UBX domain-containing protein 4

Overview
NameUBX domain-containing protein 4
Smed IDSMED30021790
Length (bp)1471
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of UBX domain-containing protein 4 (SMED30021790) t-SNE clustered cells

Violin plots show distribution of expression levels for UBX domain-containing protein 4 (SMED30021790) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of UBX domain-containing protein 4 (SMED30021790) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for UBX domain-containing protein 4 (SMED30021790) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021790

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30021790h1SMcG0000790 Contig2440GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30021790h1SMcG0000790 dd_Smed_v4_823_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30021790h1SMcG0000790 dd_Smed_v6_823_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Human
Match: UBXN4 (UBX domain protein 4 [Source:HGNC Symbol;Acc:HGNC:14860])

HSP 1 Score: 88.9669 bits (219), Expect = 3.227e-18
Identity = 75/264 (28.41%), Postives = 118/264 (44.70%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSN---------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPT----RVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++                 + +ME+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    L       + PPT    RV    PP+  +S    + + E  ++R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  258 KAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFL-----FSNPPPTQTSVRVTSSEPPNPASSSK--SEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 508
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Human
Match: UBXN1 (UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:18402])

HSP 1 Score: 51.6026 bits (122), Expect = 9.924e-7
Identity = 38/140 (27.14%), Postives = 60/140 (42.86%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRYSN--------------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNM-GCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            AR ++  +IE DK ER ++Y                   + P+++      R  D       R+  R PDG+S+   F   E   +VR +V  H    + G ++  ++   FPRR     D +  L +L LVPSA   V+
Sbjct:  101 ARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPP--TKREYDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVA 233
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Human
Match: UBXN1 (UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:18402])

HSP 1 Score: 51.6026 bits (122), Expect = 1.369e-6
Identity = 38/140 (27.14%), Postives = 60/140 (42.86%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRYSN--------------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNM-GCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            AR ++  +IE DK ER ++Y                   + P+++      R  D       R+  R PDG+S+   F   E   +VR +V  H    + G ++  ++   FPRR     D +  L +L LVPSA   V+
Sbjct:  160 ARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPP--TKREYDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVA 292
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Human
Match: UBXN1 (UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:18402])

HSP 1 Score: 50.447 bits (119), Expect = 3.042e-6
Identity = 37/135 (27.41%), Postives = 58/135 (42.96%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRYSN--------------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNM-GCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSA 1019
            AR ++  +IE DK ER ++Y                   + P+++      R  D       R+  R PDG+S+   F   E   +VR +V  H    + G ++  ++   FPRR     D +  L +L LVPSA
Sbjct:  160 ARQRVREKIERDKAERAKKYGGSVGSQPPPVAPEPGPVPSSPSQEPP--TKREYDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSA 287
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Celegans
Match: ubxn-4 (UBX domain-containing protein 4 [Source:UniProtKB/Swiss-Prot;Acc:P34631])

HSP 1 Score: 51.9878 bits (123), Expect = 6.781e-7
Identity = 68/256 (26.56%), Postives = 114/256 (44.53%), Query Frame = 3 
Query:  663 RDKILRQIEDDKMERKQRYS---NQQLAKPNEDKMELKHRNIDNG-ESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMG-CRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAV---------SFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + +IL QI+ D+   ++++    N + A  N +K +     +     S   RL  R PDGS+   +F  ++  +S+ E     IR         FEI+Q +PRR     D   T ++ QL PS +  V         ++ +  +++ ++S  + W L P+       W+IF  ++               +  P ++G SGS       + QRR +   S  + + GNVAG    +   DD E+ A +NGNSTQ M
Sbjct:  235 KKRILAQIKADREAAQKKFGKLVNTENASENTEKKQ--ETTVGKAVPSDRCRLQVRLPDGSTFVEEFPSNDVLNSLVEI----IRQKPSIAGTTFEIQQPYPRRIFTNDDYSKTFLENQLTPSTALVVIQKSSGSSSNYGSFSLSTQTVSF-VTWVLYPLT----AFWNIFCGMIGWNSTGKQQDSKSKKNDGPSTSGQSGS-------QPQRRGM-PRSAEVRRRGNVAGL--ENPNEDDPEERASFNGNSTQFM 469
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Celegans
Match: ubxn-4 (UBX domain-containing protein 4 [Source:UniProtKB/Swiss-Prot;Acc:P34631])

HSP 1 Score: 51.9878 bits (123), Expect = 6.781e-7
Identity = 68/256 (26.56%), Postives = 114/256 (44.53%), Query Frame = 3 
Query:  663 RDKILRQIEDDKMERKQRYS---NQQLAKPNEDKMELKHRNIDNG-ESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMG-CRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAV---------SFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + +IL QI+ D+   ++++    N + A  N +K +     +     S   RL  R PDGS+   +F  ++  +S+ E     IR         FEI+Q +PRR     D   T ++ QL PS +  V         ++ +  +++ ++S  + W L P+       W+IF  ++               +  P ++G SGS       + QRR +   S  + + GNVAG    +   DD E+ A +NGNSTQ M
Sbjct:  235 KKRILAQIKADREAAQKKFGKLVNTENASENTEKKQ--ETTVGKAVPSDRCRLQVRLPDGSTFVEEFPSNDVLNSLVEI----IRQKPSIAGTTFEIQQPYPRRIFTNDDYSKTFLENQLTPSTALVVIQKSSGSSSNYGSFSLSTQTVSF-VTWVLYPLT----AFWNIFCGMIGWNSTGKQQDSKSKKNDGPSTSGQSGS-------QPQRRGM-PRSAEVRRRGNVAGL--ENPNEDDPEERASFNGNSTQFM 469
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Fly
Match: CG8042 (gene:FBgn0027554 transcript:FBtr0076766)

HSP 1 Score: 56.225 bits (134), Expect = 4.613e-8
Identity = 38/131 (29.01%), Postives = 58/131 (44.27%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDNGESG-----GVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSA 1019
            R EE  AR++I  QI  D+ E+ QR++   ++            N+   ++        RL  R P G      F   E   +VR +V N +      R+ F +   +PRR   T D+  TL +L LVP+A
Sbjct:  343 RQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASNVITTDASVSSVDETRLQIRLPGGIQRTKSFPAGEVLATVRVYVRNEMLAASDVRD-FTLATSYPRREFQTEDEVKTLNELNLVPNA 472
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Fly
Match: CG8209 (gene:FBgn0035830 transcript:FBtr0076753)

HSP 1 Score: 49.6766 bits (117), Expect = 3.679e-6
Identity = 42/141 (29.79%), Postives = 59/141 (41.84%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDNGESGGV----------RLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            ++EEK ARD++  QIE DK  RK R   +Q    N +          +    GV          R+  R  DGS++   F   E   +VR F    I+   G    F +   FPR+     D +  L  L LVPSA   ++
Sbjct:  194 KDEEKAARDRVKAQIEADKAARKAR---EQKELGNAEPAPSVSSTTVSSPPAGVKSPPRDYTETRIQVRLQDGSTLQETFNVKEQLSAVRVF----IQMKTGIESPFSLMTTFPRKLFAEDDYEKPLEVLGLVPSAVITMT 327
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Xenopus
Match: fbxw9 (F-box and WD repeat domain containing 9 [Source:Xenbase;Acc:XB-GENE-5726702])

HSP 1 Score: 81.6481 bits (200), Expect = 6.067e-16
Identity = 71/264 (26.89%), Postives = 115/264 (43.56%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLA---------KPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKF---RRVPSYPPTRVPDIVPPSTGASGSAITS-QWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + EEK ARD+I +QI  D+ +R  R++  +           +  + + E +        S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D   +L+ L+L PSAS  +    +P N+   S+    W  L  + F  + +W      LS F      PS P  R       ST  + S+ +  + +  ++R+L   +    K+G +   +    + +++     WNGNSTQQM
Sbjct:  216 KAEEKAARDRIRQQIAQDRADRAARFAKNKEELEAAKAAELQAQQAEREARREVAQKERSTIARIQFRLPDGSSFTNQFASEAPLEEARQFAAQTVGNTYGN---FALATMFPRREFTKEDYGKSLLSLELAPSASIVLLPAGRPSNAVIQSSEGGVWGFLGTVLFPLLAVWRF----LSNFLFGSPSPSQPAERPAHPRHESTNPTASSSSEPKRDVVRKRVLEKRTDEFKKEGKIYRLRTQDDEDENNT----WNGNSTQQM 468
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Xenopus
Match: fbxw9 (F-box and WD repeat domain containing 9 [Source:Xenbase;Acc:XB-GENE-5726702])

HSP 1 Score: 77.7962 bits (190), Expect = 1.554e-14
Identity = 71/264 (26.89%), Postives = 113/264 (42.80%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLA---------KPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKF---RRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQR-RLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + EEK ARD+I +QI  D+ +R  R++  +           +  + + E +        S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D   +L+ L+L PSAS  +    +P N+   S+    W  L  + F  + +W      LS F      PS P  R       ST  + S+ +    +  R R+L   +    K+G +   +    + +++     WNGNSTQQ+
Sbjct:  327 KAEEKAARDRIRQQIAQDRADRAARFAKNKEELEAAKAAELQAQQAEREARREVAQKERSTIARIQFRLPDGSSFTNQFASEAPLEEARQFAAQTVGNTYGN---FALATMFPRREFTKEDYGKSLLSLELAPSASIVLLPAGRPSNAVIQSSEGGVWGFLGTVLFPLLAVWRF----LSNFLFGSPSPSQPAERPAHPRHESTNPTASSSSEPKRDVVRKRVLEKRTDEFKKEGKIYRLRTQDDEDENNT----WNGNSTQQI 579
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Xenopus
Match: ubxn1 (UBX domain protein 1 [Source:NCBI gene;Acc:448372])

HSP 1 Score: 48.9062 bits (115), Expect = 9.738e-6
Identity = 40/142 (28.17%), Postives = 62/142 (43.66%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRY---SNQQLAKPNEDKMELK--------HRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            + EEK ARD++  +I  DK ER +R+    ++ ++ P E  +                  E    R+  R  DGS+++  F   E   +VR +V   +    G    F +   FPRR     D +  L +L LVPSA   V+
Sbjct:  146 KQEEKLARDRVREKIARDKAERARRFGGAGSEPISPPAEASIPATTPSPSSPVQEPPTKKEYDQCRIQVRLLDGSALSQTFRAREQLAAVRLYV--ELNWPGGAPGPFNLLTSFPRRVFTEEDMEKPLQELGLVPSAVLIVA 285
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Mouse
Match: Ubxn4 (UBX domain protein 4 [Source:MGI Symbol;Acc:MGI:1915062])

HSP 1 Score: 82.8037 bits (203), Expect = 1.873e-16
Identity = 78/262 (29.77%), Postives = 122/262 (46.56%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPN--------EDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQ---RRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++  + A+          +   E+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    +S F  + S PP         ST  S SA +S+ E+R+   +R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  257 KAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLTKQAGTEVKRESTARDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATSIVHSSSGDIWTLLGTVLYPFLAIWRL----ISNF--LFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRMLEKRGEDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 506
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Mouse
Match: Ubxn1 (UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:1289301])

HSP 1 Score: 50.8322 bits (120), Expect = 1.525e-6
Identity = 38/133 (28.57%), Postives = 56/133 (42.11%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRY-------SNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGC-RELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            AR ++  +IE DK ER ++Y       S+     P               E    R+  R PDG+S+   F   E   +VR +V  H     G  ++  ++   FPRR     D +  L +L LVPSA   V+
Sbjct:  125 ARQRVREKIERDKAERAKKYGGSVGSRSSPPATDPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVA 257
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Mouse
Match: Ubxn1 (UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:1289301])

HSP 1 Score: 50.8322 bits (120), Expect = 1.845e-6
Identity = 38/133 (28.57%), Postives = 56/133 (42.11%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRY-------SNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGC-RELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            AR ++  +IE DK ER ++Y       S+     P               E    R+  R PDG+S+   F   E   +VR +V  H     G  ++  ++   FPRR     D +  L +L LVPSA   V+
Sbjct:  160 ARQRVREKIERDKAERAKKYGGSVGSRSSPPATDPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVA 292
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Mouse
Match: Ubxn1 (UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:1289301])

HSP 1 Score: 50.8322 bits (120), Expect = 1.845e-6
Identity = 38/133 (28.57%), Postives = 56/133 (42.11%), Query Frame = 3 
Query:  660 ARDKILRQIEDDKMERKQRY-------SNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGC-RELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVS 1034
            AR ++  +IE DK ER ++Y       S+     P               E    R+  R PDG+S+   F   E   +VR +V  H     G  ++  ++   FPRR     D +  L +L LVPSA   V+
Sbjct:  160 ARQRVREKIERDKAERAKKYGGSVGSRSSPPATDPGPVPSSPSQEPPTKREYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVELHRGEEPGQDQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVA 292
[Close]
BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q5R4I3|UBXN4_PONAB (UBX domain-containing protein 4 OS=Pongo abelii OX=9601 GN=UBXN4 PE=2 SV=1)

HSP 1 Score: 90.1225 bits (222), Expect = 5.810e-18
Identity = 76/264 (28.79%), Postives = 118/264 (44.70%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSN---------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPT----RVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++                 + +ME+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  V    +P  S   S++ + WT L  + +  + IW +    L       + PPT    RV    PP+  +S    + + E  ++R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  258 KAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVVLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFL-----FSNPPPTQTSVRVTSSEPPNPASSSK--SEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 508
[Close]
BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q3ZBU9|UBXN4_BOVIN (UBX domain-containing protein 4 OS=Bos taurus OX=9913 GN=UBXN4 PE=2 SV=2)

HSP 1 Score: 89.7373 bits (221), Expect = 7.751e-18
Identity = 76/263 (28.90%), Postives = 118/263 (44.87%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSN---------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQ---RRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++                 + +ME+K        S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    +S F  + S PP     +   S   S  A +S  E+R+   +R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  258 KAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEIKRETSTKERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTTSMVHSSSGDFWTLLGTVLYPFLAIWRL----ISNF--LFSNPPPAQTSVRAASLETSNLASSSNSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 508
[Close]
BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q92575|UBXN4_HUMAN (UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2)

HSP 1 Score: 88.9669 bits (219), Expect = 1.550e-17
Identity = 75/264 (28.41%), Postives = 118/264 (44.70%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSN---------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPT----RVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++                 + +ME+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    L       + PPT    RV    PP+  +S    + + E  ++R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  258 KAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFL-----FSNPPPTQTSVRVTSSEPPNPASSSK--SEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 508
[Close]
BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q8VCH8|UBXN4_MOUSE (UBX domain-containing protein 4 OS=Mus musculus OX=10090 GN=Ubxn4 PE=1 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.276e-15
Identity = 78/262 (29.77%), Postives = 122/262 (46.56%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPN--------EDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQ---RRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++  + A+          +   E+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    +S F  + S PP         ST  S SA +S+ E+R+   +R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  257 KAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLTKQAGTEVKRESTARDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATSIVHSSSGDIWTLLGTVLYPFLAIWRL----ISNF--LFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRMLEKRGEDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 506
[Close]
BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Match: sp|Q5HZY0|UBXN4_RAT (UBX domain-containing protein 4 OS=Rattus norvegicus OX=10116 GN=Ubxn4 PE=1 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 2.874e-15
Identity = 78/262 (29.77%), Postives = 122/262 (46.56%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKM--------ELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQ---RRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  R++  + A+  +           E+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    +S F  + S PP         ST  S SA +S+ E+R+   +R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  257 KAEDRAARERIKQQIALDRAERAARFAKTKEAEAAKAAALLAKQAEAEVKRESSTRDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTREDYKRKLLDLELAPSASVVLLPAGRPATSIVPSSSGDIWTLLGTVLYPFLAIWRL----ISNF--LFSNPPPAQTSARATSTEPSNSASSSKSEKREPVRKRVLEKRGEDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 506
[Close]
BLAST of UBX domain-containing protein 4 vs. TrEMBL
Match: A0A3B3SJQ7 (UBX domain protein 4 OS=Paramormyrops kingsleyae OX=1676925 GN=UBXN4 PE=4 SV=1)

HSP 1 Score: 103.219 bits (256), Expect = 9.333e-20
Identity = 80/264 (30.30%), Postives = 121/264 (45.83%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQ---------QLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVP----PSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + EE+ ARD++ +QI  D++ER  RY+              +  + + E +   +    S   R+ FR PDGSS  ++F         REF A  + N  G    F +   FPRR     D   TL++L+LVPSAS  +  + +P N+   S+A   W+ L  I +  + +W      +S F      PP     + P    PST +SG A   + E  ++R+L   +    KDG +   +      DD+     WNGNSTQQM
Sbjct:  276 KAEERAARDRVRQQIALDRVERAARYAKSTEEAEAAKVAALQAAKAEQEARKEALQKERSAVARIQFRLPDGSSFTNQFPSETRLREAREFAAQEVGNRYGN---FSLATMFPRREFTQEDLDQTLLELELVPSASVVLLPVGRPANTMVPSSAGGFWSVLGTIFYPLLAVWRF----ISSFLFTTPPPPGSASSVPPQRPGPSTVSSGEA---KREPIRKRVLEKRADDFKKDGKIYRLRTQEDSEDDNNT---WNGNSTQQM 526
[Close]
BLAST of UBX domain-containing protein 4 vs. TrEMBL
Match: T2M8H8 (UBX domain-containing protein 4 OS=Hydra vulgaris OX=6087 GN=UBXN4 PE=2 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 2.460e-17
Identity = 77/251 (30.68%), Postives = 123/251 (49.00%), Query Frame = 3 
Query:  648 EEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKH---RNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAI-TSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            EEK AR+K+  Q+  DK+E+  R+  ++ ++ NE   E K      +   ES   R+ FR PDGSS++++F     F S+ +F+  H+R +        +   FP+    T+D + +L +L LVP+AS  VS    P     +ST  +  ++ I FI   + S++ WVLS F    S  P+ V      S    G  + TS +           ++ I K  N +  +   +  +DD++   WNGNSTQQM
Sbjct:  235 EEKAAREKLREQLRLDKIEKNARFEMEKKSR-NEALTEKKQAVASPVLKAESNSTRIQFRLPDGSSLSNQFPADAMFLSLHDFICKHMRESN-----LRLTTLFPKYEFTTSDMEKSLRELSLVPNASIIVS----PGKPQVVSTPQSLPISIIIFIFYPLISLYYWVLSFFSTTTSQQPSIV------SQNDEGDKLDTSHYN---------SNKNIRKRNNQSNIRQLQRDENDDDENNTWNGNSTQQM 460
[Close]
BLAST of UBX domain-containing protein 4 vs. TrEMBL
Match: A0A2U9C7U0 (Putative UBX domain-containing protein 4 OS=Scophthalmus maximus OX=52904 GN=SMAX5B_021654 PE=4 SV=1)

HSP 1 Score: 93.9745 bits (232), Expect = 9.721e-17
Identity = 75/264 (28.41%), Postives = 117/264 (44.32%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDN---------GESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFA-VSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQ---RRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + EEK AR+++  QI  D+ +R  RY+  Q+ + +  +  L+ R  +            S   R+ FR PDGSS  ++F    T    R F    + N  G    F +   FPRR   + D   TL++L+L PSAS   + +  +P NS   S+    W  L  I +  + +W      L      P  P +R P   P S   + S  +S  ++R+   +  L  + +   K+G V   +      D++     WNGNSTQQM
Sbjct:  245 KTEEKAARERVKLQIALDRADRAARYAKTQVEERSSKEALLQARQAEQEARKEALVRQRSTIARIQFRLPDGSSFTNQFPAQSTLQEARHFAVQEVGNRYGN---FSLATMFPRREFTSEDLNKTLLELELAPSASIVLLPYSGRPANSMVQSSGGGVWAVLGTILYPLLAVWRFLSTFLFTAPPPPG-PASRGP--APQSGSYTNSTPSSDKDKRETPSKHTLEKQPKEFKKEGKVCSLRTQEDSEDENNT---WNGNSTQQM 499
[Close]
BLAST of UBX domain-containing protein 4 vs. TrEMBL
Match: F6ST58 (UBX domain protein 4 OS=Callithrix jacchus OX=9483 GN=UBXN4 PE=2 SV=2)

HSP 1 Score: 93.9745 bits (232), Expect = 1.086e-16
Identity = 75/260 (28.85%), Postives = 119/260 (45.77%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQQ---------LAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            + E++ AR++I +QI  D+ ER  RY+  +              + +ME+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    L      P+    RV    PP+  A+ S+ + + E  ++R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:  258 KAEDRAARERIKQQIALDRAERAARYAKTKEEVEAAKAAALLAKQTEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSRDIWTLLGTVLYPFLAIWRLISNFLFS-NPPPAQTSVRVTSSEPPN--AASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 508
[Close]
BLAST of UBX domain-containing protein 4 vs. TrEMBL
Match: B3KTD5 (cDNA FLJ38083 fis, clone CTONG2016408, highly similar to UBX domain-containing protein 2 OS=Homo sapiens OX=9606 PE=2 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 2.519e-16
Identity = 75/262 (28.63%), Postives = 117/262 (44.66%), Query Frame = 3 
Query:  648 EEKEARDKILRQIEDDKMERKQRYSN---------QQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN-WT-LAPINFICITIWSIFEWVLSKFRRVPSYPPT----RVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            E++ AR++I +QI  D+ ER  R++                 + +ME+K  +     S   R+ FR PDGSS  ++F         R+F A  + N  G    F +   FPRR     D K  L+DL+L PSAS  +    +P  S   S++ + WT L  + +  + IW +    L       + PPT    RV    PP+  +S    + + E  ++R+L        K+G +   +      D++     WNGNSTQQM
Sbjct:   26 EDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGN---FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFL-----FSNPPPTQTSVRVTSSEPPNPASSSK--SEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNT---WNGNSTQQM 274
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Sea Lamprey
Match: UBXN4 (UBX domain protein 4 [Source:HGNC Symbol;Acc:HGNC:14860])

HSP 1 Score: 63.5438 bits (153), Expect = 4.124e-11
Identity = 45/158 (28.48%), Postives = 69/158 (43.67%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQRYSNQ-----------QLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMN 1082
            + EE+ A+++I +QI  D+ ER  RY+ +           Q AK  E +   K +      +   R+ +R PDGS   ++F    T    R F    ++N  G    F +   FPRR     D   TL +L L PSA+  V    +P   S   T ++
Sbjct:  254 KAEERAAKERIRQQIAQDRAERAARYNREKEEVDAARVAAQQAKEAEKRA--KEQQTQQDRTAIARIQYRLPDGSYFTNQFSSETTLAEARTFAQQVVKNAYG---DFTLATAFPRRNFTVDDYPRTLQELGLAPSAAIIV-LPVRPRTPSGARTRLH 405
[Close]
BLAST of UBX domain-containing protein 4 vs. Ensembl Nematostella
Match: EDO42505 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1H1])

HSP 1 Score: 78.1814 bits (191), Expect = 1.650e-15
Identity = 72/264 (27.27%), Postives = 109/264 (41.29%), Query Frame = 3 
Query:  642 RNEEKEARDKILRQIEDDKMERKQR----YSNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTA-----------MNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            R +E+ AR+ + +QI  DK ER+ +       +Q A+               G    VRL FR PDGS + H F       +  ++V +H  + +       +   +PRR     D + +L DL L PSA+  V+ I K + SS I+ +             W LAP  FI     +IF ++ +     P+     +      +     S  T + E R RR  +        DGN+   ++     DD      WNGNSTQQM
Sbjct:  234 RAKERAAREAVRQQIARDKAEREAQKQAELKERQQAQDTSASTTAASTYTGGGSYSNVRLQFRLPDGSGITHLFPADALLSTAHQYVVSHTGSRLPS---VAMSTTYPRRQFTDDDMQRSLTDLGLAPSATIIVTEIFKHVGSSVITLSASSSEVDSAGLFGWLLAP--FI-----AIFTFISAFLFGSPAMQRGSIIGGGGRALSLISSCFTLRTEVR-RRATSPRGSNQSSDGNIHRLQNFRDDEDDQNT---WNGNSTQQM 483
[Close]
BLAST of UBX domain-containing protein 4 vs. Planmine SMEST
Match: SMESG000047328.1 (SMESG000047328.1)

HSP 1 Score: 716.072 bits (1847), Expect = 0.000e+0
Identity = 453/454 (99.78%), Postives = 453/454 (99.78%), Query Frame = 3 
Query:   27 MLWHKGDVYDAVSKVKESQKYLFVFIRDENTSQDCIEILEKSSKLQDILFNSICLNLMKDTDEYHKFSEVYRVEEIPSIHIITYQGXXXXXXXXXXXXXXLCVKLKKIYGXXXXXXXXXXXXXXXXXXXXAGLVDEVEDAESKEAKMIEVRRLLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXHXXXXXXXXXXXXXXXXXXXXXRNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFXXXXXXXXXXXXXARWNGNSTQQM 1388
            MLWHKGDVYDAVSKVKESQKYLFVFIRDENTSQDCIEILEKSSKLQDILFNSICLNLMKDTDEYHKFSEVYRVEEIPSIHIITYQGEIIEVIKNIENEENLCVKLKKIYGVKSEESVSEISSE HVLSDSAGLVDEVEDAESKEAKMIEVRRLLAEKHRQKAEEEKQKEKEEELKRRELGKQLHQLKQTQKEREEEEAKAQIKKQRNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFKDSSKKIDDDEDEARWNGNSTQQM
Sbjct:    1 MLWHKGDVYDAVSKVKESQKYLFVFIRDENTSQDCIEILEKSSKLQDILFNSICLNLMKDTDEYHKFSEVYRVEEIPSIHIITYQGEIIEVIKNIENEENLCVKLKKIYGVKSEESVSEISSEFHVLSDSAGLVDEVEDAESKEAKMIEVRRLLAEKHRQKAEEEKQKEKEEELKRRELGKQLHQLKQTQKEREEEEAKAQIKKQRNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRNIDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRELFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTAMNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGSAITSQWEERQRRLLAAESRTIMKDGNVAGFKDSSKKIDDDEDEARWNGNSTQQM 454
The following BLAST results are available for this feature:
BLAST of UBX domain-containing protein 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
UBXN43.227e-1828.41UBX domain protein 4 [Source:HGNC Symbol;Acc:HGNC:... [more]
UBXN19.924e-727.14UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
UBXN11.369e-627.14UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
UBXN13.042e-627.41UBX domain protein 1 [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ubxn-46.781e-726.56UBX domain-containing protein 4 [Source:UniProtKB... [more]
ubxn-46.781e-726.56UBX domain-containing protein 4 [Source:UniProtKB... [more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG80424.613e-829.01gene:FBgn0027554 transcript:FBtr0076766[more]
CG82093.679e-629.79gene:FBgn0035830 transcript:FBtr0076753[more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UBX domain-containing protein 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
fbxw96.067e-1626.89F-box and WD repeat domain containing 9 [Source:Xe... [more]
fbxw91.554e-1426.89F-box and WD repeat domain containing 9 [Source:Xe... [more]
ubxn19.738e-628.17UBX domain protein 1 [Source:NCBI gene;Acc:448372][more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Ubxn41.873e-1629.77UBX domain protein 4 [Source:MGI Symbol;Acc:MGI:19... [more]
Ubxn11.525e-628.57UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:12... [more]
Ubxn11.845e-628.57UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:12... [more]
Ubxn11.845e-628.57UBX domain protein 1 [Source:MGI Symbol;Acc:MGI:12... [more]
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BLAST of UBX domain-containing protein 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5R4I3|UBXN4_PONAB5.810e-1828.79UBX domain-containing protein 4 OS=Pongo abelii OX... [more]
sp|Q3ZBU9|UBXN4_BOVIN7.751e-1828.90UBX domain-containing protein 4 OS=Bos taurus OX=9... [more]
sp|Q92575|UBXN4_HUMAN1.550e-1728.41UBX domain-containing protein 4 OS=Homo sapiens OX... [more]
sp|Q8VCH8|UBXN4_MOUSE1.276e-1529.77UBX domain-containing protein 4 OS=Mus musculus OX... [more]
sp|Q5HZY0|UBXN4_RAT2.874e-1529.77UBX domain-containing protein 4 OS=Rattus norvegic... [more]
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BLAST of UBX domain-containing protein 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3B3SJQ79.333e-2030.30UBX domain protein 4 OS=Paramormyrops kingsleyae O... [more]
T2M8H82.460e-1730.68UBX domain-containing protein 4 OS=Hydra vulgaris ... [more]
A0A2U9C7U09.721e-1728.41Putative UBX domain-containing protein 4 OS=Scopht... [more]
F6ST581.086e-1628.85UBX domain protein 4 OS=Callithrix jacchus OX=9483... [more]
B3KTD52.519e-1628.63cDNA FLJ38083 fis, clone CTONG2016408, highly simi... [more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UBX domain-containing protein 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
UBXN44.124e-1128.48UBX domain protein 4 [Source:HGNC Symbol;Acc:HGNC:... [more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UBX domain-containing protein 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO425051.650e-1527.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of UBX domain-containing protein 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of UBX domain-containing protein 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000047328.10.000e+099.78SMESG000047328.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021790 ID=SMED30021790|Name=UBX domain-containing protein 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1471bp
TTACAATTGATTTGCTTTTTTGAAATATGCTGTGGCATAAAGGTGATGTG
TATGATGCAGTTAGTAAAGTGAAAGAATCCCAAAAATATTTATTTGTATT
TATCAGAGATGAAAATACTTCCCAAGATTGTATTGAGATTTTAGAAAAGT
CTTCTAAGCTGCAGGACATTTTATTCAACTCAATATGTTTGAATTTAATG
AAGGATACAGATGAATATCATAAATTTAGTGAAGTTTACAGAGTAGAAGA
AATTCCGTCAATTCATATTATAACTTATCAAGGAGAAATCATTGAGGTTA
TTAAAAATATTGAAAACGAAGAAAATTTATGTGTAAAACTGAAAAAAATT
TATGGAGTCAAAAGTGAAGAATCAGTTTCAGAGATTTCATCAGAGTCCCA
TGTGTTGTCTGATTCTGCTGGACTCGTTGATGAAGTTGAAGATGCGGAAA
GTAAAGAAGCTAAAATGATTGAAGTGAGACGACTTTTAGCTGAAAAACAT
AGACAAAAAGCTGAGGAAGAGAAACAAAAAGAAAAGGAAGAAGAATTGAA
ACGAAGAGAACTTGGCAAACAACTTCATCAACTGAAACAAACACAAAAAG
AAAGAGAAGAGGAAGAAGCTAAAGCTCAAATAAAGAAACAAAGAAATGAA
GAAAAAGAGGCTCGAGATAAAATTCTTCGTCAGATTGAGGATGATAAAAT
GGAAAGAAAGCAAAGGTATTCCAATCAGCAATTAGCGAAGCCAAATGAAG
ACAAAATGGAATTAAAACACCGCAATATTGATAACGGTGAATCCGGCGGA
GTTCGATTGCTTTTTAGATTTCCAGATGGGTCGTCAGTAAATCACAAGTT
CGAATGTAGCGAAACGTTTCATTCCGTCCGTGAGTTTGTAGCCAATCATA
TCCGGAATAATATGGGATGTCGAGAACTGTTTGAAATCAAGCAGTTTTTC
CCCAGAAGAACAATTTTGACTACTGATGATAAAATGACATTGGTAGATTT
GCAGCTGGTTCCCAGTGCATCGTTCGCTGTTTCATTCATTACCAAACCAA
TAAATTCGAGTTCGATTTCTACCGCTATGAATTGGACACTGGCACCAATT
AATTTTATATGCATAACCATATGGTCAATATTTGAATGGGTGTTATCAAA
ATTTAGGAGAGTTCCTTCATATCCTCCCACTAGAGTGCCGGATATTGTCC
CACCTAGTACAGGTGCTAGTGGAAGCGCGATTACGTCACAGTGGGAAGAA
CGACAAAGACGACTGCTGGCAGCTGAAAGCAGAACCATTATGAAAGATGG
GAATGTCGCGGGATTTAAGGATTCATCTAAGAAAATAGACGACGATGAAG
ATGAAGCGAGGTGGAATGGAAATTCTACCCAACAAATGTAACTCGAGAGA
TACCCATTTTCATTTGAGCAATTGTGTCATAATTTTGTTTTAATTATACT
ACGCGTATTTTTCAAAAAAAA
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protein sequence of SMED30021790-orf-1

>SMED30021790-orf-1 ID=SMED30021790-orf-1|Name=SMED30021790-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=455bp
MLWHKGDVYDAVSKVKESQKYLFVFIRDENTSQDCIEILEKSSKLQDILF
NSICLNLMKDTDEYHKFSEVYRVEEIPSIHIITYQGEIIEVIKNIENEEN
LCVKLKKIYGVKSEESVSEISSESHVLSDSAGLVDEVEDAESKEAKMIEV
RRLLAEKHRQKAEEEKQKEKEEELKRRELGKQLHQLKQTQKEREEEEAKA
QIKKQRNEEKEARDKILRQIEDDKMERKQRYSNQQLAKPNEDKMELKHRN
IDNGESGGVRLLFRFPDGSSVNHKFECSETFHSVREFVANHIRNNMGCRE
LFEIKQFFPRRTILTTDDKMTLVDLQLVPSASFAVSFITKPINSSSISTA
MNWTLAPINFICITIWSIFEWVLSKFRRVPSYPPTRVPDIVPPSTGASGS
AITSQWEERQRRLLAAESRTIMKDGNVAGFKDSSKKIDDDEDEARWNGNS
TQQM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003676nucleic acid binding
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0005634nucleus
GO:0005635nuclear envelope
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0002032epidermal cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036249Thioredoxin-like_sf
IPR001012UBX_dom
IPR012336Thioredoxin-like_fold
IPR029071Ubiquitin-like_domsf
Vocabulary: biological process
TermDefinition
GO:0006986response to unfolded protein
GO:0030433ubiquitin-dependent ERAD pathway
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 147..222
NoneNo IPR availableGENE3DG3DSA:3.10.20.90coord: 249..336
e-value: 1.2E-15
score: 59.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 432..446
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 432..454
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 159..214
NoneNo IPR availablePANTHERPTHR46424FAMILY NOT NAMEDcoord: 1..454
NoneNo IPR availableCDDcd16117UBX_UBXN4coord: 260..335
e-value: 4.79206E-18
score: 76.2148
IPR001012UBX domainSMARTSM00166ubx_3coord: 251..337
e-value: 1.2E-7
score: 41.4
IPR001012UBX domainPFAMPF00789UBXcoord: 259..332
e-value: 2.4E-12
score: 46.9
IPR001012UBX domainPROSITEPS50033UBXcoord: 254..335
score: 18.389
IPR036249Thioredoxin-like superfamilyGENE3DG3DSA:3.40.30.10coord: 5..111
e-value: 4.8E-6
score: 28.6
IPR036249Thioredoxin-like superfamilySUPERFAMILYSSF52833Thioredoxin-likecoord: 3..109
IPR029071Ubiquitin-like domain superfamilySUPERFAMILYSSF54236Ubiquitin-likecoord: 206..335