Cyclin-dependent kinase 2-associated protein 2

Overview


Name	Cyclin-dependent kinase 2-associated protein 2
Smed ID	SMED30021597
Length (bp)	219

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30021597

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30021597	SMESG000041391.1	SmedASXL_053139	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
nervous system	SMED30021597	SMESG000041391.1	dd_Smed_v4_552_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30021597	SMESG000041391.1	dd_Smed_v4_552_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30021597	SMESG000041391.1	dd_Smed_v4_552_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30021597	SMESG000041391.1	dd_Smed_v4_552_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30021597	SMESG000041391.1	dd_Smed_v4_552_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP2 (cyclin dependent kinase 2 associated protein 2 [Source:HGNC Symbol;Acc:HGNC:30833])

HSP 1 Score: 67.0106 bits (162), Expect = 1.491e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   63 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 122

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14002])

HSP 1 Score: 64.3142 bits (155), Expect = 5.638e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87

[Close]

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87

[Close]

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87

[Close]

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Match: Y43F4B.10 (pep chromosome:WBcel235:III:13314011:13314721:1 gene:WBGene00012807.1 transcript:Y43F4B.10.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y43F4B.10)

HSP 1 Score: 65.0846 bits (157), Expect = 1.981e-15
Identity = 28/67 (41.79%), Postives = 43/67 (64.18%), Query Frame = 1

Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELE 201
            +   I ++P   + E T  Y  LL++I+EIG+D++P Y  NK+  ERLK+NI  A++L+R C  E E
Sbjct:    7 LQTLISIVPNLQMQEGTPYYEVLLKLIEEIGKDVRPTYTFNKLTCERLKRNIQAAKVLIRACQQEAE 73

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Match: Y43F4B.10 (pep chromosome:WBcel235:III:13314068:13314721:1 gene:WBGene00012807.1 transcript:Y43F4B.10.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y43F4B.10)

HSP 1 Score: 65.0846 bits (157), Expect = 1.981e-15
Identity = 28/67 (41.79%), Postives = 43/67 (64.18%), Query Frame = 1

Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELE 201
            +   I ++P   + E T  Y  LL++I+EIG+D++P Y  NK+  ERLK+NI  A++L+R C  E E
Sbjct:    7 LQTLISIVPNLQMQEGTPYYEVLLKLIEEIGKDVRPTYTFNKLTCERLKRNIQAAKVLIRACQQEAE 73

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Match: CDK2AP1 (gene:FBgn0030269 transcript:FBtr0073437)

HSP 1 Score: 70.0922 bits (170), Expect = 4.544e-16
Identity = 34/68 (50.00%), Postives = 44/68 (64.71%), Query Frame = 1

Query:   10 SIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
            S   LP    G   +KY  LL VI+E+GRDI+P Y G++ ++ERLK+ I  ARILVREC  E ER  +
Sbjct:  213 STASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAAR 280

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Match: CDK2AP1 (gene:FBgn0030269 transcript:FBtr0330387)

HSP 1 Score: 70.0922 bits (170), Expect = 6.151e-16
Identity = 34/69 (49.28%), Postives = 44/69 (63.77%), Query Frame = 1

Query:    7 NSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
             S   LP    G   +KY  LL VI+E+GRDI+P Y G++ ++ERLK+ I  ARILVREC  E ER  +
Sbjct:  212 TSTASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAAR 280

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.6254 bits (161), Expect = 7.352e-16
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1

Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   42 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 108

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.6254 bits (161), Expect = 9.214e-16
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1

Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   50 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 116

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.2402 bits (160), Expect = 1.302e-15
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1

Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   49 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 115

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: cdk2ap2 (cyclin-dependent kinase 2 associated protein 2 [Source:ZFIN;Acc:ZDB-GENE-040718-35])

HSP 1 Score: 64.3142 bits (155), Expect = 6.741e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Match: cldn15.1 (claudin 15, gene 1 [Source:Xenbase;Acc:XB-GENE-994817])

HSP 1 Score: 65.4698 bits (158), Expect = 4.773e-15
Identity = 32/61 (52.46%), Postives = 44/61 (72.13%), Query Frame = 1

Query:   28 QPPVGENTSK--YNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +P V +  S+  Y++LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   57 KPAVSQAVSQGTYSDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 117

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Match: sult4a1 (sulfotransferase family 4A member 1 [Source:Xenbase;Acc:XB-GENE-979812])

HSP 1 Score: 64.6994 bits (156), Expect = 9.755e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   66 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 120

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap2 (CDK2-associated protein 2 [Source:MGI Symbol;Acc:MGI:1098779])

HSP 1 Score: 67.0106 bits (162), Expect = 1.094e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123

[Close]

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap1 (CDK2 (cyclin-dependent kinase 2)-associated protein 1 [Source:MGI Symbol;Acc:MGI:1202069])

HSP 1 Score: 65.0846 bits (157), Expect = 2.291e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87

[Close]

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87

[Close]

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|O75956|CDKA2_HUMAN (Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.158e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   63 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 122

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|Q58CN7|CDKA2_BOVIN (Cyclin-dependent kinase 2-associated protein 2 OS=Bos taurus OX=9913 GN=CDK2AP2 PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.168e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|Q9CPY4|CDKA2_MOUSE (Cyclin-dependent kinase 2-associated protein 2 OS=Mus musculus OX=10090 GN=Cdk2ap2 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.650e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1

Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|O35207|CDKA1_MOUSE (Cyclin-dependent kinase 2-associated protein 1 OS=Mus musculus OX=10090 GN=Cdk2ap1 PE=1 SV=2)

HSP 1 Score: 65.4698 bits (158), Expect = 2.340e-14
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   60 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 114

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|P49119|CDKA1_MESAU (Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus OX=10036 GN=CDK2AP1 PE=2 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 2.340e-14
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1

Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   60 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 114

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: Q5BSD1 (Cyclin-dependent kinase 2-associated protein OS=Schistosoma japonicum OX=6182 GN=EWB00_011294 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 6.492e-26
Identity = 50/72 (69.44%), Postives = 59/72 (81.94%), Query Frame = 1

Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY++LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVNYPMMPPMDDLNKYSHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: C1L483 (Cyclin-dependent kinase 2-associated protein 2 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 6.528e-26
Identity = 50/72 (69.44%), Postives = 59/72 (81.94%), Query Frame = 1

Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY++LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    5 NTSIPVNYPMMPPMDDLNKYSHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 76

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A183JIP0 (Uncharacterized protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS2565 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.430e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1

Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVSYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A183M052 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS9427 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.430e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1

Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVSYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A5K4FCR2 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 1.579e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1

Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVNYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: CDK2AP1 (cyclin-dependent kinase 2-associated protein 1-like [Source:NCBI gene;Acc:103046776])

HSP 1 Score: 65.4698 bits (158), Expect = 2.229e-15
Identity = 34/63 (53.97%), Postives = 43/63 (68.25%), Query Frame = 1

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QPP     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   61 QPP----QSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 119

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: ENSAMXT00000039422.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000873.1:121163:125488:1 gene:ENSAMXG00000035299.1 transcript:ENSAMXT00000039422.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 2.750e-15
Identity = 30/54 (55.56%), Postives = 41/54 (75.93%), Query Frame = 1

Query:   55 KYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            KY+ LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER ++S
Sbjct:   16 KYSELLGIIEELGKEIRPTYAGSKTAMERLKRGIIHARGLVRECLAETERNVRS 69

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: cdk2ap2 (cyclin-dependent kinase 2-associated protein 2-like [Source:NCBI gene;Acc:103032531])

HSP 1 Score: 64.3142 bits (155), Expect = 6.165e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: CDK2AP1 (cyclin-dependent kinase 2-associated protein 1-like [Source:NCBI gene;Acc:103046776])

HSP 1 Score: 46.9802 bits (110), Expect = 3.220e-8
Identity = 22/42 (52.38%), Postives = 30/42 (71.43%), Query Frame = 1

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKN 153
            QPP     SKY  LL +I+E+G++I+P YAG+K A ERLK+ 
Sbjct:   61 QPP----QSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRG 98

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Nematostella
Match: EDO47489 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLV5])

HSP 1 Score: 69.3218 bits (168), Expect = 6.903e-18
Identity = 34/56 (60.71%), Postives = 41/56 (73.21%), Query Frame = 1

Query:   46 NTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
            + SKY  LL VI+E+G+DI+P YAG+K ASERLKK I  AR LVREC  E ER  +
Sbjct:    7 SQSKYGELLAVIEELGKDIRPTYAGSKNASERLKKGIMHARALVRECLIETERCAR 62

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Match: cdk2ap2 (cyclin dependent kinase 2 associated protein 2 [Source:NCBI gene;Acc:101168841])

HSP 1 Score: 64.6994 bits (156), Expect = 4.097e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111

[Close]

Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:101170282])

HSP 1 Score: 63.1586 bits (152), Expect = 2.189e-14
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1

Query:   55 KYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            KY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   67 KYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 120

[Close]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Planmine SMEST
Match: SMESG000041391.1 (SMESG000041391.1)

HSP 1 Score: 148.673 bits (374), Expect = 6.711e-49
Identity = 72/72 (100.00%), Postives = 72/72 (100.00%), Query Frame = 1

Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS
Sbjct:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 72

The following BLAST results are available for this feature:

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Sea Lamprey
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Yeast
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Nematostella
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Planmine SMEST

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CDK2AP2	1.491e-15	53.33	cyclin dependent kinase 2 associated protein 2 [So...	[more]
CDK2AP1	5.638e-15	56.36	cyclin dependent kinase 2 associated protein 1 [So...	[more]
CDK2AP1	5.638e-15	56.36	cyclin dependent kinase 2 associated protein 1 [So...	[more]
CDK2AP1	5.638e-15	56.36	cyclin dependent kinase 2 associated protein 1 [So...	[more]
CDK2AP1	5.638e-15	56.36	cyclin dependent kinase 2 associated protein 1 [So...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Y43F4B.10	1.981e-15	41.79	pep chromosome:WBcel235:III:13314011:13314721:1 ge...	[more]
Y43F4B.10	1.981e-15	41.79	pep chromosome:WBcel235:III:13314068:13314721:1 ge...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CDK2AP1	4.544e-16	50.00	gene:FBgn0030269 transcript:FBtr0073437	[more]
CDK2AP1	6.151e-16	49.28	gene:FBgn0030269 transcript:FBtr0330387	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CDK2AP1	7.352e-16	52.24	cyclin dependent kinase 2 associated protein 1 [So...	[more]
CDK2AP1	9.214e-16	52.24	cyclin dependent kinase 2 associated protein 1 [So...	[more]
CDK2AP1	1.302e-15	52.24	cyclin dependent kinase 2 associated protein 1 [So...	[more]
cdk2ap2	6.741e-15	50.79	cyclin-dependent kinase 2 associated protein 2 [So...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cldn15.1	4.773e-15	52.46	claudin 15, gene 1 [Source:Xenbase;Acc:XB-GENE-994...	[more]
sult4a1	9.755e-15	56.36	sulfotransferase family 4A member 1 [Source:Xenbas...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cdk2ap2	1.094e-15	53.33	CDK2-associated protein 2 [Source:MGI Symbol;Acc:M...	[more]
Cdk2ap2	1.094e-15	53.33	CDK2-associated protein 2 [Source:MGI Symbol;Acc:M...	[more]
Cdk2ap1	2.291e-15	56.36	CDK2 (cyclin-dependent kinase 2)-associated protei...	[more]
Cdk2ap1	2.291e-15	56.36	CDK2 (cyclin-dependent kinase 2)-associated protei...	[more]
Cdk2ap1	2.291e-15	56.36	CDK2 (cyclin-dependent kinase 2)-associated protei...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O75956\|CDKA2_HUMAN	7.158e-15	53.33	Cyclin-dependent kinase 2-associated protein 2 OS=...	[more]
sp\|Q58CN7\|CDKA2_BOVIN	7.168e-15	53.33	Cyclin-dependent kinase 2-associated protein 2 OS=...	[more]
sp\|Q9CPY4\|CDKA2_MOUSE	7.650e-15	53.33	Cyclin-dependent kinase 2-associated protein 2 OS=...	[more]
sp\|O35207\|CDKA1_MOUSE	2.340e-14	56.36	Cyclin-dependent kinase 2-associated protein 1 OS=...	[more]
sp\|P49119\|CDKA1_MESAU	2.340e-14	56.36	Cyclin-dependent kinase 2-associated protein 1 OS=...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
Q5BSD1	6.492e-26	69.44	Cyclin-dependent kinase 2-associated protein OS=Sc...	[more]
C1L483	6.528e-26	69.44	Cyclin-dependent kinase 2-associated protein 2 OS=...	[more]
A0A183JIP0	1.430e-25	69.44	Uncharacterized protein OS=Schistosoma curassoni O...	[more]
A0A183M052	1.430e-25	69.44	Uncharacterized protein OS=Schistosoma margrebowie...	[more]
A0A5K4FCR2	1.579e-25	69.44	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
CDK2AP1	2.229e-15	53.97	cyclin-dependent kinase 2-associated protein 1-lik...	[more]
ENSAMXT00000039422.1	2.750e-15	55.56	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
cdk2ap2	6.165e-15	50.79	cyclin-dependent kinase 2-associated protein 2-lik...	[more]
CDK2AP1	3.220e-8	52.38	cyclin-dependent kinase 2-associated protein 1-lik...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO47489	6.903e-18	60.71	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
cdk2ap2	4.097e-15	50.79	cyclin dependent kinase 2 associated protein 2 [So...	[more]
cdk2ap2	4.097e-15	50.79	cyclin dependent kinase 2 associated protein 2 [So...	[more]
CDK2AP1	2.189e-14	55.56	cyclin dependent kinase 2 associated protein 1 [So...	[more]

BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000041391.1	6.711e-49	100.00	SMESG000041391.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30021597 ID=SMED30021597|Name=Cyclin-dependent kinase 2-associated protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=219bp
ATGAATAATTCTATCCCAGTTTTGCCTCAACCGCCAGTAGGGGAGAATAC
TAGCAAATATAATAATCTTCTTCAAGTAATTGATGAAATAGGAAGAGATA
TAAAACCGGCTTATGCTGGCAATAAAATGGCGAGTGAACGGTTAAAGAAA
AATATTCATACTGCTAGAATTCTTGTTCGGGAATGTGCAGGCGAGTTAGA
GAGAGTTATGAAAAGTTAA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0003001	lateral region of the whole animal

Vocabulary: **INTERPRO**
Term	Definition
IPR017266	DOC_1/2
IPR019187	Cyclin-dep_kinase2-assoc_pr

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR017266	Cyclin-dependent kinase 2-associated protein 1/2	PFAM	PF09806	CDK2AP	coord: 17..68 e-value: 1.7E-16 score: 61.0
IPR017266	Cyclin-dependent kinase 2-associated protein 1/2	PANTHER	PTHR22607	DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1	coord: 3..69
None	No IPR available	PANTHER	PTHR22607:SF3	CDK2-ASSOCIATED PROTEIN 1, ISOFORM B	coord: 3..69

Main menu

Cyclin-dependent kinase 2-associated protein 2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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