Nicotinic acetylcholine receptor alpha 6 subunit

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   52 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 522          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVD+K Q++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDQKRQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVD+K Q++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDQKRQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  229 EKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPD---SICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTH-NIY---QDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            E+RL + L        +N LERPV N S PV V     L QIIDVDEKNQ++  + WL   WNDY+  W+ +EYG IT +      +W PDVLLYNS D NF++     +++   G + +VPPG+FK +C +D+ WFPFD Q C  KFG+W+YDG  ++L+                G  ++  Y  +GEW L  + + R  + Y CC   + DV   + + RR  YY FN ++PCI+ + + LL F LP DAGEKI+L +T++LS+  F  ++++  P +S ++PLL ++F   M++ T S +FTV VLN H+     H +  + R ++  W+  +L +  P    +  ++ +  S KP    +  I N K +   L+      +D   N Y   Q +     SL    +++  + NG   +V     L  LH    ++  +L+ +T ++ E D+E      WKFAA V+DR C+ +FT+     T GIF+SA
Sbjct:   23 ERRLYEDLMR-----NYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVYVNAWLDYTWNDYNLVWDKAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSTGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLDLQ-------------PATGGFDISEYISNGEWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIPWILRMKRPGHNLTYASLPSLFSTKPNRHSESLIRNIKDNEHSLSRANSFDADCRLNQYIMTQSVSNGLTSLGSIPSTMISS-NGTTTDVSQQATLLILH----RIYHELKIVTKRMIEGDKEEQACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFWSA 493          

Query:  199 FFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDHK----VPRFIRVIINQWLAKVLFITPPDSI---------CTISTKASKKPPVIIDKTIYN--SKVSHSLLANVLELSSDTHNIYQDLFK-----KRKSLS----------EFETSVDDAVNG-DCQNVE---DSGMLCSLHED---------------------------LKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
             FR +  G +E+RL   L      + +N L RPV+NES  V VL G    QI+D+DEK+QI+ +++WL + W D++  W+PSE+G I  + +  N +W PDVLLYNS D  F++   V  V+ Y G+++++PP + +S+C +D+ +FPFD Q+CT+KFG+W+Y G   +L                   +    Y  +GEWEL+    +R++  Y CC   + DV  T+ I RR  YY FN +LPC++IS++ALL F LP+D GEK++LGVTI +SL +F +++A+ MPQ+S +LPL+ +YF  +M     S++ TVI LN HH   +    + +F++ ++  WL  +L +  PD +          + + K  ++  + +++ I    +   HS +   + L   T N + D  K     KR S S          +   ++D ++N   C  V    ++G     H+                               +  +L  I+ ++++ +       +W FA+ V+DR C + F+   F  T  I ++A
Sbjct:   15 LFRVIWTGDHERRLYAKL-----AENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDPSEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAYFPFDTQHCTMKFGSWTYSGFFTDL---------------INTTISPATYKPNGEWELLGLTSQRSIFFYECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVFMIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWLPTLLGMERPDVLELSVHGAHYASDNKKKQRQYLIEVERHILTRPNGNGHSAVDKAVHLDLSTGNPHSDAKKSSPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTRPLENGSATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFHHILNELRVISARVRKEEAMHALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNA 549          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDHK----VPRFIRVIINQWLAKVLFITPPDSI---------CTISTKASKKPPVIIDKTIYN--SKVSHSLLANVLELSSDTHNIYQDLFK-----KRKSLS----------EFETSVDDAVNG-DCQNVE---DSGMLCSLHED---------------------------LKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            G +E+RL   L      + +N L RPV+NES  V VL G    QI+D+DEK+QI+ +++WL + W D++  W+PSE+G I  + +  N +W PDVLLYNS D  F++   V  V+ Y G+++++PP + +S+C +D+ +FPFD Q+CT+KFG+W+Y G   +L                   +    Y  +GEWEL+    +R++  Y CC   + DV  T+ I RR  YY FN +LPC++IS++ALL F LP+D GEK++LGVTI +SL +F +++A+ MPQ+S +LPL+ +YF  +M     S++ TVI LN HH   +    + +F++ ++  WL  +L +  PD +          + + K  ++  + +++ I    +   HS +   + L   T N + D  K     KR S S          +   ++D ++N   C  V    ++G     H+                               +  +L  I+ ++++ +       +W FA+ V+DR C + F+   F  T  I ++A
Sbjct:   28 GDHERRLYAKL-----AENYNKLARPVRNESEAVVVLLGMDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDPSEFGNIKEVRLPINNIWKPDVLLYNSVDQQFDSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAYFPFDTQHCTMKFGSWTYSGFFTDL---------------INTTISPATYKPNGEWELLGLTSQRSIFFYECCPEPYYDVTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPADCGEKLNLGVTIFMSLCVFMIMVAEAMPQTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKPMNKFLKTLLLGWLPTLLGMERPDVLELSVHGAHYASDNKKKQRQYLIEVERHILTRPNGNGHSAVDKAVHLDLSTGNPHSDAKKSSPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTRPLENGSATINHKSSPQINPINNNNIYKCANNQKTQFEDRHFHHILNELRVISARVRKEEAMHALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNA 555          

Query:  268 VDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPP-------------DS-------------------ICTISTKASKKPP------VIIDKTIYNSKVSHSLLANVLELSSDTHNIYQD---LFKKRKSLSEFETSVD----DAVN--GDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFS 1677
            ++ + PLERP++N S  V V  G  L QI+DVDEKNQ++  + WL   W DY   W P +YGG+T +      +W PDVL+YNSAD  F++  +  +++  +G ++++PPGL++ +C + V WFPFDVQ C LKFG+W++DG  +NL+I                  ++  Y ++GEW L  + ++R +Q Y CC   + D+  T VI RR  YY FN +LPCI+I+ + L+ F  P DAGEK+SL +TIMLS+ +FQ  +A+  P +S ++P L+ +F   +      +  T + LN HH     H++    R+++ +W+  +L +  P             DS                   I  I+ +++K  P       I+D+   + +    L  + +    D      D    ++   + S+   S      +A N  G+   VE    L  L    ++V   L  I   I+E ++      +WKF+A V+DR C++IFT   F  T  +F S
Sbjct:   34 LEDYEPLERPIENSSEAVMVKMGLVLQQIVDVDEKNQVVDVNAWLKFSWVDYSLKWKPEDYGGVTDLRFRKGQLWTPDVLMYNSADPQFDSRYASNLLVYPNGLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLEID-------------DNGFDISNYMQNGEWTLEGTTVKRNIQYYQCCPEPYYDLVFTFVIRRRALYYAFNLILPCILITMLTLVGFTFPPDAGEKMSLQITIMLSICIFQNYVAELSPPTSEAVPFLSAFFAVCLFTCACCVTATTLALNFHHRTGKSHQMNNTFRLLMLEWIPWLLMMRRPGYVARCGKIVKQDDSEDEFEERQTRLDQQRIATIISQITVESNKPTPTFPRRVTIVDEVNSDGEAEEPLPPDEVIREEDDDVASMDDPPAWRSTTTTSQPPQSPAHLWWNATNRMGNRVPVEQIAQLLVL----QQVHGHLSEINKHIREREKSKKIEDDWKFSALVVDRICMVIFTSFLFGSTVALFAS 536          

Query:  184 LSVILFFRDVNAGSY-EKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNT---VWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHH---NDHKVPRFIRVIINQWLAKVLFITPPD------SICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLK-EWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            LS+++   ++  GS  E +L   L     +  +NPLERPV+N S P+EV     L QI+DVDEKNQI+  + WLS  W D+   W P +YGGI  I   P +   +W PDVLLYNSA  +F++     ++  + G++ ++PPG+ K  C +DVTWFPFD Q C +KFG+W++ G  ++L+I +    + +         ++  Y  +GEW++IS++ +R V  Y CC   +  V   + I RR  YY FN ++P ++IS +A+L F+ P DAGEKI+L VTI+L++  F  ++++  P +S ++PL+ ++F   M++ + S++FT++VLN H    + H++   +R ++ ++L  +LF++ P       ++   + K  KKP   +D  + ++   +   A +L                                          +L S+H +L++V              +E  ++++ +W+FAA V+DR C+++FT+        I  SA
Sbjct:   10 LSLVIIHSNLCDGSVAETKLFTDL-----LKGYNPLERPVQNSSQPLEVKIKLFLQQILDVDEKNQIVSVNAWLSYTWFDHKLQWEPKKYGGIQDIR-FPGSSDHIWKPDVLLYNSAAEDFDSTFKSNLLTYHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGTQSM--------DLSTYLVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLMAILGFMFPPDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNLHFRSADSHEMNPLVRRVLLEFLPWLLFMSRPGYKFVKANVIDSTDKMPKKPKNPLDCNLPSNHAGYE--AQIL------------------------------------------LLHSVHTELRRV--------VAFYNKEEHDERIQTDWRFAAMVVDRACLLLFTVFIVISILAIMMSA 456          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVN-GDCQNVED--SGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            ++FL++I   ++   G +EKRLL HL +      +N LERPV NES P+EV FG TL QIIDVDEKNQ++ T++WLS+ WNDY+  WN +EYGG+  + + PN +W PDVL+YNSAD  F+      +V+ ++GS  YVPPG+FKSTC +D+TWFPFD Q+C +KFG+W+YDG  ++L +             +    ++  +  +GEW L++   ++    YACC   ++D+  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A+ +PQ S ++PLL  YF  +M +   S++ TV+VLN HH     H++P +I+ +  QWL  +L +  P        K ++K  ++ ++        + S SLLANVL++  D           R ++S  +T++  + + G    VE+  + + C+ H+DL  + K+L+FIT ++++ D+E + + +WKFAA V+DRFC+I+FTL     T  +  SA
Sbjct:   15 LIFLAII---KESCQGPHEKRLLNHLLS-----TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN------------SEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF----------RHTISGSQTAIGSSASFGRPTTVEEHHTAIGCN-HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 488          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVN-GDCQNVED--SGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            ++FL++I   ++   G +EKRLL HL +      +N LERPV NES P+EV FG TL QIIDVDEKNQ++ T++WLS+ WNDY+  WN +EYGG+  + + PN +W PDVL+YNSAD  F+      +V+ ++GS  YVPPG+FKSTC +D+TWFPFD Q+C +KFG+W+YDG  ++L +             +    ++  +  +GEW L++   ++    YACC   ++D+  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A++MP +S ++PL+  YF  +M +   S++ TV+VLN HH     H++P +I+ +  QWL  +L +  P        K ++K  ++ ++        + S SLLANVL++  D           R ++S  +T++  + + G    VE+  + + C+ H+DL  + K+L+FIT ++++ D+E + + +WKFAA V+DRFC+I+FTL     T  +  SA
Sbjct:   15 LIFLAII---KESCQGPHEKRLLNHLLS-----TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN------------SEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF----------RHTISGSQTAIGSSASFGRPTTVEEHHTAIGCN-HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 488          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVN-GDCQNVED--SGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            ++FL++I   ++   G +EKRLL HL +      +N LERPV NES P+EV FG TL QIIDVDEKNQ++ T++WLS+ WNDY+  WN +EYGG+  + + PN +W PDVL+YNSAD  F+      +V+ ++GS  YVPPG+FKSTC +D+TWFPFD Q+C +KFG+W+YDG  ++L +             +    ++  +  +GEW L++   ++    YACC   ++D+  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A++MP +S ++PL+  YF  +M +   S++ TV+VLN HH     H++P +I+ +  QWL  +L +  P        K ++K  ++ ++        + S SLLANVL++  D           R ++S  +T++  + + G    VE+  + + C+ H+DL  + K+L+FIT ++++ D+E + + +WKFAA V+DRFC+I+FTL     T  +  SA
Sbjct:   15 LIFLAII---KESCQGPHEKRLLNHLLS-----TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN------------SEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF----------RHTISGSQTAIGSSASFGRPTTVEEHHTAIGCN-HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 488          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVN-GDCQNVED--SGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            ++FL++I   ++   G +EKRLL HL +      +N LERPV NES P+EV FG TL QIIDVDEKNQI+ T+ WL++ WNDY+  WN +EYGG+  + + PN +W PDVL+YNSAD  F+      +V+ ++GS  YVPPG+FKSTC +D+TWFPFD Q+C +KFG+W+YDG  ++L +             +    ++  +  +GEW L++   ++    YACC   ++D+  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A+ +PQ S ++PLL  YF  +M +   S++ TV+VLN HH     H++P +I+ +  QWL  +L +  P        K ++K  ++ ++        + S SLLANVL++  D           R ++S  +T++  + + G    VE+  + + C+ H+DL  + K+L+FIT ++++ D+E + + +WKFAA V+DRFC+I+FTL     T  +  SA
Sbjct:   15 LIFLAII---KESCQGPHEKRLLNHLLS-----TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN------------SEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF----------RHTISGSQTAIGSSASFGRPTTVEEHHTAIGCN-HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 488          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVN-GDCQNVED--SGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            ++FL++I   ++   G +EKRLL HL +      +N LERPV NES P+EV FG TL QIIDVDEKNQI+ T+ WL++ WNDY+  WN +EYGG+  + + PN +W PDVL+YNSAD  F+      +V+ ++GS  YVPPG+FKSTC +D+TWFPFD Q+C +KFG+W+YDG  ++L +             +    ++  +  +GEW L++   ++    YACC   ++D+  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A++MP +S ++PL+  YF  +M +   S++ TV+VLN HH     H++P +I+ +  QWL  +L +  P        K ++K  ++ ++        + S SLLANVL++  D           R ++S  +T++  + + G    VE+  + + C+ H+DL  + K+L+FIT ++++ D+E + + +WKFAA V+DRFC+I+FTL     T  +  SA
Sbjct:   15 LIFLAII---KESCQGPHEKRLLNHLLS-----TYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLN------------SEDGGDLSDFITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP------GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDF----------RHTISGSQTAIGSSASFGRPTTVEEHHTAIGCN-HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSA 488          

Query:  181 FLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYN--SKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV----------------NGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            F +    +R    G +++RL + L     +  +NPLERPV N++  + V F  +L QI+DVDEKNQ++ T+IWL + W DY+  WN SEY G+T +    + +W PD+LLYNSAD  F+A     V+++  G+  Y+PPG+FKSTC +DV WFPFD+Q C LKFG+W+Y G  ++L++                + ++  Y  +GEW+L+    RR  + Y CC+  + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV VL  H++D    K+P++ RV++  W A  L +  P          +K+P   +     N    V+ S   N+L +           F+   ++  + TS D  V                     +V  SG       +L K+  ++ +I+ + ++ DEE     EWKFAA VIDR C++ F+L     T GI  SA  F
Sbjct:   10 FTTTCCLWRVSLQGEHQRRLYRDL-----MKDYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYDYYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKSTCYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQM---------------IDADITGYIANGEWDLVEVPGRRNERFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPACHNKQPRSSLSSVDLNISPGVAQSTNGNLLYIG----------FRGMDTI-HYATSPDSGVICSRLVATGEEDVLLPGAQASSVSSSG---PGETELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNF 499          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYN--SKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV----------------NGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL + L        +NPLERPV N++  + V F  +L QI+DVDEKNQ++ T+IWL + W DY+  WN SEY G+T +    + +W PD+LLYNSAD  F+A     V+++  G+  Y+PPG+FKSTC +DV WFPFD+Q C LKFG+W+Y G  ++L++                + ++  Y  +GEW+L+    RR  + Y CC+  + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV VL  H++D    K+P++ RV++  W A  L +  P          +K+P   +     N    V+ S   N+L +           F+   ++  + TS D  V                     +V  SG       +L K+  ++ +I+ + ++ DEE     EWKFAA VIDR C++ F+L     T GI  SA  F
Sbjct:   24 GEHQRRLYRDLMK-----DYNPLERPVFNDTHSLTVYFSMSLMQIMDVDEKNQVLTTNIWLQLYWYDYYLQWNASEYPGVTNVRFPDSQIWKPDILLYNSADERFDATFHTNVLVNSSGACQYLPPGIFKSTCYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQM---------------IDADITGYIANGEWDLVEVPGRRNERFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPACHNKQPRSSLSSVDLNISPGVAQSTNGNLLYIG----------FRGMDTI-HYATSPDSGVICSRLVATGEEDVLLPGAQASSVSSSG---PGETELSKILDEVRYISKRFRDQDEEDTVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNF 500          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCS--------------------LHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            V FLS+ L +     G Y+++L K L     ++ +N LERPV N+S P+ V  G TL QIIDVDEKNQ++ T+ WL + W D +  WNP  Y G+  +    N +W PD+LLYNSAD  F+A     V+++  G+  Y+PPG+ KSTC +DV WFPFD+Q C LKFG+W+++G  ++L++Q                V++  Y  +GEW+L+    +R    Y CC+  + DV  T+ + RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TV+VL  HH+D    K+PR++RVI+  W A  L +  P      + K  + P          S +   ++      ++ T N + +L+           S+D A    C    DSG+ CS                       ++ ++  ++ +I  + ++ DE      EWKFAA V+DR C++ F+L +   T  I  SA  F
Sbjct:    5 VYFLSIFLSYIGSLQGEYQRKLYKEL-----MENYNRLERPVLNDSAPIVVELGLTLLQIIDVDEKNQVLITNAWLQLGWTDVYLSWNPDNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFHTNVLVNASGACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQMQ---------------AVDISTYIPNGEWDLVGVPGKRNELYYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPQGGKMPRWVRVILLNWCAWFLRMKKPGEERKANFKYDQSPA----HHASASSIQMGVMPGQPSSTNSTTNGHMNLYFGYH-------SIDSAC---CPPSSDSGVSCSGGRVGGSPNEEQREGVRMFAGEPEIHRILAEVMYIAQRFRDQDEAEAICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNF 498          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPP--DSI-CTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELS-SDTHNIYQDLFKKRKSLSE--FETSVDDAVNGDCQ---NVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL + L     +  +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ T+IWL + W DY+  WN S+Y G+  +    + +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                N ++  Y  +GEW+L+    RR  + Y CC+  + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  H++D    K+P++ RV++  W A  L +  P  D I      K +++  V   +   +     +   N+L         ++    +    L       S DD +    Q    V    +  +L  +L K+ +++ +I  + ++ D +     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:   54 GEHQRRLYRDL-----MKNYNPLERPVYNDSHSLTVHFSFSLMQIMDVDEKNQVLTTNIWLQLYWTDYYLRWNMSDYPGVNTVRFPDSLIWRPDILLYNSADERFDATFHTNVLVNSSGYCQYLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWALDLQM---------------INADITGYIANGEWDLVEVPGRRNEKFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVLVLQYHYHDPDGAKMPKWTRVLLLNWCAWFLRMRRPGEDRIRLACHNKPARRSSVSSVELSVSQGALQAAGGNMLYFGFRGMEGVHYTAHESHSVLCSRLMANSEDDVLLPGAQIRGGVTSGIVGGTLELELAKILEEVRYIAKRFRDQDADESVCNEWKFAAAVIDRLCLMAFSIFTILCTIGILMSAPNF 535          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCS--------------------LHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            V FLS+ L +     G Y+++L K L     ++ +N LERPV N+S P+ V  G TL QIIDVDEKNQ++ T+ WL + W D +  WNP  Y G+  +    N +W PD+LLYNSAD  F+A     V+++  G+  Y+PPG+ KSTC +DV WFPFD+Q C LKFG+W+++G  ++L++Q                V++  Y  +GEW+L+    +R    Y CC+  + DV  T+ + RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TV+VL  HH+D    K+PR++RVI+  W A  L +  P      + K  + P          S +   ++      ++ T N + +L+           S+D A    C    DSG+ CS                       ++ ++  ++ +I  + ++ DE      EWKFAA V+DR C++ F+L +   T  I  SA  F
Sbjct:   12 VYFLSIFLSYIGSLQGEYQRKLYKEL-----MENYNRLERPVLNDSAPIVVELGLTLLQIIDVDEKNQVLITNAWLQLGWTDVYLSWNPDNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFHTNVLVNASGACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQMQ---------------AVDISTYIPNGEWDLVGVPGKRNELYYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPQGGKMPRWVRVILLNWCAWFLRMKKPGEERKANFKYDQSPA----HHASASSIQMGVMPGQPSSTNSTTNGHMNLYFGYH-------SIDSAC---CPPSSDSGVSCSGGRVGGSPNEEQREGVRMFAGEPEIHRILAEVMYIAQRFRDQDEAEAICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNF 505          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNG--DCQNVEDSGMLCSLHE-----DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G Y+++L K L     +  +NPLERPV N+S P+ V FG +L QI+DVDEKNQ++ T+IWL + W DY+  WN SEY G+  +      +W PD+LLYNSAD  F+A+    V+++  G   Y+PPG+FKS+C +DV WFPFD+Q C LKFG+W+Y G  ++L++                  ++  Y  +GEW+L+    +R+   Y CC+  ++DV  TI++ RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D     +P++ R+I+  W A  L +  P           K  PV   K    S  S  +     + SS+ + +Y   F+  + +    T     + G   C   +D  +L ++H      DL K+ ++L +I  + ++ D++     EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   25 GEYQRKLYKEL-----MKNYNPLERPVLNDSHPLTVYFGMSLMQIMDVDEKNQVLTTNIWLQMQWIDYYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDASFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDIQKCNLKFGSWTYGGWSLDLQM---------------LESDISEYISNGEWDLVGVPGKRSENYYECCKEPYLDVTFTIIMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPHGGNMPKWTRIILLNWCAWFLRMKRPGE--------DKVRPVCQHKERRCSMTSVDVNTVSGQQSSNGNMLYIG-FRGLEGIHCTPTPDSGVICGRMTCSPTDDENLLHNVHHSEGDPDLSKILEELRYIANRFRDQDDDESICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNF 495          

Query:  193 ILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANV-LELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNG------DCQNVEDSGMLC--SLHEDLKKVKKQLE---FITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFS 1692
            + F +  + G Y+++L + L        +N LERPV N+S P+ V    TL QIIDVDEKNQ++ T+ WL I WND++  W+ +EY G+  +    + +W+PD+LLYNSAD  F+A     V+++  G+  Y+PPG+ KSTC +DV WFPFDVQ C LKFG+W+++G  ++L++                  ++  Y  +GEW+L+    +R    Y CC+  + DV  T+ + RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S+MV+  LS++ TV+VL  HH+D    K+P+ +RVI+  W A  L +  P          +K+P  I  K IY +   HS ++++ + ++    +   ++        E      ++ +G      +C ++EDS ++   SL E + ++ K LE   +I  + +E D   +   EWKFAA VIDR C++ F+L A   T  I  SA  F+
Sbjct:    6 LFFSKGSHQGQYQRKLYRELLR-----NYNRLERPVVNDSQPLLVELQLTLLQIIDVDEKNQVLITNAWLQITWNDFYLTWDQAEYPGVQTLRFPADHIWVPDILLYNSADERFDATFHTNVLVNSTGACQYIPPGILKSTCYIDVRWFPFDVQKCKLKFGSWTHNGWLLDLQMM---------------EADISSYIPNGEWDLVGVPGKRNELYYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQAGKMPKMVRVILLNWCAWFLRMRKPGE--------NKRP--IPCKYIYPNH--HSSISSIEMNIAPGHQSTNGNIVYCGYHTLESPCCPPNSDSGVMCARVNCPSLEDSDLIQKKSLKESMPEIVKILEEVQYIARRFREQDAGEEICSEWKFAAAVIDRLCLVAFSLFAIIATFTILMSAPNFT 488          

Query:  241 LKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHE------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFS 1692
            ++H    + + ++NP  RPV N S PV + F  +++Q++ VDE NQI++T++WL  +WNDY   WNPS+YGGI  + +  + +W PD++LYN+A   F+  +  K V+ Y G ++++PP +FKS+C +DVT+FPFD QNC+LKFG+W+YD   +NL +                 + +  +  SGEW +I++   +   +Y CC   + D+  ++ I R   +Y    ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++      L KV+F+T P+         + KP   +D  I +S++           S      YQD       L    TS D A N    +  +S     LH       ++++  + + FI   +K  DE  +   +WK+ A VIDR  + +F L+    T G+F   + FS
Sbjct:   27 VEHRLYEDLLKSYNPYIRPVMNVSDPVILHFEVSMSQLVKVDEVNQIMETNLWLRHLWNDYKLKWNPSDYGGIEFLRIPASQIWRPDIVLYNNAVGAFHVDDKAKAVVRYSGDVTWIPPAIFKSSCKIDVTFFPFDYQNCSLKFGSWTYDKAKINLVM-------------IGSKINLKEFWESGEWVIINAPGYKHEIKYNCCVEIYQDITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPSDCGEKVTLCMSVLLSLTVFLLVITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMPHWVKRFFLHLLPKVMFMTRPE-----KQPYALKPQAYLD--ISSSEIR----------SCQDQLFYQDSSCACGQLKRLYTS-DTACNVTRGSSLESMYNLGLHSGSGLSPEIREAIEDVHFIAENMKAQDEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFLQPLLFS 488          

Query:  241 LKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHE------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFS 1692
            ++H    + + ++NP  RPV N S PV + F  +++Q++ VDE NQI++T++WL  +WNDY   WNPS+YGGI  + +  + +W PD++LYN+A   F+  +  K V+ Y G ++++PP +FKS+C +DVT+FPFD QNC+LKFG+W+YD   +NL +                 + +  +  SGEW +I++   +   +Y CC   + D+  ++ I R   +Y    ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++      L KV+F+T P+         + KP   +D  I +S++           S      YQD       L    TS D A N    +  +S     LH       ++++  + + FI   +K  DE  +   +WK+ A VIDR  + +F L+    T G+F   + FS
Sbjct:   24 VEHRLYEDLLKSYNPYIRPVMNVSDPVILHFEVSMSQLVKVDEVNQIMETNLWLRHLWNDYKLKWNPSDYGGIEFLRIPASQIWRPDIVLYNNAVGAFHVDDKAKAVVRYSGDVTWIPPAIFKSSCKIDVTFFPFDYQNCSLKFGSWTYDKAKINLVM-------------IGSKINLKEFWESGEWVIINAPGYKHEIKYNCCVEIYQDITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPSDCGEKVTLCMSVLLSLTVFLLVITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMPHWVKRFFLHLLPKVMFMTRPE-----KQPYALKPQAYLD--ISSSEIR----------SCQDQLFYQDSSCACGQLKRLYTS-DTACNVTRGSSLESMYNLGLHSGSGLSPEIREAIEDVHFIAENMKAQDEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFLQPLLFS 485          

Query:  241 LKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHE------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFS 1692
            ++H    + + ++NP  RPV N S PV + F  +++Q++ VDE NQI++T++WL  +WNDY   WNPS+YGGI  + +  + +W PD++LYN+A   F+  +  K V+ Y G ++++PP +FKS+C +DVT+FPFD QNC+LKFG+W+YD   +NL +                 + +  +  SGEW +I++   +   +Y CC   + D+  ++ I R   +Y    ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++      L KV+F+T P+         + KP   +D  I +S++           S      YQD       L    TS D A N    +  +S     LH       ++++  + + FI   +K  DE  +   +WK+ A VIDR  + +F L+    T G+F   + FS
Sbjct:   19 VEHRLYEDLLKSYNPYIRPVMNVSDPVILHFEVSMSQLVKVDEVNQIMETNLWLRHLWNDYKLKWNPSDYGGIEFLRIPASQIWRPDIVLYNNAVGAFHVDDKAKAVVRYSGDVTWIPPAIFKSSCKIDVTFFPFDYQNCSLKFGSWTYDKAKINLVM-------------IGSKINLKEFWESGEWVIINAPGYKHEIKYNCCVEIYQDITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPSDCGEKVTLCMSVLLSLTVFLLVITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMPHWVKRFFLHLLPKVMFMTRPE-----KQPYALKPQAYLD--ISSSEIR----------SCQDQLFYQDSSCACGQLKRLYTS-DTACNVTRGSSLESMYNLGLHSGSGLSPEIREAIEDVHFIAENMKAQDEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFLQPLLFS 480          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R  + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ R+I+  W A  L +  P           K  P    K    S  S  L A     +S+ + +Y   F+  + +    T     V G   C    D  ++   H      DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRRLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQ---------------EADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGE--------DKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIG-FRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  211 VNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSH-SLLANVLELSSDTHNIYQD-----LFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAV 1683
             +A   E RL ++LF     + +N + RPV N S PV + F  +++Q++ VDE NQI++T++WL  IWNDY   W PS+Y G+  + V    +W PD++LYN+AD +F   +  K ++ Y G ++++PP +FKS+C +DVT+FPFD QNCT+KFG+WSYD   ++L +                ++ +  Y  SGEW +I +   +   +Y CCE  + D+  ++ I R   +Y  N ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++ +    L +V+F+T P S    + K          +  Y +++S+ +  +     S       QD        +R  +S F  ++  + +   ++V+    L +L  ++K+  + +++I   +K  +   +   +WK+ A VIDR  + +F L+    T G+F   +
Sbjct:   28 ASASEAEHRLFQYLF-----EDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL-------------IGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKT---------RNFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSS--ESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPL 498          

Query:  211 VNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSH-SLLANVLELSSDTHNIYQD-----LFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAV 1683
             +A   E RL ++LF     + +N + RPV N S PV + F  +++Q++ VDE NQI++T++WL  IWNDY   W PS+Y G+  + V    +W PD++LYN+AD +F   +  K ++ Y G ++++PP +FKS+C +DVT+FPFD QNCT+KFG+WSYD   ++L +                ++ +  Y  SGEW +I +   +   +Y CCE  + D+  ++ I R   +Y  N ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++ +    L +V+F+T P S    + K          +  Y +++S+ +  +     S       QD        +R  +S F  ++  + +   ++V+    L +L  ++K+  + +++I   +K  +   +   +WK+ A VIDR  + +F L+    T G+F   +
Sbjct:   23 ASASEAEHRLFQYLF-----EDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL-------------IGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSTEEDAPKT---------RNFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSS--ESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPL 493          

Query:  193 ILFFRDVNAGSYEKRLLKHLFNPNRVDAH-NPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAV 1683
            +  F+       E++L   LF      AH N   RPV+N S PV V F   +TQ+ +VDE NQI++T++WL  IW DY   W+P+EY GI  + V  + +W PD++LYN+A  +F      K ++ YDG +++ PP +FKS+C MD+T+FPFD QNC+LKFG+W+YD  +++L I                 V+M  +  + EWE++ +   +   +Y CCE  + D+  +  I R   +Y  N ++PC+ IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P++++ I  Q    +L +  P  +         K P    K     K +H   + +L+              KR+S  +    V        +N E S        D++ V + ++FI   +K ++E  +   +WK+ A V+DR  + +F ++    T G+F   +
Sbjct:   22 LALFKGSTGCESEEQLFHRLF------AHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI-------------IGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKP--LDKTKEAGGVKDPKSHTKRPAKVKFTHRGESKLLKECHHCQKSSDIAPGKRRSSQQPARWV-------AENSEHSS-------DVEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPL 487          

Query:  211 VNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHH---NDHKVPRFIRVIINQWLAKVLFITPPDS 1254
             +A   E RL ++LF     + +N + RPV N S PV + F  +++Q++ VDE NQI++T++WL  IWNDY   W PS+Y G+  + V    +W PD++LYN+AD +F   +  K ++ Y G ++++PP +FKS+C +DVT+FPFD QNCT+KFG+WSYD   ++L +                ++ +  Y  SGEW +I +   +   +Y CCE  + D+  ++ I R   +Y  N ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN H+     H +P +++ +    L +V+F+T P S
Sbjct:   23 ASASEAEHRLFQYLF-----EDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL-------------IGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTS 355          

Query:  205 RDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNG--DCQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            R+   G ++++L K L        +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ C LKFG+W+Y G  ++L++Q                 ++  Y  +GEW+L+    +RT   Y CC+  + D+  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  +     +  S+ + +Y   F+    +    T+    + G   C   E+  +L S H      DL K+ +++ +I  + ++ DEE     EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   18 RESLQGEFQRKLYKELLK-----NYNPLERPVANDSQPLTVYFTLSLMQIMDVDEKNQVLTTNIWLQMYWTDHYLQWNVSEYPGVKNVRFPDGLIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGGWSLDLQMQ---------------EADISGYISNGEWDLVGIPGKRTESFYECCKEPYPDITFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLSSMEMNTVSGQQCSNGNMLYIG-FRGLDGVHCTPTTDSGVICGRMTCSPTEEENLLHSGHPSEGDPDLAKILEEVRYIANRFRDQDEEEAICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R  + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ R+I+  W A  L +  P           K  P    K    S  S  L A     +S+ + +Y   F+  + +    T     V G   C    D  ++   H      DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRRLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQ---------------EADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGE--------DKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIG-FRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R  + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ R+I+  W A  L +  P           K  P    K    S  S  L A     +S+ + +Y   F+  + +    T     V G   C    D  ++   H      DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRRLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQ---------------EADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGE--------DKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIG-FRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  SGEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPSGEWDLVGIPGKRSEKFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGMHCAPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGD--CQNVEDSGMLCSLH-----EDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G ++++L K L     V  +NPLERPV N+S P+ V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN SEY G+  +      +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKS+C +DV WFPFDVQ+C LKFG+WSY G  ++L++Q                 ++  Y  +GEW+L+    +R+ + Y CC+  + DV  T+ + RR  YY  N ++PC++ISA+ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF S M++  LS++ TVIVL  HH+D    K+P++ RVI+  W A  L +  P           K  P    K    S  S  + A     +S+ + +Y   F+    +    T     V G   C    D  +L          DL K+ +++ +I  + +  DE      EWKFAA V+DR C++ F++     T GI  SA  F
Sbjct:   23 GEFQRKLYKEL-----VKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ---------------EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGE--------DKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNF 493          

Query:  217 AGSYEKRLLKHLFNP----NRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXX--------XXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNS------------------KVSHSLLANVLELSSDTHNIYQDLFKKRK---------SLSEFETSVDDAVNGDCQN-----------VEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            AG +E+RLL +LF+P    N ++ HN +ERPVKNES  + V F  +L QIID+DEKNQI+  +IWL + W+DYHF W+P ++GGIT IN+ P  VW PD+LLYNSAD  F+      VVI + G+M+++PPG+F+STC +D TWFPFD Q C LKFG+WSYDG  ++L+++  N + S            S IG  ++  Y  SGEW L   D +RT   Y CC   FID+   I I RR  YY  N ++PC++IS+++LL F+LP DAGEKISLGVTIMLSLSMFQLL+AD MPQ+S S+PL+ +YF   MV+ +LS++FTVIVLN HH D   H VP +++  I  +LA +L +           +  +K PV + +    S                  + S SLLANVL+L  D   +                  S   ++  +  +++G  +                G  CS   +L  V ++L+ IT KI ++  +G+   EWKFAA V+DR C+IIF+      T  I FSA
Sbjct:   22 AGLHERRLLYYLFDPANRTNPLEVHNSMERPVKNESNVLYVWFKVSLQQIIDLDEKNQILFANIWLDLTWHDYHFMWDPKDFGGITKINIDPKRVWRPDILLYNSADEKFDGTYPTNVVIEHTGNMNFIPPGMFRSTCKIDTTWFPFDTQVCKLKFGSWSYDGGTLDLRLKCSNESLSTNEMRLNDPNNCSEIGGADLETYVPSGEWYLEGMDGKRTAAEYDCCPYPFIDLSYFIQIRRRTLYYGINLIIPCVLISSMSLLTFVLPPDAGEKISLGVTIMLSLSMFQLLVADAMPQTSESVPLIGMYFSCTMVMCSLSVVFTVIVLNYHHRDAESHPVPNWVKKFICTYLANILCMRN-------HHRDEEKEPVYLRRRKNASFRTSSYREAANANVELKERSSKSLLANVLDLEDDIRTVGGVGGVGVSGIGASAGAFSPPTYQNVMGSSMDGGAERGGGGGGGGGGGGPSCGSNCSTRNELAAVVRELQVITKKIADDTADGEISSEWKFAARVVDRLCLIIFSCFTVISTCAILFSA 555          

Query:  217 AGSYEKRLLKHLFNP----NRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXX--------XXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNS------------------KVSHSLLANVLELSSDTHNIYQDLFKKRK---------SLSEFETSVDDAVNGDCQN-------------VEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            AG +E+RLL +LF+P    N ++ HN +ERPVKNES  + V F  +L QIID+DEKNQI+  +IWL + W+DYHF W+P ++GGIT IN+ P  VW PD+LLYNSAD  F+      VVI + G+M+++PPG+F+STC +D TWFPFD Q C LKFG+WSYDG  ++L+++  N + S            S IG  ++  Y  SGEW L   D +RT   Y CC   FID+   I I RR  YY  N ++PC++IS+++LL F+LP DAGEKISLGVTIMLSLSMFQLL+AD MPQ+S S+PL+ +YF   MV+ +LS++FTVIVLN HH D   H VP +++  I  +LA +L +           +  +K P+ + +    S                  + S SLLANVL+L  D   +                  S   ++  +  +++G  +                  G  CS   +L  V ++L+ IT KI ++  +G+   EWKFAA V+DR C+IIF+      T  I FSA
Sbjct:   22 AGLHERRLLYYLFDPANRTNPLEVHNSMERPVKNESNVLYVWFKVSLQQIIDLDEKNQILFANIWLDLTWHDYHFMWDPKDFGGITKINIDPKRVWRPDILLYNSADEKFDGTYPTNVVIEHTGNMNFIPPGMFRSTCKIDTTWFPFDTQVCKLKFGSWSYDGGTLDLRLKCSNESLSTNEMRLNDPNNCSEIGGADLETYVPSGEWYLEGMDGKRTAAEYDCCPYPFIDLSYFIQIRRRTLYYGINLIIPCVLISSMSLLTFVLPPDAGEKISLGVTIMLSLSMFQLLVADAMPQTSESVPLIGMYFSCTMVMCSLSVVFTVIVLNYHHRDAESHPVPNWVKKFICTYLANILCMRN-------HHRDEEKEPIYLRRRKNASFRTSSYREAANANVELKERSSKSLLANVLDLEDDIRTVGGVGGVGVSGIGASAGAFSPPTYQNVMGSSMDGGAERGGGGGGGGGGGGGGPSCGSNCSTRNELAAVVRELQVITKKIADDTADGEISSEWKFAARVVDRLCLIIFSCFTVISTCAILFSA 557          

Query:  202 FRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            F+    G +EKRLL HL N   +D +N LERPV NES  +EV FG TL QIIDVDEKNQ++ T+IWLS+ WNDY+  WN SEYGG+  + + PN +W PDVL+YNSAD  F+      VV+ +DGS  YVPPG+FKSTC MD+TWFPFD QNC +KFG+W+YDG  + L+++            +    ++  +  +GEW L+     + V  Y CC   +IDV  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A++MP +S ++PL+  YF  +M +   S++ TV+VLN HH     H++P +++ +  QWL  +L +  P        K ++K  ++ ++        + S SL+AN+L++  D  +          + S F         G    ++DSG       +L+ + ++L+FIT ++K+ DEE + + +WKFAA V+DRFC+I+FT+     T  +  SA
Sbjct:   17 FQSSMQGPHEKRLLNHLLN---MDTYNTLERPVANESEALEVKFGLTLQQIIDVDEKNQLLITNIWLSLEWNDYNLRWNASEYGGVKDLRITPNKIWRPDVLMYNSADEGFDGTYHTNVVVRHDGSCLYVPPGIFKSTCKMDITWFPFDDQNCKMKFGSWTYDGSQLQLELK------------SEEGGDLSDFITNGEWYLLGMPGVKNVLTYQCCPESYIDVTFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPNWVKSVFLQWLPWILGMNRP------GKKITRKTILMTNRMKELHLPDRSSKSLMANILDIDDDFRHC-------STANSSFMRGGGVGGGGGGITLDDSGPCTLAQRELQLIVRELQFITNRMKKADEEAELISDWKFAAMVVDRFCLIVFTMFTIIATVAVLLSA 487          

Query:  169 LNVLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            +  L L V+L F+    G +EKRLL HL N   +D +N LERPV NES  +EV FG TL QIIDVDEKNQI+ T+ WL++ W DY+  WN SEYGG+  + + PN +W PDVL+YNSAD  F+      VV+ +DGS  YVPPG+FKSTC MD+TWFPFD QNC +KFG+W+YDG  + L+++            +    ++  +  +GEW L+     + V  Y CC   +IDV  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A+ +PQ S ++PLL  YF  +M +   S++ TV+VLN HH     H++P +++ +  QWL  +L +  P        K ++K  ++ ++        + S SL+AN+L++  D  +          + S F         G    ++DSG       +L+ + ++L+FIT ++K+ DEE + + +WKFAA V+DRFC+I+FT+     T  +  SA
Sbjct:    6 ITALLLHVVLQFQSSMQGPHEKRLLNHLLN---MDTYNTLERPVANESEALEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWTDYNLMWNASEYGGVKDLRITPNKIWRPDVLMYNSADEGFDGTYHTNVVVRHDGSCLYVPPGIFKSTCKMDITWFPFDDQNCKMKFGSWTYDGSQLQLELK------------SEEGGDLSDFITNGEWYLLGMPGVKNVLTYQCCPESYIDVTFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPNWVKSVFLQWLPWILGMNRP------GKKITRKTILMTNRMKELHLPDRSSKSLMANILDIDDDFRHC------SSTANSSFMRGGSGGGGGGI-TLDDSGPCTLAQRELQLIVRELQFITNRMKKADEEAELISDWKFAAMVVDRFCLIVFTMFTIIATVAVLLSA 487          

Query:  202 FRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTI---YNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            F+    G +EKRLL HL N   +D +N LERPV NES  +EV FG TL QIIDVDEKNQI+ T+ WL++ WNDY+  WN SEYGG+  + + PN +W PDVL+YNSAD  F+      VV+ +DGS  YVPPG+FKSTC MD+TWFPFD QNC +KFG+W+YDG  + L+++            +    ++  +  +GEW L+     + V  Y CC   +IDV  TI I RR  YY FN ++PC++IS++ALL F LP D+GEK++LGVTI+LSL++F  L+A+ +PQ S ++PLL  YF  +M +   S++ TV+VLN HH     H++P +++ +  QWL  +L +  P        K ++K  ++ ++        + S SL+AN+L++  D  +          + S F         G    ++DSG       +L+ + ++L+FIT ++K+ DEE + + +WKFAA V+DRFC+I+FT+     T  +  SA
Sbjct:   17 FQSSMQGPHEKRLLNHLLN---MDTYNTLERPVANESEALEVKFGLTLQQIIDVDEKNQILTTNAWLNLEWNDYNLRWNASEYGGVKDLRITPNKIWRPDVLMYNSADEGFDGTYHTNVVVRHDGSCLYVPPGIFKSTCKMDITWFPFDDQNCKMKFGSWTYDGSQLQLELK------------SEEGGDLSDFITNGEWYLLGMPGVKNVLTYQCCPESYIDVTFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPNWVKSVFLQWLPWILGMNRP------GKKITRKTILMTNRMKELHLPDRSSKSLMANILDIDDDFRHC-------STANSSFMRGGGVGGGGGGITLDDSGPCTLAQRELQLIVRELQFITNRMKKADEEAELISDWKFAAMVVDRFCLIVFTMFTIIATVAVLLSA 487          

Query:  193 ILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV-NGDCQNVEDSGMLCS------------LHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            I  +R    G +++RL + L     +  +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ ++IWL + W D++  WN S+Y G+T +    N +W PD+LLYNSAD  F+A     VV+S DGS  Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                  ++  Y  +GEW+L+    +R  + Y CC   + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV VL  H++D    K+P + R+++  W A  L +  P     +    +K+P   I     ++ V  S   N+L +           F+  +S+  + TS D  V  G   +  +  +L S            +  +L K+ +++ +I+ + ++ DEE     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:   14 ICLWRVSLQGEHQRRLYQDL-----MKNYNPLERPVFNDSQSLTVNFSFSLMQIMDVDEKNQVLTSNIWLQLYWYDHYLKWNLSDYPGVTNVRFPDNQIWKPDILLYNSADERFDATFHTNVVVSADGSCHYLPPGIFKSTCYIDVKWFPFDVQRCALKFGSWTYGGWSLDLQMM---------------EADISGYIANGEWDLVEVQGQRNEKFYDCCREPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPDGGKMPTWTRIVLLNWCAWFLRMKRPGED-RVRPCHNKQPRSSISSVELSTGVPQSTNGNMLYIG----------FRGMESMP-YATSPDSGVICGRLVSAGEEDVLLSTNPAPSISSGGHVDTELAKILEEVRYISKRFRDQDEEETVCSEWKFAASVIDRLCLMAFSIFTILCTIGILMSAPNF 496          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV-NGDCQNVEDSGMLCSLHE------------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL + L     +  +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ ++IWL + W D++  WN S+Y G+T +    N +W PD+LLYNSAD  F+A     VV+S DGS  Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                  ++  Y  +GEW+L+    +R  + Y CC   + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV VL  H++D    K+P + R+++  W A  L +  P     +    +K+P   I     ++ V  S   N+L +           F+  +S+  + TS D  V  G   +  +  +L S +             +L K+ +++ +I+ + ++ DEE     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:   10 GEHQRRLYQDL-----MKNYNPLERPVFNDSQSLTVNFSFSLMQIMDVDEKNQVLTSNIWLQLYWYDHYLKWNLSDYPGVTNVRFPDNQIWKPDILLYNSADERFDATFHTNVVVSADGSCHYLPPGIFKSTCYIDVKWFPFDVQRCALKFGSWTYGGWSLDLQMM---------------EADISGYIANGEWDLVGKG-QRNEKFYDCCREPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPDGGKMPTWTRIVLLNWCAWFLRMKRPGED-RVRPCHNKQPRSSISSVELSTGVPQSTNGNMLYIG----------FRGMESM-PYATSPDSGVICGRLVSAGEEDVLLSTNPAPSISSGGHVDTELAKILEEVRYISKRFRDQDEEETVCSEWKFAASVIDRLCLMAFSIFTILCTIGILMSAPNF 482          

Query:  277 HNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV-NGDCQNVEDSGMLCS------------LHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ ++IWL + W D++  WN S+Y G+T +    N +W PD+LLYNSAD  F+A     VV+S DGS  Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                  ++  Y  +GEW+L+    +R  + Y CC   + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV VL  H++D    K+P + R+++  W A  L +  P     +    +K+P   I     ++ V  S   N+L +           F+  +S+  + TS D  V  G   +  +  +L S            +  +L K+ +++ +I+ + ++ DEE     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:    4 YNPLERPVFNDSQSLTVNFSFSLMQIMDVDEKNQVLTSNIWLQLYWYDHYLKWNLSDYPGVTNVRFPDNQIWKPDILLYNSADERFDATFHTNVVVSADGSCHYLPPGIFKSTCYIDVKWFPFDVQRCALKFGSWTYGGWSLDLQMM---------------EADISGYIANGEWDLVEVQGQRNEKFYDCCREPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPDGGKMPTWTRIVLLNWCAWFLRMKRPGED-RVRPCHNKQPRSSISSVELSTGVPQSTNGNMLYIG----------FRGMESMP-YATSPDSGVICGRLVSAGEEDVLLSTNPAPSISSGGHVDTELAKILEEVRYISKRFRDQDEEETVCSEWKFAASVIDRLCLMAFSIFTILCTIGILMSAPNF 463          

Query:  277 HNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSL-----HED--LKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ T+IWL + W DY+  WN ++Y G+  +    N +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                + ++  Y  +GEW+L+    RR  + Y CC+  + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  HH+D    K+P++ RV++  W A  L +  P      S   +K+       ++  S    +L  N         N+    F+  + +  + TS             DSG+LC        ED  L K+ ++L +I  + +  DE+     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:    4 YNPLERPVFNDSQSLTVHFSFSLMQIMDVDEKNQVLTTNIWLQLYWVDYYLQWNVTDYPGVANVRFPDNQIWRPDILLYNSADERFDATFHTNVLVNSSGYCQYLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQMM---------------DADITGYIANGEWDLVEVPGRRNEKFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVLVLQYHHHDPDGGKMPKWTRVLLLNWCAWFLRMRRPGEERVRSACHNKQLHRGSVSSVELSVSQGALQPN-------NSNMLYIGFRGMEGV-HYTTS------------PDSGVLCGRIMGGSEEDTELAKILEELRYIARRFRNQDEDESVCNEWKFAAAVIDRLCLMAFSIFTILCTFGILMSAPNF 449          

Query:  277 HNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV------NGDCQNVEDSGMLCSLHE--------------------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ T+IWL + W DY+  WN ++Y G+  +    N +W PD+LLYNSAD  F+A     V+++  G   Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                + ++  Y  +GEW+L+    RR  + Y CC+  + DV  T+V+ RR  YY  N ++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  HH+D    K+P++ RV++  W A  L +  P      S   +K+       ++  S    +L  N         N+    F+  + +  + TS D  V       G  ++V   G   S ++                    +L K+ ++L +I  + +  DE+     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:    4 YNPLERPVFNDSQSLTVHFSFSLMQIMDVDEKNQVLTTNIWLQLYWVDYYLQWNVTDYPGVANVRFPDNQIWRPDILLYNSADERFDATFHTNVLVNSSGYCQYLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQMM---------------DADITGYIANGEWDLVEVPGRRNEKFYDCCKEPYPDVTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMVIVGLSVIATVLVLQYHHHDPDGGKMPKWTRVLLLNWCAWFLRMRRPGEERVRSACHNKQLHRGSVSSVELSVSQGALQPN-------NSNMLYIGFRGMEGV-HYTTSPDSGVLCGRIMGGSEEDVLLPGATVSSYQGRVGVGGRVTGGVVGGATETELAKILEELRYIARRFRNQDEDESVCNEWKFAAAVIDRLCLMAFSIFTILCTFGILMSAPNF 480          

Query:  214 NAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVE----------------DSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAV 1683
             A     RL K LF      ++NP  RPV N S PV V F  +++Q++ +DE NQI+ T++WL   WNDY F WNP ++ G+  I V  + +W PD++LYN+AD +F      K ++ YDG++ ++PP +FKS+C +DVT+FPFD QNCT+KFG+W+YD   ++L +                 + +  +  SGEW +I     +   +Y CCE  + D+  ++ + R   +Y  N ++PC++IS + +L F LPSD GEK++L ++++LSL++F L++ + +P +SL +PL+  Y L  M+  TLSI+ T+ VLN H+     H +P ++R +    L K++ + PP    ++ T AS  P  ++ +     +    L A  L  ++ + +         ++ S  E  V        +  +                    LC L  ++++V   +++I   ++  DE  +   +WK+ A V+DR  + +F L+    T G+F   +
Sbjct:    3 RASEAASRLYKTLFT-----SYNPYIRPVFNVSDPVIVRFEVSMSQLVKLDEVNQIMATNLWLKHTWNDYKFQWNPGQFEGMEYIRVPSDKIWKPDIVLYNNADGDFQVEGKTKALLKYDGTVMWMPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL-------------VGTKINLKDFWESGEWVIIDVPGYKHDIKYNCCEQIYPDITYSVYVRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLSISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITIFVLNVHYRTPEAHTMPNWVRRVFLDTLPKIMLLQPPKG--SVGTAAS--PDAVVSEA---DQQPACLCAGELSAAAASSSSSCQSGGISRASSSMEAHVSSVRLPRLRAADVMSDELSSSSSTESLDALLALCLLSPEIRQVIDSVKYIAENLRTQDEAKEVCDDWKYVAMVVDRIFLWVFVLVCILGTAGLFLQPL 486          

Query:  445 EYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPD----------SICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFS 1692
            E+ G+  +   P+ +W PD+LLYNSAD  F+A     V+++Y G+  ++PPG+ KSTC +DV WFPFDVQ C LKFG+W++DG  ++L++                  +   Y  +GEW+L+    +R    Y CC+  + DV  T+ I RR  YY  N ++PC++ISA++LL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+  YF S M++   S++ TVIVL  HH++    K+P+++RVI+  W A  L +  P           SI   ++  S    ++    I+     H +        +       D        + F ++  +   G+ Q          +  ++ K+  +L +I  + +  DE      EWKFAA V+DR C++ FTL     T  I  SA  F+
Sbjct:    2 EHPGVKNLRFQPHQIWTPDILLYNSADERFDATFHTNVLVNYTGNCQHLPPGMLKSTCYIDVRWFPFDVQKCDLKFGSWTHDGWLIDLQM---------------LEADTSGYIANGEWDLVEIPGKRNELYYDCCQEPYPDVTYTLTIRRRTLYYGLNLLVPCVLISALSLLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIGQYFASTMIIVAFSVVVTVIVLQYHHHNPDGKKMPQWVRVILLDWCAWFLRMKQPGRERHELARRLSILHRNSMVSLDLALLSASGIHKKTNGHGVFIGFTNPDAPQQPPTSDSGVMCGRETCFNSTGPEEEPGNAQRGMPPDPTAGMSSEITKILIELRYIAGRFRTQDENEAIASEWKFAAAVVDRLCLLAFTLFTIISTISILMSAPHFT 415          

Query:  229 EKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND----HKVPRFIRVIINQWLAKVL 1233
            E RLLK +        +    RPV   S  VEV FG  + Q++DVDEKNQ++ T++WL   W D +  WNP +YGGI +I V  +++W+PD++LY++AD  F  +   K V+ +DG + + PP ++KS+CT+DVT+FPFD QNC++KFG+W+YDG  V+L                  +V+   Y  +GEWE +++   + V+        +I    + VI R   +Y    ++PC+ +S + +  F LPSD GEKISL  ++++SL++F L++ + +P SS  +PL+  Y L +M+  TLSI+ TV V+N HH      H +  ++R +    L K+L
Sbjct:   35 EDRLLKRMLK-----DYQKWVRPVDKLSDTVEVKFGLGIAQLVDVDEKNQLMTTNVWLKQEWVDINLRWNPDDYGGINSIRVPASSIWLPDIVLYDNADGRFEGSIVTKAVVKHDGRIKWTPPAIYKSSCTIDVTFFPFDQQNCSMKFGSWTYDGTLVDL-------------IMVNSDVDRGEYFDNGEWEFLNATGNKGVRLDGHRFYPYI--TYSFVIRRLPLFYTLFLIVPCLGLSFLTVFVFYLPSDEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIITVFVINVHHRSSSTHHPMAPWVRQLFLHKLPKIL 353          

Query:  550 VKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDH---KVPRFIRVIINQWLAKVLFITPP----DSICTISTKASKKPPVIIDK--------TIYNSKVSHSLLANVLELSSDTHNI-----------YQDLFKKRKSLSEFETSV-------------------------DDAVNGDCQNV--------------EDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
              V++++ G   Y+PPG+ KS+C +DV WFPFDVQ+C LKFG+W++DG  ++L +                + +   Y  +GEW+LI    +R    Y CC+  + DV  T+++ RR  YY  N +LPC++ISA+ALL FLLP+++GEKISLG+T++LSL++F LL+A+ MP +S S+PL+  YF S +++   S++ TV+VL CHH+D     +P ++RV++  W A +L +  P     S     + A  KPP + +          +  +   H+   N     +  HN            Y   F    + S   T+                          +D+    C N+              E     C L   L +V     ++  +++  D       EW+FAA VIDR C+I F+++    T  I  SA +F
Sbjct:   12 TSVLVNHTGGCQYIPPGILKSSCKIDVRWFPFDVQSCDLKFGSWTHDGWLIDLHL---------------LHADTSGYLPNGEWDLIGVVGKRNELFYECCQEPYTDVTYTLLLRRRTLYYALNLLLPCMLISALALLVFLLPAESGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIGQYFASTLMIVGFSVVVTVLVLQCHHHDPDGTNMPTWVRVLLVHWCAWLLRMKQPVRDARSGGPHGSPAPWKPPCLSEHPGTGADRGQVTTATQPHNHSHNNTRGYTGNHNPDNTYAQSQPLNYSQPFNHTHNHSTTITNTQPHSQPPNHTDNHPIAQPRTAAQHHEDSCCPGCPNIAGAAGGEGGGAARQESPLQSCELAGLLAEV----HYLAERMRAADAGARLGGEWRFAAAVIDRLCLIAFSIVTISSTAAILVSAPSF 437          

Query:  325 VLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVI----INQWLAKVLFITPPDS 1254
            V +    T + D DEKNQ++ T++WL   W+DY   W+P+EY  +T+I V    +W+PD++LYN+AD +F   +  K  + + G + + PP ++KS+C++DVT+FPFD QNCT+KFG+W+YD   ++L              S   +V++  Y  SGEW ++ +      ++Y CC   + D+  + +I R   +Y  N ++PC++IS + +L F LPSD GEKI+L ++++LSL++F LL+ + +P +SL +PL+  Y L  M+  TLSI+ TV VLN HH     H +PR++R +    + +WL  V+   PP  
Sbjct:    1 VRYAEFRTHLCDCDEKNQMMTTNVWLKQEWDDYKLQWDPAEYENVTSIRVPSELIWVPDIVLYNNADGDFAVTHMTKAHLFHTGRVRWKPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL-------------VSMARDVDLKDYWESGEWAIVHAVGTYNTKKYDCCPQVYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPATHAMPRWVRRVFLDRVPRWL--VMRRPPPQQ 302          

Query:  229 EKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXX---XVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLN---CHHNDHKVPRFIRVIINQWLAKVLFI---------TPPDSI----CTISTKASKKPPVIIDKTIYNS-KVSHSLLANVLELSSDTHNIY--QDLFKKRKSLSEFET--SVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAF 1650
            E RL + LF       +NP  RPV ++   V V+ G ++ QIIDV EK+QIIKTS W+  IW +    WN + YGGI  INV P  VW PD++LYN+AD + + +      ++++S DG   ++ P +F S+CT+ + +FPFD Q C+LKFG+W++DG  ++LK +                  +  +  +GEW+LI +   R V RY CC   + DV  T+ + RR+ ++LFN ++PC +I  +  L F LP D+GE+IS+ +T +L++++F L++AD +P +S  + ++++++   ++   +++L T IVL    C  + HK+P ++R ++ + L KV            +  D+I    C    +   K P+I     +    V   + ++ ++ +    N+   QD   + +  + + +  ++DD +  +  +      L S  E +    K LE +    +  DEE  +  EWK AA ++D F   +F +  F
Sbjct:   50 EGRLTRDLFA-----GYNPKLRPVFHKRENVTVVLGMSVHQIIDVYEKDQIIKTSFWVRQIWYNPFLRWNETFYGGIKEINVSPLQVWTPDLVLYNNADASTDGSLENFKTRIIVSSDGKNMWLAPVIFSSSCTIKIKYFPFDDQYCSLKFGSWTFDGFHLDLKPEAPQA-------------SLSKFIPNGEWDLIGAPAIRNVLRYDCCPAPYPDVTFTLHLRRRVLFFLFNLIIPCFVIVVLTSLSFYLPPDSGERISVVITNLLAMTVFMLMVADILPPTSDEVSIISIFYSCSIIEVGIALLGTCIVLKYHFCSTSIHKMPPWVRFLVIECLGKVFCRQEHTNDQEDSKSDTIKLDNCKHKLENGLKDPLIKQCNFFGKFGVRERVRSSGMKTTDGGSNLSMTQDDEGRGRGGTPYSSHRNMDDIIAAEASSNSTVFALLSRQESM---VKNLEILAHAQRCQDEEDREKNEWKLAASILDNFFCWLFLMSIF 526          

Query:  226 YEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXX---VKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDHKVPRFIRVIINQWLAKVLFITP 1245
            +E +L+  LF   + DA     RPV N+S  V V      +Q+ID+D KNQI+ + +W+  +W +    WNP +YGG+ +INV  N VW PD++LYN+       A      KVVI  DG+ S+  P   KS C +D+T+FPFD Q+C + FG+W+Y G  +NL              +     ++  Y  SGEWEL S+ + R V +Y+CC+  +IDV  TI I R++ +YL N +LPC++++ + +  FLLP  +GE+ISL +TI+L L++F L+  +++P++S  +PL+A Y  ++M    +S+L T +V+  +H +  +P  +R I+   LA VL + P
Sbjct:    1 WEHKLITTLFKDYQRDA-----RPVYNKSEAVRVSLDIAYSQLIDLDGKNQILSSKVWIRQVWRNPFLSWNPDDYGGLESINVNSNLVWKPDIILYNNIGIGQTGAMYNFDTKVVIDSDGTNSWYAPTEIKSICQIDITYFPFDAQSCPIIFGSWTYTGNYLNL-------------VNARNQSDLSKYTISGEWELKSAPVVRNVVKYSCCKHPYIDVTYTINIRRKVLFYLNNLILPCMVLAILTVCSFLLPPASGERISLVITILLGLTVFMLVFTESVPRTSEVIPLIAKYSFAVMCEVAVSLLLTCVVMRIYHKNSPMPLPMRYIVYNILAPVLRMHP 325          

Query:  205 RDVNAGS-YEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXX---XXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDHK-----VPRFIRVIINQWLAKVLFITPP 1248
            RDVN    +E  LL  L      DAH P+  P+ N++    V FG  L Q+++VD+KNQII T++W+   W +    W+P +YGGIT + +  + +W+PD++LYNSA    +        +V++++DG  ++  P  F+STC +DVT+FPFD Q C +KFG+W+++ VD+++      ++SS              Y +S EW+LI++  +R V+ YACC   F DV +T V  R+  +Y+FN ++PC+II+ + LL F+LP ++GE+I+L +T++L++++F  L A+N+P++S ++P+L ++++++MV   LS++ T  VL+ HH +       VP +++V +  +L K+L +  P
Sbjct:    3 RDVNGSDLHEHTLLGDLLKGYNKDAH-PV--PILNKT-QYMVTFGLELVQLVNVDDKNQIITTNVWVRQRWTNLLLKWDPDKYGGITRVRIDASKIWIPDIVLYNSADSEFSGGLEKYKTRVILNHDGVNAWYSPASFRSTCQIDVTFFPFDQQTCFMKFGSWTFEVVDLDIFADKSPLHSSQ-------------YMKSAEWDLIAASKKRNVEYYACCTYPFSDVTVTWVFRRKPLFYVFNLIVPCLIITGMVLLGFMLPPESGERITLSITVLLAMAVFLQLAAENLPRNSDNVPVLGIFYITVMVEVALSLIATCYVLHIHHKNSGIAVVPVPHWVQVYMLGYLGKILGVKKP 342          

Query:  229 EKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXX---XXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDH------KVPRFIRVIINQWLAKVLFITPP 1248
            E+RL+  L      +A     RPV N +  ++V FG  + QI++V+ +NQII+T++W+   W++    W+PS Y G+  + +   +VW+PD++LY+SAD+ F+         V+IS DGS ++  P  F+STC +DVT+FPFD Q C +KFG+W+Y   DV+++     + SS              Y +S EW+L+S+   R  Q YACC     DV + + I R+  +Y FN + PC+I+  + LL F LP ++GE+I+L +T++L++++F  L+A+ +P++S S+PLL  +++++M    +S++ T  VLN HH +       ++P+++ VI+ +WLA VL +  P
Sbjct:    1 EQRLISDLLQGYSRNA-----RPVLNSNHTLKVFFGMEIVQIVNVENRNQIIQTNVWIRQRWDNELLTWHPSNYEGVQTVRLDAKSVWIPDIVLYDSADSVFSGGHEKYKTHVIISKDGSSAWFSPASFRSTCKIDVTYFPFDEQTCYMKFGSWTYTIADVDIQASPAPVKSSK-------------YLKSAEWDLMSATTSRKSQIYACCPEPISDVTIAMTIRRKPLFYAFNLITPCMIMLTMILLGFFLPPESGERITLSITVLLAMAVFLQLVAETLPRNSESIPLLGRFYITIMTEIAVSLMATCWVLNIHHRNSGTTLVVEMPKWVDVIVLRWLAVVLCVRQP 331          

Query:  277 HNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXX---VKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQ 1068
            + P  RPV +   PV V  G  L QIIDVDEKNQI+ T++W+ + W D+  +WNP ++GG+ +INV PN VW PD+LLYN  D    +       KV++S DGS +++ P + K+ C +DV  FPFDVQ C LKFG+W++DG+ ++++++                V++  Y+ + EW L  +  RR V+ Y CC   +  V  T+VI RR  +Y++N VLP  +I+ ++L  F LP ++GE++S  +T++LS+S++ +++ +NMPQ
Sbjct:    5 YTPEARPVLHVKDPVVVKMGLMLKQIIDVDEKNQILTTNVWIRLYWKDHLLNWNPEDFGGVKSINVEPNNVWKPDILLYNPTDLRVESLYKKIDTKVILSSDGSAAWLSPAIIKTECKVDVRLFPFDVQYCDLKFGSWTHDGLKIDIQLR------------KTTGVDIDDYSENREWFLKDAPGRRDVKLYNCCPEPYPTVTFTLVIRRRAMFYVYNMVLPTGMIALLSLFSFYLPPNSGERVSFVITVLLSMSVYMIMVTENMPQ 259          

Query:  187 SVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSL--SEFETSVDDAVNGD---CQNVEDSGMLCSLHE--------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            S+ L+    + G  ++RL   L +      +NPLERPV N+S  + V FG +L QI+DVDEKNQ++ T+IWL + WND++  WN S+Y G+T +    + +W PD+LLYNSAD  F+A     ++++  G+ SY+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++LK+                  ++  Y  +GEW+L+    +R  + Y CC+  ++D+  T+V+ RR  YY  N +LPC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  HH+D    K+P++ RVI+  W A  L +  P      S   +K     +     N+  S SL  N         N+     +  +SL  S   TS D  V       +  ED  +L S H         +L K+  ++ +I  + ++ DE+     EWKFAA V+DR C++ F+L     T GI  SA  F
Sbjct:   36 SLCLYSVVSHQGPNQRRLYSDLMS-----TYNPLERPVYNDSQSLTVHFGLSLLQIMDVDEKNQVLTTNIWLRLYWNDHYLQWNSSDYPGVTNVRFPDHLIWKPDILLYNSADERFDATFHTNILVNSSGTCSYLPPGIFKSTCYIDVRWFPFDVQRCELKFGSWTYGGWSLDLKM---------------LEADVSGYIANGEWDLVEVPGQRNERFYECCDEPYLDITFTVVMRRRTLYYGLNLLLPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAEYFATTMVIVGLSVIATVLVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDRVRSACDNKTRRSSLTSMDLNAPTSTSLSTN--------GNLLYVGVRGLESLQYSPGATSPDSGVVCGRLITRAGEDEMLLPSSHASSLGNMEMELAKILDEVRYIAKRFRDQDEDESVCNEWKFAASVVDRLCLMAFSLFTILCTIGILMSAPNF 524          

Query:  214 NAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSL--SEFETSVDDAVNGDCQNV-----EDSGMLCSLHE--------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            + G  ++RL   L +      +NPLERPV N+S  + V FG +L QI+DVDEKNQ++ T+IWL + WND++  WN S+Y G+T +    + +W PD+LLYNSAD  F+A     ++++  G+ SY+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++LK+                  ++  Y  +GEW+L+    +R  + Y CC+  ++D+  T+V+ RR  YY  N +LPC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  HH+D    K+P++ RVI+  W A  L +  P      S   +K     +     N+  S SL  N         N+     +  +SL  S   TS D  V   C  +     ED  +L S H         +L K+  ++ +I  + ++ DE+     EWKFAA V+DR C++ F+L     T GI  SA  F
Sbjct:   42 HQGPNQRRLYSDLMS-----TYNPLERPVYNDSQSLTVHFGLSLLQIMDVDEKNQVLTTNIWLRLYWNDHYLQWNSSDYPGVTNVRFPDHLIWKPDILLYNSADERFDATFHTNILVNSSGTCSYLPPGIFKSTCYIDVRWFPFDVQRCELKFGSWTYGGWSLDLKM---------------LEADVSGYIANGEWDLVEVPGQRNERFYECCDEPYLDITFTVVMRRRTLYYGLNLLLPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAEYFATTMVIVGLSVIATVLVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDRVRSACDNKTRRSSLTSMDLNAPTSTSLSTN--------GNLLYVGVRGLESLQYSPGATSPDSGVV--CGRLITRAGEDEMLLPSSHASSLGNMEMELAKILDEVRYIAKRFRDQDEDESVCNEWKFAASVVDRLCLMAFSLFTILCTIGILMSAPNF 521          

Query:  268 VDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSL--SEFETSVDDAVNGDCQNV-----EDSGMLCSLHE--------DLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            +  +NPLERPV N+S  + V FG +L QI+DVDEKNQ++ T+IWL + WND++  WN S+Y G+T +    + +W PD+LLYNSAD  F+A     ++++  G+ SY+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++LK+                  ++  Y  +GEW+L+    +R  + Y CC+  ++D+  T+V+ RR  YY  N +LPC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + MV+  LS++ TV+VL  HH+D    K+P++ RVI+  W A  L +  P      S   +K     +     N+  S SL  N         N+     +  +SL  S   TS D  V   C  +     ED  +L S H         +L K+  ++ +I  + ++ DE+     EWKFAA V+DR C++ F+L     T GI  SA  F
Sbjct:    1 MSTYNPLERPVYNDSQSLTVHFGLSLLQIMDVDEKNQVLTTNIWLRLYWNDHYLQWNSSDYPGVTNVRFPDHLIWKPDILLYNSADERFDATFHTNILVNSSGTCSYLPPGIFKSTCYIDVRWFPFDVQRCELKFGSWTYGGWSLDLKM---------------LEADVSGYIANGEWDLVEVPGQRNERFYECCDEPYLDITFTVVMRRRTLYYGLNLLLPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAEYFATTMVIVGLSVIATVLVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDRVRSACDNKTRRSSLTSMDLNAPTSTSLSTN--------GNLLYVGVRGLESLQYSPGATSPDSGVV--CGRLITRAGEDEMLLPSSHASSLGNMEMELAKILDEVRYIAKRFRDQDEDESVCNEWKFAASVVDRLCLMAFSLFTILCTIGILMSAPNF 467          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVD--------------------DAVNG-DCQNVEDSGMLCS--LHED--------LKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL K L     +  +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN S+Y G+T +    + +W PD+LLYNSAD  F+A+    ++++  G   Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                N +   Y  +GEW+L+    +R+ + Y CC+  + DV  T+V+ RR  YY  NF++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + M +  LS++ TV+VL  HH+D     +P++ RV++  W A  L +  P                        +KV   LLA         HN+ +   ++R SLS  E S++                      V G  C +  D   LC+  + ED        L+++ +++ FI  + +  D+E     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:    7 GVHQRRLYKEL-----IRNYNPLERPVSNDSHSLTVHFSFSLLQIMDVDEKNQVLTTNIWLQLYWKDFYLQWNMSDYPGVTNVRFPDSQIWRPDILLYNSADERFDASFHTNILVNSSGYCQYLPPGIFKSTCHIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQM---------------INADTTGYIANGEWDLVEVPGQRSERFYDCCKEPYPDVTFTVVMRRRTLYYGLNFLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMAIVGLSVIATVLVLQYHHHDPDGGHMPQWTRVVLLNWCAWFLRMRRPG----------------------EAKV---LLA--------CHNMGK---RQRGSLSSLELSINPVSVPPQPHVTNSNLLYVGFQGVEGLHCGSATDPEPLCARFIEEDFLRVGEVELQQILEEVRFIGQRFRNQDQEKAACSEWKFAAAVIDRLCLVAFSVFTILCTIGILMSAPNF 474          

Query:  220 GSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHND---HKVPRFIRVIINQWLAKVLFITPPD-------------------SICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTF 1689
            G +++RL K L     +  +NPLERPV N+S  + V F  +L QI+DVDEKNQ++ T+IWL + W D++  WN S+Y G+T +    + +W PD+LLYNSAD  F+A+    ++++  G   Y+PPG+FKSTC +DV WFPFDVQ C LKFG+W+Y G  ++L++                N +   Y  +GEW+L+    +R+ + Y CC+  + DV  T+V+ RR  YY  NF++PC++IS +ALL FLLP+D+GEKISLG+T++LSL++F LL+A+ MP +S S+PL+A YF + M +  LS++ TV+VL  HH+D     +P++ RV++  W A  L +  P                    S   +S      PP      + NS + +     V  L   +    + L   R    +F              + DS    +L  +L+++ +++ FI  + +  D+E     EWKFAA VIDR C++ F++     T GI  SA  F
Sbjct:    2 GVHQRRLYKEL-----IRNYNPLERPVSNDSHSLTVHFSFSLLQIMDVDEKNQVLTTNIWLQLYWKDFYLQWNMSDYPGVTNVRFPDSQIWRPDILLYNSADERFDASFHTNILVNSSGYCQYLPPGIFKSTCHIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQM---------------INADTTGYIANGEWDLVEVPGQRSERFYDCCKEPYPDVTFTVVMRRRTLYYGLNFLIPCVLISTLALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFATTMAIVGLSVIATVLVLQYHHHDPDGGHMPQWTRVVLLNWCAWFLRMRRPGEAKVLLACHNMGKRQRGSLSSLELSINPVSVPP---QPHVTNSNLLYVGFQGVEGLHCGSATDPEPLC-ARFIEEDFLRVGGGTRRRQGGVLNDS----ALEVELQQILEEVRFIGQRFRNQDQEKAACSEWKFAAAVIDRLCLVAFSVFTILCTIGILMSAPNF 485          

Query:  493 MPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFSG 1695
            MPDVLLYNSADNNFNAANSVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQNVNMNSSNGNDSNIGNVEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQSSLSLPLLALYFLSMMVLSTLSILFTVIVLNCHHNDHKVPRFIRVIINQWLAKVLFITPPDSICTISTKA KKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFSG
Sbjct:    1 MPDVLLYNSADNNFNAANSVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQNVNMNSSNGNDSNIGNVEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQSSLSLPLLALYFLSMMVLSTLSILFTVIVLNCHHNDHKVPRFIRVIINQWLAKVLFITPPDSICTISTKALKKPPVIIDKTIYNSKVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAVNGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSAVTFSG 401          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDG--VDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHH---NDHKVPRFIRVIINQWLAKVLFI---TPPDSICTISTKASKKPPVIIDKTIYNSKVSHS--------LLANVLELSSD--THNIYQDLFKKRKSLSEFETSVDDAVNG-DCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
             +F  +++   + + G  EK+LL++LF+ NR DAHN LERP KN+S PVEV     LTQ+IDVDEKNQII T+IWL + W DYHF WNPS YGGI+   +  + VW PD+LL+NSAD+ F+      VV+     M +VPPG+FKSTC +D+TWFPFD QNCT+KFG+W+Y G  +D+ L+  + + N   G  +    + +  Y  +GE++++   + R   +Y+     ++++ MTI + R+  YY+FN ++PC++IS +ALL+F LP DAGEKISLGVTI+LS++MF LL+AD +PQ+S ++ LL +YF  +M + +LSI+FTV+VLN HH   N   VP  I+ I+N WLAKVLF+   + P+    +  K      +I +    N +   S          ++V ++ SD   H I +     R        S   A N    +  + +   C+   +L  +  +L+ IT KIK++++E    KEWKFAA VIDR C+ +F+L     T  +   A
Sbjct:   13 AVFWLILISLSEFHCGINEKKLLRYLFDQNRPDAHNILERPSKNDSQPVEVRMKAFLTQLIDVDEKNQIIHTNIWLDLKWKDYHFQWNPSVYGGISGFKIPADRVWKPDLLLFNSADDKFDGTYPTNVVVKNSSLMQWVPPGMFKSTCDIDITWFPFDSQNCTVKFGSWTYSGKYIDLRLQCPDDDDNEKTGVCTETSVINLESYVLNGEFDIVDCPINRL--QYSFNNETYMNILMTIRMQRKPLYYIFNLIIPCVLISTMALLEFTLPPDAGEKISLGVTILLSMTMFLLLVADKLPQTSGAISLLGIYFACIMFMCSLSIVFTVLVLNYHHRSVNLKPVPPLIKKIVNTWLAKVLFMKQNSEPEIRNELFQKNDLGSEMIENGLSVNFEKCRSPIDANSKFTFSHVFDVESDFRVHGIGKSKTSFRLPKVPSYMSFKGAENSIPPKTSKATWPSCNSRHELIAILDELKKITQKIKDDEDEITMAKEWKFAARVIDRCCLTVFSLFIIISTFAVLTRA 531          

Query:  175 VLFLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDG--VDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHH---NDHKVPRFIRVIINQWLAKVLFI---TPPDSICTISTKASKKPPVIIDKTIYNSKVSHS--------LLANVLELSSD--THNIYQDLFKKRKSLSEFETSVDDAVNG-DCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
             +F  +++   + + G  EK+LL++LF+ NR DAHN LERP KN+S PVEV     LTQ+IDVDEKNQII T+IWL + W DYHF WNPS YGGI+   +  + VW PD+LL+NSAD+ F+      VV+     M +VPPG+FKSTC +D+TWFPFD QNCT+KFG+W+Y G  +D+ L+  + + N   G  +    + +  Y  +GE++++   + R   +Y+     ++++ MTI + R+  YY+FN ++PC++IS +ALL+F LP DAGEKISLGVTI+LS++MF LL+AD +PQ+S ++ LL +YF  +M + +LSI+FTV+VLN HH   N   VP  I+ I+N WLAKVLF+   + P+    +  K      +I +    N +   S          ++V ++ SD   H I +     R        S   A N    +  + +   C+   +L  +  +L+ IT KIK++++E    KEWKFAA VIDR C+ +F+L     T  +   A
Sbjct:   28 AVFWLILISLSEFHCGINEKKLLRYLFDQNRPDAHNILERPSKNDSQPVEVRMKAFLTQLIDVDEKNQIIHTNIWLDLKWKDYHFQWNPSVYGGISGFKIPADRVWKPDLLLFNSADDKFDGTYPTNVVVKNSSLMQWVPPGMFKSTCDIDITWFPFDSQNCTVKFGSWTYSGKYIDLRLQCPDDDDNEKTGVCTETSVINLESYVLNGEFDIVDCPINRL--QYSFNNETYMNILMTIRMQRKPLYYIFNLIIPCVLISTMALLEFTLPPDAGEKISLGVTILLSMTMFLLLVADKLPQTSGAISLLGIYFACIMFMCSLSIVFTVLVLNYHHRSVNLKPVPPLIKKIVNTWLAKVLFMKQNSEPEIRNELFQKNDLGSEMIENGLSVNFEKCRSPIDANSKFTFSHVFDVESDFRVHGIGKSKTSFRLPKVPSYMSFKGAENSIPPKTSKATWPSCNSRHELIAILDELKKITQKIKDDEDEITMAKEWKFAARVIDRCCLTVFSLFIIISTFAVLTRA 546          

Query:  214 NAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACC-ETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHN---DHKVPRFIRVIINQWLAKVLFITPPDSICTISTKASKKPPVIIDKTIYNSKVSHSLL----------ANVLELSSD-THNIYQDLFKKRKSLSEFETSVDDA-VNGDCQNV-----------EDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVIIFTLLAFCVTGGIFFSA 1680
            + G + KRLL +LFN ++   HN LERPV +E+  +EV F  TL QI+D+DEKNQ++ T+IWL I W DY+F WNP E+G IT + +    VW PD+L+YNSAD  F+      VV++  G M  VPPG+FKSTC +++TWFPFD Q+C +KFGTW+Y G  V+ +++    ++  G   +      L   ++GEWE++     +  + Y CC E+ FID+K  + + R+  YY+FN + PCIIIS ++LL F LP  AGEKI++GVTIMLSL+MF  ++AD +PQ+S S+PL+ LYF  +M++ + S++FTV+VLNCHH    D ++P +++V++N+WLA  L ++P +    ++   ++K  +   ++I    ++HS L           N+    SD + N+        K LS   T  +    N   +N+             S   CS+  +L+ V  +L+ IT KI+E   +  K  EWKFAA VIDRFC+I F L     +  I  SA
Sbjct:   15 HCGYHGKRLLSYLFNDSKFYGHNSLERPVVDENQSLEVQFKVTLLQILDLDEKNQVMNTNIWLDITWTDYNFKWNPLEFGNITTLILPSEKVWKPDILMYNSADEKFDGTYPANVVVTNQGLMHMVPPGMFKSTCKINITWFPFDQQSCVMKFGTWTYTGDKVDFRLKCDEGSNCTGQYGSADTESFL---KNGEWEIVDVPAEKHTETYPCCPESPFIDIKFHVKMRRKALYYIFNLMTPCIIISTMSLLVFTLPPGAGEKITMGVTIMLSLTMFLFMVADKLPQTSGSVPLIGLYFSCIMIMCSFSVVFTVLVLNCHHKSGEDEEMPYWLKVLVNRWLANFLLMSPRNP--QVTNSPTRKIEIQQRRSIL-PNMNHSFLTYENLAPKPYGNITNRKSDGSTNV-----TSTKRLSHIYTQNNSGKANIGAKNIYKNSYIKPMICNHSATKCSIFTELQDVIHELKQITDKIQEEHFDFKKSNEWKFAARVIDRFCLIGFALFTLISSVVILTSA 519          

Query:  181 FLSVILFFRDVNAGSYEKRLLKHLFNPNRVDAHNPLERPVKNESLPVEVLFGTTLTQIIDVDEKNQIIKTSIWLSIIWNDYHFHWNPSEYGGITAINVLPNTVWMPDVLLYXXXXXXXXXXXXVKVVISYDGSMSYVPPGLFKSTCTMDVTWFPFDVQNCTLKFGTWSYDGVDVNLKIQXXXXXXXXXXXXXXXXXEMLYYARSGEWELISSDLRRTVQRYACCETDFIDVKMTIVIGRRITYYLFNFVLPCIIISAVALLDFLLPSDAGEKISLGVTIMLSLSMFQLLLADNMPQXXXXXXXXXXXXXXMMVLSTLSILFTVIVLNCHHNDH---KVPRFIRVIINQWLAKVLFITPPDSICT---ISTKASKKPPVIIDKTIYNS-------KVSHSLLANVLELSSDTHNIYQDLFKKRKSLSEFETSVDDAV-----NGDCQNVEDSGMLCSLHEDLKKVKKQLEFITTKIKENDEEGDKLKEWKFAAYVIDRFCVI 1629
            F  V++  ++  AG  EK+LL+HLF+  R DAHN LERP K++   + V     L QIIDVDEKNQI+ T++W+ + W DYHF W+P  Y  IT + +  N +W PD+LLYNSAD  F+A     +V+ YDG M  VPPG+FKSTC +++ W+PFD Q C +KFG+W+Y+G  ++L     N  + N          ++    +GEW+++S    R+V +Y CC   +ID+   + I RR  YY FN ++PCIIIS +ALL FL+P DAGEKISLGVTI+LSL++F +++A+ MP +S ++PL+ +YF  +M++ +LS++FTV+VLN HH       VP  +  ++N WLA++LF+ P + + +    S    +         IYN        K S SLLANVL    D  N       +  S S    +V+  V       +   +   G+L      +K++   L  +T+K+ E + +  +  EWKFAA V+DRFC++
Sbjct:    7 FFFVLVIAKESFAGKAEKKLLRHLFDNKRTDAHNILERPAKDDKKSLAVYILIFLMQIIDVDEKNQILHTNVWIDLKWTDYHFVWDPIAYNNITTLVIPANRLWRPDILLYNSADERFDATFPANIVVKYDGEMHTVPPGMFKSTCQINIKWYPFDTQKCKMKFGSWTYEGNLIDLLFFCDNATTCNQTFGKGNAENIM---ENGEWDVLSFKAIRSVDKYPCCPETYIDISYYLEIKRRTLYYTFNLIVPCIIISTMALLGFLIPPDAGEKISLGVTILLSLTVFLMMVAEKMPPTSKAIPLIGMYFTCVMIVCSLSLVFTVLVLNFHHRSSDSIDVPESLHKVVNIWLARILFMKPRNKVASEVFESGDLKQNTGQFKRNAIYNRAFQSGSMKGSKSLLANVL----DMENEIWARAAQSVSFSYPSANVNSEVPPYESQNNNGGIMGEGLLPEGRSQIKEILSHLRQVTSKLAETEIQELRANEWKFAARVMDRFCLV 500