glycogen synthase kinase 3

Overview


Name	glycogen synthase kinase 3 (ABD62975.1)
Smed ID	SMED30021687
Length (bp)	2642

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of glycogen synthase kinase 3 (SMED30021687) t-SNE clustered cells

Violin plots show distribution of expression levels for glycogen synthase kinase 3 (SMED30021687) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of glycogen synthase kinase 3 (SMED30021687) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for glycogen synthase kinase 3 (SMED30021687) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30021687

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30021687	h1SMcG0012922	dd_Smed_v4_4762_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30021687	h1SMcG0012922	dd_Smed_v4_4762_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30021687	h1SMcG0012922	ABD62975	smed_ncbi_20240424	PMID:18202849 Adell et al., 2008
ventral nerve cord	SMED30021687	h1SMcG0012922	ABD62975	smed_ncbi_20240424	PMID:18202849 Adell et al., 2008
central nervous system	SMED30021687	h1SMcG0012922	ABD62975	smed_ncbi_20240424	PMID:18202849 Adell et al., 2008
parenchyma	SMED30021687	h1SMcG0012922	ABD62975	smed_ncbi_20240424	PMID:18202849 Adell et al., 2008
epidermis	SMED30021687	h1SMcG0012922	dd_Smed_v4_4762_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 585.489 bits (1508), Expect = 0.000e+0
Identity = 274/378 (72.49%), Postives = 319/378 (84.39%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYIS-KSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +   ++      + TA S
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAAS 398

HSP 2 Score: 58.9214 bits (141), Expect = 2.294e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 582.793 bits (1501), Expect = 0.000e+0
Identity = 274/378 (72.49%), Postives = 319/378 (84.39%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYIS-KSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +   ++      + TA S
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAAS 398

HSP 2 Score: 58.9214 bits (141), Expect = 2.934e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 267/357 (74.79%), Postives = 309/357 (86.55%), Query Frame = 3

Query:  156 NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
             ++  ++TTV AT GQG E++QE++YTD K+IGNGSFGVVYQAR  E++ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDE+YLNLVLE++PETVYRVARH+ K K TIP+L++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+ RT PEAI L + LLEYTPS+R+SP+E+C HSFFDELR   T+LPN++PLPPLFNF++ E+  +  L   LIP ++    G
Sbjct:   94 GRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAG 450

HSP 2 Score: 56.9954 bits (136), Expect = 1.021e-7
Identity = 43/161 (26.71%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR--DYLVKTN-PVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + +E++ E   R   +  K    +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  165 RKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 317

[Close]

Query:  156 NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
             ++  ++TTV AT GQG E++QE++YTD K+IGNGSFGVVYQAR  E++ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDE+YLNLVLE++PETVYRVARH+ K K TIP+L++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+ RT PEAI L + LLEYTPS+R+SP+E+C HSFFDELR   T+LPN++PLPPLFNF++ E+  +  L   LIP ++    G
Sbjct:   94 GRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAG 450

HSP 2 Score: 56.9954 bits (136), Expect = 1.021e-7
Identity = 43/161 (26.71%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR--DYLVKTN-PVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + +E++ E   R   +  K    +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  165 RKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 317

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 274/391 (70.08%), Postives = 319/391 (81.59%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNK-------------VFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYIS-KSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW K             VFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +   ++      + TA S
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAAS 411

HSP 2 Score: 58.9214 bits (141), Expect = 2.808e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: gsk-3 (Glycogen synthase kinase-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2Q9])

HSP 1 Score: 511.531 bits (1316), Expect = 2.240e-175
Identity = 237/334 (70.96%), Postives = 281/334 (84.13%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQGEKTQ--EISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPL 1139
            L  S K G ++T V A+       Q  EISY D K+IGNGSFGVV+ A+   + E+VAIKKVLQD+RFKNRELQIMR+L H NIV+L +FFYS+GEKKDE+YLNL+LE++PETVYRVARHY K +Q IP++++KLYMYQL+RSLAYIH++GICHRDIKPQNLL+DP++GVLKLCDFGSAK L R EPNVSYICSRYYRAPELIFGAT+YT  IDVWSAG V+AELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI  MNPNY EFKFP IKAHPWNKVFR  T  EAI+L++K++EYTP++R +P  +C H+FFDELR    +LP+ +PLP L
Sbjct:    6 LSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTL 339

HSP 2 Score: 63.929 bits (154), Expect = 1.981e-10
Identity = 44/160 (27.50%), Postives = 80/160 (50.00%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  NHP IV    F+      KD     + +E++ E   R    Y  +   +P+  ++ +  Q+L  L+Y+HS  I H D+K  N+L+  ++  +K+  F  +K++     +  +  ++CSR     + APE++      T S D+WS G ++ EL+ G+
Sbjct:   82 RKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYL---VRNEPNVSYICSR----YYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQ 234

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: C44H4.6 (pep chromosome:WBcel235:X:14596476:14599158:-1 gene:WBGene00008095.1 transcript:C44H4.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C44H4.6)

HSP 1 Score: 300.442 bits (768), Expect = 5.816e-94
Identity = 151/349 (43.27%), Postives = 211/349 (60.46%), Query Frame = 3

Query:  162 EGMRITTVTATPGQGEKTQ---EISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIP 1199
            E +   TV A  G G K     EI +T+ ++IG GSFG VY+A   E+ E +AIKK+  D RFK+REL IM ++ H NI+ LL+++    E      LN V+EF+P+ +  V R +  N + +P   IKLYM+QL+R + ++H   I HRDIKP+NLLVD   G+LK+CDFGSAK L++ EPN++YICSRYYRAPELIFG+ +Y   ID WS G V+ ELL   PIF  DS VD L   IK  GTPS+E + + N  Y    +  I      K    +     +EL+  L++  P  R+ P E+ T  +FD+LR    KLP+  P+PPLF++   E  +  +++  + P
Sbjct:   12 EHVTFHTVMAKRGTGSKLDREVEIQFTNLQLIGTGSFGAVYKAVLRENDEPIAIKKIKVDDRFKSRELTIMHEMDHPNIIRLLYYYVMQQEN----CLNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRGIGFLHLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPNITYICSRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLADSAVDILALQIKAFGTPSKEDMAKWNYEYVHIPYDTITGVGIQKFIGRKLSLSTLELLNSLMKMDPKLRIKPYEALTLPYFDDLRDPHYKLPSGAPIPPLFDWLEREYIANHEIIKDIFP 356

HSP 2 Score: 61.2326 bits (147), Expect = 1.584e-9
Identity = 42/150 (28.00%), Postives = 75/150 (50.00%), Query Frame = 3

Query: 1869 NHPTIVNFLAFY--KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIELV 2297
            +HP I+  L +Y  +  +     MEFM +      R +      +P   I+ +  Q+L G+ +LH + I+H D+K  N+L+ ++  I KI  F  +K +     +     ++CSR     + APE++   +N  T  D WS+G ++ EL+
Sbjct:   86 DHPNIIRLLYYYVMQQENCLNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRGIGFLHLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPNIT---YICSR----YYRAPELIFGSKNYDTSIDTWSVGTVVGELL 228

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: mpk-2 (Mitogen-activated protein kinase [Source:UniProtKB/TrEMBL;Acc:Q6ABN8])

HSP 1 Score: 176.022 bits (445), Expect = 1.247e-47
Identity = 100/302 (33.11%), Postives = 170/302 (56.29%), Query Frame = 3

Query:  246 IGNGSFGVVYQARFCESKELVAIKKV--------LQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQ-----RGEPNVS-----YICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAH---PWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDE 1088
            +G G++GVV +A    +K+ VAIKK+        L  R    RE++I+R+L H+NI+ +L  F + G    ++YL  V++ +   ++++      ++QT+     + + YQL+R L Y+H+ GI HRD+KP NLL++ D  +L++ DFG A+        R + NV      Y+ +R+YRAPE++F   +Y  ++D+WSAGC+ AE+LL + +FPG   V Q+  I+  LG+P  E I+++  +               P++ +F P+  PEA  +V+ LL+ +P  R S  +   H F  +
Sbjct:   63 VGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSL--REVRILRELLHENIIAVLDMFTAEGAHGKDIYL--VMDLMETDLHQILH----SRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDC-LLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDLVRDSIEACGRKTPLPFSAIF-PKASPEARNMVSYLLQISPWKRYSADQILQHPFMAQ 354

HSP 2 Score: 65.4698 bits (158), Expect = 7.734e-11
Identity = 45/150 (30.00%), Postives = 73/150 (48.67%), Query Frame = 3

Query: 1872 HPTIVNFLAFYKDNSS----FYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDK---GFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELV 2297
            H  I+  L  +    +     Y+ M+ M E  L   L     +  +  + +  Q+L GL YLHS  IIH DLK SN+LL+ +  ++I+ F +++  + A++   D    G +     T  + APE+L       TK D+WS G I  E++
Sbjct:  113 HENIIAVLDMFTAEGAHGKDIYLVMDLM-ETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEML 261

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: mpk-2 (Mitogen-activated protein kinase [Source:UniProtKB/TrEMBL;Acc:Q6ABN8])

HSP 1 Score: 175.637 bits (444), Expect = 2.463e-46
Identity = 100/300 (33.33%), Postives = 169/300 (56.33%), Query Frame = 3

Query:  246 IGNGSFGVVYQARFCESKELVAIKKV--------LQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQ-----RGEPNVS-----YICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAH---PWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            +G G++GVV +A    +K+ VAIKK+        L  R    RE++I+R+L H+NI+ +L  F + G    ++YL  V++ +   ++++      ++QT+     + + YQL+R L Y+H+ GI HRD+KP NLL++ D  +L++ DFG A+        R + NV      Y+ +R+YRAPE++F   +Y  ++D+WSAGC+ AE+LL + +FPG   V Q+  I+  LG+P  E I+++  +               P++ +F P+  PEA  +V+ LL+ +P  R S  +   H F 
Sbjct:   28 VGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSL--REVRILRELLHENIIAVLDMFTAEGAHGKDIYL--VMDLMETDLHQILH----SRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDC-LLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDLVRDSIEACGRKTPLPFSAIF-PKASPEARNMVSYLLQISPWKRYSADQILQHPFM 317

HSP 2 Score: 65.0846 bits (157), Expect = 1.578e-10
Identity = 44/140 (31.43%), Postives = 69/140 (49.29%), Query Frame = 3

Query: 1890 FLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDK---GFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELV 2297
            F A        Y+ M+ M E  L   L     +  +  + +  Q+L GL YLHS  IIH DLK SN+LL+ +  ++I+ F +++  + A++   D    G +     T  + APE+L       TK D+WS G I  E++
Sbjct:   88 FTAEGAHGKDIYLVMDLM-ETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEML 226

[Close]

Query:  246 IGNGSFGVVYQARFCESKELVAIKKV--------LQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQ-----RGEPNVS-----YICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAH---PWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            +G G++GVV +A    +K+ VAIKK+        L  R    RE++I+R+L H+NI+ +L  F + G    ++YL  V++ +   ++++      ++QT+     + + YQL+R L Y+H+ GI HRD+KP NLL++ D  +L++ DFG A+        R + NV      Y+ +R+YRAPE++F   +Y  ++D+WSAGC+ AE+LL + +FPG   V Q+  I+  LG+P  E I+++  +               P++ +F P+  PEA  +V+ LL+ +P  R S  +   H F 
Sbjct:   28 VGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSL--REVRILRELLHENIIAVLDMFTAEGAHGKDIYL--VMDLMETDLHQILH----SRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDC-LLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDLVRDSIEACGRKTPLPFSAIF-PKASPEARNMVSYLLQISPWKRYSADQILQHPFM 317

HSP 2 Score: 65.0846 bits (157), Expect = 1.578e-10
Identity = 44/140 (31.43%), Postives = 69/140 (49.29%), Query Frame = 3

Query: 1890 FLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDK---GFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELV 2297
            F A        Y+ M+ M E  L   L     +  +  + +  Q+L GL YLHS  IIH DLK SN+LL+ +  ++I+ F +++  + A++   D    G +     T  + APE+L       TK D+WS G I  E++
Sbjct:   88 FTAEGAHGKDIYLVMDLM-ETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILFSMVEYDTKVDLWSAGCIFAEML 226

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070469)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 271/386 (70.21%), Postives = 325/386 (84.20%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSI--EKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST-KLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            MS   ++ +  +GNK S S+    +K  +++G +ITTV ATPGQG ++ QE+SYTDTK+IGNGSFGVV+QA+ C++ ELVAIKKVLQDRRFKNRELQIMR+L+H NIV+LL+FFYS+GEK+DEV+LNLVLE+IPETVY+VAR Y K KQTIP+ FI+LYMYQL RSLAYIH+LGICHRDIKPQNLL+DP+T VLKLCDFGSAK L  GEPNVSYICSRYYRAPELIFGA +YT +IDVWSAGCVLAELLLGQPIFPGDSGVDQLVE+IKVLGTP+REQI +MNPNYTEFKFP IK+HPW KVFR RT  EAI LV+ LLEYTPS R++P+++C H FFDELR E    LPN + +PPLFNF  +E+  +  L+P L+P ++  + G
Sbjct:    1 MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASG 386

HSP 2 Score: 66.6254 bits (161), Expect = 5.542e-11
Identity = 47/161 (29.19%), Postives = 78/161 (48.45%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      +D     + +E++ E      R Y      +P+  IR +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++    N +TK D+WS G +L EL+ G+
Sbjct:  100 RKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVS----YICSR----YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQ 252

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070472)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 271/386 (70.21%), Postives = 325/386 (84.20%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSI--EKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST-KLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            MS   ++ +  +GNK S S+    +K  +++G +ITTV ATPGQG ++ QE+SYTDTK+IGNGSFGVV+QA+ C++ ELVAIKKVLQDRRFKNRELQIMR+L+H NIV+LL+FFYS+GEK+DEV+LNLVLE+IPETVY+VAR Y K KQTIP+ FI+LYMYQL RSLAYIH+LGICHRDIKPQNLL+DP+T VLKLCDFGSAK L  GEPNVSYICSRYYRAPELIFGA +YT +IDVWSAGCVLAELLLGQPIFPGDSGVDQLVE+IKVLGTP+REQI +MNPNYTEFKFP IK+HPW KVFR RT  EAI LV+ LLEYTPS R++P+++C H FFDELR E    LPN + +PPLFNF  +E+  +  L+P L+P ++  + G
Sbjct:    1 MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASG 386

HSP 2 Score: 66.6254 bits (161), Expect = 5.542e-11
Identity = 47/161 (29.19%), Postives = 78/161 (48.45%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      +D     + +E++ E      R Y      +P+  IR +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++    N +TK D+WS G +L EL+ G+
Sbjct:  100 RKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVS----YICSR----YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQ 252

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070473)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 271/386 (70.21%), Postives = 325/386 (84.20%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSI--EKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST-KLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            MS   ++ +  +GNK S S+    +K  +++G +ITTV ATPGQG ++ QE+SYTDTK+IGNGSFGVV+QA+ C++ ELVAIKKVLQDRRFKNRELQIMR+L+H NIV+LL+FFYS+GEK+DEV+LNLVLE+IPETVY+VAR Y K KQTIP+ FI+LYMYQL RSLAYIH+LGICHRDIKPQNLL+DP+T VLKLCDFGSAK L  GEPNVSYICSRYYRAPELIFGA +YT +IDVWSAGCVLAELLLGQPIFPGDSGVDQLVE+IKVLGTP+REQI +MNPNYTEFKFP IK+HPW KVFR RT  EAI LV+ LLEYTPS R++P+++C H FFDELR E    LPN + +PPLFNF  +E+  +  L+P L+P ++  + G
Sbjct:    1 MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASG 386

HSP 2 Score: 66.6254 bits (161), Expect = 5.542e-11
Identity = 47/161 (29.19%), Postives = 78/161 (48.45%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      +D     + +E++ E      R Y      +P+  IR +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++    N +TK D+WS G +L EL+ G+
Sbjct:  100 RKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVS----YICSR----YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQ 252

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070474)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 271/386 (70.21%), Postives = 325/386 (84.20%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSI--EKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST-KLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            MS   ++ +  +GNK S S+    +K  +++G +ITTV ATPGQG ++ QE+SYTDTK+IGNGSFGVV+QA+ C++ ELVAIKKVLQDRRFKNRELQIMR+L+H NIV+LL+FFYS+GEK+DEV+LNLVLE+IPETVY+VAR Y K KQTIP+ FI+LYMYQL RSLAYIH+LGICHRDIKPQNLL+DP+T VLKLCDFGSAK L  GEPNVSYICSRYYRAPELIFGA +YT +IDVWSAGCVLAELLLGQPIFPGDSGVDQLVE+IKVLGTP+REQI +MNPNYTEFKFP IK+HPW KVFR RT  EAI LV+ LLEYTPS R++P+++C H FFDELR E    LPN + +PPLFNF  +E+  +  L+P L+P ++  + G
Sbjct:    1 MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASG 386

HSP 2 Score: 66.6254 bits (161), Expect = 6.983e-11
Identity = 47/161 (29.19%), Postives = 78/161 (48.45%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      +D     + +E++ E      R Y      +P+  IR +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++    N +TK D+WS G +L EL+ G+
Sbjct:  100 RKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVS----YICSR----YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQ 252

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070468)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 271/386 (70.21%), Postives = 325/386 (84.20%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSI--EKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST-KLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            MS   ++ +  +GNK S S+    +K  +++G +ITTV ATPGQG ++ QE+SYTDTK+IGNGSFGVV+QA+ C++ ELVAIKKVLQDRRFKNRELQIMR+L+H NIV+LL+FFYS+GEK+DEV+LNLVLE+IPETVY+VAR Y K KQTIP+ FI+LYMYQL RSLAYIH+LGICHRDIKPQNLL+DP+T VLKLCDFGSAK L  GEPNVSYICSRYYRAPELIFGA +YT +IDVWSAGCVLAELLLGQPIFPGDSGVDQLVE+IKVLGTP+REQI +MNPNYTEFKFP IK+HPW KVFR RT  EAI LV+ LLEYTPS R++P+++C H FFDELR E    LPN + +PPLFNF  +E+  +  L+P L+P ++  + G
Sbjct:    1 MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQNASG 386

HSP 2 Score: 66.6254 bits (161), Expect = 5.542e-11
Identity = 47/161 (29.19%), Postives = 78/161 (48.45%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSL---RDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      +D     + +E++ E      R Y      +P+  IR +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++    N +TK D+WS G +L EL+ G+
Sbjct:  100 RKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVS----YICSR----YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQ 252

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3ba (glycogen synthase kinase 3 beta, genome duplicate a [Source:ZFIN;Acc:ZDB-GENE-990714-4])

HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0
Identity = 272/367 (74.11%), Postives = 316/367 (86.10%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR+ + KLPN +  P LFNF + E+ S   L   LIPA+     G
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELREPNVKLPNGREKPSLFNFTTQELSSNPTLASILIPAHARNQAG 387

HSP 2 Score: 57.7658 bits (138), Expect = 3.960e-8
Identity = 44/161 (27.33%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3bb (glycogen synthase kinase 3 beta, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-090312-2])

HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0
Identity = 266/377 (70.56%), Postives = 318/377 (84.35%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KKDEVYLNLV++++PE VYRVARHY K KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C H+FFDELR+ + KLPN +  P LFNF + E+ +   L   LIPA+      +   S +A +
Sbjct:   21 SAFGNMKVSRDKDGSKVTTVAATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVMDYVPENVYRVARHYSKAKQNLPMVYVKLYMYQLFRSLAYIHSYGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHTFFDELREPNLKLPNGRERPVLFNFTTQELSNNPSLASVLIPAHAQNQAENSTQSASAAT 397

HSP 2 Score: 57.7658 bits (138), Expect = 3.166e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + M+++ E      R Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S DIWS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGDKKDEVYLNLVMDYVPENVYRVARHYSKAKQNLPMVYVKLYMYQLFRSLAYIHSYGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDIWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3ab (glycogen synthase kinase 3 alpha b [Source:ZFIN;Acc:ZDB-GENE-990714-3])

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 267/370 (72.16%), Postives = 313/370 (84.59%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTAT 1250
            LK+    G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +S+E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+F+PETVYRVARH++K+K TIP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+E+C H+FFDELRQ + +LPN + LP LFNF+  E+  +  L   LIP +         + G+ +
Sbjct:   55 LKLGRDSG-KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDSQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKSKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAISLCSRLLEYTPVTRLSPLEACAHAFFDELRQPNARLPNGRELPQLFNFSPVELSIQPQLNSILIPPHARSQTTPASHEGSGS 423

HSP 2 Score: 57.3806 bits (137), Expect = 4.739e-8
Identity = 41/161 (25.47%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E   R    +      +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  129 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKSKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 281

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3aa (glycogen synthase kinase 3 alpha a [Source:ZFIN;Acc:ZDB-GENE-060503-796])

HSP 1 Score: 567 bits (1460), Expect = 0.000e+0
Identity = 266/374 (71.12%), Postives = 310/374 (82.89%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIP 1262
            LK++   G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  ++ E VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFY +GEKKDEVYLNLVL+++PETVYRVARH+ K K  IP+ ++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+++C H+FFDELRQ  T+LP+ + LPPLFNF + E+  +  L  TLIP +         N G+  S  P
Sbjct:   82 LKLARDSG-KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTHEWVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYCSGEKKDEVYLNLVLDYVPETVYRVARHFSKAKTIIPIFYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPPLFNFTTTELMIQPQLNSTLIPPHARAQTVASSNDGSEGSVQP 454

HSP 2 Score: 55.0694 bits (131), Expect = 2.676e-7
Identity = 37/144 (25.69%), Postives = 71/144 (49.31%), Query Frame = 3

Query: 1884 VNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            +N +  Y   + + VA  F K  ++         +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T + DIWS G +L EL+ G+
Sbjct:  182 LNLVLDYVPETVYRVARHFSKAKTI---------IPIFYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 308

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: zgc:171775 (zgc:171775 [Source:ZFIN;Acc:ZDB-GENE-030131-4309])

HSP 1 Score: 176.407 bits (446), Expect = 3.389e-48
Identity = 109/317 (34.38%), Postives = 171/317 (53.94%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKKV------LQDRRFKNRELQIMRQLKHQNIVELLFFFY--SNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEF---KFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFN 1145
            YT  K +G+G++G V  A   ++KE VAIKK+      L   +   REL+++R ++H N++ LL  F   S+ EK D  Y+  V+ F+ + +  + +        I  LF     YQ++R L YIH+ GI HRD+KP NL VD +   LK+ DFG A+  +       Y+ +R+YRAPE+IF    YT  +DVWSAGC+LAE++ G+ +FPG   +DQL +I+ + GTP+   + +M     +      P  K   + +VF     P AI+L+  +L   P  R+S     +H +  E        P ++P+ P ++
Sbjct:   25 YTSLKPVGSGAYGTVCFAVDQKTKEKVAIKKLYRPFQSLIHAKRAYRELRLLRHIQHDNVICLLNVFTPDSSLEKFDTFYM--VMPFVAQDLGHIMKRKQLTSNVITYLF-----YQILRGLKYIHSAGIIHRDLKPNNLAVDENCE-LKILDFGLARHTE--TEMTGYVVTRWYRAPEVIFNWMHYTQTVDVWSAGCILAEMITGEVLFPGSDSIDQLKKILNLTGTPNSTLVLKMQSKDAQSYVRSLPVQKKKAFKEVFS-GMDPNAIDLLEGMLVLDPEVRLSAKNGLSHPYLSEFHD-----PENEPVSPPYD 325

HSP 2 Score: 75.0998 bits (183), Expect = 6.943e-14
Identity = 53/167 (31.74%), Postives = 86/167 (51.50%), Query Frame = 3

Query: 1851 AYARLR-----NHPTIVNFLAFYKDNSS------FYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGEIPF 2315
            AY  LR      H  ++  L  +  +SS      FY+ M F+ +     +++K   +   +I     QIL GL Y+HS  IIH DLK +N+ + +N ++KI  F L++      +     G+V +R     + APEV+ +    T++ D+WS G IL E++TGE+ F
Sbjct:   69 AYRELRLLRHIQHDNVICLLNVFTPDSSLEKFDTFYMVMPFVAQD--LGHIMKRKQLTSNVITYLFYQILRGLKYIHSAGIIHRDLKPNNLAVDENCELKILDFGLARHTETEMT-----GYVVTR----WYRAPEVIFNWMHYTQTVDVWSAGCILAEMITGEVLF 224

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 575.089 bits (1481), Expect = 0.000e+0
Identity = 266/368 (72.28%), Postives = 314/368 (85.33%), Query Frame = 3

Query:  153 SNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
             +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFR RT PEAI L ++LLEYTP+ R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+ ++++  +     +TS
Sbjct:   36 GDKDGSKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH-ARNQASVPTPSNSTS 402

HSP 2 Score: 55.4546 bits (132), Expect = 2.792e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  108 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 260

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 266/366 (72.68%), Postives = 313/366 (85.52%), Query Frame = 3

Query:  159 KEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFR RT PEAI L ++LLEYTP+ R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+ ++++  +     +TS
Sbjct:   11 KDGSKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH-ARNQASVPTPSNSTS 375

HSP 2 Score: 55.4546 bits (132), Expect = 2.701e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:   81 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 233

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0
Identity = 270/386 (69.95%), Postives = 320/386 (82.90%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNK---------VFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            SS   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW K         VFR RT PEAI L ++LLEYTP+ R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+ ++++  +     +TS
Sbjct:   21 SSFGSMKVSRDKDGSKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVSSGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH-ARNQASVPTPSNSTS 405

HSP 2 Score: 55.8398 bits (133), Expect = 2.008e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNK---------VFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            SS   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW K         VFR RT PEAI L ++LLEYTP+ R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+ ++++  +     +TS
Sbjct:   21 SSFGSMKVSRDKDGSKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVSSGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH-ARNQASVPTPSNSTS 405

HSP 2 Score: 55.8398 bits (133), Expect = 1.969e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0
Identity = 264/363 (72.73%), Postives = 311/363 (85.67%), Query Frame = 3

Query:  168 MRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            +++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFR RT PEAI L ++LLEYTP+ R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+ ++++  +     +TS
Sbjct:   14 LKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH-ARNQASVPTPSNSTS 375

HSP 2 Score: 55.8398 bits (133), Expect = 1.874e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:   81 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 233

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 584.719 bits (1506), Expect = 0.000e+0
Identity = 271/361 (75.07%), Postives = 313/361 (86.70%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPH 381

HSP 2 Score: 58.9214 bits (141), Expect = 1.534e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 271/374 (72.46%), Postives = 313/374 (83.69%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNK-------------VFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW K             VFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSPGAGHFTPGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPH 394

HSP 2 Score: 58.9214 bits (141), Expect = 1.752e-8
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0
Identity = 264/358 (73.74%), Postives = 306/358 (85.47%), Query Frame = 3

Query:  156 NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFR-PRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
             ++  ++TTV AT GQG E++QE++YTD K+IGNGSFGVVYQAR  E++ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDE+YLNLVLE++PETVYRVARH+ K K   P+++IK+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+  +T PEAI L + LLEYTPS+R+SP+E+C HSFFDELR+   +LPND+PLPPLFNF+  E+  +  L   LIP ++    G
Sbjct:   94 GRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAG 451

HSP 2 Score: 56.9954 bits (136), Expect = 8.092e-8
Identity = 44/161 (27.33%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR--DYLVKTNPV-PVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + +E++ E   R   +  K   + P+  I+ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  165 RKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 317

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 566.229 bits (1458), Expect = 0.000e+0
Identity = 264/358 (73.74%), Postives = 306/358 (85.47%), Query Frame = 3

Query:  156 NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFR-PRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKG 1223
             ++  ++TTV AT GQG E++QE++YTD K+IGNGSFGVVYQAR  E++ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDE+YLNLVLE++PETVYRVARH+ K K   P+++IK+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+  +T PEAI L + LLEYTPS+R+SP+E+C HSFFDELR+   +LPND+PLPPLFNF+  E+  +  L   LIP ++    G
Sbjct:   94 GRDSGKVTTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPAG 451

HSP 2 Score: 56.9954 bits (136), Expect = 8.732e-8
Identity = 44/161 (27.33%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR--DYLVKTNPV-PVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + +E++ E   R   +  K   + P+  I+ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  165 RKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 317

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Cdk7 (cyclin-dependent kinase 7 [Source:MGI Symbol;Acc:MGI:102956])

HSP 1 Score: 181.03 bits (458), Expect = 4.845e-50
Identity = 113/306 (36.93%), Postives = 167/306 (54.58%), Query Frame = 3

Query:  210 KTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN---------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMN--PNYTEFK-FPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            K++   Y     +G G F  VY+AR   + ++VAIKK+    R +          RE++++++L H NI+ LL  F   G K +   ++LV +F+   +  + +    N   +    IK YM   ++ L Y+H   I HRD+KP NLL+D + GVLKL DFG AK    G PN +Y   + +R+YRAPEL+FGA  Y   +D+W+ GC+LAELLL  P  PGDS +DQL  I + LGTP+ EQ   M   P+Y  FK FP +   P   +F      + +EL+  L  + P TR +  ++    +F
Sbjct:    6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGV---PLQHIFIAAGD-DLLELIQGLFLFNPCTRTTASQALKTKYF 295

HSP 2 Score: 67.0106 bits (162), Expect = 2.745e-11
Identity = 46/152 (30.26%), Postives = 80/152 (52.63%), Query Frame = 3

Query: 1869 NHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPV--KLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNI-STKSDIWSLGAILIELVTGEIPF 2315
            +HP I+  L  +   S+  +  +FM+     + ++K N + +    I+ +    L+GL YLH + I+H DLK +N+LL +N  +K++ F L+K   G+ + A     V     T  + APE+L    +     D+W++G IL EL+   +PF
Sbjct:   70 SHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV-----TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212

[Close]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|P49841|GSK3B_HUMAN (Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2)

HSP 1 Score: 585.489 bits (1508), Expect = 0.000e+0
Identity = 274/378 (72.49%), Postives = 319/378 (84.39%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYIS-KSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +   ++      + TA S
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAAS 398

HSP 2 Score: 58.9214 bits (141), Expect = 1.102e-7
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q9WV60|GSK3B_MOUSE (Glycogen synthase kinase-3 beta OS=Mus musculus OX=10090 GN=Gsk3b PE=1 SV=2)

HSP 1 Score: 584.719 bits (1506), Expect = 0.000e+0
Identity = 271/361 (75.07%), Postives = 313/361 (86.70%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPH 381

HSP 2 Score: 58.9214 bits (141), Expect = 1.073e-7
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q5YJC2|GSK3B_SPECI (Glycogen synthase kinase-3 beta OS=Spermophilus citellus OX=9997 GN=GSK3B PE=2 SV=1)

HSP 1 Score: 583.948 bits (1504), Expect = 0.000e+0
Identity = 273/378 (72.22%), Postives = 318/378 (84.13%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYIS-KSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKD VYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +   ++      + TA S
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDVVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAAS 398

HSP 2 Score: 57.7658 bits (138), Expect = 3.034e-7
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDVVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|P18266|GSK3B_RAT (Glycogen synthase kinase-3 beta OS=Rattus norvegicus OX=10116 GN=Gsk3b PE=1 SV=1)

HSP 1 Score: 583.563 bits (1503), Expect = 0.000e+0
Identity = 270/361 (74.79%), Postives = 313/361 (86.70%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIP +
Sbjct:   21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPH 381

HSP 2 Score: 58.5362 bits (140), Expect = 1.675e-7
Identity = 45/161 (27.95%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +PV  ++ +  Q+   L+Y+HS  I H D+K  N+LL  D   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDMWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q91757|GSK3B_XENLA (Glycogen synthase kinase-3 beta OS=Xenopus laevis OX=8355 GN=gsk3b PE=1 SV=1)

HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0
Identity = 267/361 (73.96%), Postives = 313/361 (86.70%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            SS   +K+S +K+G ++TTV ATPGQG ++ QE++YTDTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARHY + KQ +P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFR RT PEAI L ++LLEYTP++R++P+++C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+
Sbjct:   21 SSFGSMKVSRDKDGSKVTTVVATPGQGPDRQQEVTYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPIIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTSRLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELSSNPSLSSILIPAH 381

HSP 2 Score: 56.6102 bits (135), Expect = 5.785e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPIIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: Q1WC09 (Glycogen synthase kinase 3 OS=Schmidtea mediterranea OX=79327 GN=GSK3.1 PE=2 SV=1)

HSP 1 Score: 880.167 bits (2273), Expect = 0.000e+0
Identity = 437/438 (99.77%), Postives = 437/438 (99.77%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPXXXXXXXXXXXXXDSHEDPEAVKPLH 1391
            MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEI YTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAVKPLH
Sbjct:    1 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEIFYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAVKPLH 438

[Close]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: Q589S2 (Glycogen synthase kinase 3 (Fragment) OS=Dugesia japonica OX=6161 GN=Dj0167HH PE=2 SV=1)

HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0
Identity = 378/400 (94.50%), Postives = 393/400 (98.25%), Query Frame = 3

Query:  114 GNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYI-SKSKGDIENSGTATSCIPFDNIKHMAS-STEISA 1307
            GNKASSSIEKLKISNKEGMR+TTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNG+KKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDP+TGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQ EAIELV+KLLEYTPSTRVSP+ESCTHSFF+ELRQESTKLPN+KPLPPLFNFASNEIGSRSDLLPTLIPAY+ SKSKGDI+ SGTA+SCIP+D+IK  A+ + EIS+
Sbjct:    2 GNKASSSIEKLKISNKEGMRVTTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGDKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPETGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQSEAIELVSKLLEYTPSTRVSPLESCTHSFFEELRQESTKLPNEKPLPPLFNFASNEIGSRSDLLPTLIPAYLSSKSKGDIDGSGTASSCIPYDSIKQSAAPNAEISS 401

[Close]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A0A172B139 (Glycogen synthase kinase 3-beta OS=Pinctada fucata OX=50426 GN=GSK PE=2 SV=1)

HSP 1 Score: 596.275 bits (1536), Expect = 0.000e+0
Identity = 278/394 (70.56%), Postives = 335/394 (85.03%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSIE--KLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYI--SKSKGDIENSGT 1244
            MS   ++ +  +G K  S+ +   ++ +N++G R+TTV AT G G ++ QE+SYTD K+IGNGSFGVVYQA+  ++ ELVAIKKVLQD+RFKNRELQIMR+L+H NIV+L +FFYS GEKKDEV+LNLVLE++PETVYRVARHY K+KQTIP+L+IKLYMYQL RSLAYIH++G+CHRDIKPQNLL+DP+TGVLKLCDFGSAKMLQ GEPNVSYICSRYYRAPELIFGATDYTC+IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNY+EFKFP IKAHPW KVFRPRT PEAI+LV++LLEYTPS R+SP+E+C H+FFDELR+ +T+LPN + LPPL+NF   E+         LIP +   + ++G   NSG+
Sbjct:    1 MSGRPRTTSFAEGGKQGSTAQFGGMRTTNRDGNRVTTVQATAGSGSDRPQEVSYTDAKVIGNGSFGVVYQAKLVDTNELVAIKKVLQDKRFKNRELQIMRKLEHVNIVKLKYFFYSAGEKKDEVFLNLVLEYVPETVYRVARHYSKSKQTIPMLYIKLYMYQLFRSLAYIHHVGVCHRDIKPQNLLLDPETGVLKLCDFGSAKMLQPGEPNVSYICSRYYRAPELIFGATDYTCRIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYSEFKFPQIKAHPWTKVFRPRTPPEAIQLVSRLLEYTPSARISPLEACAHTFFDELREPTTRLPNGRELPPLYNFTQQEMSILPSFNSKLIPPHARNAGNEGHPGNSGS 394

[Close]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A0A553NEJ9 (Protein kinase domain-containing protein OS=Tigriopus californicus OX=6832 GN=TCAL_00887 PE=3 SV=1)

HSP 1 Score: 596.275 bits (1536), Expect = 0.000e+0
Identity = 274/379 (72.30%), Postives = 331/379 (87.34%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSS-IEKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYI 1208
            MSN  ++ +  +G+KA+++    LKIS+K+G ++ TV A+PGQG +++ E+SYTDTK+IGNGSFGVVYQA+ CE+ E+VAIKKVLQD+RFKNRELQIMR+L+H NIV+L++FFY++GEKKDE+YLNLVLEFIPET+Y+VAR Y K+K TIP+ FIKLYMYQL RSLAYIH+ GICHRDIKPQNLL+DPD+G+LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCV AEL+LGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFR RT PEAI+LV++LLEYTPS R++P+++C H+FFDELR+  TKLPN + LPPLFNF  NE+  +  L   L+PA++
Sbjct:    1 MSNRPRTTSFVEGSKAANTNFGGLKISSKDGSKVMTVIASPGQGPDRSTEVSYTDTKVIGNGSFGVVYQAKLCETGEMVAIKKVLQDKRFKNRELQIMRRLEHCNIVKLMYFFYTSGEKKDEIYLNLVLEFIPETLYKVARQYSKSKHTIPVTFIKLYMYQLFRSLAYIHSQGICHRDIKPQNLLLDPDSGILKLCDFGSAKHLVRGEPNVSYICSRYYRAPELIFGATDYTTNIDVWSAGCVFAELMLGQPIFPGDSGVDQLVEIIKVLGTPTREQIKEMNPNYTEFKFPQIKAHPWQKVFRARTSPEAIDLVSRLLEYTPSARITPLQACAHTFFDELREPGTKLPNSRDLPPLFNFTENELKIQPSLNSQLVPAHL 379

HSP 2 Score: 65.855 bits (159), Expect = 2.707e-7
Identity = 48/167 (28.74%), Postives = 80/167 (47.90%), Query Frame = 3

Query: 1839 RKLFAYARLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEG---SLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R+L    RL  H  IV  + F+      KD     + +EF+ E      R Y    + +PV  I+ +  Q+   L+Y+HS  I H D+K  N+LL  D+  +K+  F  +K +     +     ++CSR     + APE++    + +T  D+WS G +  EL+ G+
Sbjct:   93 RELQIMRRLE-HCNIVKLMYFFYTSGEKKDEIYLNLVLEFIPETLYKVARQYSKSKHTIPVTFIKLYMYQLFRSLAYIHSQGICHRDIKPQNLLLDPDSGILKLCDFGSAKHLVRGEPNV---SYICSR----YYRAPELIFGATDYTTNIDVWSAGCVFAELMLGQ 251

[Close]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A0A1B1M0P2 (Glycogen synthase kinase-3 beta OS=Platynereis dumerilii OX=6359 PE=2 SV=1)

HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0
Identity = 282/385 (73.25%), Postives = 329/385 (85.45%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKA--SSSIEKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEK---KDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISK 1214
            MS   ++ +  +G K   SSS   +K  +K+G ++TTV ATPGQG ++ + +SYTDT++IGNGSFGVVYQAR CES ELVAIKKVLQD+RFKNRELQIMR+L+HQNIV+L +FFYS+GEK   KDEVYLNLVLE++PETVYR+AR Y K+KQTIP+L+IKLYMYQL RSLAYIH+ G+CHRDIKPQNLL+DPDTGVLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT QIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP I+AHPW KVFRPRT PEAI+LV++LLEYTPS R++P+E+C H FFDELR  ST+LP  K LPPLFNF S E+  +  +   LIP ++ +
Sbjct:    1 MSGRPRTTSFAEGAKQGQSSSFGGMKTISKDGSKVTTVMATPGQGVDRPEAVSYTDTRVIGNGSFGVVYQARLCESGELVAIKKVLQDKRFKNRELQIMRKLEHQNIVKLKYFFYSSGEKVSKKDEVYLNLVLEYVPETVYRMARQYSKSKQTIPILYIKLYMYQLFRSLAYIHSQGVCHRDIKPQNLLLDPDTGVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIRAHPWTKVFRPRTPPEAIDLVSQLLEYTPSRRIAPLEACAHGFFDELRDPSTRLPIGKELPPLFNFTSTELSIKPAMNGKLIPPHVQQ 385

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3ba (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:103021870])

HSP 1 Score: 583.178 bits (1502), Expect = 0.000e+0
Identity = 271/377 (71.88%), Postives = 319/377 (84.62%), Query Frame = 3

Query:  129 SSIEKLKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATS 1253
            S+   +K+S +K+G ++TTV ATPGQG ++ QE+SYTDTK+IGNGSFGVVYQA+ C+S E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KKDEVYLNLVL+++PETVYRVARHY + KQT+P++++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRPRT PEAI L ++LLEYTP+ R++P+E+C HSFFDELR  + KLPN +  P LFNF + E+ S   L   LIPA+     G    S  +++
Sbjct:   21 SAFGSMKVSRDKDGGKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNIKLPNGREKPSLFNFTTQELSSNPSLASILIPAHARNQAGASTPSNASST 397

HSP 2 Score: 55.8398 bits (133), Expect = 1.378e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E      R Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  102 RKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 254

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: ENSAMXT00000036323.1 (glycogen synthase kinase-3 beta-like [Source:NCBI gene;Acc:103043574])

HSP 1 Score: 577.4 bits (1487), Expect = 0.000e+0
Identity = 267/373 (71.58%), Postives = 315/373 (84.45%), Query Frame = 3

Query:  144 LKIS-NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSC 1256
            +K+S +K+G ++TTV ATPGQG ++ QE+SY DTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KKDEVYLNLVL+++PETVYRV+RHY + KQ +P+L++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRP+T PEAI L ++LLEYTP+ R +P+E+C H+FFDELR  + KLPN +  PPLFNF + E+ S   L   LIPA+     G    S  +++ 
Sbjct:   25 VKVSRDKDGSKVTTVGATPGQGPDRPQEVSYMDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPKTPPEAIALCSRLLEYTPTARFTPLEACAHAFFDELRVPTLKLPNGRERPPLFNFTTQELSSNPSLASILIPAHARNQAGASPPSNASSTA 397

HSP 2 Score: 54.6842 bits (130), Expect = 2.958e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:  101 RKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 253

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: ENSAMXT00000005621.2 (glycogen synthase kinase-3 beta-like [Source:NCBI gene;Acc:103043574])

HSP 1 Score: 576.63 bits (1485), Expect = 0.000e+0
Identity = 265/368 (72.01%), Postives = 311/368 (84.51%), Query Frame = 3

Query:  156 NKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSC 1256
            +K+G ++TTV ATPGQG ++ QE+SY DTK+IGNGSFGVVYQA+ C++ ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KKDEVYLNLVL+++PETVYRV+RHY + KQ +P+L++KLYMYQL RSLAYIH+ GICHRDIKPQNLL+DP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVFRP+T PEAI L ++LLEYTP+ R +P+E+C H+FFDELR  + KLPN +  PPLFNF + E+ S   L   LIPA+     G    S  +++ 
Sbjct:   13 DKDGSKVTTVGATPGQGPDRPQEVSYMDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPKTPPEAIALCSRLLEYTPTARFTPLEACAHAFFDELRVPTLKLPNGRERPPLFNFTTQELSSNPSLASILIPAHARNQAGASPPSNASSTA 380

HSP 2 Score: 54.6842 bits (130), Expect = 2.398e-7
Identity = 43/161 (26.71%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++++ E   R    Y      +P+  ++ +  Q+   L+Y+HS  I H D+K  N+LL  +   +K+  F  +K  + G  + +    ++CSR     + APE++      T S D+WS G +L EL+ G+
Sbjct:   84 RKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 236

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3aa (glycogen synthase kinase-3 alpha-like [Source:NCBI gene;Acc:103032471])

HSP 1 Score: 572.778 bits (1475), Expect = 0.000e+0
Identity = 267/367 (72.75%), Postives = 312/367 (85.01%), Query Frame = 3

Query:  108 NDGNKASSSIEKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
             D   +  S   LK+  + G  +TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +++ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+F+PETVYRVARH++K K  IP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+++C H+FFDELRQ  T+LP+ + LP LFNF + E+  +  L PTLIP +
Sbjct:   37 GDSQASGGSASNLKL-GRPGGEVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLIRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPQLFNFTTTELSIQPQLNPTLIPPH 402

HSP 2 Score: 55.4546 bits (132), Expect = 1.673e-7
Identity = 41/161 (25.47%), Postives = 77/161 (47.83%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E   R    +      +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  +   +K+  F  +K  I G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  123 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLIRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 275

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3ab (glycogen synthase kinase 3 alpha [Source:NCBI gene;Acc:103036469])

HSP 1 Score: 572.392 bits (1474), Expect = 0.000e+0
Identity = 270/380 (71.05%), Postives = 319/380 (83.95%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYI------SKSKGDIENSGTATSCIP 1262
            LK+S   G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +S+E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+++PETVYRVARH++K K TIP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDPDT VLKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+E+C H+FFDELRQ + +LP+ + LP LFNF+  E+  +  L  TLIP +       +  +G + +S   +S  P
Sbjct:   55 LKLSRDSG-KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDSQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAISLCSRLLEYTPVTRLSPLEACAHAFFDELRQPNARLPSGRELPMLFNFSPVELSIQPQLNSTLIPPHARSQTTSASHEGGVSDSPAQSSSAP 433

HSP 2 Score: 55.8398 bits (133), Expect = 1.345e-7
Identity = 41/159 (25.79%), Postives = 76/159 (47.80%), Query Frame = 3

Query: 1839 RKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  F  +  +     +N +  Y   + + VA  F K         KT  +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+  D   +K+  F  +K  + G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  140 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHFNK--------AKTT-IPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 281

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 184.496 bits (467), Expect = 1.470e-52
Identity = 112/296 (37.84%), Postives = 169/296 (57.09%), Query Frame = 3

Query:  246 IGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSR---EQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQ 1097
            IG G++GVVY+AR   + E VA+KK+  D   +       RE+ ++R+L H NIV LL   +S  EKK    L LV E + + + +   +       IPL  +K Y+YQL++ +A+ H+  I HRD+KPQNLL++ + G +KL DFG A+    G P  +Y   + + +YRAPE++ G   Y+  +DVWS GC+ AE+L  + +FPGDS +DQL  I + LGTP       + Q+ P+Y    FP        KV  P    E  +L+A +L+Y P+ RV+   + +H FF  ++Q
Sbjct:   10 IGEGTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLTIIHS--EKK----LYLVFELLDQDLKKFMDN--ATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAE-GAIKLADFGLARAF--GVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQL-PDYKS-TFPRWANQELTKVV-PTLNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNVKQ 291

HSP 2 Score: 78.9518 bits (193), Expect = 3.220e-16
Identity = 43/152 (28.29%), Postives = 81/152 (53.29%), Query Frame = 3

Query: 1869 NHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNP--VPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGEIPF 2315
            NHP IV  L         Y+  E + +  L+ ++    P  +P+ L++ +  Q+L+G+++ HS++I+H DLK  N+L++    IK++ F L++      +  + +        T  + APE+L+  ++ ST  D+WS+G I  E++T    F
Sbjct:   59 NHPNIVRLLTIIHSEKKLYLVFELLDQ-DLKKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAEGAIKLADFGLAR------AFGVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALF 203

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 179.104 bits (453), Expect = 1.127e-50
Identity = 109/296 (36.82%), Postives = 164/296 (55.41%), Query Frame = 3

Query:  246 IGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFK--FPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQE 1100
            IG G++GVVY+AR   + + VA+KK+  D   +       RE+ ++R+L H NIV LL   +S      E  L LV EF+ + + +   +      ++PL  +K YM+QL++ +A+ H     HRD+KPQNLL++ D G +KL DFG A+    G P  +Y   + + +YRAPE++ G   Y+  +DVWS GC+ AE+L  + +FPGDS +DQL  I + LGTP  E + Q      ++K  FP   A    KV  P       +L+ ++L+Y P+ RVS   +  H FF  L   
Sbjct:   10 IGEGTYGVVYKARHKMTGDTVALKKIRLDTETEGVPSTAIREIALLRELNHPNIVRLLDVIHS------ETKLYLVFEFLDQDLKKYMDNAPPLGISLPL--VKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINAD-GAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPD-ETVWQGITQLPDYKPSFPRWCAQDLTKVV-PLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLEHH 292

HSP 2 Score: 77.0258 bits (188), Expect = 1.556e-15
Identity = 45/158 (28.48%), Postives = 81/158 (51.27%), Query Frame = 3

Query: 1851 AYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKL--IRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGEIPF 2315
            A  R  NHP IV  L      +  Y+  EF+ +  L+ Y+    P+ + L  ++ +  Q+L+G+++ H+ + +H DLK  N+L++ +  IK++ F L++       +   +        T  + APE+L+  +  ST  D+WSLG I  E++T    F
Sbjct:   53 ALLRELNHPNIVRLLDVIHSETKLYLVFEFLDQ-DLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAIKLADFGLARAFGVPLRTYTHEVV------TLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALF 203

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: mapk12a (mitogen-activated protein kinase 12a [Source:NCBI gene;Acc:30681])

HSP 1 Score: 176.792 bits (447), Expect = 4.767e-49
Identity = 100/300 (33.33%), Postives = 168/300 (56.00%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKKV---LQDRRFKNR---ELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPN----YTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQ 1097
            Y+    +G+G++G V  +    +   VA+KK+    Q R F  R   EL++++ +KH+N++ L+  F  N          LV+ F+   + ++ +H  ++   +  L     +YQ+++ L YIH+ GI HRD+KP NL V+ D   LK+ DFG A+     +    Y+ +R+YRAPE+I     YT  +D+WS GC++AE++ G+P+FPG+  +DQL+ I+K+ GTP +  + +M+ N    Y +   P ++    + VF P   P AI+L+ K+L   P  R +  E+  H FF E R+
Sbjct:   27 YSQLFAVGSGAYGTVCSSMDLVTGSKVAVKKLYRPFQSRVFAKRAYRELRLLKHMKHENVIGLVDVFTPNDTLDQFQDFYLVMPFMGTDLSKIMKHGKQSDDKVQYL-----IYQILKGLKYIHSSGIIHRDLKPGNLAVNEDCE-LKILDFGLAR--HADQEMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKPLFPGNDHMDQLMLILKLTGTPPQYLVDRMDENEAAKYIK-TLPKMEKRRISTVF-PNANPIAIDLLEKMLALDPEQRPTASEALQHPFFSETRE 316

HSP 2 Score: 74.3294 bits (181), Expect = 2.233e-14
Identity = 52/176 (29.55%), Postives = 92/176 (52.27%), Query Frame = 3

Query: 1824 YKPLWRKLFA---YARLR-----NHPTIVNFLAFYKDNSS------FYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            Y+P   ++FA   Y  LR      H  ++  +  +  N +      FY+ M FM  G+    ++K        ++    QIL+GL Y+HS+ IIH DLK  N+ ++++ ++KI  F L++      +     G+V +R     + APEV+++    T++ DIWS+G I+ E++TG+
Sbjct:   59 YRPFQSRVFAKRAYRELRLLKHMKHENVIGLVDVFTPNDTLDQFQDFYLVMPFM--GTDLSKIMKHGKQSDDKVQYLIYQILKGLKYIHSSGIIHRDLKPGNLAVNEDCELKILDFGLARHADQEMT-----GYVVTR----WYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGK 223

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: mak (male germ cell-associated kinase [Source:ZFIN;Acc:ZDB-GENE-030131-7279])

HSP 1 Score: 176.792 bits (447), Expect = 6.745e-47
Identity = 103/295 (34.92%), Postives = 171/295 (57.97%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQ-----DRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLL-VDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSRE---QIHQMNPNYTEFKFPHIKAHPWN-KVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            YT  K +G+G++G V   R  E+ ELVAIKK+ +     D     RE++ +++L H N+++L      N    D +Y   V E++ E +Y++ +  +K     P   I+  MYQ+++ LA+IH  G  HRD+KP+NLL + P+  ++K+ DFG A+ ++   P   Y+ +R+YR PE++  +T Y+  ID+W+ GC++AEL   +P+FPG S VDQ+ +I +VLGTP +    + HQ+      F++P  +  P N K   P    EAI L+  +L + P  R + ++S  + +F
Sbjct:    4 YTTIKQLGDGTYGSVLMGRSNETGELVAIKKMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIREN----DCLYF--VFEYMKENLYQLMKDRNK---LFPESMIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPE--LVKIADFGLAREIRSRPPYTDYVSTRWYRGPEVLLRSTSYSSPIDIWALGCIMAELYTLRPLFPGSSEVDQIFKICQVLGTPKKNDWPEGHQLA-AAMNFRWP--QCVPTNLKTLIPNASNEAIHLMRDMLHWEPKKRPNAVQSLRYPYF 284

HSP 2 Score: 71.633 bits (174), Expect = 3.913e-13
Identity = 61/225 (27.11%), Postives = 106/225 (47.11%), Query Frame = 3

Query: 1794 IKKYERVEFSYKPLW--RKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNI----STNKKIPYSAPERIPKELNDFIAQCLIADVET 2447
            IKK +R  +S+      R++ +  +L NH  ++      ++N   Y   E+MKE   +    +    P  +IR    QIL+GL+++H +   H D+K  N+L    + +KI+ F L++ I    S      +V +R     +  PEVL+   + S+  DIW+LG I+ EL T    F   + +  I  I     T KK  +    ++   +N    QC+  +++T
Sbjct:   32 IKKMKRKFYSWDECMNLREVKSLKKL-NHANVIKLKEVIRENDCLYFVFEYMKENLYQLMKDRNKLFPESMIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLAREIR---SRPPYTDYVSTR----WYRGPEVLLRSTSYSSPIDIWALGCIMAELYTLRPLFPGSSEVDQIFKICQVLGTPKKNDWPEGHQLAAAMNFRWPQCVPTNLKT 248

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: cdk7 (cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GENE-010320-2])

HSP 1 Score: 170.244 bits (430), Expect = 7.812e-47
Identity = 106/300 (35.33%), Postives = 164/300 (54.67%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN---------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMN--PNYTEFK-FPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            Y     +G G F  VY+A    + ++VAIKK+    R +          RE++++++L H NI+ LL  F   G K +   ++LV +F+   +  + +        +    IK +M   ++ L Y+H   I HRD+KP NLL+D + GVLKL DFG AK    G P+  Y   + +R+YR+PEL+FGA  Y   +D+W+ GC+LAELLL  P  PGDS +DQL +I + LGTP+ E    M   P+Y E+K FP     P   +F   T  + +EL+  L  ++P+ R++  ++    +F
Sbjct:   26 YDKIDFLGEGQFATVYKAMDKVTNKIVAIKKIKLGHRTEAKDGINRTALREIKLLQELNHPNIIGLLDAF---GHKSN---ISLVFDFMDTDLEVIVK---DTSLVLSPANIKSFMVMTLQGLEYLHMHWILHRDMKPNNLLLD-EQGVLKLADFGLAKSF--GSPSRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRTPFLPGDSDLDQLSKIFEALGTPTEELWPGMTNLPDYVEYKSFP---GTPLENIFTAATD-DLLELLQGLFTFSPAARLTATQAMQMPYF 309

HSP 2 Score: 63.1586 bits (152), Expect = 8.227e-11
Identity = 43/147 (29.25%), Postives = 76/147 (51.70%), Query Frame = 3

Query: 1869 NHPTIVNFLAFYKDNSSFYVAMEFMK---EGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNI-STKSDIWSLGAILIELV 2297
            NHP I+  L  +   S+  +  +FM    E  ++D  +  +P  +K    +    L+GL YLH + I+H D+K +N+LL +   +K++ F L+K  S  + S +    V +R     + +PE+L    +     D+W++G IL EL+
Sbjct:   84 NHPNIIGLLDAFGHKSNISLVFDFMDTDLEVIVKDTSLVLSPANIK---SFMVMTLQGLEYLHMHWILHRDMKPNNLLLDEQGVLKLADFGLAK--SFGSPSRVYTHQVVTR----WYRSPELLFGARMYGVGVDMWAVGCILAELL 221

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: RIM11 (Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication [Source:SGD;Acc:S000004747])

HSP 1 Score: 364.77 bits (935), Expect = 3.465e-119
Identity = 177/321 (55.14%), Postives = 239/321 (74.45%), Query Frame = 3

Query:  219 EISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLG-ICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASN-EIGSRS 1175
            +IS+  T+++G+GSFGVV+     E+ E VAIKKVLQD+RFKNREL+IM+ L H NI++L +FFY   + +DE+YLNL+LE++P+++Y+  RH+   +  +  L IK YM+QL +SL Y+H+   +CHRDIKPQNLLVDP+T  LKLCDFGSAK L+  EPNVSYICSRYYRAPELIFGAT+YT QID+WS+GCV+AELLLGQP+FPG+SG+DQLVEIIK+LGTPS+++I  MNPNY E KFP IK  P ++VF+ +   + +E +A +L+Y P  R + ++     +FDEL+ +  K+        L  F  N E+G  S
Sbjct:   36 QISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYER-DSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFK-KEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFDENVELGHLS 354

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: MRK1 (Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication [Source:SGD;Acc:S000002237])

HSP 1 Score: 340.887 bits (873), Expect = 3.529e-108
Identity = 161/299 (53.85%), Postives = 223/299 (74.58%), Query Frame = 3

Query:  213 TQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNL-GICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQEST 1106
            T +ISY  T+++G+GSFGVV      E+ + VAIKKVLQDRR+KNREL+ M+ L H N V L ++FY   E+ DEVYLNLVL+++P+++Y+  RH+   K  +P + IK Y YQL ++L Y+HN+  ICHRDIKPQNLLVDP T   K+CDFGSAK L+  +PNVSYICSRYYRAPEL+FGAT+Y+ Q+DVWS+ CV+AELLLG+P+F G+SG+DQLVEIIK++G P++++I  MNPNY +  FP+IK     ++F+    P+ ++L+ K L+Y P  R+ P++    S+FDE ++  T
Sbjct:  159 TIDISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEE-DEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAE-DPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDT 455

HSP 2 Score: 48.9062 bits (115), Expect = 2.611e-6
Identity = 46/188 (24.47%), Postives = 85/188 (45.21%), Query Frame = 3

Query: 1872 HPTIVNFLAFY-----KDNSSFYVAMEFMKEG---SLRDYLVKTNPVPVKLIRKWARQILEGLSYLHS-NQIIHCDLKTSNILLSDNK-DIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELV------TGEIPFGKMAPLIVINNISTNKKIPYSAP 2384
            HP  V    ++     +D     + +++M +     LR ++     +P   I+ +A Q+ + L+YLH+  +I H D+K  N+L+       KI  F  +K +     +     ++CSR     + APE++    N S + D+WS   ++ EL+      +GE    ++  +I I  I T  +I    P
Sbjct:  214 HPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNV---SYICSR----YYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNP 394

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: MCK1 (Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication [Source:SGD;Acc:S000005251])

HSP 1 Score: 275.404 bits (703), Expect = 4.925e-85
Identity = 152/374 (40.64%), Postives = 216/374 (57.75%), Query Frame = 3

Query:  129 SSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKE----LVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTE--FKFPHIKAHPWNKV--FRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPND--KP--LPPLFNFASNEIGSRSDLLPTLIPAYISK 1214
            S+ E+  +  + G        T  +   T+ +   + + IG G+FG V QA   + K+      AIKKV     +K+RELQI+R   H NIV+L +FF     + ++VY +L +E +PET+      Y  NK  +PL  I+LY YQ+ R + Y+H LG+CHRDIKP N+LVDP+TGVLK+CDFGSAK L+  +P++SYICSR+YRAPELI G T YT QID+W  GCV+ E+L+G+ IF G   + QL EI K+LG P +  I   NP Y    F  P        +   +   + P+ I+L+ K+L Y P  R+SP     H FF+ELR + T LP    +P  LP LF+F   E+    +    + P  +++
Sbjct:    2 STEEQNGVPLQRGSEFIADDVTSNKSNNTRRMLVKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDDTFLPRGFTEPIKLPNLFDFNDFELQILGEFADKIKPTKVAE 375

HSP 2 Score: 76.2554 bits (186), Expect = 3.826e-15
Identity = 65/254 (25.59%), Postives = 114/254 (44.88%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY-----KDNSSF-YVAMEFMKEG---SLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNIST------NKKIPYSAP-----------------ERIPKELN-------DFIAQCLIADVETRWTVERLMGHEFLRD*R 2498
            R+ +HP IV    F+     +DN  + ++AME + E     +  Y+     +P+K IR +  QI  G+ YLH   + H D+K SN+L+     + KI  F  +K +     S     ++CSR     + APE++I     +T+ DIW LG ++ E++ G+  F    PL+ +  I+        + I +S P                 +R  K          D + + L+ + + R +  R++ H+F  + R
Sbjct:   85 RIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSI---SYICSR----FYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELR 331

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: YGK3 (Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005488])

HSP 1 Score: 228.794 bits (582), Expect = 7.331e-68
Identity = 127/337 (37.69%), Postives = 195/337 (57.86%), Query Frame = 3

Query:  234 DTKIIGNGSFGVVYQARFCE-SKELV---AIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYL---NLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQI---HQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKP----LPPLFNFASNEIGSRSDLLPTLIPA 1202
            + K IG+GSFG V Q+     S E +   AIK+V++  + ++ EL+I++ ++H N+V L FFF S+   KD  +L   N V+E+IP+T+      Y  N   +P   IKLY +Q++R+L  +H++ ICH D+KP N+L+ P +G+ K+CDFGSA+ L       +Y CSR+YRAPEL+  + DYT QID+WS GC++ E++ GQP+F GDS   QL EI K+LG   +  I    ++  +  + KF   K   W     P  +   +E + K+L Y  + R    +   H FFD LR E+  LP        LP LFNF+++E  +  +    ++P+
Sbjct:   43 EGKRIGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFK--KFMHW----FPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASEKRALGEYYNLIVPS 373

HSP 2 Score: 70.8626 bits (172), Expect = 2.469e-13
Identity = 67/242 (27.69%), Postives = 107/242 (44.21%), Query Frame = 3

Query: 1872 HPTIVNFLAFY------KDNSSFY---VAMEFMKE---GSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNIST-NKKIPYSA---PERIPKELND-------------------FIAQCLIADVETRWTVERLMGHEFL 2486
            HP +V    F+      KD    Y     ME++ +     + +Y    + +P K I+ +  QIL  L  LHS  I H DLK SNIL+  +  I K+  F  ++ +   T     K + CSR     + APE+L++ ++ +T+ DIWSLG I+ E++ G+  F   +    +  I+    + P S+    + +   LND                   F+ + L  D   R    +LM HEF 
Sbjct:   95 HPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTEL---KTYFCSR----FYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMHWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFF 329

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: CDC28 (Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant [Source:SGD;Acc:S000000364])

HSP 1 Score: 170.629 bits (431), Expect = 7.202e-48
Identity = 110/302 (36.42%), Postives = 167/302 (55.30%), Query Frame = 3

Query:  225 SYTDTKIIGNGSFGVVYQA---RFCESKELVAIKKVLQDRRFKN------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFK--FPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDE 1088
            +Y   + +G G++GVVY+A   R  + + +VA+KK+  +   +       RE+ ++++LK  NIV L    +S+  K     L LV EF+   + R      K+ Q +    +K +M QL + +AY H+  I HRD+KPQNLL++ D G LKL DFG A+    G P  +Y   I + +YRAPE++ G   Y+  +D WS GC+ AE+   +PIF GDS +DQ+ +I +VLGTP+ E I        +FK  FP  +    ++V  P   P  I+L+ KLL Y P  R+S   +  H +F E
Sbjct:    7 NYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHK-----LYLVFEFLDLDLKRYMEGIPKD-QPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKD-GNLKLGDFGLARAF--GVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPN-EAIWPDIVYLPDFKPSFPQWRRKDLSQVV-PSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE 297

HSP 2 Score: 66.2402 bits (160), Expect = 3.456e-12
Identity = 43/156 (27.56%), Postives = 81/156 (51.92%), Query Frame = 3

Query: 1839 RKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLV---KTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIEL 2294
            R++     L++   +  +   + D    Y+  EF+ +  L+ Y+    K  P+   +++K+  Q+ +G++Y HS++I+H DLK  N+L++ + ++K+  F L++   G    A     V     T  + APEVL+  +  ST  D WS+G I  E+
Sbjct:   57 REISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFL-DLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAF-GVPLRAYTHEIV-----TLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEM 205

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO36371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIW0])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 272/356 (76.40%), Postives = 309/356 (86.80%), Query Frame = 3

Query:  144 LKIS-NKEGMRITTVTATPGQ-GEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            +KIS +K+G +ITTV AT G   ++TQEISYTDTK+IGNGSFGVVYQAR C+S ELVAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+G+KK+E+YLNLVL+FIPETVYRVARHY K KQTIP+L+IKLYMYQL RSL YIH LGICHRDIKPQNLL+DP+T VLKLCDFGSAK+L +GEPNVSYICSRYYRAPELIFGATDY+  IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNP+YTEFKFP IK HPWNKVFRP+T PE+I L ++LLEYTPS R++ IESC H FFDELR  +TKLPN + LPPLFNF   E+  +  L   LIP +
Sbjct:   25 MKISRDKDGSKITTVVATTGSLPDRTQEISYTDTKVIGNGSFGVVYQARMCDSTELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRWFFYSSGDKKEEIYLNLVLDFIPETVYRVARHYSKAKQTIPMLYIKLYMYQLFRSLTYIHCLGICHRDIKPQNLLLDPETAVLKLCDFGSAKVLVKGEPNVSYICSRYYRAPELIFGATDYSPDIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIKEMNPHYTEFKFPQIKPHPWNKVFRPKTPPESINLCSRLLEYTPSGRLNAIESCAHCFFDELRDPNTKLPNGRDLPPLFNFTPQELSVKPALNTILIPPH 380

HSP 2 Score: 53.9138 bits (128), Expect = 1.977e-7
Identity = 41/160 (25.62%), Postives = 73/160 (45.62%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      K+     + ++F+ E   R    Y      +P+  I+ +  Q+   L+Y+H   I H D+K  N+LL  +   +K+  F  +K +     +     ++CSR     + APE++    + S   D+WS G +L EL+ G+
Sbjct:  101 RKLDHCNIVRLRWFFYSSGDKKEEIYLNLVLDFIPETVYRVARHYSKAKQTIPMLYIKLYMYQLFRSLTYIHCLGICHRDIKPQNLLLDPETAVLKLCDFGSAKVLVKGEPNV---SYICSR----YYRAPELIFGATDYSPDIDVWSAGCVLAELLLGQ 253

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO35402 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ0])

HSP 1 Score: 204.527 bits (519), Expect = 5.525e-59
Identity = 115/323 (35.60%), Postives = 184/323 (56.97%), Query Frame = 3

Query:  225 SYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQD------RRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQ--RGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PSREQIHQMNPNYTEFKFPHIK-AHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF----------DELRQESTKLPNDKPL 1130
             Y +  ++G GS+G+V + R  +S ++VAIKK ++       ++   RE++++RQL+H+N+V L+  F     +K  ++L  V EF+  TV      Y      +    ++  M+Q++R++ +IH   I HRD+KP+N+LV   +G++KLCDFG A+ L   +GE    Y+ +R+YRAPEL+ G T Y   +DVW+ GC+LAE+L G+P+FPGDS +DQL  I++  G       +I Q NP +   + P IK   P  + F PR  P A++++   L+  PS R +  +   H FF          +EL+ + TK   D PL
Sbjct:    3 KYENLGLVGEGSYGMVMKCRHKDSNQIVAIKKFIESEDDKMVKKIAMREVRMLRQLRHENLVNLIEVF----RRKKRLFL--VFEFVDHTVLDDLERY---PNGLDENTVRKVMWQVLRAIEFIHRHNIIHRDVKPENILVSR-SGIVKLCDFGFARTLASGQGEAYTDYVATRWYRAPELLVGDTKYGRAVDVWAVGCLLAEMLTGEPLFPGDSDIDQLYHIMRCFGNLISRHREIFQKNPLFVGMRLPDIKEVEPMERRF-PRISPMAVDMLKLCLKMDPSERPTCAQLLNHDFFKKDNFIEKFPNELKLKITKEAADNPL 314

HSP 2 Score: 77.0258 bits (188), Expect = 4.309e-15
Identity = 59/235 (25.11%), Postives = 106/235 (45.11%), Query Frame = 3

Query: 1872 HPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVI--------NNISTNKKI----PYSAPERIP--KELN--------------DFIAQCLIADVETRWTVERLMGHEFLR 2489
            H  +VN +  ++     ++  EF+    L D     N +    +RK   Q+L  + ++H + IIH D+K  NIL+S +  +K+  F  ++ ++     A    +V +R     + APE+L+ D       D+W++G +L E++TGE  F   + +  +        N IS +++I    P     R+P  KE+               D +  CL  D   R T  +L+ H+F +
Sbjct:   60 HENLVNLIEVFRRKKRLFLVFEFVDHTVLDDLERYPNGLDENTVRKVMWQVLRAIEFIHRHNIIHRDVKPENILVSRSGIVKLCDFGFARTLASGQGEAY-TDYVATRW----YRAPELLVGDTKYGRAVDVWAVGCLLAEMLTGEPLFPGDSDIDQLYHIMRCFGNLISRHREIFQKNPLFVGMRLPDIKEVEPMERRFPRISPMAVDMLKLCLKMDPSERPTCAQLLNHDFFK 289

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO40573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6R5])

HSP 1 Score: 179.874 bits (455), Expect = 1.121e-49
Identity = 106/307 (34.53%), Postives = 171/307 (55.70%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKK------VLQDRRFKNRELQIMRQLKHQNIVELLFFFYS--NGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKML-----QRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEF---KFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQE 1100
            Y   + IGNG++GVV  A    +   VA+KK      VL   R  +REL+I+R  KH NI+ +        N ++ D+VY+  VL+ +   ++R+        Q +    ++ ++YQ++R L YIH+  + HRD+KP NLLV+ +   LK+ DFG A+ L     ++      Y+ +R+YRAPEL+    +Y+  ID+WS GC+LAE++  +P+FPG + ++QL  I+ V GTPS+  I +M     +    + PH    P+ K F P+  PEAI L++++L+  P  R++   +  H F  E   E
Sbjct:   23 YKLIETIGNGAYGVVCSAMDTRTGAKVAVKKISRAFDVLTTARRTHRELKILRHFKHDNIICIRDILKPPVNLDEFDDVYV--VLDLMESDLHRIIH----TDQPLTTEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVN-ENAELKIGDFGMARGLCSSPLEQKRFMTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLNQLPHKDPVPFEKFF-PKAHPEAINLLSQMLQLDPKERITVENALQHPFLKEYHSE 321

HSP 2 Score: 82.8037 bits (203), Expect = 8.694e-17
Identity = 60/220 (27.27%), Postives = 105/220 (47.73%), Query Frame = 3

Query: 1923 YVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAID-KGFVCSRPGTCNFMAPEVLIDQN-ISTKSDIWSLGAILIELVT------GEIPFGKMAPLIVINNISTNKKIPYSAPERIPKELN----------------------DFIAQCLIADVETRWTVERLMGHEFLRD 2492
            YV ++ M E  L   +    P+  + +R +  QIL GL Y+HS +++H DLK SN+L+++N ++KI  F +++   G  SS ++ K F+     T  + APE+++  N  S   D+WS+G IL E++       G     ++  ++ +    +   I     ER+   LN                      + ++Q L  D + R TVE  + H FL++
Sbjct:  102 YVVLDLM-ESDLHRIIHTDQPLTTEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVNENAELKIGDFGMAR---GLCSSPLEQKRFMTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLNQLPHKDPVPFEKFFPKAHPEAINLLSQMLQLDPKERITVENALQHPFLKE 317

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0])

HSP 1 Score: 172.94 bits (437), Expect = 2.644e-48
Identity = 104/296 (35.14%), Postives = 166/296 (56.08%), Query Frame = 3

Query:  246 IGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSY---ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMN--PNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQE 1100
            IG G++GVVY+AR   +  +VA+KK+  D   +       RE+ ++++L H N+V LL   ++         L LV EF+ + + +       +  +  L  IK Y+YQL+  +AY H+  + HRD+KPQNLL+D + G +KL DFG A+    G P  SY   + + +YRAPE++ G+  Y   +DVWS GC+ AE+   + +FPGDS +DQL  I + LGTP  +    ++  P+Y +  FP         V  P     AI+L+ K+L Y P+ R+S   + +H FF +++++
Sbjct:   10 IGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQKS------LYLVFEFLSQDLKKYMDCLPPSGISTSL--IKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKN-GAIKLADFGLARAF--GVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDY-KTSFPKWPVQSIRHVL-PTLDNTAIDLLQKMLTYQPNARISAKAALSHEFFKDVQRK 292

HSP 2 Score: 78.1814 bits (191), Expect = 9.521e-16
Identity = 46/152 (30.26%), Postives = 79/152 (51.97%), Query Frame = 3

Query: 1869 NHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNP--VPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIELVTGEIPF 2315
            NHP +V+ L    +  S Y+  EF+ +  L+ Y+    P  +   LI+ +  Q+L G++Y HS++++H DLK  N+L+  N  IK++ F L++       S   +        T  + APE+L+  +  +T  D+WS+G I  E+ T    F
Sbjct:   59 NHPNVVSLLDVVHNQKSLYLVFEFLSQ-DLKKYMDCLPPSGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAFGVPVRSYTHEVV------TLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALF 203

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO49865 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7REX1])

HSP 1 Score: 174.096 bits (440), Expect = 3.980e-48
Identity = 105/296 (35.47%), Postives = 168/296 (56.76%), Query Frame = 3

Query:  228 YTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKN-------RELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKML-QRGEPNVSY-ICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMN--PNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFF 1082
            YT    IG G+ G+V++A+  ES E+VA+KKV   RR ++       RE++ +++ +    V  L   + +G         LV E++   +  V R+   +++ +    IK Y+  L++ +AY HN GI HRD+KP NLL+   TG LK+ DFG A++    GE   S+ + +R+YRAPEL++GA  Y   +D+W+ GC+  ELL   P+FPG++ ++QL  ++K LGTP+ E    M   P+Y +  FP + A P  K+  P   PEA++L+ + L Y    R+   E+  H +F
Sbjct:    7 YTILGRIGEGAHGIVFKAKHIESGEIVALKKV-PLRRLEDGIPNTALREIKSLQENEENPYVVKLIDVFPHGTG-----FVLVFEYMWSDLSEVLRN---SERPLTEAQIKGYLLMLLKGVAYCHNKGIMHRDLKPANLLIS-STGHLKIADFGLARVFSNEGERQYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNNSPLFPGENDIEQLCCVLKTLGTPNEEIWPGMTDLPDYNKITFPDMPAIPLEKIV-PDASPEAMDLLKRFLVYPSKKRIPASEALLHPYF 291

HSP 2 Score: 56.9954 bits (136), Expect = 1.609e-8
Identity = 35/144 (24.31%), Postives = 66/144 (45.83%), Query Frame = 3

Query: 1872 HPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVT 2300
            +P +V  +  +   + F +  E+M             P+    I+ +   +L+G++Y H+  I+H DLK +N+L+S    +KI+ F L++  S              +  T  + APE+L   +      D+W++G I  EL+ 
Sbjct:   64 NPYVVKLIDVFPHGTGFVLVFEYMWSDLSEVLRNSERPLTEAQIKGYLLMLLKGVAYCHNKGIMHRDLKPANLLISSTGHLKIADFGLARVFSNEGERQ-----YSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLN 202

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000027319.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 579.326 bits (1492), Expect = 0.000e+0
Identity = 271/391 (69.31%), Postives = 323/391 (82.61%), Query Frame = 3

Query:   81 SNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTAT 1250
            S+  K+     G  +S+S   LK+    G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +++E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYSNGEKKDEVYLNLVL+F+PETVYRVARH++K K TIP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T +LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+E+C H+FFDELRQ +T+LP+ + LP LFNF+S E+  +  L   LIP +         + G+ +
Sbjct:   34 SSTGKTGASQAGGSSSTSFGNLKLPRDSG-KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLNSALIPPHARAQTSPASHEGSVS 423

HSP 2 Score: 55.4546 bits (132), Expect = 1.859e-7
Identity = 41/161 (25.47%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E   R    +      +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+     I K+  F  +K  + G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  129 RKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 281

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000044063.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 578.556 bits (1490), Expect = 0.000e+0
Identity = 271/391 (69.31%), Postives = 323/391 (82.61%), Query Frame = 3

Query:   81 SNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTAT 1250
            S+  K+     G  +S+S   LK+    G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +++E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYSNGEKKDEVYLNLVL+F+PETVYRVARH++K K TIP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T +LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+E+C H+FFDELRQ +T+LP+ + LP LFNF+S E+  +  L   LIP +         + G+ +
Sbjct:   74 SSTGKTGASQAGGSSSTSFGNLKLPRDSG-KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLNSALIPPHARAQTSPASHEGSVS 463

HSP 2 Score: 55.8398 bits (133), Expect = 1.472e-7
Identity = 41/161 (25.47%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E   R    +      +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+     I K+  F  +K  + G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  169 RKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 321

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0
Identity = 261/355 (73.52%), Postives = 311/355 (87.61%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            LK++   G ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +++E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+F+PETVYRVARH++K K  IP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T +LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP++R+SP+E+C H+FFDELRQ +T+LP+ + LP LFNF++ E+  +  L   LIP +
Sbjct:   55 LKLARDSG-KVTTVVATPGQGPDRPQEVSYTDVKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSIQPQLNSILIPPH 408

HSP 2 Score: 54.6842 bits (130), Expect = 3.064e-7
Identity = 42/161 (26.09%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E      R +    + +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+     I K+  F  +K  + G  + +    ++CSR     + APE++      T + DIWS G +L EL+ G+
Sbjct:  129 RKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTANIDIWSAGCVLAELLLGQ 281

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000016710.2 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 565.074 bits (1455), Expect = 0.000e+0
Identity = 264/359 (73.54%), Postives = 313/359 (87.19%), Query Frame = 3

Query:  171 RITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGT 1244
            ++TTV ATPGQG ++ QE+SYTD K+IGNGSFGVVYQAR  +++E+VAIKKVLQD+RFKNRELQIMR+L H NIV L +FFYSNGEKKDEVYLNLVL+F+PETVYRVARH++K K TIP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T +LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP TR+SP+E+C H+FFDELRQ +T+LP+ + LP LFNF+S E+  +  L   LIP + ++++    + GT
Sbjct:   67 KVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQEMVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSIQPPLNSALIPPH-ARAQTSPASHGT 424

HSP 2 Score: 55.4546 bits (132), Expect = 1.895e-7
Identity = 41/161 (25.47%), Postives = 76/161 (47.20%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGSLR---DYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 2306
            R  +H  IV    F+      KD     + ++F+ E   R    +      +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+     I K+  F  +K  + G  + +    ++CSR     + APE++    + ++  DIWS G +L EL+ G+
Sbjct:  133 RKLDHCNIVRLRYFFYSNGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQ 285

[Close]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 494.582 bits (1272), Expect = 5.183e-168
Identity = 235/355 (66.20%), Postives = 279/355 (78.59%), Query Frame = 3

Query:  144 LKISNKEGMRITTVTATPGQG-EKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAY 1205
            LK++   G ++TTV ATPGQG ++ QE+SYTD K                                  NRELQIMR+L H NIV L +FFYS+GEKKDEVYLNLVL+F+PETVYRVARH++K K  IP++++K+YMYQL RSLAYIH+ G+CHRDIKPQNLLVDP+T +LKLCDFGSAK L RGEPNVSYICSRYYRAPELIFGATDYT  ID+WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP+REQI +MNPNYTEFKFP IKAHPW KVF+PRT PEAI L ++LLEYTP++R+SP+E+C H+FFDELRQ +T+LP+ + LP LFNF++ E+  +  L   LIP +
Sbjct:   55 LKLARDSG-KVTTVVATPGQGPDRPQEVSYTDVK----------------------------------NRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSIQPQLNSILIPPH 374

HSP 2 Score: 56.6102 bits (135), Expect = 7.219e-8
Identity = 45/176 (25.57%), Postives = 81/176 (46.02%), Query Frame = 3

Query: 1815 EFSYKPLWRKLFAYARLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKS-DIWSLGAILIELVTGE 2306
            E SY  +  +     R  +H  IV    F+      KD     + ++F+ E      R +    + +P+  ++ +  Q+   L+Y+HS  + H D+K  N+L+     I K+  F  +K  + G  + +    ++CSR     + APE++      T + DIWS G +L EL+ G+
Sbjct:   80 EVSYTDVKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVS----YICSR----YYRAPELIFGATDYTANIDIWSAGCVLAELLLGQ 247

[Close]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 883.248 bits (2281), Expect = 0.000e+0
Identity = 438/438 (100.00%), Postives = 438/438 (100.00%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPXXXXXXXXXXXXXDSHEDPEAVKPLH 1391
            MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAVKPLH
Sbjct:    1 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAVKPLH 438

HSP 2 Score: 59.6918 bits (143), Expect = 6.067e-9
Identity = 43/160 (26.88%), Postives = 76/160 (47.50%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      KD     + +EF+ E      R Y      +P+  I+ +  Q++  L+Y+H+  I H D+K  N+L+  D   +K+  F  +K +     +     ++CSR     + APE++    + + + D+WS G +L EL+ G+
Sbjct:   97 RQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNV---SYICSR----YYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQ 249

[Close]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 877.856 bits (2267), Expect = 0.000e+0
Identity = 434/434 (100.00%), Postives = 434/434 (100.00%), Query Frame = 3

Query:   78 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPXXXXXXXXXXXXXDSHEDPEAV 1379
            MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAV
Sbjct:    1 MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEISYTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIKHMASSTEISANPAGGLSAAGAVGSLDSHEDPEAV 434

HSP 2 Score: 59.6918 bits (143), Expect = 6.262e-9
Identity = 43/160 (26.88%), Postives = 76/160 (47.50%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLS-DNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLID-QNISTKSDIWSLGAILIELVTGE 2306
            R   H  IV  L F+      KD     + +EF+ E      R Y      +P+  I+ +  Q++  L+Y+H+  I H D+K  N+L+  D   +K+  F  +K +     +     ++CSR     + APE++    + + + D+WS G +L EL+ G+
Sbjct:   97 RQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNV---SYICSR----YYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQ 249

[Close]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000002706.1 (SMESG000002706.1)

HSP 1 Score: 485.723 bits (1249), Expect = 2.752e-164
Identity = 232/233 (99.57%), Postives = 233/233 (100.00%), Query Frame = 3

Query: 1794 IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAPERIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD 2492
            IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAP+RIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD
Sbjct:  195 IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAPKRIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD 427

HSP 2 Score: 61.2326 bits (147), Expect = 1.974e-9
Identity = 43/160 (26.88%), Postives = 76/160 (47.50%), Query Frame = 3

Query:  366 RQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNV---SYICSR----YYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQ 824
            R   H  IV  L F+      KD     + +EF+ E      R Y      +P+  I+ +  Q++  L+Y+H+  I H D+K  N+L+  D   +K+  F  +K +     +     ++CSR     + APE++    + + + D+WS G +L EL+ G+
Sbjct:  217 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILL-SDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 365

[Close]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000002706.1 (SMESG000002706.1)

HSP 1 Score: 486.108 bits (1250), Expect = 3.461e-164
Identity = 232/233 (99.57%), Postives = 233/233 (100.00%), Query Frame = 3

Query: 1794 IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAPERIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD 2492
            IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAP+RIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD
Sbjct:  219 IKKYERVEFSYKPLWRKLFAYARLRNHPTIVNFLAFYKDNSSFYVAMEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSAPKRIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD 451

HSP 2 Score: 61.2326 bits (147), Expect = 2.113e-9
Identity = 43/160 (26.88%), Postives = 76/160 (47.50%), Query Frame = 3

Query:  366 RQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNV---SYICSR----YYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQ 824
            R   H  IV  L F+      KD     + +EF+ E      R Y      +P+  I+ +  Q++  L+Y+H+  I H D+K  N+L+  D   +K+  F  +K +     +     ++CSR     + APE++    + + + D+WS G +L EL+ G+
Sbjct:  241 RLRNHPTIVNFLAFY------KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILL-SDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVLIDQ-NISTKSDIWSLGAILIELVTGE 389

[Close]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000012496.1 (SMESG000012496.1)

HSP 1 Score: 322.398 bits (825), Expect = 2.060e-103
Identity = 145/280 (51.79%), Postives = 204/280 (72.86%), Query Frame = 3

Query:  363 MRQLKHQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIGSRSDLLPTLIPA 1202
            M+ L+H N++ LL++F  NGEK D+ YLNL++E+IP+TVY + R Y +N+  IP  ++K++ YQ++R LAY+H   I HRDIKP NLLV+ +TG+LKLCDFGSAK+L  G+PNV+YICSR+YRAPELI G+ +YTC IDVWSAGCV+AE+LLG+ +F G + +DQLVEIIK++G+PS  QI +MN  Y EFK P +   P+ K+F  +  PE I L+  LLEY+P  R++ +ES  +++F+ELR+ S +LPN    P L +F+  E+  +  L   L P 
Sbjct:    1 MKMLQHPNVIALLYYFIHNGEK-DDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSLNHLLKPT 279

HSP 2 Score: 70.8626 bits (172), Expect = 4.412e-13
Identity = 44/164 (26.83%), Postives = 88/164 (53.66%), Query Frame = 3

Query: 1860 RLRNHPTIVNFLAFY-----KDNSSFYVAMEFMKEGS---LRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKTSNILLSDNKDI-KISGFNLSK-FISGATSSAIDKGFVCSRPGTCNFMAPEVLI-DQNISTKSDIWSLGAILIELVTGEIPFG 2318
            ++  HP ++  L ++     KD++   + ME++ +     +R Y      +P + ++ ++ Q+L GL+Y+H  QI+H D+K +N+L++    I K+  F  +K  +SG  + A    ++CSR     + APE+++   N +   D+WS G ++ E++ G   F 
Sbjct:    2 KMLQHPNVIALLYYFIHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVA----YICSR----FYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFS 157

The following BLAST results are available for this feature:

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
BLAST of glycogen synthase kinase 3 vs. TrEMBL
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST

BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GSK3B	2.294e-8	72.49	glycogen synthase kinase 3 beta [Source:HGNC Symbo...	[more]
GSK3B	2.934e-8	72.49	glycogen synthase kinase 3 beta [Source:HGNC Symbo...	[more]
GSK3A	1.021e-7	74.79	glycogen synthase kinase 3 alpha [Source:HGNC Symb...	[more]
GSK3A	1.021e-7	74.79	glycogen synthase kinase 3 alpha [Source:HGNC Symb...	[more]
GSK3B	2.808e-8	70.08	glycogen synthase kinase 3 beta [Source:HGNC Symbo...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk-3	2.240e-175	70.96	Glycogen synthase kinase-3 [Source:UniProtKB/Swis...	[more]
C44H4.6	5.816e-94	43.27	pep chromosome:WBcel235:X:14596476:14599158:-1 gen...	[more]
mpk-2	1.247e-47	33.11	Mitogen-activated protein kinase [Source:UniProtK...	[more]
mpk-2	2.463e-46	33.33	Mitogen-activated protein kinase [Source:UniProtK...	[more]
mpk-2	2.463e-46	33.33	Mitogen-activated protein kinase [Source:UniProtK...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sgg	5.542e-11	70.21	gene:FBgn0003371 transcript:FBtr0070469	[more]
sgg	5.542e-11	70.21	gene:FBgn0003371 transcript:FBtr0070472	[more]
sgg	5.542e-11	70.21	gene:FBgn0003371 transcript:FBtr0070473	[more]
sgg	6.983e-11	70.21	gene:FBgn0003371 transcript:FBtr0070474	[more]
sgg	5.542e-11	70.21	gene:FBgn0003371 transcript:FBtr0070468	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk3ba	3.960e-8	74.11	glycogen synthase kinase 3 beta, genome duplicate ...	[more]
gsk3bb	3.166e-8	70.56	glycogen synthase kinase 3 beta, genome duplicate ...	[more]
gsk3ab	4.739e-8	72.16	glycogen synthase kinase 3 alpha b [Source:ZFIN;Ac...	[more]
gsk3aa	2.676e-7	71.12	glycogen synthase kinase 3 alpha a [Source:ZFIN;Ac...	[more]
zgc:171775	3.389e-48	34.38	zgc:171775 [Source:ZFIN;Acc:ZDB-GENE-030131-4309]	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
GSK3B	2.792e-7	72.28	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	2.701e-7	72.68	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	2.008e-7	69.95	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	1.969e-7	69.95	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
GSK3B	1.874e-7	72.73	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Gsk3b	1.534e-8	75.07	glycogen synthase kinase 3 beta [Source:MGI Symbol...	[more]
Gsk3b	1.752e-8	72.46	glycogen synthase kinase 3 beta [Source:MGI Symbol...	[more]
Gsk3a	8.092e-8	73.74	glycogen synthase kinase 3 alpha [Source:MGI Symbo...	[more]
Gsk3a	8.732e-8	73.74	glycogen synthase kinase 3 alpha [Source:MGI Symbo...	[more]
Cdk7	4.845e-50	36.93	cyclin-dependent kinase 7 [Source:MGI Symbol;Acc:M...	[more]

BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P49841\|GSK3B_HUMAN	1.102e-7	72.49	Glycogen synthase kinase-3 beta OS=Homo sapiens OX...	[more]
sp\|Q9WV60\|GSK3B_MOUSE	1.073e-7	75.07	Glycogen synthase kinase-3 beta OS=Mus musculus OX...	[more]
sp\|Q5YJC2\|GSK3B_SPECI	3.034e-7	72.22	Glycogen synthase kinase-3 beta OS=Spermophilus ci...	[more]
sp\|P18266\|GSK3B_RAT	1.675e-7	74.79	Glycogen synthase kinase-3 beta OS=Rattus norvegic...	[more]
sp\|Q91757\|GSK3B_XENLA	5.785e-7	73.96	Glycogen synthase kinase-3 beta OS=Xenopus laevis ...	[more]

BLAST of glycogen synthase kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
Q1WC09	0.000e+0	99.77	Glycogen synthase kinase 3 OS=Schmidtea mediterran...	[more]
Q589S2	0.000e+0	94.50	Glycogen synthase kinase 3 (Fragment) OS=Dugesia j...	[more]
A0A172B139	0.000e+0	70.56	Glycogen synthase kinase 3-beta OS=Pinctada fucata...	[more]
A0A553NEJ9	2.707e-7	72.30	Protein kinase domain-containing protein OS=Tigrio...	[more]
A0A1B1M0P2	0.000e+0	73.25	Glycogen synthase kinase-3 beta OS=Platynereis dum...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gsk3ba	1.378e-7	71.88	glycogen synthase kinase 3 beta [Source:NCBI gene;...	[more]
ENSAMXT00000036323.1	2.958e-7	71.58	glycogen synthase kinase-3 beta-like [Source:NCBI ...	[more]
ENSAMXT00000005621.2	2.398e-7	72.01	glycogen synthase kinase-3 beta-like [Source:NCBI ...	[more]
gsk3aa	1.673e-7	72.75	glycogen synthase kinase-3 alpha-like [Source:NCBI...	[more]
gsk3ab	1.345e-7	71.05	glycogen synthase kinase 3 alpha [Source:NCBI gene...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cdk2	1.470e-52	37.84	cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN...	[more]
cdk2	1.127e-50	36.82	cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN...	[more]
mapk12a	4.767e-49	33.33	mitogen-activated protein kinase 12a [Source:NCBI ...	[more]
mak	6.745e-47	34.92	male germ cell-associated kinase [Source:ZFIN;Acc:...	[more]
cdk7	7.812e-47	35.33	cyclin-dependent kinase 7 [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
RIM11	3.465e-119	55.14	Protein kinase; required for signal transduction d...	[more]
MRK1	3.529e-108	53.85	Glycogen synthase kinase 3 (GSK-3) homolog; one of...	[more]
MCK1	4.925e-85	40.64	Dual-specificity ser/thr and tyrosine protein kina...	[more]
YGK3	7.331e-68	37.69	Protein kinase related to mammalian GSK-3 glycogen...	[more]
CDC28	7.202e-48	36.42	Cyclin-dependent kinase (CDK) catalytic subunit; m...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO36371	1.977e-7	76.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35402	5.525e-59	35.60	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40573	1.121e-49	34.53	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41403	2.644e-48	35.14	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49865	3.980e-48	35.47	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000027319.1	1.859e-7	69.31	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
ENSORLT00000044063.1	1.472e-7	69.31	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
gsk3aa	3.064e-7	73.52	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
ENSORLT00000016710.2	1.895e-7	73.54	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]
gsk3aa	5.183e-168	66.20	glycogen synthase kinase-3 beta [Source:NCBI gene;...	[more]

BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000023764.1	6.067e-9	100.00	SMESG000023764.1	[more]
SMESG000023764.1	6.262e-9	100.00	SMESG000023764.1	[more]
SMESG000002706.1	2.752e-164	99.57	SMESG000002706.1	[more]
SMESG000002706.1	3.461e-164	99.57	SMESG000002706.1	[more]
SMESG000012496.1	2.060e-103	51.79	SMESG000012496.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30021687
GenBank	ABD62975.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence
protein sequence

transcript sequence

>SMED30021687 ID=SMED30021687|Name=glycogen synthase kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=2642bp
GAAGTTTATTGTTTACATAATTATAGCGAAAATTAAAATTTTTAATTATA
TAAATTAATCATTATCAATGTTAAAAAATGAGTAATAATAAAAAATCTTT
AAATCAAAATGATGGCAATAAAGCTAGTAGTAGTATTGAAAAATTGAAAA
TTTCAAATAAAGAAGGTATGCGAATAACAACAGTAACTGCTACACCTGGT
CAGGGTGAAAAAACACAAGAAATTTCTTATACAGATACTAAAATAATTGG
CAATGGTTCTTTTGGTGTCGTTTATCAAGCTAGATTTTGTGAATCGAAAG
AACTTGTTGCAATTAAAAAAGTTTTACAAGATCGCAGATTTAAAAATCGT
GAGTTGCAGATTATGCGTCAATTAAAGCATCAAAATATTGTTGAATTATT
ATTCTTCTTTTATTCTAACGGAGAGAAGAAGGACGAAGTTTACTTGAATT
TGGTTTTGGAATTTATCCCAGAAACAGTTTATCGAGTGGCCAGACACTAT
CACAAGAACAAGCAAACAATCCCGCTTCTTTTTATCAAGCTTTATATGTA
CCAATTAATGAGAAGTCTTGCATATATTCATAACCTTGGGATTTGCCACA
GAGATATCAAACCTCAAAATCTGCTTGTCGACCCAGATACTGGAGTTTTA
AAACTGTGTGATTTTGGCAGTGCCAAAATGCTGCAGCGTGGTGAACCAAA
CGTTTCATACATCTGTTCCAGATATTACAGAGCTCCTGAATTGATATTTG
GAGCTACGGATTATACATGTCAAATAGATGTTTGGTCAGCCGGTTGTGTA
CTTGCTGAACTTCTTTTGGGTCAACCTATTTTCCCCGGCGACAGTGGAGT
AGACCAATTGGTAGAAATAATAAAAGTCTTGGGAACTCCAAGTCGAGAGC
AAATACATCAAATGAACCCAAATTATACGGAATTCAAGTTTCCGCATATC
AAAGCACATCCTTGGAACAAGGTATTTCGACCAAGAACACAACCTGAAGC
TATTGAGTTGGTCGCAAAGTTACTTGAATACACCCCATCAACAAGAGTGT
CGCCTATAGAATCCTGTACACATTCATTCTTTGATGAGCTTCGACAGGAA
TCAACCAAACTACCTAATGATAAACCATTACCTCCTTTGTTCAATTTTGC
TTCAAACGAAATTGGCAGCCGATCGGATCTGTTACCAACATTAATACCAG
CTTATATTAGTAAATCGAAAGGTGATATAGAGAATTCAGGAACAGCTACT
AGTTGCATTCCTTTTGATAACATCAAACATATGGCTTCTTCTACAGAAAT
CAGTGCTAATCCAGCAGGTGGATTGTCAGCCGCGGGAGCTGTAGGATCTT
TGGATTCCCATGAAGATCCTGAAGCAGTTAAACCTTTGCATTAGACTGTC
GATAAATAAACCTTTTAAATTTATATCCTTTTGAACTCTATCTAGGTCAC
TACTAATACCGCCACCACAATTTCCACCACCGCTGTCACCACCACCATCA
GCAGTCCTTAATAAATAACAGATATTTACAGAGAGAAATCAGTTCTTCAT
TTATCAATAAATTTCGACTATTTTATCTCTATGAAAAATTTATATAGAAG
AAACGTGTCATTATGATGTGTGAGCTAGAGCGATAGAGAGAGTACTAATA
AATCATCTAATTGTACAATTATCACAAGCGATTTTATGACGAAATATCCT
TTTCGAATGTGTATTATAATATTGAATTTTTAATTCGTCAGTCAAAACTT
ATTGTTTTTGAATAATAATAATAATAATAATTTGGTTCTTGTAATTAAAA
AATATGAGCGGGTTGAATTCTCTTACAAACCTCTGTGGAGGAAACTTTTT
GCATATGCTCGTTTAAGGAATCATCCGACAATTGTGAATTTCCTAGCTTT
TTATAAGGATAACTCATCATTTTATGTGGCAATGGAATTCATGAAAGAAG
GATCCCTCCGTGATTATTTAGTAAAAACCAATCCGGTTCCGGTCAAATTA
ATTCGTAAATGGGCTCGACAAATTTTAGAAGGTTTATCATATTTGCATTC
CAATCAAATCATTCATTGTGATTTGAAAACATCGAATATTTTACTCAGTG
ATAATAAGGACATAAAGATTTCTGGATTCAATTTGTCCAAGTTCATCTCG
GGCGCAACCTCATCAGCAATTGATAAAGGATTCGTGTGTTCTCGACCAGG
CACATGCAACTTCATGGCACCGGAAGTATTAATTGATCAAAACATCAGTA
CGAAATCAGATATTTGGTCACTTGGTGCTATTCTAATCGAGTTGGTAACA
GGCGAAATTCCATTTGGCAAAATGGCTCCTCTCATCGTCATTAACAATAT
TTCTACTAACAAGAAAATACCTTATTCGGCCCCCGAAAGAATTCCGAAAG
AATTAAACGATTTTATTGCACAATGTTTAATTGCAGATGTCGAAACGAGA
TGGACAGTAGAAAGGCTGATGGGACATGAATTTTTGCGTGACTGACGCAA
GTCTTGAGTTGGTAACATTTAATGAAAGATTGTTTGTTAGTATTTAATTT
TTTATTTACGAACTTTTTCTGCAAGTTGATTTTTGTTTCTTGAATTGTAA
TTTGGAAATTTATTAATAAACATTTTGGAAATCGGAAAAAAA

protein sequence of SMED30021687-orf-1

>SMED30021687-orf-1 ID=SMED30021687-orf-1|Name=SMED30021687-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=439bp
MSNNKKSLNQNDGNKASSSIEKLKISNKEGMRITTVTATPGQGEKTQEIS
YTDTKIIGNGSFGVVYQARFCESKELVAIKKVLQDRRFKNRELQIMRQLK
HQNIVELLFFFYSNGEKKDEVYLNLVLEFIPETVYRVARHYHKNKQTIPL
LFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAK
MLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQP
IFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVF
RPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKP
LPPLFNFASNEIGSRSDLLPTLIPAYISKSKGDIENSGTATSCIPFDNIK
HMASSTEISANPAGGLSAAGAVGSLDSHEDPEAVKPLH*

protein sequence of SMED30021687-orf-2

>SMED30021687-orf-2 ID=SMED30021687-orf-2|Name=SMED30021687-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=188bp
MEFMKEGSLRDYLVKTNPVPVKLIRKWARQILEGLSYLHSNQIIHCDLKT
SNILLSDNKDIKISGFNLSKFISGATSSAIDKGFVCSRPGTCNFMAPEVL
IDQNISTKSDIWSLGAILIELVTGEIPFGKMAPLIVINNISTNKKIPYSA
PERIPKELNDFIAQCLIADVETRWTVERLMGHEFLRD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000034	epidermis
PLANA:0000044	cephalic ganglia
PLANA:0000070	intestinal phagocyte
PLANA:0000097	ventral nerve cord
PLANA:0000103	central nervous system
PLANA:0002142	parenchyma
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR039192	STKc_GSK3
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf
IPR017441	Protein_kinase_ATP_BS

Vocabulary: **molecular function**
Term	Definition
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004674	protein serine/threonine kinase activity
GO:0016301	kinase activity

Vocabulary: **biological process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 51..335 e-value: 5.4E-83 score: 291.7
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 51..335 e-value: 3.5E-65 score: 220.0
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 51..335 score: 43.524
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 132..378 e-value: 3.5E-79 score: 267.6
None	No IPR available	GENE3D	G3DSA:3.30.200.20		coord: 36..131 e-value: 3.1E-38 score: 131.3
None	No IPR available	PANTHER	PTHR24057:SF14	GLYCOGEN SYNTHASE KINASE-3 ALPHA	coord: 16..389
None	No IPR available	PANTHER	PTHR24057	GLYCOGEN SYNTHASE KINASE-3 ALPHA	coord: 16..389
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 57..81
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 172..184
IPR039192	Glycogen synthase kinase 3, catalytic domain	CDD	cd14137	STKc_GSK3	coord: 46..338 e-value: 0.0 score: 609.889
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 50..366