NAD(P)H-hydrate epimerase

Overview
NameNAD(P)H-hydrate epimerase
Smed IDSMED30021937
Length (bp)1753
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of NAD(P)H-hydrate epimerase (SMED30021937) t-SNE clustered cells

Violin plots show distribution of expression levels for NAD(P)H-hydrate epimerase (SMED30021937) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NAD(P)H-hydrate epimerase (SMED30021937) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NAD(P)H-hydrate epimerase (SMED30021937) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021937

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
Smed sexual biotypeSMED30021937h1SMcG0022136 Contig55033uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021937h1SMcG0022136 Contig55033newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021937h1SMcG0022135 Contig55033uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021937h1SMcG0022135 Contig55033newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30021937h1SMcG0022136 OX_Smed_1.0.16051ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
ovarySMED30021937h1SMcG0022135 SMED30021937smed_20140614PMID:279364
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
testisSMED30021937h1SMcG0022135 SMED30021937smed_20140614PMID:279364
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
ovarySMED30021937h1SMcG0022136 SMED30021937smed_20140614PMID:279364
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
testisSMED30021937h1SMcG0022136 SMED30021937smed_20140614PMID:279364
whole organism adult hermaphrodite colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Match: RNF121 (ring finger protein 121 [Source:HGNC Symbol;Acc:HGNC:21070])

HSP 1 Score: 389.808 bits (1000), Expect = 7.556e-132
Identity = 172/305 (56.39%), Postives = 231/305 (75.74%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D+S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGVVQGINYILGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Match: RNF121 (ring finger protein 121 [Source:HGNC Symbol;Acc:HGNC:21070])

HSP 1 Score: 379.793 bits (974), Expect = 1.813e-128
Identity = 167/294 (56.80%), Postives = 224/294 (76.19%), Query Frame = 3 
Query:  801 KLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:    2 RVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGVVQGINYILGLE 295
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Match: RNF175 (ring finger protein 175 [Source:HGNC Symbol;Acc:HGNC:27735])

HSP 1 Score: 360.918 bits (925), Expect = 1.232e-120
Identity = 159/303 (52.48%), Postives = 225/303 (74.26%), Query Frame = 3 
Query:  774 SKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +KLS  +   L+  ++++ HRGH++MH+EM LI +  L+I Q +L+QWRQRH +S+   TL+ MW+VP+  +    W+RF+ +W +FS++T+ + F ATRKP++  TP  VY WFLLIYKLSY FG+VGYL IM T+ G N+ F IK   +MDFG +  FYGLY+GV+GRD + +CSD MA+ IG+Y+ S +PTR+L +++CAVCG K+  E  E+      Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RM  NPWE+ H LYG +LDW+RYLVAWQP++  I+ G+ ++ GL+
Sbjct:   26 TKLSAEDTWNLQQERMYKMHRGHDSMHVEMILIFLCVLVIAQIVLVQWRQRHGRSYNLVTLLQMWVVPLYFTIKLYWWRFLSMWGMFSVITSYILFRATRKPLSGRTPRLVYKWFLLIYKLSYAFGVVGYLAIMFTMCGFNLFFKIKARDSMDFGIVSLFYGLYYGVMGRDFAEICSDYMASTIGFYSVSRLPTRSLSDNICAVCGQKIIVELDEEGLIENTYQLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYLVAWQPVVIGIVQGIIYSLGLE 328
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Match: NAXE (NAD(P)HX epimerase [Source:HGNC Symbol;Acc:HGNC:18453])

HSP 1 Score: 273.478 bits (698), Expect = 4.221e-87
Identity = 134/231 (58.01%), Postives = 166/231 (71.86%), Query Frame = 3 
Query:   75 NIMSS--VKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
             +M+S  VKYL+QEEA+ +D ELFNE+ FSVDQLMELAGLSCATAI +AYP  + SR   ++L+ CGPGNNGGDGLVCARHLKLFGY+P I+YPK+ +  LF  LV QC KM+IPF     +  ++ID  ++ +VDA+FGFSFK  VR  F  I++ L    +PI SIDIPSGW+VE G      I+P+ +ISLTAPK     F G+ H+LGGRFVP  L  KY LNLP Y
Sbjct:   50 EVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKG--NAGGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPY 278
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Match: RNF121 (ring finger protein 121 [Source:HGNC Symbol;Acc:HGNC:21070])

HSP 1 Score: 216.468 bits (550), Expect = 2.069e-66
Identity = 98/176 (55.68%), Postives = 129/176 (73.30%), Query Frame = 3 
Query:  801 KLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIG 1328
            ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG
Sbjct:    2 RVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIG 177
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Celegans
Match: rnf-121 (RING finger protein 121 [Source:UniProtKB/Swiss-Prot;Acc:Q09251])

HSP 1 Score: 348.591 bits (893), Expect = 3.778e-116
Identity = 155/314 (49.36%), Postives = 216/314 (68.79%), Query Frame = 3 
Query:  777 KLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLD-----------------SEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +L++ E+   EH K+HE+H+GHE MH+EM +I ++ +I+ Q  L+ W+++H KS+Q  TLIGM  +P+ + F  SW+RF+  W VF I +A +   A+ + ++  TP  VY WFL ++KLSY  G+VGYL++M  L G ++LF +     MD G L  FYG+Y+GV+GRD + +C+ +MA++IGYYT  G+P + L++ VCAVCG +LD                  +E EK YKL+CGH FH+FCIRGW ++GK QTCPYC+ERVDLQRMFKNPWEKPHL YG LLDW+RYLV WQPLI   + G+    GL+
Sbjct:   22 ELTEEEQWAEEHRKMHEKHKGHEAMHMEMMVIFMISVIVGQIFLVTWKRKHFKSYQMCTLIGMLTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFVYKWFLFLHKLSYVLGVVGYLIMMGALLGFHVLFGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMVEDEDEKLYKLSCGHVFHEFCIRGWVVVGKLQTCPYCKERVDLQRMFKNPWEKPHLFYGKLLDWIRYLVCWQPLIVTAVQGLTTWMGLE 335
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Celegans
Match: Y18D10A.3 (NAD(P)H-hydrate epimerase [Source:UniProtKB/Swiss-Prot;Acc:Q9XW15])

HSP 1 Score: 193.356 bits (490), Expect = 3.891e-56
Identity = 107/228 (46.93%), Postives = 145/228 (63.60%), Query Frame = 3 
Query:   87 SVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDG-PVENEH--IKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            +V ++ Q+ A  ID +LF ++ F V+QLMELAGL+ A AI   YP  N       + + CGPGNNGGDG VCARHL+ FG+ P I YPK+S  +L ++LV+QC    IP T    + +     +F  IVDALFGFSF PP R  F  ++  +  + + + SID+PSGW+VE G P  N+   I P ++ISLT PKLC+K + G  HFLGGRFVP  L  ++ L +P+Y
Sbjct:  122 TVSFIGQKLAAQIDEQLFTKYGFKVEQLMELAGLAAAQAIAAHYPKSN-------VAVLCGPGNNGGDGFVCARHLQQFGFTPSIVYPKESRNELMKSLVVQCETSSIPITATLPTNL----QAFPLIVDALFGFSFHPPTREPFTEMLKTVRASGIHVFSIDVPSGWDVELGAPSGNDDDVIHPHSVISLTLPKLCMKNWTGP-HFLGGRFVPKSLVDEHELLMPQY 337
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Celegans
Match: toe-4 (Target Of ERK kinase MPK-1 [Source:UniProtKB/TrEMBL;Acc:Q9XUM8])

HSP 1 Score: 51.2174 bits (121), Expect = 1.453e-6
Identity = 24/54 (44.44%), Postives = 28/54 (51.85%), Query Frame = 3 
Query: 1365 DEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVD 1526
            DE  C VC +    E+ E   KL C H FH  CI  W  I K+  CP CRE +D
Sbjct:  429 DEDTCTVCLSSF--EDGESIQKLRCNHVFHPECIYKWLDINKR--CPMCREEID 478
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Match: CG15814 (gene:FBgn0030873 transcript:FBtr0074468)

HSP 1 Score: 384.415 bits (986), Expect = 3.632e-130
Identity = 173/305 (56.72%), Postives = 225/305 (73.77%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
             L +++  ER + +H  + E+HRGH+ MH EM +IL V L+I Q +L++W++RH +S+   TL+ MWL+P+IIS    W RFI IW VF+ +TA++   A  KP+  TTP  VY WF  IYKLSY  G+VGYLVI++   G+N +F   P   MD G +  FYGLY GV+GRD+S +CSDKMAA IGYYT  G+PTR LD++VCAVCGN+L   EKE+      YKL+C H FH+FCIRGWCI+GKKQTCPYC+E+VDLQ+MF+NPWEKPH+LYG LLDW+R+LVAWQPLIF I+ G+ W  GL+
Sbjct:   17 SLDEMTPEERMRAQHQLMVEKHRGHDAMHSEMVIILFVTLVIAQIILVEWKKRHYRSYAFVTLLAMWLIPLIISCSFGWLRFIIIWLVFTCITALVMRRAISKPIQGTTPRLVYKWFYFIYKLSYGLGLVGYLVIIAAFLGMNYMFSQPPNTWMDVGLMFCFYGLYIGVLGRDISEICSDKMAAAIGYYTPQGIPTRHLDQNVCAVCGNQLLVSEKEEGVIENTYKLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLQKMFRNPWEKPHVLYGRLLDWIRWLVAWQPLIFFIVQGINWMLGLE 321
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Match: CG15814 (gene:FBgn0030873 transcript:FBtr0074470)

HSP 1 Score: 384.415 bits (986), Expect = 3.632e-130
Identity = 173/305 (56.72%), Postives = 225/305 (73.77%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
             L +++  ER + +H  + E+HRGH+ MH EM +IL V L+I Q +L++W++RH +S+   TL+ MWL+P+IIS    W RFI IW VF+ +TA++   A  KP+  TTP  VY WF  IYKLSY  G+VGYLVI++   G+N +F   P   MD G +  FYGLY GV+GRD+S +CSDKMAA IGYYT  G+PTR LD++VCAVCGN+L   EKE+      YKL+C H FH+FCIRGWCI+GKKQTCPYC+E+VDLQ+MF+NPWEKPH+LYG LLDW+R+LVAWQPLIF I+ G+ W  GL+
Sbjct:   17 SLDEMTPEERMRAQHQLMVEKHRGHDAMHSEMVIILFVTLVIAQIILVEWKKRHYRSYAFVTLLAMWLIPLIISCSFGWLRFIIIWLVFTCITALVMRRAISKPIQGTTPRLVYKWFYFIYKLSYGLGLVGYLVIIAAFLGMNYMFSQPPNTWMDVGLMFCFYGLYIGVLGRDISEICSDKMAAAIGYYTPQGIPTRHLDQNVCAVCGNQLLVSEKEEGVIENTYKLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLQKMFRNPWEKPHVLYGRLLDWIRWLVAWQPLIFFIVQGINWMLGLE 321
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Match: CG15814 (gene:FBgn0030873 transcript:FBtr0074469)

HSP 1 Score: 384.415 bits (986), Expect = 3.632e-130
Identity = 173/305 (56.72%), Postives = 225/305 (73.77%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
             L +++  ER + +H  + E+HRGH+ MH EM +IL V L+I Q +L++W++RH +S+   TL+ MWL+P+IIS    W RFI IW VF+ +TA++   A  KP+  TTP  VY WF  IYKLSY  G+VGYLVI++   G+N +F   P   MD G +  FYGLY GV+GRD+S +CSDKMAA IGYYT  G+PTR LD++VCAVCGN+L   EKE+      YKL+C H FH+FCIRGWCI+GKKQTCPYC+E+VDLQ+MF+NPWEKPH+LYG LLDW+R+LVAWQPLIF I+ G+ W  GL+
Sbjct:   17 SLDEMTPEERMRAQHQLMVEKHRGHDAMHSEMVIILFVTLVIAQIILVEWKKRHYRSYAFVTLLAMWLIPLIISCSFGWLRFIIIWLVFTCITALVMRRAISKPIQGTTPRLVYKWFYFIYKLSYGLGLVGYLVIIAAFLGMNYMFSQPPNTWMDVGLMFCFYGLYIGVLGRDISEICSDKMAAAIGYYTPQGIPTRHLDQNVCAVCGNQLLVSEKEEGVIENTYKLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLQKMFRNPWEKPHVLYGRLLDWIRWLVAWQPLIFFIVQGINWMLGLE 321
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Match: CG15814 (gene:FBgn0030873 transcript:FBtr0074471)

HSP 1 Score: 382.489 bits (981), Expect = 1.121e-129
Identity = 172/297 (57.91%), Postives = 221/297 (74.41%), Query Frame = 3 
Query:  792 ERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            ER + +H  + E+HRGH+ MH EM +IL V L+I Q +L++W++RH +S+   TL+ MWL+P+IIS    W RFI IW VF+ +TA++   A  KP+  TTP  VY WF  IYKLSY  G+VGYLVI++   G+N +F   P   MD G +  FYGLY GV+GRD+S +CSDKMAA IGYYT  G+PTR LD++VCAVCGN+L   EKE+      YKL+C H FH+FCIRGWCI+GKKQTCPYC+E+VDLQ+MF+NPWEKPH+LYG LLDW+R+LVAWQPLIF I+ G+ W  GL+
Sbjct:    5 ERMRAQHQLMVEKHRGHDAMHSEMVIILFVTLVIAQIILVEWKKRHYRSYAFVTLLAMWLIPLIISCSFGWLRFIIIWLVFTCITALVMRRAISKPIQGTTPRLVYKWFYFIYKLSYGLGLVGYLVIIAAFLGMNYMFSQPPNTWMDVGLMFCFYGLYIGVLGRDISEICSDKMAAAIGYYTPQGIPTRHLDQNVCAVCGNQLLVSEKEEGVIENTYKLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLQKMFRNPWEKPHVLYGRLLDWIRWLVAWQPLIFFIVQGINWMLGLE 301
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Match: Naxe (gene:FBgn0030178 transcript:FBtr0290234)

HSP 1 Score: 265.388 bits (677), Expect = 3.629e-85
Identity = 126/225 (56.00%), Postives = 160/225 (71.11%), Query Frame = 3 
Query:   87 SVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
             +KYLNQ+EA  +D ELFN++ FSVDQLMELAGLSCA A+ + +P +   R    IL+CCGPGNNGGDGLV ARHL L GY P I+YPK ++  LFENL  QC +M+I   +   S + S    +D I+DALFGFSFKPPVR +F  ++  +  T LPI S+DIPSGW+VE G +    ++P  +ISLTAPKLC + F+G++H+LGGRFVP  L  KY LNLP Y
Sbjct:    2 DLKYLNQKEAIAVDQELFNDYKFSVDQLMELAGLSCAHAVAKCFPAEKHPR----ILVCCGPGNNGGDGLVAARHLALMGYTPTIYYPKPTAKPLFENLSHQCQQMDICDVKECPS-VESAARDYDLILDALFGFSFKPPVRADFVAVVELMQQTKLPIASVDIPSGWDVEKGKLTECDVEPALLISLTAPKLCARQFRGEHHYLGGRFVPPALQRKYELNLPVY 221
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Match: rnf121 (ring finger protein 121 [Source:ZFIN;Acc:ZDB-GENE-050809-3])

HSP 1 Score: 385.185 bits (988), Expect = 3.556e-130
Identity = 170/305 (55.74%), Postives = 230/305 (75.41%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNK--LDSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+LS  E+ +L+H KLH +H+GHE MH EM LIL+V L++ Q  L+QW+QRH KS+   TL  MW++P+  +    W+RF+ +W  FSI+TA + F ATRKP+A TTP  VY WFLL YK++Y  GIVGY ++M TLFG+N+LF IKP   MD G  + FYGLYFGV+GRD + +C+D MA+ IGYYT+SG+PT+ L + +CAVCG    +D+ ++   E  Y+L C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF+NPWE+PH++YG LLDW+RYLVAWQP+I  ++  + +  GL+
Sbjct:   27 DLSRLSPEEKWRLDHAKLHAKHKGHEAMHAEMVLILIVTLVVAQLALVQWKQRHQKSYNMVTLFQMWVIPLYFTSKLHWWRFMVVWFTFSIITAFVTFRATRKPLACTTPRLVYKWFLLFYKINYGTGIVGYAIVMLTLFGINLLFGIKPDDCMDLGVSLLFYGLYFGVLGRDFAEICADVMASTIGYYTESGMPTKHLSDSICAVCGQTTLVDANQEGIIENTYRLTCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFRNPWERPHMMYGQLLDWLRYLVAWQPIIIGLVQLINYILGLE 331
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Match: rnf175 (ring finger protein 175 [Source:ZFIN;Acc:ZDB-GENE-040426-1104])

HSP 1 Score: 376.711 bits (966), Expect = 3.657e-127
Identity = 167/305 (54.75%), Postives = 226/305 (74.10%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DL K+S  E  K++H +LH +HRGHE MH EM LIL+  L++ Q +L+QW+QRH +S+   TL+ MW+VP+  +    W+RF+  W +FS++T+ + F ATRKP++  TP  VY WFLLIYKLSY  G++GYL IM T+FG N+ F IK   +MD G ++ FYGLY+GV+GRD + +CSD MA+ IGYY    +P+R L+  VCAVCG K+  D +E+   E  Y+L+C HTFH+FCIRGWCI+GKKQTCPYC E+VDL+RM  NPWE+ H+LYG LLDW+RYLVAWQP+I  I+HG+ ++ GL+
Sbjct:    9 DLLKMSHRESWKMQHERLHVKHRGHEAMHAEMVLILIATLVVAQIVLVQWKQRHCRSYNMVTLLQMWVVPLYFTIKLYWWRFLSTWGMFSVITSYVIFRATRKPLSCRTPRMVYKWFLLIYKLSYAVGVIGYLAIMFTMFGFNVFFRIKAEDSMDVGVIMLFYGLYYGVMGRDFAEICSDYMASTIGYYNMGDMPSRNLNNDVCAVCGQKIFVDVDEEGIIEDTYQLSCNHTFHEFCIRGWCIVGKKQTCPYCNEKVDLKRMMNNPWERTHVLYGQLLDWLRYLVAWQPIIIGIVHGINFSLGLE 313
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Match: rnf175 (ring finger protein 175 [Source:ZFIN;Acc:ZDB-GENE-040426-1104])

HSP 1 Score: 370.933 bits (951), Expect = 4.947e-125
Identity = 164/301 (54.49%), Postives = 223/301 (74.09%), Query Frame = 3 
Query:  780 LSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +S  E  K++H +LH +HRGHE MH EM LIL+  L++ Q +L+QW+QRH +S+   TL+ MW+VP+  +    W+RF+  W +FS++T+ + F ATRKP++  TP  VY WFLLIYKLSY  G++GYL IM T+FG N+ F IK   +MD G ++ FYGLY+GV+GRD + +CSD MA+ IGYY    +P+R L+  VCAVCG K+  D +E+   E  Y+L+C HTFH+FCIRGWCI+GKKQTCPYC E+VDL+RM  NPWE+ H+LYG LLDW+RYLVAWQP+I  I+HG+ ++ GL+
Sbjct:    1 MSHRESWKMQHERLHVKHRGHEAMHAEMVLILIATLVVAQIVLVQWKQRHCRSYNMVTLLQMWVVPLYFTIKLYWWRFLSTWGMFSVITSYVIFRATRKPLSCRTPRMVYKWFLLIYKLSYAVGVIGYLAIMFTMFGFNVFFRIKAEDSMDVGVIMLFYGLYYGVMGRDFAEICSDYMASTIGYYNMGDMPSRNLNNDVCAVCGQKIFVDVDEEGIIEDTYQLSCNHTFHEFCIRGWCIVGKKQTCPYCNEKVDLKRMMNNPWERTHVLYGQLLDWLRYLVAWQPIIIGIVHGINFSLGLE 301
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Match: naxe (NAD(P)HX epimerase [Source:NCBI gene;Acc:436891])

HSP 1 Score: 275.789 bits (704), Expect = 2.672e-88
Identity = 134/227 (59.03%), Postives = 169/227 (74.45%), Query Frame = 3 
Query:   84 SSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPF-TENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            + VKYL QEEA+ ID ELF++FSFSVDQLMELAGLSCATA+ + YP+ +  +    +L+ CGPGNNGGDGLVCARHLKLFGY+P + YPK+ + +LF+NL IQC KMEIPF TE  E+ +  ID ++  +VDA+FGFSFK  VR  F  I+++L    +PI S+DIPSGW+VE G  +   I+P+ +ISLTAPK     FKG+ HFLGGRFVP  L  KY LNLP+Y
Sbjct:   51 TGVKYLGQEEAQQIDEELFSDFSFSVDQLMELAGLSCATAVAKGYPVTSLLKSPARVLVICGPGNNGGDGLVCARHLKLFGYEPSVLYPKRPNKQLFQNLSIQCQKMEIPFLTEMPEADL--IDEAYSLVVDAIFGFSFKGAVREPFGEILSQLKKITVPIASVDIPSGWDVEKGCPDG--IQPDMLISLTAPKKSAALFKGRFHFLGGRFVPPVLEQKYQLNLPQY 273
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Match: yjefn3 (YjeF N-terminal domain containing 3 [Source:ZFIN;Acc:ZDB-GENE-050208-755])

HSP 1 Score: 194.126 bits (492), Expect = 1.396e-57
Identity = 92/228 (40.35%), Postives = 147/228 (64.47%), Query Frame = 3 
Query:   81 MSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFG-FSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            +  ++YL++ E   ++ EL  ++ F   QL+E+ G +CA AI +A+PL + S+   ++L+ CGP  NG  GLVCARHL++F Y+P IFYPK+S+  L ++  +QC KM+IPF     + +  ++++++ ++DA+ G  +    V+  +  ++  L    +PI+S+D+PSGW+  D P ++  I PE +ISLTAPK C   F GK HFL GRF+P  +  KY LNLPE+
Sbjct:   13 IEPLRYLSKTEVATVETELLRDYRFGQQQLIEIWGHACAIAITKAFPLSSLSKKQPTLLVVCGPEQNGSIGLVCARHLRMFEYEPTIFYPKRSTLGLHQDFTVQCEKMDIPFLSYLPTEVQLLNDAYNLVIDAILGPETDHKDVKEPYAGMLVTLKQVKIPIVSVDVPSGWDA-DEPAKD-GINPEVLISLTAPKKCATGFSGK-HFLAGRFLPYDIQKKYELNLPEF 237
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Match: rnf121 (ring finger protein 121 [Source:NCBI gene;Acc:394908])

HSP 1 Score: 391.349 bits (1004), Expect = 1.360e-132
Identity = 173/305 (56.72%), Postives = 233/305 (76.39%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+L+  ER ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FSIVTA + + ATRKP+  TTP  VY WFLL+YK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ IG+Y+ SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DLSELAPEERWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHQRSYNMVTLFQMWIVPVYFTVKLHWWRFLGIWFLFSIVTAFVTYKATRKPLVQTTPRLVYKWFLLLYKMSYATGIVGYIAVMFTLFGLNLLFRIKPEDAMDFGISLLFYGLYYGVLGRDFAEMCADYMASTIGFYSASGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYCLGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Match: rnf121 (ring finger protein 121 [Source:NCBI gene;Acc:394908])

HSP 1 Score: 337.421 bits (864), Expect = 1.150e-110
Identity = 151/267 (56.55%), Postives = 202/267 (75.66%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPW 1553
            DLS+L+  ER ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FSIVTA + + ATRKP+  TTP  VY WFLL+YK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ IG+Y+ SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NP+
Sbjct:   23 DLSELAPEERWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHQRSYNMVTLFQMWIVPVYFTVKLHWWRFLGIWFLFSIVTAFVTYKATRKPLVQTTPRLVYKWFLLLYKMSYATGIVGYIAVMFTLFGLNLLFRIKPEDAMDFGISLLFYGLYYGVLGRDFAEMCADYMASTIGFYSASGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPY 289
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Match: prkd1 (protein kinase D1 [Source:Xenbase;Acc:XB-GENE-487626])

HSP 1 Score: 275.789 bits (704), Expect = 5.388e-88
Identity = 132/237 (55.70%), Postives = 168/237 (70.89%), Query Frame = 3 
Query:   51 CRIIIIKRNIMSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            C+       +   ++YL+QEEA+ +D ELFNE+ FSVDQLMELAGLSCA AI +AYP+ +F+ +  ++L+ CGPGNNGGDGLVCARHLKLFGY+P I YPK+ +  LFENL  QC KM+IPF     S    ID +++ +VDA+FGFSFK  VR  F  I++ L    +PI S+DIPSGW+VE G    E I+P+ +ISLTAPK    +F G+ HFLGGRFVP  L  KY+LNLP Y
Sbjct:   47 CKQFRTGAAMERGLRYLSQEEAQAVDEELFNEYRFSVDQLMELAGLSCAVAITKAYPVSSFTSNLPTVLVVCGPGNNGGDGLVCARHLKLFGYEPAIHYPKRPNKTLFENLTTQCQKMDIPFVSEFPSEPEVIDGAYNLVVDAVFGFSFKGAVREPFGNILSTLKRVTVPIASVDIPSGWDVEKG--NPEGIQPDMLISLTAPKQSAVHFTGRYHFLGGRFVPKALEKKYSLNLPPY 281
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Match: tlk2 (tousled like kinase 2 [Source:Xenbase;Acc:XB-GENE-5747259])

HSP 1 Score: 188.734 bits (478), Expect = 3.671e-55
Identity = 90/221 (40.72%), Postives = 139/221 (62.90%), Query Frame = 3 
Query:  102 NQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFK-PPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            ++ EA+ ++ +L +++ F   QL+E+ G SCA A+ + YPL   +R   ++LI CGP  NG  GLVCAR+L+ + Y+P IFYPK+S   ++++L IQC KM+IPF     + +  I+++++ +VDA+ G   +   V+     I+  +    +PIIS+DIPSGW+ + G    E I PE +ISL APK C   F GK+HF+ GRF+P  +  K+ LN P Y
Sbjct:   22 DKNEAEALEADLLDDYRFGKQQLLEILGHSCAMAVTKVYPLKTLARKQPTVLIICGPEQNGAIGLVCARNLRSYDYEPTIFYPKRSLDVMYKDLTIQCEKMDIPFLSYLPTEVQLINDAYNLVVDAVLGIEAEFGEVKEPCASILTTMKQIKIPIISLDIPSGWDADAG--NPEGIYPEMLISLAAPKKCALQFTGKHHFIAGRFLPYDVQKKFELNSPVY 240
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Match: tlk2 (tousled like kinase 2 [Source:Xenbase;Acc:XB-GENE-5747259])

HSP 1 Score: 184.882 bits (468), Expect = 7.033e-54
Identity = 89/222 (40.09%), Postives = 138/222 (62.16%), Query Frame = 3 
Query:   99 LNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFK-PPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            L+  ++  ++ +L +++ F   QL+E+ G SCA A+ + YPL   +R   ++LI CGP  NG  GLVCAR+L+ + Y+P IFYPK+S   ++++L IQC KM+IPF     + +  I+++++ +VDA+ G   +   V+     I+  +    +PIIS+DIPSGW+ + G    E I PE +ISL APK C   F GK+HF+ GRF+P  +  K+ LN P Y
Sbjct:   14 LSSPDSFTLEADLLDDYRFGKQQLLEILGHSCAMAVTKVYPLKTLARKQPTVLIICGPEQNGAIGLVCARNLRSYDYEPTIFYPKRSLDVMYKDLTIQCEKMDIPFLSYLPTEVQLINDAYNLVVDAVLGIEAEFGEVKEPCASILTTMKQIKIPIISLDIPSGWDADAG--NPEGIYPEMLISLAAPKKCALQFTGKHHFIAGRFLPYDVQKKFELNSPVY 233
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Match: Rnf121 (ring finger protein 121 [Source:MGI Symbol;Acc:MGI:1922462])

HSP 1 Score: 388.267 bits (996), Expect = 1.806e-131
Identity = 172/305 (56.39%), Postives = 230/305 (75.41%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D+S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW  FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Match: Rnf121 (ring finger protein 121 [Source:MGI Symbol;Acc:MGI:1922462])

HSP 1 Score: 387.111 bits (993), Expect = 3.337e-131
Identity = 172/305 (56.39%), Postives = 230/305 (75.41%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D+S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW  FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:    6 DMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE 310
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Match: Rnf121 (ring finger protein 121 [Source:MGI Symbol;Acc:MGI:1922462])

HSP 1 Score: 384.415 bits (986), Expect = 2.790e-130
Identity = 171/304 (56.25%), Postives = 229/304 (75.33%), Query Frame = 3 
Query:  771 LSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW  FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:    1 MSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE 304
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Match: Naxe (NAD(P)HX epimerase [Source:MGI Symbol;Acc:MGI:2180167])

HSP 1 Score: 275.018 bits (702), Expect = 5.787e-88
Identity = 131/226 (57.96%), Postives = 164/226 (72.57%), Query Frame = 3 
Query:   84 SSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            ++VKYL+QEEA+ +D ELFNE+ FSVDQLMELAGLSCATAI +AYP  + S+   ++L+ CGPGNNGGDGLVCARHLKLFGY+P I+YPK+ +  LF  LV QC KM+IPF        + +D  ++ +VDA+FGFSFK  VR  F  I++ LS   +PI SIDIPSGW+VE G      I+P+ +ISLTAPK    +F G+ H+LGGRFVP  L  KY LNLP Y
Sbjct:   49 AAVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSKSPPTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFLGEMPPEPMMVDELYELVVDAIFGFSFKGDVREPFHSILSVLSGLTVPIASIDIPSGWDVEKG--NPSGIQPDLLISLTAPKKSATHFTGRYHYLGGRFVPPALEKKYQLNLPSY 272
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Match: Yjefn3 (YjeF N-terminal domain containing 3 [Source:MGI Symbol;Acc:MGI:2681845])

HSP 1 Score: 195.667 bits (496), Expect = 4.397e-58
Identity = 90/229 (39.30%), Postives = 140/229 (61.14%), Query Frame = 3 
Query:   93 KYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRL-----EFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEYT 764
            ++L+  EA  ++ EL  E+ F   QL+EL G + A A+ +A+PL + SR   ++L+ CGP  NG  GL CARHL++F Y+P IF P +S+  L  +L  QC KM+IPF     + +  ID+++  +VDA+ G    P VRL          +  L   ++P++S+D+PSGW+ E G    + ++P+ ++SL APK C   F G+ HF+ GRFVP+ +  K+ L+LP+YT
Sbjct:   19 RFLSASEAAALERELLEEYRFGRQQLVELCGHASAVAVTKAFPLPSLSRKQRTVLVVCGPEQNGAVGLACARHLRVFEYQPSIFCPARSADALHRDLTTQCEKMDIPFLSFLPAEVRLIDDAYGLVVDAVLG----PGVRLAEAGGHCARALATLKRLSIPLVSLDVPSGWDAEAGGDAKDAVQPDVLVSLAAPKSCAGRFSGRLHFVAGRFVPDDVRRKFGLHLPKYT 243
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Match: sp|Q6DD32|RN121_XENLA (RING finger protein 121 OS=Xenopus laevis OX=8355 GN=rnf121 PE=2 SV=1)

HSP 1 Score: 392.119 bits (1006), Expect = 3.637e-132
Identity = 173/305 (56.72%), Postives = 233/305 (76.39%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+L+  ER ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW VFSI+TA + + ATRKP+  TTP  VY WFLL+YK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ IG+Y+ SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DLSELAPEERWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHQRSYNMVTLFQMWIVPVYFTVKLHWWRFLGIWIVFSIITAYITYKATRKPLLQTTPRLVYKWFLLLYKMSYATGIVGYIAVMFTLFGLNLLFRIKPEDAMDFGISLLFYGLYYGVLGRDFAELCADYMASTIGFYSASGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYCLGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Match: sp|Q6P360|RN121_XENTR (RING finger protein 121 OS=Xenopus tropicalis OX=8364 GN=rnf121 PE=2 SV=1)

HSP 1 Score: 391.349 bits (1004), Expect = 7.205e-132
Identity = 173/305 (56.72%), Postives = 233/305 (76.39%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+L+  ER ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FSIVTA + + ATRKP+  TTP  VY WFLL+YK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ IG+Y+ SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DLSELAPEERWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHQRSYNMVTLFQMWIVPVYFTVKLHWWRFLGIWFLFSIVTAFVTYKATRKPLVQTTPRLVYKWFLLLYKMSYATGIVGYIAVMFTLFGLNLLFRIKPEDAMDFGISLLFYGLYYGVLGRDFAEMCADYMASTIGFYSASGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYCLGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Match: sp|Q9H920|RN121_HUMAN (RING finger protein 121 OS=Homo sapiens OX=9606 GN=RNF121 PE=1 SV=1)

HSP 1 Score: 389.808 bits (1000), Expect = 3.629e-131
Identity = 172/305 (56.39%), Postives = 231/305 (75.74%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D+S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW +FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGVVQGINYILGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Match: sp|Q8R1Z9|RN121_MOUSE (RING finger protein 121 OS=Mus musculus OX=10090 GN=Rnf121 PE=1 SV=1)

HSP 1 Score: 388.267 bits (996), Expect = 1.264e-130
Identity = 172/305 (56.39%), Postives = 230/305 (75.41%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D+S LS  E+ ++EH ++H +HRGHE MH EM LIL+  L++ Q LL+QW+QRH +S+   TL  MW+VP+  +    W+RF+ IW  FS VTA + F ATRKP+  TTP  VY WFLLIYK+SY  GIVGY+ +M TLFGLN+LF IKP  AMDFG  + FYGLY+GV+ RD + +C+D MA+ IG+Y++SG+PT+ L + VCAVCG ++  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   23 DMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWIFFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVNEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGISYILGLE 327
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Match: sp|Q8N4F7|RN175_HUMAN (RING finger protein 175 OS=Homo sapiens OX=9606 GN=RNF175 PE=1 SV=2)

HSP 1 Score: 360.918 bits (925), Expect = 5.918e-120
Identity = 159/303 (52.48%), Postives = 225/303 (74.26%), Query Frame = 3 
Query:  774 SKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEK-----FYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +KLS  +   L+  ++++ HRGH++MH+EM LI +  L+I Q +L+QWRQRH +S+   TL+ MW+VP+  +    W+RF+ +W +FS++T+ + F ATRKP++  TP  VY WFLLIYKLSY FG+VGYL IM T+ G N+ F IK   +MDFG +  FYGLY+GV+GRD + +CSD MA+ IG+Y+ S +PTR+L +++CAVCG K+  E  E+      Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RM  NPWE+ H LYG +LDW+RYLVAWQP++  I+ G+ ++ GL+
Sbjct:   26 TKLSAEDTWNLQQERMYKMHRGHDSMHVEMILIFLCVLVIAQIVLVQWRQRHGRSYNLVTLLQMWVVPLYFTIKLYWWRFLSMWGMFSVITSYILFRATRKPLSGRTPRLVYKWFLLIYKLSYAFGVVGYLAIMFTMCGFNLFFKIKARDSMDFGIVSLFYGLYYGVMGRDFAEICSDYMASTIGFYSVSRLPTRSLSDNICAVCGQKIIVELDEEGLIENTYQLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMISNPWERTHFLYGQILDWLRYLVAWQPVVIGIVQGIIYSLGLE 328
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Match: A0A267EM30 (RING-type domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig015028g1 PE=4 SV=1)

HSP 1 Score: 441.039 bits (1133), Expect = 9.478e-149
Identity = 194/311 (62.38%), Postives = 248/311 (79.74%), Query Frame = 3 
Query:  762 TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGN---KLDSEEK------EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            TYDL KLS  ER ++EH+ LHE+HRGHE+MH+EMF IL+  L++ Q LL+QWR+ + +S+Q ATL+GMW+VP+ +    SW RF+++W+VFS++T +M + ATRKP+A TTP RVYTWFLL YK+SY  GI GYLV+M  LFGL+ILFM+KP +AMDFG ++ FYGLYFGVV RD + VCSDKMA+ IGYYT++G+PTR LDE VCAVCG    + D +E       EK   LNC H+FHDFCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWEKPH+LYG+LLDW+RYLVAWQP+I  ++ G+ W  GL+
Sbjct:   18 TYDLDKLSPEERHRVEHLVLHEKHRGHESMHMEMFFILIATLVVAQILLVQWRKYYFQSYQTATLLGMWIVPVFLCLKLSWHRFLYVWSVFSVITGLMTYWATRKPLAGTTPRRVYTWFLLCYKMSYALGIAGYLVMMGALFGLSILFMVKPNVAMDFGLVLLFYGLYFGVVARDFAEVCSDKMASHIGYYTKTGMPTRKLDEGVCAVCGQPIVRQDEDEDGVSNGAEKVVVLNCAHSFHDFCIRGWCIVGKKQTCPYCKEKVDLKRMFPNPWEKPHILYGNLLDWIRYLVAWQPVIITLVQGINWALGLE 328
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Match: A0A1I8GT83 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 440.654 bits (1132), Expect = 1.062e-148
Identity = 194/311 (62.38%), Postives = 248/311 (79.74%), Query Frame = 3 
Query:  762 TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGN---KLDSEEK------EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            TYDL KLS  ER ++EH+ LHE+HRGHE+MH+EMF IL+  L++ Q LL+QWR+ + +S+Q ATL+GMW+VP+ +    SW RF+++W+VFS++T +M + ATRKP+A TTP RVYTWFLL YK+SY  GI GYLV+M  LFGL+ILFM+KP +AMDFG ++ FYGLYFGVV RD + VCSDKMA+ IGYYT++G+PTR LDE VCAVCG    + D +E       EK   LNC H+FHDFCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWEKPH+LYG+LLDW+RYLVAWQP+I  ++ G+ W  GL+
Sbjct:   16 TYDLDKLSPEERHRVEHLVLHEKHRGHESMHMEMFFILIATLVVAQILLVQWRKYYFQSYQTATLLGMWIVPVFLCLKLSWHRFLYVWSVFSVITGLMTYWATRKPLAGTTPRRVYTWFLLCYKMSYALGIAGYLVMMGALFGLSILFMVKPNVAMDFGLVLLFYGLYFGVVARDFAEVCSDKMASHIGYYTKTGMPTRKLDEGVCAVCGQPIVRQDEDEDGVSNGAEKVVVLNCAHSFHDFCIRGWCIVGKKQTCPYCKEKVDLKRMFPNPWEKPHILYGNLLDWIRYLVAWQPVIITLVQGINWALGLE 326
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Match: A0A1I8HFL6 (RING-type domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 440.269 bits (1131), Expect = 1.394e-148
Identity = 194/311 (62.38%), Postives = 248/311 (79.74%), Query Frame = 3 
Query:  762 TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGN---KLDSEEK------EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            TYDL KLS  ER ++EH+ LHE+HRGHE+MH+EMF IL+  L++ Q LL+QWR+ + +S+Q ATL+GMW+VP+ +    SW RF+++W+VFS++T +M + ATRKP+A TTP RVYTWFLL YK+SY  GI GYLV+M  LFGL+ILFM+KP +AMDFG ++ FYGLYFGVV RD + VCSDKMA+ IGYYT++G+PTR LDE VCAVCG    + D +E       EK   LNC H+FHDFCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWEKPH+LYG+LLDW+RYLVAWQP+I  ++ G+ W  GL+
Sbjct:   16 TYDLDKLSPEERHRVEHLVLHEKHRGHESMHMEMFFILIATLVVAQILLVQWRKYYFQSYQTATLLGMWIVPVFLCLKLSWHRFLYVWSVFSVITGLMTYWATRKPLAGTTPRRVYTWFLLCYKISYALGIAGYLVMMGALFGLSILFMVKPNVAMDFGLVLLFYGLYFGVVARDFAEVCSDKMASHIGYYTKTGMPTRKLDEGVCAVCGQPIVRQDEDEDGVSNGAEKVVVLNCAHSFHDFCIRGWCIVGKKQTCPYCKEKVDLKRMFPNPWEKPHILYGNLLDWIRYLVAWQPVIITLVQGINWALGLE 326
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Match: A0A1L8DSJ4 (Putative ring-containing e3 ubiquitin ligase OS=Nyssomyia neivai OX=330878 PE=4 SV=1)

HSP 1 Score: 402.134 bits (1032), Expect = 1.056e-133
Identity = 180/315 (57.14%), Postives = 240/315 (76.19%), Query Frame = 3 
Query:  741 NLNLP-EYTYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL---DSEEK--EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            NL+ P +    L +L+  E+ +LEHMKLHE+H+GHE+MH EM  IL+V L++ Q +L++W++RH KS+   TL+G+W++P+IIS  N W RFIF W +F+ +T I+   A  KP++ TTP  VY WF  IYKLSY  GIVGY+++M T FGLN +F   P + MD G +  FYGLY+GV+GRD+S +C+DKMAA IGYYT  G+PTR L+++VCAVCGN+L   +SEE   E  YKL+C H FH+FCIRGWCI+GKKQTCPYC+E+VDLQ++F NPWEKPH+LYG LLDW+R+LVAWQP I +I+HG+ W  GL+
Sbjct:    2 NLHEPVDLNKTLDELTSEEKLRLEHMKLHEKHKGHESMHAEMIFILLVTLVVAQVVLVEWKKRHYKSYSLVTLVGLWIIPLIISVRNEWLRFIFTWIIFTTITGIVMRKAIVKPISGTTPRLVYKWFYFIYKLSYALGIVGYIIMMMTFFGLNFVFNQAPHVWMDCGLMFVFYGLYYGVLGRDISEICADKMAAHIGYYTPQGMPTRNLEKNVCAVCGNQLLVGESEEGVLENTYKLSCEHVFHEFCIRGWCIVGKKQTCPYCKEKVDLQKIFCNPWEKPHVLYGQLLDWIRWLVAWQPFILLIVHGINWLLGLE 316
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Match: A0A0T6BAF6 (Zinc finger protein (Fragment) OS=Oryctes borbonicus OX=1629725 GN=AMK59_73 PE=4 SV=1)

HSP 1 Score: 399.823 bits (1026), Expect = 4.106e-133
Identity = 175/294 (59.52%), Postives = 234/294 (79.59%), Query Frame = 3 
Query:  801 KLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNK---LDSEEK--EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +LEH +LHE+H+GHE MH EM LIL+V L+I QF+LI+W++RH KS+   TL+ MW++P+ +S  N W+RF+FIW +FS +T ++   A  KP+  TTP  VY WFL IYKLSY  GI+GY+++M+TLFGLN++F  KP + +D G L  FYGLY+GV+GRD+S +C+DKMA+ +GYYT  G+PTR L+  VCAVCGN+   L++EE   E  YKL+CGHTFH+FCIRGWCI+GKKQTCPYC+E+VDL++MF NPWEKPH+LYG LLDW+R+LVAWQPLI  ++HG+ W+ GL+
Sbjct:    6 RLEHQRLHEQHKGHEAMHAEMVLILIVTLVIAQFVLIEWKRRHYKSYLLITLLAMWIIPLGLSIKNLWWRFVFIWLLFSCITGLIVRKALLKPIGGTTPRLVYKWFLFIYKLSYVLGIIGYIIMMATLFGLNLVFKAKPNVWLDCGLLFVFYGLYYGVLGRDISEICADKMASHVGYYTAQGMPTRNLEADVCAVCGNRLLVLENEEGIIENTYKLSCGHTFHEFCIRGWCIVGKKQTCPYCKEKVDLKKMFCNPWEKPHVLYGQLLDWIRWLVAWQPLILFLVHGINWSLGLE 299
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Match: RNF121 (ring finger protein 121 [Source:NCBI gene;Acc:103027590])

HSP 1 Score: 387.111 bits (993), Expect = 5.099e-131
Identity = 172/305 (56.39%), Postives = 233/305 (76.39%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+LS  E+ +LEH ++H +H+GHE MH EM LIL+V L+I Q +L+QW+QRH KS+   TL  MW+VP+  +    W+RF+  W +FS+VTA + F ATRKP+  TTP  VY WFLL+YK+SY  GIVGY V+M TLFG+N++F IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ +GYY+ SG+PT+ L + +CAVCG  +  D +E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   28 DLSQLSPEEKWRLEHARMHAKHKGHEAMHAEMVLILIVTLVIAQLVLVQWKQRHPKSYNLVTLFQMWVVPLYFTTKLHWWRFLVTWFIFSVVTAFITFRATRKPLECTTPRLVYKWFLLLYKISYTTGIVGYAVVMFTLFGINLIFRIKPEDAMDFGVSLLFYGLYYGVLGRDFAEMCADFMASTVGYYSASGMPTKHLSDSICAVCGQPILVDVDEEGIMENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYILGLE 332
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Match: RNF121 (ring finger protein 121 [Source:NCBI gene;Acc:103027590])

HSP 1 Score: 387.111 bits (993), Expect = 5.099e-131
Identity = 172/305 (56.39%), Postives = 233/305 (76.39%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DLS+LS  E+ +LEH ++H +H+GHE MH EM LIL+V L+I Q +L+QW+QRH KS+   TL  MW+VP+  +    W+RF+  W +FS+VTA + F ATRKP+  TTP  VY WFLL+YK+SY  GIVGY V+M TLFG+N++F IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ +GYY+ SG+PT+ L + +CAVCG  +  D +E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I  ++ G+ +  GL+
Sbjct:   28 DLSQLSPEEKWRLEHARMHAKHKGHEAMHAEMVLILIVTLVIAQLVLVQWKQRHPKSYNLVTLFQMWVVPLYFTTKLHWWRFLVTWFIFSVVTAFITFRATRKPLECTTPRLVYKWFLLLYKISYTTGIVGYAVVMFTLFGINLIFRIKPEDAMDFGVSLLFYGLYYGVLGRDFAEMCADFMASTVGYYSASGMPTKHLSDSICAVCGQPILVDVDEEGIMENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGLVQGINYILGLE 332
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Match: rnf175 (RING finger protein 175-like [Source:NCBI gene;Acc:103046747])

HSP 1 Score: 370.163 bits (949), Expect = 1.128e-124
Identity = 165/305 (54.10%), Postives = 224/305 (73.44%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNK--LDSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            D  K+S  E  K++H KLH +HRGHE MH EM LIL+  L++ Q +L+QW+QRH +S+   TL+ MW+VP+  +    W+RF+  W +FS++T+ + F ATRKP+++ TP  VY WFLLIYKLSY  G+ GYL IM T+FG N+ F IK   +MD G ++ FYGLY+GV+GRD + +CSD MA+ IGYY   G+P+R L   +CAVCG K  +D +E+   E  Y+L+C H FH+FCIRGWCI+GKKQTCPYC E+VDL+RM  NPWE+ H+LYG LLDW+RYLVAWQP+I  ++HG+ ++ GL+
Sbjct:    9 DPLKMSYRENWKVQHEKLHVKHRGHEAMHAEMVLILIATLVVAQIVLVQWKQRHCRSYNMVTLLQMWVVPLYFTIKLYWWRFLSTWGMFSVITSYVIFRATRKPLSVRTPRMVYKWFLLIYKLSYAVGVFGYLAIMFTMFGFNVFFRIKAEDSMDVGVIMLFYGLYYGVMGRDFAEICSDYMASTIGYYNVGGMPSRNLSHDICAVCGQKTFVDVDEEGIIEDTYQLSCNHIFHEFCIRGWCIVGKKQTCPYCNEKVDLKRMMNNPWERTHVLYGQLLDWLRYLVAWQPIIIGVVHGINFSLGLE 313
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Match: naxe (NAD(P)HX epimerase [Source:NCBI gene;Acc:103042906])

HSP 1 Score: 270.781 bits (691), Expect = 1.852e-86
Identity = 129/229 (56.33%), Postives = 166/229 (72.49%), Query Frame = 3 
Query:   75 NIMSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
             + +S+KYL QEEA+ ID ELF+E+SFSVDQLMELAGLSCATA+ + YPL +  +    +L+ CGPGNNGGDGLVCARHLKLFGY+P + YPK+ + +LF+NL  QC KMEIP           ID  ++ +VDA+FGFSFK  VR  F  I++ L   ++PI S+DIPSGW+VE G    + I+P+ +ISLTAPK   ++FKG+ H+LGGRFVP  L  KY+L LPEY
Sbjct:   46 TMANSIKYLGQEEAQRIDEELFSEYSFSVDQLMELAGLSCATAVTKGYPLQSLIKSPPRVLVICGPGNNGGDGLVCARHLKLFGYEPSVLYPKRPNKQLFQNLTTQCEKMEIPLLSGLPEAD-EIDEVYNVVVDAVFGFSFKGAVREPFGDILSTLKKISIPIASVDIPSGWDVELG--GRDGIQPDMLISLTAPKKAAEHFKGRYHYLGGRFVPPALEKKYSLRLPEY 271
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Match: naxe (NAD(P)HX epimerase [Source:NCBI gene;Acc:103042906])

HSP 1 Score: 270.781 bits (691), Expect = 1.852e-86
Identity = 129/229 (56.33%), Postives = 166/229 (72.49%), Query Frame = 3 
Query:   75 NIMSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
             + +S+KYL QEEA+ ID ELF+E+SFSVDQLMELAGLSCATA+ + YPL +  +    +L+ CGPGNNGGDGLVCARHLKLFGY+P + YPK+ + +LF+NL  QC KMEIP           ID  ++ +VDA+FGFSFK  VR  F  I++ L   ++PI S+DIPSGW+VE G    + I+P+ +ISLTAPK   ++FKG+ H+LGGRFVP  L  KY+L LPEY
Sbjct:   46 TMANSIKYLGQEEAQRIDEELFSEYSFSVDQLMELAGLSCATAVTKGYPLQSLIKSPPRVLVICGPGNNGGDGLVCARHLKLFGYEPSVLYPKRPNKQLFQNLTTQCEKMEIPLLSGLPEAD-EIDEVYNVVVDAVFGFSFKGAVREPFGDILSTLKKISIPIASVDIPSGWDVELG--GRDGIQPDMLISLTAPKKAAEHFKGRYHYLGGRFVPPALEKKYSLRLPEY 271
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Sea Lamprey
Match: naxe (NAD(P)HX epimerase [Source:NCBI gene;Acc:436891])

HSP 1 Score: 271.166 bits (692), Expect = 8.133e-88
Identity = 131/225 (58.22%), Postives = 165/225 (73.33%), Query Frame = 3 
Query:   90 VKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPS-GWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            +  ++QEEA+ ID ELFNE+ FSVDQLMELAGLSCATAI +AYPL+ F     ++LI CGPGNNGGDGLVCARHLKLFGY+P IFYPK+ +  LF+ L  QC +M+IPF     + +  +++++  +VDA+FGFSF   VR  F  I+  L   N+PIISID+PS GW+VE G    + I+P+ +ISLTAPK   ++F GK HFLGGRFVP  LA KYNL LPEY
Sbjct:   15 IPIISQEEAQAIDQELFNEYRFSVDQLMELAGLSCATAIAKAYPLETFPAKKHTLLIICGPGNNGGDGLVCARHLKLFGYEPTIFYPKRPNKPLFQALTTQCERMDIPFLSYLPTQVQLLNDAYSLVVDAIFGFSFSGEVREPFGTILTTLKQVNMPIISIDVPSEGWDVEAG--NPDGIQPQMLISLTAPKRAARHFHGKYHFLGGRFVPPDLARKYNLTLPEY 237
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Yeast
Match: NNR1 (NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005144])

HSP 1 Score: 187.963 bits (476), Expect = 3.844e-56
Identity = 98/233 (42.06%), Postives = 140/233 (60.09%), Query Frame = 3 
Query:   81 MSSVKYLNQEEAKNIDLELFN-EFSFSVDQLMELAGLSCATAIHQAYPL--DNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSS-GKLFENLVIQCNKMEIPFTENSESFILSI--DNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTN--LPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKN--HFLGGRFVPNKLALKYNLN 749
            MS++K ++ + A  ID EL   +  F++ QLMELAG S A A+ + +PL     +     + +  GPGNNGGDGLVCARHLKLFGY PV+FYPK+S   + ++ LV Q N  ++P     E   L          IVDA+FGFSFKPP+R  F+ I+ +L      +PI+S+D+P+GW+V+ GP+    I P  ++SLT PK C  + +     H++GGRF+P   A K+   
Sbjct:    1 MSTLKVVSSKLAAEIDKELMGPQIGFTLQQLMELAGFSVAQAVCRQFPLRGKTETEKGKHVFVIAGPGNNGGDGLVCARHLKLFGYNPVVFYPKRSERTEFYKQLVHQLNFFKVPVLSQDEGNWLEYLKPEKTLCIVDAIFGFSFKPPMREPFKGIVEELCKVQNIIPIVSVDVPTGWDVDKGPISQPSINPAVLVSLTVPKPCSSHIRENQTTHYVGGRFIPRDFANKFGFE 233
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Nematostella
Match: EDO40435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S753])

HSP 1 Score: 370.163 bits (949), Expect = 2.137e-125
Identity = 157/279 (56.27%), Postives = 221/279 (79.21%), Query Frame = 3 
Query:  801 KLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCG-----NKLDSEEK-EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQP 1619
            ++EH KLH +H+GHE MH+EM LIL   LI+ Q +L++W++ H KS+Q  TL+GMWL+P+  +    ++R + +WTVFS+ TA + + ATR+P++ TTP  VY WF  ++K++Y  GI GYLVIM TL GLN++FM++P  +M+FG ++ FYGLY+GV+GRD + +CSDKMA++IGYY+ +G+P+R+L+ ++CAVCG     N +D +E  EK YKL+CGH FH+FCIRGWCI+GKKQTCPYC+E+VDL+RMF NPWE+PH+L+G LLDW+RYLV WQP
Sbjct:    1 RIEHEKLHAKHKGHEAMHMEMVLILFATLIVAQIVLVKWKKMHFKSYQTVTLVGMWLIPVYFNVKLHYWRMMAVWTVFSLATAFIVYKATRQPVSTTTPRLVYKWFYSVHKVTYALGIAGYLVIMFTLLGLNLMFMVRPETSMEFGIVVMFYGLYYGVLGRDFAEICSDKMASKIGYYSTTGLPSRSLETNICAVCGQHLIINTVDEDEMPEKTYKLSCGHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFCNPWERPHVLFGQLLDWLRYLVVWQP 279
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Nematostella
Match: EDO46631 (NAD(P)H-hydrate epimerase [Source:UniProtKB/Swiss-Prot;Acc:A7RPT4])

HSP 1 Score: 241.506 bits (615), Expect = 1.907e-76
Identity = 124/224 (55.36%), Postives = 161/224 (71.88%), Query Frame = 3 
Query:   90 VKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            ++YLNQ EA+NID ELFNE++FSVDQLMELAGLS A AI +AYP    +     +L+C GPGNNGGDGLV ARHLK+FGY+P I+YPK+ +  L  NLV QC KMEI F  +  S    ++  +  +VDA+FGFSFK  VR  F+ ++  L N  +P+ ++D+PSGW+VE G    E I+PE +ISLTAPKLC  +FKG+ H+LGGRFVP+ L  KY L LP++
Sbjct:    1 MRYLNQSEAQNIDQELFNEYAFSVDQLMELAGLSVAVAISKAYPR---TGDGERLLVCSGPGNNGGDGLVAARHLKMFGYQPEIYYPKRPNRTLMNNLVTQCEKMEISFLTDLPS-AQEMNFKYRLVVDAIFGFSFKGEVRAPFDDVLKTLKNVKIPLCAVDVPSGWDVEKG--NPEGIQPEFLISLTAPKLCANHFKGRFHYLGGRFVPDLLLKKYELELPDF 218
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Medaka
Match: rnf121 (RING finger protein 121 [Source:NCBI gene;Acc:101155951])

HSP 1 Score: 385.185 bits (988), Expect = 2.663e-130
Identity = 169/306 (55.23%), Postives = 233/306 (76.14%), Query Frame = 3 
Query:  765 YDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            +D+SKLS  E+ ++EH K+H +H+GHE MH EM LIL+V L++ Q +L+QW+QRH KS+   TL  MW+VP+  +    W+RF+  W VFS++TA ++F ATRKP+A TTP  VY WFLL+YK+SY  GI GY ++M TLFG+N++F IKP  AMDFG  + FYGLY+GV+GRD + +C+D MA+ +GYY+ SG+PT+ L +++CAVCG  +  D  E+   E  Y+L+C H FH+FCIRGWCI+GKKQ CPYC+E+VDL+RMF NPWE+PH++YG LLDW+RYLVAWQP+I   + G+ +  GL+
Sbjct:   27 FDVSKLSPEEKWRMEHAKMHAKHKGHEAMHAEMVLILIVTLVVAQLVLVQWKQRHPKSYNLVTLFQMWVVPLYFTTKLHWWRFLTTWFVFSVITAYISFRATRKPLACTTPRLVYKWFLLLYKISYAIGIAGYSIVMFTLFGINLIFRIKPEDAMDFGVSLLFYGLYYGVLGRDFAEMCADFMASTVGYYSASGMPTKHLSDNICAVCGQPILVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQMCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGFVQGINYVLGLE 332
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Medaka
Match: rnf175 (ring finger protein 175 [Source:NCBI gene;Acc:101173505])

HSP 1 Score: 382.104 bits (980), Expect = 2.789e-129
Identity = 169/305 (55.41%), Postives = 230/305 (75.41%), Query Frame = 3 
Query:  768 DLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKL--DSEEK---EKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            DL K++  E  KL+H +LH +HRGHE MH EM +IL+  L++ Q LL+QW+QRH +S+   TL+ MW+VP+  +    W+RF+ +W VFS+VT+ + F ATRKP++  TP  VY WFLLIYKLSY  G++GYL IM T+FG N+ F IK   +MD G ++ FYGLY+GV+GRD + +CSD MA+ IGYY++ G+P+R+L   +CAVCG ++  D EE+   E  Y+L+CGH FH+FCIRGWCI+GKKQTCPYC E+VDL+RM  NPWEK H+LYG LLDW+RYLVAWQP+I  ++HG+ ++ GL+
Sbjct:   10 DLLKMTHRENWKLQHERLHLKHRGHEAMHAEMVMILIATLVVAQILLVQWKQRHHRSYNLVTLVQMWVVPLYFTLKLYWWRFLSMWGVFSVVTSYVIFRATRKPLSCRTPRMVYKWFLLIYKLSYAVGVLGYLAIMFTMFGFNVFFRIKAEDSMDVGVVMLFYGLYYGVMGRDFAEICSDYMASTIGYYSKGGMPSRSLSSDICAVCGQRILVDVEEEGFIEDTYQLSCGHIFHEFCIRGWCIVGKKQTCPYCNEKVDLKRMMNNPWEKTHVLYGQLLDWLRYLVAWQPIIIGVVHGINFSLGLE 314
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Medaka
Match: naxe (NAD(P)HX epimerase [Source:NCBI gene;Acc:101160006])

HSP 1 Score: 280.026 bits (715), Expect = 4.730e-90
Identity = 133/226 (58.85%), Postives = 169/226 (74.78%), Query Frame = 3 
Query:   87 SVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPF-TENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            S+KYL QEEA++ID ELF+E+ FSVDQLMELAGLSCATA+ +AYP+ + ++   ++L+ CGPGNNGGDGLVCARHLKLFGY+P I YPK+ +  LF+ L  QC KMEIPF TE  E  +  ID +++ ++DA+FGFSFK  VR  F  I++ L  T +PI SIDIPSGW+VE G  +   ++P+T+ISLTAPK     F+G+ HFLGGRFVP  L  KY LNLP Y
Sbjct:   52 SIKYLGQEEAQHIDEELFSEYGFSVDQLMELAGLSCATAVARAYPVASLTKARPTLLVVCGPGNNGGDGLVCARHLKLFGYEPTILYPKRPNKPLFQGLTTQCQKMEIPFLTEMPEVDV--IDEAYNLVIDAIFGFSFKGSVREPFGSILDVLKKTTVPIASIDIPSGWDVEQGAADG--LQPDTLISLTAPKKAASMFRGRYHFLGGRFVPPSLERKYQLNLPPY 273
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Medaka
Match: yjefn3 (YjeF N-terminal domain containing 3 [Source:NCBI gene;Acc:101166862])

HSP 1 Score: 185.267 bits (469), Expect = 3.280e-54
Identity = 87/225 (38.67%), Postives = 140/225 (62.22%), Query Frame = 3 
Query:   90 VKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFK-PPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            ++YL++ EA  I+ EL  ++ F   QL+EL G +CA AI +AYPL + ++   ++L+ CGP   G  GLVCARHL++F ++P +++PK S   L ++  +QC KM+IPF     + +  I+++++ ++DA+ G       ++  +  I+  L    +PI S+D+PSGW+ E+     + I P+ +ISL APK C   F GK HFL GRF+P  +  KY LNLP++
Sbjct:   17 LRYLSKGEAAAIEAELLRDYRFGQQQLIELWGQACALAIAKAYPLSSLTKKQPTVLVICGPEQKGSIGLVCARHLRMFNFEPTVYHPKHSPHSLHQDFTVQCEKMDIPFLSYLPTEVQLINDAYNLVIDAMLGPEADCSNIKEPYSGILVTLKQVRIPIASVDVPSGWDAEEA--NQDGINPDALISLMAPKKCASAFLGK-HFLVGRFLPYDIQKKYELNLPDF 238
[Close]
BLAST of NAD(P)H-hydrate epimerase vs. Planmine SMEST
Match: SMESG000022790.1 (SMESG000022790.1)

HSP 1 Score: 632.098 bits (1629), Expect = 0.000e+0
Identity = 304/314 (96.82%), Postives = 307/314 (97.77%), Query Frame = 3 
Query:  726 LALKYNLNLPEYTYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            + L+  L +   TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK
Sbjct:    1 MTLENILVINNKTYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 314
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BLAST of NAD(P)H-hydrate epimerase vs. Planmine SMEST
Match: SMESG000022790.1 (SMESG000022790.1)

HSP 1 Score: 631.328 bits (1627), Expect = 0.000e+0
Identity = 302/302 (100.00%), Postives = 302/302 (100.00%), Query Frame = 3 
Query:  762 TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 1667
            TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK
Sbjct:   19 TYDLSKLSDIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLKSFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMAMTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDFGFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAVCGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQRMFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK 320
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BLAST of NAD(P)H-hydrate epimerase vs. Planmine SMEST
Match: SMESG000022789.1 (SMESG000022789.1)

HSP 1 Score: 467.618 bits (1202), Expect = 3.054e-164
Identity = 226/227 (99.56%), Postives = 226/227 (99.56%), Query Frame = 3 
Query:   81 MSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 761
            MSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFI SIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY
Sbjct:    1 MSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAGLSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKPVIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFISSIDNSFDAIVDALFGFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPETIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEY 227
The following BLAST results are available for this feature:
BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RNF1217.556e-13256.39ring finger protein 121 [Source:HGNC Symbol;Acc:HG... [more]
RNF1211.813e-12856.80ring finger protein 121 [Source:HGNC Symbol;Acc:HG... [more]
RNF1751.232e-12052.48ring finger protein 175 [Source:HGNC Symbol;Acc:HG... [more]
NAXE4.221e-8758.01NAD(P)HX epimerase [Source:HGNC Symbol;Acc:HGNC:18... [more]
RNF1212.069e-6655.68ring finger protein 121 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
rnf-1213.778e-11649.36RING finger protein 121 [Source:UniProtKB/Swiss-P... [more]
Y18D10A.33.891e-5646.93NAD(P)H-hydrate epimerase [Source:UniProtKB/Swiss... [more]
toe-41.453e-644.44Target Of ERK kinase MPK-1 [Source:UniProtKB/TrEM... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG158143.632e-13056.72gene:FBgn0030873 transcript:FBtr0074468[more]
CG158143.632e-13056.72gene:FBgn0030873 transcript:FBtr0074470[more]
CG158143.632e-13056.72gene:FBgn0030873 transcript:FBtr0074469[more]
CG158141.121e-12957.91gene:FBgn0030873 transcript:FBtr0074471[more]
Naxe3.629e-8556.00gene:FBgn0030178 transcript:FBtr0290234[more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1213.556e-13055.74ring finger protein 121 [Source:ZFIN;Acc:ZDB-GENE-... [more]
rnf1753.657e-12754.75ring finger protein 175 [Source:ZFIN;Acc:ZDB-GENE-... [more]
rnf1754.947e-12554.49ring finger protein 175 [Source:ZFIN;Acc:ZDB-GENE-... [more]
naxe2.672e-8859.03NAD(P)HX epimerase [Source:NCBI gene;Acc:436891][more]
yjefn31.396e-5740.35YjeF N-terminal domain containing 3 [Source:ZFIN;A... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1211.360e-13256.72ring finger protein 121 [Source:NCBI gene;Acc:3949... [more]
rnf1211.150e-11056.55ring finger protein 121 [Source:NCBI gene;Acc:3949... [more]
prkd15.388e-8855.70protein kinase D1 [Source:Xenbase;Acc:XB-GENE-4876... [more]
tlk23.671e-5540.72tousled like kinase 2 [Source:Xenbase;Acc:XB-GENE-... [more]
tlk27.033e-5440.09tousled like kinase 2 [Source:Xenbase;Acc:XB-GENE-... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rnf1211.806e-13156.39ring finger protein 121 [Source:MGI Symbol;Acc:MGI... [more]
Rnf1213.337e-13156.39ring finger protein 121 [Source:MGI Symbol;Acc:MGI... [more]
Rnf1212.790e-13056.25ring finger protein 121 [Source:MGI Symbol;Acc:MGI... [more]
Naxe5.787e-8857.96NAD(P)HX epimerase [Source:MGI Symbol;Acc:MGI:2180... [more]
Yjefn34.397e-5839.30YjeF N-terminal domain containing 3 [Source:MGI Sy... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6DD32|RN121_XENLA3.637e-13256.72RING finger protein 121 OS=Xenopus laevis OX=8355 ... [more]
sp|Q6P360|RN121_XENTR7.205e-13256.72RING finger protein 121 OS=Xenopus tropicalis OX=8... [more]
sp|Q9H920|RN121_HUMAN3.629e-13156.39RING finger protein 121 OS=Homo sapiens OX=9606 GN... [more]
sp|Q8R1Z9|RN121_MOUSE1.264e-13056.39RING finger protein 121 OS=Mus musculus OX=10090 G... [more]
sp|Q8N4F7|RN175_HUMAN5.918e-12052.48RING finger protein 175 OS=Homo sapiens OX=9606 GN... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267EM309.478e-14962.38RING-type domain-containing protein (Fragment) OS=... [more]
A0A1I8GT831.062e-14862.38RING-type domain-containing protein OS=Macrostomum... [more]
A0A1I8HFL61.394e-14862.38RING-type domain-containing protein OS=Macrostomum... [more]
A0A1L8DSJ41.056e-13357.14Putative ring-containing e3 ubiquitin ligase OS=Ny... [more]
A0A0T6BAF64.106e-13359.52Zinc finger protein (Fragment) OS=Oryctes borbonic... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RNF1215.099e-13156.39ring finger protein 121 [Source:NCBI gene;Acc:1030... [more]
RNF1215.099e-13156.39ring finger protein 121 [Source:NCBI gene;Acc:1030... [more]
rnf1751.128e-12454.10RING finger protein 175-like [Source:NCBI gene;Acc... [more]
naxe1.852e-8656.33NAD(P)HX epimerase [Source:NCBI gene;Acc:103042906... [more]
naxe1.852e-8656.33NAD(P)HX epimerase [Source:NCBI gene;Acc:103042906... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
naxe8.133e-8858.22NAD(P)HX epimerase [Source:NCBI gene;Acc:436891][more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
NNR13.844e-5642.06NADHX epimerase; catalyzes isomerization of (R)- a... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO404352.137e-12556.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO466311.907e-7655.36NAD(P)H-hydrate epimerase [Source:UniProtKB/Swiss... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
rnf1212.663e-13055.23RING finger protein 121 [Source:NCBI gene;Acc:1011... [more]
rnf1752.789e-12955.41ring finger protein 175 [Source:NCBI gene;Acc:1011... [more]
naxe4.730e-9058.85NAD(P)HX epimerase [Source:NCBI gene;Acc:101160006... [more]
yjefn33.280e-5438.67YjeF N-terminal domain containing 3 [Source:NCBI g... [more]
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BLAST of NAD(P)H-hydrate epimerase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000022790.10.000e+096.82SMESG000022790.1[more]
SMESG000022790.10.000e+0100.00SMESG000022790.1[more]
SMESG000022789.13.054e-16499.56SMESG000022789.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021937 ID=SMED30021937|Name=NAD(P)H-hydrate epimerase|organism=Schmidtea mediterranea sexual|type=transcript|length=1753bp
CTGTTTTAAATCTTTAAATAACCTTGTATTTTTGAATGCTAAAAACTTTT
TGTAGGATTATTATTATTAAACGTAATATCATGTCAAGTGTCAAGTATTT
AAATCAAGAAGAAGCAAAAAATATAGATTTAGAATTATTCAATGAGTTCT
CGTTTAGTGTTGACCAATTAATGGAATTAGCAGGACTCAGTTGTGCTACC
GCTATACACCAAGCGTATCCTCTTGATAACTTTTCTCGACATAATGGTTC
AATCCTCATCTGCTGCGGGCCAGGTAACAATGGGGGTGATGGGTTGGTGT
GTGCAAGACATTTAAAGCTCTTCGGATATAAGCCTGTTATATTCTATCCT
AAAAAATCCAGCGGAAAATTGTTTGAAAATCTTGTGATACAATGCAACAA
AATGGAAATTCCTTTCACTGAAAATTCCGAATCATTTATTTTATCTATTG
ATAACTCTTTTGACGCTATTGTCGATGCTCTATTCGGATTTAGTTTCAAA
CCGCCCGTTAGACTGGAATTTGAACCAATCATTAACAAGCTTTCTAATAC
CAATTTGCCTATTATTAGCATTGATATACCTTCAGGTTGGAATGTTGAGG
ATGGTCCGGTCGAAAATGAACACATAAAACCCGAAACAATTATTTCACTT
ACAGCTCCAAAGCTATGCGTAAAATATTTTAAAGGAAAGAACCATTTTCT
AGGTGGAAGATTTGTCCCCAACAAACTAGCATTGAAATACAACTTGAATC
TACCAGAATATACCTATGATCTCAGTAAATTGTCTGATATCGAGCGAAGA
AAACTGGAGCACATGAAGTTGCATGAAGAACATAGGGGGCATGAAACAAT
GCATTTAGAAATGTTTTTAATTCTAGTTGTGTGCCTTATAATTACCCAAT
TCTTACTGATACAATGGCGACAGAGGCACCTGAAATCGTTTCAGCAAGCG
ACTCTTATCGGCATGTGGCTTGTCCCAATGATAATCAGTTTTTATAACTC
GTGGTTTCGATTTATATTTATCTGGACAGTCTTTTCAATAGTCACTGCCA
TCATGGCATTCGCAGCTACAAGGAAACCAATGGCAATGACCACACCAAGC
CGGGTCTACACGTGGTTCTTATTGATCTATAAACTTAGTTATTTCTTTGG
TATTGTCGGTTATTTGGTCATTATGTCAACTTTATTTGGATTGAATATTT
TATTCATGATAAAACCCGGAATTGCAATGGATTTCGGATTTCTGATTACT
TTCTATGGGCTTTATTTTGGTGTTGTTGGTAGAGATCTTTCGGCTGTGTG
TAGTGATAAAATGGCGGCTCAGATTGGGTATTATACGCAAAGTGGTGTTC
CAACAAGGACACTCGATGAACACGTATGTGCTGTTTGTGGTAATAAATTG
GATTCAGAAGAAAAGGAAAAGTTTTACAAACTCAATTGTGGTCACACATT
CCATGATTTCTGTATTCGAGGCTGGTGTATTATTGGTAAAAAACAGACTT
GCCCATATTGTCGAGAAAGGGTAGATCTACAAAGGATGTTTAAAAATCCC
TGGGAAAAGCCGCATTTACTTTATGGAAGCTTGCTGGATTGGGTGCGATA
TTTAGTAGCTTGGCAGCCTTTAATATTTGTTATAATTCACGGAGTTTTTT
GGACATTTGGTTTAAAATAAAATCTTAGTTTTGTTTTTCAAACACTATTT
TCAATTTTGTGAGTTTTAATTTTTATTATTTGACTTTTTCTAGTTATTTG
AGG
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protein sequence of SMED30021937-orf-1

>SMED30021937-orf-1 ID=SMED30021937-orf-1|Name=SMED30021937-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=545bp
MLKTFCRIIIIKRNIMSSVKYLNQEEAKNIDLELFNEFSFSVDQLMELAG
LSCATAIHQAYPLDNFSRHNGSILICCGPGNNGGDGLVCARHLKLFGYKP
VIFYPKKSSGKLFENLVIQCNKMEIPFTENSESFILSIDNSFDAIVDALF
GFSFKPPVRLEFEPIINKLSNTNLPIISIDIPSGWNVEDGPVENEHIKPE
TIISLTAPKLCVKYFKGKNHFLGGRFVPNKLALKYNLNLPEYTYDLSKLS
DIERRKLEHMKLHEEHRGHETMHLEMFLILVVCLIITQFLLIQWRQRHLK
SFQQATLIGMWLVPMIISFYNSWFRFIFIWTVFSIVTAIMAFAATRKPMA
MTTPSRVYTWFLLIYKLSYFFGIVGYLVIMSTLFGLNILFMIKPGIAMDF
GFLITFYGLYFGVVGRDLSAVCSDKMAAQIGYYTQSGVPTRTLDEHVCAV
CGNKLDSEEKEKFYKLNCGHTFHDFCIRGWCIIGKKQTCPYCRERVDLQR
MFKNPWEKPHLLYGSLLDWVRYLVAWQPLIFVIIHGVFWTFGLK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0052856NADHX epimerase activity
GO:0052857NADPHX epimerase activity
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0000166nucleotide binding
GO:0003674molecular_function
GO:0016853isomerase activity
GO:0046872metal ion binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000204ovary
PLANA:0000208testis
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR036652YjeF_N_dom_sf
IPR040176RNF121/RNF175
IPR001841Znf_RING
IPR013083Znf_RING/FYVE/PHD
IPR004443YjeF_N_dom
Vocabulary: cellular component
TermDefinition
GO:0005575cellular_component
Vocabulary: biological process
TermDefinition
GO:0008150biological_process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001841Zinc finger, RING-typeSMARTSM00184ring_2coord: 448..492
e-value: 4.2E-4
score: 29.6
IPR001841Zinc finger, RING-typePFAMPF13639zf-RING_2coord: 447..493
e-value: 3.9E-7
score: 30.3
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 448..493
score: 12.578
IPR004443YjeF N-terminal domainPFAMPF03853YjeF_Ncoord: 43..211
e-value: 1.6E-36
score: 125.8
IPR004443YjeF N-terminal domainTIGRFAMTIGR00197TIGR00197coord: 24..227
e-value: 1.7E-46
score: 156.4
IPR004443YjeF N-terminal domainPROSITEPS51385YJEF_Ncoord: 27..239
score: 58.832
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 445..504
e-value: 2.0E-13
score: 51.6
IPR036652YjeF N-terminal domain superfamilyGENE3DG3DSA:3.40.50.10260coord: 18..257
e-value: 8.8E-87
score: 292.3
IPR036652YjeF N-terminal domain superfamilySUPERFAMILYSSF64153YjeF N-terminal domain-likecoord: 20..243
IPR040176RING finger protein RNF121/RNF175PANTHERPTHR13407RNF121 PROTEINcoord: 243..544
NoneNo IPR availableCDDcd16475RING-H2_RNF121_likecoord: 446..495
e-value: 2.57245E-27
score: 101.983
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 438..503
NoneNo IPR availableTMHMMTMhelixcoord: 270..292
NoneNo IPR availableTMHMMTMhelixcoord: 326..345
NoneNo IPR availableTMHMMTMhelixcoord: 305..322
NoneNo IPR availableTMHMMTMhelixcoord: 358..380
NoneNo IPR availableTMHMMTMhelixcoord: 395..414
NoneNo IPR availableTMHMMTMhelixcoord: 519..541