGLIADPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFTNGLVYVSGVVPSDSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF--LQELADITGIAPLGEDKILVCTKRKLYFLKPT 601

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BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267FRC4 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig004309g3 PE=4 SV=1)

HSP 1 Score: 161.77 bits (408), Expect = 9.100e-39
Identity = 133/548 (24.27%), Postives = 237/548 (43.25%), Query Frame = 1

Query:  214 SNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESY--------------ASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE---LHVTSSNNIFKTKLQLMNQLLND-IKTKDLSLDVLSPESNENFIQNLTEVLEKHNI-----------PKKPT----NSRVRSKSVLVTNSSEFGMSY-----CDLKFKSFDETT-----------------IRKNMRKYREYTLEKYFLNHIDTSVIGIT-SIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQS----SCLIQLSLNG------ERENISPIYS-GLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPN 1656
            S +   S+E LE+L TC IHLG + +PR L C HVFCL+CL  +              ASHG       + CPLCR   +L   G+++L  +  H+ + +Y+  +  + L +S   D       ++     + K +++  L  D ++  +L  D           +NL +++ + +            P +P     ++R           S+    +        ++   D T+                 IR NMR++  Y L++     +D    G    I    ++   +D++ +I +   S  + L +S+  +L+ F + +   ++   ++      ++VSG +  D +    S +  + L+G      ER   +      LF GF  D     + VA P+  +V  L  +L +    F F NL P  V  + + R +WVSCP++G I + ++ T  Y  L T QI++S P HII T D R++F D  + R+FWI R +  +++Q +     +E   I  +  + E+ IL     K +  +P 
Sbjct:   62 SEDSSGSVEQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHG------SLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRLDAEDGATRGKLGNPAQPNRRGRDARQPLLPPPPPPPSDTAQQHQQPPSLPSRYPRDDATSDESSEEAEEEDALDLSFIRHNMRRHSSYKLKEIETGFLDLQHPGAGLEIGAAGLIADPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPSDSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF--LQELADITGIAPLGEDKILVCTKRKLYFLKPT 601

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BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A1I8IQ65 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 164.466 bits (415), Expect = 1.069e-38
Identity = 136/535 (25.42%), Postives = 238/535 (44.49%), Query Frame = 1

Query:  214 SNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESY--------------ASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDE---LHVTSSNNIFKTKLQLMNQLLND-IKTKDLSLDVLSPESNENFIQNLTEVLEKHNI-----------PKKPTNSRVRSK-------------SVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGIT-SIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQS----SCLIQLSLNG------ERENISPIY-SGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPN 1656
            S +   S+E LE+L TC IHLG + +PR L C HVFCL+CL  +              ASHG       + CPLCR   +L   G+++L  +  H+ + +Y+  +  + L +S   D       ++     + K +++  L  D ++  +L  D           +NL +++ + +            P +P N R R               +   + SS    S    +  + D + IR NMR++  Y L++     +D    G    I    ++   +D++ +I +   S  + L +S+  +L+ F + +   ++   ++      ++VSG +  D +    S +  + L+G      ER   +      LF GF  D     + VA P+  +V  L  +L +    F F NL P  V  + + R +WVSCP++G I + ++ T  Y  L T QI++S P HII T D R++F D  + R+FWI R +  +++Q +     +E   I  +  + E+ IL     K +  +P 
Sbjct: 1225 SEDSSGSVEQLEELTTCAIHLGQLSQPRLLPCSHVFCLACLARWESQQQQKKQQQQVPASHG------SLACPLCRVSVRLPPDGVRALPTAAAHQSIADYIAERHCRRLQLSLGGDSPVCARSSTRRRSLERKQEILAHLAKDFVRRSELERDAFDRAELLAVRENLNKLISRLDAEDGATRGKLGNPAQP-NRRGRDARQPLLPPPPPPPSARRSSTSSRHESSEEAEEEDALDLSFIRHNMRRHSSYKLKEIETGFLDLQHPGAGLEIGAAGLIADPEDQVDMILLNSCSHSLLLYSSQDGRLKDFPVVLGGHRMRCYYMTFSNGLVYVSGVVPSDSATRWTSAIACVQLDGLVIRRLERPGAAAGSDEPLFAGFHVDERRGELVVAQPADQKVEFLTPALARTGHWFTFENLHPHHVTWTRERRMLWVSCPSEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRVFWIIRRSEFIFVQRLEF--LQELADITGIAPLGEDKILVCTKRKLYFLKPT 1750

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BLAST of RING-type domain-containing protein vs. TrEMBL
Match: A0A267FKZ3 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014891g1 PE=4 SV=1)

HSP 1 Score: 103.99 bits (258), Expect = 1.860e-19
Identity = 59/177 (33.33%), Postives = 90/177 (50.85%), Query Frame = 1

Query: 1171 LFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKL-KCRI 1698
            LF GF  D     + VA PS  +V      L +    F F NL P +V  + + + +WVSCP +G I + ++ T  Y  L T QI++S P HII T D R++F D  + RLFW+ R +  +++Q +      +E  I  +  + E+ IL     +  + +P R  K  H+K  KC I
Sbjct:  481 LFAGFFVDSRRGDMVVAQPSDQKVEFFTPCLGRTGHWFTFENLHPQYVTWTRERKMLWVSCPAEGHILIVNDRTGVYRKLTTTQIFDSVPAHIITTSDKRIIFTDNQRQRLFWVIRRSEFIFVQRLQFLQELDE--ITGIAPLGEDKILVCTRRRICVLKPVR--KLRHRKRSKCLI 653

HSP 2 Score: 85.5001 bits (210), Expect = 1.561e-13
Identity = 46/119 (38.66%), Postives = 73/119 (61.34%), Query Frame = 1

Query:  154 ASERQRNKSESCVCSK-VFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNM 507
            A++     S SCVC +     S++   SIE+LE+L TCPIHLG + EP+ L C HVFCL+CLE + S   + S  +  CPLCR   +L   G++ L P+ +H+ + +Y+ +++ + L +
Sbjct:    7 AADDAAGSSTSCVCDQPSCASSSSSSGSIESLEELTTCPIHLGRLLEPKLLTCSHVFCLTCLEKWDSQ--QPSRDRFPCPLCRVEARLPAGGLRCLPPAHVHQSIIKYIVDRQCRRLQL 123

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BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000043988.1 (RING finger protein 223-like [Source:NCBI gene;Acc:111194248])

HSP 1 Score: 48.9062 bits (115), Expect = 3.814e-6
Identity = 25/72 (34.72%), Postives = 38/72 (52.78%), Query Frame = 1

Query:  292 PRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNM 507
            P+ L+C H FCL CL       ++  P+ I CPLCR +T L   G+  LA      ++  YL +  Q+V ++
Sbjct:   49 PKMLECKHTFCLECLARMNVKSMQ--PESIQCPLCRAYTHLPAMGLPKLA---TDPKVLSYLPDAMQRVYSI 115

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BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Match: TRIM50 (tripartite motif containing 50 [Source:NCBI gene;Acc:103044686])

HSP 1 Score: 49.6766 bits (117), Expect = 7.715e-6
Identity = 24/57 (42.11%), Postives = 33/57 (57.89%), Query Frame = 1

Query:  232 SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSP-KQICCPLCR 399
            S+E LE+ L CP+ L    EP  LQCGH +C  C+ S     ++  P  Q+ CP+CR
Sbjct:    6 SLEPLEEQLRCPVCLEVFSEPLMLQCGHSYCRGCVRS-----MDMDPLGQLQCPVCR 57

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Query:  232 SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSP-KQICCPLCR 399
            S+E LE+ L CP+ L    EP  LQCGH +C  C+ S     ++  P  Q+ CP+CR
Sbjct:    6 SLEPLEEQLRCPVCLEVFSEPLMLQCGHSYCRGCVRS-----MDMDPLGQLQCPVCR 57

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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010730.1 (pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 gene:ENSPMAG00000009719.1 transcript:ENSPMAT00000010730.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.1358 bits (113), Expect = 1.670e-7
Identity = 28/74 (37.84%), Postives = 36/74 (48.65%), Query Frame = 1

Query:  244 LEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQIC-----CPLCRNHTQLDHKGIKSLAPSF 450
            LE+ LTCP+     ++PR L C H FC  CLE      L  SP +       CP CR+  +L   G  SL  +F
Sbjct:    4 LEEELTCPVCYSLFEDPRVLPCSHTFCRGCLEDILQGSLHLSPWRPLRTPFKCPSCRHVCELPLTGFTSLPVNF 77

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BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Match: trim59 (tripartite motif containing 59 [Source:ZFIN;Acc:ZDB-GENE-060724-2])

HSP 1 Score: 49.6766 bits (117), Expect = 1.088e-6
Identity = 30/94 (31.91%), Postives = 47/94 (50.00%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQ------ICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKV 498
            +E+LE+ LTCP+     +EPR L C H FC  CLES     +E  P        + CP CR+   +   G+  L  ++    + E  + ++QK+
Sbjct:    1 MEHLEEDLTCPVCFSLFEEPRVLPCSHTFCRRCLESVLQATVEQFPLWRALRVPLKCPSCRHMFDMPSAGLSYLPLNYSLVAIVEK-YRRQQKL 93

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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO41454 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4D3])

HSP 1 Score: 49.2914 bits (116), Expect = 8.009e-8
Identity = 28/74 (37.84%), Postives = 37/74 (50.00%), Query Frame = 1

Query:  250 DLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTE 471
            D L CPI L    EP+ L C H  C  CLE  A+     S + I CPLCR+   +   G+K+L  +    +L E
Sbjct:    6 DELLCPICLDEFKEPKTLSCMHDLCRKCLEDMAAR---ESSRVIRCPLCRSEIDIPRGGVKNLPTNLRLMKLVE 76

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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO33043 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STB0])

HSP 1 Score: 48.1358 bits (113), Expect = 2.606e-7
Identity = 24/63 (38.10%), Postives = 36/63 (57.14%), Query Frame = 1

Query:  256 LTCPIHLGAIDEPRQLQ-CGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLA 441
            ++CP+ L   +EP  L  CGH  CL CL++        +P  + CP+CR+ + L   G+KSLA
Sbjct:   21 ISCPVCLEVFEEPLVLPSCGHSVCLQCLQNMTKR----NPPSLLCPVCRSESVLGENGLKSLA 79

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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO34308 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPQ3])

HSP 1 Score: 52.373 bits (124), Expect = 4.466e-7
Identity = 27/88 (30.68%), Postives = 46/88 (52.27%), Query Frame = 1

Query:  235 IENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKV 498
            +E + D L C I L  + EPR L C H FC  C++  +++    S   + CP CR  T +   G++SL  +F   Q+ + + +K  ++
Sbjct:    8 LEQINDQLVCAICLDRLVEPRLLICMHTFCTPCIQRISNNDASAS---LTCPTCRKETPIPETGVESLHLNFFVNQMLDVVRHKADEL 92

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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO30256 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1B7])

HSP 1 Score: 51.6026 bits (122), Expect = 7.676e-7
Identity = 26/74 (35.14%), Postives = 38/74 (51.35%), Query Frame = 1

Query:  256 LTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYL 477
            +TC + LG   +PR L C H +C  CLES   H  E +   + CP CR   ++  + +KSL   F+   L E +
Sbjct:   14 VTCSLCLGQYQDPRVLACLHTYCRHCLESLVEHSKECT---VSCPQCREKIEISVEEVKSLKVDFMLIDLIEKM 84

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BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Match: EDO33238 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SSS6])

HSP 1 Score: 49.2914 bits (116), Expect = 1.721e-6
Identity = 27/75 (36.00%), Postives = 40/75 (53.33%), Query Frame = 1

Query:  229 SSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFL 453
            S+   LED +TC I +  +++PR L C H FC  CLE  A H       ++ CPLC+   Q+    + SL  +F+
Sbjct:    4 SASRRLEDEVTCSICIEHLNDPRVLPCLHSFCRHCLEELAVHS--EGRGKLVCPLCKAEFQISPADVPSLKVNFM 76

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BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000015094.2 (pep primary_assembly:ASM223467v1:17:17654645:17656708:1 gene:ENSORLG00000012054.2 transcript:ENSORLT00000015094.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 49.2914 bits (116), Expect = 2.739e-7
Identity = 24/52 (46.15%), Postives = 31/52 (59.62%), Query Frame = 1

Query:  244 LEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCR 399
            LE+LLTCP+      +PRQL CGH  CLSCL +   H  ++  +   CP CR
Sbjct:    9 LEELLTCPVCQDIFSDPRQLPCGHSMCLSCLNNLLDHSSDSPLR---CPDCR 57

[Close]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000019661.2 (pep primary_assembly:ASM223467v1:13:32568675:32574156:1 gene:ENSORLG00000015701.2 transcript:ENSORLT00000019661.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.8322 bits (120), Expect = 5.654e-7
Identity = 24/65 (36.92%), Postives = 35/65 (53.85%), Query Frame = 1

Query:  205 FHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCR 399
            F++ ++  S     ED   CP+ L  + +P  L CGH +CLSC++S+     E S  Q  CP CR
Sbjct:    4 FNRGSSVMSEAWTGEDSFACPVCLDVLKDPTTLPCGHSYCLSCIQSHWDK--ELSKGQYSCPQCR 66

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 1063.52 bits (2749), Expect = 0.000e+0
Identity = 540/540 (100.00%), Postives = 540/540 (100.00%), Query Frame = 1

Query:   82 MLKKLIISNMNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL 1701
            MLKKLIISNMNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL
Sbjct:    1 MLKKLIISNMNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL 540

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000064098.1 (SMESG000064098.1)

HSP 1 Score: 1046.19 bits (2704), Expect = 0.000e+0
Identity = 531/531 (100.00%), Postives = 531/531 (100.00%), Query Frame = 1

Query:  109 MNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL 1701
            MNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL
Sbjct:    1 MNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSLNGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL 531

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000020467.1 (SMESG000020467.1)

HSP 1 Score: 213.001 bits (541), Expect = 2.144e-61
Identity = 162/541 (29.94%), Postives = 266/541 (49.17%), Query Frame = 1

Query:  160 ERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVL-----NMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVL--VTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQTNXXXXXXXXXXXXXXXXXXPEI----CLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKI----GLDQSSCLIQLSLNGERENISPIYSG-----LFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEI---KINTVQSISE----NMILFSDGNKTFIARPNRSPKEEHQKLKCRIL 1701
            +R RN+S     + + H   N   S+  LEDL+ CPIHLG +++PR L CGH FCL+CL  Y+     +      CP+CR + ++D K +  L PS   KQLT+Y+   K ++      NM    +E  + S +     K +L+  L+     +++S    S  + E F + L  +     I  +P+ S     ++L  VTN   F  +Y     +  D  TIR+NMRKY EY L    L  ++ S++   S  +  ++      ++    +     +        +    +  F I +++ ++ PIF+K + N +F+SG I      ++   LIQ SL GE  + S   S         GF  D  +  I +A P   ++ +L ++L +    + F +L P F+  +  T EIW SCP DGRI + DE T +Y  L T+QIY + P+HI  + D+R++FLD  ++R+FW+ + N  + IQ IN  G   +    K+  + +IS       +LF  G+  ++ RP ++   ++ KL C IL
Sbjct:   20 KRDRNRSYLEDNNLLKHLKRNSRMSMSKLEDLIMCPIHLGMMEDPRILPCGHAFCLNCL--YSCLIRMSISVNFSCPVCRRYCEIDQKTVCLLPPSIATKQLTDYIVETKSRLFMKQHPNMEYLSNESIIESISTTVDQKRELVKHLI-----REISEYTKSKSNQEQFHEILKSIDTPLVIESQPSESE---NAILHSVTNMEIFNSNY-----ELMDVETIRENMRKYSEYKL----LRDVNHSIVNFHSSGRNKMIIADIKLLNHEAEVIVWTSVHGNLIAVKTPDHSVHDFTIQIDSCEVKPIFLKIYNNDLFLSGYIENSATKEKHYYLIQSSLTGELIHTSVFNSSHDITTKIAGFHIDPGSGKILLAIPDACKIAILTSNLVETSHGYHFTDLHPSFITQNQDTAEIWASCPQDGRIIIIDEETGSYRQLGTDQIYNAIPSHITISGDNRVMFLDCRQNRVFWVRKRNDFILIQRINFIGHHNKQLNGKMTAMVAISGTDTLGRLLFVIGSNAYLVRPAKAIGGQNHKL-CNIL 540

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000081132.1 (SMESG000081132.1)

HSP 1 Score: 155.606 bits (392), Expect = 9.441e-41
Identity = 151/521 (28.98%), Postives = 242/521 (46.45%), Query Frame = 1

Query:  157 SERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQ---ICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLN--MSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIG--ITSIHQTNXXXXXXXXXXXXXXXXXXPEICLANSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKI-----GLDQSSCLIQLSLNGERENISPIYSGL------FGGFCFDLTNNSIFVAYPSRNQVILLDNSL-EKELK-VFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKINTVQSI--SENMILFSDGNKTFIARP 1653
            +ER+ +KS      K F    N     E LED+++CPIHLG ++ P QL CGH FCL C+E      L+T   Q     CP+CR    +  +G      S+    +  Y+  +KQK L+   S ++   +    N+I + K  ++ +L  DI  K LS   +        I  L  +L+K   P  P N+        V NS     S+ +LK ++  E T R+ M K  EY   K     +   V+   + S  + ++    D +   +  +  S EI + +       SF     +  + P+F++ F + +FVSG I     G   +  L++ SL+G+  + S  Y+          GF  D T  ++++A P    + ++ + L E E K VF    L P FV     T+EIW SCP    I + D +T +Y+   T Q++ S P HII T D+++ FLD   SR+FWI R N  L IQ +    + ++   + ++    S  ++L +D +  F A+P
Sbjct:    6 TERRFSKSLQLEEQKDFLARKNSILPSEPLEDMVSCPIHLGILERPIQLPCGHSFCLECIE----RCLKTQMLQNNHFACPVCRVSWPVPLEGAHGWPQSYALNDIITYVQEEKQKKLSGKSSQKYRNSNSNRKNSIIE-KADIVKKLAEDIANKKLSDGSVD---KAFLITELNSILKKLQEPSTPVNN--------VENSGSRRSSF-ELKIET--EVT-REQMSKLCEY---KVIQERLSEEVLKELMKSPAKDSVDLDEDPQFRKLVFVNTSHEIVIYDCNTETSTSFVPMYYSDCLKPVFLRFFQDLVFVSGLIYSKDDGSVLAGVLVKYSLDGKMIDASQRYTKQNNEYLPVHGFDID-TQGNVYLAQPDMATITVMTSDLKENEDKFVFNEPELHPTFVCFCKLTKEIWASCPAHKSILILDSVTGSYMQFGTIQLFNSEPAHIISTQDNKICFLDSKLSRVFWIKRQNEYLCIQRLAFGTTLKKANFSLLRGFCNSSALLLITDKS-VFTAKP 501

[Close]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Match: SMESG000069646.1 (SMESG000069646.1)

HSP 1 Score: 118.242 bits (295), Expect = 6.172e-28
Identity = 117/503 (23.26%), Postives = 221/503 (43.94%), Query Frame = 1

Query:  142 TIKGASERQRNKSESCVCSKVFHKSNNEFSSIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQICCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELHVTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEKHNIPKKPTNSRVRSKSVLVTNSSE------------FGMSYCDLKFKSFDETTIRKNMRKYREYTLEKYFLNHIDTSVIGITSIHQ----TNXXXXXXXXXXXXXXXXXXPEICLANSRGLKL--------RSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQ--SSCLIQLSLNGERENISPIYSG-------LFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKVFEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYESTPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLIN 1551
            ++  ++  ++N+ ++    ++  +S   F +   LE+++TC IHLG +++PR+L C H FC +CL+ Y+   ++     + CP+CR   + +   I  L  +   KQL                    + V   N I K            I+   +S   LS E  E+ +Q+L + +  +N   K +    +S  V V+ SS+               S  DL ++  D  TIR+NM KY +Y + K      D       +IHQ    ++  + S   I++         + L +S+  +L        ++F I ++N  I P +I+ +   + ++G++  ++   S  +Q S+ G+    S +Y         +  GF  +      ++  P+   V +   +  +  + +EF    P ++A S    ++W+SCP + RI + D  +  +    T QI ++ P  I  T D +++FLD+  +R  WI R N  +  Q +N
Sbjct:   16 SVSESASSEQNEVKNSQLQRITRRSET-FDNTRELEEIVTCCIHLGIMNDPRKLFCQHAFCYNCLKEYSKICVD-----LICPICRVKEKTN--DIDKLPSALTEKQL--------------------ISVVMKNRITKC-----------IEDPQISKG-LSDEIKEDLVQHLVKEINLNNRVYKVS----KSDEVFVSTSSQNTNQITAYLESNQNTSIDDLTYEMMDIETIRENMLKYSQYEVVKR-----DGVHKICKNIHQLQKESSQFEFSIFDINISATHPKLSHLVLVDSKSHQLLVYSDSNIKTFHIVLKNDIIKPEYIRIYQGNLILTGRLDRNEEIGSIFLQCSMCGKILRQSELYIWPNTPDLPMMMGFDINEKEEKYYLCMPNSGSVRIYSTNFIESHQYYEFDENRPEYIAFSSTQNQLWISCPRNRRILILDLDSGIFRLFNTEQINKAIPKMIFVTDDEKIIFLDITGNRFIWIKRRNEYILTQKLN 469

The following BLAST results are available for this feature:

BLAST of RING-type domain-containing protein vs. Ensembl Human
BLAST of RING-type domain-containing protein vs. Ensembl Celegans
BLAST of RING-type domain-containing protein vs. Ensembl Fly
BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
BLAST of RING-type domain-containing protein vs. Ensembl Mouse
BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
BLAST of RING-type domain-containing protein vs. TrEMBL
BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
BLAST of RING-type domain-containing protein vs. Ensembl Yeast
BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
BLAST of RING-type domain-containing protein vs. Ensembl Medaka
BLAST of RING-type domain-containing protein vs. Planmine SMEST

BLAST of RING-type domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TRIM59	3.217e-7	35.63	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	3.539e-7	35.63	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM59	5.176e-7	33.04	tripartite motif containing 59 [Source:HGNC Symbol...	[more]
TRIM13	9.925e-7	39.02	tripartite motif containing 13 [Source:HGNC Symbol...	[more]
TRIM13	1.021e-6	39.02	tripartite motif containing 13 [Source:HGNC Symbol...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
nhl-1	1.452e-9	36.08	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]
nhl-1	1.490e-9	36.08	RING finger protein nhl-1 [Source:UniProtKB/Swiss...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
trim2a	5.079e-6	35.87	tripartite motif containing 2a [Source:ZFIN;Acc:ZD...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSXETT00000026455.1	1.853e-8	38.55	tripartite motif containing 59 [Source:NCBI gene;A...	[more]
sim2	9.520e-7	36.59	SIM bHLH transcription factor 2 [Source:Xenbase;Ac...	[more]
TRIM50	2.285e-6	44.07	tripartite motif containing 50 [Source:NCBI gene;A...	[more]
TRIM50	4.406e-6	44.83	tripartite motif containing 50 [Source:NCBI gene;A...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Trim50	9.294e-7	42.11	tripartite motif-containing 50 [Source:MGI Symbol;...	[more]
Trim50	9.863e-7	42.11	tripartite motif-containing 50 [Source:MGI Symbol;...	[more]
Trim13	1.206e-6	37.80	tripartite motif-containing 13 [Source:MGI Symbol;...	[more]
Trim13	1.206e-6	37.80	tripartite motif-containing 13 [Source:MGI Symbol;...	[more]
Trim59	3.760e-6	34.48	tripartite motif-containing 59 [Source:MGI Symbol;...	[more]

BLAST of RING-type domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q03601\|NHL1_CAEEL	1.896e-8	36.08	RING finger protein nhl-1 OS=Caenorhabditis elegan...	[more]
sp\|O60858\|TRI13_HUMAN	4.901e-6	39.02	E3 ubiquitin-protein ligase TRIM13 OS=Homo sapiens...	[more]
sp\|F6ZQ54\|TRI13_XENTR	5.044e-6	36.59	Tripartite motif containing 13 OS=Xenopus tropical...	[more]
sp\|Q810I2\|TRI50_MOUSE	6.899e-6	42.11	E3 ubiquitin-protein ligase TRIM50 OS=Mus musculus...	[more]
sp\|Q9CYB0\|TRI13_MOUSE	8.434e-6	37.80	E3 ubiquitin-protein ligase TRIM13 OS=Mus musculus...	[more]

BLAST of RING-type domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267ECL9	2.638e-39	24.59	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267DTD7	7.647e-39	24.59	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267FRC4	9.100e-39	24.27	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A1I8IQ65	1.069e-38	25.42	RING-type domain-containing protein OS=Macrostomum...	[more]
A0A267FKZ3	1.860e-19	33.33	RING-type domain-containing protein OS=Macrostomum...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSAMXT00000043988.1	3.814e-6	34.72	RING finger protein 223-like [Source:NCBI gene;Acc...	[more]
TRIM50	7.715e-6	42.11	tripartite motif containing 50 [Source:NCBI gene;A...	[more]
TRIM50	7.715e-6	42.11	tripartite motif containing 50 [Source:NCBI gene;A...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000010730.1	1.670e-7	37.84	pep scaffold:Pmarinus_7.0:GL485872:9458:10706:1 ge...	[more]
trim59	1.088e-6	31.91	tripartite motif containing 59 [Source:ZFIN;Acc:ZD...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of RING-type domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO41454	8.009e-8	37.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33043	2.606e-7	38.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34308	4.466e-7	30.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30256	7.676e-7	35.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33238	1.721e-6	36.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of RING-type domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSORLT00000015094.2	2.739e-7	46.15	pep primary_assembly:ASM223467v1:17:17654645:17656...	[more]
ENSORLT00000019661.2	5.654e-7	36.92	pep primary_assembly:ASM223467v1:13:32568675:32574...	[more]

BLAST of RING-type domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000064098.1	0.000e+0	100.00	SMESG000064098.1	[more]
SMESG000064098.1	0.000e+0	100.00	SMESG000064098.1	[more]
SMESG000020467.1	2.144e-61	29.94	SMESG000020467.1	[more]
SMESG000081132.1	9.441e-41	28.98	SMESG000081132.1	[more]
SMESG000069646.1	6.172e-28	23.26	SMESG000069646.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022156 ID=SMED30022156|Name=RING-type domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1806bp
CACGAATATATGGTTAAATGGTTTTAGACCAATTAGACATTTCAGTATGA
GCACCACACAACGCACGTGATAAATCATTTGATGCTAAAAAAGTTGATAA
TTTCGAATATGAATGTGCTGAGAACAACTTCGGCTGACGATACAATCAAA
GGAGCTTCAGAAAGGCAAAGAAATAAATCAGAATCATGCGTTTGTTCGAA
GGTTTTCCATAAATCAAATAATGAGTTTTCGAGCATTGAGAACCTTGAAG
ATCTCCTAACATGCCCGATACATTTGGGAGCAATAGATGAGCCTAGGCAA
TTGCAATGTGGACATGTGTTCTGTTTATCGTGTTTAGAGAGCTATGCCAG
CCATGGATTGGAAACAAGTCCTAAACAAATATGCTGTCCATTATGCAGAA
ACCATACACAACTTGATCATAAAGGAATAAAAAGTCTCGCTCCTTCGTTT
CTACACAAACAACTCACGGAATATTTGTTCAACAAAAAACAAAAGGTTTT
GAACATGTCAGCAGAATTCGATGAGCTCCATGTCACTTCTAGTAATAATA
TTTTTAAAACCAAATTGCAACTCATGAATCAGTTGTTGAATGATATCAAA
ACCAAAGACCTTTCTTTAGATGTCTTATCTCCGGAATCGAATGAAAATTT
TATTCAAAATCTCACAGAAGTCTTAGAAAAACATAACATTCCCAAAAAAC
CAACGAATTCACGAGTTCGATCAAAAAGTGTTTTGGTGACAAATTCCAGT
GAATTCGGTATGAGCTACTGCGACCTGAAATTTAAATCCTTTGACGAGAC
GACTATTCGAAAGAATATGAGAAAATATCGAGAATACACTCTTGAAAAAT
ACTTTCTCAACCACATCGACACTTCCGTTATTGGAATAACCTCTATTCAT
CAAACGAATATCCTTGACATTTCTGACGACAAAATTTCTCTCATTTACAT
TATCAAAGACAGTCCGGAAATTTGTCTAGCAAATTCTCGCGGGTTGAAAT
TACGCTCGTTTTTTATAAGCGTAGAAAATTCGAAAATATTCCCGATTTTT
ATCAAATGTTTTCTGAATAAAATCTTTGTCAGCGGGAAAATCGGATTAGA
CCAATCATCGTGTCTTATTCAGTTGTCATTGAATGGTGAGAGGGAGAATA
TTTCACCGATTTATTCCGGACTTTTCGGGGGATTTTGTTTTGATTTGACA
AATAATTCGATTTTCGTTGCTTATCCATCGAGGAATCAAGTTATTCTTCT
TGATAATTCTCTTGAAAAAGAATTGAAGGTTTTTGAATTTGGTAATTTGT
CTCCCATGTTCGTAGCGATCTCGTTTAAGACTCGAGAGATTTGGGTTTCA
TGTCCCAATGACGGCCGAATAGCGGTTTATGATGAAATGACAGATAATTA
CTTGCATTTAGCTACAAATCAAATCTACGAGTCGACCCCAACTCATATTA
TTGAAACTTTGGATCATCGTCTGTTGTTTCTCGATGTTGGCAAGAGTCGG
CTGTTTTGGATATTCCGATGGAACAGTTGTTTGTATATTCAATTGATAAA
TGTCAACGGCTCAAAGGAGGAAATCAAAATTAACACCGTTCAATCTATTT
CCGAGAATATGATCTTATTTTCCGACGGAAATAAAACATTTATTGCTAGA
CCTAACAGATCACCGAAAGAAGAGCATCAAAAACTTAAATGTAGAATTTT
GTAATAGCGTTTTTGTTTTTTAAATGATTTGTAAAGTTTACTGAATTTTT
CAAGATGGCTTTTTTTTTTCTCCATTTAATATTGTATATTTATAATGATG
TTGGGG

protein sequence of SMED30022156-orf-1

>SMED30022156-orf-1 ID=SMED30022156-orf-1|Name=SMED30022156-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=541bp
MLKKLIISNMNVLRTTSADDTIKGASERQRNKSESCVCSKVFHKSNNEFS
SIENLEDLLTCPIHLGAIDEPRQLQCGHVFCLSCLESYASHGLETSPKQI
CCPLCRNHTQLDHKGIKSLAPSFLHKQLTEYLFNKKQKVLNMSAEFDELH
VTSSNNIFKTKLQLMNQLLNDIKTKDLSLDVLSPESNENFIQNLTEVLEK
HNIPKKPTNSRVRSKSVLVTNSSEFGMSYCDLKFKSFDETTIRKNMRKYR
EYTLEKYFLNHIDTSVIGITSIHQTNILDISDDKISLIYIIKDSPEICLA
NSRGLKLRSFFISVENSKIFPIFIKCFLNKIFVSGKIGLDQSSCLIQLSL
NGERENISPIYSGLFGGFCFDLTNNSIFVAYPSRNQVILLDNSLEKELKV
FEFGNLSPMFVAISFKTREIWVSCPNDGRIAVYDEMTDNYLHLATNQIYE
STPTHIIETLDHRLLFLDVGKSRLFWIFRWNSCLYIQLINVNGSKEEIKI
NTVQSISENMILFSDGNKTFIARPNRSPKEEHQKLKCRIL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002075	pigment cell
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001841	Znf_RING
IPR013083	Znf_RING/FYVE/PHD
IPR018957	Znf_C3HC4_RING-type
IPR011042	6-blade_b-propeller_TolB-like
IPR017907	Znf_RING_CS

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0030218	erythrocyte differentiation
GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001841	Zinc finger, RING-type	SMART	SM00184	ring_2	coord: 61..105 e-value: 7.6E-4 score: 28.8
IPR001841	Zinc finger, RING-type	PROSITE	PS50089	ZF_RING_2	coord: 61..106 score: 10.807
IPR018957	Zinc finger, C3HC4 RING-type	PFAM	PF00097	zf-C3HC4	coord: 61..105 e-value: 1.8E-4 score: 21.3
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 39..152 e-value: 8.1E-15 score: 56.4
None	No IPR available	PANTHER	PTHR25464	FAMILY NOT NAMED	coord: 55..187
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 56..135
None	No IPR available	SUPERFAMILY	SSF63825	YWTD domain	coord: 362..518
IPR017907	Zinc finger, RING-type, conserved site	PROSITE	PS00518	ZF_RING_1	coord: 76..85

Main menu

RING-type domain-containing protein

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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