Guanylate cyclase

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKTA +KGNLVA+K +N   +IE+T ++L E+K ++D+ N+H+ RF+G C D P   I+ EYCP+GSL+D+L  E I LDWMF+YSL  DI +GM++LHN     HGNLKSSNC+VD RFVLKITD+GL S +    ++  E+ +  Y   LWTAPELL +++PPV G+  GDVYSF +I QEI  R+GVF +    +L+ KEI E+V   + PPFRP+L L     +++  L+Q+ W EDP  RP F  I+L +RK N+  ++ NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH+ E+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S  TK +L+ FG F +  RG +++KGKG   TYWL GE
Sbjct:  541 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVE-GLDLSPKEIIERVTRGEQPPFRPSLALQSHL-EELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054          

Query:  220 LLLPKNFSTFPW--ALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISA----GVMGAFVAIAI-IGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP   +++PW  A   P++++ L +V+   ++ P      +L   ++    C  T  PL    + + +  P V  GP C Y  AP+ R  A W  P++T GA    F      E+   TR G  +     G  ++ L  +  W +   + +  AY      +C     +LV+G    V++  + +  + H    ++D +    L+  +  K  +  +C+ PD  R +ML A        +Y+F ++DIF             RPW R D    ++  A++AF+    IT + P+  +Y EF  ++K  A  ++NFT E+ LVN+  +SFHD ++LY   + +TL+ GG + DGE + + MWNRSF+ +   + I   GDR  DFSL D++ + G F VV NY G  ++   V+ + ++W       P D P CG+D      P  N   +S      ++G+   + I I   FI+R+ + + EL +  W + W+D+E S   R   S G   
Sbjct:   39 VVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKW-EHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVK--DEYALTTRAGPSYAK--LGDFVAALHRRLGWERQALMLY--AYRPGDEEHC----FFLVEGLFMRVRD-RLNITVD-HLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGD---GQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPL--GYPPPDIPKCGFDNE---DPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRL 531          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  + I LDWMF+YSL+ D+ +GM +LHN+    HG+LKSSNC+VDSRFVLKITD+GL S +   +    ++ +  Y   LWTAPELL+ +  P  G  K DVYSF +I QEI  R+G F L    +L+ KEI +KVRN   P FRP++  T    ++++ L+++ W +DP  RPDF  IK  +R+ NK G T +ILDNLL RMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ EIARM++A L A+S F I HRP  +L LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TK+ LD  G F +  RG +++KGKG   TYWL GE
Sbjct:  533 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR---STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039          

Query:  187 VRP--NRDYPLAMLLLPKNFS-TFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFS 1740
            VRP   R+  LA++L   N S  + W    P++ + +E + +   ++    + +    ++  C +   PL    +    + PD++ GP C Y  A +AR  + W  P++T GA+   FS+ +   + TL R G        G  +  L   + W     + + DA     P Y      + ++G  + ++   + V  +++  +        +     I     I  +C   +++ +I+L+A   N  NG+Y+F  +D+F             RPW + +R  E+ +  ++AF+T++ IT R+P   +Y+EF   +  RA+ ++       L+N     F+D ++LYA  LN+T+ +GG  EDG  +V+ M  R +  +   V +  + DR  DF L  +    +G F+  ++Y G +++      + I W  V    P D P C +DL    C K   +  AI A   G    +  +    I R+   + EL +M W I W++L+        F + + +H     R +
Sbjct:   17 VRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSE----LEGACSEYLAPLSAVDLKLYHD-PDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSA-KNDHYRTLVRTGPSA--PKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHY------FTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHF----IRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIW-WTGRPIPW--VKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ--------FGNSERYHKGAGSRLT 516          

Query: 2092 DMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGT-FIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPV 3531
            D+ +++I   +G   D     IV E+C +GSLED+L  + +KLDWMFK SL+ D+ +GM YLH+    HG LKS NC+VD RFVLK+TD+G   +      +   E     +  LWTAPELL        G+  GDVYSFA+I QE++ R   F +    +L ++EI  ++  K  PP    ++  +    + L+L++Q W E    RP F  I    +  NKG  T NI+D++L  +EQY++NLE L+ +RTE+   EKQK E LL  MLP  VA  L K   V  E +D+VT++FSDIVGFT +SA S P+++++LLN LYT FD+II ++DVYKVETIGDAYMV SGLP+ NG+ H+ EIA MS+  L ++  F + H P+  + +RIG+HSGPV +GVVGL MPRYCLFGDTVNT+SRMES GLP +IH+S ST  IL      + +  RG  +LKGKG + T+WL G+    + PLPV
Sbjct:  600 DLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL---EMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMM---DLPAQEIINRL--KKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKT-NIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK-KGFMKPLPV 1072          

Query: 2149 IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGT-FIISERGHIDLKGKGLQLTYWLHGE 3501
            +V E+C +GSL+D+LA+ +IKLDWMFK SL+ D+ +G+ YLH+    HG LKS NC+VD RFVLKITD G   L      ++ E P    +  LWTAPELL        GT+ GDV+S A+I QE+V R+  +++     LT +E+ ++VR+   PP    L+  D    + + L++Q W E P  RP       L + +NKG  T NI+D++L  +EQY++NLE L+ +RTE+   EKQK + LL  MLP  VA  L     V  E ++ VT++FSDIVGFT +SA S P+++++LLN LYT FD+II ++DVYKVETIGDAYMV SGLPQ NG  H+ EIA MS+  L A+  F + H P+  + +RIG+HSGP  +GVVGL MPRYCLFGDTVNT+SRMES GLP +IH++ ST  IL    + + +  RG  +LKGKG + T+WL G 
Sbjct:  617 VVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLL-EAQKVLPEPPRA--EDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML---ELTPEEVVQRVRSP--PPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGR 1059          

Query: 2152 VYEYCPKGSLEDVLAK-----EQIKLDWMFKYSLMQDICRGMIYLHNNHGP-HGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDD--VLKLIQQAWDEDPTSRPDFATIKLLMRK---LNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILD-TFGTFIISERGHIDLKGKGLQLTYWLHG-EDSNIVDPLP 3528
            V EYC +GSL +VL       +   +DW FK S++ DI +GM YLH++    HG LKS+NC+VDSR V+KITDFG  S+   K +             LWTAPE L  +N     + KGDVYS+ +I QEI+ R   F  T      +++IF    +    PFRP L L      +  V  L++  W+EDP  RPDF  I+  + K   L       + +D L+ R++ Y+ NLE LV +RT+ Y  E+ +A+ L + +LP+ V   L +   V  E Y+ VTI+FSDIVGFT +   STPM+++++LN +Y +FD I++++DVYKVETIGDAYMV SGLP+ NGN H+ +IA+M++  L  +  F + H P   + +RIG+HSGP  +GVVG+KMPRYCLFGDTVNT+SRMES GLPL+IH+S ST  IL  T   F+   RG   LKG+G + TYWL G +D     P P
Sbjct:  560 VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKD-------------LWTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETF-YTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTP 1013          

Query:  394 SVINFVKEMPDVIFGPICDYVIAPIARLMAFWNR--PVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVK-NWPIKVYTELHPNDI---KNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNF-INGEYLFLNIDIFSSQDIIERPWYRK-DRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTD---ENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIH--RRTKFQAELNAMNWIIPWDDLE------------------------------TSEKRRRKFSDGDNFHPYTKKRFSNIMNK--------------NEMENLSLTKDDELKHES-----IENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLD----------------TIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXX----XXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKG-NKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVR---NKDSPPFRPTLMLT------DGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHG 3498
            +V   +++  D I G    Y +AP+AR+  +W    P+IT   L  +    R  E+  +TR+ S +  K     +S LF+ YKW +  ++F      S     C  L   L    RK+++       + E H  +I   +  +   N L       N I ILCA PD VR+IML A  L    +GEY+F+NID+ S+    E+PW R  D  NEENE AK+A+R L TI+LR+ + ++YK F   VK RA  +YN+T+   ++  +N+F+S+F+DAV+LYA+ LN+T+  G    +G  +   MW R+F  +   V+I  +GDRY+D+SL+DL+     F  V+ Y G   + K V    + W  V  K P D P CGYD S CP+ GY +      +MG+F+ I ++ G+FI   RR K + EL AM+W I W++L+                               S  R    SD  +    T ++ S ++++                 +N  LT +   K E+     I        ++  +         R+ NS ++D  N + KSL                 +   +   + +  Q++ KTA+FKG +VA+K +N++ K     +++   L+E+KK+KD+ +DHI RF G C+D P+  +V EYCPKGSLED+L  E+I+LD + KYSL+ D+ +G+ +LHN+    HG LKSSNC+VDSRFVLK+TDFGL  L    + N+     + YYK  LWTAPELL  SN P  GT KGD+YSFA+I  E+++R GVF+L  + +L+  EI ++VR   ++D  P RP +  T      D   D +L L+   W EDP  RP+ ++++  +R LN+  +T N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP  +A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + H+ +IA+MS++ L  +  F+I HRP ++L+LRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+SQ T +IL     F +  RG +++KGKG+Q TYWL G
Sbjct:  110 AVEQLLRKQIDCIIGYAYGYALAPVARMSPYWKNGIPIITPIGLTMSLDDKR--EYQLMTRINSPY--KVVSSAVSTLFNTYKWKRHIFMFHHAKAPSVAVGECFLLMASLQHPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVI-ILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQ--LHW--VGGKPPTDLPICGYDKSKCPQ-GYPLHVYL--LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLRSTSRSSVNSDKRSSSSGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGLTPNSLQKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224          

Query:  424 DVIFGPICDYVIAPIARLMAFWNR--PVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLG----IYLVKGARKIVKN-----WPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNF-INGEYLFLNIDIFSSQDIIERPWYRK-DRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTD---ENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIH--RRTKFQAELNAMNWIIPWDDLE------------------------------TSEKRRRKFSDGDNFHPYTKKRFSNIMNK--------------NEMENLSLTKDDELKHES-----IENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLD--------------TIIGINLDSMHK--VQLFAKTALFKGNLVALKPINVNGXX----XXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKG-NKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVR---NKDSPPFRPTLMLT------DGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHG 3498
            D I G    Y +AP+AR+  FW +  PV TT AL      DR  EF  LTR+   +  K  G L++ +  +++W   ++ FF   +N  +       G     + +   + ++ N     W +K+++E   + ++  +     L+ +    + + ILCA PD VR+IML A  L    +GEY+F+NID+ S+    E+PW R  D  NEENE AK+A+R L TI+LR+ + ++YK F   VK RA  +YN+T+   ++  +N+F+S+F+DAV+LYA+ LN+T+  G    +G  +   MW R+F  +   V+I  +GDRY+D+SL+DL+     F  V+ Y G   + K V    + W  V  K P D P CGYD S CP+ GY +      +MG+F+ I ++ G+FI   RR K + EL AM+W I W++L+                               S  R    SD  +    T ++ S ++++                 +N  LT +   K E+     I        ++  +         R+ NS ++D  N + KSL               +  G +++++ +   Q++ KTA+FKG +VA+K +N++ K     +++   L+E+KK+KD+ +DHI RF G C+D P+  +V EYCPKGSLED+L  E+I+LD + KYSL+ D+ +G+ +LHN+    HG LKSSNC+VDSRFVLK+TDFGL  L    + N+     + YYK  LWTAPELL  SN P  GT KGD+YSFA+I  E+++R GVF+L  + +L+  EI ++VR   ++D  P RP +  T      D   D +L L+   W EDP  RP+ ++++  +R LN+  +T N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP  +A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + H+ +IA+MS++ L  +  F+I HRP ++L+LRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+SQ T +IL     F +  RG +++KGKG+Q TYWL G
Sbjct:  103 DAIMGLPYVYALAPVARISKFWGQGVPVFTTTALVDELG-DR-NEFPLLTRMMGSY--KSLGKLVTRIAERFEW---QHYFF--MFNDEVARGPRNKGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRLQYRA-----LLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQ--LHW--VGGKPPTDLPICGYDKSKCPQ-GYPLHVYL--LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQKKNEKKKAKKRKNHNDYLPESDPLLRSTSRSSVNSDKRSSSSGTTRKISAMIDRKLSIFTRKKSTPPSESQKNGGLTPNSLQKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203          

Query: 1918 SNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXX----XXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKG-NKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVR---NKDSPPFRPTLMLT------DGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHG 3498
            S  S++TI      + +  Q++ KTA+FKG +VA+K +N++ K     +++   L+E+KK+KD+ +DHI RF G C+D P+  +V EYCPKGSLED+L  E+I+LD + KYSL+ D+ +G+ +LHN+    HG LKSSNC+VDSRFVLK+TDFGL  L    + N+     + YYK  LWTAPELL  SN P  GT KGD+YSFA+I  E+++R GVF+L  + +L+  EI ++VR   ++D  P RP +  T      D   D +L L+   W EDP  RP+ ++++  +R LN+  +T N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP  +A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + H+ +IA+MS++ L  +  F+I HRP ++L+LRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIH+SQ T +IL     F +  RG +++KGKG+Q TYWL G
Sbjct:  727 SGGSVETI------AQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262          

Query:  424 DVIFGPICDYVIAPIARLMAFWNR--PVITTGALYYAFSSDRIAEFHTLTRV-GSGHLDKYTGYLI-------SELFSKYKWNKGKYIFF----KDAYNSTIPM-----------YCH----GLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNF-INGEYLFLNIDIFSSQDIIERPWYRK-DRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTD---ENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIH--RRTKFQAELNAMNWIIPWDDLETSEKR 1683
            D I G   +Y +A + ++ A  N   P++TT  +    +S +  E+  LTR+ GS  L   + Y +       S   S    N    IFF    + A N  I             +C+     +  Y  + ++   + W +         D+  +       + +I  ++ + ILCA PD VR+IML A  L    +GEY+F+NID+ S+    E+PW R  D  NEENE AK+A+R L TI+LR+ + ++YK F   VK RA  +YN+T+   ++  +N+F+S+F+DAV+LYA+ LN+T+  G    +G  +   MW R+F  +   V+I  +GDRY+D+SL+DL+     F  V+ Y G   + K V    + W  V  K P D P CGYD S C  PGY +      +MG+F+ I ++ G+FI   RR K + EL AM+W I W++L+  E +
Sbjct:  120 DAILGFADNYGLATVTKVTAGLNGGIPILTTSGMPSLLNSKK--EYPFLTRMQGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYEMNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQ--LHW--VGGKPPTDLPICGYDKSKC--PGYPLHVYL--LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEESQ 564          

Query: 1918 SNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXX----XXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKG-NKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVR---NKDSPPFRPTLMLT------DGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGT-----FIISERGHIDLKGKGL 3474
            S  S++TI      + +  Q++ KTA+FKG +VA+K +N++ K     +++   L+E+KK+KD+ +DHI RF G C+D P+  +V EYCPKGSLED+L  E+I+LD + KYSL+ D+ +G+ +LHN+    HG LKSSNC+VDSRFVLK+TDFGL  L    + N+     + YYK  LWTAPELL  SN P  GT KGD+YSFA+I  E+++R GVF+L  + +L+  EI ++VR   ++D  P RP +  T      D   D +L L+   W EDP  RP+ ++++  +R LN+  +T N++DNLL RMEQYANNLEGLV +RT++YL EK+K E+LL+ +LP  +A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + H+ +IA+MS++ L  +  F+I HRP ++L+LRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGL +  + S         F       F+ +E+  I+ +GK +
Sbjct:  100 SGGSVETI------AQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALE-NEDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGKKM 632          

Query: 2092 DMSNDHICRFIGVCLDHPYIV--YEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHIS-QSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            ++ ND++C+FIG+ LD P ++  + YC +GSL+DV+AK  +++DW FKYSLM+D+   + YLH++  GPHG L SS CLVD R+ +K++ FGL ++K  +            + FL TAPE +  +N P+  T + D+YSFA+IC E++ +   + L  +     +E+  K++     P RP+L   D     +  L++  W+E+P  RP    IK LM+ +N    + N++D++ + +EQYA+NLE  V  R ++  EEK++++ LLY MLPK VA +L   Q+V  E++D VTIFFSD+V FT L++  TP+Q++ LLN LYTTFD+IIE +DVYKVETIGD Y+  SGLP  NGN H++EI+ MS + L+AI  F +PH P +++ +R+G+H+GPV +GVVG+ MPRYCLFGD+VNT+SRMESNG P ++HIS +  K + +  G +    RG + +KGKG   T+WL  +D
Sbjct:  581 NVDNDNLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYEVKEQ--------RDFLHTAPEHIRDTNLPI--TKEMDIYSFAIICSELITKKSAWDLE-NETFDIEELVYKIKKGGRSPPRPSLETEDEHNGSMSLLVRDCWNENPDQRPTSEQIKTLMKSMNHN-RSSNLMDHVFNVLEQYASNLEDEVQARMKELTEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHDVYKVETIGDGYLCVSGLPHRNGNEHAKEISSMSFSLLKAIKTFRVPHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGKPGRVHISTECMKFLTEVIGGYQTEPRGEVIVKGKGAVQTHWLLTDD 1043          

Query:  394 SVINFVKEMPDVIFGPIC---DYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFING-EYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKY-------KEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKII-------DWGTVNNKIPLDTPTCGYDLSGCPKPGYN------IGAISAGVMGAFVAIAIIGGVFIHRRTKFQAE 1626
            SVIN+ +    V+ GP C     V   +A+ + F   P+I  G     F S  + +F   T   +     Y    +  L   YKW +   I++  A +  IP         L+     +V N      T      +  +++    L   +     + I+C + D  R+ ++ + S N ++G EY+++  +   +       W   D    +N++A +A R  + +     + +KY       +E  A   R      N T+ +  V S V    DA++LYA  LN +++ G     G    +      F      V I+ +  R   F + +L+       V+           PV   I         W T    +PL TP CG+  + CPK   +      +G  +A ++   + IA+I  +    R+K Q E
Sbjct:   89 SVINYAEGHAHVVLGPPCVRPAQVAGSVAKYLDF---PLILWGP---PFDSSLLNQFEYPTIASTTSSTLYQATSLIRLLEYYKWTEIALIYYV-ARSDLIPRCTP-----LISDFEGLVNNNDNLTITYRRQMSVITNTSYATAL-RNLKELARVVIVCLESDEARRNLMISISENGMDGDEYVYIMAESRRA-GFASSFWNGTD---GKNDLALRAARKFLVM-----DNQKYNDTTTFVQEVRAAFSRPPFSCPNCTNIDPTV-SQVGPLGDALLLYAYALNRSIATGNPNPTGTEFCEVAKGMEFLGFTGKVIINQNSTRTPLFVVYNLDSTDKEMIVMQITEDLDDSKDPVASSITLVATPAQIWDTWGGTVPLSTPICGFTGTDCPKSFTDQYLAIILGCTAAALV---LIIAVISTIVFLVRSKRQEE 497          

Query:  265 IPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDV--IFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFIN-GEYLFLNIDIFSS-QDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFT-DENELVNSFVSSFHDAVILYALGLNDTLSKGGKIE----DGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPK---PGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINV-NGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDH--PYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPN----MYYKSFLWTAPELLNLS-NPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTS-KEIFEKVR----NKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            +P +++ +  V++M            L   D+ C   + P+         + P+V  +FG  C+YV+API+R    W  PV+TTG     F+  +   + TLTR+    ++   G ++  + + + W +   I+     N    +  + +    +      ++     VY           + I  ML + +  ++ I I+CADP  +R+IML A  LN I+ GEY+F+NI++FS  Q +  +PWY K+  +  NE A+KA+  ++T+T ++P   +Y   S E+K  A  +YN+T  +NE +++FV+SF D V+LYA  LN+++ +   +     +G  +V+ MWNRSF  +   VTI  +GDR + +SL+D+N  TG FE+V++++  + +++   +K I W     + P D P CGYD + CP    PGY I +I   V+G  V +  +   F +R    +AE+N+M+W +  +D+   +   R      +FH   K          +   L+L  +D                                                 ++ IN D     Q+F    +F+ + VA+KP+ V N +  +T  L++E+K++KD+ +DH+ +F G CLD    +++ EYCPKGSL+D+L  EQ +LDWMF+ SLM DI RGM +LH++    HGNLKSSNC+VDSRFVLKITDFGL +L+  + ++  +  N     Y+   LWTAPELL +  N P  GT KGDVY+F +I  EI  R G F L       S +EI E V+    ++   PFRP L        D+  +I++ W EDP  RPDF T+K ++R+ NK  +TGNI+DNLL RME YANNLE LV +RT+ Y EEK+K E LLY +LP+ VA QLI  Q V+AE++D VTI+FSDIVGFTA+SAESTPMQ+++ LN LYT FDSI+EN+DVYKVETIGDAYMV SGLP  NGN H+REIAR+++A L+A+  F I HRP+ +L+LRIG+H+G   +GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIHIS++TKE LD FGTF+ + RG + +KGKG  LTYWL GE
Sbjct:  109 LPVLELAIRHVQRM-GFVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNK-KSESYSTLTRLKGAQVNNL-GNVVRAILNSFNWTRTALIY----QNENAKVKGNSVCFLCLAAIHDTIEEH--SVYQLGFDTSTWTKADITRML-KNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEA--NKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSI---VLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRG--SFHSLVK----------QSSQLTLMSED-------------------------------------------------MVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131          

Query:  265 IPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDV--IFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFIN-GEYLFLNIDIFSS-QDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFT-DENELVNSFVSSFHDAVILYALGLNDTLSKGGKIE----DGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPK---PGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINV-NGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDH--PYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPN----MYYKSFLWTAPELLNLS-NPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTS-KEIFEKVR----NKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            +P +++ +  V++M            L   D+ C   + P+         + P+V  +FG  C+YV+API+R    W  PV+TTG     F+  +   + TLTR+    ++   G ++  + + + W +   I+     N    +  + +    +      ++     VY           + I  ML + +  ++ I I+CADP  +R+IML A  LN I+ GEY+F+NI++FS  Q +  +PWY K+  +  NE A+KA+  ++T+T ++P   +Y   S E+K  A  +YN+T  +NE +++FV+SF D V+LYA  LN+++ +   +     +G  +V+ MWNRSF  +   VTI  +GDR + +SL+D+N  TG FE+V++++  + +++   +K I W     + P D P CGYD + CP    PGY I +I   V+G  V +  +   F +R    +AE+N+M+W +  +D+   +   R      +FH   K          +   L+L  +D                                                 ++ IN D     Q+F    +F+ + VA+KP+ V N +  +T  L++E+K++KD+ +DH+ +F G CLD    +++ EYCPKGSL+D+L  EQ +LDWMF+ SLM DI RGM +LH++    HGNLKSSNC+VDSRFVLKITDFGL +L+  + ++  +  N     Y+   LWTAPELL +  N P  GT KGDVY+F +I  EI  R G F L       S +EI E V+    ++   PFRP L        D+  +I++ W EDP  RPDF T+K ++R+ NK  +TGNI+DNLL RME YANNLE LV +RT+ Y EEK+K E LLY +LP+ VA QLI  Q V+AE++D VTI+FSDIVGFTA+SAESTPMQ+++ LN LYT FDSI+EN+DVYKVETIGDAYMV SGLP  NGN H+REIAR+++A L+A+  F I HRP+ +L+LRIG+H+G   +GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIHIS++TKE LD FGTF+ + RG + +KGKG  LTYWL GE
Sbjct:  109 LPVLELAIRHVQRM-GFVGGSHFDIQLISRDTFCSSKYGPI--GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNK-KSESYSTLTRLKGAQVNNL-GNVVRAILNSFNWTRTALIY----QNENAKVKGNSVCFLCLAAIHDTIEEH--SVYQLGFDTSTWTKADITRML-KNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEA--NKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSI---VLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRG--SFHSLVK----------QSSQLTLMSED-------------------------------------------------MVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131          

Query: 1978 LFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGP---HGNLKSSNCLVDSRFVLKITDFGLPSLKG----NKTNMMHEEPNMYYKSFLWTAPELLNLS-NPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDS--PPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            +F    L+KG L A+K +     ++IT E+  E+K ++D  +D+IC FIG C D P   I+ EYC +GSL+D+L  E +KLD MF  S++ DI RG+IYLH++  P   HG L +SNCLVDSR+V+K+TDFGL + K     + T+M H          L+ APELL    +  V GT +GD YSF ++  E+  R G F  T    LT  +  +KV        P+RP+L   +   D V + +++ W E P  RPDF TI+  +R L KG    NI DN+++ ME+YANNLE LV  RT+Q  EEK+K + LL+ MLP+ VA QL K   V  E Y+ V+I+FSDIVGFTA+SAE TP+Q+++ LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LH+ EIA MS+  L A+S F I HRP  +L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+PLKIH S   +++LD  G +  +ERG I +KGKG Q TYWL GED
Sbjct:  575 IFTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCL--KLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGET---GLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED 1086          

Query:  469 ARLMAFWNRPVITTGALYYAFSSD--RIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGAR-KIVKNWPIKVYTELHPNDIKNDSTIDN---MLIEQIGNKNAINILCADPDIVRKIMLRAASLNFIN-GEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEV-KRRAKMEYNFTDE------NELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFES-LGTTVTISPDGDRYADFSLM-------DLNQQTGMFEVVSNYIGRKRKYKPVNDKI--------IDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESI 1812
             R+ A +N P+I+    YY    D    A+F T  R      D      +  L   + W +  +++  DA     P+    L      G   + ++ W          N I +   +DN    L+EQ      I ++         +M+       ++ G+Y  + IDI          + R     +   +A +AF++ + I         +  F+ EV K   +  +NF +        + +++  +  +DAV LYA  L + L  GG+  +G  +V  +    + S +G  V I  +GD   +++++         NQ       V  +I R      ++  +        IDW  V    P   P CG+    C       G ISA + G  + +  +  + ++R  +++ EL+++ W I + +++  E  R + S         + R ++ + +    +LS   D + ++ +I
Sbjct:  128 GRMAAAFNLPMIS----YYCTHRDPSNKADFPTFARTRPP--DTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTW----------NTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIV--PTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN---YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQ-------KQTRSTHPLIRTSQVSLSSNPDADFRYTTI 575          

Query: 1978 LFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGP---HGNLKSSNCLVDSRFVLKITDFGLPSLKG----NKTNMMHEEPNMYYKSFLWTAPELLNLS-NPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDS--PPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            +F    L+KG L A+K +     ++IT E+  E+K ++D  +D+IC FIG C D P   I+ EYC +GSL+D+L  E +KLD MF  S++ DI RG+IYLH++  P   HG L +SNCLVDSR+V+K+TDFGL + K     + T+M H          L+ APELL    +  V GT +GD YSF ++  E+  R G F  T    LT  +  +KV        P+RP+L   +   D V + +++ W E P  RPDF TI+  +R L KG    NI DN+++ ME+YANNLE LV  RT+Q  EEK+K + LL+ MLP+ VA QL K   V  E Y+ V+I+FSDIVGFTA+SAE TP+Q+++ LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LH+ EIA MS+  L A+S F I HRP  +L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+PLKIH S   +++LD  G +  +ERG I +KGKG Q TYWL GED
Sbjct:  577 IFTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCL--KLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGET---GLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED 1088          

Query:  469 ARLMAFWNRPVITTGALYYAFSSD--RIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGAR-KIVKNWPIKVYTELHPNDIKNDSTIDN---MLIEQIGNKNAINILCADPDIVRKIMLRAASLNFIN-GEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEV-KRRAKMEYNFTDE------NELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFES-LGTTVTISPDGDRYADFSLM-------DLNQQTGMFEVVSNYIGRKRKYKPVNDKI----------IDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESI 1812
             R+ A +N P+I+    YY    D    A+F T  R      D      +  L   + W +  +++  DA     P+    L      G   + ++ W          N I +   +DN    L+EQ      I ++         +M+       ++ G+Y  + IDI          + R     +   +A +AF++ + I         +  F+ EV K   +  +NF +        + +++  +  +DAV LYA  L + L  GG+  +G  +V  +    + S +G  V I  +GD   +++++         NQ       V  +I R      ++  +          IDW  V    P   P CG+    C       G ISA + G  + +  +  + ++R  +++ EL+++ W I + +++  E  R + S         + R ++ + +    +LS   D + ++ +I
Sbjct:  128 GRMAAAFNLPMIS----YYCTHRDPSNKADFPTFARTRPP--DTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTW----------NTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIV--PTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN---YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQ-------KQTRSTHPLIRTSQVSLSSNPDADFRYTTI 577          

Query: 1978 LFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGP---HGNLKSSNCLVDSRFVLKITDFGLPSLKG----NKTNMMHEEPNMYYKSFLWTAPELLNLS-NPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDS--PPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            +F    L+KG L A+K +     ++IT E+  E+K ++D  +D+IC FIG C D P   I+ EYC +GSL+D+L  E +KLD MF  S++ DI RG+IYLH++  P   HG L +SNCLVDSR+V+K+TDFGL + K     + T+M H          L+ APELL    +  V GT +GD YSF ++  E+  R G F  T    LT  +  +KV        P+RP+L   +   D V + +++ W E P  RPDF TI+  +R L KG    NI DN+++ ME+YANNLE LV  RT+Q  EEK+K + LL+ MLP+ VA QL K   V  E Y+ V+I+FSDIVGFTA+SAE TP+Q+++ LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LH+ EIA MS+  L A+S F I HRP  +L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+PLKIH S   +++LD  G +  +ERG I +KGKG Q TYWL GED
Sbjct:  588 IFTPIGLYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCL--KLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGET---GLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRP-NIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGED 1099          

Query:  469 ARLMAFWNRPVITTGALYYAFSSD--RIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGAR-KIVKNWPIKVYTELHPNDIKNDSTIDN---MLIEQIGNKNAINILCADPDIVRKIMLRAASLNFIN-GEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEV-KRRAKMEYNFTDE------NELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFES-LGTTVTISPDGDRYADFSLM-------DLNQQTGMFEVVSNYIGRKRKYKPVNDKI--------IDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFH 1716
             R+ A +N P+I+    YY    D    A+F T  R      D      +  L   + W +  +++  DA     P+    L      G   + ++ W          N I +   +DN    L+EQ      I ++         +M+       ++ G+Y  + IDI          + R     +   +A +AF++ + I         +  F+ EV K   +  +NF +        + +++  +  +DAV LYA  L + L  GG+  +G  +V  +    + S +G  V I  +GD   +++++         NQ       V  +I R      ++  +        IDW  V    P   P CG+    C       G ISA + G  + +  +  + ++R  +++ EL+++ W I + +++  E  R + S     H
Sbjct:  128 GRMAAAFNLPMIS----YYCTHRDPSNKADFPTFARTRPP--DTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTW----------NTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIV--PTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN---YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENEREQQSQKQTRH 550          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            Q+FAKT  FKGN+VA+K IN   ++E+T ++L E+K ++D+ N+H+ RFIG C+D P   IV EYCP+GSL+++L  + I LDWMFKYSL+ DI +GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S++   T    E+ + YY   LW APEL  +   P  GT KGDVYSF +I QE+  R GVF L  D  L+ KEI ++V   + P  RP+L      ++++ +L+Q+ W E+P+ RP+F+ I +L+RK N+   + NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARMS+A L+A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S +T+ +L  F  F +  RG +++KGKG   TYWL GE
Sbjct:  308 QVFAKTGYFKGNIVAIKYIN-RRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR---TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL-LSPKEIVDRVALGEWPYLRPSLN-PQAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812          

Query:  859 LCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDG 1704
            +C  PD+ R++++          EY+F  IDIF  S +    +PW R D    ++  AK+AF+++  +T  +P+ ++YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++LS   +   GE V K MWNR++  +   V I  +GDR  DF+L D+    TG F++V+ Y G +++   +    I W     K+P+D PTCG+  +   C      +  + + V+   + I     VFI+R+ K + EL A  W I WDD++ S   +   S G
Sbjct:    4 VCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGD---SDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWP--GGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTG 285          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNI 3513
            K QLFAKT  FKGNLVA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMF+YSL+ DI +GM YLHN++ G HGNLKSSNC+VDSRFVLKITD+GL S + +  N   E+ +  Y   LWTAPELL     P  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT   +  C +++  L++  W EDP  RPDF+ IK+ + K NK       L   LSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIA MS+A L+ +  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMES G  L+IH+S +TKE+LD FG F +  RG +++KGKG   TYWL GE +++
Sbjct:  540 KYQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---EDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVE-GMDLSPKEIIQKVRNGQKPYFRPTTDNSRHC-EELTILMEGCWSEDPAERPDFSHIKVFIAKFNKQHQYSQYL---LSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGEKTDV 1048          

Query:  220 LLLPKNFSTFPWA--LTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD--CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKI-VKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLE 1668
            ++LP+N   + WA    +P+I+M  EK++K   +     N+      DS   C +    +  +V   +   PD   GP C Y +A + R  + W  P+IT G   Y F  D+  EF T+ R G     K  G  ++ L  ++ W+    + F D      P Y    GIY V     I V  +P   Y +    + K+       +I  I +   I  +C       +IM           +Y    +D+F  S    +  PW   D    +     K F+++  +T ++P+  +Y  F  E+ +RA  ++N   E  +++     FHD  +LYA  L++ L+ G    DG  +   M NR    +   V+I     R+ DFSL  + N ++G + +V +Y G  ++      + I W       PLD P CG+  S C +    +  I A   G  + I  I    I+R+ K + EL  M W I W++L+
Sbjct:   40 VMLPENLK-YSWASPRVLPAIRMAQEKIQKSGLLRGHTINLLNFSTEDSSGSCSENEAQII-AVDTKLYHKPDAFIGPGCTYSVASVGRFASHWKLPLITAGGPAYGF--DKWEEFKTIVRTGP--TTKKLGDFVNYLHGQFNWSSRALMIFHDLKQDDRPHYFLSEGIYTVLREENITVLAFP---YEDEQTYNYKD-------MITFIKDNGRIVYICGPLPTFFQIMKLFEDEVKSPEDYAIFYLDVFAESLSGDVPMPWQGSDIQWND---PIKLFQSVFVVTYQEPDSPEYTAFRKELHKRAIQDFNVQLEPSMMDFIAGCFHDGFVLYAKALSEALADGVSQNDGINITARMQNRRLWGVTGLVSIDQKNARFTDFSLWAMTNLKSGQYAIVGHYNGTSKEILWSPTEKIQWP--KGCPPLDYPPCGF--SPCKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQ 507          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q++AKT  +KGN+ A+K +N   +IE+T ++L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D++  E I LDWMF+YSL+ DI +GM +LHN+    HGNLKSSNC+VDSRFVLKITD+GL S   + +N+  ++ + +Y   LWTAPELL   NPP  GT KGDVYSF +I QE+    GVF L   P L+ KEI E+V     P  RP L+     ++++ +L+ + W ED   RPDF+ IK+L+RK N  G   NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPM+++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S++T+ +L  F  F +  RG +++KGKG   TYWL GE S+
Sbjct:  557 QIYAKTGYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKD-SNL--DDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLE-GPCLSPKEIIERVVEGRWPYLRP-LLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEISS 1064          

Query:  220 LLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNM---------LIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRR 1686
            ++LP + + +PWA     P++   LEKV    N+        +    ++    C  +  PL    + F    P    GP CDY  +P+AR    W  P+IT+GA    F+      + ++T +G  H  K  G  +  +   + W+K   + F D  N   P Y      + V+G            YT++  ++I  D  + N          L+  I +K  +  +C   +  RK+M+      F   EY F  ID+F  S Q    RPW R D    ++  AK+AF+++  +T R+P+  +YK+F +++K  A   +NF  E+ L+N    SFHD V+LY+  LNDT+ + G    G++V K MWNR++  +   V +  +GDR  DF+L D+ + +TG +++VS Y G +++        + W  +  + P D P CG+  D   C      +  + + V+     I +   VFI+R+ K + EL A  W + W+D++ S   +
Sbjct:   51 VILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYN-PWAFIGPGCDYSSSPVARFTTHWEVPMITSGARALGFNL-----YSSITNIGPTH--KKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCY------FAVEGP-----------YTQMREDNITADDLVFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGD---ADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW--LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEK 528          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q++AKT  +KGN+ A+K +N   +IE+T ++L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D++  E I LDWMF+YSL+ DI +GM +LHN+    HGNLKSSNC+VDSRFVLKITD+GL S   + +N+  ++ + +Y   LWTAPELL   NPP  GT KGDVYSF +I QE+    GVF L   P L+ KEI E+V     P  RP L+     ++++ +L+ + W ED   RPDF+ IK+L+RK N  G   NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPM+++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S++T+ +L  F  F +  RG +++KGKG   TYWL GE S+
Sbjct:  557 QIYAKTGYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKD-SNL--DDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLE-GPCLSPKEIIERVVEGRWPYLRP-LLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEISS 1064          

Query:  220 LLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNM---------LIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRR 1686
            ++LP + + +PWA     P++   LEKV    N+        +    ++    C  +  PL    + F    P    GP CDY  +P+AR    W  P+IT+GA    F+      + ++T +G  H  K  G  +  +   + W+K   + F D  N   P Y      + V+G            YT++  ++I  D  + N          L+  I +K  +  +C   +  RK+M+      F   EY F  ID+F  S Q    RPW R D    ++  AK+AF+++  +T R+P+  +YK+F +++K  A   +NF  E+ L+N    SFHD V+LY+  LNDT+ + G    G++V K MWNR++  +   V +  +GDR  DF+L D+ + +TG +++VS Y G +++        + W  +  + P D P CG+  D   C      +  + + V+     I +   VFI+R+ K + EL A  W + W+D++ S   +
Sbjct:   51 VILPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYN-PWAFIGPGCDYSSSPVARFTTHWEVPMITSGARALGFNL-----YSSITNIGPTH--KKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCY------FAVEGP-----------YTQMREDNITADDLVFNEDEEPLRYDELLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGD---ADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW--LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSNTEK 528          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            Q+FAKT  FKGN+VA+K IN   ++E+T ++L E+K ++D+ N+H+ RFIG C+D P   IV EYCP+GSL+++L  + I LDWMFKYSL+ DI +GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S++   T    E+ + YY   LW APEL  +   P  GT KGDVYSF +I QE+  R GVF L  D  L+ KEI ++V   + P  RP+L      ++++ +L+Q+ W E+P+ RP+F+ I +L+RK N+     +I+      + QYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARMS+A L+A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S +T+ +L  F  F +  RG +++KGKG   TYWL GE
Sbjct:  561 QVFAKTGYFKGNIVAIKYIN-RRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIR---TESDTEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDL-LSPKEIVDRVALGEWPYLRPSLN-PQAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNRSVPHYSIV------LSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1060          

Query:  220 LLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLY---PIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDI--------KNDSTID-NMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP++ +++PWA     P++   + +V    N+ P  +   +       D  C ++  PL    + F +  P    GP CDY  +P+    A W  P+IT GA   AF    I  + ++T  G  H  K  G     L+  + WN+   + F D        Y      + ++G           +YTE+H  +I        +N   ++ + L+ +I     +  +C  PD+ R++++          EY+F  IDIF  S +    +PW R D    ++  AK+AF+++  +T  +P+ ++YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++LS   +   GE V K MWNR++  +   V I  +GDR  DF+L D+    TG F++V+ Y G +++   +    I W     K+P+D PTCG+  +   C      +  + + V+   + I     VFI+R+ K + EL A  W I WDD++ S   +   S G   
Sbjct:   52 VILPQHNTSYPWAWPRVGPALDRAIARVNANPNLLPRHRVRHVFANSEDRDGICSESMAPLMAVDLKF-EHNPWAFIGPGCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQMEI--YTSITNTGPTH--KKLGEYALHLYRHFGWNQHSLLMFSDTKMGERACY------FALEG-----------LYTEMHEENITTMDLVFEENKGPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGD---SDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWP--GGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMSHLEKALRSTGSKL 541          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLK-LIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGK------GLQLTYWLHG 3498
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RF+G C+D P   IV EYCP+GSL+D+L  E I LDWMF+ SL+ DI +GM +LH +  G HGNLKSSNC+VDSRFVLKITD+GL S +   ++   ++    Y   LWTAPELL ++ PP  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT+ ++  C  + L  L+ + W E+P  RPDF  IK  + K NK G T +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IHIS +TKE+LD F  F +  RG I++K K      GL L    HG
Sbjct:   52 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVKIPLVATGLGLHTRCHG 563          

Query: 1882 RYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLK-LIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHG 3498
            R+   +   S   +K+  +  G  + +  K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RF+G C+D P   IV EYCP+GSL+D+L  E I LDWMF+ SL+ DI +GM +LH +  G HGNLKSSNC+VDSRFVLKITD+GL S +   ++   ++    Y   LWTAPELL ++ PP  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT+ ++  C  + L  L+ + W E+P  RPDF  IK  + K NK G T +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IHIS +TKE+LD F  F +  RG I++K K + L    HG
Sbjct:   76 RWEELQFGNSERYHKTRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK-IPLVSLSHG 609          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLK-LIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGK 3468
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RF+G C+D P   IV EYCP+GSL+D+L  E I LDWMF+ SL+ DI +GM +LH +  G HGNLKSSNC+VDSRFVLKITD+GL S +   ++   ++    Y   LWTAPELL ++ PP  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT+ ++  C  + L  L+ + W E+P  RPDF  IK  + K NK G T +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IHIS +TKE+LD F  F +  RG I++K K
Sbjct:  137 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLK-LIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGK 3468
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RF+G C+D P   IV EYCP+GSL+D+L  E I LDWMF+ SL+ DI +GM +LH +  G HGNLKSSNC+VDSRFVLKITD+GL S +   ++   ++    Y   LWTAPELL ++ PP  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT+ ++  C  + L  L+ + W E+P  RPDF  IK  + K NK G T +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IHIS +TKE+LD F  F +  RG I++K K
Sbjct:  182 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLK-LIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGK 3468
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RF+G C+D P   IV EYCP+GSL+D+L  E I LDWMF+ SL+ DI +GM +LH +  G HGNLKSSNC+VDSRFVLKITD+GL S +   ++   ++    Y   LWTAPELL ++ PP  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT+ ++  C  + L  L+ + W E+P  RPDF  IK  + K NK G T +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L+A+  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IHIS +TKE+LD F  F +  RG I++K K
Sbjct:  210 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSCEADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQKVRNGQRPYFRPTVDIS--CHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEGST-SILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKTA +KGNLVA+K +N   +IE+T ++L E+K ++D+ N+H+ RF+G C D P   I+ EYCP+GSL+D+L  E I LDWMF+YSL  DI +GM++LHN   G HGNLKSSNC+VD RFVLKITD+GL S +  +     E+ +  +   LWTAPELL +++PP  G+  GDVYSF +I QEI  R+GVF +    +L+ KEI E+V   + PPFRP++ L     +++ +L+Q+ W EDP  RP F  I+L +RK NK  ++ NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH+RE+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IH+S  TK +L+ F  F +  RG +++KGKG   TYWL GE
Sbjct:  537 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIERVTRGEQPPFRPSMDLQSHL-EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050          

Query:  220 LLLPKNFSTFPW--ALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYL-VKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF------SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP   +++PW  A   P++++ L +V+   ++ P      +L   ++    C  T  PL    + + +  P V  GP C Y  AP+ R  A W  P++T GA   A       E+   TR G  H+    G  ++ L  +  W     + + D      P +    G+Y+ V+    I  N         H   ++ D      L+  +  K  +  +C+ PD  R +ML A        +Y+F ++D+F      +   +  +PW R D    ++  A++AF+    IT ++P+  +Y EF  ++K  A  ++NFT E+ L N   +SFHD ++LY   + +TL++GG + DGE + + MWNRSF+ +   + I  +GDR  DFSL D++ +TG F VV N+ G  ++   V++  + W       P D P CG+D     C +  ++   + A V    +   +I   FI+R+ + + EL +  W + W+DL+ S   R   S G   
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKW-EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGA--PALGIGVKDEYALTTRTGPSHVK--LGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVN---------HQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDD---GQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPL--GYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRL 527          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  + I LDWMF+YSL+ D+ +GM +LHN+    HG+LKSSNC+VDSRFVLKITD+GL S +        ++ +  Y   LWTAPELL+ +  P  G  K DVYSFA+I QEI  R+G F L    +L+ KEI +KVRN   P FRP++  T    ++++ L+++ W +DPT RPDF  IK  +R+ NK G T +ILDNLL RMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ EIARM++A L A+S F I HRP  +L LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TK+ LD  G F +  RG +++KGKG   TYWL GE 
Sbjct:   99 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEP---DDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 606          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  + I LDWMF+YSL+ D+ +GM +LHN+    HG+LKSSNC+VDSRFVLKITD+GL S +   +    ++ +  Y   LWTAPELL+ +  P  G  K DVYSFA+I QEI  R+G F L    +L+ KEI +KVRN   P FRP++  T    ++++ L+++ W +DPT RPDF  IK  +R+ NK G T +ILDNLL RMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ EIARM++A L A+S F I HRP  +L LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TK+ LD  G F +  RG +++KGKG   TYWL GE
Sbjct:  533 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFR---STAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039          

Query:  187 VRP--NRDYPLAMLLLPKNFS-TFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFS 1740
            VRP   R+  LA++L   N S  + W    P++ + +E + +   ++    + +    +D  C +   PL    +    + PD++ GP C Y  A +AR  + W  P++T GA+   F++ +   + TL R G        G  +  L   + W     + + DA     P Y      + ++G  + ++   + V  +++  +        +     I     I  +C   +++ +I+L+A   N  NG+Y+F  +D+F             RPW + +R  E+ +  ++AF+T++ IT R+P   +Y+EF   +  RA+ ++       L+N     F+D ++LYA  LN+T+ +GG  EDG  +V+ M  R +  +   V +  + DR  DF L  +    +G F+  ++Y G +++      + I W  V    PLD P C +DL    C K   +  AI A   G    +  +    I R+   + EL +M W I W++L+        F + D +H     R +
Sbjct:   17 VRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSE----LDGACSEYLAPLRAVDLKLYHD-PDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAA-KNEHYRTLVRTGPSA--PKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHY------FTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHF----IRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIW-WTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ--------FGNSDRYHKGAGSRLT 516          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSG 3273
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  + I LDWMF+YSL+ D+ +GM +LHN+    HG+LKSSNC+VDSRFVLKITD+GL S +        ++ +  Y   LWTAPELL+ +  P  G  K DVYSFA+I QEI  R+G F L    +L+ KEI +KVRN   P FRP++  T    ++++ L+++ W +DPT RPDF  IK  +R+ NK G T +ILDNLL RMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ EIARM++A L A+S F I HRP  +L LRIG+H+G
Sbjct:  533 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEP---DDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963          

Query:  187 VRP--NRDYPLAMLLLPKNFS-TFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFS 1740
            VRP   R+  LA++L   N S  + W    P++ + +E + +   ++    + +    +D  C +   PL    +    + PD++ GP C Y  A +AR  + W  P++T GA+   F++ +   + TL R G        G  +  L   + W     + + DA     P Y      + ++G  + ++   + V  +++  +        +     I     I  +C   +++ +I+L+A   N  NG+Y+F  +D+F             RPW + +R  E+ +  ++AF+T++ IT R+P   +Y+EF   +  RA+ ++       L+N     F+D ++LYA  LN+T+ +GG  EDG  +V+ M  R +  +   V +  + DR  DF L  +    +G F+  ++Y G +++      + I W  V    PLD P C +DL    C K   +  AI A   G    +  +    I R+   + EL +M W I W++L+        F + D +H     R +
Sbjct:   17 VRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSE----LDGACSEYLAPLRAVDLKLYHD-PDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAA-KNEHYRTLVRTGPS--APKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHY------FTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHF----IRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIW-WTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ--------FGNSDRYHKGAGSRLT 516          

Query: 1978 LFAKTALFKGNLVALKPINVNGXX-XXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYR--NGVFSLTPDPNLTSKEIFEKVRNKDSP-PFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD*IY*NFTNTDSRIQE 3579
             FA   L++GN VAL  I    +       +  E+  + ++ +++I  F GVC + P   IV +YC KGSL+DV+     ++DW+FK S   DI  G+++LH +    HGNLK SNCLVDS   LK++ FGL   K   T   + +    +    WTAPELL L   P +GT +GDVYSFA++ ++++++  +G F    D     +EI  ++++  +P P RP+L L D     ++ L+++ WDE P  RP F +IK  +R+ +  G   +ILD+++ ++E YAN+LE +V +RT + + EK+K E LL +MLP FV  QLI  ++V  E ++ VTIFFSDIVGFT L + S+P+Q+++LLN LY+ FD  I+++DVYKVETIGDAYMV SGLP  NG  H+ EIA M++  L   + F I H P+++L+LRIG+H+GPV +GVVG+ MPRYCLFGDTVN +SRMES+ LPL+IH+SQST   L   G + + +RG I +KGKG Q T+WL G+D   V PLP       FT  ++++ E
Sbjct:  570 FFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFE---DLEAAPEEIISRIKDPRAPVPLRPSL-LEDKGDGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHV-SILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPV-PLP------EFTEEEAKVSE 1098          

Query:  790 IKNDSTIDNMLIEQIGN----KNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTT--VTISPDGDRYADFSLMDLNQQTG---MFEVVSNYIGRKRKYKPV-NDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMG--------AFVAIAIIGGVFIHR-RTKFQAELNAMNWIIPWDDL 1665
            ++ +S+  ++L E + N       I ++C+  D  R+I+  A  L    GE++F+ +     +D   +    KD+     ++ +  F    +        + +++  ++  RR   + + T E++ V+ + +  HDA++LYA  + +         DG  ++  +        G T  V +   G R+ D+S+  L Q++G   +F    +Y   ++  +P  ND    W   +  +P   P CG+    C      +  ++  V             + A I G+ + R R K Q+      W I +D +
Sbjct:  222 MRYNSSSSDLLQEGLRNMSYVARVIILICSSED-ARRILQAAVDLGLDTGEFVFILLQQL--EDSFWKEVLTKDKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQ-VSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYAL-QESGNRSLFLPFLHYDSFQKVIRPWRNDSNTSWP--HGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSI 525          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKTA +KGNLVA+K +N   +IE+T ++L E+K ++D+ N+H+ RF+G C D P   I+ EYCP+GSL+D+L  E I LDWMF+YSL  DI +GM++LHN   G HGNLKSSNC+VD RFVLKITD+GL S +  +     E+ +  +   LWTAPELL +++PP  G+  GDVYSF +I QEI  R+GVF +    +L+ KEI E+V   + PPFRP++ L     +++ +L+Q+ W EDP  RP F  I+L +RK NK  ++ NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH+RE+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  L+IH+S  TK +L+ F  F +  RG +++KGKG   TYWL GE
Sbjct:  537 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIERVTRGEQPPFRPSMDLQSHL-EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050          

Query:  220 LLLPKNFSTFPW--ALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYL-VKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF------SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP   +++PW  A   P++++ L +V+   ++ P      +L   ++    C  T  PL    + + +  P V  GP C Y  AP+ R  A W  P++T GA   A       E+   TR G  H+    G  ++ L  +  W     + + D      P +    G+Y+ V+    I  N         H   ++ D      L+  +  K  +  +C+ PD  R +ML A        +Y+F ++D+F      +   +  +PW R D    ++  A++AF+    IT ++P+  +Y EF  ++K  A  ++NFT E+ L N   +SFHD ++LY   + +TL++GG + DGE + + MWNRSF+ +   + I  +GDR  DFSL D++ +TG F VV N+ G  ++   V++  + W       P D P CG+D     C +  ++   + A V    +   +I   FI+R+ + + EL +  W + W+DL+ S   R   S G   
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKW-EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGA--PALGIGVKDEYALTTRTGPSHVK--LGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVN---------HQEFVEGDPDHYTKLLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPWERDD---GQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPL--GYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRL 527          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKTA +KGNLVA+K +N   +IE+T ++L E+K ++D+ N+H+ RF+G C D P   I+ EYCP+GSL+D+L  E I LDWMF+YSL  DI +GM++LHN     HGNLKSSNC+VD RFVLKITD+GL S +    ++  E+ +  Y   LWTAPELL +++PPV G+  GDVYSF +I QEI  R+GVF +    +L+ KEI E+V   + PPFRP+L L     +++  L+Q+ W EDP  RP F  I+L +RK N+  ++ NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH+ E+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S  TK +L+ FG F +  RG +++KGKG   TYWL GE
Sbjct:  541 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR----DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVE-GLDLSPKEIIERVTRGEQPPFRPSLALQSHL-EELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054          

Query:  220 LLLPKNFSTFPW--ALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISA----GVMGAFVAIAI-IGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP   +++PW  A   P++++ L +V+   ++ P      +L   ++    C  T  PL    + + +  P V  GP C Y  AP+ R  A W  P++T GA    F      E+   TR G  +     G  ++ L  +  W +   + +  AY      +C     +LV+G    V++  + +  + H    ++D +    L+  +  K  +  +C+ PD  R +ML A        +Y+F ++DIF             RPW R D    ++  A++AF+    IT + P+  +Y EF  ++K  A  ++NFT E+ LVN+  +SFHD ++LY   + +TL+ GG + DGE + + MWNRSF+ +   + I   GDR  DFSL D++ + G F VV NY G  ++   V+ + ++W       P D P CG+D      P  N   +S      ++G+   + I I   FI+R+ + + EL +  W + W+D+E S   R   S G   
Sbjct:   39 VVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKW-EHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVK--DEYALTTRAGPSYAK--LGDFVAALHRRLGWERQALMLY--AYRPGDEEHC----FFLVEGLFMRVRD-RLNITVD-HLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGD---GQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPL--GYPPPDIPKCGFDNE---DPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRL 531          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKTA +KGNLVA+K +N   +IE+T ++L E+K ++D+ N+H+ RF+G C D P   I+ EYCP+GSL+D+L  E I LDWMF+YSL  DI +GM++LHN     HGNLKSSNC+VD RFVLKITD+GL S +  +     E+ +  +   LWTAPELL +++PP  G+  GDVYSF +I QEI  R+GVF +    +L+ KEI E+V   + PPFRP++ L     +++ +L+Q+ W EDP  RP F  I+L +RK NK  ++ NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH+RE+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S  TK +L+ F  F +  RG +++KGKG   TYWL GE
Sbjct:  537 GSLLTTEGQFQVFAKTAYYKGNLVAVKRVN-RKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEP----EQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIERVTRGEQPPFRPSMDLQSHL-EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050          

Query:  220 LLLPKNFSTFPW--ALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYL-VKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF-----SSQDII-ERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNF 1713
            ++LP   +++PW  A   P++++ L +V+   ++ P      +L   ++    C  T  PL    + + +  P V  GP C Y  AP+ R  A W  P++T GA   A       E+   TR G  H+    G  ++ L  +  W     + + D      P +    G+Y+ V+    I  N         H   ++ D      L+  +  K  +  +C+ PD  R +ML A +      +Y+F ++D+F     S+Q ++ ++PW R D    ++  A++AF+    IT ++P+  +Y EF  ++K  A  ++NFT E+ L N   +SFHD ++LY   + +TL++GG + DGE + + MWNRSF+ +   + I  +GDR  DFSL D++ +TG F VV NY G  ++   V++  + W       P D P CG+D     C +  ++   + A V    +   +I   FI+R+ + + EL +  W + W+DL+ S   R   S G   
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKW-EHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGA--PALGIGVKDEYALTTRTGPSHVK--LGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVN---------HQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGD---GQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPL--GYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRL 527          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNI 3513
            K QLFAKT  FKGNLVA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMF+YSL+ DI +GM +LHN++ G HGNLKSSNC+VDSRFVLKITD+GL S + +  N   E+ +  Y   LWTAPELL     P  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT   T   ++++  L++  W EDP  RPDF+ IK+ + KLNK G T +IL+NLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV S     NG LH+REIA MS+A L+ +  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TKE+LD FG F +  RG +++KGKG   TYWL GE +++
Sbjct:  537 KYQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---EDSHALYAKKLWTAPELLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVD-GMDLSPKEIVQKVRNGQKPYFRPTTD-TSCHSEELSILMEGCWAEDPADRPDFSYIKIFVMKLNKEGST-SILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSDSQSRNGKLHAREIAGMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSATKEVLDEFGYFDLQLRGDVEMKGKGKMRTYWLLGEKTDV 1047          

Query:  214 AMLLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVG--SGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ--DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSG--CPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLE 1668
             +++LP N   + +A     P+I+M  + ++K   +        + +  +S    C ++   +  +V   + E PD  FGP C Y +A + R +  W  P+IT  A  + F S    E+ T+ R G  +  L ++  YL     S + W    ++ F D      P Y    G++LV     I          E  P D + +S    M I  + +   I  +C   D   + M    +      +Y    +D+F+    D   +PW   D  N  + I  K F+++  IT ++P+  +YK F  E+  RAK E++   E  L +     F+D  +LYA  LN+TL++GG   DG  + + M NR F  +   V+   + DR  DF+L  + N +TG + +V+ Y G  ++      + I W       PLD P C + +    C +    +  I A   G  + I  I    I+R+ K + EL  M W I W++L+
Sbjct:   29 VVVMLPDNHLKYSFAFPRVFPAIRMAHDDIQKKGKLLRGYTINLLNHSTESQGAGCSESQAQIM-AVDTKLYEKPDAFFGPGCVYSVASVGRFVNHWKLPLITAWAPAFGFDSKE--EYRTIVRTGLSTTKLGEFAHYL----HSHFNWTTRAFMLFHDLKVDDRPYYFISEGVFLVLRRENIT--------VEAVPYDDQKNSDYREM-ISSLKSNGRIVYICGPLDTFLEFMRIFQNEGLPPEDYAIFYLDMFAKSILDKDYKPWESSD-INWTDPI--KLFKSVFVITAKEPDNPEYKAFQRELHARAKQEFSVQLEPSLEDIIAGCFYDGFMLYAQALNETLAEGGSQNDGINITQKMQNRRFWGVTGLVSTDKNNDRDIDFNLWAMTNHKTGQYGIVAYYNGTNKEIVWSETEKIQWP--KGSPPLDNPPCVFSMDEPFCNEDQLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQ 504          

Query: 1969 KVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            K Q+FA T  FKGN+VA+K +N   +IE+T ++L E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  + I LDWMF+YSL+ D+ +GM +LHN+    HG+LKSSNC+VDSRFVLKITD+GL S +        ++ +  Y   LWTAPELL+ +  P  G  K DVYSFA+I QEI  R+G F L    +L+ KEI +KVRN   P FRP++  T    ++++ L+++ W +DPT RPDF  IK  +R+ NK G T +ILDNLL RMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ EIARM++A L A+S F I HRP  +L LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TK+ LD  G F +  RG +++KGKG   TYWL GE
Sbjct:  533 KYQIFANTGHFKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEP---DDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQKVRNGQRPYFRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039          

Query:  187 VRP--NRDYPLAMLLLPKNFS-TFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIY-LVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ------DIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLS--GCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFS 1740
            VRP   R+  LA++L   N S  + W    P++ + +E + +   ++    + +    +D  C +   PL    +    + PD++ GP C Y  A +AR  + W+ P++T GA+   F++ +   + TL R G        G  +  L   + W     + + DA     P Y    G++  ++G+   V++   +VYT   P   +  +         I     I  +C   +++ +I+L+A   N  NG+Y+F  +D+F             RPW + +R  E+ +  ++AF+T++ IT R+P   +Y+EF   +  RA+ ++       L+N     F+D ++LYA  LN+T+ +GG  EDG  +V+ M  R +  +   V +  + DR  DF L  +   ++G F+  ++Y G +++      + I W  V    PLD P C +DL    C K   +  AI A   G    +  +    I R+   + EL +M W I W++L+        F + D +H     R +
Sbjct:   17 VRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSE----LDGACSEYLAPLRAVDLKLYHD-PDLLLGPGCVYPAASVARFASHWHLPLLTAGAVASGFAA-KNEHYRTLVRTGPS--APKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH---QVYTR-EPGGPEQATHF-------IRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW-QDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIW-WTGRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQ--------FGNSDRYHKGAGSRLT 516          

Query:  424 DVIFGPICDYVIAPIARL-MAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARK--IVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGY-NIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPY--IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPV--NGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 3528
            +VIFGP+ D+ +A  AR   A +N P++      +  S D++ E+  LTRV   + D    ++       Y W   +           +      +G   + G  +  I++ + +K   +L    + ++  + +  ++++ +   I ILC DP++VR IML A  LN +NG+Y F N+D+ SSQ  ++RPWYR+    EENE A++A+R LMT+TL KP+  +Y+ F+ EV+ RA  +Y+F+  +  V  F+ +FHDAV LYAL LND L+KGG I +G L+ + MWNR+F+ +   V I  +GDR AD+SL+D+N  TG FEVV NY G  +    V  + IDW   +N+ PL TP CG+D S C    + +IG + A V    + ++++ G+  +RR KFQAEL AMNWIIPWD L+ +EK  R++           +R S+I + N+         D L+  S E                                        T    N     +   + K+      +VALKP+    ++E +  L IE+KK+KD++ DHICR IGVCL+ P+  IVYEYCPKGSL+DVL  EQIKLDWMFK+SLMQDICRG++YLH   GPHGNLKSSNCLVDSRFVLKITDFGLP ++G           +++++ LWTAPELL   +  +    +IKGDVYSFA++CQEIVYR GVF +    N     I ++V+    PPFRPTL   +GC++D+++LI QAWD+DP+ RPDF +IKL MRKLNK GD+ N+LDNLLSRMEQYANNLE LV +RT QYLEEK+K EDLLYSMLP+ VA QL +NQ V AES++MVTI+FSDIVGFT+LSAESTPMQ++ELLNRLYT FD IIEN+D YKVETIGDAYMV SGLPQ NGN H+RE+ARMSIAFL+AI  F IPHRP+K+LELRIGIHSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLPLKIHISQ T ++L TF +FI++ERG +++KGKG Q TYWLHGED  IVDP+P
Sbjct:  146 NVIFGPLNDFTLANAARFSTAMYNVPIVAPAGFAHQLS-DKL-EYGMLTRVLFTYSD--LEWVFGNTLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQHLILQKFLVKAAYKLLSVTLDDEFDVTDRFLKRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEYRTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHNSHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEKHLRRY-----------RRESDIRSPNQ-------SSDPLRKISSETC--------------------------------------TAAAANSQMFARTAFYMKS------IVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLESEVGSFIFHRNLLWTAPELLPDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKPPFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIP 1122          

Query:  355 DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKD----------AYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAK-MEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPK----PGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDD-----LETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMY--YKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            DS+C +T  PL +++  +V    DV FGP+CDY +APIAR   +WN PVI+ GA   AF  D   E+  LTR+   +        + E+   + W      F ++           Y +  P++      Y +K   K    +  + + E  PN+          L+ +      I +LCA  D VR IM++A  LNF NGEY+FLNID+FSS++  E+PWYR+D   E NE A+KA+  LMT+TLRKP   +YK FS EVK+RA+  + NFT   E VNSFV +FHDAVILYA+ LN+TL++   I +G  + K MWNR+F+ +  TV+I  +GDR AD+SL+D+N + G FEVV+NY G  ++YKP  DK I W    N  P DTPTCG+D S CP     P Y I  I   V+G+ + I ++   FI+R  K +AEL  MNW + W+D     +E  +K +R+ S                       ++SL +   L   +         +DT                     S++  + L T  G      +K  + A  ++ K +L   KP+ +             +K+IKD+ NDHI RFIG C+D P   I+ EYC KGSL+DVL  EQIKLDWMF+YSLMQDI RGM YL N+    HGN+KS+NC+VD RFVLKITDFGL +L+G   ++   E  MY  Y++ LWTAPELL +   P  GT KGDVYSFA+ICQEIVYR+GVF L  + +L+ +EI +KV+N   P FRPTL   D   D++ ++I++ W EDP  RPDF  +K  +RKLNK GD GNILDNLLSRMEQYANNLE LV +RT  YLE+K+KAEDLLY MLPK VA  L++ +   AE+Y+ VTI+FSDI GFTA+S+ESTPMQ+++LLN LYT FDS+IEN+DVYKVETIGDAYMV SGLP  NGNLH+REIARMSI+ L A   F I HRP+++L+LRIGIH+GPV +GVVGLKMPRYCLFGDTVNT+SRMESNGLPL+IH+S  TKE+LDTF TF +  RG +++KGKG  +TYWL GE
Sbjct:   92 DSECSETIGPL-KAIDLYVDRDVDVFFGPVCDYAVAPIARFSGYWNIPVISAGATVKAF--DNKTEYRLLTRIQGAYAK--NAEFVLEVAKAFNWTNVGLFFHENMGGGRKGKSNCYFTVEPIF------YKLKNQLKFQPKY--EQFDENFPNEYDFGE-----LLLKASTYTRIVVLCASADSVRDIMIKAHELNFDNGEYVFLNIDLFSSKNESEKPWYREDDTAERNEKARKAYEALMTVTLRKPTSPEYKHFSEEVKKRAESKDRNFTYGEEEVNSFVGAFHDAVILYAIALNETLTRNLSITNGTEITKLMWNRTFDGITGTVSIDDNGDRNADYSLLDMNPKNGKFEVVANYYGNNKEYKPEPDKKIYWAGGRNSPPPDTPTCGFDGSKCPPSEPFPEYGIVII---VLGSLLVIVLVTAFFIYRHIKLEAELAEMNWRVRWEDIMFGSMENDKKLKRQGS-----------------------SVSLNRKMSLASST-------CSVDTIAVHL----------------SDVGQRQLFTKTG-----YYKGAIMAIKSIHKTSLTVNKPLLIE------------VKRIKDLQNDHIVRFIGACIDPPNMCILTEYCQKGSLQDVLENEQIKLDWMFRYSLMQDILRGMTYLFNSDIRSHGNMKSTNCVVDGRFVLKITDFGLHALRGPPDDV---EEGMYAFYRTQLWTAPELLRMHYRPPEGTQKGDVYSFAIICQEIVYRSGVFYLA-NLDLSPEEIHQKVKNGLKPYFRPTLEEADCPCDELAEVIRKCWSEDPMERPDFQALKSTIRKLNKDGDKGNILDNLLSRMEQYANNLEALVEERTSDYLEQKKKAEDLLYMMLPKSVACNLMRGEICHAETYNCVTIYFSDICGFTAMSSESTPMQVVQLLNDLYTAFDSVIENFDVYKVETIGDAYMVVSGLPMRNGNLHAREIARMSISLLNATMSFKIRHRPNEQLKLRIGIHTGPVVAGVVGLKMPRYCLFGDTVNTTSRMESNGLPLRIHVSPCTKEVLDTFTTFDLELRGPVEMKGKGTVITYWLKGE 1077          

Query:  355 DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARL--MAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGY--LISELFSKYKWNKG--KYIFFKDAYNSTIP--------------MYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGG--KIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEK---RRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESN------ISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINV-NGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMY-YKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLT----PDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDD--------VLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPL 3525
            DS C  +  P+   ++  +++  D++ GP C + +A +AR   M  + RP++TTG +  A      AE+  L RVG      + G   ++  +F ++ W     + I F +  +  +               + CHG+  + V+  + IV+    ++  E+H    K  S I  ++ ++I     + +LCADPD VR+IM++A  L FINGEY+F NID+FSS+ +  +PW R++  +E NE A +A+R LMTITLRKP   +Y+ FS +VK  AK +YNFT   E VNSFV +FHDAVILYAL +NDT+ + G   I +G L+ + M NR+FE +  TV+I+ +GDR AD+SL+D+++ T  F VV++Y G ++KY+ V  K IDW   +N  P D P CG+D S C +    +   +  V+   + +  +    I+R+ + ++EL+AMNW IPW +LE  E+    RR    G +     ++   +  +++        +  + + +S+   +       S  +     K R    +++D+ +      +S  S+DTI G+ L  +   QLF KTA +KG LVALKP+++ N +IE+T +LL+E+K++KD+++D++ RFIG CLD P   +V EYCPKGSL+DVL  + + LDWMFK+SLM DICRGMIYLH+N G HGNLKSSNCLVDSRF LKI DFGL SL+G K     E+     Y++ LWTAPELL    PP  GT +GDVYSFA+ICQEI+YR GVF ++    P+P    +EI EKV+   +  +RPTL   D  T+D        ++  ++  W EDP +RP F +IK  + + NK  ++GNILDNLL RMEQY+NNLE LVAKRT+ YLEEK+KAE+LLY MLPK VA  L++ ++V AE +D VTI+FSDI GFTALS+ESTP++++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NG LH+REI+RM+++FLQ I  F I H+PD +L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T EIL+  G F+ + RG +++KGKG QLTYWLHGE  +IVDP+
Sbjct:   34 DSKCDYSVAPVLGVLL--LQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRDK--AEYFNLIRVGPS----FDGVEKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQ-EKYIVR----RLQYEMHNAQFK--SEIFRVMRDEI----RLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIAVIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHR---GQSHQKRTDSVRILF-----GNSHNEGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEP----QEIVEKVKEISNQMYRPTL---DAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPV 1103          

Query:  436 GPICDYVIAPIARLMAFW--NRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKW----NKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKN---WPIKVYTELHPNDIKN---DSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGG--KIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAI-AIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEK---RRRKFSD---------GDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINV-NGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSF---LWTAPELL-NLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLT----PDPNLTSKEIFEKVRNK--DSPPFRPTLM-----LTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDP 3522
            GP C + +A +AR   ++   +P+IT+GA   A + +   E++ L RVG  + D     ++  +F +Y W     +   I +     + +        +   +  R  ++N      +    + P    N    S +   + E++     + +LCADPD VR+IM++A  L FINGEY+F NID+FSS+ +  RPWYRK   NE N  A  A+R LMTITLRKP   +Y++FS +VK  AK  Y+F    E VNSFV +FHDAV+LYAL +NDTL+  G   I +G L+   M +R+F+ +  TV+I+ +GDR AD+SL+D+++ T  F VV++Y G  ++Y+ V+ K+IDW + +N  P D P CG+D S C K    +   +  V+   + + +++ GV I+R+ + ++EL+AMNW I W +LE +E+   RRR  +           D+    T+   ++     E + L+ T +++ +           D D +              + K  +   SN S++TI G+ L  +   QLFAKTA +KGNLVALK I + N ++E+  ++L+EIK++KD+++D+I RFIG CLD P   +V EYCPKGSL+D+L  + + LDWMFK+SLM DICRGMIYLH++ G HGNLKSSNCLVDSRF LKI DFGL SL+G+K   + E  +  Y S+   LWTAPELL N S  P  GT +GDVYSF +I QEI+YR GVF ++    P+P    ++I EK+R      PPFRP+L      L       +L +++  W EDP +RP+F  +K  + + NK  ++GNILDNLL RMEQY+NNLE LVA+RT+QYLEEK+KAE+LLY MLPK VA  L+K ++V AE +D VTI+FSDI GFTALS+ESTPM+++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NGNLH+REIARMS++FL+ I  F I H+PD +L+LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T  IL+  G F+ +ERG +++KGKGLQ TYWLHGE+ NIVDP
Sbjct:   37 GPFCTFCLAAVARYNRYYLYQKPIITSGA---AANLEDKEEYYNLIRVGPMNFD--IENMLLAIFQRYNWLPRQQQNLLIIYVPDDETQLHKQRDETRVTFSRLLRTTIENRFSHQHRYILRVKPYSATNKHFQSEVFRCMREEV----RLVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGV-IYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNEQQQQ----------DEDPAI-------------APKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKE--LKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEP----QDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1071          

Query:  421 PDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHP------------------NDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGG--KIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAI-AIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEK---RRRKFSD---------GDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINV-NGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSF---LWTAPELL-NLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLT----PDPNLTSKEIFEKVRNK--DSPPFRPTLM-----LTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDP 3522
            P  I G  C Y +  + + M      V++TGA+     S  +       R+G+   + Y   L + + +  +W+   Y+   +     +P Y      YL     K+++   +  + +L P                  ND    S    +L E++  K ++ +LCADPD VR+IM++A  L FINGEY+F NID+FSS+ +  RPWYRK   NE N  A  A+R LMTITLRKP   +Y++FS +VK  AK  Y+F    E VNSFV +FHDAV+LYAL +NDTL+  G   I +G L+   M +R+F+ +  TV+I+ +GDR AD+SL+D+++ T  F VV++Y G  ++Y+ V+ K+IDW + +N  P D P CG+D S C K    +   +  V+   + + +++ GV I+R+ + ++EL+AMNW I W +LE +E+   RRR  +           D+    T+   ++     E + L+ T +++ +           D D +              + K  +   SN S++TI G+ L  +   QLFAKTA +KGNLVALK I + N ++E+  ++L+EIK++KD+++D+I RFIG CLD P   +V EYCPKGSL+D+L  + + LDWMFK+SLM DICRGMIYLH++ G HGNLKSSNCLVDSRF LKI DFGL SL+G+K   + E  +  Y S+   LWTAPELL N S  P  GT +GDVYSF +I QEI+YR GVF ++    P+P    ++I EK+R      PPFRP+L      L       +L +++  W EDP +RP+F  +K  + + NK  ++GNILDNLL RMEQY+NNLE LVA+RT+QYLEEK+KAE+LLY MLPK VA  L+K ++V AE +D VTI+FSDI GFTALS+ESTPM+++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NGNLH+REIARMS++FL+ I  F I H+PD +L+LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIHIS  T  IL+  G F+ +ERG +++KGKGLQ TYWLHGE+ NIVDP
Sbjct:  122 PRFIVGVPCSYPMNNVQQYMLQPTDAVVSTGAI-----SSNLVNMKQTIRIGTTADEIYKA-LRAFIRNLGRWSGMFYVTMNNVMTKRLPHY------YLDFVQCKLIQQ-ALDHHLKLEPSFRYEYVYVDSLIEEGRQNDSSTSSLYRRILHERVSTKFSVVVLCADPDTVREIMIKAHELGFINGEYVFFNIDLFSSERLTSRPWYRKTDSNERNAAASVAYRALMTITLRKPNSTEYRDFSDKVKAAAKQNYSFEYPEEEVNSFVGAFHDAVLLYALAINDTLATHGLAGISNGSLITSRMKSRTFKGITGTVSINANGDRNADYSLLDMDKNTKNFTVVAHYYGNTKRYELVSGKVIDWFSKDNLPPPDVPKCGFDNSRCKKDLSEMAIYAVIVLLVLICVLSVLIGV-IYRKLRLESELHAMNWRIAWSELEPTERLAARRRSMASQSSRLRERPSDSGAQRTQTFGNHQQEGEEAQPLNPTPNEQQQQ----------DEDPAI-------------APKGSDVVSSNDSVETIAGVPLSQIPVAQLFAKTAYYKGNLVALKQIYLRNKRLEVNNKILMEIKRVKDLASDNIVRFIGACLDSPNECLVTEYCPKGSLQDILENDNLNLDWMFKFSLMLDICRGMIYLHHSFGSHGNLKSSNCLVDSRFSLKIADFGLHSLRGSKE--LKERDDSDYSSYRNKLWTAPELLRNPSTAPAEGTREGDVYSFGIIAQEIIYRKGVFYISDYDFPEP----QDIIEKIRQPVGSQPPFRPSLSQELVDLDGERVQALLGIVRSCWHEDPNARPNFNAVKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVARRTDQYLEEKKKAENLLYCMLPKQVATTLMKGESVTAEWFDSVTIYFSDICGFTALSSESTPMEVVNLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPGRNGNLHAREIARMSLSFLRNIFSFKIRHKPDAQLKLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSLTYAILEEIGGFVTTERGEVEMKGKGLQKTYWLHGENDNIVDP 1163          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q+FAKTA FKGN+VA+K +N   +IE+T ++L E+K ++D+ NDH+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMFKYSL+ DI +GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S +   T    E+ + YY   LW AP+LL +SNPP  GT KGD+YSF +I QE+  R GVF +  D +L+ KEI ++V   + P  RPT+  T   ++++ +L+Q+ W E+P  RP+F+ IK+L+RK N+   + +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ +IL  F  F +  RG +++KGKG   TYWL GE  +
Sbjct:  563 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFR---TESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGD-SLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1070          

Query:  136 CREGSEALEKTNQGCDLVRPNRDYPLAML--LLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPI-------DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNML------------IEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF----SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            C   +    K++   +  R N ++ +  L  +LPK  +++PWA   P +   ++   K+ N NP +     L  +       D  C ++  PL    + F  E P    GP CDY  +P+      W  P+IT GA    FS DR   + ++T  G  H  K  G     +   + W++   + F D+       Y      + V+G           +YTEL   +I   +T+D +             +++I  +  +  +C  PDI R++M+     N    E++F+ ID+F    +SQ +  +PW R D    ++E+AKKA++++  +T R+P+  +YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++L++       + + + MWNR++  +   V I   GDR  DF+L D+ +  + +F++V+ Y G +++ + +      W      IP D P CG+  D   C      +  + + V+   + I     VFI+R+ K + EL A  W I W+D++ S
Sbjct:   23 CCPTTHTHAKSSHTHESHRHNHNHEIIKLAVILPKTNTSYPWAW--PRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHE-PWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFS-DRSDAYTSITNTGPTH--KKLGEFALHICRHFGWSQHALLMFGDSKMGERECY------FAVEG-----------LYTELKEVNI---TTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPV--QPWARGD---ADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 530          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q+FAKTA FKGN+VA+K +N   +IE+T ++L E+K ++D+ NDH+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMFKYSL+ DI +GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S +   T    E+ + YY   LW AP+LL +SNPP  GT KGD+YSF +I QE+  R GVF +  D +L+ KEI ++V   + P  RPT+  T   ++++ +L+Q+ W E+P  RP+F+ IK+L+RK N+   + +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ +IL  F  F +  RG +++KGKG   TYWL GE  +
Sbjct:  563 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFR---TESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGD-SLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1070          

Query:  136 CREGSEALEKTNQGCDLVRPNRDYPLAML--LLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPI-------DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNML------------IEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF----SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            C   +    K++   +  R N ++ +  L  +LPK  +++PWA   P +   ++   K+ N NP +     L  +       D  C ++  PL    + F  E P    GP CDY  +P+      W  P+IT GA    FS DR   + ++T  G  H  K  G     +   + W++   + F D+       Y      + V+G           +YTEL   +I   +T+D +             +++I  +  +  +C  PDI R++M+     N    E++F+ ID+F    +SQ +  +PW R D    ++E+AKKA++++  +T R+P+  +YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++L++       + + + MWNR++  +   V I   GDR  DF+L D+ +  + +F++V+ Y G +++ + +      W      IP D P CG+  D   C      +  + + V+   + I     VFI+R+ K + EL A  W I W+D++ S
Sbjct:   23 CCPTTHTHAKSSHTHESHRHNHNHEIIKLAVILPKTNTSYPWAW--PRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHE-PWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFS-DRSDAYTSITNTGPTH--KKLGEFALHICRHFGWSQHALLMFGDSKMGERECY------FAVEG-----------LYTELKEVNI---TTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPV--QPWARGD---ADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 530          

Query: 1972 VQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            VQ++AKT  +KGN+ A+K +N   +IE+T ++L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D++  E I LDWMF+YSL+ DI +GM +LHN+    HGNLKSSNCLVDSRFVLKITD+GL S +  K + + E+ + YY   LWTAPEL+   N    GT KGDVYSF +I QE+    GVF L   P  + KEI E V     P  RP L+ T   ++++ +L+Q+ W ED   RPDF  IK+++ K N+G  + NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTA+SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+ EIARMS+A L+A+  F I HRPD +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S++T+ +L  F  F +  RG I++KGKG   TYWL GE ++
Sbjct:  542 VQIYAKTCYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR--KESYL-EDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLD-SPPFSPKEIVEHVAEGRWPYLRP-LLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHKNNRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGESTS 1050          

Query:  220 LLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSD---CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNM---------LIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF--SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEV---VSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGC-P---KPGYNIGAISAGVMGAFVAI----------AIIGGVFIH------RRTKFQAELNAMNWIIPWDDLETS 1674
            ++LPK  + +PWA     P++   LEKV     + P      +    ++    C  +  PL    + F  + P    GP CDY  +P+AR    W  P++T GA    F+      + ++T  G  H  K  G  +  +   + W+K   + F D  N   P Y      + V+G            YTE+  ++I     + N          LI  I  +  +  +C   D  RK+M++         EY+F  ID+F  S +    +PW R D    ++E AK+AF+++  +T R+P+  +YK F +++KR AK E+NF+ E+ L+N     FHD V+LY+  LN+++ + G    G +V K MWNR+F  +   V +  +GDR  DF+L D+ + ++G++EV   +  Y  +K               + N   +  P C Y  + C P    P     + S  V+  F+++          A  G V +       R+ K + EL A  W + W+D++ S
Sbjct:   29 IILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLVAVDLKFAHD-PWAFIGPGCDYASSPVARFTTHWEVPMVTAGAPALGFNM-----YSSITNTGPTH--KKLGEFVVRMHHNFGWHKYAMVMFHDKKNDDRPCY------FAVEGP-----------YTEMTADNITAKDMVFNEDDEPLSYADLINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPWARGD---ADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEVFIYIHFYTVKK--------------IIFNTTIILLPVC-YTYAVCFPLFFSPLSTFISYSFLVLPFFLSLIVLLRFLFSFAFTGSVPLTPCVLSVRKVKLENELAAQLWRVYWEDIQIS 510          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q+FAKTA FKGN+VA+K +N   +IE+T ++L E+K ++D+ NDH+ RFIG C+D P   IV EYCP+GSL                      +  GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S +   T    E+ + YY   LW AP+LL +SNPP  GT KGD+YSF +I QE+  R GVF +  D +L+ KEI ++V   + P  RPT+  T   ++++ +L+Q+ W E+P  RP+F+ IK+L+RK N+   + +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIARMS+A L A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ +IL  F  F +  RG +++KGKG   TYWL GE  +
Sbjct:  543 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL----------------------VLSGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFR---TESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGD-SLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1028          

Query:  220 LLLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPI-------DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNML------------IEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF----SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            ++LPK  +++PWA   P +   ++   K+ N NP +     L  +       D  C ++  PL    + F  E P    GP CDY  +P+      W  P+IT GA    FS DR   + ++T  G  H  K  G     +   + W++   + F D+       Y      + V+G           +YTEL   +I   +T+D +             +++I  +  +  +C  PDI R++M+     N    E++F+ ID+F    +SQ +  +PW R D    ++E+AKKA++++  +T R+P+  +YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++L++       + + + MWNR++  +   V I   GDR  DF+L D+ +  + +F++V+ Y G +++ + +      W      IP D P CG+  D   C      +  + + V+   + I     VFI+R+ K + EL A  W I W+D++ S
Sbjct:   33 VILPKTNTSYPWAW--PRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHE-PWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFS-DRSDAYTSITNTGPTH--KKLGEFALHICRHFGWSQHALLMFGDSKMGERECY------FAVEG-----------LYTELKEVNI---TTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPV--QPWARGD---ADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 510          

Query: 1975 QLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            Q+FAKTA FKGN+VA+K +N   +IE+T ++L E+K ++D+ NDH+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMFKYSL+ DI +GM +LHN+    HGNLKSSNC+VD+RFVLKITD+GL S +   T    E+ + YY   LW AP+LL +SNPP  GT KGD+YSF +I QE+  R GVF +  D +L+ KEI ++V   + P  RPT+  T   ++++ +L+Q+ W E+P  RP+F+ IK+L+RK N+   + +ILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ                       VETIGDAYMV SGLP  NG LH+REIARMS+A L A+  F I HRPD++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG PLKIH+S ++ +IL  F  F +  RG +++KGKG   TYWL GE  +
Sbjct:  582 QVFAKTAYFKGNIVAIKYVN-RKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFR---TESDPEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEGD-SLSPKEIVDRVALGEWPYLRPTVN-TQAHSEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNRE-VSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQ-----------------------VETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESKS 1066          

Query:  136 CREGSEALEKTNQGCDLVRPNRDYPLAML--LLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPI-------DSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNML------------IEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIF----SSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            C   +    K++   +  R N ++ +  L  +LPK  +++PWA   P +   ++   K+ N NP +     L  +       D  C ++  PL    + F  E P    GP CDY  +P+      W  P+IT GA    FS DR   + ++T  G  H  K  G     +   + W++   + F D+       Y      + V+G           +YTEL   +I   +T+D +             +++I  +  +  +C  PDI R++M+     N    E++F+ ID+F    +SQ +  +PW R D    ++E+AKKA++++  +T R+P+  +YK+F  ++K  AK  +NFT ++ L+N     F+D ++LY   LN++L++       + + + MWNR++  +   V I   GDR  DF+L D+ +  + +F++V+ Y G +++ + +      W      IP D P CG+  D   C      +  + + V+   + I     VFI+R+ K + EL A  W I W+D++ S
Sbjct:   42 CCPTTHTHAKSSHTHESHRHNHNHEIIKLAVILPKTNTSYPWAW--PRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLMAVDLKFAHE-PWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFS-DRSDAYTSITNTGPTH--KKLGEFALHICRHFGWSQHALLMFGDSKMGERECY------FAVEG-----------LYTELKEVNI---TTVDLVFEEDSRPVNYSEHLQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPV--QPWARGD---ADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 549          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLE-DVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKG-NKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLI-QQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            G  L +  + Q+FAKT  ++GNLVA+KPIN   KIE+T E+L E+K ++D+ N+H+ RF+G C+D P   IV EYCP+GSL+ D+L  E I LDW+F+YSL+ DI +GM++LHN+  G HG+LKSSNC+VDSRFVLKITD+GL S +  ++   MH   ++Y K  LWTAPELL L +PP  GT KGDVYS  +I QEI  RNG F +    +L+ KEI +KV+N   P FRP+    + C  + L L+ Q+ W EDP  RPDF+ IK+L+ K NK   T NILDNLLSRMEQYANNLE LV +RT+ YLEEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG L+++EIARMS+A L A+  F I HR + KL+LRIGIH+GPVC+GVVGLKMPR+CLFGDTVNT+SRMESNG  LKIH+SQ+TKE+LD FG F +  RG +++KGKG   TYWL GE
Sbjct:  305 GSLLTTQGRNQMFAKTGYYRGNLVAIKPIN-KKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSECEDMH---SLYAKK-LWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYV-EGMDLSPKEIVQKVKNGQRPYFRPST--DESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNKENST-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGE 820          

Query:  859 LCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQ----DIIE--RPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS--EKRRR 1689
             C    + R+ M++A +     G+Y+F  +D FS      ++ E  +PW R D   E +E AK+A++ +M I+ R+P+  +YK+F  ++K+RAK ++NFT E+ L+N    SF+DA+++Y   LN TLS GG + DG  + K+MWNR++  +    TI  +GDR  DFSL DL +  TG F VV +Y G   K   V    I W      IP D P CG++   C   G++   +   V    + I  +    I+R+ K + EL +M W + W++++ S  EK RR
Sbjct:    9 FCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPWKRGD---EFDEQAKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWP--GGSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKARR 289          

Query: 2092 DMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGD------TGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            D+ N+H+ RF+G C+D P   I+ EYCP+GSL+D+L  E I LDWMF+YSLM DI +GM+YLH++  G HGNLKSSNC+VDSRFVLKITD+GL S++ +      +    Y++  LWTAPELL L      GT KGDVYSFA+I QEI  R+G F L  + +LT+KEI ++V+  + P  RPT+    G ++++  L+Q+ W E+ T RPDF  IK+L++K +   D         ILDNLLSRMEQYANNLE LV +RT+ YLEEK KAE LLY +LP  VA QL + + V AE++D VTI+ SDIVGFTA+SA+STPMQ++  LN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  H+ E+ARM++A L A+  F I HRP ++L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRME+ G   +IH+S +TK ILD +G F++   G +D+KGKG   TYWL GE+
Sbjct:   30 DVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKA---DSSANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEAN-HLTAKEIVQRVKLGEWPYLRPTVD-PGGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504          

Query: 2092 DMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNM--YYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDS-PPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            +M ++++  F GVC++ P   IV +YC KGSL+DVL     +LDWMFK S   DI  GMI+LH +    HGNLK S CL+DSR  +K+T FG+   +  K     +  N+  ++    WTAPELL + + PVNGT KGDV+SFA++ +E++Y           +L  K+I ++VR+  + PP RP  +LT+ C   +  LI+Q WDE    RPDF+++  ++R  +  GD  NILDN++S++E+YAN+LE +V  RT Q   EK+K + LL S+LP  V  QL   + V  E Y++VTIFF DIVGFTA+SA STP+++I LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EIA MS+ FL +I  F I H P ++L+LRIGI+SGPV +GVVG  MPRYCLFGDTVN +SRMES G PL IH+S++T  +L   G + + ERG I+LKGKG QLTYWL G+
Sbjct:  246 EMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYHEDEGPYV-GIHLEPKDIIDQVRDGIAVPPLRP--LLTERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDM-NILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717          

Query: 1177 FHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRS---FESLGTTVTISPDGDRYADFSLMDLNQQ---TGMFEVVSN--YIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGV-----FIHRRTKFQAELNAMNWIIPWDDL 1665
             HDA ILYA+ + + L +GG   DG  V++ +   +   F      V+I  +G+R+ D+++ DL ++   TG   + S   +  +   + P   K+   G  + + P D P CG+    C +   +   ++  ++G+ +++ +IG V      + +    Q  ++   W I ++D+
Sbjct:    4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQKM---GWPDGRPPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTVAFLTYLVVQSRSLQESMDTTWWKINFEDI 176          

Query: 2092 DMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNK------TNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDS-PPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            +M ++++  F GVC++ P   IV +YC KGSL+DVL     +LDWMFK S   DI  GMI+LH +    HGNLK S CL+DSR  +K+T FG+   +  K       N   +   +  K   WTAPELL + + PVNGT KGDV+SFA++ +E   R    + T    +   +I ++VR+  + PP RP  +LT+ C   +  LI+Q WDE    RPDF+++  ++R  +  G   NILDN++S++E+YAN+LE +V  RT Q   EK+K + LL S+LP  V  QL   + V  E Y++VTIFF DIVGFTA+SA STP+++I LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EIA MS+ FL +I  F I H P ++L+LRIGI+SGPV +GVVG  MPRYCLFGDTVN +SRMES G PL IH+S++T  +L   G + + ERG I+LKGKG QLTYWL G+
Sbjct:  152 EMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLRMEDLPVNGTPKGDVFSFAILMRESTPREWP-TATRANRVPFPDIIDQVRDGIAVPPLRP--LLTERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 628          

Query: 1975 QLFAKTALFKGNLVALKPIN-VNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRN------GVFSLTPDPNLTSKEIFEKVR-NKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            ++F    +++GN VALK +         +  LL E++ ++++ ++++  F GVC++ P   IV +YC KGSL+DVL     +LD MFK S   DI  GMI+LH +    HGNLK S CL+DSR  +K+T FG+   +  K   + +  N       WT+PELL +   PVNGT KGDV+SF V+ +E++Y        GV       ++  KEI ++VR  K SPP RP  +LT+ C   +  LIQ+ WDE P  RPDF +I  ++R  +  G   +ILDN++S++E+YAN+LE +V  RT Q   EK+K + LL S+LP  V  QL   + V  E ++ VTIFF DIVGFTA+SA S+P+++I LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EI+ MS+ FL +I  F I H P ++L++RIG++SG V +GVVG  MPRYCLFGDTVN +SRMES G PL+IH+S+ST  +L + G + + ERG I LKGKG QLTYWL+G+
Sbjct:  543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKSPIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKKGKIMDVNNQDIAELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGV-------DMEPKEIIDQVREGKCSPPLRP--LLTERCEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHR-SILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGK 1052          

Query:  358 SDCLQTHKPLYESVINFVKEMPDV-IFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRR---AKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRS---FESLGTTVTISPDGDRYADFSLMDLNQQTGMFE----VVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIG 1587
            +DC    K   +S +  V+E   + + GP+C         L A WN P++  G + +    D  A + T  R+ S    +  G ++      + W +   +    A NST             + AR +     IK  T        +D  +    +  I  K  I IL    +  R+++L A SL    G+++FL +  F      E  +++       +    +A   +M  T++      Y+ F  EV+RR        N + + E V+ + +  HDA ILYA+ + + L  GG   DG  +V+ +   +   F  +   V I  +G+R+ D+++ +L ++    +    +V +       + P   K++ W       P D P CG+    C +  Y+   +   +    +A+ ++G
Sbjct:   64 ADCACDAKVSLDSFVTQVREKGIIALLGPVCAEASEVTGLLAAQWNVPML--GFVGHTQRMDSSAVYDTYVRIMSPL--QRMGQMLEATMRHFGWTRAA-MLGGTAQNSTWANIDELWASVERELARSVTITARIKYDT--------SDKVLHRQNLLDISTKARIVILICGSEEAREVLLEAQSLGLATGKFIFLVVQQF------EDSFWKSVAAERLDTQTLQALEPVMLFTIKAYGSSDYELFLQEVRRRLLGPPFYSNLSSDKE-VSPYAAYLHDAAILYAMAVRELLRHGGNPRDGRAIVRTIKGSTKVKFYGVSGQVNIDVNGERFLDYAVFNLQKKGNSSQFLPVMVFDTFQGSISFTPEYQKMV-WP--EGGPPNDMPICGFLGELCQEIPYSGVVLKPALDEPDLALVLVG 461          

Query: 2107 HICRFIGVCL--DHPYIVYEYCPKGSLED-VLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVI 2514
            HICR   +C   +H Y+++EY   G L D ++    I+     K++  + I   +IYLH N+  H +LK  N ++     +KI DFGL ++  ++  +     + +  S  + APELL  +NP     +  DV+SF V+
Sbjct:  205 HICRLFEMCTLSNHFYMLFEYVSGGQLLDYIIQHGSIREHQARKFA--RGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQL-----HTFCGSLYFAAPELLK-ANPYTGPEV--DVWSFGVV 333          

Query: 2095 MSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHE---EPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKD--SPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATI 2727
            MS+ +I +FI    D    YI+ E CP GSL ++L + ++  +   ++   Q IC  + Y+H+    H +LK  N   DS + LKI DFGL ++  N++   +     PN       + APE+L   +     + + D++S  V+   ++     F    D N     I+E+++ +D   P  +P        +D+   LI+     DP  RP    I
Sbjct:  136 MSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPN-------YIAPEVLMGKHS--GHSFEVDIWSLGVMLYALLIGKPPFQAR-DVNT----IYERIKCRDFSFPRDKP-------ISDEGKILIRDILSLDPIERPSLTEI 331          

Query: 2107 HICRFIGVCL--DHPYIVYEYCPKGSLED-VLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIV 2529
            HICR   +C   +H Y+++EY   G L D ++    +K     K++  + I   + YLH N+  H +LK  N ++ S   +KI DFGL ++   +  +     + +  S  + APELL     P  G  + D++SF ++   +V
Sbjct:  184 HICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFA--RGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQL-----HTFCGSLYFAAPELLKAQ--PYTGP-EVDIWSFGIVLYVLV 317          

Query: 2146 YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPP 2619
            YI+ EYC  GSL  ++++    L      + +     G+ YLH     H ++K++N L+ +   +K+ DFG+ ++  +    +    N       W APE+L         +   D++S      E++ +N      P  NLT   I+  V N    P
Sbjct:   96 YILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLN-------WMAPEILG----NRGASTLSDIWSLGATVVEMLTKNP-----PYHNLTDANIYYAVENDTYYP 237          

Query: 2149 IVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICR----GMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRP 2712
            I  EY P GS+  +L          F+ SL+ +  R    G+ YLH  +  H ++K +N L+D +  +KITDFG+ S K +  N    +      S  W +PE++  +      T K D++S   +  E+      F     P+ +  +   K+    +P   P+   ++G        +++A++ D   RP
Sbjct:  531 IFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGI-SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTAT----TAKADIWSTGCVVIEMFTGKHPF-----PDFSQMQAIFKIGTNTTPEI-PSWATSEGKN-----FLRKAFELDYQYRP 701          

Query: 1960 SMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHE-EPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRP---TLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGED 3504
            ++++ Q+F    ++K N+VA+K IN   +IE+T E+  E+K ++ + ++++  F G C++ P   I+ +YCPKGSL+D+L  E IKLD MF  SL+ DI +GM YLH+     HG LKS NC+VD R+VLKITD+GL   K N+     E E  MYY+  LWTAPELL  ++P   GT KGDVYSF +I QE++ R+G F L+   N  S +I EKV   +SPPFRP   T++L       ++ L +  W+E+P  RPDF  I+  +RKL  G  + NI+DN+++ +E+YANNLE LV +RT Q  +EK+K E+LL  MLP  VA  L+  + V AE++D V+IFFSDIVGFT+LS+ESTP+Q+++LLN LYT FD II NYDVYKVETIGDAYMV SGLP  NG+ H+ EIA M++  L+ I  F I HRP+ KL+LRIGIHSG   +GVVG KMPRYCLFGDTVNT+SRMESNG  LKIHIS STK ILD  G + I +RG + LKGKG  +TYWL G D
Sbjct:    1 NINQRQIFTTVGIYKSNMVAIKRIN-KRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRK-LWTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYYTNEPS-DIIEKVTRVESPPFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKLPMGKQS-NIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518          

Query: 2092 DMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLM-LTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKL-NKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISI-FIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWL 3492
            D+ +D++ +FIG C+  P   IV +YC +GSL+D+L  + +KLD +F  SL+ DI +GM YLHN+    HGNLKSSNCLVDSR+VLKITD+GLP L+        E     ++  LW APE+L + + P  GT KGDVYSF++I QE   R+G +S      +  K I EKVR  + PP+RP +  L DG  +++  L++Q W EDP  RPDF  IK  +R++ +K G   NI DN+++ ME YA+NLE LVA+RT+Q ++EK+K + LL S+LP+ VA QL K + V AES++ VTI+FSDIVGFT+LSAESTPMQ++  LN LYT FD II+ YDVYKVETIGDAYMV SGLP  NG  H+ EIA+M++  + A+S  FI+ H+P+ KL+LR+G H+GPV +GVVG  M RYCLFGDTVNT+SRMESNG PL+IHISQ TK++LD  GTF++  RG + LKGKG   T+WL
Sbjct:   28 DIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIE---TNWRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYSAN---YMEPKAIIEKVRKSEFPPYRPIVANLIDGA-EELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493          

Query: 2092 DMSNDHICRFIGVCLDHPYI--VYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSN---PPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTL--MLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 3528
            D+ + ++ R++GVC++ P I  V  +C +G+L+D+L  + IKLDWMF+ S   DI  GM  +HN+    HGNLKSSNCL+DSR+  KITD+GL  L+ N+T     E  +Y K+  WTAPELL L++      N T  GDVYS+ ++  EI+ R+  +S   D  L+SK++ E VR +  P FRP     + +     ++++ Q  WD D   RP F+ IK   +KL   G     +  + SR   Y NN   LV  R    +  K+    LL  +L + +A +L K  +V AES+  VTIFFSDIVGFT+++A+STP+Q+++LLN+LYT FD +++ +DVYKVETIGDAYMV SGLP  NG  H+ E+A M++  L  +  F IPH P +K++LRIGIHSG   +GVVGLKMPRYCLFGDTVN +SRMES+GL L+IH+S   KE+LD  G + + ERG + +KGKG  +TY+L G+D     PLP
Sbjct:    6 DLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGEFAVY-KNLFWTAPELLPLADGFKDRKNKTQAGDVYSYGIVLYEIITRDEPYSTNTD-TLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIK---KKLKANGMGNGKISGMFSR---YYNNFSKLVISRMGVCMALKR----LL--VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKD-GFDKPLP 477          

Query: 2188 VLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSN---PPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTL--MLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLK 3462
            +L  + IKLDWMF+ S   DI  GM  +HN+    HGNLKSSNCL+DSR+  KITD+GL  L+ N+T     E  +Y ++  WT PELL L++      N T  GDVYS+ ++  EI+ R+  +S   D  L+SK++ E VR +  P FRP     + +     ++++ Q  WD D   RP F+ IK  + K N  G   NI+DN+++ M +Y + LE +V +RT+Q  EEK K ++LLY MLP+ +A +L K   V AES+  VTIFFSDIVGFT+++A+STP+Q+++LLN+LYT FD +++ +DVYKVETIGDAYMV SGLP  NG  H+ E+A M++  L  +  F IPH P +K++LRIGIHSG   +GVVGLKMPRYCLFGDTVN +SRMES+GL L+IH+S   KE+LD  G + + ERG + +K
Sbjct:    2 LLGNDSIKLDWMFRQSFANDIATGMEAIHNSPIQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPKDIGEFAVY-RNLFWTVPELLPLADGFKDHKNKTQAGDVYSYGIVLYEIITRDEPYSTNTD-TLSSKDVIELVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKL-KANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429          

Query: 2095 MSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGP-HGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLE-----------LRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDS-NIVDPLP 3528
            +S+ +I  +IGVC+  P   IV E C +GSL DVL  + IKLDW FK S   DI  GM  LH +    HGNL SSNCLVD  +V KI D+GL     +      +      KS LW APE  ++ N    G+  GDVYSF VI  EIV R   F         +  I  ++ + + PP RPTL   D C   + K I+Q W E+P++RP F  IK  MRK+N GG +  ++D++L +M+ Y+NNLE LV +RT Q   EK K + LLY MLP+ VA QL   ++V AE +D VT+FFSDIVGFT LS+ STP+Q++  LN LYT FD+II NYDVYKVETIGDAYMV SGLP+ N + H+ EIA M++  L  I  F I H PD +L            L   I SGP  +GVVG+K PRY +FGDTVN +SRMESNG+P +IHIS   ++ L   G + +  RG I+LKGKG  +TY+L+G+D  N V P P
Sbjct:    5 LSHVNINPYIGVCITAPNICIVSEACGRGSLADVLINDDIKLDWTFKMSFATDIAAGMEALHASEVSFHGNLTSSNCLVDRMWVCKIADYGLQRFSKHTYEPEEQLTGQTGKS-LWMAPE--HMRNASSTGSQPGDVYSFGVILSEIVTRCEPFETL----RATTSILRRIMSTEFPPLRPTLN-ADDCDPTITKFIKQCWSEEPSARPTFRDIKKSMRKIN-GGRSLRLVDSMLGKMDIYSNNLEVLVEERTRQLEAEKAKTDQLLYEMLPRPVADQLKSGKSVEAELFDQVTVFFSDIVGFTKLSSSSTPIQVVTFLNDLYTYFDNIIPNYDVYKVETIGDAYMVVSGLPEKNRDRHAGEIATMALHLLCDIRTFKIRHVPDTRLVSSYSLLLIITCLFYLIFSGPAVAGVVGIKKPRYDVFGDTVNVASRMESNGVPNRIHISAECRKALLNLGGYHMERRGEIELKGKGKVITYFLNGKDGFNRVRPEP 488          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDG--CTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNI 3513
            G  + +  K QLFAKT  FKGNLVA+K +N   +IE+T ++L+E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMF+YSL+ DI +GM +LHN++ G HGNLKSSNC+VDSRFVLKITD+GL S + +  N   ++ +  Y   LWTAPELL   + P  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT   TD    ++++  L++  W EDP  RPDF  IK+ M KLNK G T +IL+NLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIA MS+A L+ +  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TKE+LD F  F +  RG +++KGKG   TYWL GE +++
Sbjct:  482 GSLITAQGKYQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---DDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQKVRNGQRPYFRPT---TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGST-SILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1000          

Query:  928 EYLFLNIDIFSSQDIIERPWYRKD---------RPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGV--MGAFVAIAIIG--GVFIHRRTKFQAELNAMNWIIPWDDLE 1668
            E +F+N+    +  +  RP+  +          + N  ++   +   ++  IT   P+  +YK+F  ++  RA+ ++    E  L++    SF+D  +LYA+ L++TL++GG   +G  + +   NRSF  +   V+I     R  D  L  + NQ+TG + VVS Y G  ++      + I W +     PLD P C +       P  N G    G+  +G+ +A+ I G     I+R+ K + EL  M W + W+DL+
Sbjct:  202 EGIFMNLKDEMNMTVSARPYTNEQDYKELVSFIKENGRSKFTHQYDTSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP--PLDNPPCVFSTD---DPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQ 457          

Query:  214 AMLLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDS-----DCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYL 720
            A ++LP N+  +PWAL    P++ M  E +     +        + Y  ++      C ++   +   V   +   PDV FGP C Y +A + R ++ W  P+IT G   Y F  +++ E+ T+ R+G        G  ++ L +++ W     + F D      P Y    GI++
Sbjct:   36 AAVMLPDNYHKYPWALPRVFPALLMAQEDLHTKHKLLLGHTITILNYSTENPAAPGSCAESRAQVV-VVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGF--EKLDEYKTIVRIGPSTTK--LGAFVNVLHTQFNWTSRAVVIFYDLKQDDRPHYFLSEGIFM 206          

Query: 1945 GINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDG--CTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNI 3513
            G  + +  K QLFAKT  FKGNLVA+K +N   +IE+T ++L+E+K ++D+  +H+ RFIG C+D P   IV EYCP+GSL+D+L  E I LDWMF+YSL+ DI +GM +LHN++ G HGNLKSSNC+VDSRFVLKITD+GL S + +  N   ++ +  Y   LWTAPELL   + P  GT KGDVYSF +I QEI  RNG F +    +L+ KEI +KVRN   P FRPT   TD    ++++  L++  W EDP  RPDF  IK+ M KLNK G T +IL+NLLSRMEQYANNLE LV +RT+ YLEEK+KAE+LLY +LP  VA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH+REIA MS+A L+ +  F I HRP+ +L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG  LKIH+S +TKE+LD F  F +  RG +++KGKG   TYWL GE +++
Sbjct:  534 GSLITAQGKYQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCEN---DDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQKVRNGQRPYFRPT---TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEGST-SILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGEKTDV 1052          

Query:  214 AMLLLPKNFSTFPWAL--TIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDS-----DCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGV--MGAFVAIAIIG--GVFIHRRTKFQAELNAMNWIIPWDDLE 1668
            A ++LP N+  +PWAL    P++ M  E +     +        + Y  ++      C ++   +   V   +   PDV FGP C Y +A + R ++ W  P+IT G   Y F  +++ E+ T+ R+G        G  ++ L +++ W     + F D      P Y    GI++     K   N  +      +  D K        L+  I     I  +C   +    IM    S       Y    +D+F+      +PW +  + +  N I  + F+++  IT   P+  +YK+F  ++  RA+ ++    E  L++    SF+D  +LYA+ L++TL++GG   +G  + +   NRSF  +   V+I     R  D  L  + NQ+TG + VVS Y G  ++      + I W +     PLD P C +       P  N G    G+  +G+ +A+ I G     I+R+ K + EL  M W + W+DL+
Sbjct:   36 AAVMLPDNYHKYPWALPRVFPALLMAQEDLHTKHKLLLGHTITILNYSTENPAAPGSCAESRAQVV-VVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGF--EKLDEYKTIVRIGPSTTK--LGAFVNVLHTQFNWTSRAVVIFYDLKQDDRPHYFLSEGIFM---NLKDEMNMTVSARPYTNEQDYKE-------LVSFIKENGRIIYICGPLETFLSIMKLFQSEIQDPESYAIFYLDVFAESLTHRKPW-QNAKFDWTNPI--QVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP--PLDNPPCVFSTD---DPSCNDGLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRVQWEDLQ 509          

Query: 1972 VQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            +Q++ KT  +KGNLVA+K IN   +IE+T  +L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D++  E + LDWMF+YSL+ DI +GM +LHN+    HGNLKSSNC+VDSRFVLKITD+GL SL+   T+   ++ + YY   LWTAPELL   +PP+ GT KGDVYSF +I QE+    GVF +     L  KEI + V     P  RP+L      ++++  L+Q+ W E+P  RPDF TIK+L+RK ++G  + NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH RE+ARM++A L A+  F I HRP ++L LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES G  LKIH+S++T+++L  F TF +  RG I++KGKG   TYWL GED++
Sbjct:  545 LQIYTKTGYYKGNLVAIKYIN-KKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLR---TSSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTH-TLIPKEIIQGVIRGGVPLLRPSLCFHSH-SEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDNS 1053          

Query:  421 PDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNA-INILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERP---WYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGG------KIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            P    GP CDY  +P+AR    W+ P++T GA      +D  ++F  +T  G  H  K  G    ++   + W+    + F D  +      C+    + ++G   ++    I V+      D   +S I++  + QI  KN  +  LC   D +R +M++          Y+F  ID+F+     E+P   W+R D   +++  A+ AFR++  +T  +P+  +Y +F   +K+ A+  +NFT ++ L N     F+D V+LY+  LN+TLSK        +   G++V + MWNR+F+ +  TV +   GDR  DF+L D+    +G FEVV  Y    ++   V  K +++       PL+ P CG+  D   C      +  + A V+     I I   +FI+R+ K + EL A  W + W D++ S
Sbjct:  105 PWAFIGPGCDYSSSPVARFTTHWDVPMVTAGA-----RADGFSKFAAVTNTGPTH--KKLGEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCY----FAIEGLYSLMGKHNITVF------DYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGD---QDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKEL--VLQKGLNFQWPGGSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMS 513          

Query: 1972 VQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSN 3510
            +Q++ KT  +KGNLVA+K IN   +IE+T  +L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D++  E + LDWMF+YSL+ DI +GM +LHN+    HGNLKSSNC+VDSRFVLKITD+GL SL+   T+   ++ + YY   LWTAPELL   +PP+ GT KGDVYSF +I QE+    GVF +     L  KEI + V     P  RP+L      ++++  L+Q+ W E+P  RPDF TIK+L+RK ++G  + NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D VTI+FSDIVGFTALSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH RE+ARM++A L A+  F I HRP ++L LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES G  LKIH+S++T+++L  F TF +  RG I++KGKG   TYWL GED++
Sbjct:  486 LQIYTKTGYYKGNLVAIKYIN-KKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLR---TSSCPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTH-TLIPKEIIQGVIRGGVPLLRPSLCFHSH-SEELGVLMQRCWCEEPGERPDFNTIKILLRKQHRGYGS-NILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDNS 994          

Query:  421 PDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNA-INILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIER---PWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQ-QTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            P    GP CDY  +P+AR    W+ P++T GA      +D  ++F  +T  G  H  K  G    ++   + W+    + F D  +      C+    + ++G   ++    I V+      D   +S I++  + QI  KN  +  LC   D +R +M++          Y+F  ID+F+     E+   PW+R D   +++  A+ AFR      +R P                           + NSF         +Y L    T     +I   ++  + +W      +  TV +   GDR  DF+L D+    +G FEV         K+ P   K +++       PL+ P CG+  D   C      +  + A V+     I I   +FI+R+ K + EL A  W + W D++ S
Sbjct:  105 PWAFIGPGCDYSSSPVARFTTHWDVPMVTAGA-----RADGFSKFAAVTNTGPTH--KKLGEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCY----FAIEGLYSLMGKHNITVF------DYFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGD---QDDHAARLAFR------VRHP--------------------------SIFNSFS--------VYNLSTTITPQSFMQI---KMCSEPVWCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKFEV---------KHLP---KGLNFQWPGGSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMS 454          

Query: 1972 VQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNH-GPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 3501
            +Q+FAKT  +KGN+VA+K  N   +IE+  ++L E+K ++D+ N+H+ RFIG C+D P   I+ EYCP+GSL+D+L  + I L+WMFK+SL+ DI +GM++LHN+    HG LKSSNC+VD+RFVLKITD+GL + +  + + +  + + YY   LW APELL + NPP  GT KGDVYSF++I QE+  R G F L  DP L+ KEI ++V   D P  RP++      + ++ +L+Q+ W E+PT RPDF  I+LL+RK NK   T NILDNLLSRMEQYANNLE LV +RT+ Y EEK+KAE LLY +LP  VA QL + + V AE++D V+I+FSDIVGFTALSAESTPM+++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L  +  F I HRP+++L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMES+G  LKIH+S +T+++L  F +F +  RG ID+KGKG   TYWL GE
Sbjct:  553 LQVFAKTGYYKGNIVAIKYTN-KKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFR--QESDVGSDSHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDGDP-LSPKEIVDRVILGDWPCLRPSID-PQSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGE 1059          

Query:  190 RPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEK-VRKMEXXXXXXXXXXXLYPIDSD------CLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTID-NMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDL-NQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGY--DLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETS 1674
            RP ++  LA ++LP+  + +PWA   P I   LE+ + K+ +   ++ N  + Y   S       C ++  PL    + F  + P    GP C Y  +P+      W+ P+IT GA   AF  D I  + T+T  G  H  K  G     +   + W +   + F D      P Y    G+Y  +  + I  +    V+ E       N   I+ + ++  I N   +  +C  PD+ R++M+     +  + +Y+FL ID+F+     ++PW R D   +++ IAK AF+++  ++ R+P+ ++Y++F  ++K  AK  +N++ ++ L+N     F+D ++LYA  LN+T    G    G+L+   MWNR+F  +   + +   GDR  DF+L DL +  +  F++V  Y   + +  PV    + W  +    PLD P CG+  D   C      I  + +  +     + +   +FI R+ K + EL A  W I WDD++ S
Sbjct:   40 RPRQNITLA-IILPETNTAYPWAW--PRIGPALERAIIKINSDPNLLPNHHLTYVFKSSENSNGICSESVAPLVAVDLEFAYK-PWAFIGPGCSYTASPVGLFTTHWDVPLITAGAPAIAFL-DGI--YPTITNTGPTH--KKLGRFALRICEHFGWREYVTLMFSDNKEDDRPCYFAMEGLY--EELKSINISLQDSVFEE-------NKPPINYSQILADIQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPWARGD---QDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRW--LGGARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQMS 522          

Query:   70 MFFQSVKTMFFHCLLTGFIISLCREGSEALEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD 3534
            MFFQSVKTMFFHCLLTGFIISLCREGSEALEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMENINPIIKNIKILYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLDHPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD
Sbjct:    1 MFFQSVKTMFFHCLLTGFIISLCREGSEALEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMENINPIIKNIKILYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLDHPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD 1155          

Query:  109 LLTGFIISLCREGSEA-LEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKP--GYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSP-PFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD 3534
            +L   +IS    G E       Q C + RP+R YPLAML+LPKNFS FPW LTIP+IK+ LEKV+ M  +NPI+K++K L P+DS C++T+  LY  V  FV +MPDV+FGPIC YV+APIARL+AFWN P+++TGA+YY F  +R +EF TLTR+GSGHLD   G +I + F KYKW  G YI+ K AY + IP+YCH LG YL +     V  WPI+ Y EL    + ND+ ++  LI+ IGNK A+ +LC DP  V +I+L+A  LNF NGEY+F+NI +FSS +  + PWY       EN  AK+A+R+L+++TL+ PE EK++ FS +VK  A  EYN+  E +L+N+FVS+F+D V+LYA  LN TL+ GG I +G L++KNMWN +FE +G TVTI   GDR ADFS++D++ +TG F+ V+++IG K  +  V +  +DWG+V+N IP   P CGYD S CPKP    NIGAISAGVMG    I+   G F++R  K QAELNAMNWIIPW+ LETSEK R   +     H   K +   I N     + S +++ +     +EN +L+ +++    K  + N     N    D   IS  SL+TI GINLD +   QLF KTAL+KGN+VALKPI    +I+I  +LLI++KK+KD++NDHICRFIG CL+  + Y+VY+YCPKGSLEDVLAKEQI LDW+FKYSL+QDICRGM+YLHNN GP G LKSSNCLVDSRFVLKITDFGL SL+G+K  ++ E+ N+Y+K+ LWTAPELL +SNPP++GT KGDVYSFA++CQEIVYR GVFSL  + + +++EI E V+ ++SP PFRP+L    GCT+D + LI+Q+W+EDP  RPDF TIK  MRK NK GD+GNILDNLLSRMEQYANNLE +V +RTEQYLEEK+KAEDLLYSMLPK VAHQLIKNQ V AESYD+VTIFFSDIVGFTALSAESTPMQII+LLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLH+REIARM+IAFL AI  F+IPHRPDK+L+LRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLP KIHISQST ++L TFGTF+++ERGHI++KGKG   TYWLHGE+  IVDP+P D
Sbjct:    1 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVN-----HNCVKYQSKPIHNSKVKVHQSRSQNVKGTRNEMENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKD 1143          

Query:  109 LLTGFIISLCREGSEA-LEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKP--GYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSP-PFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD 3534
            +L   +IS    G E       Q C + RP+R YPLAML+LPKNFS FPW LTIP+IK+ LEKV+ M  +NPI+K++K L P+DS C++T+  LY  V  FV +MPDV+FGPIC YV+APIARL+AFWN P+++TGA+YY F  +R +EF TLTR+GSGHLD   G +I + F KYKW  G YI+ K AY + IP+YCH LG YL +     V  WPI+ Y EL    + ND+ ++  LI+ IGNK A+ +LC DP  V +I+L+A  LNF NGEY+F+NI +FSS +  + PWY       EN  AK+A+R+L+++TL+ PE EK++ FS +VK  A  EYN+  E +L+N+FVS+F+D V+LYA  LN TL+ GG I +G L++KNMWN +FE +G TVTI   GDR ADFS++D++ +TG F+ V+++IG K  +  V +  +DWG+V+N IP   P CGYD S CPKP    NIGAISAGVMG    I+   G F++R  K QAELNAMNWIIPW+ LETSEK R   +   N   Y  K   N          S  K  + + +++EN +L+ +++    K  + N     N    D   IS  SL+TI GINLD +   QLF KTAL+KGN+VALKPI    +I+I  +LLI++KK+KD++NDHICRFIG CL+  + Y+VY+YCPKGSLEDVLAKEQI LDW+FKYSL+QDICRGM+YLHNN GP G LKSSNCLVDSRFVLKITDFGL SL+G+K  ++ E+ N+Y+K+ LWTAPELL +SNPP++GT KGDVYSFA++CQEIVYR GVFSL  + + +++EI E V+ ++SP PFRP+L    GCT+D + LI+Q+W+EDP  RPDF TIK  MRK NK GD+GNILDNLLSRMEQYANNLE +V +RTEQYLEEK+KAEDLLYSMLPK VAHQLIKNQ V AESYD+VTIFFSDIVGFTALSAESTPMQII+LLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLH+REIARM+IAFL AI  F+IPHRPDK+L+LRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLP KIHISQST ++L TFGTF+++ERGHI++KGKG   TYWLHGE+  IVDP+P D
Sbjct:    1 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNH--NCVKYQSKPIHN----------SKVKVHQSRSQNMENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKD 1136          

Query:  196 NRDYPLAMLLLPKNFS-TFPWALTIPSIKMGLEKVRKMEXXXXXXXXXXXLYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRR---KFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNP-PVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 3528
            N DYPLA++++P +    F   L + +  + LEK+R       I K        DSDCL +  PLY +V   +K  P V FGPICDY +APIARL+ FW+ P+IT       F   +  E+ TLTRV S  +  +   L  ++F  Y W++ K I     Y  T   +C  +G        +  KN   K    L+          + +L   +G++NA+ +LC +P+ VR+I+L+A  LNFINGEY+F+NID+ +S+   ++PWY K+  +E N  AK+A+R+L+T+T ++PE E+Y+ F  EVK R   +Y   +E+   N F+  FHD+++LYAL LNDT++     E+G  + + MWNR+ + +   ++I  +GDR AD+S++D+++ TG+F++V+NYIG+K+ Y PV  +IIDW    N  P   P CGY+   CP      G IS   M A +  A+I G +I++R KFQAELNAMNW+IPWD++ET EKR R   K SD         KRF       +     L K DE     I N  L  D+  S+          R NS      NIS  S ++  G+  D++H ++ F  TAL+KGN+VALK ++ + K+EI   LLIE+KK+K+++N+HICRFIGVCLD P  +++ EYCPKGSL+D+L  EQI LDWMFK+SL+QDICRGMIYLH+N GPHGNLKSSNCLVDSRFVLKI DFGL  L+G K  ++  +   YY++ LWTAPE+L  +    +  + K DVYSF +ICQE+VYRNGVF L+ D NL  K+I E V      P+RP L   + C++ + ++I+Q+W ED + RPDF TIK +MR LNKGGD+GNILDNLLSRMEQYANNLE LV +RTEQYLEEK+K EDLLYSMLPK VA QLI+N+ V AESY+MV+I+FSDIVGFTALSAESTPMQ+IELLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARMS+AFL AI  F IPH+P+K++ELRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIH+S+ + ++L TF  FIIS+RG +++KGKG Q TYWLHGEDS IVDP+P
Sbjct:   35 NPDYPLAIIMIPDDIRHNFNKNLMLSAFDIALEKIRTWNIHPFIRKLKYYA-DADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLI-----YEQTFLNFCRSVGTLF---DSENYKNKTFKSVVLLNA---------ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRF-------QYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPS--------RVNSI-----NISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLS-DINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 1110          

Query:  427 VIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKPGYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRR---KFSDGDNFHPYTKKRFSNIMNKNEMENLSLTKDDELKHESIENYYLMTDIDTSXXXXXXXXXXRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGXXXXXXXXXXXXXXXXDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNP-PVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLP 3528
            V FGPICDY +APIARL+ FW+ P+IT       F   +  E+ TLTRV S  +  +   L  ++F  Y W++ K I     Y  T   +C  +G        +  KN   K    L+          + +L   +G++NA+ +LC +P+ VR+I+L+A  LNFINGEY+F+NID+ +S+   ++PWY K+  +E N  AK+A+R+L+T+T ++PE E+Y+ F  EVK R   +Y   +E+   N F+  FHD+++LYAL LNDT++     E+G  + + MWNR+ + +   ++I  +GDR AD+S++D+++ TG+F++V+NYIG+K+ Y PV  +IIDW    N  P   P CGY+   CP      G IS   M A +  A+I G +I++R KFQAELNAMNW+IPWD++ET EKR R   K SD         KRF       +     L K DE     I N  L  D+  S+          R NS      NIS  S ++  G+  D++H ++ F  TAL+KGN+VALK ++ + K+EI   LLIE+KK+K+++N+HICRFIGVCLD P  +++ EYCPKGSL+D+L  EQI LDWMFK+SL+QDICRGMIYLH+N GPHGNLKSSNCLVDSRFVLKI DFGL  L+G K  ++  +   YY++ LWTAPE+L  +    +  + K DVYSF +ICQE+VYRNGVF L+ D NL  K+I E V      P+RP L   + C++ + ++I+Q+W ED + RPDF TIK +MR LNKGGD+GNILDNLLSRMEQYANNLE LV +RTEQYLEEK+K EDLLYSMLPK VA QLI+N+ V AESY+MV+I+FSDIVGFTALSAESTPMQ+IELLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARMS+AFL AI  F IPH+P+K++ELRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLPLKIH+S+ + ++L TF  FIIS+RG +++KGKG Q TYWLHGEDS IVDP+P
Sbjct:   53 VWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLI-----YEQTFLNFCRSVGTLF---DSENYKNKTFKSVVLLNA---------ETLLEIDMGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCPNRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREKRHRLTHKVSDTLPNSELFTKRF-------QYSKRGLAKFDEESDVLIGNPSLAGDVVKSRPS--------RVNSI-----NISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYLS-DINLEPKQIVEFVTKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIP 1051