Conserved uncharacterized CXorf65-related protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021615 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Match: A0A2B4SMC2 (Uncharacterized protein CXorf65-like OS=Stylophora pistillata OX=50429 GN=Gm614 PE=4 SV=1) HSP 1 Score: 78.1814 bits (191), Expect = 9.177e-15 Identity = 47/147 (31.97%), Postives = 79/147 (53.74%), Query Frame = 1 Query: 67 FVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANP----YLPLLDNESLVTPSFLEQLXXXXXXXXXXXXELA---KKSHLKPSFEIKEESNRRKLS 486 F+ V YG+ ++ + N +CR++ L++ +KR C EN + DL D+ G +KN+ + +G+E L+ RE ++V+V + Y PLLD+E ++T FLE L+R + ++ LKPS + K+ S R LS Sbjct: 2 FITVKYGDHREALFNPNCRIIHLLEDIKRRC----NCAENAVIDLSDLQGAVKNLTDHQASNGIEFLNERETFILVRVEKNIEGREFPLYTPLLDDEDVLTKDFLESLRRTPTDTLEVSGRGSRSMRRGSLKPSVKRKQSSGNRSLS 144
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Match: A7RXB3 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g203535 PE=4 SV=1) HSP 1 Score: 66.6254 bits (161), Expect = 1.988e-10 Identity = 39/107 (36.45%), Postives = 59/107 (55.14%), Query Frame = 1 Query: 67 FVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTN--DAANP-YLPLLDNESLVTPSFLEQL 378 F+ V YG ++ + N +CR++ L+D +KR C K TE +L DL DVNG ++N+ + + + L RE ++V+V P Y PLL + VT FLE L Sbjct: 2 FITVKYGEAEEALFNPNCRILHLLDDIKRRC----KCTEEVLVDLSDVNGSVQNLADNQSCNATDFLKGRETFILVRVEKIEGVERPIYTPLLRDSDYVTSEFLESL 104
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Match: V3ZYN8 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_204334 PE=4 SV=1) HSP 1 Score: 61.6178 bits (148), Expect = 1.190e-8 Identity = 33/108 (30.56%), Postives = 57/108 (52.78%), Query Frame = 1 Query: 64 TFVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTND---AANPYLPLLDNESLVTPSFLEQL 378 +F+ V YG+ ++ I N C L++Y++R C + + DLVD G ++N+ T++ E + RE ++V++ D +N Y+PLLDN P L +L Sbjct: 14 SFIRVKYGHDKEAIFNPWCSTYTLLEYIRRTC----DCDQEYVIDLVDQQGHVRNLSTGTEEYANELVSARETYVLVRIERDGEMGSNKYIPLLDNLDKFNPELLVKL 117
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Match: A0A2B4SYP5 (Uncharacterized protein CXorf65-like OS=Stylophora pistillata OX=50429 GN=Gm614 PE=4 SV=1) HSP 1 Score: 61.6178 bits (148), Expect = 1.863e-8 Identity = 40/123 (32.52%), Postives = 65/123 (52.85%), Query Frame = 1 Query: 67 FVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDA---ANPYLPLLDNESLVTPSFLEQLXXXXXXXXXXXXELAK 426 F+ V YG+ ++ I N +CR L++ +KR C T++ DL D +G +K + N E L RE L++++V + + Y P+L++ +VTP FLE+L R + K LAK Sbjct: 2 FITVRYGDGEESIFNPNCRTNILLEDIKRRC----NCTKDATVDLSDESGNLKYLANHPMSYATEILKERESLVLIRVEKKSEAEGDSYTPMLNDMIIVTPQFLERLSRCESDSLNAKNSLAK 120
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Match: A0A3M6UK83 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00013155 PE=4 SV=1) HSP 1 Score: 61.2326 bits (147), Expect = 2.403e-8 Identity = 42/140 (30.00%), Postives = 72/140 (51.43%), Query Frame = 1 Query: 88 NQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANP----YLPLLDNESLVTPSFLEQLXXXXXXXXXXXXELA---KKSHLKPSFEIKEESNRRKLS 486 N ++ + N +CR++ L++ +KR C EN + DL D+ G +KN+ + +G E L+ RE ++V+V + Y PLL++E ++T FLE L+R + ++ LKPS + K+ S LS Sbjct: 10 NHEEALFNPNCRILHLLEDIKRRC----NCAENAVIDLSDLQGAVKNLTDHQASNGSEFLNERETFILVRVEKNIEGREFPLYTPLLNDEDVLTKDFLESLRRTPTDTLEVSGRGSRSMRRGSLKPSVKRKQSSGNLSLS 145
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Nematostella
Match: EDO43935 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXB3]) HSP 1 Score: 66.6254 bits (161), Expect = 2.750e-14 Identity = 39/107 (36.45%), Postives = 59/107 (55.14%), Query Frame = 1 Query: 67 FVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTN--DAANP-YLPLLDNESLVTPSFLEQL 378 F+ V YG ++ + N +CR++ L+D +KR C K TE +L DL DVNG ++N+ + + + L RE ++V+V P Y PLL + VT FLE L Sbjct: 2 FITVKYGEAEEALFNPNCRILHLLDDIKRRC----KCTEEVLVDLSDVNGSVQNLADNQSCNATDFLKGRETFILVRVEKIEGVERPIYTPLLRDSDYVTSEFLESL 104
BLAST of Conserved uncharacterized CXorf65-related protein vs. Planmine SMEST
Match: SMESG000033459.1 (SMESG000033459.1) HSP 1 Score: 189.504 bits (480), Expect = 8.536e-63 Identity = 90/92 (97.83%), Postives = 91/92 (98.91%), Query Frame = 1 Query: 61 MTFVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPYLPLL 336 MTFVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPY+P L Sbjct: 1 MTFVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPYVPFL 92
BLAST of Conserved uncharacterized CXorf65-related protein vs. Planmine SMEST
Match: SMESG000033459.1 (SMESG000033459.1) HSP 1 Score: 136.732 bits (343), Expect = 3.052e-42 Identity = 65/67 (97.01%), Postives = 66/67 (98.51%), Query Frame = 1 Query: 136 MDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPYLPLL 336 MDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPY+P L Sbjct: 1 MDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPYVPFL 67
BLAST of Conserved uncharacterized CXorf65-related protein vs. Planmine SMEST
Match: SMESG000023661.1 (SMESG000023661.1) HSP 1 Score: 60.077 bits (144), Expect = 1.365e-11 Identity = 32/107 (29.91%), Postives = 57/107 (53.27%), Query Frame = 1 Query: 67 FVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVNGGIKNIRNITDQSGLEELHTREELLIVQVTNDAANPYL---PLLDNESLVTPSFLEQL 378 FV++H+G+ +K I N DC + +DY+++NCL I E+ +FD D+NG + I + +S + R + V + D N PL++ + + PS ++L Sbjct: 11 FVWIHHGDNKKFIANTDCSALNFLDYIRKNCL----IDESDIFDFTDINGKLLQISDQFHESWHTQFENRSIYIPVSIDKDDHNEICDVRPLIEGINELYPSLQDKL 113 The following BLAST results are available for this feature:
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Conserved uncharacterized CXorf65-related protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Conserved uncharacterized CXorf65-related protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021615 ID=SMED30021615|Name=Conserved uncharacterized CXorf65-related protein|organism=Schmidtea mediterranea sexual|type=transcript|length=565bpback to top protein sequence of SMED30021615-orf-1 >SMED30021615-orf-1 ID=SMED30021615-orf-1|Name=SMED30021615-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=149bp MTFVFVHYGNQQKMILNADCRLVCLMDYLKRNCLQNYKITENMLFDLVDVback to top Annotated Terms
The following terms have been associated with this transcript:
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