Cyclin-dependent kinase 2-associated protein 2

Overview
NameCyclin-dependent kinase 2-associated protein 2
Smed IDSMED30021597
Length (bp)219
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) t-SNE clustered cells

Violin plots show distribution of expression levels for Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cyclin-dependent kinase 2-associated protein 2 (SMED30021597) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30021597

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30021597 SmedASXL_053139SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30021597 dd_Smed_v4_552_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30021597 dd_Smed_v4_552_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30021597 dd_Smed_v4_552_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30021597 dd_Smed_v4_552_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30021597 dd_Smed_v4_552_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP2 (cyclin dependent kinase 2 associated protein 2 [Source:HGNC Symbol;Acc:HGNC:30833])

HSP 1 Score: 67.0106 bits (162), Expect = 1.491e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   63 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 122          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14002])

HSP 1 Score: 64.3142 bits (155), Expect = 5.638e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14002])

HSP 1 Score: 64.3142 bits (155), Expect = 5.638e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14002])

HSP 1 Score: 64.3142 bits (155), Expect = 5.638e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14002])

HSP 1 Score: 64.3142 bits (155), Expect = 5.638e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Match: Y43F4B.10 (pep chromosome:WBcel235:III:13314011:13314721:1 gene:WBGene00012807.1 transcript:Y43F4B.10.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y43F4B.10)

HSP 1 Score: 65.0846 bits (157), Expect = 1.981e-15
Identity = 28/67 (41.79%), Postives = 43/67 (64.18%), Query Frame = 1
Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELE 201
            +   I ++P   + E T  Y  LL++I+EIG+D++P Y  NK+  ERLK+NI  A++L+R C  E E
Sbjct:    7 LQTLISIVPNLQMQEGTPYYEVLLKLIEEIGKDVRPTYTFNKLTCERLKRNIQAAKVLIRACQQEAE 73          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Match: Y43F4B.10 (pep chromosome:WBcel235:III:13314068:13314721:1 gene:WBGene00012807.1 transcript:Y43F4B.10.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y43F4B.10)

HSP 1 Score: 65.0846 bits (157), Expect = 1.981e-15
Identity = 28/67 (41.79%), Postives = 43/67 (64.18%), Query Frame = 1
Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELE 201
            +   I ++P   + E T  Y  LL++I+EIG+D++P Y  NK+  ERLK+NI  A++L+R C  E E
Sbjct:    7 LQTLISIVPNLQMQEGTPYYEVLLKLIEEIGKDVRPTYTFNKLTCERLKRNIQAAKVLIRACQQEAE 73          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Match: CDK2AP1 (gene:FBgn0030269 transcript:FBtr0073437)

HSP 1 Score: 70.0922 bits (170), Expect = 4.544e-16
Identity = 34/68 (50.00%), Postives = 44/68 (64.71%), Query Frame = 1
Query:   10 SIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
            S   LP    G   +KY  LL VI+E+GRDI+P Y G++ ++ERLK+ I  ARILVREC  E ER  +
Sbjct:  213 STASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAAR 280          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Match: CDK2AP1 (gene:FBgn0030269 transcript:FBtr0330387)

HSP 1 Score: 70.0922 bits (170), Expect = 6.151e-16
Identity = 34/69 (49.28%), Postives = 44/69 (63.77%), Query Frame = 1
Query:    7 NSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
             S   LP    G   +KY  LL VI+E+GRDI+P Y G++ ++ERLK+ I  ARILVREC  E ER  +
Sbjct:  212 TSTASLPSVGPGNGLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHARILVRECLMETERAAR 280          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.6254 bits (161), Expect = 7.352e-16
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1
Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   42 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 108          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.6254 bits (161), Expect = 9.214e-16
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1
Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   50 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 116          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:108191561])

HSP 1 Score: 66.2402 bits (160), Expect = 1.302e-15
Identity = 35/67 (52.24%), Postives = 44/67 (65.67%), Query Frame = 1
Query:   22 LPQPPVGENT--SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
             PQ P G     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   49 FPQGPNGGQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 115          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Match: cdk2ap2 (cyclin-dependent kinase 2 associated protein 2 [Source:ZFIN;Acc:ZDB-GENE-040718-35])

HSP 1 Score: 64.3142 bits (155), Expect = 6.741e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Match: cldn15.1 (claudin 15, gene 1 [Source:Xenbase;Acc:XB-GENE-994817])

HSP 1 Score: 65.4698 bits (158), Expect = 4.773e-15
Identity = 32/61 (52.46%), Postives = 44/61 (72.13%), Query Frame = 1
Query:   28 QPPVGENTSK--YNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +P V +  S+  Y++LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   57 KPAVSQAVSQGTYSDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 117          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Match: sult4a1 (sulfotransferase family 4A member 1 [Source:Xenbase;Acc:XB-GENE-979812])

HSP 1 Score: 64.6994 bits (156), Expect = 9.755e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   66 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 120          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap2 (CDK2-associated protein 2 [Source:MGI Symbol;Acc:MGI:1098779])

HSP 1 Score: 67.0106 bits (162), Expect = 1.094e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap2 (CDK2-associated protein 2 [Source:MGI Symbol;Acc:MGI:1098779])

HSP 1 Score: 67.0106 bits (162), Expect = 1.094e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap1 (CDK2 (cyclin-dependent kinase 2)-associated protein 1 [Source:MGI Symbol;Acc:MGI:1202069])

HSP 1 Score: 65.0846 bits (157), Expect = 2.291e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap1 (CDK2 (cyclin-dependent kinase 2)-associated protein 1 [Source:MGI Symbol;Acc:MGI:1202069])

HSP 1 Score: 65.0846 bits (157), Expect = 2.291e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Match: Cdk2ap1 (CDK2 (cyclin-dependent kinase 2)-associated protein 1 [Source:MGI Symbol;Acc:MGI:1202069])

HSP 1 Score: 65.0846 bits (157), Expect = 2.291e-15
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   33 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 87          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|O75956|CDKA2_HUMAN (Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.158e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   63 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 122          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|Q58CN7|CDKA2_BOVIN (Cyclin-dependent kinase 2-associated protein 2 OS=Bos taurus OX=9913 GN=CDK2AP2 PE=2 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.168e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|Q9CPY4|CDKA2_MOUSE (Cyclin-dependent kinase 2-associated protein 2 OS=Mus musculus OX=10090 GN=Cdk2ap2 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.650e-15
Identity = 32/60 (53.33%), Postives = 43/60 (71.67%), Query Frame = 1
Query:   28 QPPVGENT-SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELER 204
            +PP  + + S Y +LL VI+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER
Sbjct:   64 KPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETER 123          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|O35207|CDKA1_MOUSE (Cyclin-dependent kinase 2-associated protein 1 OS=Mus musculus OX=10090 GN=Cdk2ap1 PE=1 SV=2)

HSP 1 Score: 65.4698 bits (158), Expect = 2.340e-14
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   60 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 114          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Match: sp|P49119|CDKA1_MESAU (Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus OX=10036 GN=CDK2AP1 PE=2 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 2.340e-14
Identity = 31/55 (56.36%), Postives = 40/55 (72.73%), Query Frame = 1
Query:   52 SKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   60 SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVRECLAETERNARS 114          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: Q5BSD1 (Cyclin-dependent kinase 2-associated protein OS=Schistosoma japonicum OX=6182 GN=EWB00_011294 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 6.492e-26
Identity = 50/72 (69.44%), Postives = 59/72 (81.94%), Query Frame = 1
Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY++LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVNYPMMPPMDDLNKYSHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: C1L483 (Cyclin-dependent kinase 2-associated protein 2 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 6.528e-26
Identity = 50/72 (69.44%), Postives = 59/72 (81.94%), Query Frame = 1
Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY++LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    5 NTSIPVNYPMMPPMDDLNKYSHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 76          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A183JIP0 (Uncharacterized protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS2565 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.430e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1
Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVSYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A183M052 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS9427 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.430e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1
Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVSYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Match: A0A5K4FCR2 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 1.579e-25
Identity = 50/72 (69.44%), Postives = 58/72 (80.56%), Query Frame = 1
Query:    4 NNSIPV-LPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            N SIPV  P  P  ++ +KY +LLQVI+E+GRDIKP YA NK A+ERLKKNIHTARILVREC  ELERVMK+
Sbjct:    4 NTSIPVNYPMMPPMDDLNKYAHLLQVIEEMGRDIKPTYANNKNAAERLKKNIHTARILVRECVSELERVMKA 75          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: CDK2AP1 (cyclin-dependent kinase 2-associated protein 1-like [Source:NCBI gene;Acc:103046776])

HSP 1 Score: 65.4698 bits (158), Expect = 2.229e-15
Identity = 34/63 (53.97%), Postives = 43/63 (68.25%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QPP     SKY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   61 QPP----QSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 119          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: ENSAMXT00000039422.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000873.1:121163:125488:1 gene:ENSAMXG00000035299.1 transcript:ENSAMXT00000039422.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.929 bits (154), Expect = 2.750e-15
Identity = 30/54 (55.56%), Postives = 41/54 (75.93%), Query Frame = 1
Query:   55 KYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            KY+ LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER ++S
Sbjct:   16 KYSELLGIIEELGKEIRPTYAGSKTAMERLKRGIIHARGLVRECLAETERNVRS 69          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: cdk2ap2 (cyclin-dependent kinase 2-associated protein 2-like [Source:NCBI gene;Acc:103032531])

HSP 1 Score: 64.3142 bits (155), Expect = 6.165e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Match: CDK2AP1 (cyclin-dependent kinase 2-associated protein 1-like [Source:NCBI gene;Acc:103046776])

HSP 1 Score: 46.9802 bits (110), Expect = 3.220e-8
Identity = 22/42 (52.38%), Postives = 30/42 (71.43%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKN 153
            QPP     SKY  LL +I+E+G++I+P YAG+K A ERLK+ 
Sbjct:   61 QPP----QSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRG 98          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Nematostella
Match: EDO47489 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RLV5])

HSP 1 Score: 69.3218 bits (168), Expect = 6.903e-18
Identity = 34/56 (60.71%), Postives = 41/56 (73.21%), Query Frame = 1
Query:   46 NTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMK 213
            + SKY  LL VI+E+G+DI+P YAG+K ASERLKK I  AR LVREC  E ER  +
Sbjct:    7 SQSKYGELLAVIEELGKDIRPTYAGSKNASERLKKGIMHARALVRECLIETERCAR 62          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Match: cdk2ap2 (cyclin dependent kinase 2 associated protein 2 [Source:NCBI gene;Acc:101168841])

HSP 1 Score: 64.6994 bits (156), Expect = 4.097e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Match: cdk2ap2 (cyclin dependent kinase 2 associated protein 2 [Source:NCBI gene;Acc:101168841])

HSP 1 Score: 64.6994 bits (156), Expect = 4.097e-15
Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query:   28 QPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            QP      S Y+ LL VI+E+ R+I+P YAG+K A ERLK+ I  AR LVREC  E ER  ++
Sbjct:   49 QPVKVSQGSTYSELLSVIEEMSREIRPTYAGSKSAMERLKRGIIHARALVRECLAETERSART 111          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Match: CDK2AP1 (cyclin dependent kinase 2 associated protein 1 [Source:NCBI gene;Acc:101170282])

HSP 1 Score: 63.1586 bits (152), Expect = 2.189e-14
Identity = 30/54 (55.56%), Postives = 39/54 (72.22%), Query Frame = 1
Query:   55 KYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            KY  LL +I+E+G++I+P YAG+K A ERLK+ I  AR LVREC  E ER  +S
Sbjct:   67 KYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS 120          
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Planmine SMEST
Match: SMESG000041391.1 (SMESG000041391.1)

HSP 1 Score: 148.673 bits (374), Expect = 6.711e-49
Identity = 72/72 (100.00%), Postives = 72/72 (100.00%), Query Frame = 1
Query:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 216
            MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS
Sbjct:    1 MNNSIPVLPQPPVGENTSKYNNLLQVIDEIGRDIKPAYAGNKMASERLKKNIHTARILVRECAGELERVMKS 72          
The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CDK2AP21.491e-1553.33cyclin dependent kinase 2 associated protein 2 [So... [more]
CDK2AP15.638e-1556.36cyclin dependent kinase 2 associated protein 1 [So... [more]
CDK2AP15.638e-1556.36cyclin dependent kinase 2 associated protein 1 [So... [more]
CDK2AP15.638e-1556.36cyclin dependent kinase 2 associated protein 1 [So... [more]
CDK2AP15.638e-1556.36cyclin dependent kinase 2 associated protein 1 [So... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Y43F4B.101.981e-1541.79pep chromosome:WBcel235:III:13314011:13314721:1 ge... [more]
Y43F4B.101.981e-1541.79pep chromosome:WBcel235:III:13314068:13314721:1 ge... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CDK2AP14.544e-1650.00gene:FBgn0030269 transcript:FBtr0073437[more]
CDK2AP16.151e-1649.28gene:FBgn0030269 transcript:FBtr0330387[more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
CDK2AP17.352e-1652.24cyclin dependent kinase 2 associated protein 1 [So... [more]
CDK2AP19.214e-1652.24cyclin dependent kinase 2 associated protein 1 [So... [more]
CDK2AP11.302e-1552.24cyclin dependent kinase 2 associated protein 1 [So... [more]
cdk2ap26.741e-1550.79cyclin-dependent kinase 2 associated protein 2 [So... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
cldn15.14.773e-1552.46claudin 15, gene 1 [Source:Xenbase;Acc:XB-GENE-994... [more]
sult4a19.755e-1556.36sulfotransferase family 4A member 1 [Source:Xenbas... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cdk2ap21.094e-1553.33CDK2-associated protein 2 [Source:MGI Symbol;Acc:M... [more]
Cdk2ap21.094e-1553.33CDK2-associated protein 2 [Source:MGI Symbol;Acc:M... [more]
Cdk2ap12.291e-1556.36CDK2 (cyclin-dependent kinase 2)-associated protei... [more]
Cdk2ap12.291e-1556.36CDK2 (cyclin-dependent kinase 2)-associated protei... [more]
Cdk2ap12.291e-1556.36CDK2 (cyclin-dependent kinase 2)-associated protei... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O75956|CDKA2_HUMAN7.158e-1553.33Cyclin-dependent kinase 2-associated protein 2 OS=... [more]
sp|Q58CN7|CDKA2_BOVIN7.168e-1553.33Cyclin-dependent kinase 2-associated protein 2 OS=... [more]
sp|Q9CPY4|CDKA2_MOUSE7.650e-1553.33Cyclin-dependent kinase 2-associated protein 2 OS=... [more]
sp|O35207|CDKA1_MOUSE2.340e-1456.36Cyclin-dependent kinase 2-associated protein 1 OS=... [more]
sp|P49119|CDKA1_MESAU2.340e-1456.36Cyclin-dependent kinase 2-associated protein 1 OS=... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q5BSD16.492e-2669.44Cyclin-dependent kinase 2-associated protein OS=Sc... [more]
C1L4836.528e-2669.44Cyclin-dependent kinase 2-associated protein 2 OS=... [more]
A0A183JIP01.430e-2569.44Uncharacterized protein OS=Schistosoma curassoni O... [more]
A0A183M0521.430e-2569.44Uncharacterized protein OS=Schistosoma margrebowie... [more]
A0A5K4FCR21.579e-2569.44Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
CDK2AP12.229e-1553.97cyclin-dependent kinase 2-associated protein 1-lik... [more]
ENSAMXT00000039422.12.750e-1555.56pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
cdk2ap26.165e-1550.79cyclin-dependent kinase 2-associated protein 2-lik... [more]
CDK2AP13.220e-852.38cyclin-dependent kinase 2-associated protein 1-lik... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO474896.903e-1860.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
cdk2ap24.097e-1550.79cyclin dependent kinase 2 associated protein 2 [So... [more]
cdk2ap24.097e-1550.79cyclin dependent kinase 2 associated protein 2 [So... [more]
CDK2AP12.189e-1455.56cyclin dependent kinase 2 associated protein 1 [So... [more]
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BLAST of Cyclin-dependent kinase 2-associated protein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000041391.16.711e-49100.00SMESG000041391.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021597 ID=SMED30021597|Name=Cyclin-dependent kinase 2-associated protein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=219bp
ATGAATAATTCTATCCCAGTTTTGCCTCAACCGCCAGTAGGGGAGAATAC
TAGCAAATATAATAATCTTCTTCAAGTAATTGATGAAATAGGAAGAGATA
TAAAACCGGCTTATGCTGGCAATAAAATGGCGAGTGAACGGTTAAAGAAA
AATATTCATACTGCTAGAATTCTTGTTCGGGAATGTGCAGGCGAGTTAGA
GAGAGTTATGAAAAGTTAA
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0003001lateral region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR017266DOC_1/2
IPR019187Cyclin-dep_kinase2-assoc_pr
Vocabulary: molecular function
TermDefinition
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR017266Cyclin-dependent kinase 2-associated protein 1/2PFAMPF09806CDK2APcoord: 17..68
e-value: 1.7E-16
score: 61.0
IPR017266Cyclin-dependent kinase 2-associated protein 1/2PANTHERPTHR22607DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1coord: 3..69
NoneNo IPR availablePANTHERPTHR22607:SF3CDK2-ASSOCIATED PROTEIN 1, ISOFORM Bcoord: 3..69