NPHP4

Overview


Name	NPHP4 (AKN21706.1)
Smed ID	SMED30022153
Length (bp)	4448

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of NPHP4 (SMED30022153) t-SNE clustered cells

Violin plots show distribution of expression levels for NPHP4 (SMED30022153) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NPHP4 (SMED30022153) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NPHP4 (SMED30022153) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30022153

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30022153	SMESG000062716.1	SmedASXL_017817	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30022153	SMESG000062716.1	dd_Smed_v4_12520_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30022153	SMESG000062716.1	dd_Smed_v4_12520_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30022153	SMESG000062716.1	dd_Smed_v6_12520_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
epidermis	SMED30022153	SMESG000062716.1	dd_Smed_v4_12520_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of NPHP4 vs. Ensembl Human
Match: NPHP4 (nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104])

HSP 1 Score: 455.677 bits (1171), Expect = 1.746e-135
Identity = 289/886 (32.62%), Postives = 458/886 (51.69%), Query Frame = 1

Query: 1861 QMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN------------------SSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSE-AKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNM-ALQADQSFASPAMSSP----VRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            Q RS  G   SRA    + ++GF EILD N +    +  +  +    N + EE D  Q NE++ QF+A +R   D  G S P K+V+FTFQFYRFP  +T RL L  + +       A   IL      G      PG  ++YM+ P F+KPGE   F  YL  QTL +DVWDGDSLLLIGS AV++++L RQG+ +VQ+S EL++++  + + +N                   S + GRLH+ +AN+G    +K  G + +  P +  +I    AS+  G                 +  T      H      VV+ Q     + EL+ ++ T +           KGP   +D+ R ++    +KL+R ++   +L+    ++  +  S  A++S + +    LQ I  YRE+ K E I   L+  I  E  ++   G  E FE  +KN  N    V++EI++    V I ++QE R  K    + T  E D+ +        Q+++R  E+  +PFK+ +  A Q     ASP +S+       +P K ++V  ++ +++FR +  K +++L + V  QP ++DQ FRF+HPE SFL++ IR+PP H      +    E   +  RC+D +V+ E      G P DI LKV  GPSP+++ F + +Y D++L  P Q W   +HS  R+DV    GQ T ++L+L+G      V+ FTSHP+E+   P     F L      +L + + P++ G+R  H+N+VD++ H L+ SW++C  C++P ISK FE+ L  G G+   KRI + NPYP ++ F+L +D P+L+  ++    +   +   IG+ F P  +   ++I ++IND + KNEE F + V YQ
Sbjct:  585 QTRSSAGQP-SRASMVLLQSSGFPEILDANKQPAEAV--SATEPVTFNPQKEESDCLQSNEMVLQFLAFSRVAQDCRGTSWP-KTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQLRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMKHLLRQGRPAVQASHELEVVA-TEYEQDNMVVSGDMLGFGRVKPIGVHSVVKGRLHLTLANVGHPCEQKVRGCSTLP-PSRSRVISNDGASRFSG---------------GSLLTTGSSRRKH------VVQAQKLADVDSELAAMLLTHARQG--------KGP---QDVSRESDATRRRKLERMRSV--RLQEAGGDLGRRGTSVLAQQSVRTQHLRDLQVIAAYRERTKAESIASLLSLAITTEHTLHATLGVAEFFEFVLKNPHNTQHTVTVEIDNPELSV-IVDSQEWRDFKGAAGLHTPVEEDMFHLRGSL-APQLYLRPHETAHVPFKFQSFSAGQLAMVQASPGLSNEKGMDAVSPWKSSAVPTKHAKVLFRASGGKPIAVLCLTVELQPHVVDQVFRFYHPELSFLKKAIRLPPWHTFPGAPVGMLGEDPPVHVRCSDPNVICETQNVGPGEPRDIFLKVASGPSPEIKDFFVIIYSDRWLATPTQTWQVYLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDP--KGVFVLPPRGVQDLHVGVRPLRAGSRFVHLNLVDVDCHQLVASWLVCLCCRQPLISKAFEIMLAAGEGKGVNKRITYTNPYPSRRTFHLHSDHPELLRFREDSFQVGGGETYTIGLQFAPSQRVGEEEILIYINDHEDKNEEAFCVKVIYQ 1426

HSP 2 Score: 103.605 bits (257), Expect = 2.424e-21
Identity = 119/451 (26.39%), Postives = 193/451 (42.79%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRY-KTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL-EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGR-KDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF 1338
            +PP  +R      ++ +F C+ K LD  +  + V +    +  +++ S FD  Y+ FFG+ W ++          I     N+P+YF+T+    ++  + E++   K  D       C F +L+       + SN+    IS      + +Y GT RAL    L+   E +  +   EN  L  ++  H A +    L+PE  LV     I GL     E       PRL K     ++ +   + PSL +FE+ELLE    D  +        D  +L I+ERRLRVGVHNG+ +++    + L    +V   +    S +  SS         L  ++ + +  M     F ++F LEY  + P   DG    +  +S L    + VRW V+ P  +       D  R+ L   GG    P + LVYK  S       ++++E G   F
Sbjct:   14 VPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRVSFFDVTYRHFFGRTWKTTVKPTKRPPSRIV---FNEPLYFHTSLNHPHIVAVVEVVAEGKKRDGSLQTLSCGFGILR-------IFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLIENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGLLPAHGESGDALRKPRLQKPITGHLDDLFFTLYPSLEKFEEELLELHVQDHFQEGCGPL--DGGALEILERRLRVGVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKVVSSSKTSSGSQALVLRSRLRLPEMVGHPAFAVIFQLEYVFSSPAGVDGNAASVTSLSNL-ACMHMVRWAVWNPLLEA------DSGRVTLPLQGGIQPNPSHCLVYKVPSASMSSEEVKQVESGTLRF 445

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BLAST of NPHP4 vs. Ensembl Human
Match: NPHP4 (nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104])

HSP 1 Score: 160.614 bits (405), Expect = 3.505e-39
Identity = 104/282 (36.88%), Postives = 150/282 (53.19%), Query Frame = 1

Query: 1861 QMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN------------------SSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEG 2637
            Q RS  G   SRA    + ++GF EILD N +    +  +  +    N + EE D  Q NE++ QF+A +R   D  G S P K+V+FTFQFYRFP  +T RL L  + +       A   IL      G      PG  ++YM+ P F+KPGE   F  YL  QTL +DVWDGDSLLLIGS AV++++L RQG+ +VQ+S EL++++  + + +N                   S + GRLH+ +AN+G    +K  G + +  P +  +I    AS+  G
Sbjct:  584 QTRSSAGQP-SRASMVLLQSSGFPEILDANKQPAEAV--SATEPVTFNPQKEESDCLQSNEMVLQFLAFSRVAQDCRGTSWP-KTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQLRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMKHLLRQGRPAVQASHELEVVA-TEYEQDNMVVSGDMLGFGRVKPIGVHSVVKGRLHLTLANVGHPCEQKVRGCSTLP-PSRSRVISNDGASRFSG 859

HSP 2 Score: 104.375 bits (259), Expect = 8.171e-22
Identity = 119/451 (26.39%), Postives = 193/451 (42.79%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRY-KTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL-EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEIS-MPNDQEFTIVFILEYSIAEPVYSDG-RKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF 1338
            +PP  +R      ++ +F C+ K LD  +  + V +    +  +++ S FD  Y+ FFG+ W ++          I     N+P+YF+T+    ++  + E++   K  D       C F +L+       + SN+    IS      + +Y GT RAL    L+   E +  +   EN  L  ++  H A +    L+PE  LV     I GL     E       PRL K     ++ +   + PSL +FE+ELLE    D  +        D  +L I+ERRLRVGVHNG+ +++    + L    +V   +    S +  SS         L  ++ + +  M     F ++F LEY  + P   DG    +  +S L    + VRW V+ P  +       D  R+ L   GG    P + LVYK  S       ++++E G   F
Sbjct:   14 VPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRVSFFDVTYRHFFGRTWKTTVKPTKRPPSRIVF---NEPLYFHTSLNHPHIVAVVEVVAEGKKRDGSLQTLSCGFGILR-------IFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLIENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGLLPAHGESGDALRKPRLQKPITGHLDDLFFTLYPSLEKFEEELLELHVQDHFQEGCGPL--DGGALEILERRLRVGVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKVVSSSKTSSGSQALVLRSRLRLPEMVGHPAFAVIFQLEYVFSSPAGVDGNAASVTSLSNL-ACMHMVRWAVWNPLLEA------DSGRVTLPLQGGIQPNPSHCLVYKVPSASMSSEEVKQVESGTLRF 445

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Query: 1861 QMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN------------------SSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEG 2637
            Q RS  G   SRA    + ++GF EILD N +    +  +  +    N + EE D  Q NE++ QF+A +R   D  G S P K+V+FTFQFYRFP  +T RL L  + +       A   IL      G      PG  ++YM+ P F+KPGE   F  YL  QTL +DVWDGDSLLLIGS AV++++L RQG+ +VQ+S EL++++  + + +N                   S + GRLH+ +AN+G    +K  G + +  P +  +I    AS+  G
Sbjct:  584 QTRSSAGQP-SRASMVLLQSSGFPEILDANKQPAEAV--SATEPVTFNPQKEESDCLQSNEMVLQFLAFSRVAQDCRGTSWP-KTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQLRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMKHLLRQGRPAVQASHELEVVA-TEYEQDNMVVSGDMLGFGRVKPIGVHSVVKGRLHLTLANVGHPCEQKVRGCSTLP-PSRSRVISNDGASRFSG 859

HSP 2 Score: 104.375 bits (259), Expect = 8.171e-22
Identity = 119/451 (26.39%), Postives = 193/451 (42.79%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRY-KTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL-EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEIS-MPNDQEFTIVFILEYSIAEPVYSDG-RKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF 1338
            +PP  +R      ++ +F C+ K LD  +  + V +    +  +++ S FD  Y+ FFG+ W ++          I     N+P+YF+T+    ++  + E++   K  D       C F +L+       + SN+    IS      + +Y GT RAL    L+   E +  +   EN  L  ++  H A +    L+PE  LV     I GL     E       PRL K     ++ +   + PSL +FE+ELLE    D  +        D  +L I+ERRLRVGVHNG+ +++    + L    +V   +    S +  SS         L  ++ + +  M     F ++F LEY  + P   DG    +  +S L    + VRW V+ P  +       D  R+ L   GG    P + LVYK  S       ++++E G   F
Sbjct:   14 VPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRVSFFDVTYRHFFGRTWKTTVKPTKRPPSRIVF---NEPLYFHTSLNHPHIVAVVEVVAEGKKRDGSLQTLSCGFGILR-------IFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLIENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGLLPAHGESGDALRKPRLQKPITGHLDDLFFTLYPSLEKFEEELLELHVQDHFQEGCGPL--DGGALEILERRLRVGVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKVVSSSKTSSGSQALVLRSRLRLPEMVGHPAFAVIFQLEYVFSSPAGVDGNAASVTSLSNL-ACMHMVRWAVWNPLLEA------DSGRVTLPLQGGIQPNPSHCLVYKVPSASMSSEEVKQVESGTLRF 445

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BLAST of NPHP4 vs. Ensembl Human
Match: NPHP4 (nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104])

HSP 1 Score: 111.694 bits (278), Expect = 6.788e-28
Identity = 59/128 (46.09%), Postives = 76/128 (59.38%), Query Frame = 1

Query: 2041 EIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLR 2418
            E++ QF+A +R   D  G S P K+V+FTFQFYRFP  +T RL L  + +       A   IL      G      PG  ++YM+ P F+KPGE   F  YL  QTL +DVWDGDSLLLIGS AV+++
Sbjct:    2 EMVLQFLAFSRVAQDCRGTSWP-KTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQLRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMK 128

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BLAST of NPHP4 vs. Ensembl Human
Match: NPHP4 (nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104])

HSP 1 Score: 56.225 bits (134), Expect = 1.531e-7
Identity = 51/213 (23.94%), Postives = 92/213 (43.19%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL 666
            +PP  +R      ++ +F C+ K LD  +  + V +    +  +++ S FD  Y+ FFG+ W ++          I     N+P+YF+T+    ++  + E++    + + +         L C   +  + SN+    IS      + +Y GT RAL    L+   E +  +   EN  L  ++  H A +    L+PE  LV     I GL
Sbjct:   14 VPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRVSFFDVTYRHFFGRTWKTTVKPTKRPPSRIVF---NEPLYFHTSLNHPHIVAVVEVVAEGKKRDGS------LQTLSCGFGILRIFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLIENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGL 217

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BLAST of NPHP4 vs. Ensembl Celegans
Match: nphp-4 (NePHronoPhthisis (Human kidney disease) homolog; Nephrocystin-4-like protein [Source:UniProtKB/TrEMBL;Acc:G5ECP0])

HSP 1 Score: 100.138 bits (248), Expect = 9.300e-21
Identity = 66/232 (28.45%), Postives = 118/232 (50.86%), Query Frame = 1

Query: 1882 LGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLP-PGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYN 2574
            +   R+ +S      F ++ D NG  P   D       +++ + E+ D    + + FQF+A  +     ++R  K +FFT  FYRFP I+T+ ++L       ++ EK  P +L + + +G   V+  PG + KY+++    K      F++++      +DVWD DSL+ +GS  V ++NL R+G+ +VQ   +  +   VD   + SSK    L++R+AN+G      Y+
Sbjct:  540 INFPRSAHSMFARQNFTQLKDRNGSPPNTEDVTLK--TIIDMKREQLDRLITSHVYFQFIAFKQL-AAPDARMIKKLFFTIGFYRFPDITTESMLL-------TSMEKGEPTLLTRLDKNGNSDVIASPGFIAKYIIEGEESKA----DFLDFMASGHATIDVWDSDSLIHLGSTIVPIKNLYRRGREAVQLFIQCPV---VDTSLDTSSKAGAFLYMRVANIGFPSGNTYD 754

HSP 2 Score: 94.3597 bits (233), Expect = 5.740e-19
Identity = 92/400 (23.00%), Postives = 176/400 (44.00%), Query Frame = 1

Query: 3097 IYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDK-LLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILS-RCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSF----SLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTI 4278
            I P FG    FE  ++N+ +   N +IE +D   L P+ + +E +  K++  +TT SE  ++    ++   +I ++  + + IPF Y       D                  A      ++VFR  + K  L+IL + V  +  ++  +  F         + + +PP+          ++LS RC+D  V     ++       +      G +   + FLL +Y D +  + +  W  T+     +DV +  GQ+T + LL+   S    V      P+++L     +       S+    T   +++ TP  IG +K  V+VV+  +  L R +++    + P I++ F +Q+P    +  +KRI  +NPY   K F ++T   D+V + D++L++
Sbjct:  893 INPSFGEKVFFEFPLENYNSEPINCTIEFDDEA-LKPVFDAEEWKFYKTVNKVTTPSEKQMMRQTTDR--IEICLQPGDVLFIPFIYDAFFFPND------------------AFNMYSTKVVFRRWDTKEPLAILDLHVHRRNFLLQHSVTFICETSGNWEKQLVLPPMA------RDRRVLSCRCSDPSV--RLTVRNATLQQIVGFTTYSGETNDRKTFLLLMYSDHYQTRLMATWKITILPFFNVDVRSIVGQTTRLHLLVHRRSEHDGV------PDDLLKVYTASGCMKVVDSVLTERTPTATIDFTPNFIGTKKLVVSVVNTNTLKLERGFLVYGKSEAPRITQKFVIQIP-SSDEAIRKRIPIRNPYGLPKTFRITTSNSDIVKITDSLLSV 1256

HSP 3 Score: 81.2629 bits (199), Expect = 4.697e-15
Identity = 99/428 (23.13%), Postives = 177/428 (41.36%), Query Frame = 1

Query:   73 PKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIY--IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTED--NQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPN---DQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK-----PDSV 1305
            P E + N      + C  +   +L+S   P   ENI   I A LFD      FG+Q  +  +   +    +F    N+ +YFY+      + +I E +   +++    T +GW   ++ K T V       + S T    ++ GT + L       + +  +K   N  +  + NI +   +    +PE+ +V + DII G+  D+        P+       +I+ + +  + ++ E EK++  +I  +   ++G +    A    I++R+LR+GVHNG  Y+ +  T+ L     N  D    R         S  EE     A  +  +++ N   D    I+F+LEY+         R+D   ++     T  + W  + PF+  +       +   + F GG    PE  L YK     PDS+
Sbjct:   15 PVEMKRNVSRGTKALCYSMFISNLTS---PQLTENIRYQISAFLFDTKTSQMFGRQCRTEWIPANSNGTCVF----NETLYFYSIINSRDVLLILEFVEEGSDEITPATSVGWFSTHIEKKTPV-------EISNTKIFDIFGGTPKLLIF-----DKETVLKPVGN--VECTYNIFEMPPIFFQCLPEFCIVCDKDIIPGIIKDSSDEWWLSTPKEMPTIPAAIDAIVIQFKNNVPELEKQITHDIEKEWALKEGGTLKPKAI---IMDRKLRIGVHNGYTYVTEPFTVDLEIISSNAGDTLRSRKKPIDFGKSSNWEEQLLFQAAGNPRLALRNLYADPRMAIIFLLEYTFH-------REDNQSLN----QTILIGWAAWTPFS--DGAFSGKEVETRVSFVGGPRPNPEGVLCYKNVLNQPDSL 405

[Close]

BLAST of NPHP4 vs. Ensembl Zebrafish
Match: nphp4 (nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-060503-715])

HSP 1 Score: 430.254 bits (1105), Expect = 7.714e-127
Identity = 287/867 (33.10%), Postives = 448/867 (51.67%), Query Frame = 1

Query: 1906 SQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNF--ELEERDHKQCNEIIFQFMALTRFDVNG-NSRPTKSVFFTFQFYRFPVISTDRL-ILDNIIDQISNYEKAT--PMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN-----------SSKLS------GRLHIRMANLG-SVPSKKYN-----GLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIV-VRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENEN-INDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +Q+++AGF +ILD   +   V+DP++     VNF  + EE D  Q N +I QF+A TR   +G NS    SV FTFQ YRFP ++T RL +LD   ++ S ++ ++  P +L      G  S   PG  ++Y +DP F+KPGE   F+ YL   +L +DVWD DSL+LIGS AV+L+++ RQG+ +VQ S EL++I+   + D +           +S +S      G LH+R+ N+G SV + + +       + +  P  G        EG                   R   +T   L  SN    R  P I  N EL+ L+++        SM  V G    E  +R       +K+ R     +  E ++E    D     + R+D+V+    L+ I+ YRE+ K + I   L+  I  +  +Y   G  E FE  +KN FN+   V+IE +D    V +  ++E R  K +    T  E ++ +   +    Q+++R KESV +PFKY        Q+F     S P+             Q++FR  + K L+I +V V P P ++DQTFRF+ PE +FL++ IR+P      +   A  +   C+D +V+        G P D+ LKVP  PSPQ+R+F + ++ D +L  P Q+W   VH   R+D+    G  +  +LLL+G      V+ +TSHP E+ V P E   F+L A    ++ + L  ++ G+R F++NVVD+++  L+ SW++C TC++P ISK FE+ +P+ GG+   K+I F NPY   + F L TDRPDL+  K+    I   ++  IG+ F P      ++I +FIND+  KNE+T+ + V Y+
Sbjct:  595 AQLFSAGFPQILDHQNQVAEVLDPSEP----VNFNPQREEADSLQTNTLILQFLAFTRVPQSGVNSDWPSSVHFTFQLYRFPPVTTQRLKLLDQ--EKTSKFKGSSDSPCVLSLLNKDGTLSSGFPGLQLQYRVDPQFLKPGERGWFLRYLALHSLQIDVWDSDSLMLIGSAAVELKHMLRQGRPAVQVSHELEVITTEYMQDASFTSRHDSKHSATSAISVYTTVKGILHLRLGNIGGSVWNTQSSPAVPPSFSHVLQPNDG---PQGLAEG-------------------RVSALTLLQLNASNARRARRLPEI--NSELARLLQS--------SMREVGG--AEEKEVR------QRKIDRMAAVRQHEEQKDEPPFQDYTNVTSHRADRVQHLRDLRVIEAYRERCKTQEITNMLSQAITTKHTLYATLGTAEFFEFVLKNPFNVPQTVTIECDDPELSV-LVKSEEWRYFKELTKTLTPLEEEMFHLKEKTLTPQVYLRPKESVHVPFKY--------QTFVC-GHSFPL-------------QVLFRGEDRKPLAICQVDVEPTPHVVDQTFRFYQPELTFLKKAIRLPAAWDDTADGSA-SLHVHCSDPNVICHTTSLTPGEPQDVYLKVPGSPSPQIRKFFITIFTDPWLASPAQIWQVYVHYLQRMDLSCVCGALSWHSLLLRGTQAIRRVKCYTSHPLELQVDPAE--VFALPAQGVQDVRVGLRALRAGSRFFYLNVVDVDTRQLVDSWLLCITCRQPVISKAFEISVPVEGGKGSNKKISFTNPYSSSRVFNLRTDRPDLLHFKEEQFQIGGGELYTIGLRFAPSQNPGMEEILIFINDKQDKNEDTYCVRVQYR 1389

HSP 2 Score: 111.309 bits (277), Expect = 5.950e-24
Identity = 104/433 (24.02%), Postives = 191/433 (44.11%), Query Frame = 1

Query:   31 DLRVLSEKHKYIPPPKE--RQGNTKADNLSFCIKLLD-LDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKT--EDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL--EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL--NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ--VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            + R   ++++ IPP  +  RQ    A  L    K LD L ++    P + +   ++ +LFD  +Q FFG+ W S +          + +  N+ +YF+T+     +  + E++   T  +  Q  +G   F LL+      +   ++  + +++  + GT RAL    LK   + +  +   E + L  SI  H A      L+P   LV   + I G+    D +       PRL K  +  +E ++V + PS+  FE +LL+ +N D    +  +   +  S+ + ERRL VGVHNG  ++E    + L  +    +  +         S  +  + L+ +  +++ +  D +F+IVF L+Y  + P+  DG+      + +P+  +   VRW  +  F          G  + L+  G S   P   +VY
Sbjct:    3 EWRSAFQRNRVIPPHSQTARQAPGSAQGLQLLFKHLDGLHVTQSESPPSLQ-YQLRVTLFDSGHQHFFGRTWKSGSHSVSGSPGQSYRVLFNEVVYFHTSLCLSSVMAVVELVSLSTRADGTQEAVG-SGFGLLQLFTGHAESSVSQGEDRLNL--FHGTPRALLHPTLKDPLQLNAMLSVMEGTQLIYSIQPHLALTTIMHLLPPNVLVSGHEKIPGVVSPTDTDTADALRKPRLLKSFSCVLEGLRVTLFPSVEVFESDLLQLLNRDCQNTNRGA---EGRSVVVQERRLLVGVHNGWGWVEKPQVLVLERDSGGTEAAKARGSSFRQTSTDKLSDGLSLRGGVQLKLMRDVDFSIVFQLQYVFSCPLAVDGQL---TSTAVPRAAFMQCVRWCAWSLFWDPEG----PGENVCLNLQGDSFPNPWAVMVY 421

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BLAST of NPHP4 vs. Ensembl Zebrafish
Match: nphp4 (nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-060503-715])

HSP 1 Score: 429.869 bits (1104), Expect = 8.549e-127
Identity = 287/867 (33.10%), Postives = 448/867 (51.67%), Query Frame = 1

Query: 1906 SQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNF--ELEERDHKQCNEIIFQFMALTRFDVNG-NSRPTKSVFFTFQFYRFPVISTDRL-ILDNIIDQISNYEKAT--PMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN-----------SSKLS------GRLHIRMANLG-SVPSKKYN-----GLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIV-VRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENEN-INDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +Q+++AGF +ILD   +   V+DP++     VNF  + EE D  Q N +I QF+A TR   +G NS    SV FTFQ YRFP ++T RL +LD   ++ S ++ ++  P +L      G  S   PG  ++Y +DP F+KPGE   F+ YL   +L +DVWD DSL+LIGS AV+L+++ RQG+ +VQ S EL++I+   + D +           +S +S      G LH+R+ N+G SV + + +       + +  P  G        EG                   R   +T   L  SN    R  P I  N EL+ L+++        SM  V G    E  +R       +K+ R     +  E ++E    D     + R+D+V+    L+ I+ YRE+ K + I   L+  I  +  +Y   G  E FE  +KN FN+   V+IE +D    V +  ++E R  K +    T  E ++ +   +    Q+++R KESV +PFKY        Q+F     S P+             Q++FR  + K L+I +V V P P ++DQTFRF+ PE +FL++ IR+P      +   A  +   C+D +V+        G P D+ LKVP  PSPQ+R+F + ++ D +L  P Q+W   VH   R+D+    G  +  +LLL+G      V+ +TSHP E+ V P E   F+L A    ++ + L  ++ G+R F++NVVD+++  L+ SW++C TC++P ISK FE+ +P+ GG+   K+I F NPY   + F L TDRPDL+  K+    I   ++  IG+ F P      ++I +FIND+  KNE+T+ + V Y+
Sbjct:  594 AQLFSAGFPQILDHQNQVAEVLDPSEP----VNFNPQREEADSLQTNTLILQFLAFTRVPQSGVNSDWPSSVHFTFQLYRFPPVTTQRLKLLDQ--EKTSKFKGSSDSPCVLSLLNKDGTLSSGFPGLQLQYRVDPQFLKPGERGWFLRYLALHSLQIDVWDSDSLMLIGSAAVELKHMLRQGRPAVQVSHELEVITTEYMQDASFTSRHDSKHSATSAISVYTTVKGILHLRLGNIGGSVWNTQSSPAVPPSFSHVLQPNDG---PQGLAEG-------------------RVSALTLLQLNASNARRARRLPEI--NSELARLLQS--------SMREVGG--AEEKEVR------QRKIDRMAAVRQHEEQKDEPPFQDYTNVTSHRADRVQHLRDLRVIEAYRERCKTQEITNMLSQAITTKHTLYATLGTAEFFEFVLKNPFNVPQTVTIECDDPELSV-LVKSEEWRYFKELTKTLTPLEEEMFHLKEKTLTPQVYLRPKESVHVPFKY--------QTFVC-GHSFPL-------------QVLFRGEDRKPLAICQVDVEPTPHVVDQTFRFYQPELTFLKKAIRLPAAWDDTADGSA-SLHVHCSDPNVICHTTSLTPGEPQDVYLKVPGSPSPQIRKFFITIFTDPWLASPAQIWQVYVHYLQRMDLSCVCGALSWHSLLLRGTQAIRRVKCYTSHPLELQVDPAE--VFALPAQGVQDVRVGLRALRAGSRFFYLNVVDVDTRQLVDSWLLCITCRQPVISKAFEISVPVEGGKGSNKKISFTNPYSSSRVFNLRTDRPDLLHFKEEQFQIGGGELYTIGLRFAPSQNPGMEEILIFINDKQDKNEDTYCVRVQYR 1388

HSP 2 Score: 110.923 bits (276), Expect = 8.561e-24
Identity = 104/432 (24.07%), Postives = 191/432 (44.21%), Query Frame = 1

Query:   31 DLRVLSEKHKYIPPPKE--RQGNTKADNLSFCIKLLD-LDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKT--EDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL--NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ--VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            + R   ++++ IPP  +  RQ    A  L    K LD L ++    P + +   ++ +LFD  +Q FFG+ W S +          + +  N+ +YF+T+     +  + E++   T  +  Q  +G   F LL+      +   ++  + +++  + GT RAL    LK   + +  +   E + L  SI  H A      L+P   LV   + I G+    +   D    PRL K  +  +E ++V + PS+  FE +LL+ +N D    +  +   +  S+ + ERRL VGVHNG  ++E    + L  +    +  +         S  +  + L+ +  +++ +  D +F+IVF L+Y  + P+  DG+      + +P+  +   VRW  +  F          G  + L+  G S   P   +VY
Sbjct:    3 EWRSAFQRNRVIPPHSQTARQAPGSAQGLQLLFKHLDGLHVTQSESPPSLQ-YQLRVTLFDSGHQHFFGRTWKSGSHSVSGSPGQSYRVLFNEVVYFHTSLCLSSVMAVVELVSLSTRADGTQEAVG-SGFGLLQLFTGHAESSVSQGEDRLNL--FHGTPRALLHPTLKDPLQLNAMLSVMEGTQLIYSIQPHLALTTIMHLLPPNVLVSGHEKIPGVVSPTDTDTDALRKPRLLKSFSCVLEGLRVTLFPSVEVFESDLLQLLNRDCQNTNRGA---EGRSVVVQERRLLVGVHNGWGWVEKPQVLVLERDSGGTEAAKARGSSFRQTSTDKLSDGLSLRGGVQLKLMRDVDFSIVFQLQYVFSCPLAVDGQL---TSTAVPRAAFMQCVRWCAWSLFWDPEG----PGENVCLNLQGDSFPNPWAVMVY 420

[Close]

BLAST of NPHP4 vs. Ensembl Zebrafish
Match: nphp4 (nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-060503-715])

HSP 1 Score: 429.483 bits (1103), Expect = 2.277e-126
Identity = 289/877 (32.95%), Postives = 454/877 (51.77%), Query Frame = 1

Query: 1906 SQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNF--ELEERDHKQCNEIIFQFMALTRFDVNG-NSRPTKSVFFTFQFYRFPVISTDRL-ILDNIIDQISNYEKAT--PMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN-----------SSKLS------GRLHIRMANLG-SVPSKKYN-----GLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIV-VRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENEN-INDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMA------LQADQSFA---SPAMSSPVRTPHKLASVDLE-YQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +Q+++AGF +ILD   +   V+DP++     VNF  + EE D  Q N +I QF+A TR   +G NS    SV FTFQ YRFP ++T RL +LD   ++ S ++ ++  P +L      G  S   PG  ++Y +DP F+KPGE   F+ YL   +L +DVWD DSL+LIGS AV+L+++ RQG+ +VQ S EL++I+   + D +           +S +S      G LH+R+ N+G SV + + +       + +  P  G        EG                   R   +T   L  SN    R  P I  N EL+ L+++        SM  V G    E  +R       +K+ R     +  E ++E    D     + R+D+V+    L+ I+ YRE+ K + I   L+  I  +  +Y   G  E FE  +KN FN+   V+IE +D    V +  ++E R  K +    T  E ++ +   +    Q+++R KESV +PFKY          LQ  +S     SP M+      H   ++  +  +++FR  + K L+I +V V P P ++DQTFRF+ PE +FL++ IR+P      +   A  +   C+D +V+        G P D+ LKVP  PSPQ+R+F + ++ D +L  P Q+W   VH   R+D+    G  +  +LLL+G      V+ +TSHP E+ V P E   F+L A    ++ + L  ++ G+R F++NVVD+++  L+ SW++C TC++P ISK FE+ +P+ GG+   K+I F NPY   + F L TDRPDL+  K+    I   ++  IG+ F P      ++I +FIND+  KNE+T+ + V Y+
Sbjct:  595 AQLFSAGFPQILDHQNQVAEVLDPSEP----VNFNPQREEADSLQTNTLILQFLAFTRVPQSGVNSDWPSSVHFTFQLYRFPPVTTQRLKLLDQ--EKTSKFKGSSDSPCVLSLLNKDGTLSSGFPGLQLQYRVDPQFLKPGERGWFLRYLALHSLQIDVWDSDSLMLIGSAAVELKHMLRQGRPAVQVSHELEVITTEYMQDASFTSRHDSKHSATSAISVYTTVKGILHLRLGNIGGSVWNTQSSPAVPPSFSHVLQPNDG---PQGLAEG-------------------RVSALTLLQLNASNARRARRLPEI--NSELARLLQS--------SMREVGG--AEEKEVR------QRKIDRMAAVRQHEEQKDEPPFQDYTNVTSHRADRVQHLRDLRVIEAYRERCKTQEITNMLSQAITTKHTLYATLGTAEFFEFVLKNPFNVPQTVTIECDDPELSV-LVKSEEWRYFKELTKTLTPLEEEMFHLKEKTLTPQVYLRPKESVHVPFKYQTFVCGHSFPLQDSKSLKISRSPQMAQK----HLSNTIQAKSIKVLFRGEDRKPLAICQVDVEPTPHVVDQTFRFYQPELTFLKKAIRLPAAWDDTADGSA-SLHVHCSDPNVICHTTSLTPGEPQDVYLKVPGSPSPQIRKFFITIFTDPWLASPAQIWQVYVHYLQRMDLSCVCGALSWHSLLLRGTQAIRRVKCYTSHPLELQVDPAE--VFALPAQGVQDVRVGLRALRAGSRFFYLNVVDVDTRQLVDSWLLCITCRQPVISKAFEISVPVEGGKGSNKKISFTNPYSSSRVFNLRTDRPDLLHFKEEQFQIGGGELYTIGLRFAPSQNPGMEEILIFINDKQDKNEDTYCVRVQYR 1417

HSP 2 Score: 110.923 bits (276), Expect = 7.064e-24
Identity = 104/433 (24.02%), Postives = 191/433 (44.11%), Query Frame = 1

Query:   31 DLRVLSEKHKYIPPPKE--RQGNTKADNLSFCIKLLD-LDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKT--EDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL--EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL--NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ--VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            + R   ++++ IPP  +  RQ    A  L    K LD L ++    P + +   ++ +LFD  +Q FFG+ W S +          + +  N+ +YF+T+     +  + E++   T  +  Q  +G   F LL+      +   ++  + +++  + GT RAL    LK   + +  +   E + L  SI  H A      L+P   LV   + I G+    D +       PRL K  +  +E ++V + PS+  FE +LL+ +N D    +  +   +  S+ + ERRL VGVHNG  ++E    + L  +    +  +         S  +  + L+ +  +++ +  D +F+IVF L+Y  + P+  DG+      + +P+  +   VRW  +  F          G  + L+  G S   P   +VY
Sbjct:    3 EWRSAFQRNRVIPPHSQTARQAPGSAQGLQLLFKHLDGLHVTQSESPPSLQ-YQLRVTLFDSGHQHFFGRTWKSGSHSVSGSPGQSYRVLFNEVVYFHTSLCLSSVMAVVELVSLSTRADGTQEAVG-SGFGLLQLFTGHAESSVSQGEDRLNL--FHGTPRALLHPTLKDPLQLNAMLSVMEGTQLIYSIQPHLALTTIMHLLPPNVLVSGHEKIPGVVSPTDTDTADALRKPRLLKSFSCVLEGLRVTLFPSVEVFESDLLQLLNRDCQNTNRGA---EGRSVVVQERRLLVGVHNGWGWVEKPQVLVLERDSGGTEAAKARGSSFRQTSTDKLSDGLSLRGGVQLKLMRDVDFSIVFQLQYVFSCPLAVDGQL---TSTAVPRAAFMQCVRWCAWSLFWDPEG----PGENVCLNLQGDSFPNPWAVMVY 421

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BLAST of NPHP4 vs. Ensembl Zebrafish
Match: BX005102.1 (pep chromosome:GRCz11:CHR_ALT_CTG8_1_7:21978667:22013654:-1 gene:ENSDARG00000113041.1 transcript:ENSDART00000192970.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX005102.1)

HSP 1 Score: 305.449 bits (781), Expect = 5.613e-91
Identity = 171/482 (35.48%), Postives = 267/482 (55.39%), Query Frame = 1

Query: 2968 SEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            S   R+D+V+    L+ I+ YRE+ K + I   L+  I  +  +Y   G  E FE  +KN FN+   V+IE +D    V +  ++E R  K +    T  E ++ +   +    Q+++R KESV +PF + N       SFASP     +   H L  V L +Q++FR  + K L+I +V V P P ++DQTFRF+ PE +FL++ IR+P      +     K     T+   L +C L   G P D+ LKVP  PSPQ+R+F + ++ D +L  P Q+W   VH   R+D+    G  +  +LLL+G      V+ +TSHP E+ V P E   F+L A    ++ + L  ++ G+R F++NVVD+++  L+ SW++C TC++P ISK FE+ +P+ GG+   K+I F NPY   + F L TDRPDL+  K+    I   ++  IG+ F P      ++I +FIND+  KNE+T+ + V Y+
Sbjct:   29 SSRHRADRVQHLRDLRVIEAYRERCKTQEITNMLSQAITTKHTLYATLGTAEFFEFVLKNPFNVPQTVTIECDDPELSV-LVKSEEWRYFKELTKTLTPLEEEMFHLKEKTLTPQVYLRPKESVHVPFNFVN-------SFASPV---SILAGH-LKLVVLVFQVLFRGEDRKPLAICQVDVEPTPHVVDQTFRFYQPELTFLKKAIRLPAAWDDTAGAAHYKHTHTHTNKHKL-QCLLLTPGEPQDVYLKVPGSPSPQIRKFFITIFTDPWLASPAQIWQVYVHYLQRMDLSCVCGALSWHSLLLRGTQAIRRVKCYTSHPLELQVDPAE--VFALPAQGVQDVRVGLRALRAGSRFFYLNVVDVDTRQLVDSWLLCITCRQPVISKAFEISVPVEGGKGSNKKISFTNPYSSSRVFNLRTDRPDLLHFKEEQFQIGGGELYTIGLRFAPSQNPGMEEILIFINDKQDKNEDTYCVRVQYR 495

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BLAST of NPHP4 vs. Ensembl Zebrafish
Match: nphp4 (nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-060503-715])

HSP 1 Score: 94.3597 bits (233), Expect = 7.806e-22
Identity = 58/199 (29.15%), Postives = 94/199 (47.24%), Query Frame = 1

Query: 3817 VHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            VH   R+D+    G  +  +LLL+G      V+ +TSHP E+ V P E   F+L A    ++ + L  ++ G+R F++NVVD+++  L+ SW++C TC++P ISK       IGGG                                         ++  IG+ F P      ++I +FIND+  KNE+T+ + V Y+
Sbjct:    5 VHYLQRMDLSCVCGALSWHSLLLRGTQAIRRVKCYTSHPLELQVDPAE--VFALPAQGVQDVRVGLRALRAGSRFFYLNVVDVDTRQLVDSWLLCITCRQPVISK-------IGGG-----------------------------------------ELYTIGLRFAPSQNPGMEEILIFINDKQDKNEDTYCVRVQYR 153

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BLAST of NPHP4 vs. Ensembl Xenopus
Match: vac14 (Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921])

HSP 1 Score: 511.916 bits (1317), Expect = 8.502e-156
Identity = 304/874 (34.78%), Postives = 474/874 (54.23%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEY------QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F +ILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR   +G +   +S+FFTFQFYRF  ++T RL L  +  + S+   + P+  +L +    G+     PG  IKY +DP F+KPGE   F+ YL  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S EL++I+            D   + S+K       + GRLH+RM N+G    KK      +  P K  II                         +     + G LG    V + Q     + EL+ ++ ++    G          +  +      N  E +K +R     +Q   EN N+   L+  A+  ++ +    LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   VSIEI DS  L  IT+ QE +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY    +        P   S +R   +L+     +      ++ F+T++ K+++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D++++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  RIDV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNEETF + V Y+
Sbjct:  605 LSRASLARLHSVEFPDILDCNNEVAEVVDPS----NPVNFNLQKEEADYLLCNEIVLQFLAFTRIP-DGRTIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDNATSDPLTHVLLQINKDGSIKKGSPGYQIKYRVDPGFLKPGERKWFLRYLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHELEVITTEYEQDLMVMSGDNAKQGSAKPIGVHTIIKGRLHMRMGNVGHPAEKKLKRHETLP-PSKSRIITMHD----------------GRTSFHGGSLFSNGSLGGKYNVCQAQKLADLDSELAAMLCSRMKEVG----------ITYQQTNSEANTIERRKKERMMAVRQQESQENANLKKSLIL-AQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVSIEI-DSADLRVITDTQEWKHFKELTSTITPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVDHTPMLQGPDAES-LRKHSQLSQYKSNFMSSRRIKVSFKTSDGKVIAILQVSIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLHVRCSDTNIICDSKKMGPGEPQDVFIKVAGGPSPQIKKFFIALYIDPWLAAPIQIWQIYVHSLKRIDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSKFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEILLPVGGEKGCNKRISYRNPYPTKKTYSLHTNRTDLLQFKENYFEVGDGETYSIGLRFAPSQTSGLEEILIFINDQEDKNEETFCVKVRYE 1439

HSP 2 Score: 124.405 bits (311), Expect = 7.844e-28
Identity = 121/473 (25.58%), Postives = 212/473 (44.82%), Query Frame = 1

Query:   40 VLSEKHKYIPPPKERQGNTKADNLSF--CIKLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI-----PVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTA-------KNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLP------QHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK--PDSV----LRKIEQGDGEFT--AGEKN 1356
            + S+ H  IPP K+R  +   +   +  CI+ L+     + V + +  +   ++ +LFD  Y  FFG+ W SS             +  N+PIYFYT   D  +  + E++    + + +  G      L C   +  L S+   +  SI      +Y GT R+L    LK   E + ++   EN+ +  S+  HK       L+PE  LV   + I G+   ++   D  + P + K     ++++ +F+ PSL +FE+EL   +NND L +D  +   +   + I ERRL +GVHNG ++++    +   V  P+         +S+ K+     L++       ++ I +  M N + F +VF+LEY  + P         GI S  P       + + +RW  + P  +K +        + L   GG    P + LVYK  P ++    ++++E G   FT  +G +N
Sbjct:   17 IFSQCH-IIPPHKQRCKHVPFEKAGYQICIETLEGTPVRQGVLERSVEVCCQLRVTLFDSTYHHFFGRTWKSSAKPLKATPGKGSKILFNEPIYFYTTLCDPSIMAVIEVVALTKKQDGSKQG------LSCGFGIMGLFSHPLEDDSSIQNKRLKLYYGTPRSLLHPTLKDPNELNQQMTLLENTSIQYSVRPHKVLQTVAHLLPENVLVSGSETIPGIIPSSDESGDALKKPHVQKTVVCYLDQICLFLYPSLEKFEEELTVLVNNDWLPKDDGNI--NGGCVSIQERRLHIGVHNGWVFVQKPQIV---VVVPEAEMMRGHSTTSLKKNVTQQKLSSTVQALVLRSRIRLPEMVNHRGFALVFLLEYVFSIPN--------GIHSKTPSAASSTSYMHMIRWAAWTPSLEKGSS------EVALPLQGGPHPNPSSNLVYKMPPANMSSEEVQQVESGTVHFTFCSGSEN 463

[Close]

BLAST of NPHP4 vs. Ensembl Xenopus
Match: vac14 (Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921])

HSP 1 Score: 507.294 bits (1305), Expect = 2.173e-155
Identity = 306/874 (35.01%), Postives = 473/874 (54.12%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEY------QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F +ILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR   +G +   +S+FFTFQFYRF  ++T RL L  +  + S+   + P+  +L +    G+     PG  IKY +DP F+KPGE   F+ YL  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S EL++I+            D   + S+K       + GRLH+RM N+G    KK      +  P K  II                         +     + G LG  N V + Q     + EL+ ++ ++    G          +  +      N  E +K +R     +Q   EN N+   L+   +          LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   VSIEI DS  L  IT+ QE +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY        Q+F  P   S +R   +L+     +      ++ F+T++ K+++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D++++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  RIDV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNEETF + V Y+
Sbjct:  477 LSRASLARLHSVEFPDILDCNNEVAEVVDPS----NPVNFNLQKEEADYLLCNEIVLQFLAFTRIP-DGRTIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDNATSDPLTHVLLQINKDGSIKKGSPGYQIKYRVDPGFLKPGERKWFLRYLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHELEVITTEYEQDLMVMSGDNAKQGSAKPIGVHTIIKGRLHMRMGNVGHPAEKKLKRHETLP-PSKSRIITMHD----------------GRTSFHGGSLFSNGSLGKYN-VCQAQKLADLDSELAAMLCSRMKEVG----------ITYQQTNSEANTIERRKKERMMAVRQQESQENANLKKSLILHTRD---------LQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVSIEI-DSADLRVITDTQEWKHFKELTSTITPIEENMFHVQPNTVIPQLYLRAKETVYIPFKY--------QTFCGPDAES-LRKHSQLSQYKSNFMSSRRIKVSFKTSDGKVIAILQVSIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLHVRCSDTNIICDSKKMGPGEPQDVFIKVAGGPSPQIKKFFIALYIDPWLAAPIQIWQIYVHSLKRIDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSKFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEILLPVGGEKGCNKRISYRNPYPTKKTYSLHTNRTDLLQFKENYFEVGDGETYSIGLRFAPSQTSGLEEILIFINDQEDKNEETFCVKVRYE 1294

HSP 2 Score: 107.071 bits (266), Expect = 1.735e-22
Identity = 100/392 (25.51%), Postives = 169/392 (43.11%), Query Frame = 1

Query:  184 IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI-----PVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTA-------KNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLP------QHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK 1293
            ++ +LFD  Y  FFG+ W SS             +  N+PIYFYT   D  +  + E++    + + +  G      L C   +  L S+   +  SI      +Y GT R+L    LK   E + ++   EN+ +  S+  HK       L+PE  LV   + I G+   ++   D  + P + K     ++++ +F+ PSL +FE+EL        +  DG     +   + I ERRL +GVHNG ++++    +   V  P+         +S+ K+     L++       ++ I +  M N + F +VF+LEY  + P         GI S  P       + + +RW  + P  +K +        + L   GG    P + LVYK
Sbjct:   21 LRVTLFDSTYHHFFGRTWKSSAKPLKATPGKGSKILFNEPIYFYTTLCDPSIMAVIEVVALTKKQDGSKQG------LSCGFGIMGLFSHPLEDDSSIQNKRLKLYYGTPRSLLHPTLKDPNELNQQMTLLENTSIQYSVRPHKVLQTVAHLLPENVLVSGSETIPGIIPSSDESGDALKKPHVQKTVVCYLDQICLFLYPSLEKFEEEL-------TVLDDGNI---NGGCVSIQERRLHIGVHNGWVFVQKPQIV---VVVPEAEMMRGHSTTSLKKNVTQQKLSSTVQALVLRSRIRLPEMVNHRGFALVFLLEYVFSIPN--------GIHSKTPSAASSTSYMHMIRWAAWTPSLEKGSS------EVALPLQGGPHPNPSSNLVYK 379

[Close]

BLAST of NPHP4 vs. Ensembl Xenopus
Match: vac14 (Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921])

HSP 1 Score: 507.294 bits (1305), Expect = 4.808e-155
Identity = 305/879 (34.70%), Postives = 471/879 (53.58%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIV-----------FRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F +ILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR   +G +   +S+FFTFQFYRF  ++T RL L  +  + S+   + P+  +L +    G+     PG  IKY +DP F+KPGE   F+ YL  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S EL++I+            D   + S+K       + GRLH+RM N+G    KK      +  P K  II                         +     + G LG    V + Q     + EL+ ++ ++    G          +  +      N  E +K +R     +Q   EN N+   L+  A+  ++ +    LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   VSIEI DS  L  IT+ QE +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY    +          M    +  H    +  EY I            F+T++ K+++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D++++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  RIDV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNEETF + V Y+
Sbjct:  494 LSRASLARLHSVEFPDILDCNNEVAEVVDPS----NPVNFNLQKEEADYLLCNEIVLQFLAFTRIP-DGRTIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDNATSDPLTHVLLQINKDGSIKKGSPGYQIKYRVDPGFLKPGERKWFLRYLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHELEVITTEYEQDLMVMSGDNAKQGSAKPIGVHTIIKGRLHMRMGNVGHPAEKKLKRHETLP-PSKSRIITMHD----------------GRTSFHGGSLFSNGSLGGKYNVCQAQKLADLDSELAAMLCSRMKEVG----------ITYQQTNSEANTIERRKKERMMAVRQQESQENANLKKSLIL-AQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVSIEI-DSADLRVITDTQEWKHFKELTSTITPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVDHT------PMLQVCKLYHPCLRIINEYNITLSIFSRFLKVSFKTSDGKVIAILQVSIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLHVRCSDTNIICDSKKMGPGEPQDVFIKVAGGPSPQIKKFFIALYIDPWLAAPIQIWQIYVHSLKRIDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSKFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEILLPVGGEKGCNKRISYRNPYPTKKTYSLHTNRTDLLQFKENYFEVGDGETYSIGLRFAPSQTSGLEEILIFINDQEDKNEETFCVKVRYE 1328

HSP 2 Score: 120.553 bits (301), Expect = 1.075e-26
Identity = 103/392 (26.28%), Postives = 174/392 (44.39%), Query Frame = 1

Query:  184 IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI-----PVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTA-------KNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLP------QHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK 1293
            ++ +LFD  Y  FFG+ W SS             +  N+PIYFYT   D  +  + E++    + + +  G      L C   +  L S+   +  SI      +Y GT R+L    LK   E + ++   EN+ +  S+  HK       L+PE  LV   + I G+   ++   D  + P + K     ++++ +F+ PSL +FE+EL   +NND L +D  +   +   + I ERRL +GVHNG ++++    +   V  P+         +S+ K+     L++       ++ I +  M N + F +VF+LEY  + P         GI S  P       + + +RW  + P  +K +        + L   GG    P + LVYK
Sbjct:   21 LRVTLFDSTYHHFFGRTWKSSAKPLKATPGKGSKILFNEPIYFYTTLCDPSIMAVIEVVALTKKQDGSKQG------LSCGFGIMGLFSHPLEDDSSIQNKRLKLYYGTPRSLLHPTLKDPNELNQQMTLLENTSIQYSVRPHKVLQTVAHLLPENVLVSGSETIPGIIPSSDESGDALKKPHVQKTVVCYLDQICLFLYPSLEKFEEELTVLVNNDWLPKDDGNI--NGGCVSIQERRLHIGVHNGWVFVQKPQIV---VVVPEAEMMRGHSTTSLKKNVTQQKLSSTVQALVLRSRIRLPEMVNHRGFALVFLLEYVFSIPN--------GIHSKTPSAASSTSYMHMIRWAAWTPSLEKGSS------EVALPLQGGPHPNPSSNLVYK 387

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BLAST of NPHP4 vs. Ensembl Xenopus
Match: vac14 (Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921])

HSP 1 Score: 502.671 bits (1293), Expect = 6.561e-154
Identity = 303/868 (34.91%), Postives = 466/868 (53.69%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F +ILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR   +G +   +S+FFTFQFYRF  ++T RL L  +  + S+   + P+  +L +    G+     PG  IKY +DP F+KPGE   F+ YL  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S EL++I+            D   + S+K       + GRLH+RM N+G    KK      +  P K  II                         +     + G LG    V + Q     + EL+ ++ ++    G          +  +      N  E +K +R     +Q   EN N+   L+  A+  ++ +    LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   VSIEI DS  L  IT+ QE +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY    +                TP  L     + Q+  R    K+++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D++++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  RIDV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNEETF + V Y+
Sbjct:  457 LSRASLARLHSVEFPDILDCNNEVAEVVDPS----NPVNFNLQKEEADYLLCNEIVLQFLAFTRIP-DGRTIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDNATSDPLTHVLLQINKDGSIKKGSPGYQIKYRVDPGFLKPGERKWFLRYLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHELEVITTEYEQDLMVMSGDNAKQGSAKPIGVHTIIKGRLHMRMGNVGHPAEKKLKRHETLP-PSKSRIITMHD----------------GRTSFHGGSLFSNGSLGGKYNVCQAQKLADLDSELAAMLCSRMKEVG----------ITYQQTNSEANTIERRKKERMMAVRQQESQENANLKKSLIL-AQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVSIEI-DSADLRVITDTQEWKHFKELTSTITPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVD--------------HTP-MLQVCKCKCQLGPRCNNGKVIAILQVSIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLHVRCSDTNIICDSKKMGPGEPQDVFIKVAGGPSPQIKKFFIALYIDPWLAAPIQIWQIYVHSLKRIDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSKFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEILLPVGGEKGCNKRISYRNPYPTKKTYSLHTNRTDLLQFKENYFEVGDGETYSIGLRFAPSQTSGLEEILIFINDQEDKNEETFCVKVRYE 1271

HSP 2 Score: 110.923 bits (276), Expect = 1.047e-23
Identity = 98/385 (25.45%), Postives = 168/385 (43.64%), Query Frame = 1

Query:  184 IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI-----PVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKH------EEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK 1293
            ++ +LFD  Y  FFG+ W SS             +  N+PIYFYT   D  +  + E++    + + +  G      L C   +  L S+   +  SI      +Y GT R+L    LK   E + ++   EN+ +  S+  HK       L+PE  LV   + I G+   ++   D  + P + K     ++++ +F+ PSL +FE+EL        +  DG     +   + I ERRL +GVHNG ++++    +   V  P+         +S+ K+           L  ++ I +  M N + F +VF+LEY  + P   +G    G+ +    + + +RW  + P  +K +        + L   GG    P + LVYK
Sbjct:   21 LRVTLFDSTYHHFFGRTWKSSAKPLKATPGKGSKILFNEPIYFYTTLCDPSIMAVIEVVALTKKQDGSKQG------LSCGFGIMGLFSHPLEDDSSIQNKRLKLYYGTPRSLLHPTLKDPNELNQQMTLLENTSIQYSVRPHKVLQTVAHLLPENVLVSGSETIPGIIPSSDESGDALKKPHVQKTVVCYLDQICLFLYPSLEKFEEEL-------TVLDDGNI---NGGCVSIQERRLHIGVHNGWVFVQKPQIV---VVVPEAEMMRGHSTTSLKKNYILSNSSTVQALVLRSRIRLPEMVNHRGFALVFLLEYVFSIP---NGIHKGGLSASSTSYMHMIRWAAWTPSLEKGSS------EVALPLQGGPHPNPSSNLVYK 377

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BLAST of NPHP4 vs. Ensembl Xenopus
Match: vac14 (Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921])

HSP 1 Score: 503.056 bits (1294), Expect = 1.627e-153
Identity = 301/873 (34.48%), Postives = 469/873 (53.72%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLE-----YQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F +ILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR      +   +S+FFTFQFYRF  ++T RL L  +  + S+   + P+  +L +    G+     PG  IKY +DP F+KPGE   F+ YL  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S EL++I+            D   + S+K       + GRLH+RM N+G    KK      +  P K  II                         +     + G LG    V + Q     + EL+ ++ ++    G          +  +      N  E +K +R     +Q   EN N+   L+  A+  ++ +    LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   VSIEI DS  L  IT+ QE +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY    +          +  P        ++ L       ++ F+T++ K+++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D++++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  RIDV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNEETF + V Y+
Sbjct:  492 LSRASLARLHSVEFPDILDCNNEVAEVVDPS----NPVNFNLQKEEADYLLCNEIVLQFLAFTR------TIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDNATSDPLTHVLLQINKDGSIKKGSPGYQIKYRVDPGFLKPGERKWFLRYLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHELEVITTEYEQDLMVMSGDNAKQGSAKPIGVHTIIKGRLHMRMGNVGHPAEKKLKRHETLP-PSKSRIITMHD----------------GRTSFHGGSLFSNGSLGGKYNVCQAQKLADLDSELAAMLCSRMKEVG----------ITYQQTNSEANTIERRKKERMMAVRQQESQENANLKKSLIL-AQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVSIEI-DSADLRVITDTQEWKHFKELTSTITPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVDHTPMLQVCKLYHPCLRIINEYNITLSIFSRFLKVSFKTSDGKVIAILQVSIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLHVRCSDTNIICDSKKMGPGEPQDVFIKVAGGPSPQIKKFFIALYIDPWLAAPIQIWQIYVHSLKRIDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSKFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEILLPVGGEKGCNKRISYRNPYPTKKTYSLHTNRTDLLQFKENYFEVGDGETYSIGLRFAPSQTSGLEEILIFINDQEDKNEETFCVKVRYE 1321

HSP 2 Score: 121.709 bits (304), Expect = 5.819e-27
Identity = 110/421 (26.13%), Postives = 189/421 (44.89%), Query Frame = 1

Query:  184 IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI-----PVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTA-------KNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLP------QHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK--PDSV----LRKIEQGDGEFT--AGEKN 1356
            ++ +LFD  Y  FFG+ W SS             +  N+PIYFYT   D  +  + E++    + + +  G      L C   +  L S+   +  SI      +Y GT R+L    LK   E + ++   EN+ +  S+  HK       L+PE  LV   + I G+   ++   D  + P + K     ++++ +F+ PSL +FE+EL   +NND L +D  +   +   + I ERRL +GVHNG ++++    +   V  P+         +S+ K+     L++       ++ I +  M N + F +VF+LEY  + P         GI S  P       + + +RW  + P  +K +        + L   GG    P + LVYK  P ++    ++++E G   FT  +G +N
Sbjct:   21 LRVTLFDSTYHHFFGRTWKSSAKPLKATPGKGSKILFNEPIYFYTTLCDPSIMAVIEVVALTKKQDGSKQG------LSCGFGIMGLFSHPLEDDSSIQNKRLKLYYGTPRSLLHPTLKDPNELNQQMTLLENTSIQYSVRPHKVLQTVAHLLPENVLVSGSETIPGIIPSSDESGDALKKPHVQKTVVCYLDQICLFLYPSLEKFEEELTVLVNNDWLPKDDGNI--NGGCVSIQERRLHIGVHNGWVFVQKPQIV---VVVPEAEMMRGHSTTSLKKNVTQQKLSSTVQALVLRSRIRLPEMVNHRGFALVFLLEYVFSIPN--------GIHSKTPSAASSTSYMHMIRWAAWTPSLEKGSS------EVALPLQGGPHPNPSSNLVYKMPPANMSSEEVQQVESGTVHFTFCSGSEN 416

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BLAST of NPHP4 vs. Ensembl Mouse
Match: Nphp4 (nephronophthisis 4 (juvenile) homolog (human) [Source:MGI Symbol;Acc:MGI:2384210])

HSP 1 Score: 540.421 bits (1391), Expect = 1.450e-166
Identity = 428/1521 (28.14%), Postives = 697/1521 (45.83%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHT----YQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF-----TAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNV-VNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSE-AKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAM--------SSPVRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASH-----NEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +PP  +R      ++ +F CI K LD  L  + + D    +  +++ +LFD  Y+ FFG+ W ++             +  N+P+YF+T      +  + E++    + + T        LL C   +  +  NK     S      + +Y GT RAL    L+   E +  ++  EN  L  ++  H   +    L+PE  LV     I GL   +    D    PR  K   + ++ +   + PSL +FE+EL++ + +DR   +G   + D+ +L ++ERRL V VHNG+ +++    + L    +V   +    S +  +S      +  L  ++ + +  M +   F IVF LEY    P  +DG    G  SP    +    + VRW V+ P      +    G ++ L   GG    P   LVYK  S       ++++E G  +F     + G   ++    V R         S  +  SP+     +  D    ++S     P  P    ++LT S    L   ++      +Q        +   +Q E++ +     +   +S P  +   P   H+  + +T                                +    Q RS     LSRA    + ++GF EILD + +    ++P    D V  N + EE D  + NEI+ QF+A +R   D  G   P ++V+FTFQFYRFP  +T RL L  +     +   +   IL      G+     PG  ++YM+DP F+KPGE   F  YL  QTL VDVWDGDSLLLIGS  V++++L RQG+ +VQ S EL++++            D+    S K       + GRLH+ +AN+G     +  G  L+  P +  +I    AS   G S                     I GG       VV+ Q     + EL+ ++ T  H++  +      GP        G   D   K K  +  L +L+    + + + +S  A+ S + +    LQ I  YRE+ K E I   L+  I     +Y   G  E FE  +KN  N    V+IEI DS  L  I ++QE R  K    + T  E D+ +        Q+++R +E+  IP K+ + ++       +PA         S P+    K +++  ++ +++FR    +L+++L + V PQP ++DQ FRF+HPE +FL++ IR+PP H +         E   +  RC+D +V+ E      G P D+ LKV  GPSP+++ F + +Y D++L  P+Q W   +HS  R+DV    GQ T ++L+L+G      V+ FTSHP+E+   P     F L  H   +L + + P + G+R  H+N+VDI+ H L+ SW++C +C++P ISK FE+ +  G  +   KRI + NPYP ++ + L +DRP+L+  K+    +   +   IG+ F+P     +++I ++IND + KNEETF + V YQ
Sbjct:   14 VPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGT------LQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR---EGVGLL-DSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADG----GASSPTSISSVACMHMVRWAVWNP-----DLEVGPG-KVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRS-------SRKMPASPSGTPAPAARDLAATQDS-----PVGPGLSLSQLTAS---PLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPL---------------------------HAPIVVGAQTRSSRS-QLSRAAMVLLQSSGFPEILDASQQPVEAVNPI---DPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWP-QTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLP-PSRSRVISNDGASFFSGGSLL-------------------IPGG--PKRKRVVQAQRLADVDSELAAMLLT--HTRAGQ------GPQAA-----GQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEI-DSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSL-APQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPL---WKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPA--GVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ 1425

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Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHT----YQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF-----TAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNV-VNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSE-AKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAM--------SSPVRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASH-----NEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +PP  +R      ++ +F CI K LD  L  + + D    +  +++ +LFD  Y+ FFG+ W ++             +  N+P+YF+T      +  + E++    + + T        LL C   +  +  NK     S      + +Y GT RAL    L+   E +  ++  EN  L  ++  H   +    L+PE  LV     I GL   +    D    PR  K   + ++ +   + PSL +FE+EL++ + +DR   +G   + D+ +L ++ERRL V VHNG+ +++    + L    +V   +    S +  +S      +  L  ++ + +  M +   F IVF LEY    P  +DG    G  SP    +    + VRW V+ P      +    G ++ L   GG    P   LVYK  S       ++++E G  +F     + G   ++    V R         S  +  SP+     +  D    ++S     P  P    ++LT S    L   ++      +Q        +   +Q E++ +     +   +S P  +   P   H+  + +T                                +    Q RS     LSRA    + ++GF EILD + +    ++P    D V  N + EE D  + NEI+ QF+A +R   D  G   P ++V+FTFQFYRFP  +T RL L  +     +   +   IL      G+     PG  ++YM+DP F+KPGE   F  YL  QTL VDVWDGDSLLLIGS  V++++L RQG+ +VQ S EL++++            D+    S K       + GRLH+ +AN+G     +  G  L+  P +  +I    AS   G S                     I GG       VV+ Q     + EL+ ++ T  H++  +      GP        G   D   K K  +  L +L+    + + + +S  A+ S + +    LQ I  YRE+ K E I   L+  I     +Y   G  E FE  +KN  N    V+IEI DS  L  I ++QE R  K    + T  E D+ +        Q+++R +E+  IP K+ + ++       +PA         S P+    K +++  ++ +++FR    +L+++L + V PQP ++DQ FRF+HPE +FL++ IR+PP H +         E   +  RC+D +V+ E      G P D+ LKV  GPSP+++ F + +Y D++L  P+Q W   +HS  R+DV    GQ T ++L+L+G      V+ FTSHP+E+   P     F L  H   +L + + P + G+R  H+N+VDI+ H L+ SW++C +C++P ISK FE+ +  G  +   KRI + NPYP ++ + L +DRP+L+  K+    +   +   IG+ F+P     +++I ++IND + KNEETF + V YQ
Sbjct:   14 VPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGT------LQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR---EGVGLL-DSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADG----GASSPTSISSVACMHMVRWAVWNP-----DLEVGPG-KVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRS-------SRKMPASPSGTPAPAARDLAATQDS-----PVGPGLSLSQLTAS---PLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPL---------------------------HAPIVVGAQTRSSRS-QLSRAAMVLLQSSGFPEILDASQQPVEAVNPI---DPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWP-QTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLP-PSRSRVISNDGASFFSGGSLL-------------------IPGG--PKRKRVVQAQRLADVDSELAAMLLT--HTRAGQ------GPQAA-----GQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEI-DSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSL-APQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPL---WKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPA--GVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ 1425

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BLAST of NPHP4 vs. UniProt/SwissProt
Match: sp|P59240|NPHP4_MOUSE (Nephrocystin-4 OS=Mus musculus OX=10090 GN=Nphp4 PE=1 SV=2)

HSP 1 Score: 540.421 bits (1391), Expect = 1.014e-165
Identity = 428/1521 (28.14%), Postives = 697/1521 (45.83%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHT----YQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF-----TAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNV-VNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSE-AKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAM--------SSPVRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASH-----NEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            +PP  +R      ++ +F CI K LD  L  + + D    +  +++ +LFD  Y+ FFG+ W ++             +  N+P+YF+T      +  + E++    + + T        LL C   +  +  NK     S      + +Y GT RAL    L+   E +  ++  EN  L  ++  H   +    L+PE  LV     I GL   +    D    PR  K   + ++ +   + PSL +FE+EL++ + +DR   +G   + D+ +L ++ERRL V VHNG+ +++    + L    +V   +    S +  +S      +  L  ++ + +  M +   F IVF LEY    P  +DG    G  SP    +    + VRW V+ P      +    G ++ L   GG    P   LVYK  S       ++++E G  +F     + G   ++    V R         S  +  SP+     +  D    ++S     P  P    ++LT S    L   ++      +Q        +   +Q E++ +     +   +S P  +   P   H+  + +T                                +    Q RS     LSRA    + ++GF EILD + +    ++P    D V  N + EE D  + NEI+ QF+A +R   D  G   P ++V+FTFQFYRFP  +T RL L  +     +   +   IL      G+     PG  ++YM+DP F+KPGE   F  YL  QTL VDVWDGDSLLLIGS  V++++L RQG+ +VQ S EL++++            D+    S K       + GRLH+ +AN+G     +  G  L+  P +  +I    AS   G S                     I GG       VV+ Q     + EL+ ++ T  H++  +      GP        G   D   K K  +  L +L+    + + + +S  A+ S + +    LQ I  YRE+ K E I   L+  I     +Y   G  E FE  +KN  N    V+IEI DS  L  I ++QE R  K    + T  E D+ +        Q+++R +E+  IP K+ + ++       +PA         S P+    K +++  ++ +++FR    +L+++L + V PQP ++DQ FRF+HPE +FL++ IR+PP H +         E   +  RC+D +V+ E      G P D+ LKV  GPSP+++ F + +Y D++L  P+Q W   +HS  R+DV    GQ T ++L+L+G      V+ FTSHP+E+   P     F L  H   +L + + P + G+R  H+N+VDI+ H L+ SW++C +C++P ISK FE+ +  G  +   KRI + NPYP ++ + L +DRP+L+  K+    +   +   IG+ F+P     +++I ++IND + KNEETF + V YQ
Sbjct:   14 VPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGT------LQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDR---EGVGLL-DSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADG----GASSPTSISSVACMHMVRWAVWNP-----DLEVGPG-KVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRS-------SRKMPASPSGTPAPAARDLAATQDS-----PVGPGLSLSQLTAS---PLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPL---------------------------HAPIVVGAQTRSSRS-QLSRAAMVLLQSSGFPEILDASQQPVEAVNPI---DPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWP-QTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLP-PSRSRVISNDGASFFSGGSLL-------------------IPGG--PKRKRVVQAQRLADVDSELAAMLLT--HTRAGQ------GPQAA-----GQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEI-DSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSL-APQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPL---WKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPA--GVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ 1425

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BLAST of NPHP4 vs. UniProt/SwissProt
Match: sp|B0DOB4|NPHP4_XENLA (Nephrocystin-4 OS=Xenopus laevis OX=8355 GN=nphp4 PE=2 SV=1)

HSP 1 Score: 517.694 bits (1332), Expect = 3.048e-157
Identity = 308/876 (35.16%), Postives = 484/876 (55.25%), Query Frame = 1

Query: 1888 LSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFEL--EERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPM--ILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLG--YSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKL------ASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            LSRA  +++++  F EILDCN E   V+DP+    N VNF L  EE D+  CNEI+ QF+A TR   +G++   +S+FFTFQFYRF  ++T RL L  +  + S+   A P+  +L +    G+     PG  IKY +DP F+KPGE   F+ +L  QTL +D+WDG+SLLLIGS AV++++L RQG+ +VQ S +L++I+            D   + ++K       + GRLH+RM N+G  P KK          K+   +  S                   R I   D  TG H G   SN  +  + ++ +  +L++L +++  +     M  V   +  +     T+  E +K +R     +Q   EN N+   L+  A+  ++ +    LQ I+ YRE+ K E I   LN  I     +Y   G  E FE ++KN +NI   V+IEI DS  L  IT+ +E +  K + S  T  E ++ +      I Q+++R+KE+V IPFKY    +        P   S +R   +L      A      ++ F+T++ KL++IL+V + PQP ++DQTFRF+HPE +FL++ IR+PP +      + +      +  RC+D +++ +      G P D+ +KV  GPSPQ+++F +ALYID +L  PIQ+W   VHS  R+DV    GQ T ++L+L+G      V+ ++SHPEE+ V P  +  F L  +   +L + + P K G++  ++N+VD++ H L+ SW++C +C++P ISK FE+ LP+GG + C KRI ++NPYP +K + L T+R DL+  K+    + A +  +IG+ F P   R +++I +FIND + KNEETF + V Y+
Sbjct:  596 LSRASLARLHSVEFPEILDCNNEVAEVVDPS----NPVNFNLQREEADYLLCNEIVLQFLAFTRIH-DGSTIWPESIFFTFQFYRFHHVTTPRLQLLQL--ESSDIATADPLTHVLVQINKDGSIKKGSPGFQIKYSVDPGFLKPGERKWFLRFLALQTLQIDIWDGESLLLIGSAAVEMKHLLRQGRTAVQVSHDLEVITTEYEQDLMVMSGDTAKQGTAKPIGVHTIIKGRLHMRMGNVGRPPEKKL---------KRRETLPPSN-----------------SRIITMHDGRTGFHGGSMLSNKSMNWKQSVCQAHKLADL-DSELAAMLCSRMKEVS--IAYQQTNSETDTTERRKKERMMAVRQQESQENANLRKSLIM-AQHEERTQHTRDLQIIEAYRERTKPECISSMLNQAITSNYTVYATLGTAEFFEFELKNPYNIQYTVTIEI-DSTDLRVITDTREWKHFKELTSTVTPIEENMFHVQPNTVIPQLYLRAKETVYIPFKYQTFCVDHTPMLQGPDAES-LRKHSQLSQYKSNAMSSRRIKVSFKTSDGKLIAILQVNIEPQPHVVDQTFRFYHPELTFLKKSIRLPPWYTLPGAPVGTPGGEPDLQVRCSDINIICDSKKMGPGEPQDVFIKVAGGPSPQIKRFFIALYIDPWLAAPIQIWQIYVHSLKRVDVSCITGQLTQLSLVLRGTQVVRKVRAYSSHPEELKVDP--DGVFVLPPNGIQDLHIGVRPQKAGSQFIYLNLVDVDQHQLVASWLVCVSCRKPVISKAFEIALPVGGEKGCNKRISYRNPYPTKKTYSLYTNRSDLLQFKENYFEVAAGETYSIGLRFAPSQTRGQEEILIFINDREDKNEETFCVKVRYE 1430

HSP 2 Score: 127.487 bits (319), Expect = 5.845e-28
Identity = 119/471 (25.27%), Postives = 211/471 (44.80%), Query Frame = 1

Query:   40 VLSEKHKYIPPPKERQGNTKADNLSF--CIKLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEII----RYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL--EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEH-----NCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLP------QHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK--PDSV----LRKIEQGDGEFT--AGEKN 1356
            + S+ H  IPP K+R  +  ++   +  CI+ L+     + V + +  +   ++ +LFD  Y  FFG+ W SST            +  N+PIYFYT  +D  +  + E++    +      +   G+ + +L         L  +   ++  + +Y GT R+L    LK   E +  +   EN+ +  S+  HK       L PE  LV   + I G+    DN G    + P + K     ++++ +F+ P+L +FE+EL   +N+D L +D  +   +  S+ I ERRL +GVHNG ++++    + +  +   +R  ST      +  ++        L  ++ I +  M N   F +VF+LEY  + P         GI S  P       + + +RW  + P  ++ +        + L   GG    P N LVYK  P ++    ++++E G   FT  AG +N
Sbjct:    7 IFSQSH-IIPPHKQRCKHAPSEKAGYQICIETLEGTPFRQGVLERSVEVSCQLRMTLFDSTYHHFFGRTWKSSTKPIKAIPGKASKILFNEPIYFYTTLIDPSIMAVIEVVALSKKQGGSKQELSCGFGIMSLFS-----HQLEDDSSIQSGRLKLYYGTPRSLLHPTLKDPNELNQHMTLIENTCIQYSVRPHKVLPTVAHLFPENVLVSGSETIPGIMPSCDNSGDA-LKKPHVQKTVICYLDQICLFLYPTLEKFEEELTMLVNSDWLPKDDGNI--NGGSVSIQERRLHIGVHNGWVFVQKPQIVVVVPEAEMMRGHSTTSLKKKNIAQQKLSSTVQALVLRSRIRLPEMVNHHGFALVFLLEYVFSIPN--------GIHSKTPSAASSTSYMHMIRWASWTPSMEQGSAD------VALPLQGGPHHNPSNNLVYKMPPANMSSEEVQQVESGTVHFTFCAGSEN 454

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BLAST of NPHP4 vs. UniProt/SwissProt
Match: sp|O75161|NPHP4_HUMAN (Nephrocystin-4 OS=Homo sapiens OX=9606 GN=NPHP4 PE=1 SV=2)

HSP 1 Score: 455.677 bits (1171), Expect = 8.384e-135
Identity = 289/886 (32.62%), Postives = 458/886 (51.69%), Query Frame = 1

Query: 1861 QMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRF--DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN------------------SSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIID---ASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSE-AKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNM-ALQADQSFASPAMSSP----VRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            Q RS  G   SRA    + ++GF EILD N +    +  +  +    N + EE D  Q NE++ QF+A +R   D  G S P K+V+FTFQFYRFP  +T RL L  + +       A   IL      G      PG  ++YM+ P F+KPGE   F  YL  QTL +DVWDGDSLLLIGS AV++++L RQG+ +VQ+S EL++++  + + +N                   S + GRLH+ +AN+G    +K  G + +  P +  +I    AS+  G                 +  T      H      VV+ Q     + EL+ ++ T +           KGP   +D+ R ++    +KL+R ++   +L+    ++  +  S  A++S + +    LQ I  YRE+ K E I   L+  I  E  ++   G  E FE  +KN  N    V++EI++    V I ++QE R  K    + T  E D+ +        Q+++R  E+  +PFK+ +  A Q     ASP +S+       +P K ++V  ++ +++FR +  K +++L + V  QP ++DQ FRF+HPE SFL++ IR+PP H      +    E   +  RC+D +V+ E      G P DI LKV  GPSP+++ F + +Y D++L  P Q W   +HS  R+DV    GQ T ++L+L+G      V+ FTSHP+E+   P     F L      +L + + P++ G+R  H+N+VD++ H L+ SW++C  C++P ISK FE+ L  G G+   KRI + NPYP ++ F+L +D P+L+  ++    +   +   IG+ F P  +   ++I ++IND + KNEE F + V YQ
Sbjct:  585 QTRSSAGQP-SRASMVLLQSSGFPEILDANKQPAEAV--SATEPVTFNPQKEESDCLQSNEMVLQFLAFSRVAQDCRGTSWP-KTVYFTFQFYRFPPATTPRLQLVQLDEAGQPSSGALTHILVPVSRDGTFDAGSPGFQLRYMVGPGFLKPGERRCFARYLAVQTLQIDVWDGDSLLLIGSAAVQMKHLLRQGRPAVQASHELEVVA-TEYEQDNMVVSGDMLGFGRVKPIGVHSVVKGRLHLTLANVGHPCEQKVRGCSTLP-PSRSRVISNDGASRFSG---------------GSLLTTGSSRRKH------VVQAQKLADVDSELAAMLLTHARQG--------KGP---QDVSRESDATRRRKLERMRSV--RLQEAGGDLGRRGTSVLAQQSVRTQHLRDLQVIAAYRERTKAESIASLLSLAITTEHTLHATLGVAEFFEFVLKNPHNTQHTVTVEIDNPELSV-IVDSQEWRDFKGAAGLHTPVEEDMFHLRGSL-APQLYLRPHETAHVPFKFQSFSAGQLAMVQASPGLSNEKGMDAVSPWKSSAVPTKHAKVLFRASGGKPIAVLCLTVELQPHVVDQVFRFYHPELSFLKKAIRLPPWHTFPGAPVGMLGEDPPVHVRCSDPNVICETQNVGPGEPRDIFLKVASGPSPEIKDFFVIIYSDRWLATPTQTWQVYLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDP--KGVFVLPPRGVQDLHVGVRPLRAGSRFVHLNLVDVDCHQLVASWLVCLCCRQPLISKAFEIMLAAGEGKGVNKRITYTNPYPSRRTFHLHSDHPELLRFREDSFQVGGGETYTIGLQFAPSQRVGEEEILIYINDHEDKNEEAFCVKVIYQ 1426

HSP 2 Score: 103.605 bits (257), Expect = 1.164e-20
Identity = 119/451 (26.39%), Postives = 193/451 (42.79%), Query Frame = 1

Query:   64 IPPPKERQGNTKADNLSF-CI-KLLDLDLSSRLVPDTNENI--YIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRY-KTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETIS------IPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL-EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGR-KDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEF 1338
            +PP  +R      ++ +F C+ K LD  +  + V +    +  +++ S FD  Y+ FFG+ W ++          I     N+P+YF+T+    ++  + E++   K  D       C F +L+       + SN+    IS      + +Y GT RAL    L+   E +  +   EN  L  ++  H A +    L+PE  LV     I GL     E       PRL K     ++ +   + PSL +FE+ELLE    D  +        D  +L I+ERRLRVGVHNG+ +++    + L    +V   +    S +  SS         L  ++ + +  M     F ++F LEY  + P   DG    +  +S L    + VRW V+ P  +       D  R+ L   GG    P + LVYK  S       ++++E G   F
Sbjct:   14 VPPHPQRARQPWKESTAFQCVLKWLDGPVIRQGVLEVLSEVECHLRVSFFDVTYRHFFGRTWKTTVKPTKRPPSRIV---FNEPLYFHTSLNHPHIVAVVEVVAEGKKRDGSLQTLSCGFGILR-------IFSNQPDSPISASQDKRLRLYHGTPRALLHPLLQDPAEQNRHMTLIENCSLQYTLKPHPALEPAFHLLPENLLVSGLQQIPGLLPAHGESGDALRKPRLQKPITGHLDDLFFTLYPSLEKFEEELLELHVQDHFQEGCGPL--DGGALEILERRLRVGVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKVVSSSKTSSGSQALVLRSRLRLPEMVGHPAFAVIFQLEYVFSSPAGVDGNAASVTSLSNL-ACMHMVRWAVWNPLLEA------DSGRVTLPLQGGIQPNPSHCLVYKVPSASMSSEEVKQVESGTLRF 445

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BLAST of NPHP4 vs. TrEMBL
Match: A0A0H3YJI8 (NPHP4 OS=Schmidtea mediterranea OX=79327 GN=NPHP4 PE=2 SV=1)

HSP 1 Score: 2933.67 bits (7604), Expect = 0.000e+0
Identity = 1462/1462 (100.00%), Postives = 1462/1462 (100.00%), Query Frame = 1

Query:   28 MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQIRRTSTRRPSSISKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEDKIVDYDVIDPYVVNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYSKASLSSSKLGGSLRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ
Sbjct:    1 MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQIRRTSTRRPSSISKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEDKIVDYDVIDPYVVNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYSKASLSSSKLGGSLRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 1462

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BLAST of NPHP4 vs. TrEMBL
Match: W5MFT0 (Nephrocystin 4 OS=Lepisosteus oculatus OX=7918 GN=NPHP4 PE=4 SV=1)

HSP 1 Score: 592.423 bits (1526), Expect = 0.000e+0
Identity = 438/1531 (28.61%), Postives = 713/1531 (46.57%), Query Frame = 1

Query:   49 EKHKYIPPPKERQGNTKADNLSFCIKLLDLD---LSSRLVPDTNENIY-IKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFM--DEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDL-HSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLE--VDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEE--------HNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKT---------KLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNF--ELEERDHKQCNEIIFQFMALTRF-DVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDD-----------------ENSSKLSGRLHIRMANLG---SVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSE-LIETKS------HSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPA-----MSSPVRTPHKLASVDLEY-QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMI-----ASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            EK + IPP  +R    + ++  F I L  L+   +  RL+       Y ++ SLFD  ++  FG+ W SS  +        + +  N+ +YF+T+         V    +  K + +   +G C F +L+     T+   ++   +   + +Y GT R L    L    E +  VK  + + +  S+  H A +    L+P+  LV   + I G+    DN G C    PRL K     ++K+ V + PS  +FE++LL+ +N DRL R+      D + + ++ERRL VG+HNG  ++     + L   DP+         S   +            + L  ++ + +  M N   F+IVF LEY  + PV  +G+     +         +RW V+ PF +  +   ++   + L   GGS   P   +VY+  S       + ++E G   F    +            D  E  P  S+         GS  DE+  +      +PP P  R++         +  +   +++           +  +    +QQ +  Q       +  Q+S++         +PF + + ++     L               + +  FT  V    +A   QM S     +SR   + +++ GF ++ DCN +   V+DP+    + VNF  + EE D  Q NEII QF+A +R  +V   S    SV+FTFQ YRFP +ST RL L ++        +  P +L      G  +   PG  +KY+LDP F+KPGE   F+ YL   TLH+DVWD +SLLLIGS AV+L++L RQG+ +VQ   EL++I+     D                 E S+ + GRLH+R+ N+G   ++ +++   L     P +  ++ A                           D T G  G S           KN   ++ L++T S      HS+  E+   ++      D IR       +KL+R    +R+ E E +    +  +  +R ++V+    LQ I+ YRE+ K E I   L+  I  + ++Y   G  E FE  +KN FN+   ++IE  D    V I +++E R  K +    T  E+D+ +        Q+++R  E+V IPFKY         +   P       S+ V    +  +V  +  ++ FR  + K L++ +V V P P +IDQTFRF+ PE SFL++ IR+PP H +            ++  RC+D +++ +      G P D+ LKV  GPSPQ+++F + +Y D +L  P+Q+W   VHS  R+DV    GQ T ++L+L+G      V+ +TSHP E+ + P E   F L  +   +L + + P + G++  ++NVVD+E H L+ SW++C +CK+P ISK FE+ LP+GGG+   K+I + NPYP Q+ F+L T+RPDL+  K+      A +V  IG+ F P      ++I +FIND+  KNEETF + V YQ
Sbjct:   13 EKSQVIPPHCQRTRLAQENSEGFQIILQHLEGMPVRQRLLEGLQGVQYQLRVSLFDITHRHVFGRTWRSSEQQMKTPQGQPYRVSFNEVLYFHTSLRHPSVVAIVEVVAVVPKADSSHQALG-CGFGILRLFSSQTEPGETSAAKQDKRLNLYHGTPRVLLHPALHDPFEQNSYVKVIQGAHVRYSLQSHPAMETIMHLLPQNILVSRTEDIPGVAPASDNSGDC-LRKPRLLKSFTCYLDKLSVILHPSTEKFEEDLLQLLNIDRLNRENSG--PDGNEVVVLERRLHVGIHNGWGFLHRPQVVVL---DPEPEEARGGTGSFRGRQGSLTKLSSSVRHALVLRSYLPLKGMVNHPAFSIVFQLEYVFSAPVGGEGKASSTTLFSHTAFMQCLRWAVWSPFVEPGSGANSE---VSLALQGGSEPNPSGVMVYRAPSTGMSSAEMEEVEGGTLRFRFSVRT-----------DGREPSPIRSV---------GSGLDEVSRQR-----KPPSPSRRRSASQPHTSPPRSPQGSGMSMSRISMSPRYPTISHSTASPWQQQIPCQLLPSPIAAAYQLSHA--------ELPFASSIAHLEADLSL---PAPQPQSPSAEQLQELPFTP-VHAPIVALGTQMPSAQ---ISRGALALLHSVGFPDVRDCNSQVAEVVDPS----DPVNFDPQREEADFFQYNEIILQFLAFSRVPEVGVKSDWPHSVYFTFQLYRFPPVSTQRLQLLDVDGSQRTSREPAPCVLAVINKDGIINSESPGLQLKYLLDPGFLKPGEKQWFLRYLAIHTLHIDVWDAESLLLIGSSAVELKHLLRQGRPAVQVMHELEVITTDYFQDSMALSSNISQHGSIKPIEVSTVVRGRLHLRLGNIGHHVNLKARRTGTLP----PSQSRVVSA--------------------------HDGTSGFAGGSLSSKSLCSLNVKNSSRAQRLVDTDSELAALLHSRMKEASIALRHADPELDEIR------QRKLERMME-VRRYEREGQISETKPYTMTRREERVQHSQDLQIIEAYRERSKVESITNMLSKAITIQHIVYATLGTAEFFEFALKNPFNVQQTITIECEDKELSV-IVDSREWRHFKDLTKTLTPLEDDMFHLQENTLKLQVYLRPNETVHIPFKYQTFTADHTATMQGPTDARLNRSANVTQNQQAKTVQPKIIKVTFRAEDSKPLALCQVNVEPTPHVIDQTFRFYQPELSFLKKSIRLPPWHTVPGLTVGGQGGEPQVYVRCSDPNIICDTKKMAPGEPQDVFLKVAVGPSPQIKKFFVMIYTDPWLAVPVQIWQLYVHSLQRVDVSCLTGQLTGLSLVLRGTQAVRKVKCYTSHPHELQIDPAE--VFVLPPNAVQDLQIGVRPQRAGSKFIYLNVVDVEFHQLVASWLVCVSCKQPFISKAFEISLPVGGGKGSNKKITYTNPYPSQRAFFLHTNRPDLLQFKEDTFETGAGEVYTIGLRFAPSQSAGVEEILIFINDQQDKNEETFCVKVVYQ 1449

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BLAST of NPHP4 vs. TrEMBL
Match: A0A2T7PTM2 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_03764 PE=4 SV=1)

HSP 1 Score: 573.933 bits (1478), Expect = 6.790e-176
Identity = 438/1443 (30.35%), Postives = 690/1443 (47.82%), Query Frame = 1

Query:  307 YFYTAFMDEYLSVIFEIIRYKTEDN----QTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----------NVQDPQXXXXXXXXXXXXXKHE---------------EHNCLTAKNSIEIS-MPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK-PDSVLR-----KIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESR-TLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPP--ILSVPF-----PNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENS-----------------SKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDA-----SQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIV-FRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASH---NEAIK-ILSRCTDSDVLSEC-PLKPIGTPHDIQLKV-PCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            YF+T+  +  + ++ E+I +    +    +   GW +         + D        T+ + +Y GT RAL  +    E++  +K   +  L  S+  HKA      L+PE  +V  + ++ G+E D      F+ P+L +  ++ ++ + V ++P+L  FE+EL E ++ DR  R+ +S  + ++ + +VERRL VGVHNG  + +   T  L              D Q R T++       ++                  + L  K+ I ++ +  D  F +VF LEY I+E +    RK    ++     T  VRW  + PF   +         + +  +GG+  AP++  VYK PD+ ++     KI  G   F        + + V       +   SH   +S   +      ++I +  SR +LS   KP + K +  +       E+V  + +   Q+  + A     MM  +T  Q         I  PP    L+ PF     P   + M Y  Q        +       + D  FT  V Q  + FP  ++S    GLSRA Y+Q+Y+AGF  ILD NGE P ++DPN       +  L ++   Q                        +VFF+FQFYR+P ++T+RL+L     Q+ +     P IL+K +  G+    PPG  +KY LDP FMKPGE+  F+ +L +Q LH+DVWDGDSLLLIGSC+V ++ LCR G  +VQ++FELD++     +D                     K  G+LH+R+AN+G  P        +   P K  +I +     S  +G    +L         R                  V R QP        S L+  +   +  E   PV          R ++ +  ++L R K    +L     ++  Q L   K+ +K E+    +T++ YR Q K E I   L+  I  E  I+P F   E FE  ++N +N D  ++I+  D    V +T+ +E R  K    + T  E  + +  +  +  Q+F+R KE+V IPFKY        + F    +S     P     +  E  +V F T + + +++L+++V PQP IIDQTFRF HPE SFL++ IR+PP H +        AI+ I +RC+D +V+ +C P++P G PHDI LKV   GPSPQ+++F + +YID FL  PIQVW   VH+  R+D+   +GQ++ + LLLKG   T  V+ ++SHP E+ ++P E   F L+A               G++ + +NVVDIE H L+RSW++C +C+ P +S+ F + LP+GGG+ C KRI + NPYP +K F + TDRPDL+  K+ +L +E    + IG+ F P+      ++ VFINDE+ KNEETF +   Y+
Sbjct:   80 YFHTSLCNTSIILVVEVIAHTIAPDGNPRKVGCGWSIIRPFTGDGNLPDASRGMAPPTLKVEMYHGTPRALLFMDEPIEANQLLKPIASCHLIYSVGSHKAMLTIIHLLPENVIVGNNTVVPGIE-DKPNEDRFQKPQLRQQVSFGLDGLVVHLQPNLERFEEELCELLSEDRANRENRS--QGSTRIAVVERRLHVGVHNGWTFTDKPQTFHLEPLAGSSIDSITGDDSQRRPTASPSFRRAIQYHIRRNSQPLTESGRNTGSSALVLKSQIHLTEVIEDPMFAVVFQLEYVISESLSDVDRKVSHSLARAHTRTISVRWTAWNPFLHSSTP------EISVALTGGTKRAPDDSFVYKLPDTEMQDLTAAKIAGGILAFRWTRGAKGEYLTV------PQISFSHGSMLS---IHSSEANEDIILDASRMSLSSGHKPPSGKPRTPR-------ESVAQQQMMQQQQQMLAAAG---MMYPQTGVQ--------GIMYPPAGMPLAYPFAGFGPPPISMQMAYAPQ-------AFREGPVSEMRDLPFTQ-VHQPVVTFPPPVQSK---GLSRAAYAQLYSAGFPLILDRNGEPPEILDPNIPP----SVNLAKKKSLQTGP--------------------GTVFFSFQFYRYPQVTTERLLLSQPASQLVSNTSNMPFILQKLDRDGSLLKGPPGLEVKYYLDPLFMKPGEVSMFLSHLTRQVLHIDVWDGDSLLLIGSCSVDMKYLCRGGNEAVQATFELDVVVSDQTEDSTGLTGDLQRGGSVRPVSTQHKTCGKLHLRIANIGH-PVDNRKAADMQPIPSKSQVIVSQTAANSAFKGGKSGTLPPPAGTKKAR------------------VARAQPLSDIGEVASLLLSNQKRKEAQEDTEPV----------RESDAERHRRLARMKALKAEL---TRSLRRQPLYYYKK-EKTERIRDFKTLEIYRHQTKHEGILTMLSQNITTEHAIFPSFATAEFFEFVLRNPYNQDQCLTIQWEDKDLRV-VTDAREWRYFKQFCGLATPLEEGMFSTQSTSDTPQLFLRPKETVHIPFKY--------KVFRQTTLS----CPRSEGFLYFESGMVKFLTEDGRPMAVLKLQVEPQPHIIDQTFRFHHPENSFLKKSIRLPPFHNLPGAPVGGSAIRQIYTRCSDPNVILDCKPMQP-GDPHDIFLKVVALGPSPQIKRFFITIYIDPFLSLPIQVWQCYVHALQRVDINCIEGQTSQVALLLKGTQATRLVRCYSSHPSEMTLSPQE--PFVLAA---------------GSKFYFLNVVDIEYHQLVRSWLVCTSCRAPIVSRAFTLTLPVGGGKGCSKRITYTNPYPLRKTFKILTDRPDLLQFKENLLELEGGAAQPIGLRFAPVTHPGIAELLVFINDEEDKNEETFRITAEYK 1387

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BLAST of NPHP4 vs. TrEMBL
Match: A0A210PMI3 (Nephrocystin-4 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT21360 PE=4 SV=1)

HSP 1 Score: 575.859 bits (1483), Expect = 1.141e-175
Identity = 315/877 (35.92%), Postives = 495/877 (56.44%), Query Frame = 1

Query: 1885 GLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTR---FDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDEN-----------------SSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSP----------VRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAI----KILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            GLSRA Y++++ AGF+ ILD N E P VIDP Q +   ++   E  D  QCNEI+FQF+A ++   F+  G    TK+VFFTFQFYR P ++T+R++L    +++S+   + P IL+K +  G  +  PPG  ++Y +DPA MKPGE   F+++L QQ LH+DVWDGD+LLL+GSCAV+L+ LCR G  +VQ++FELD+I+    +D N                  + + G+LH+RMAN+G     K      I H  K   +  SQ  G                  Y    +TG    +++    P  +  K    ++ +  K+H   +  MS     +  +D  R  + ++ +KL R  + +RQ +  +  +N  +  + ++SD++      +TI+ YR Q K + I   L+  I     ++P FG +E FE   KN FN+   +++E +D    V +T+ +E R  K ++ +    E  + N  ++    +IF+R KE+V IPFKY  +   AD+S        P          ++ P      +   ++ F+  + K +SIL V V PQP IIDQTFRF+HPEQSFL++ IRMPP   +           ++  RC++S V+ +      G P D+ LKV  GPSPQ ++F +A+Y D F+ +P+Q+W F VH+  R+DV   +GQ++   LLL+G   +  V+ ++SHP E+ + P   + F L+A   +E+++ + P+K GN+ F++N+VD+E H LIRSW++C TC+ P +S+ F++ LP+GGG+ C KRI + NPYP++K F L  +R DL+  +++ L IE  + + IG+ F P+ +    ++ VFINDED KNEETF +   YQ
Sbjct:  658 GLSRAAYARLFNAGFEPILDRNSEPPEVIDPRQQRR--LDLSKENSDPLQCNEIVFQFLAFSKMMTFEATGPKTETKTVFFTFQFYRCPQVTTERMMLAKPENELSSDRYSVPYILQKIQPDGNMTQAPPGMEVRYHMDPACMKPGENALFLKHLFQQVLHIDVWDGDTLLLMGSCAVQLKYLCRCGSEAVQTTFELDVITTEYENDPNIVNSNINQVGGLQAFGVKTYVKGKLHLRMANIGQKTDPKSTLAAQIGHTGKKPRV-LSQTAG---------------NSSYPGGGLTGT---FTSSSATPGESQLKKVARAKHVADKNHEVQAMLMSHKDQMVPEKDTNREGDAEKNRKLSRI-HAVRQAQGIDNKVNTIMSYKTEKSDRMRD---YKTIEIYRLQTKKDGIMSMLSQTISTNYTVHPSFGSSEFFEYVFKNPFNVQQTITVEFDDKELHV-VTDPREWRYFKRLYELQGEVEEGMFNKQSKAQYVEIFLRPKETVQIPFKY--LTFTADESVQPQGPVDPFKQKNEDDEDIKKPPSQTMNEKSIKVYFKNEDGKPVSILNVNVEPQPHIIDQTFRFYHPEQSFLKKSIRMPPFQSLPGAPVGGPGLNQVFVRCSNSHVICDSKSTQPGEPTDVFLKVAMGPSPQSKRFFVAMYFDPFMARPVQIWQFYVHALQRVDVACVEGQTSRFDLLLRGTQASRLVRCYSSHPNEMQMFP--GDQFMLTAGAVHEMTVAVRPMKEGNKFFYINIVDVEYHQLIRSWLVCVTCRPPMVSRSFDVVLPMGGGKGCSKRIPYTNPYPHKKVFVLLNNREDLLQFRESRLEIEGGETQTIGLRFTPVTKAGSVEVMVFINDEDDKNEETFKITATYQ 1504

HSP 2 Score: 164.081 bits (414), Expect = 1.002e-36
Identity = 130/440 (29.55%), Postives = 218/440 (49.55%), Query Frame = 1

Query:   49 EKHKYIPPPKERQGNTKADNLSFCIKLLDLD-LSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIR-YKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETI---SIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGL-EVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNV-QD----------PQXXXXXXXXXXXXXKHEEHNCLTAKNSIEIS-MPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYK-PDSVLR 1311
            EK+ ++PP + R+      +   CI L  ++ L  R    T E   +  SL+D N++ FFG+QW      ++N +     ++ NQ +YF+T+  +  L+ + E +   + ED +     C + L++  K   DL    ++  +    I ++ GT RALF ++   ESD  +K   +  L  ++  HKA      LIPE  +V  +D+I GL E    G    + P+  +     +E V + + P++ +FE+EL E ++ DR+ERDG++     + + IVERRL VGVHNG  +++      L++ QD          P +RR+   + SS    +    LT +N IE+  +  D    I F LEY I EP+  + RK    ++     T  +RW  + PF  +++      IRL L+  GG   AP+   +YK PD+ ++
Sbjct:   16 EKNNHLPPAENREQAAPEISTPICISLTGIEGLFVRNESKTVE-YQLSISLYDLNFRHFFGRQW-IGPYTSMNANQKKPKLKYNQNVYFHTSLGNASLAGVVEAVATVREEDGKQKKSTCAWGLIRIFKSNEDLPDFGRASNLPVQKIQMFYGTPRALFFMEEPIESDSNLKPIPDCVLSYTLGTHKALLDVMNLIPENVIVASNDMIPGLQESQTPGKDQLKKPKSMRKIACQLEHVNIQLLPTVDKFEEELSELLHKDRVERDGRA--TSGTQVTIVERRLLVGVHNGWGFLDKPQIFHLDLHQDKSKSLKPTASPSVRRSKKFQQSSQKTEDSTTFLTLQNKIELGELLEDPMVAITFTLEYVIGEPLSEEDRKVSSCVARGNTRTVSIRWAAWNPFLAQSSYE----IRLALN--GGPSPAPDEEFIYKLPDTKMQ 445

[Close]

BLAST of NPHP4 vs. TrEMBL
Match: A0A4W3GM71 (Uncharacterized protein OS=Callorhinchus milii OX=7868 GN=nphp4 PE=4 SV=1)

HSP 1 Score: 567.385 bits (1461), Expect = 1.041e-173
Identity = 435/1470 (29.59%), Postives = 704/1470 (47.89%), Query Frame = 1

Query:  175 NIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRY-KTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL--NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEIS-MPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSV------LRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSM-------VQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLIL--DNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDII-------SPV---DIDDENSSK-------LSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDII--RGTNHDEAKKLKRFKNTL--RQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVR---TPH---KLASVDL---EYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHM-----IASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            N  ++ +LFD +Y  FFG+   SS     +       +  N+ +Y  T     ++ +I E++ + K  D    +  C F +L             + +   + +Y GT RAL   +LK   E +  +   E S +   +  H A +    L+PE  L+   + I G+     G  D  + PR+ K   + ++++ + + P+L +FE+EL+E +N DRL ++ +S   D +++ I ERRL+VGVHNG  +++      +  ++       +  R  S  S   E+  L  ++ I+++ M +   F +VF LEY  + P  +DG+ +         + + +RW V+ P  +    T      + L   GGS+  P N LVYK  S       +R++E G   F                       PS S  +S   VA    E+ ++         P  P       + S    L E+ +   +   Q A    Y       + TL++    Q+S              P  M ++ YT   G  +             ++GF  +       V    +A   Q RS   +  SRA  +Q+   GF EILD N E   V+DP QD  N+ N + EE D+ QCNEII QF+A TR  +  +S   + ++F+FQFYRFP + T +L L     ++   N     P+IL      G+ +   PG  +KYM++P+F+K GE   FI YL  QTL +DVWD +SLLL+GS AV+L++L RQ + +VQ + EL++I       +P+   D+    + K         GRLH+R+ N+G V  ++ +  +L +   + +    S  EG                         GG L   N+ V       + + LS+L         SE  S +   L    I   +G N  +A + ++ +  L  RQ E+ N   + +     +R ++++    LQ I+ YREQ K   I   L+  I  +  +Y   G  E FE  +KN  N+   ++IE       + I N++E R  K++ +  T  E D+          Q+++R KE+V IPFK+   +  AD  +  P   S +R   TP+   +L S  L   + ++ F+T + K ++IL+V V  QP +IDQTFRF+HPE +FL++ IR+PP H      + +  + ++I  RC+DS+++ E        P D+ LKV CGPSPQ+ +F + +Y+D +L  PIQ+W F +HS +R+DV    GQ + ++L+L+G      V  +TSHP E+ + P  + +F L  H+  +L L L P + GNR  ++NVVDIE   L+ SW++   C +P ISK FE+ +P+  G+   KRI + N YP ++ F+L T+R DL+  K+    +   +  +IG+ F P      ++I +FIND++ KNE TF + V YQ
Sbjct:    5 NYQLRLNLFDTSYSHFFGRTLKSSARPLKSAPGQPAKVLFNEAVYLQTFLNYTHIVIIVEVVAFVKKRDGTQNVLSCGFGILPLNSRQQPTSDTTQPQVKRLNLYHGTPRALLHPELKDPIEKNRLMTLIEGSHILYLLRTHPALEKVMHLVPENMLISGVETIPGIVQPYGGTNDALKKPRILKSTIFHLDELSIQLYPTLEKFEEELVELLNADRLNKNNQS--TDGNTIIIQERRLQVGVHNGWCFVQKPQVTVVIPSITMRGKSGSLRRSFSHRSLSGENESLILRSRIQLTEMVHHPAFAVVFQLEYVFSVPTITDGKANTATSFSETAYMHTIRWAVWNPPLKAATST------VTLPLHGGSLANPNNLLVYKVPSTAMSSLEVRQVESGTISFRF-------------------DCPSKSQALSSEEVATTGPEEPLR---------PTTPIESHLGTSISDVAGLQESPQGPGLSLSQLALSSRYLSISHSDRITLQEHFSSQLS--------------PFSMTSVQYT---GIPESPISRTRGTDTAAEQGFDQLRELPFTPVHAPVIALGTQTRSSRSV-TSRAALAQMRTVGFPEILDDNKELAEVLDP-QDAANL-NLQKEEADYLQCNEIILQFLAFTR--IPQDSLWPRLIYFSFQFYRFPPVITRQLQLVKAGSVEASGNM----PLILIPVNKDGSINTASPGLELKYMVEPSFLKQGEQRWFIRYLAMQTLQIDVWDAESLLLMGSAAVELKHLLRQTRSAVQVTHELEVITTEFSQDAPMPSGDLTRHGAVKPFGVTTLTKGRLHMRLGNIGHVSEQRKSSHSLPSSHSRVI----SSHEG--------------------PSGFPGGSLSNQNVKVLKAHNTFRAQRLSDL--------DSELASLLVTRLKESSISVQQGRNEMDAVRQRKLERMLAVRQFESSNSASSSRSHILGRREERIQHTRDLQIIEAYREQTKTASIVNMLHQAITTQYTMYATLGTAEFFEFSLKNPHNVQHTITIECEHPELSI-IINSREWRHFKNLTNTLTPLEEDMFLVQGGIIFPQVYLRPKETVHIPFKFQTFS--ADH-YVPPQGPSDLRLCKTPNVGNQLESNTLSAKKIRVHFKTEDGKPIAILQVNVESQPYVIDQTFRFYHPEFTFLKKSIRLPPWHTMPGTHVQTQTDELQINVRCSDSNIICETKKMDRNEPQDVFLKVSCGPSPQINKFFIMVYMDLWLATPIQIWQFYIHSLNRVDVSCVMGQLSQLSLVLRGTQAVRTVAAYTSHPHELQIEP--SGAFVLPPHSVKDLHLTLRPQRDGNRCIYLNVVDIEYRQLVASWLMYVACGQPFISKAFEVTIPVREGKGSTKRISYTNLYPTKRVFFLRTNRADLLRYKEDYFEVGGGETYSIGLRFAPGQAPGVEEILIFINDQEEKNEATFCVKVTYQ 1374

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BLAST of NPHP4 vs. Ensembl Cavefish
Match: ENSAMXT00000022163.2 (pep primary_assembly:Astyanax_mexicanus-2.0:6:983911:1031636:-1 gene:ENSAMXG00000021522.2 transcript:ENSAMXT00000022163.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 289.271 bits (739), Expect = 1.480e-85
Identity = 159/479 (33.19%), Postives = 248/479 (51.77%), Query Frame = 1

Query: 2977 KRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            ++ D+ +    L+ IQ YRE+ K E I   L   +  +  +Y   G  E  E  +KN FN+   ++IE +D    V +   +E R  K +  + T  E ++ +   + +  Q+++R KESV IP KY      +    AS  +                 Q+ FR  + + L+I +V V P P ++DQTFRF+HPE +FL++ IR+PP           +  +           P    G P DI LKVP   SPQ+R+F + ++ D +L  P Q W   VH   R+DVV   G  +  +L+L+G      VQ +TSHP E+ V P     F+L A    +L L +  ++ GN   ++NVVD+++  L+ SW++C  CK+P IS+ FE+Q+P+GGG+   K+  F NPYP+ K F L +D PDL+        I+  +  +IG+ F P      ++I +FIND + KNEET+ + V Y+
Sbjct:   20 RKQDRAQHSQDLRLIQAYRERCKAESITSMLTQALTTKHTLYATLGTAEFLEFLLKNPFNVPQTITIECDDPELSV-VVKAEEWRYFKDLVKVCTPMEEEMFHLQEKSSAPQLYLRPKESVYIPLKYQTFTSSSTSPPASTRLGVS--------------QVFFRAEDGQPLAICQVNVEPTPHVVDQTFRFYHPELTFLKKAIRLPPATDSPPGAAHYQPHTHTHTRTHTHPDP----GEPQDIYLKVPGSSSPQIRKFFITVFTDPWLASPAQTWQVYVHYLQRMDVVCVCGTLSWHSLILRGTQTIRKVQCYTSHPLELQVDP--GGVFALPAQGLQDLRLGVRALRSGNSFRYLNVVDVDTRQLVTSWLLCINCKQPLISRAFEIQVPVGGGRGSNKKFSFTNPYPFSKGFRLYSDHPDLLQFNKEDFQIKGGESYSIGLRFAPSQSPGTEEILIFINDLEDKNEETYCVKVVYR 477

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BLAST of NPHP4 vs. Ensembl Cavefish
Match: nphp4 (nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-060503-715])

HSP 1 Score: 77.7962 bits (190), Expect = 8.039e-15
Identity = 71/282 (25.18%), Postives = 116/282 (41.13%), Query Frame = 1

Query:   10 TLIFRKMDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNE-----NIYIKASLFDFNYQSFFGKQWDSSTMENL--NKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEII----RYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQ--LKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDR 813
            T   +  D R + E  + +PP  +      A   S   +L+ L     L P  +E     +  ++ SLFD  +Q FFG+ W S    +   N+H    T+Q N+ +YF+T      +  + E++    R  +  N T  G+ +  L          H   +     + +Y GT R L    L+   + +  +   E + L  S+  H A      LIP   L+     I G+    +   D    PRL      ++E+V V + PS   FE +LL+ +N DR
Sbjct:    3 TAELQASDWRGIFEGRRAVPPHSQSSRLAAAAGQSQAFRLV-LKQVDGLQPKQSEEGKASDYQLRVSLFDSEHQHFFGRTWKSEPHPSRLSNRHT---TVQFNEVVYFHTPLCWSSVVAVVELVSLSSRTDSSQNATGAGFGLMQLFSRGPDSEPPHGEGR-----LSLYHGTPRVLLHPSLRDPLQMNAVLSVMEGTQLLYSLQPHPALTPAMHLIPPNILLSAHHPIPGVLPPTDSTADALRRPRLLPDVPCALERVDVSLAPSTEVFEADLLQMLNYDR 275

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BLAST of NPHP4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002494.1 (pep scaffold:Pmarinus_7.0:GL480100:17735:27439:-1 gene:ENSPMAG00000002277.1 transcript:ENSPMAT00000002494.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 129.413 bits (324), Expect = 1.114e-34
Identity = 61/161 (37.89%), Postives = 93/161 (57.76%), Query Frame = 1

Query: 3931 PEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            P  + V+P   + F+L   + +E+SL + P+  G R   ++ VD ES T++  W++CA+C  P IS+ FE +LP GG +   KRI + NPY   ++  L   RPDLV+ K+ I  + A    +IG+ FVP   R  + I +FIN+ +G NEET  + V Y 
Sbjct:    1 PRPLQVSP--RDEFTLQPDSVHEVSLRVRPLSAGTRSHLLSAVDTESLTMLNCWLVCASCSPPVISREFEFRLPAGGAKGSSKRIKYTNPYGEARKLELQASRPDLVIFKEDIFEVAARGEYSIGLRFVPGAARGTESILIFINNTEGDNEETLCVRVTYD 159

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BLAST of NPHP4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007242.1 (pep scaffold:Pmarinus_7.0:GL477828:60629:68621:1 gene:ENSPMAG00000006544.1 transcript:ENSPMAT00000007242.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 76.2554 bits (186), Expect = 9.126e-17
Identity = 42/110 (38.18%), Postives = 65/110 (59.09%), Query Frame = 1

Query: 3457 QIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMI--ASHNEAI---KILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALY 3771
            Q+ FRT +D  ++IL+V V PQPP++++ FRF  PE + L++ IR+P  H    AS  EA    ++  RC+D+++L +        P DI +KV   PSP V  F + +Y
Sbjct:    1 QVFFRTPDDLPIAILQVDVEPQPPLVNEMFRFCQPELTILKKTIRLPAWHSFSGASRAEARAEQQLHVRCSDANILCKTSNSGASEPCDIFVKVSGSPSPHVTAFFVMIY 110

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BLAST of NPHP4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003405.1 (pep scaffold:Pmarinus_7.0:GL480964:6714:22420:1 gene:ENSPMAG00000003116.1 transcript:ENSPMAT00000003405.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 59.6918 bits (143), Expect = 1.152e-10
Identity = 37/104 (35.58%), Postives = 55/104 (52.88%), Query Frame = 1

Query:  616 LIPEYFLVHEDDIISGLEVD--NEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIED 918
            L+PE   +    I+ GL     N   CD    PRL K     ++ + V + PSL  FE+ LL  +N DRL  D +  + D  ++ + ERRL +GVHNG  +++D
Sbjct:   35 LLPENCPLPGSAIVPGLASAPANSDSCDALLKPRLLKSSPCYLDHITVTLPPSLERFEETLLSLLNQDRLNADDR--MPDGHAVAVQERRLHIGVHNGWTFVQD 136

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BLAST of NPHP4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003407.1 (pep scaffold:Pmarinus_7.0:GL480964:6774:22456:1 gene:ENSPMAG00000003116.1 transcript:ENSPMAT00000003407.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 57.7658 bits (138), Expect = 5.429e-10
Identity = 28/72 (38.89%), Postives = 43/72 (59.72%), Query Frame = 1

Query:  703 PRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIED 918
            PRL K     ++ + V + PSL  FE+ LL  +N DRL  D +  + D  ++ + ERRL +GVHNG  +++D
Sbjct:   45 PRLLKSSPCYLDHITVTLPPSLERFEETLLSLLNQDRLNADDR--MPDGHAVAVQERRLHIGVHNGWTFVQD 114

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BLAST of NPHP4 vs. Ensembl Nematostella
Match: EDO41800 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S371])

HSP 1 Score: 236.884 bits (603), Expect = 4.667e-64
Identity = 109/239 (45.61%), Postives = 162/239 (67.78%), Query Frame = 1

Query: 3700 PHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKF-HVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            P D+ LKV CGPSP V++F L L+ID F+  P Q W F VHS  R+D+ A +GQ++ ++++L+G  ++  VQ FTSH EE+ V P  ++ F L A+  +E+SL+LTP+  G  ++ +VNVVD E H L+R+W++CATC++P ISK FE+QL +GGG+   KR+ F NPYP +K F+L ++RPDL+  K+  + +      NIG+ F P       +I +FIND +GKNEETF++   Y+
Sbjct:  747 PQDVFLKVACGPSPSVKRFFLLLFIDPFMATPCQTWQFYVHSLQRVDISAVEGQTSQLSVILRGTQSSRLVQCFTSHAEELQVRP--SDPFMLMANGVHEISLSLTPLTSGGTRYMYVNVVDNEFHQLVRTWLVCATCQQPVISKAFELQLQVGGGKGSNKRVTFTNPYPTRKAFHLKSNRPDLLQFKEDTIEVGPGASHNIGLRFSPQPAPAVTQILIFINDSEGKNEETFSITAVYK 983

HSP 2 Score: 174.096 bits (440), Expect = 4.735e-44
Identity = 103/244 (42.21%), Postives = 143/244 (58.61%), Query Frame = 1

Query: 1870 SHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIIS----------PVDIDDENS-------SKLSGRLHIRMANLG 2550
            S  G  L+RA Y+++  AG+  I D +G  P VIDP +     +N + E  D  Q NEI+  F+AL R    G+    +SVFFTFQFYRFP ++T+RL L N      N  +    +L+K    G+ S   PG ++KY++DPAFM+ GE   F  YL  QT+H+DVWDGDSLLLIGS A++L++L RQG+ +V  S E+DI+S          P D+    +       + + G LHIRMAN+G
Sbjct:  408 SSRGSTLTRADYARLSRAGYPPITDRHGNPPLVIDPAEYVP--LNLDNENMDSLQANEIVLHFLALNR--CYGH----RSVFFTFQFYRFPQVTTERLFLKNS----DNQSQGDLCVLQKFNKDGSLSNEAPGLLLKYLVDPAFMQRGENRVFCRYLLSQTIHMDVWDGDSLLLIGSLAIELKHLLRQGREAVLVSHEVDIVSVEFSEDAPAMPGDVTRTGTVRPVGMRAGVEGALHIRMANIG 639

HSP 3 Score: 88.1965 bits (217), Expect = 1.638e-17
Identity = 76/249 (30.52%), Postives = 112/249 (44.98%), Query Frame = 1

Query:  577 SINIHKAFDVCHTLIPEYFLVHEDDIISG-LEV--DNEGFCD-FENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL----NVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEI-SMPNDQEFTIVFILEYSIAEPVY--------------------SDGRKDIGIMSPLPQ-------------HTYQVRWIVYQPFA 1197
            S+  H   +    LIPE  L+  DDI+ G LE+  ++ GF D  + PRL K     I K+ V  +PS+ EFE+ LL ++N DRL RD  S   D   + IVERRLRV VHNG  ++ +   ++L     V   +  R S   P +     +   L  ++ +E+  +     F +VF +EY I+EP                      S GR  +  ++P  +              T  VRW V+ PF 
Sbjct:    4 SLQTHNVLEKALHLIPENALLGGDDIVPGILEIVQEDSGFVDILKKPRLMKTNPCFINKLTVDFQPSVNEFEENLLHDLNMDRLHRDNIS-PDDGLKISIVERRLRVCVHNGWTFVSEPHMVYLEPEFEVGGSKSGRKSPITPQTSLTGSKIASLVLRSRLELRELVRHPLFAVVFEVEYVISEPYAQPLINPKKKKVTLNHAIVHNSRGRSGVWFINPKKKKASLSGSLLRSQNQTITVRWAVWTPFG 251

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BLAST of NPHP4 vs. Ensembl Medaka
Match: ENSORLT00000040456.1 (nephrocystin 4 [Source:NCBI gene;Acc:101155253])

HSP 1 Score: 379.793 bits (974), Expect = 4.447e-109
Identity = 250/860 (29.07%), Postives = 406/860 (47.21%), Query Frame = 1

Query: 1909 QIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDV-NGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLS-------------------GRLHIRMANLGSVPSKKYNGLTLIAH-PKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRT-------PHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMP--PLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFAL 4398
             +++  F E++D  G+   V+DP +    + + + E+ D  Q N ++FQF+ALTR    + +     ++F TFQFYRFP +++ RL L +     S+  +  P IL      G  +   PG  +++ +D  F++PGE   F+ YL   T+H+DVWDGDSLLLIGS A++L+ L RQG+ +VQ+  EL++++  D   E++S LS                   GRL++R +N GS      +  T + H P    II   +                            GG L     +   QP+     E+  L    +  + + S +P      + +  R  +   A + +     ++ L  E +   +                 L ++Q   E++K E+I   L   I    ++Y   G  E  E  +KN F++  +VSI  +D    V ITN +E R  K      T    ++ + +       +++R KESV IP KY +   Q+      P      +T       P K+ +     Q+ F     + L+IL ++V P P ++ QTFR +HPE  FL++ IR+P  P    A    A+    RC+D D++ +      G P  + LKVP  PSP +R F + L++D ++  P Q+W   VH   R+DV    GQ     ++L+G    H V+ F SHP E+ V P     F L      EL L L P + G R  +VN V+ E H L+ +W++C +   P +SK FE+ +P+G G+   KR+ ++NPY  ++ F L +DRPDL+  ++    ++  +   IG+ F P       +I V++N+ +   EETF +
Sbjct:  606 HLFSVSFPEVVDHRGQKAEVLDPKEPL--LFDPQREDADFLQDNLLVFQFLALTRTSAADADPGWPSNIFITFQFYRFPPVASQRLRLLS-----SDGAEGLPCILATVGKDGTVNSASPGLQLQFKVDDRFLRPGEKRRFLGYLALHTMHLDVWDGDSLLLIGSTAIELKYLLRQGRPAVQALHELEVLT-TDYAGEDTSLLSTDPGHRSTYGPATFRTIVRGRLYVRTSNFGS--GTDGSRQTAVDHRPSAAHIITPCRANC----------------------GFRGGRLFPRQFL---QPSGRNTMEVDRLDGHAASGRTAASAAP-----EDSETCRKLHCMAAVRRREEAAKMQDLSQEGQPTGE-----------------LPSVQLSAERRKAEMITAMLRENITTLHLLYASLGSAEFMEFVLKNPFDVPQSVSIHSDDPELSV-ITNAEEWRYYKETTQTPTPLLENMFHMEGGAEGPMVYLRPKESVHIPLKYQSFFCQSATVLQGPGFLPTSQTSQMAKKNPSKIPAAK-TIQVTFLAEGGRPLAILHLRVEPTPHLVHQTFRLYHPELGFLKKAIRLPLDPAAGQADGGTAV----RCSDPDIICQTRTLVPGGPQHVFLKVPGSPSPDIRLFFVMLFVDAWMAAPSQIWQIFVHFLERVDVSCVTGQQHCQAVILRGRKAVHTVRCFPSHPRELQVDPA--GVFVLPPGAVQELQLKLQPWQAGRRFMYVNAVEGEQHGLLAAWLLCLSIHRPVLSKAFELCIPVGSGRGSSKRMTYRNPYSSRRTFLLHSDRPDLLQFREERFEVDGGESHAIGLRFAPTQTPGSAEILVYVNNLEEATEETFCV 1400

HSP 2 Score: 105.145 bits (261), Expect = 4.002e-22
Identity = 106/433 (24.48%), Postives = 186/433 (42.96%), Query Frame = 1

Query:   55 HKYIPPPKERQGNTKADNLSFC--IKLLDLDLSSRLVP------DTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQT----CIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----NVQDP-QXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ-VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            H+++PP   +     AD+ S     +L  + +S+  +P      + + +  ++A+LFD N   FFG+ W SS  +  N+      +  NQ +YF+T+ +   + V+ E++   T+ + +      G+ V  LL        ++  ++     + ++ GT R L   QL+   +    +K  + + L + +  H +      L+P+  +V  D+ I G E    G      P+L +    S+ ++ V ++PSL  FE  LL+ IN D L            S+ I ERRL VGVHNG  ++E    + L      V+ P       ++     S     +  ++     +  PN     IVF LEY+ + P   +    +   S       Q +RW  + PF Q+      +   ++L   GGS   P   LVY
Sbjct:   21 HRFVPP-SGQTARAAADSFSQSRGFQLGPMRISAPHLPQEMFAGEPDASFQLRATLFDRNQLLFFGRTWKSSAQKMKNQ-----KISFNQVLYFHTSLLVPGILVVLELVSISTKRDGSHQAVGRGFAVLELLSSGPQAPPVYGERR-----LNLHHGTPRGLLHPQLRDAADYSSYLKPIDGAHLDMELKNHPSLLSVAHLLPDNSIVSGDEDIPGPEPSPTGDA-LLRPQLPEMMPLSLNRLTVSLQPSLETFESRLLQLINADGLNMRQLGPEDAQKSVVIQERRLHVGVHNGWCFLEKPQVVVLERLASGVRGPTDGGAKRSKPVMDSSSSSTLSLRSSLQLWLVDHPN---IAIVFQLEYAFSAPTSIN--SALSATSTTRAAFLQCLRWGGWCPFQQQADWNSRE---IQLALQGGSKPNPFGVLVY 433

[Close]

BLAST of NPHP4 vs. Ensembl Medaka
Match: ENSORLT00000032624.1 (nephrocystin 4 [Source:NCBI gene;Acc:101155253])

HSP 1 Score: 379.022 bits (972), Expect = 8.864e-109
Identity = 250/860 (29.07%), Postives = 405/860 (47.09%), Query Frame = 1

Query: 1909 QIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDV-NGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLS-------------------GRLHIRMANLGSVPSKKYNGLTLIAH-PKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRT-------PHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMP--PLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFAL 4398
             +++  F E++D  G+   V+DP +    + + + E+ D  Q N ++FQF+ALTR    + +     ++F TFQFYRFP +++ RL L +     S+  +  P IL      G  +   PG  +++ +D  F++PGE   F+ YL   T+H+DVWDGDSLLLIGS A++L+ L RQG+ +VQ+  EL++++  D   E++S LS                   GRL++R +N GS         T + H P    II   +                            GG L     +   QP+     E+  L    +  + + S +P      + +  R  +   A + +     ++ L  E +   +                 L ++Q   E++K E+I   L   I    ++Y   G  E  E  +KN F++  +VSI  +D    V ITN +E R  K      T    ++ + +       +++R KESV IP KY +   Q+      P      +T       P K+ +     Q+ F     + L+IL ++V P P ++ QTFR +HPE  FL++ IR+P  P    A    A+    RC+D D++ +      G P  + LKVP  PSP +R F + L++D ++  P Q+W   VH   R+DV    GQ     ++L+G    H V+ F SHP E+ V P     F L      EL L L P + G R  +VN V+ E H L+ +W++C +   P +SK FE+ +P+G G+   KR+ ++NPY  ++ F L +DRPDL+  ++    ++  +   IG+ F P       +I V++N+ +   EETF +
Sbjct:  567 HLFSVSFPEVVDHRGQKAEVLDPKEPL--LFDPQREDADFLQDNLLVFQFLALTRTSAADADPGWPSNIFITFQFYRFPPVASQRLRLLS-----SDGAEGLPCILATVGKDGTVNSASPGLQLQFKVDDRFLRPGEKRRFLGYLALHTMHLDVWDGDSLLLIGSTAIELKYLLRQGRPAVQALHELEVLT-TDYAGEDTSLLSTDPGHRSTYGPATFRTIVRGRLYVRTSNFGSGTDGSRQ--TAVDHRPSAAHIITPCRANC----------------------GFRGGRLFPRQFL---QPSGRNTMEVDRLDGHAASGRTAASAAP-----EDSETCRKLHCMAAVRRREEAAKMQDLSQEGQPTGE-----------------LPSVQLSAERRKAEMITAMLRENITTLHLLYASLGSAEFMEFVLKNPFDVPQSVSIHSDDPELSV-ITNAEEWRYYKETTQTPTPLLENMFHMEGGAEGPMVYLRPKESVHIPLKYQSFFCQSATVLQGPGFLPTSQTSQMAKKNPSKIPAAK-TIQVTFLAEGGRPLAILHLRVEPTPHLVHQTFRLYHPELGFLKKAIRLPLDPAAGQADGGTAV----RCSDPDIICQTRTLVPGGPQHVFLKVPGSPSPDIRLFFVMLFVDAWMAAPSQIWQIFVHFLERVDVSCVTGQQHCQAVILRGRKAVHTVRCFPSHPRELQVDPA--GVFVLPPGAVQELQLKLQPWQAGRRFMYVNAVEGEQHGLLAAWLLCLSIHRPVLSKAFELCIPVGSGRGSSKRMTYRNPYSSRRTFLLHSDRPDLLQFREERFEVDGGESHAIGLRFAPTQTPGSAEILVYVNNLEEATEETFCV 1361

HSP 2 Score: 100.523 bits (249), Expect = 9.644e-21
Identity = 79/308 (25.65%), Postives = 142/308 (46.10%), Query Frame = 1

Query:   55 HKYIPPPKERQGNTKADNLS--FCIKLLDLDLSSRLVP------DTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQT----CIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL 936
            H+++PP   +     AD+ S     +L  + +S+  +P      + + +  ++A+LFD N   FFG+ W SS  +  N+      +  NQ +YF+T+ +   + V+ E++   T+ + +      G+ V  LL        ++  ++     + ++ GT R L   QL+   +    +K  + + L + +  H +      L+P+  +V  D+ I G E    G      P+L +    S+ ++ V ++PSL  FE  LL+ IN D L            S+ I ERRL VGVHNG  ++E    + L
Sbjct:   47 HRFVPP-SGQTARAAADSFSQSRGFQLGPMRISAPHLPQEMFAGEPDASFQLRATLFDRNQLLFFGRTWKSSAQKMKNQ-----KISFNQVLYFHTSLLVPGILVVLELVSISTKRDGSHQAVGRGFAVLELLSSGPQAPPVYGERR-----LNLHHGTPRGLLHPQLRDAADYSSYLKPIDGAHLDMELKNHPSLLSVAHLLPDNSIVSGDEDIPGPEPSPTGDA-LLRPQLPEMMPLSLNRLTVSLQPSLETFESRLLQLINADGLNMRQLGPEDAQKSVVIQERRLHVGVHNGWCFLEKPQVVVL 342

[Close]

BLAST of NPHP4 vs. Ensembl Medaka
Match: ENSORLT00000041622.1 (nephrocystin 4 [Source:NCBI gene;Acc:101155253])

HSP 1 Score: 379.407 bits (973), Expect = 1.130e-108
Identity = 250/860 (29.07%), Postives = 405/860 (47.09%), Query Frame = 1

Query: 1909 QIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDV-NGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLS-------------------GRLHIRMANLGSVPSKKYNGLTLIAH-PKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRT-------PHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMP--PLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFAL 4398
             +++  F E++D  G+   V+DP +    + + + E+ D  Q N ++FQF+ALTR    + +     ++F TFQFYRFP +++ RL L +     S+  +  P IL      G  +   PG  +++ +D  F++PGE   F+ YL   T+H+DVWDGDSLLLIGS A++L+ L RQG+ +VQ+  EL++++  D   E++S LS                   GRL++R +N GS         T + H P    II   +                            GG L     +   QP+     E+  L    +  + + S +P      + +  R  +   A + +     ++ L  E +   +                 L ++Q   E++K E+I   L   I    ++Y   G  E  E  +KN F++  +VSI  +D    V ITN +E R  K      T    ++ + +       +++R KESV IP KY +   Q+      P      +T       P K+ +     Q+ F     + L+IL ++V P P ++ QTFR +HPE  FL++ IR+P  P    A    A+    RC+D D++ +      G P  + LKVP  PSP +R F + L++D ++  P Q+W   VH   R+DV    GQ     ++L+G    H V+ F SHP E+ V P     F L      EL L L P + G R  +VN V+ E H L+ +W++C +   P +SK FE+ +P+G G+   KR+ ++NPY  ++ F L +DRPDL+  ++    ++  +   IG+ F P       +I V++N+ +   EETF +
Sbjct:  632 HLFSVSFPEVVDHRGQKAEVLDPKEPL--LFDPQREDADFLQDNLLVFQFLALTRTSAADADPGWPSNIFITFQFYRFPPVASQRLRLLS-----SDGAEGLPCILATVGKDGTVNSASPGLQLQFKVDDRFLRPGEKRRFLGYLALHTMHLDVWDGDSLLLIGSTAIELKYLLRQGRPAVQALHELEVLT-TDYAGEDTSLLSTDPGHRSTYGPATFRTIVRGRLYVRTSNFGSGTDGSRQ--TAVDHRPSAAHIITPCRANC----------------------GFRGGRLFPRQFL---QPSGRNTMEVDRLDGHAASGRTAASAAP-----EDSETCRKLHCMAAVRRREEAAKMQDLSQEGQPTGE-----------------LPSVQLSAERRKAEMITAMLRENITTLHLLYASLGSAEFMEFVLKNPFDVPQSVSIHSDDPELSV-ITNAEEWRYYKETTQTPTPLLENMFHMEGGAEGPMVYLRPKESVHIPLKYQSFFCQSATVLQGPGFLPTSQTSQMAKKNPSKIPAAK-TIQVTFLAEGGRPLAILHLRVEPTPHLVHQTFRLYHPELGFLKKAIRLPLDPAAGQADGGTAV----RCSDPDIICQTRTLVPGGPQHVFLKVPGSPSPDIRLFFVMLFVDAWMAAPSQIWQIFVHFLERVDVSCVTGQQHCQAVILRGRKAVHTVRCFPSHPRELQVDPA--GVFVLPPGAVQELQLKLQPWQAGRRFMYVNAVEGEQHGLLAAWLLCLSIHRPVLSKAFELCIPVGSGRGSSKRMTYRNPYSSRRTFLLHSDRPDLLQFREERFEVDGGESHAIGLRFAPTQTPGSAEILVYVNNLEEATEETFCV 1426

HSP 2 Score: 104.76 bits (260), Expect = 5.137e-22
Identity = 106/433 (24.48%), Postives = 186/433 (42.96%), Query Frame = 1

Query:   55 HKYIPPPKERQGNTKADNLSFC--IKLLDLDLSSRLVP------DTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQT----CIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----NVQDP-QXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ-VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            H+++PP   +     AD+ S     +L  + +S+  +P      + + +  ++A+LFD N   FFG+ W SS  +  N+      +  NQ +YF+T+ +   + V+ E++   T+ + +      G+ V  LL        ++  ++     + ++ GT R L   QL+   +    +K  + + L + +  H +      L+P+  +V  D+ I G E    G      P+L +    S+ ++ V ++PSL  FE  LL+ IN D L            S+ I ERRL VGVHNG  ++E    + L      V+ P       ++     S     +  ++     +  PN     IVF LEY+ + P   +    +   S       Q +RW  + PF Q+      +   ++L   GGS   P   LVY
Sbjct:   47 HRFVPP-SGQTARAAADSFSQSRGFQLGPMRISAPHLPQEMFAGEPDASFQLRATLFDRNQLLFFGRTWKSSAQKMKNQ-----KISFNQVLYFHTSLLVPGILVVLELVSISTKRDGSHQAVGRGFAVLELLSSGPQAPPVYGERR-----LNLHHGTPRGLLHPQLRDAADYSSYLKPIDGAHLDMELKNHPSLLSVAHLLPDNSIVSGDEDIPGPEPSPTGDA-LLRPQLPEMMPLSLNRLTVSLQPSLETFESRLLQLINADGLNMRQLGPEDAQKSVVIQERRLHVGVHNGWCFLEKPQVVVLERLASGVRGPTDGGAKRSKPVMDSSSSSTLSLRSSLQLWLVDHPN---IAIVFQLEYAFSAPTSIN--SALSATSTTRAAFLQCLRWGGWCPFQQQADWNSRE---IQLALQGGSKPNPFGVLVY 459

[Close]

BLAST of NPHP4 vs. Ensembl Medaka
Match: ENSORLT00000037071.1 (nephrocystin 4 [Source:NCBI gene;Acc:101155253])

HSP 1 Score: 379.022 bits (972), Expect = 1.345e-108
Identity = 250/860 (29.07%), Postives = 405/860 (47.09%), Query Frame = 1

Query: 1909 QIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDV-NGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLS-------------------GRLHIRMANLGSVPSKKYNGLTLIAH-PKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRT-------PHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMP--PLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFAL 4398
             +++  F E++D  G+   V+DP +    + + + E+ D  Q N ++FQF+ALTR    + +     ++F TFQFYRFP +++ RL L +     S+  +  P IL      G  +   PG  +++ +D  F++PGE   F+ YL   T+H+DVWDGDSLLLIGS A++L+ L RQG+ +VQ+  EL++++  D   E++S LS                   GRL++R +N GS         T + H P    II   +                            GG L     +   QP+     E+  L    +  + + S +P      + +  R  +   A + +     ++ L  E +   +                 L ++Q   E++K E+I   L   I    ++Y   G  E  E  +KN F++  +VSI  +D    V ITN +E R  K      T    ++ + +       +++R KESV IP KY +   Q+      P      +T       P K+ +     Q+ F     + L+IL ++V P P ++ QTFR +HPE  FL++ IR+P  P    A    A+    RC+D D++ +      G P  + LKVP  PSP +R F + L++D ++  P Q+W   VH   R+DV    GQ     ++L+G    H V+ F SHP E+ V P     F L      EL L L P + G R  +VN V+ E H L+ +W++C +   P +SK FE+ +P+G G+   KR+ ++NPY  ++ F L +DRPDL+  ++    ++  +   IG+ F P       +I V++N+ +   EETF +
Sbjct:  606 HLFSVSFPEVVDHRGQKAEVLDPKEPL--LFDPQREDADFLQDNLLVFQFLALTRTSAADADPGWPSNIFITFQFYRFPPVASQRLRLLS-----SDGAEGLPCILATVGKDGTVNSASPGLQLQFKVDDRFLRPGEKRRFLGYLALHTMHLDVWDGDSLLLIGSTAIELKYLLRQGRPAVQALHELEVLT-TDYAGEDTSLLSTDPGHRSTYGPATFRTIVRGRLYVRTSNFGSGTDGSRQ--TAVDHRPSAAHIITPCRANC----------------------GFRGGRLFPRQFL---QPSGRNTMEVDRLDGHAASGRTAASAAP-----EDSETCRKLHCMAAVRRREEAAKMQDLSQEGQPTGE-----------------LPSVQLSAERRKAEMITAMLRENITTLHLLYASLGSAEFMEFVLKNPFDVPQSVSIHSDDPELSV-ITNAEEWRYYKETTQTPTPLLENMFHMEGGAEGPMVYLRPKESVHIPLKYQSFFCQSATVLQGPGFLPTSQTSQMAKKNPSKIPAAK-TIQVTFLAEGGRPLAILHLRVEPTPHLVHQTFRLYHPELGFLKKAIRLPLDPAAGQADGGTAV----RCSDPDIICQTRTLVPGGPQHVFLKVPGSPSPDIRLFFVMLFVDAWMAAPSQIWQIFVHFLERVDVSCVTGQQHCQAVILRGRKAVHTVRCFPSHPRELQVDPA--GVFVLPPGAVQELQLKLQPWQAGRRFMYVNAVEGEQHGLLAAWLLCLSIHRPVLSKAFELCIPVGSGRGSSKRMTYRNPYSSRRTFLLHSDRPDLLQFREERFEVDGGESHAIGLRFAPTQTPGSAEILVYVNNLEEATEETFCV 1400

HSP 2 Score: 104.76 bits (260), Expect = 5.184e-22
Identity = 106/433 (24.48%), Postives = 186/433 (42.96%), Query Frame = 1

Query:   55 HKYIPPPKERQGNTKADNLS--FCIKLLDLDLSSRLVP------DTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQT----CIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----NVQDP-QXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ-VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            H+++PP   +     AD+ S     +L  + +S+  +P      + + +  ++A+LFD N   FFG+ W SS  +  N+      +  NQ +YF+T+ +   + V+ E++   T+ + +      G+ V  LL        ++  ++     + ++ GT R L   QL+   +    +K  + + L + +  H +      L+P+  +V  D+ I G E    G      P+L +    S+ ++ V ++PSL  FE  LL+ IN D L            S+ I ERRL VGVHNG  ++E    + L      V+ P       ++     S     +  ++     +  PN     IVF LEY+ + P   +    +   S       Q +RW  + PF Q+      +   ++L   GGS   P   LVY
Sbjct:   21 HRFVPP-SGQTARAAADSFSQSRGFQLGPMRISAPHLPQEMFAGEPDASFQLRATLFDRNQLLFFGRTWKSSAQKMKNQ-----KISFNQVLYFHTSLLVPGILVVLELVSISTKRDGSHQAVGRGFAVLELLSSGPQAPPVYGERR-----LNLHHGTPRGLLHPQLRDAADYSSYLKPIDGAHLDMELKNHPSLLSVAHLLPDNSIVSGDEDIPGPEPSPTGDA-LLRPQLPEMMPLSLNRLTVSLQPSLETFESRLLQLINADGLNMRQLGPEDAQKSVVIQERRLHVGVHNGWCFLEKPQVVVLERLASGVRGPTDGGAKRSKPVMDSSSSSTLSLRSSLQLWLVDHPN---IAIVFQLEYAFSAPTSIN--SALSATSTTRAAFLQCLRWGGWCPFQQQADWNSRE---IQLALQGGSKPNPFGVLVY 433

[Close]

BLAST of NPHP4 vs. Ensembl Medaka
Match: ENSORLT00000039909.1 (nephrocystin 4 [Source:NCBI gene;Acc:101155253])

HSP 1 Score: 354.369 bits (908), Expect = 1.452e-100
Identity = 232/792 (29.29%), Postives = 369/792 (46.59%), Query Frame = 1

Query: 2110 VFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLS-------------------GRLHIRMANLGSVPSKKYNGLTLIAH-PKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRT-------PHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMP--PLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFAL 4398
            +F TFQFYRFP +++ RL L +     S+  +  P IL      G  +   PG  +++ +D  F++PGE   F+ YL   T+H+DVWDGDSLLLIGS A++L+ L RQG+ +VQ+  EL++++  D   E++S LS                   GRL++R +N GS         T + H P    II   +                            GG L     +   QP+     E+  L    +  + + S +P      + +  R  +   A + +     ++ L  E +   +                 L ++Q   E++K E+I   L   I    ++Y   G  E  E  +KN F++  +VSI  +D    V ITN +E R  K      T    ++ + +       +++R KESV IP KY +   Q+      P      +T       P K+ +     Q+ F     + L+IL ++V P P ++ QTFR +HPE  FL++ IR+P  P    A    A+    RC+D D++ +      G P  + LKVP  PSP +R F + L++D ++  P Q+W   VH   R+DV    GQ     ++L+G    H V+ F SHP E+ V P     F L      EL L L P + G R  +VN V+ E H L+ +W++C +   P +SK FE+ +P+G G+   KR+ ++NPY  ++ F L +DRPDL+  ++    ++  +   IG+ F P       +I V++N+ +   EETF +
Sbjct:  611 IFITFQFYRFPPVASQRLRLLS-----SDGAEGLPCILATVGKDGTVNSASPGLQLQFKVDDRFLRPGEKRRFLGYLALHTMHLDVWDGDSLLLIGSTAIELKYLLRQGRPAVQALHELEVLT-TDYAGEDTSLLSTDPGHRSTYGPATFRTIVRGRLYVRTSNFGSGTDGSRQ--TAVDHRPSAAHIITPCRA----------------------NCGFRGGRLFPRQFL---QPSGRNTMEVDRLDGHAASGRTAASAAP-----EDSETCRKLHCMAAVRRREEAAKMQDLSQEGQPTGE-----------------LPSVQLSAERRKAEMITAMLRENITTLHLLYASLGSAEFMEFVLKNPFDVPQSVSIHSDDPELSV-ITNAEEWRYYKETTQTPTPLLENMFHMEGGAEGPMVYLRPKESVHIPLKYQSFFCQSATVLQGPGFLPTSQTSQMAKKNPSKIPAAK-TIQVTFLAEGGRPLAILHLRVEPTPHLVHQTFRLYHPELGFLKKAIRLPLDPAAGQADGGTAV----RCSDPDIICQTRTLVPGGPQHVFLKVPGSPSPDIRLFFVMLFVDAWMAAPSQIWQIFVHFLERVDVSCVTGQQHCQAVILRGRKAVHTVRCFPSHPRELQVDPA--GVFVLPPGAVQELQLKLQPWQAGRRFMYVNAVEGEQHGLLAAWLLCLSIHRPVLSKAFELCIPVGSGRGSSKRMTYRNPYSSRRTFLLHSDRPDLLQFREERFEVDGGESHAIGLRFAPTQTPGSAEILVYVNNLEEATEETFCV 1339

HSP 2 Score: 105.145 bits (261), Expect = 3.942e-22
Identity = 106/433 (24.48%), Postives = 186/433 (42.96%), Query Frame = 1

Query:   55 HKYIPPPKERQGNTKADNLS--FCIKLLDLDLSSRLVP------DTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQT----CIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALF--QLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFL-----NVQDP-QXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQ-VRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVY 1290
            H+++PP   +     AD+ S     +L  + +S+  +P      + + +  ++A+LFD N   FFG+ W SS  +  N+      +  NQ +YF+T+ +   + V+ E++   T+ + +      G+ V  LL        ++  ++     + ++ GT R L   QL+   +    +K  + + L + +  H +      L+P+  +V  D+ I G E    G      P+L +    S+ ++ V ++PSL  FE  LL+ IN D L            S+ I ERRL VGVHNG  ++E    + L      V+ P       ++     S     +  ++     +  PN     IVF LEY+ + P   +    +   S       Q +RW  + PF Q+      +   ++L   GGS   P   LVY
Sbjct:   21 HRFVPP-SGQTARAAADSFSQSRGFQLGPMRISAPHLPQEMFAGEPDASFQLRATLFDRNQLLFFGRTWKSSAQKMKNQ-----KISFNQVLYFHTSLLVPGILVVLELVSISTKRDGSHQAVGRGFAVLELLSSGPQAPPVYGERR-----LNLHHGTPRGLLHPQLRDAADYSSYLKPIDGAHLDMELKNHPSLLSVAHLLPDNSIVSGDEDIPGPEPSPTGDA-LLRPQLPEMMPLSLNRLTVSLQPSLETFESRLLQLINADGLNMRQLGPEDAQKSVVIQERRLHVGVHNGWCFLEKPQVVVLERLASGVRGPTDGGAKRSKPVMDSSSSSTLSLRSSLQLWLVDHPN---IAIVFQLEYAFSAPTSIN--SALSATSTTRAAFLQCLRWGGWCPFQQQADWNSRE---IQLALQGGSKPNPFGVLVY 433

[Close]

BLAST of NPHP4 vs. Planmine SMEST
Match: SMESG000062716.1 (SMESG000062716.1)

HSP 1 Score: 2925.19 bits (7582), Expect = 0.000e+0
Identity = 1458/1462 (99.73%), Postives = 1459/1462 (99.79%), Query Frame = 1

Query:   28 MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQXXXXXXXXXXXXXKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEXXXXXXXXXXXXXXNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYXXXXXXXXXXXXXXRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 4413
            MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHL+INIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKS VKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQIRRTSTRRPSSISKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEDKIVDYDVIDPYVVNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYA GFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEK TPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYSKASLSSSKLGGSLRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ
Sbjct:    1 MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNENIYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFMDEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISIPVYKGTARALFQLKGFPESDPRVKAFENSFLHLNINIHKAFDVCHTLIPEYFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEFEKELLENINNDRLERDGKSLVKDASSLRIVERRLRVGVHNGIMYIEDNDTIFLNVQDPQIRRTSTRRPSSISKHEEHNCLTAKNSIEISMPNDQEFTIVFILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDGIRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAVMREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKTKLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQISNSISAPPPILSVPFPNHMINMWYTKQLGEDKIVDYDVIDPYVVNDKGFTSMVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAVGFQEILDCNGEHPFVIDPNQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQFYRFPVISTDRLILDNIIDQISNYEKPTPMILRKSESSGAPSVLPPGTMIKYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLCRQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNGLTLIAHPKKGLIIDASQIEGYSKASLSSSKLGGSLRDIYRTDDITGGHLGYSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGTNHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQCYREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSIEINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRSKESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTAEDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNEAIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYIDKFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTSHPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHTLIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYLSTDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGKNEETFALLVNYQ 1462

The following BLAST results are available for this feature:

BLAST of NPHP4 vs. Ensembl Human
BLAST of NPHP4 vs. Ensembl Celegans
BLAST of NPHP4 vs. Ensembl Fly
BLAST of NPHP4 vs. Ensembl Zebrafish
BLAST of NPHP4 vs. Ensembl Xenopus
BLAST of NPHP4 vs. Ensembl Mouse
BLAST of NPHP4 vs. UniProt/SwissProt
BLAST of NPHP4 vs. TrEMBL
BLAST of NPHP4 vs. Ensembl Cavefish
BLAST of NPHP4 vs. Ensembl Sea Lamprey
BLAST of NPHP4 vs. Ensembl Yeast
BLAST of NPHP4 vs. Ensembl Nematostella
BLAST of NPHP4 vs. Ensembl Medaka
BLAST of NPHP4 vs. Planmine SMEST

BLAST of NPHP4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPHP4	1.746e-135	32.62	nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104]	[more]
NPHP4	3.505e-39	36.88	nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104]	[more]
NPHP4	3.505e-39	36.88	nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104]	[more]
NPHP4	6.788e-28	46.09	nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104]	[more]
NPHP4	1.531e-7	23.94	nephrocystin 4 [Source:HGNC Symbol;Acc:HGNC:19104]	[more]

BLAST of NPHP4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
nphp-4	9.300e-21	28.45	NePHronoPhthisis (Human kidney disease) homolog; N...	[more]

BLAST of NPHP4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NPHP4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
nphp4	7.714e-127	33.10	nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-06050...	[more]
nphp4	8.549e-127	33.10	nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-06050...	[more]
nphp4	2.277e-126	32.95	nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-06050...	[more]
BX005102.1	5.613e-91	35.48	pep chromosome:GRCz11:CHR_ALT_CTG8_1_7:21978667:22...	[more]
nphp4	7.806e-22	29.15	nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-06050...	[more]

BLAST of NPHP4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
vac14	8.502e-156	34.78	Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921]	[more]
vac14	2.173e-155	35.01	Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921]	[more]
vac14	4.808e-155	34.70	Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921]	[more]
vac14	6.561e-154	34.91	Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921]	[more]
vac14	1.627e-153	34.48	Vac14 homolog [Source:Xenbase;Acc:XB-GENE-975921]	[more]

BLAST of NPHP4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Nphp4	1.450e-166	28.14	nephronophthisis 4 (juvenile) homolog (human) [Sou...	[more]
Nphp4	1.450e-166	28.14	nephronophthisis 4 (juvenile) homolog (human) [Sou...	[more]

BLAST of NPHP4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|P59240\|NPHP4_MOUSE	1.014e-165	28.14	Nephrocystin-4 OS=Mus musculus OX=10090 GN=Nphp4 P...	[more]
sp\|B0DOB4\|NPHP4_XENLA	3.048e-157	35.16	Nephrocystin-4 OS=Xenopus laevis OX=8355 GN=nphp4 ...	[more]
sp\|O75161\|NPHP4_HUMAN	8.384e-135	32.62	Nephrocystin-4 OS=Homo sapiens OX=9606 GN=NPHP4 PE...	[more]

BLAST of NPHP4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YJI8	0.000e+0	100.00	NPHP4 OS=Schmidtea mediterranea OX=79327 GN=NPHP4 ...	[more]
W5MFT0	0.000e+0	28.61	Nephrocystin 4 OS=Lepisosteus oculatus OX=7918 GN=...	[more]
A0A2T7PTM2	6.790e-176	30.35	Uncharacterized protein OS=Pomacea canaliculata OX...	[more]
A0A210PMI3	1.141e-175	35.92	Nephrocystin-4 OS=Mizuhopecten yessoensis OX=6573 ...	[more]
A0A4W3GM71	1.041e-173	29.59	Uncharacterized protein OS=Callorhinchus milii OX=...	[more]

BLAST of NPHP4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSAMXT00000022163.2	1.480e-85	33.19	pep primary_assembly:Astyanax_mexicanus-2.0:6:9839...	[more]
nphp4	8.039e-15	25.18	nephronophthisis 4 [Source:ZFIN;Acc:ZDB-GENE-06050...	[more]

BLAST of NPHP4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000002494.1	1.114e-34	37.89	pep scaffold:Pmarinus_7.0:GL480100:17735:27439:-1 ...	[more]
ENSPMAT00000007242.1	9.126e-17	38.18	pep scaffold:Pmarinus_7.0:GL477828:60629:68621:1 g...	[more]
ENSPMAT00000003405.1	1.152e-10	35.58	pep scaffold:Pmarinus_7.0:GL480964:6714:22420:1 ge...	[more]
ENSPMAT00000003407.1	5.429e-10	38.89	pep scaffold:Pmarinus_7.0:GL480964:6774:22456:1 ge...	[more]

BLAST of NPHP4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of NPHP4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO41800	4.667e-64	45.61	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of NPHP4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000040456.1	4.447e-109	29.07	nephrocystin 4 [Source:NCBI gene;Acc:101155253]	[more]
ENSORLT00000032624.1	8.864e-109	29.07	nephrocystin 4 [Source:NCBI gene;Acc:101155253]	[more]
ENSORLT00000041622.1	1.130e-108	29.07	nephrocystin 4 [Source:NCBI gene;Acc:101155253]	[more]
ENSORLT00000037071.1	1.345e-108	29.07	nephrocystin 4 [Source:NCBI gene;Acc:101155253]	[more]
ENSORLT00000039909.1	1.452e-100	29.29	nephrocystin 4 [Source:NCBI gene;Acc:101155253]	[more]

BLAST of NPHP4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000062716.1	0.000e+0	99.73	SMESG000062716.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30022153
GenBank	AKN21706.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30022153 ID=SMED30022153|Name=NPHP4|organism=Schmidtea mediterranea sexual|type=transcript|length=4448bp
CAATTATAAACTTTAATTTTTCGAAAAATGGATTTAAGAGTATTAAGTGA
AAAGCATAAATACATACCACCTCCAAAAGAGAGACAAGGAAATACAAAGG
CTGATAACTTATCATTTTGTATTAAGCTGTTAGATTTGGATTTAAGTTCC
CGTTTAGTGCCGGATACAAATGAAAACATTTATATTAAAGCGAGTTTATT
CGATTTTAATTATCAGTCATTTTTCGGTAAACAATGGGACAGTAGTACCA
TGGAAAATCTCAACAAACATGATGATATTTTTACAATGCAATGCAATCAA
CCGATCTATTTTTACACTGCATTTATGGATGAATATTTGTCCGTAATTTT
TGAAATAATACGTTATAAAACAGAAGACAATCAAACTTGCATTGGATGGT
GCGTTTTTAATTTACTAAAATGTACAAAGGTAGTGACGGATTTACATTCT
AATAAAAAATCAGAAACAATTTCTATACCGGTGTACAAAGGAACGGCACG
GGCTTTATTTCAGTTAAAAGGATTTCCAGAATCTGATCCTAGAGTAAAAG
CATTTGAAAATTCATTTCTCCATCTCAGCATTAATATTCATAAGGCATTT
GATGTATGTCATACATTGATTCCTGAATATTTCCTTGTCCACGAAGATGA
TATCATTTCAGGATTGGAAGTCGATAACGAAGGGTTTTGTGATTTCGAAA
ATCCAAGACTCACAAAATTTAAAAATTATTCAATAGAAAAAGTTAAAGTT
TTTATTGAGCCGTCTTTGATGGAGTTCGAAAAAGAACTGCTAGAGAATAT
TAACAACGACAGACTGGAGAGAGATGGAAAATCATTCGTCAAAGATGCTT
CTTCACTGAGGATCGTTGAGAGACGATTAAGAGTCGGAGTTCATAACGGT
ATAATGTATATTGAAGACAATGATACAATATTTCTGAATGTACAAGATCC
CCAAATCAGACGCACTTCTACCAGAAGACCCTCCTCAATTTCTAAACACG
AGGAGCATAATTGTTTGACTGCGAAAAATTCTATTGAAATTTCGATGCCA
AACGATCAAGAATTTACAATCGTATTCATTTTAGAATACTCTATTGCTGA
GCCTGTTTATTCCGATGGTAGAAAAGATATAGGCATAATGTCACCTTTAC
CTCAACATACCTATCAAGTCAGATGGATAGTTTATCAGCCCTTTGCTCAA
AAAAATGCAGTGACTTTTAATGACGGTATTCGATTAGAACTTGATTTTTC
CGGTGGCTCAATTGATGCGCCAGAAAATTATCTAGTGTATAAGCCCGATT
CAGTGCTACGGAAAATTGAACAAGGAGATGGAGAATTTACCGCCGGAGAG
AAGAATTATTCAAAATTGATTGCTGTTATGAGGGAAAAGGATCCTAACGA
GAAAGAACCGTCACATTCAATTACTATTTCACCAGCAAATGTTGCAGATG
GGTCTGTTGAAGATGAAATCAAAATTAAAGAAAGTAGAACGTTGTCAGAG
CCACCAAAACCGCAAACTAGAAAAACGAAATTAACCAAATCACAGAAAGT
AAATCTGGACGAAAACGTTAAAGTAAGAGACGTGGAAAATGTTCAAGAAG
CTCAAATTAGAGCTTATCAACAATTTCTGATGATGCAACAGGAAACTTTA
AAACAAGAATCTCAAAGGCAAATTTCCAATTCAATATCAGCACCTCCGCC
TATTCTGAGTGTCCCGTTTCCAAACCATATGATTAACATGTGGTACACGA
AACAACTTGGTGAAGATAAAATCGTTGATTATGATGTCATAGATCCTTAT
GTTGTCAATGACAAAGGATTTACATCCATGGTTCAACAGAATAATTTGGC
ATTTCCTTTACAAATGCGTTCTCATCATGGATTAGGACTATCTCGGGCCA
TTTATTCTCAGATTTATGCAGCAGGATTCCAGGAAATATTGGACTGTAAT
GGTGAACATCCATTTGTAATAGACCCCAATCAAGATCAAGATAATGTAGT
CAATTTTGAATTAGAAGAAAGAGATCATAAGCAATGCAACGAAATCATTT
TTCAATTTATGGCACTGACCAGATTTGACGTTAACGGAAACAGTCGGCCT
ACAAAATCAGTATTTTTTACTTTTCAATTCTATCGTTTTCCTGTGATTTC
TACAGATCGCCTGATTTTAGATAATATCATTGACCAGATTTCTAATTACG
AAAAAGCTACTCCAATGATTTTGCGAAAGTCTGAATCATCTGGAGCTCCC
AGTGTTCTTCCTCCTGGAACAATGATAAAATATATGCTAGACCCGGCATT
CATGAAACCTGGAGAGATGATAAGTTTTATTGAATATTTGAATCAACAAA
CTTTACATGTCGATGTTTGGGATGGAGATTCACTTCTTCTAATTGGCAGT
TGTGCCGTTAAACTAAGGAATCTTTGTCGACAAGGAAAAATTTCTGTTCA
AAGTTCTTTCGAATTAGACATTATAAGTCCGGTCGATATTGATGACGAAA
ACAGCTCCAAACTTAGCGGTCGCCTTCACATTCGAATGGCAAATTTAGGG
TCAGTTCCAAGTAAGAAATACAACGGATTGACTTTGATTGCTCATCCTAA
GAAAGGATTGATTATCGATGCTTCACAAATAGAAGGATATTCAAAGGCAT
CGTTATCTTCTTCAAAACTTGGGGGCAGTCTAAGAGATATCTATAGGACT
GATGATATTACAGGAGGCCATTTAGGTTATTCAAATATTGTTGTACGGCC
TCAGCCTGCTATAGCTAAAAATCGAGAATTATCCGAATTGATAGAAACTA
AAAGTCATTCAAAAGGTTCTGAATCAATGAGTCCTGTTAAAGGTCCATTA
ATGAATGAAGATATTATTCGAGGAACAAATCATGATGAAGCCAAAAAACT
TAAAAGATTCAAAAATACTTTACGACAATTGGAGAATGAAAACGAAAATA
TAAATGATCAACTTCTTTCTGAAGCTAAACGTTCTGATAAAGTGGAAAAA
CAGATAATTTTGCAAACAATTCAATGTTACAGAGAACAACAAAAAGGTGA
AGTTATAAAAAAGTGGCTAAATGGAGTAATCGAAAAAGAAATAGTAATTT
ATCCGAAATTCGGCTGTACGGAAATGTTCGAAGTGAAAATTAAAAACCAT
TTTAATATTGACAGTAATGTTAGTATTGAGATCAACGATTCCAGGTATTT
GGTGCCAATTACAAATAACCAAGAACTAAGAGCATTGAAGTCCATGTTTT
CAATCACTACGGTTTCGGAAAATGATCTCATCAACTTCGATGCTGAGAAA
AACATTTATCAGATATTTATGAGATCCAAAGAATCGGTTTTAATTCCTTT
CAAGTATACTAATATGGCACTACAGGCTGATCAGAGCTTTGCCTCTCCTG
CTATGTCTAGTCCAGTAAGAACGCCTCATAAGCTTGCATCAGTTGACCTA
GAATATCAAATTGTTTTCCGAACCGCTGAAGACAAGTTGCTTTCTATTCT
ACGAGTGAAAGTTGTACCTCAACCGCCGATAATTGATCAAACATTCAGAT
TTTTTCATCCTGAACAAAGTTTTCTACGAAGACATATCAGAATGCCTCCT
TTGCATATGATTGCTAGTCATAACGAAGCCATCAAAATTTTATCAAGATG
TACAGATTCAGATGTTTTATCAGAATGTCCCCTGAAACCCATTGGAACTC
CTCACGATATACAATTAAAAGTGCCATGTGGACCTTCTCCTCAAGTTCGT
CAGTTTTTACTCGCGCTATACATTGATAAGTTTTTGCTGAAACCGATCCA
AGTATGGCATTTCACTGTGCATTCGAAATCTCGCATCGATGTGGTCGCCC
ACCAAGGACAGTCGACGAATATGACACTGTTGCTCAAAGGAGCATCCAAT
ACTCACAATGTACAAGTATTTACTAGTCATCCGGAAGAAATTTTAGTTGC
ACCGATAGAAAACAACAGTTTCTCTTTATCTGCTCATACTACGTATGAAT
TATCTCTCAATTTGACCCCTGTTAAAATTGGAAATCGGAAATTTCATGTC
AACGTTGTCGATATTGAAAGCCACACTCTGATTCGTTCATGGGTCATTTG
TGCGACATGTAAGGAGCCGGAAATATCGAAAATGTTTGAAATGCAATTAC
CAATCGGAGGTGGACAAGTCTGTAAAAAACGAATCGGTTTCCAAAATCCG
TATCCATATCAAAAAAGATTCTATTTAAGTACGGATAGACCAGATCTAGT
TTTGCTCAAGGACACGATTTTGACAATCGAGGCAAACCAAGTGGAAAATA
TTGGTATGATTTTTGTCCCGATATTTCAACGGTGCCGACAAAAGATTTTT
GTTTTTATTAATGATGAAGACGGTAAAAATGAAGAAACATTTGCTCTTCT
TGTTAATTATCAATGACTATTTTGATCTTTATTCTTATAATTTCCGAT

protein sequence of SMED30022153-orf-1

>SMED30022153-orf-1 ID=SMED30022153-orf-1|Name=SMED30022153-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1463bp
MDLRVLSEKHKYIPPPKERQGNTKADNLSFCIKLLDLDLSSRLVPDTNEN
IYIKASLFDFNYQSFFGKQWDSSTMENLNKHDDIFTMQCNQPIYFYTAFM
DEYLSVIFEIIRYKTEDNQTCIGWCVFNLLKCTKVVTDLHSNKKSETISI
PVYKGTARALFQLKGFPESDPRVKAFENSFLHLSINIHKAFDVCHTLIPE
YFLVHEDDIISGLEVDNEGFCDFENPRLTKFKNYSIEKVKVFIEPSLMEF
EKELLENINNDRLERDGKSFVKDASSLRIVERRLRVGVHNGIMYIEDNDT
IFLNVQDPQIRRTSTRRPSSISKHEEHNCLTAKNSIEISMPNDQEFTIVF
ILEYSIAEPVYSDGRKDIGIMSPLPQHTYQVRWIVYQPFAQKNAVTFNDG
IRLELDFSGGSIDAPENYLVYKPDSVLRKIEQGDGEFTAGEKNYSKLIAV
MREKDPNEKEPSHSITISPANVADGSVEDEIKIKESRTLSEPPKPQTRKT
KLTKSQKVNLDENVKVRDVENVQEAQIRAYQQFLMMQQETLKQESQRQIS
NSISAPPPILSVPFPNHMINMWYTKQLGEDKIVDYDVIDPYVVNDKGFTS
MVQQNNLAFPLQMRSHHGLGLSRAIYSQIYAAGFQEILDCNGEHPFVIDP
NQDQDNVVNFELEERDHKQCNEIIFQFMALTRFDVNGNSRPTKSVFFTFQ
FYRFPVISTDRLILDNIIDQISNYEKATPMILRKSESSGAPSVLPPGTMI
KYMLDPAFMKPGEMISFIEYLNQQTLHVDVWDGDSLLLIGSCAVKLRNLC
RQGKISVQSSFELDIISPVDIDDENSSKLSGRLHIRMANLGSVPSKKYNG
LTLIAHPKKGLIIDASQIEGYSKASLSSSKLGGSLRDIYRTDDITGGHLG
YSNIVVRPQPAIAKNRELSELIETKSHSKGSESMSPVKGPLMNEDIIRGT
NHDEAKKLKRFKNTLRQLENENENINDQLLSEAKRSDKVEKQIILQTIQC
YREQQKGEVIKKWLNGVIEKEIVIYPKFGCTEMFEVKIKNHFNIDSNVSI
EINDSRYLVPITNNQELRALKSMFSITTVSENDLINFDAEKNIYQIFMRS
KESVLIPFKYTNMALQADQSFASPAMSSPVRTPHKLASVDLEYQIVFRTA
EDKLLSILRVKVVPQPPIIDQTFRFFHPEQSFLRRHIRMPPLHMIASHNE
AIKILSRCTDSDVLSECPLKPIGTPHDIQLKVPCGPSPQVRQFLLALYID
KFLLKPIQVWHFTVHSKSRIDVVAHQGQSTNMTLLLKGASNTHNVQVFTS
HPEEILVAPIENNSFSLSAHTTYELSLNLTPVKIGNRKFHVNVVDIESHT
LIRSWVICATCKEPEISKMFEMQLPIGGGQVCKKRIGFQNPYPYQKRFYL
STDRPDLVLLKDTILTIEANQVENIGMIFVPIFQRCRQKIFVFINDEDGK
NEETFALLVNYQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR029775	NPHP4
IPR000008	C2_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0005856	cytoskeleton
GO:0097730	non-motile cilium

Vocabulary: **biological process**
Term	Definition
GO:0090090	negative regulation of canonical Wnt signaling pathway

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 951..985
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 485..505
IPR029775	Nephrocystin-4	PANTHER	PTHR31043	FAMILY NOT NAMED	coord: 9..1462

Main menu

NPHP4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

blazegraph-runner