5-hydroxytryptamine receptor 2C
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021550 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 18
Homology
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Match: HTR1A (5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286]) HSP 1 Score: 150.984 bits (380), Expect = 3.488e-39 Identity = 124/456 (27.19%), Postives = 208/456 (45.61%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTK--SRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S D+ H + I ST F +PL +M+V Y + + + + + + T+ + P Q K +S+N + S + +GV+ K G+ +R+ D + + + + + + S + + PT RKN N+ AKR + A+ +K V+ LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSDP-DACTISKDHG--YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPK-----KSVNGESGSRN-----WRLGVESK----------------AGGAL-------------CANGAVRQGDDGAALEVIEVHR----VGNSKEHLPLPSEAGPTPCAPASFERKNERNA---------EAKRKM-ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Match: DRD3 (dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024]) HSP 1 Score: 145.976 bits (367), Expect = 1.729e-37 Identity = 120/452 (26.55%), Postives = 197/452 (43.58%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN--NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS---LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP-LTQIKITDDSQSIN-ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L ++GN LVC++V E+ LQ N+ +VSLA++DLL A LVMP + V NF+ R C + +LDV + +I++LC+IS+DRY + P+ Y + +SS + L I+ W++ F ++CPL G N P +SN F+I S+V++F LP + ++ Y ++ +++Q + R N RP Q ++ D + + S D + G + + G K K ++ S +PK +L ++K S+ + S K+ P Q R R KKA Q++ I+ G F++C+LPFF+ ++L+ C C ++ L S T W+GY S LNP++Y FN FR F +++ C
Sbjct: 41 LAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF---------GFNTTGDPTVCSISNPD-----------------FVIYSSVVSFYLPFGVTVLVYA-RIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQE-----------------RGGELKREEKTRNSL-----------SPTIAPKLSLEVRKLSN------GRLSTSLKLGPL--------------------QPRGVPLRE-------KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCH-VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Match: DRD3 (dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024]) HSP 1 Score: 145.976 bits (367), Expect = 1.729e-37 Identity = 120/452 (26.55%), Postives = 197/452 (43.58%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN--NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS---LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP-LTQIKITDDSQSIN-ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L ++GN LVC++V E+ LQ N+ +VSLA++DLL A LVMP + V NF+ R C + +LDV + +I++LC+IS+DRY + P+ Y + +SS + L I+ W++ F ++CPL G N P +SN F+I S+V++F LP + ++ Y ++ +++Q + R N RP Q ++ D + + S D + G + + G K K ++ S +PK +L ++K S+ + S K+ P Q R R KKA Q++ I+ G F++C+LPFF+ ++L+ C C ++ L S T W+GY S LNP++Y FN FR F +++ C
Sbjct: 41 LAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF---------GFNTTGDPTVCSISNPD-----------------FVIYSSVVSFYLPFGVTVLVYA-RIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQE-----------------RGGELKREEKTRNSL-----------SPTIAPKLSLEVRKLSN------GRLSTSLKLGPL--------------------QPRGVPLRE-------KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCH-VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Match: DRD3 (dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024]) HSP 1 Score: 145.976 bits (367), Expect = 1.729e-37 Identity = 120/452 (26.55%), Postives = 197/452 (43.58%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN--NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS---LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP-LTQIKITDDSQSIN-ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L ++GN LVC++V E+ LQ N+ +VSLA++DLL A LVMP + V NF+ R C + +LDV + +I++LC+IS+DRY + P+ Y + +SS + L I+ W++ F ++CPL G N P +SN F+I S+V++F LP + ++ Y ++ +++Q + R N RP Q ++ D + + S D + G + + G K K ++ S +PK +L ++K S+ + S K+ P Q R R KKA Q++ I+ G F++C+LPFF+ ++L+ C C ++ L S T W+GY S LNP++Y FN FR F +++ C
Sbjct: 41 LAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF---------GFNTTGDPTVCSISNPD-----------------FVIYSSVVSFYLPFGVTVLVYA-RIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQE-----------------RGGELKREEKTRNSL-----------SPTIAPKLSLEVRKLSN------GRLSTSLKLGPL--------------------QPRGVPLRE-------KKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCH-VSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Match: DRD2 (dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023]) HSP 1 Score: 137.887 bits (346), Expect = 1.928e-34 Identity = 130/477 (27.25%), Postives = 220/477 (46.12%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTI--WGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSF---KISHKNEFTIHLNVPTTDMRRS-YDFSPKQNLAIKKQSSLIDKSFQSFNNS--FKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN-------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
DR + + L+ L + +GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ R C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + ISI W++ F I+CPL +F L NN + NE C N F++ S++++F +P + ++ YI ++ ++R+ R+ + +SS R + + + T+ D + ++ + + PV R E + + T+ R+ Y P + Q +L D S +++ P + G+ K ++ F I + +L M+ KKA Q+L I+ G+F++C+LPFF+ ++L+ C C + L S W+GY S +NPI+Y FN FR F +++ C
Sbjct: 30 DRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS---RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISIVWVLSFTISCPL-LFGL-------NNAD--------QNE-----------CIIANPAFVVYSSIVSFYVPFIVTLLVYI-KIYIVLRRR---RKRVNTKRSSRAFRAHLRAPLKGNC------THPEDMKLCTVIMKSNGSF-------------PVNRRRVVQEAARRAQELEMEMLSSTSPPERTRYSPIPPSH----HQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPK-IAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 445
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 142.895 bits (359), Expect = 9.463e-36 Identity = 135/501 (26.95%), Postives = 225/501 (44.91%), Query Frame = 3
Query: 246 LGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY--ILTVWS----IIRQT----------NQARQNLYPNKSSTKSRP--LTQIKITDDSQSIN------ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHL--NVPTTDMRRSYDFSPKQNLAIKKQSSLID-----KSFQSFNNSFKMSP--TRYGNQLSIR---KNLSNSFRIHKQSRNSAKRTLAAMNS-----GKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTE----WIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYK 1613
L L+++ L TI+GN LV +SV + KR++ N L SLA +DLL L+VMP+S +++ N+ + + R +C W + DV + +I++LC ISLDRYF + +PLKY TR R ++ W I F + P ++ + NN N + + +K +V + I S + +F LPL +M+ Y I V S ++RQ+ + +Q N T S P T++++ + +N E N +N + S D C DSP S + ++ L N P +++ +N ++ SL D + N ++P ++ Q + R NL H Q K + +KA++ +GI+ F++C++PFF++YL++ F I P+ T W+GYS S+LNPI+Y ++N FR F L+ C +
Sbjct: 104 LFLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRW-PLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIP-SWNLFIDNNNN-------------TGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNHNCGRVNYSVRPVEYANRVENSLKPSHERFDSTDC---------EDSPPNGDSLEAGTTCNISMSLVTNSPPNGLQKE-----AKNSMERECHSLADIVNSADTPVRKNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGSKEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVF-ISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQ 574
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 142.51 bits (358), Expect = 1.087e-35 Identity = 135/501 (26.95%), Postives = 225/501 (44.91%), Query Frame = 3
Query: 246 LGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY--ILTVWS----IIRQT----------NQARQNLYPNKSSTKSRP--LTQIKITDDSQSIN------ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHL--NVPTTDMRRSYDFSPKQNLAIKKQSSLID-----KSFQSFNNSFKMSP--TRYGNQLSIR---KNLSNSFRIHKQSRNSAKRTLAAMNS-----GKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTE----WIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYK 1613
L L+++ L TI+GN LV +SV + KR++ N L SLA +DLL L+VMP+S +++ N+ + + R +C W + DV + +I++LC ISLDRYF + +PLKY TR R ++ W I F + P ++ + NN N + + +K +V + I S + +F LPL +M+ Y I V S ++RQ+ + +Q N T S P T++++ + +N E N +N + S D C DSP S + ++ L N P +++ +N ++ SL D + N ++P ++ Q + R NL H Q K + +KA++ +GI+ F++C++PFF++YL++ F I P+ T W+GYS S+LNPI+Y ++N FR F L+ C +
Sbjct: 76 LFLVMLILLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRW-PLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWVIP-SWNLFIDNNNN-------------TGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNHNCGRVNYSVRPVEYANRVENSLKPSHERFDSTDC---------EDSPPNGDSLEAGTTCNISMSLVTNSPPNGLQKE-----AKNSMERECHSLADIVNSADTPVRKNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGSKEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVF-ISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQ 546
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Match: tyra-3 (TYRAmine receptor [Source:UniProtKB/TrEMBL;Acc:Q2L6V9]) HSP 1 Score: 140.969 bits (354), Expect = 1.167e-35 Identity = 132/495 (26.67%), Postives = 222/495 (44.85%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPE-SGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY--ILTVWS----IIRQT----------NQARQNLYPNKSSTKSRP--LTQIKITDDSQSIN------ETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHL--NVPTTDMRRSYDFSPKQNLAIKKQSSLID-----KSFQSFNNSFKMSP--TRYGNQLSIR---KNLSNSFRIHKQSRNSAKRTLAAMNS-----GKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTE----WIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYK 1613
L TI+GN LV +SV + KR++ N L SLA +DLL L+VMP+S +++ N+ + + R +C W + DV + +I++LC ISLDRYF + +PLKY TR R ++ W I F + P ++ +P + ++ N + + +K +V + I S + +F LPL +M+ Y I V S ++RQ+ + +Q N T S P T++++ + +N E N +N + S D C DSP S + ++ L N P +++ +N ++ SL D + N ++P ++ Q + R NL H Q K + +KA++ +GI+ F++C++PFF++YL++ F I P+ T W+GYS S+LNPI+Y ++N FR F L+ C +
Sbjct: 4 LLTIFGNILVVLSVVVYKRMRTFTNILLTSLATADLLVGLIVMPMSLLDLLHNHRW-PLGRFLCRMWATSDVLLCTASILNLCVISLDRYFAITSPLKYPRTRSRKMAAGLLTAVWAISFVVCSPPWV---------------IPSWNLFIDNNNNTGSSEDFKCAYSPSVAYRIYSALGSFYLPLLVMLFVYFKIFRVASEREALMRQSVGTCRLSNRLTKTQQKNQRNNLRTASAPHSRTRVQVNHNCGRVNYSVRPVEYANRVENSLKPSHERFDSTDC---------EDSPPNGDSLEAGTTCNISMSLVTNSPPNGLQKE-----AKNSMERECHSLADIVNSADTPVRKNTEVGVAPSLSKRARQCNARLQPNNLLQKAHEHYQINGPGKAVRGSKEKMVYMRERKALKTIGIVVLGFIICWMPFFIMYLVEVF-ISDPVAESPIYRITSEFFLWLGYSNSVLNPIIYTMYNGDFRRCFRDLLSFGCVQ 467
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Match: octr-1 (OCTopamine Receptor (GPCR) [Source:UniProtKB/TrEMBL;Acc:Q7JP61]) HSP 1 Score: 125.176 bits (313), Expect = 9.669e-31 Identity = 114/444 (25.68%), Postives = 203/444 (45.72%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQ-NRFNFFLVSLAISDLLCALLVMPVS-AWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSK-TEWIGYSASMLNPIVYHIFNPTFR 1574
+L + L I+GN LV V+V+ +++L+ R N+ +VSLA++D+L LLVMP++ + +V ++ +C W +LDV F + +I+H+C+ISLDRYF + +PL Y TR + + I ++W++ I P IF R + G S ++ +++ S++ +F +P+ I+I+ Y ++SI +RQ L T+ R T +T I +TN N + Y + D P++ K+ + +N +R+ + P+Q + I + + + P S+ R ++ + KR ++A +LGI+ F+L +LPFF+IY++ F + PLV K W+GY S +NP++Y +FN F+
Sbjct: 28 MLTVMLLIIFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIVGEWTMGNI---LCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVSLLICLPP-IFGWRPERAEGECSVST------------------------DLGYVLYSSLGSFYIPVVILIIVYA-KIYSI--TIRHSRQRL----KETERRDHTLNMLT-----IRSSTNERYN-MEYELEENSD---------------PIEDEKEKVVTNRDM---INKVCWQLRKISEELPRQGVKI------------ALDTNHNSPPA------------SDLTRKLEEKKFCEKRKRKLKAKERQATLLLGIILSAFILSWLPFFLIYVIGAFGHEAP----PLVFKFFFWLGYCNSGINPVIYTVFNREFK 384
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Match: octr-1 (OCTopamine Receptor (GPCR) [Source:UniProtKB/TrEMBL;Acc:Q7JP61]) HSP 1 Score: 125.176 bits (313), Expect = 1.056e-30 Identity = 117/444 (26.35%), Postives = 205/444 (46.17%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQ-NRFNFFLVSLAISDLLCALLVMPVS-AWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSK-TEWIGYSASMLNPIVYHIFNPTFR 1574
+L + L I+GN LV V+V+ +++L+ R N+ +VSLA++D+L LLVMP++ + +V ++ +C W +LDV F + +I+H+C+ISLDRYF + +PL Y TR + + I ++W++ I P IF R + G S ++ +++ S++ +F +P+ I+I+ Y ++SI +RQ L T+ R T +T I +TN N + Y + D P++ K+ + +N +R+ + P+Q + K S +D + S P S+ R ++ + KR ++A +LGI+ F+L +LPFF+IY++ F + PLV K W+GY S +NP++Y +FN F+
Sbjct: 28 MLTVMLLIIFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIVGEWTMGNI---LCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVSLLICLPP-IFGWRPERAEGECSVST------------------------DLGYVLYSSLGSFYIPVVILIIVYA-KIYSI--TIRHSRQRL----KETERRDHTLNMLT-----IRSSTNERYN-MEYELEENSD---------------PIEDEKEKVVTNRDM---INKVCWQLRKISEELPRQGV---KVSIALDTNHNS-------PPA------------SDLTRKLEEKKFCEKRKRKLKAKERQATLLLGIILSAFILSWLPFFLIYVIGAFGHEAP----PLVFKFFFWLGYCNSGINPVIYTVFNREFK 386
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Match: Dop2R (gene:FBgn0053517 transcript:FBtr0343171) HSP 1 Score: 154.066 bits (388), Expect = 9.542e-39 Identity = 128/488 (26.23%), Postives = 221/488 (45.29%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQ-TNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSP---TRYGNQLSI-----------------RKNLSNS-------FRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSK---TEWIGYSASMLNPIVYHIFNPTFRNTFNRLM 1595
D W + L++ P+ T++GN LV +SV E+ LQ N+F+VSLAI+DLL A++VMP + + +V N ++P +C + ++DV ++++I +L +IS+DRY + P+KY + + L I + W I I P+ + L N N P+ C +N FI+ S++ +F +P IM+ Y W+I + ++AR+ + + + L+++ ++I +T A+ + S S P + + S NE + S D + K + + + + M P RYG Q ++ RK+ NS +++HK S+ KR ++ +KA + L I+ G+FL C+LPFF ++D C K + P ++ T W+GY S +NP++Y IFNP FR F ++M
Sbjct: 374 DHNYWALI-LILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVYFLV--NGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIGSPI-VLGLN------NTPNREPDV-----------------CAFYNADFILYSSLSSFYIPCIIMVFLY----WNIFKALRSRARK-----QRAARKPHLSELTGGSVIENIAQTRRLAETALDSS--------------RHASRILPDEAATNTASGSNE-------EEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRFTIYKVHKASKK--KREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 802
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0303603) HSP 1 Score: 125.946 bits (315), Expect = 1.370e-29 Identity = 76/219 (34.70%), Postives = 119/219 (54.34%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP 929
T GN LVC+++ E+RLQN N+FL+SLAI+DL+ A+LVMP+ +V+ + + CL W LDV F + +I+HLC+IS+DRY L P+++ + R + LKI WL+ ++ PL + M N SV L N T C + + ++ +++ F +PL +M++TY LTV + RQ RQNL + + + P
Sbjct: 87 TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKG--YFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSL-------MYSKNHASV-----LVNGT----------CQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQ----RQNLGGGQQTAAATP 277 HSP 2 Score: 75.485 bits (184), Expect = 9.549e-14 Identity = 52/157 (33.12%), Postives = 82/157 (52.23%), Query Frame = 3
Query: 1140 TTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLS-NSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLV-SKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
+T +RRS QN+ + K+ + + SP Q ++R + S NS I SRNS+ R + +KA +VLG++F F++ + PFFV+ LL C +C+ V W+GY++SM+NPI Y IFN FR F +++ C+
Sbjct: 746 STPLRRSATLRSHQNMNYQGAGECGGKTRTTTS-----SPCMLQRQQTVRSHHSRNSSVI---SRNSS-RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0339322) HSP 1 Score: 125.946 bits (315), Expect = 1.370e-29 Identity = 76/219 (34.70%), Postives = 119/219 (54.34%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP 929
T GN LVC+++ E+RLQN N+FL+SLAI+DL+ A+LVMP+ +V+ + + CL W LDV F + +I+HLC+IS+DRY L P+++ + R + LKI WL+ ++ PL + M N SV L N T C + + ++ +++ F +PL +M++TY LTV + RQ RQNL + + + P
Sbjct: 87 TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKG--YFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSL-------MYSKNHASV-----LVNGT----------CQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQ----RQNLGGGQQTAAATP 277 HSP 2 Score: 75.485 bits (184), Expect = 9.549e-14 Identity = 52/157 (33.12%), Postives = 82/157 (52.23%), Query Frame = 3
Query: 1140 TTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLS-NSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLV-SKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
+T +RRS QN+ + K+ + + SP Q ++R + S NS I SRNS+ R + +KA +VLG++F F++ + PFFV+ LL C +C+ V W+GY++SM+NPI Y IFN FR F +++ C+
Sbjct: 746 STPLRRSATLRSHQNMNYQGAGECGGKTRTTTS-----SPCMLQRQQTVRSHHSRNSSVI---SRNSS-RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Match: 5-HT2B (gene:FBgn0261929 transcript:FBtr0330144) HSP 1 Score: 125.561 bits (314), Expect = 1.656e-29 Identity = 76/219 (34.70%), Postives = 119/219 (54.34%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP 929
T GN LVC+++ E+RLQN N+FL+SLAI+DL+ A+LVMP+ +V+ + + CL W LDV F + +I+HLC+IS+DRY L P+++ + R + LKI WL+ ++ PL + M N SV L N T C + + ++ +++ F +PL +M++TY LTV + RQ RQNL + + + P
Sbjct: 87 TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKG--YFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSL-------MYSKNHASV-----LVNGT----------CQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQ----RQNLGGGQQTAAATP 277 HSP 2 Score: 75.0998 bits (183), Expect = 1.121e-13 Identity = 52/157 (33.12%), Postives = 82/157 (52.23%), Query Frame = 3
Query: 1140 TTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLS-NSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLV-SKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
+T +RRS QN+ + K+ + + SP Q ++R + S NS I SRNS+ R + +KA +VLG++F F++ + PFFV+ LL C +C+ V W+GY++SM+NPI Y IFN FR F +++ C+
Sbjct: 746 STPLRRSATLRSHQNMNYQGAGECGGKTRTTTS-----SPCMLQRQQTVRSHHSRNSSVI---SRNSS-RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Match: 5-HT7 (gene:FBgn0004573 transcript:FBtr0334508) HSP 1 Score: 99.7525 bits (247), Expect = 1.399e-21 Identity = 67/198 (33.84%), Postives = 105/198 (53.03%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSA-WNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY 842
LLI+ L T+ GN LVC++V + ++L+ N+ LVSLA+SDL ALLVMP++ + ++ NF + +C W S DV + +I++LC+IS+DRY + PL+Y R + L + I WL CI+ P + + GN E G T+ Q N + I +T+ +F +PL +M+ Y
Sbjct: 169 LLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPL---LCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLL-------ILGNEHED--EEGQ-PICTVCQ-----------NFAYQIYATLGSFYIPLSVMLFVY 342 HSP 2 Score: 61.2326 bits (147), Expect = 1.742e-9 Identity = 34/91 (37.36%), Postives = 49/91 (53.85%), Query Frame = 3
Query: 1371 KKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGP--LVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRKAFSAN 1637
KKA LGI+ F +C+LPFF++ L+ F +TM P L S W+GY+ S+LNPI+Y N FR F ++ +C + N
Sbjct: 450 KKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMREN 536
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Match: drd2a (dopamine receptor D2a [Source:ZFIN;Acc:ZDB-GENE-021119-2]) HSP 1 Score: 154.451 bits (389), Expect = 2.107e-40 Identity = 129/474 (27.22%), Postives = 234/474 (49.37%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGS----FKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN-------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
R+Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+++ C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L N+V L C N F++ S++++F +P I ++ Y+ ++ ++R+ + R N + ++ P+T + D S +I + T+ D + ++I C ++ ++ V G +I+++N P+ ++ +QN + S+L + + + P R GN SI K + +F I + ++ +N KKA Q+L I+ G+F++C+LPFF+ ++++ +C + L + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 29 RHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWILSFAISCPL-LFGL---------NNTVTHDDAL--------------CVIANPAFVVYSSIVSFYVPFIITLLVYV-QIYVVLRK-RRKRVN------TKRTCPVTDM---DMSSTIKKCTHPDDVKLC-TVIVKSSGNCPVNNKNVIFIKEVVNNGDDIQMDEITNRN--------PSRQRKQDQSGGSQQNSRL-VNSNLRETDISPPSPEAGVKPERNGNTSSITKG-AKAFEIQVSPTGKTQTSVKTLNKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYC----QVPPELYTAFTWLGYVNSAVNPIIYTTFNIEFRKAFIKILHC 448
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Match: drd2a (dopamine receptor D2a [Source:ZFIN;Acc:ZDB-GENE-021119-2]) HSP 1 Score: 154.451 bits (389), Expect = 2.107e-40 Identity = 129/474 (27.22%), Postives = 234/474 (49.37%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGS----FKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN-------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
R+Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+++ C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L N+V L C N F++ S++++F +P I ++ Y+ ++ ++R+ + R N + ++ P+T + D S +I + T+ D + ++I C ++ ++ V G +I+++N P+ ++ +QN + S+L + + + P R GN SI K + +F I + ++ +N KKA Q+L I+ G+F++C+LPFF+ ++++ +C + L + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 29 RHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWILSFAISCPL-LFGL---------NNTVTHDDAL--------------CVIANPAFVVYSSIVSFYVPFIITLLVYV-QIYVVLRK-RRKRVN------TKRTCPVTDM---DMSSTIKKCTHPDDVKLC-TVIVKSSGNCPVNNKNVIFIKEVVNNGDDIQMDEITNRN--------PSRQRKQDQSGGSQQNSRL-VNSNLRETDISPPSPEAGVKPERNGNTSSITKG-AKAFEIQVSPTGKTQTSVKTLNKRKISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYC----QVPPELYTAFTWLGYVNSAVNPIIYTTFNIEFRKAFIKILHC 448
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Match: htr1aa (5-hydroxytryptamine (serotonin) receptor 1A a [Source:ZFIN;Acc:ZDB-GENE-071203-1]) HSP 1 Score: 147.517 bits (371), Expect = 2.978e-38 Identity = 125/459 (27.23%), Postives = 203/459 (44.23%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINET--TNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYK 1613
FL LI L I GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + +C + SLDV +++I+HLC+I+LDRY+ + +P+ Y N R + IS+ WLI F I+ P P GW E + D + + I ST F +PL +M+V Y R AR + T+ + KI D +++ A+ +V + P G+ K S E S++ + Q+++ K SL + F N +N N+ K + ++T V+ LGI+ G F+ C+LPFF++ L+ FC C M L + W+GYS S+LNP++Y FN F+N F ++++CKC +
Sbjct: 34 FLAALI--LFAILGNACVIAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQEMCDIFISLDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAILISLTWLIGFSISIP-------------------PMLGWRKPE---DRADPDACTISQDHGYTIYSTFGAFYIPLILMLVLY-------GRIFRAARFRIRKTVKKTE-----KAKIADKCLAVSPALFPRKANGEVGKTW---------------RRSVEPCANGALKNSDDGE--------------SFEITEVQSIS-KNHLSLPNNPQPCFEN----------------RNEKNTEAKRKVALARERKT----------VKTLGIIMGTFIFCWLPFFIVALVLPFCQDC-FMPEWLGAVINWLGYSNSLLNPVIYAYFNKDFQNAFKKILKCKCIR 397
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Match: drd2l (dopamine receptor D2 like [Source:ZFIN;Acc:ZDB-GENE-030910-1]) HSP 1 Score: 146.362 bits (368), Expect = 1.280e-37 Identity = 121/456 (26.54%), Postives = 212/456 (46.49%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAW-NMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRI--RSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAK---RTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L+++ C ++GN LVCV+V EK LQ N+ +VSLA+SDLL A LVMP + +V F+ R C +LDV + +I++LC+IS+DRY + PL Y NTR R + L I++ W + F I+CPL +F L N T SQ+ + C + F++ S+V +F +P + ++ Y+ + ++R+ + ++T+ D+Q + + DV + + +P ++ K++ E +H D P L+ ++ + S ++ S ++P + R++ + H + +AK R + +KA Q+L I+ G+F++C+LPFF+ ++L C C ++ L S W+GY S +NP++Y FN FR F +++ C
Sbjct: 47 LVLLIFCVVFGNVLVCVAVSREKALQTTTNYLIVSLAVSDLLLATLVMPWGVYLEVVGEWRFS---RIHCDVLLTLDVMMCTASILNLCAISIDRYTAVAMPLLY-NTRYSSRRRVALMIAVVWFLSFAISCPL-LFGL--------------------NNTASQE---GRDCSFADPAFVVYSSVASFYVPFIVTLLVYV-QICVVLRRRGRRTAPTRRRAANTEP---------ADAQRTRKNKCTHPEDVKLCTLILKPP-----------AAAPQRK---KVTLVKEAVVH----------PLDVEPVCFLSADREQTQTQPSGRA-KLSLSVAPCAGQSGPGPRRDTLQE-KTHTEKHAAAKERVRGRLSQQKERKATQMLAIVLGVFIICWLPFFLTHVLKAHCGSC-CISPSLYSAVTWLGYLNSAVNPVIYTTFNIEFRKAFIKILHC 437
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Match: drd2l (dopamine receptor D2 like [Source:ZFIN;Acc:ZDB-GENE-030910-1]) HSP 1 Score: 145.976 bits (367), Expect = 2.305e-37 Identity = 121/456 (26.54%), Postives = 212/456 (46.49%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAW-NMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRI--RSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAK---RTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L+++ C ++GN LVCV+V EK LQ N+ +VSLA+SDLL A LVMP + +V F+ R C +LDV + +I++LC+IS+DRY + PL Y NTR R + L I++ W + F I+CPL +F L N T SQ+ + C + F++ S+V +F +P + ++ Y+ + ++R+ + ++T+ D+Q + + DV + + +P ++ K++ E +H D P L+ ++ + S ++ S ++P + R++ + H + +AK R + +KA Q+L I+ G+F++C+LPFF+ ++L C C ++ L S W+GY S +NP++Y FN FR F +++ C
Sbjct: 60 LVLLIFCVVFGNVLVCVAVSREKALQTTTNYLIVSLAVSDLLLATLVMPWGVYLEVVGEWRFS---RIHCDVLLTLDVMMCTASILNLCAISIDRYTAVAMPLLY-NTRYSSRRRVALMIAVVWFLSFAISCPL-LFGL--------------------NNTASQE---GRDCSFADPAFVVYSSVASFYVPFIVTLLVYV-QICVVLRRRGRRTAPTRRRAANTEP---------ADAQRTRKNKCTHPEDVKLCTLILKPP-----------AAAPQRK---KVTLVKEAVVH----------PLDVEPVCFLSADREQTQTQPSGRA-KLSLSVAPCAGQSGPGPRRDTLQE-KTHTEKHAAAKERVRGRLSQQKERKATQMLAIVLGVFIICWLPFFLTHVLKAHCGSC-CISPSLYSAVTWLGYLNSAVNPVIYTTFNIEFRKAFIKILHC 450
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Match: DRD2 (dopamine receptor D2 [Source:NCBI gene;Acc:100493063]) HSP 1 Score: 150.984 bits (380), Expect = 4.711e-39 Identity = 131/479 (27.35%), Postives = 220/479 (45.93%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQ------TNQARQNLYPNKSSTKSRPLTQIKI------------TDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
Y + + L ++ ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ R C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L NN S K C N F+I S++++F +P + ++ Y+ ++ ++R+ T + + N K +K+ TD + ++E N + D+ M+ SP ++ K + N L VP T + + P S +D +++ N T+ I+ + R + +KR L + + KKA Q+L I+ G+F++C+LPFF+I++L+ C C + L S W+GY S +NPI+Y FN FR F +++ C
Sbjct: 27 HYNYYAMLLTLLIFVIVFGNVLVCIAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYMEVVGEWRFS---RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWVLSFAISCPL-LFGL-------NNTAS-------------------KVCIIDNPAFVIYSSIVSFYVPFIVTLLVYV-QIYIVLRKRRKRVNTKRNSHGVEVNAHKDKCTHPEDVKLCAVFVKSNGSFPTDKKKVVSEAGNHPE-DMDVEMMS---------------STSPPEKTKHKSASPNHH--QLAVPATSNQCNNANLP----------SPVDSPYKAEKNGHPKDSTKPAKVFEIQTMPNGKTR--TSIKTMSKRKL-SQHKEKKATQMLAIVLGVFIICWLPFFIIHILNMHC-NCN-IPQALYSAFTWLGYVNSAVNPIIYTTFNVEFRKAFIKILHC 440
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797]) HSP 1 Score: 137.117 bits (344), Expect = 4.547e-34 Identity = 79/220 (35.91%), Postives = 119/220 (54.09%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNL 896
WP L + + L TI GN LV ++V +EK+LQN N+FL+SLAI+D+L LVMPVS N++ + + + R +C W LDV F++ +I+HLC+ISLDRY + NP+ + R+ KI W I I+ P+ +F L+ D + N C + FIII + + F +PL IM++TY LT+ S+ ++ NL
Sbjct: 67 WPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLNILNDYEW-PLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAKIIAVWTISVGISMPVPVFGLQDDSKVFDQEN----------------------CSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSLQKEATLCINNL 263 HSP 2 Score: 77.411 bits (189), Expect = 2.306e-14 Identity = 35/105 (33.33%), Postives = 69/105 (65.71%), Query Frame = 3
Query: 1314 IHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
+ K+ ++T+ ++++ +KA +VLGI+F LF++ + PFF+ ++ FC + + + G L+ WIGY +S +NP+VY +FN T+R+ F+R ++C+ + +K
Sbjct: 290 LQKELAPYGRKTMQSISNEQKASKVLGIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSAFSRYIQCRYREEKK 394
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797]) HSP 1 Score: 136.732 bits (343), Expect = 5.202e-34 Identity = 79/220 (35.91%), Postives = 119/220 (54.09%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNL 896
WP L + + L TI GN LV ++V +EK+LQN N+FL+SLAI+D+L LVMPVS N++ + + + R +C W LDV F++ +I+HLC+ISLDRY + NP+ + R+ KI W I I+ P+ +F L+ D + N C + FIII + + F +PL IM++TY LT+ S+ ++ NL
Sbjct: 60 WPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLNILNDYEW-PLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAKIIAVWTISVGISMPVPVFGLQDDSKVFDQEN----------------------CSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSLQKEATLCINNL 256 HSP 2 Score: 77.411 bits (189), Expect = 2.339e-14 Identity = 35/105 (33.33%), Postives = 69/105 (65.71%), Query Frame = 3
Query: 1314 IHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
+ K+ ++T+ ++++ +KA +VLGI+F LF++ + PFF+ ++ FC + + + G L+ WIGY +S +NP+VY +FN T+R+ F+R ++C+ + +K
Sbjct: 283 LQKELAPYGRKTMQSISNEQKASKVLGIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSAFSRYIQCRYREEKK 387
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797]) HSP 1 Score: 137.117 bits (344), Expect = 5.347e-34 Identity = 79/220 (35.91%), Postives = 119/220 (54.09%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNL 896
WP L + + L TI GN LV ++V +EK+LQN N+FL+SLAI+D+L LVMPVS N++ + + + R +C W LDV F++ +I+HLC+ISLDRY + NP+ + R+ KI W I I+ P+ +F L+ D + N C + FIII + + F +PL IM++TY LT+ S+ ++ NL
Sbjct: 69 WPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLNILNDYEW-PLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAKIIAVWTISVGISMPVPVFGLQDDSKVFDQEN----------------------CSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSLQKEATLCINNL 265 HSP 2 Score: 77.411 bits (189), Expect = 2.265e-14 Identity = 35/105 (33.33%), Postives = 69/105 (65.71%), Query Frame = 3
Query: 1314 IHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
+ K+ ++T+ ++++ +KA +VLGI+F LF++ + PFF+ ++ FC + + + G L+ WIGY +S +NP+VY +FN T+R+ F+R ++C+ + +K
Sbjct: 292 LQKELAPYGRKTMQSISNEQKASKVLGIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSAFSRYIQCRYREEKK 396
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Match: slc25a29 (solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 [Source:Xenbase;Acc:XB-GENE-5763797]) HSP 1 Score: 137.117 bits (344), Expect = 5.847e-34 Identity = 79/220 (35.91%), Postives = 119/220 (54.09%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNL 896
WP L + + L TI GN LV ++V +EK+LQN N+FL+SLAI+D+L LVMPVS N++ + + + R +C W LDV F++ +I+HLC+ISLDRY + NP+ + R+ KI W I I+ P+ +F L+ D + N C + FIII + + F +PL IM++TY LT+ S+ ++ NL
Sbjct: 89 WPALLTVTVILVTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLNILNDYEW-PLHRKLCPVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKALAKIIAVWTISVGISMPVPVFGLQDDSKVFDQEN----------------------CSLSDENFIIIGSFVAFFIPLIIMVITYFLTIKSLQKEATLCINNL 285 HSP 2 Score: 77.411 bits (189), Expect = 2.300e-14 Identity = 35/105 (33.33%), Postives = 69/105 (65.71%), Query Frame = 3
Query: 1314 IHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
+ K+ ++T+ ++++ +KA +VLGI+F LF++ + PFF+ ++ FC + + + G L+ WIGY +S +NP+VY +FN T+R+ F+R ++C+ + +K
Sbjct: 312 LQKELAPYGRKTMQSISNEQKASKVLGIVFFLFVIMWCPFFITNVMAVFCKESCNEHVIGELLKVFVWIGYLSSAVNPLVYTLFNQTYRSAFSRYIQCRYREEKK 416
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Match: Drd3 (dopamine receptor D3 [Source:MGI Symbol;Acc:MGI:94925]) HSP 1 Score: 147.132 bits (370), Expect = 8.596e-38 Identity = 124/459 (27.02%), Postives = 205/459 (44.66%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN--NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS---LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRP-LTQIKITDDSQSINETTNSAD--NDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L I+GN LVC +V E+ LQ N+ +VSLA++DLL A LVMP + V NF+ R C + +LDV + +I++LC+IS+DRY + P+ Y + +SS + L I+ W++ F ++CPL G N P +SN F+I S+V++F +P + ++ Y ++ ++RQ + R N RP Q I + + A +D + M ++DK P K +SH + +++R Y +I + ++L +F+ ++ TR ++ LS R R S L + KKA Q++ I+ G F++C+LPFF+ ++L+ C C ++ L T W+GY S LNP++Y FN FR F +++ C
Sbjct: 41 LAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF---------GFNTTGDPSICSISNPD-----------------FVIYSSVVSFYVPFGVTVLVYA-RIYMVLRQRRRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDK------------PYPQKCQDPLLSHLQPLSPGQT--HGELKRYY--------SICQDTALRHPNFEGGGGMSQVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACH-VSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 446
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Match: Drd3 (dopamine receptor D3 [Source:MGI Symbol;Acc:MGI:94925]) HSP 1 Score: 146.747 bits (369), Expect = 2.001e-37 Identity = 127/469 (27.08%), Postives = 209/469 (44.56%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN--NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS---LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQ----ARQNL--------YPNKSST-KSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L I+GN LVC +V E+ LQ N+ +VSLA++DLL A LVMP + V NF+ R C + +LDV + +I++LC+IS+DRY + P+ Y + +SS + L I+ W++ F ++CPL G N P +SN F+I S+V++F +P + ++ Y ++ ++RQ + RQN +P +SS + P+ Q I S D + M ++DK P K +SH + +++R Y +I + ++L +F+ ++ TR ++ LS R R S L + KKA Q++ I+ G F++C+LPFF+ ++L+ C C ++ L T W+GY S LNP++Y FN FR F +++ C
Sbjct: 73 LAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFS---RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF---------GFNTTGDPSICSISNPD-----------------FVIYSSVVSFYVPFGVTVLVYA-RIYMVLRQRRRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLS----------DATGQMEHIEDK------------PYPQKCQDPLLSHLQPLSP--GQTHGELKRYY--------SICQDTALRHPNFEGGGGMSQVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACH-VSPELYRATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 478
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Match: Htr1a (5-hydroxytryptamine (serotonin) receptor 1A [Source:MGI Symbol;Acc:MGI:96273]) HSP 1 Score: 141.739 bits (356), Expect = 4.279e-36 Identity = 123/458 (26.86%), Postives = 204/458 (44.54%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSI---IRQTNQARQNLYPNKS-STKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S + + + I ST F +PL +M+V Y + IR+T + + S T S P +S+N S D S V +P G+ + +++ T+ + ++ R + K +L + +S T Y RKN + K + ++T+ + LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSNPNECTIS---KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAP-------PPKKSLNGQPGSGDCRRSAENRAVG---------------TPCANGAVR-QGEDDATLEV----IEVHRVGN--SKGHLPLPSES----------------GATSYVPACLERKNERTAEAKRKMALARERKTV----------KTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Match: Drd2 (dopamine receptor D2 [Source:MGI Symbol;Acc:MGI:94924]) HSP 1 Score: 140.198 bits (352), Expect = 2.611e-35 Identity = 130/482 (26.97%), Postives = 217/482 (45.02%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLC--TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKIS--------HKNEFTIHLNVPTTDMRRS-YDFSPKQNLAIKKQSSLIDKSFQSF--NNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMN-------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
DR + + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ R C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + I+I W++ F I+CPL +F L NN + NE C N F++ S++++F +P + ++ YI ++ ++R + R+ + +SS R + + + D K C+ GSF ++ E + + T+ R+ Y P + Q +L D S N P + G+ + ++ F I + +L M+ KKA Q+L I+ G+F++C+LPFF+ ++L+ C C + L S W+GY S +NPI+Y FN FR F +++ C
Sbjct: 30 DRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS---RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMIAIVWVLSFTISCPL-LFGL-------NNTD--------QNE-----------CIIANPAFVVYSSIVSFYVPFIVTLLVYI-KIYIVLR---KRRKRVNTKRSSRAFRANLKTPLKGNCTHPE-----------------DMKLCTVIMK---------SNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSH----HQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCN-IPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC 444
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Match: Htr2c (5-hydroxytryptamine (serotonin) receptor 2C [Source:MGI Symbol;Acc:MGI:96281]) HSP 1 Score: 140.198 bits (352), Expect = 2.831e-35 Identity = 79/213 (37.09%), Postives = 126/213 (59.15%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQT 875
WP L +++I + TI GN LV ++V +EK+L N N+FL+SLAI+D+L LLVMP+S ++ + + +PR +C W SLDV F++ +I+HLC+ISLDRY + NP+++ R+ +KI+I W I ++ P+ + LR ES N T C ++ F++I + + F +PL IM++TY LT++ + RQT
Sbjct: 56 WPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW-PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLR------------DESKVFVNNT---------TCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQT 246 HSP 2 Score: 73.9442 bits (180), Expect = 2.132e-13 Identity = 39/94 (41.49%), Postives = 59/94 (62.77%), Query Frame = 3
Query: 1347 TLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
T+ A+N+ KKA +VLGI+F +FL+ + PFF+ +L C K Q + L++ WIGY S +NP+VY +FN +R F++ +RC YK K
Sbjct: 300 TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCD-YKPDK 392
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Match: sp|P19327|5HT1A_RAT (5-hydroxytryptamine receptor 1A OS=Rattus norvegicus OX=10116 GN=Htr1a PE=1 SV=1) HSP 1 Score: 152.91 bits (385), Expect = 3.678e-39 Identity = 128/455 (28.13%), Postives = 209/455 (45.93%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTN-QARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S D+ H + I ST F +PL +M+V Y I R + R+ + + L +S+N S D + C + +P G+ + +E T+ + ++ R + K++L + +S +NS Y RKN N+ AKR + A+ +K V+ LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSDP-DACTISKDHG--YTIYSTFGAFYIPLLLMLVLY----GRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDW-----------RRC----AENRAVGTPCTNGAVR-QGDDEATLEV----IEVHRVGN--SKEHLPLPSESG---------SNS-------YAPACLERKNERNA---------EAKRKM-ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Match: sp|Q9N298|5HT1A_PANTR (5-hydroxytryptamine receptor 1A OS=Pan troglodytes OX=9598 GN=HTR1A PE=3 SV=1) HSP 1 Score: 151.369 bits (381), Expect = 1.391e-38 Identity = 124/456 (27.19%), Postives = 208/456 (45.61%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTK--SRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S D+ H + I ST F +PL +M+V Y + + + + + + T+ + P Q K +S+N + S + +GV+ K G+ +R+ D + + + + + + S + + PT RKN N+ AKR + A+ +K V+ LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSDP-DACTISKDHG--YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAQQPK-----KSVNGESGSRN-----WRLGVESK----------------AGGAL-------------CANGAVRQGDDGAALEVIEVHR----VGNSKEHLPLPSEAGPTPCAPASFERKNERNA---------EAKRKM-ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Match: sp|P08908|5HT1A_HUMAN (5-hydroxytryptamine receptor 1A OS=Homo sapiens OX=9606 GN=HTR1A PE=1 SV=3) HSP 1 Score: 150.984 bits (380), Expect = 1.675e-38 Identity = 124/456 (27.19%), Postives = 208/456 (45.61%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTK--SRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S D+ H + I ST F +PL +M+V Y + + + + + + T+ + P Q K +S+N + S + +GV+ K G+ +R+ D + + + + + + S + + PT RKN N+ AKR + A+ +K V+ LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSDP-DACTISKDHG--YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPK-----KSVNGESGSRN-----WRLGVESK----------------AGGAL-------------CANGAVRQGDDGAALEVIEVHR----VGNSKEHLPLPSEAGPTPCAPASFERKNERNA---------EAKRKM-ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Match: sp|Q9N297|5HT1A_GORGO (5-hydroxytryptamine receptor 1A OS=Gorilla gorilla gorilla OX=9595 GN=HTR1A PE=3 SV=1) HSP 1 Score: 150.984 bits (380), Expect = 1.865e-38 Identity = 124/456 (27.19%), Postives = 208/456 (45.61%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTK--SRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
LG LI C + GNA V ++ +E+ LQN N+ + SLA++DL+ ++LV+P++A V N ++ + C + +LDV +++I+HLC+I+LDRY+ + +P+ Y N R IS+ WLI F I+ P P GW + E S D+ H + I ST F +PL +M+V Y + + + + + + T+ + P Q K +S+N + S + +GV+ K G+ +R+ D + + + + + + S + + PT RKN N+ AKR + A+ +K V+ LGI+ G F+LC+LPFF++ L+ FC M L + W+GYS S+LNP++Y FN F+N F ++++CK
Sbjct: 42 LLGTLI--FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK--WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIP-------------------PMLGWRTPEDRSDP-DACTISKDHG--YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPK-----KSVNGESGSRN-----WRLGVESK----------------AGGAL-------------CANGAVRQGDDGAALEVIEVHR----VGNSKEHLPLPSEAGPTPCAPASFERKNERNA---------EAKRKM-ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCK 418
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Match: sp|Q17232|OAR_BOMMO (Octopamine receptor OS=Bombyx mori OX=7091 PE=2 SV=1) HSP 1 Score: 150.214 bits (378), Expect = 9.860e-38 Identity = 125/460 (27.17%), Postives = 226/460 (49.13%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVS-AWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYI-LTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIH-LNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKM---SPTRYGNQLSIRKNLSNSFR--IHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKC 1607
L +I + T+ GN LV +SVF K L+ NFF+VSLA++DL A+LV+P++ A++++ F +C W + D+ +++I++LC+I+LDRY+ + +P+ Y R + I I W++ I+ P + N PE + +L S G F+I S+ +F +PL IM V Y + + + R ++A+ SS +++ T+ +D S++ N ++ ++ ++K +P K+ + K++ + + L +P S +NL + SS + +N ++ +P + Q ++N +N+ I ++ R S R ++A + LGI+ G+F++C+LPFFVIYL+ FC+ C ++ ++ W+GY S LNP++Y IFN FR F +L+ KC
Sbjct: 61 LTMIIISTVVGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVAILVLPLNVAYSILGQWVFGIY---VCKMWLTCDIMCCTSSILNLCAIALDRYWAITDPINYAQKRTLERVLFMIGIVWILSLVISSPPLL-----------GWNDWPE---VFEPDTPCRLTSQPG-------FVIFSSSGSFYIPLVIMTVVYFEIYLATKKRLRDRAKATKISTISSGRNKYETKESDPNDQDSVSSDANPNEHQGGTRLVAENEK------KHRTRKLTPKKKPKRRYWSKDDKSHNKLIIPILSNENSVT-DIGENLENRNTSSESNSKETHEDNMIEITEAAPVKI--QKRPKQNQTNAVYQFIEEKQRISLTRE-------RRAARTLGIIMGVFVVCWLPFFVIYLVIPFCVSC-CLSNKFINFITWLGYVNSALNPLIYTIFNMDFRRAFKKLLFIKC 479
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Match: A0A193KUM1 (GCR037 OS=Schmidtea mediterranea OX=79327 GN=gcr037 PE=2 SV=1) HSP 1 Score: 374.015 bits (959), Expect = 1.963e-119 Identity = 215/488 (44.06%), Postives = 301/488 (61.68%), Query Frame = 3
Query: 234 QWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSI--RKNLSNSFRIHKQSRNSAKR-------------------------TLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKV 1616
+W FL LL+IP+ TI+GN LV VSV++EKRLQNRFN+FLVSLA+SD LCA+LVMPVS MV + P +CLAWYSLDVFFT+TTIIHLC+IS+DRY LNNPL++H T+ + SL +KISI+WLIPF IACPLF+ +L++ ET++Q+ S+KGCGP+N FI+ + ++TF+LPL IM+++YILTV +I +QT + + KSR +Q +I S ++ S++ V+ K C + SLN + S S ++ + + N PTT + ++N+ K++ F+ +R Q+SI RK N+ R+H+ S +++R +L + +KAVQVLGI+FGLF+ CY+PFFVIYL DFFC+ C+++T ++S +EWIGYSASM+NP+VYHIFNPTFR TFNRL+RC+CYKV
Sbjct: 28 KWAFLFLLLIPIITIFGNILVGVSVYLEKRLQNRFNYFLVSLAVSDFLCAILVMPVSTVKMVHVDLTNGWPHQLCLAWYSLDVFFTATTIIHLCTISIDRYVALNNPLRFHQTKRKYSLFIKISISWLIPFGIACPLFLSSLKI-------------------ETMNQEESSFKGCGPNNAIFIMTAVIVTFILPLLIMMISYILTVKTIRKQTKNL--DSFSTNGHRKSR-FSQSEIYKKSM--------PSTSLTTSILNVNSKVCDDLNHSLNQEKLSLLSISTDFSRRSLMSCN-NFPTTPSK------IQENIDGDKETYF----------DFRGKFSRLSRQMSIPFRK---NTLRLHRNSSVNSERLRLCANVLLNSRLSVNSRRIATSDLSLRYIQKSRKAVQVLGIVFGLFVCCYMPFFVIYLTDFFCVSCKSITSWMISYSEWIGYSASMMNPVVYHIFNPTFRRTFNRLIRCRCYKV 465
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Match: A0A193KU74 (GCR027 OS=Schmidtea mediterranea OX=79327 GN=gcr027 PE=2 SV=1) HSP 1 Score: 340.887 bits (873), Expect = 2.414e-106 Identity = 190/502 (37.85%), Postives = 279/502 (55.58%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSST------KSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKI------SHKNEFTIHLNV---------PTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQ---------------SFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKV 1616
RY W ++GL IIP+ ++WGN+LVC+SV++E L+ RFN+FLVSLA+SD LCA+LVMP+SAW M+ N ++ CL WYSLDVFFT++TIIHLC+IS+DRY L NPLK H + SL +++ AW+IPF IACPLF+FAL LD +++ S+KGCGP N YFI+I+T++TF +PL IM VTY+LTV + Q +A NLY N ++ S L + T ++ ++E + N+ S +M + + F F++ + +N F + ++ P + P++ ++ ++Q + ++ S SFKMS K ++ + + ++ L +N +KAVQ LGILF LF++CYLPFFV YL+DFF C + +++ EW+GYS SM NPIVYH FNP FR+T+ RLM+C+CY+V
Sbjct: 15 SRYNWAYVGLFIIPMLSMWGNSLVCISVWVEVGLRKRFNYFLVSLAMSDFLCAILVMPISAWKMIDNYYLETINHQWCLIWYSLDVFFTASTIIHLCTISIDRYNALKNPLKIHGQKRYRSLVVQLVCAWIIPFSIACPLFLFALELDK--------------------TREHSSFKGCGPQNAYFILIATIVTFFIPLIIMTVTYVLTVKILYVQRKEAEANLYSNAVASLVFKPKLSSSLAKFTRTPSTKVMSEKKLNGKNENSSAMHRRSISTSCLVNSLDSEFKETENHNHFEMTPLLAKTTRNNFVENTSMNLCGSDNLKPPLQEDQYKQTLPQRQVSFREQQKTKNHYWKSNTVCTVLENPLALLSHQRSFKMS----------NKTKTDEYSAFYTKKKETEKQLKQINRSRKAVQTLGILFLLFVICYLPFFVAYLVDFFFKICSVSSTAEKMLTFLEWMGYSGSMFNPIVYHFFNPIFRHTYQRLMKCQCYRV 486
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Match: A0A4S2M3D3 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_002997 PE=3 SV=1) HSP 1 Score: 298.13 bits (762), Expect = 6.565e-90 Identity = 193/491 (39.31%), Postives = 278/491 (56.62%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMV--RNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNT--RIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQ-NLYPNKSSTKSRPLTQIKI----TDDSQSINETTNS-------ADNDVSY---------SMIGVDDKYCXXXXXX--XXXXXXPVKRGSFKI-------SHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLA--AMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKC 1607
++ L +IPL TIWGN VC++V++E+RL++RFN FLVSLAISDLLCA+LVMPVSAW+M+ R N R +CL YS+D+FFT+TTIIHLCSISLDRY L P + +I SL L+I ++W +PF IA PLF+FAL+ + G+ +V + +N TIS+ SYKGCGP++ F++ + +TFVLPL IM TY+LTV + R Q + LY +T+ RP++ + D+S ET S D + S G D+K SLS L+ + P ++ +I S ++E ++ N + D S Q IK +L S ++ G +LS L + + +SA+ T A ++SGK+AV+V+ +LFGLF+ CY PFF++Y + C +C++ P + EW+GY SMLNP+VYH FN TFR TF R+++C C
Sbjct: 9 YIALCLIPLGTIWGNICVCLAVYMERRLRHRFNLFLVSLAISDLLCAILVMPVSAWHMIATRPQN-----RILCLVSYSMDIFFTATTIIHLCSISLDRYLALRRPFGRNRALPKIFQSLVLRIFMSWFVPFSIAGPLFVFALKWER--GDEEFNVTMTPEAANITISK---SYKGCGPNDKSFVLTAIGVTFVLPLIIMTATYVLTVKMLRRHMAQVKAIQLY----ATRPRPVSTSSVLWLRRDNSFRPTETNRSTKAWFRQTDQQTTIPKTAKYMPPSDCGCDEKTVKTCSLSDPLSYHNRPAEKPRTRIPIGVENPSTQDEASLSGN--RVSGKDPSDRSNDQQSYIKASETLFLTSTAKTDHDIS------GLELSSNHELGLPSQGRRTDISSAQTTTAIDRIHSGKRAVRVIAVLFGLFVTCYTPFFIVYTISVVCPQCRSWAEPAIPHLEWLGYLNSMLNPVVYHSFNSTFRRTFRRILQCAC 477
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Match: A0A1S8WK07 (7 transmembrane receptor (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_09436 PE=3 SV=1) HSP 1 Score: 291.967 bits (746), Expect = 1.436e-87 Identity = 189/487 (38.81%), Postives = 271/487 (55.65%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMV--RNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNT--RIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQ-NLYPNKSSTKSRPLTQIKI----TDDS---QSINETTNS----ADNDVSY----SMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISH-KNEFTIHLNVPTTDMRRSY--------DFSPKQNLAIKKQSSLIDKSFQSF-NNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLA--AMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKC 1607
++ L +IPL TIWGN VC++V++E+RL++RFN FLVSLAISDLLCA+LVMPVSAW+M+ R N R +CL YS+D+FFT+TTIIHLCSISLDRY L P + +I SL +I ++W +PF IA PLF+FAL+ + G+ V + +N T S+ SYKGCGP++ F++ + +TFVLPL IM TY+LTV + R Q + LY +T+ RP++ + D+S IN +T + AD + + D C ++ S P+ + + I + P+T S D S K N Q S + S F ++ K G +LS L + + +SA+ T A ++SGK+AV+V+ +LFGLF+ CY PFF++Y + C +C++ P + EW+GY SMLNP+VYH FN TFR TF R+ +C C
Sbjct: 9 YIALCLIPLGTIWGNICVCLAVYLERRLRHRFNLFLVSLAISDLLCAILVMPVSAWHMIATRPQN-----RILCLVSYSMDIFFTATTIIHLCSISLDRYLALRRPFGRNRAVPKIFQSLVFRIFMSWFVPFSIAGPLFVFALKWER--GDEEFIVTMTPESANITTSK---SYKGCGPNDKSFVLTAIGVTFVLPLIIMTATYVLTVKMLRRHMAQVKAIQLY----ATRPRPVSTSSVLWLRRDNSFRPTEINRSTKAWFRQADQQSTIPKTTKYMPASDSGCDEKTVKTCSLSDPLSYHNRPAENPPRRIPIGVENPSTQDEASLSGNRVCGKDPSDKSN----DQQSYVKASETLFLTSTAKNDHDISGLELSSNHELGLPSQGRRTDISSAQTTTAIDRIHSGKRAVRVIAVLFGLFVTCYTPFFIVYTISVVCPQCRSWAEPAIPHLEWLGYLNSMLNPVVYHSFNSTFRRTFRRIFQCAC 477
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Match: A0A074ZZH1 (G_PROTEIN_RECEP_F1_2 domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_02329 PE=3 SV=1) HSP 1 Score: 291.582 bits (745), Expect = 1.932e-87 Identity = 189/487 (38.81%), Postives = 271/487 (55.65%), Query Frame = 3
Query: 243 FLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMV--RNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNT--RIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQ-NLYPNKSSTKSRPLTQIKI----TDDS---QSINETTNS----ADNDVSY----SMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISH-KNEFTIHLNVPTTDMRRSY--------DFSPKQNLAIKKQSSLIDKSFQSF-NNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLA--AMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKC 1607
++ L +IPL TIWGN VC++V++E+RL++RFN FLVSLAISDLLCA+LVMPVSAW+M+ R N R +CL YS+D+FFT+TTIIHLCSISLDRY L P + +I SL +I ++W +PF IA PLF+FAL+ + G+ V + +N T S+ SYKGCGP++ F++ + +TFVLPL IM TY+LTV + R Q + LY +T+ RP++ + D+S IN +T + AD + + D C ++ S P+ + + I + P+T S D S K N Q S + S F ++ K G +LS L + + +SA+ T A ++SGK+AV+V+ +LFGLF+ CY PFF++Y + C +C++ P + EW+GY SMLNP+VYH FN TFR TF R+ +C C
Sbjct: 9 YIALCLIPLGTIWGNICVCLAVYLERRLRHRFNLFLVSLAISDLLCAILVMPVSAWHMIATRPQN-----RILCLVSYSMDIFFTATTIIHLCSISLDRYLALRRPFGRNRAVPKIFQSLVFRIFMSWFVPFSIAGPLFVFALKWER--GDEEFIVTMTPESANITTSK---SYKGCGPNDKSFVLTAIGVTFVLPLIIMTATYVLTVKMLRRHMAQVKAIQLY----ATRPRPVSTSSVLWLRRDNSFRPTEINRSTKAWFRQADQQSTIPKTTKYMPASDSGCDEKTVKTCSLSDPLSYHNRPAENPPRRIPIGVENPSTQDEASLSGNRVCGKDPSDKSN----DQQSYVKASETLFLTSTAKNDHDISGLELSSNHELGLPSQGRRTDISSAQTTTAIDRIHSGKRAVRVIAVLFGLFVTCYTPFFIVYTISVVCPQCRSWAEPAIPHLEWLGYLNSMLNPVVYHSFNSTFRRTFRRIFQCAC 477
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Match: drd2a (D(2)-like dopamine receptor [Source:NCBI gene;Acc:103036974]) HSP 1 Score: 143.28 bits (360), Expect = 1.505e-36 Identity = 127/483 (26.29%), Postives = 220/483 (45.55%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRI--RSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIK-------KQSSLIDKSFQSFNNSF------KMSPTRYGN-------QLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
++Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+++ C + +LDV + +I++LC+IS+DRY + P+ Y NTR R + + IS+ W++ F I+CPL +F L NN S ++ C N F++ S++++F +P I ++ Y+ ++ ++R+ + SST R T K T D K C+ G+F +++KN I V D ++ + + + L + Q L+ S S + P+R GN + +S S + ++ KR + KKA Q+L I+ G+F++C+LPFF+ ++++ + + L + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 29 KHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSTIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSRRRVTVMISVVWILSFAISCPL-LFGL-------NNTESRDDA----------------LCVIANPAFVVYSSIVSFYVPFIITLLVYV-QIYVVLRKRRKRVSTKRTFPSSTAERGTTLKKCTHPD---------------------DVKLCTVIVK---------SNGNFPVNNKNVIFIKEVVNNADDVQADEVTNPEPLNQRTLEQTGASQHGLLLVSTHSETEVLPTVPEAPIKPSRNGNTGDAPRVTKAFETQVSPSGKTQSSVKSFNKRKFSQQKE-KKATQMLAIVLGVFIICWLPFFITHIVNTY----YNVPAELYTAFTWLGYVNSAVNPIIYTTFNIEFRKAFIKILHC 447
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621]) HSP 1 Score: 142.51 bits (358), Expect = 3.388e-36 Identity = 120/471 (25.48%), Postives = 224/471 (47.56%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNV-PTTDMRRSYDFSPKQNLAIKK---QSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLA----AMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
++Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ + C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L NN + +S C N F++ S++++F +P I ++ Y+ ++ ++R+ + R N N + P +K + T+ D + ++ + + + V+ G+ E + + P M+ + P NL + +S + + +Q ++ K + K+ + ++R + +T++ + + KKA Q+L I+ G+F++C+LPFF+ ++L C C + + + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 29 KHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWVLSFAISCPL-LFGL-------NNTATRDDS----------------VCEIANPAFVVYSSIMSFYVPFIITLLVYV-QIYVVLRK-RRKRVNTKRNCQKADAEPQPPLK--------EKCTHPEDVKLCTVIVKTNGSLPVKNKKAQLLIKEVVQPGT-----GVEMGLMTSTSPPEKMKLAA--PPAVNLLATQSPSHASPLHEEWQPHDDE-KNGHAKDAQTPKETKSFETQALPNGKTRTTVTKTMSKRKMSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCY-VPLEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFMKILHC 452
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621]) HSP 1 Score: 141.739 bits (356), Expect = 5.586e-36 Identity = 121/471 (25.69%), Postives = 221/471 (46.92%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQS----SLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLA----AMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
++Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ + C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L N T ++ DS C N F++ S++++F +P I ++ Y+ ++ ++R+ + R N N + P +K + T+ D + ++ + PVK + + L T+ + +P + QS S + + +Q ++ K + K+ + ++R + +T++ + + KKA Q+L I+ G+F++C+LPFF+ ++L C C + + + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 23 KHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWVLSFAISCPL-LFGL--------------------NNTATRD-DSV--CEIANPAFVVYSSIMSFYVPFIITLLVYV-QIYVVLRK-RRKRVNTKRNCQKADAEPQPPLK--------EKCTHPEDVKLCTVIVKTNGS-------------LPVKNKKV-VQPGTGVEMGLMTSTSPPEKMKLAAPPAVNLLATQSPSHASPLHEEWQPHDDE-KNGHAKDAQTPKETKSFETQALPNGKTRTTVTKTMSKRKMSQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCY-VPLEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFMKILHC 439
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Match: drd2b (D(2) dopamine receptor A [Source:NCBI gene;Acc:103035621]) HSP 1 Score: 140.198 bits (352), Expect = 1.341e-35 Identity = 123/463 (26.57%), Postives = 219/463 (47.30%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPL--CTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMP-VSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSS--LPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
++Q+ + +L+ L ++GN LVC++V EK LQ N+ +VSLA++DLL A LVMP V +V F+ + C + +LDV + +I++LC+IS+DRY + P+ Y NTR S + + IS+ W++ F I+CPL +F L NN + +S C N F++ S++++F +P I ++ Y+ ++ ++R+ + R N N + P +K + + T ++ + K + +++L + SP SH + P + + +D K A Q+ KSF++ + L N ++ +KR + + + KKA Q+L I+ G+F++C+LPFF+ ++L C C + + + W+GY S +NPI+Y FN FR F +++ C
Sbjct: 29 KHQYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIH---CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY-NTRYSSKRRVTVMISVVWVLSFAISCPL-LFGL-------NNTATRDDS----------------VCEIANPAFVVYSSIMSFYVPFIITLLVYV-QIYVVLRK-RRKRVNTKRNCQKADAEPQPPLKQLLIKEVVQPGTGVEMGLMTSTSPPEKMKLAAPPAVNLLATQSP--------SHAS--------PLHEEWQPHD-DEKNGHAKDAQTPKETKSFET-------------------QALPNGKTRTTVTKTMSKRKM-SQHKEKKATQMLAIVLGVFIICWLPFFITHILKTHCTSCY-VPLEMYNAFTWLGYVNSAVNPIIYTTFNVEFRKAFMKILHC 423
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Match: drd3 (dopamine receptor D3 [Source:NCBI gene;Acc:103024755]) HSP 1 Score: 140.969 bits (354), Expect = 1.363e-35 Identity = 123/459 (26.80%), Postives = 208/459 (45.32%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTR-IRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQS-INETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIR----KNLSNSFRIHK--------QSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
L ++GN LVC++V EK LQ N+ +VSLA+SDLL A LVMP + + V + R C + +LDV + +I++LC+IS+DRY + P+ Y+ T R + + I+ W++ F ++CPL G N P C N F+I S+V++F LP + ++ Y+ ++ +R+ R+ + ++S + + Q +++ + E T D+S I V ++ ++ + +N +P D+ QN Q+S + + +Q+++R K +SN R H +R S R + + KKA Q+L I+ G+FL+C+LPFFV ++L+ C C + L S W+GY S LNP++Y FN FR F +++ C
Sbjct: 66 LAIVFGNVLVCMAVLREKSLQTTTNYLVVSLAVSDLLVASLVMPWAVYLEVVGGAWL-FSRLYCNIFVTLDVMMCTASILNLCAISIDRYTAVVMPVLYNTTHSSRKRVSVMIATVWILAFAVSCPLLF---------GFNTTDDP-----------------LVCSISNPDFVIYSSVVSFYLPFVVTLLVYV-RIYVFLRKR---RKKITFRQTSGE---VQQGSAQPSAETCLQEETRKVRRDLSPIRINVVNESTEKVVRPRLLSGCLRRKRPRTVPVENSL-----LPPMDL---------QNYCSISQASFARTEQEPNREEEEGR---EEDQVTVRSCEVKEISNG-RTHTTLRPAPRVTTRASQARYRSIHSREKKATQMLAIVLGVFLICWLPFFVTHILNTHCRSCY-IPPELYSAFTWLGYVNSALNPVIYTTFNIEFRRAFIKILTC 471
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004593.1 (pep scaffold:Pmarinus_7.0:GL476854:168999:207459:1 gene:ENSPMAG00000004184.1 transcript:ENSPMAT00000004593.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 120.939 bits (302), Expect = 5.447e-30 Identity = 77/207 (37.20%), Postives = 116/207 (56.04%), Query Frame = 3
Query: 237 WPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVY-FIIISTVITFVLPLCIMIVTYILTV 854
WP L L++ + T+ GN LV ++V++EK+LQ N+FL+SLA++DLL L VMP+S N++ N + +P +C W LDV F++ +I+HLC+ISLDRY + P+++ RS LKI+ W I IA P+ + L+ QQ G N+ FII +V++F LPL IM+V Y+LT+
Sbjct: 6 WPALLFLLVVVLTVGGNLLVILAVWLEKKLQTATNYFLMSLAVADLLVGLTVMPISVINILYNMRW-PLPCEMCPVWVFLDVLFSTASIMHLCAISLDRYIAIKRPIQHSRFNSRSKTLLKITAVWAISIGIASPIPVLGLQ-----------------------DQQHVFVNGACILNIQNFIIYGSVVSFFLPLLIMVVIYVLTI 188 HSP 2 Score: 67.3958 bits (163), Expect = 3.178e-12 Identity = 35/109 (32.11%), Postives = 62/109 (56.88%), Query Frame = 3
Query: 1320 KQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIK--CQTMT-GPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRKAFSAN 1637
++++ + R+ A+++ ++A +VLGI+F LFL+ + PFFV + C + C L+ W+GY +S +NP+VY +FN T+R F R + C + R S+
Sbjct: 262 RRTQAAHSRSAQALSNERRASKVLGIVFTLFLVMWCPFFVTNVTSALCPESLCSVEAMAKLMDIFVWVGYVSSGVNPLVYTLFNQTYRQAFRRYVACDFRRARHRSSSK 370
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Match: HTR1F (5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292]) HSP 1 Score: 119.013 bits (297), Expect = 4.646e-29 Identity = 109/439 (24.83%), Postives = 185/439 (42.14%), Query Frame = 3
Query: 285 NALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMS--PTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLM 1595
NALV ++ ++L+ N+ + SLA++DLL A LVMPV+A +V ++ +C W SLDV + +I+HLC+I+LDR++ + + +Y + R L I+ +WL+ CI SVP W + + +V + I ST F +PL +++ Y + +A + LY + S + L+ SA++ VS + F P F +S + S Q LA ++S +S + K S P R +S R + R Q R S R ++A + LG++ G F++C+LPFF+ L+ C C ++ + W+GY S++NP++Y +FN F++ F +L+
Sbjct: 65 NALVIAAISATRKLRQPANYLIGSLAVADLLVAALVMPVAAAYVVTGE--WALGGALCDLWLSLDVTCCTASILHLCAIALDRFWAITDAAEYAHKRTPGRAALMIAASWLLAACI--------------------SVPPLFWRRRDPAKPRCIIEH----DHVLYTIYSTFGAFYVPLALLLALYC--------RIFRAAKRLYEKRESKQREKLSV---------------SAESAVSLEQPSQSQHQQQQQQPAGKLFRLP---QPFCMSETS-------------------SSDQTLAQAERSGQHQQSVSAVARRSKRSLRPPRSVRFMSARLD---QRRPCLQERISGSRE-------RRAAKTLGLILGAFVVCWLPFFIKELVVNLCKSC-AVSPEVADLLTWLGYMNSLINPLIYTMFNEDFKSAFRKLV 421
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006953.1 (pep scaffold:Pmarinus_7.0:GL477632:7596:14007:1 gene:ENSPMAG00000006283.1 transcript:ENSPMAT00000006953.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 108.997 bits (271), Expect = 6.735e-26 Identity = 66/200 (33.00%), Postives = 110/200 (55.00%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQ 872
TI GN LV ++V +EK+LQ N+FL+SLA++D+L +LVMP+S N++ + +P +C W LDV F++ +I+HLC+ISLDRY + P+++ R+ LKI W+I I+ P+ + L+ + ++ + C + FII ++ +F LPL IM+ +Y+ T ++RQ
Sbjct: 38 TIAGNVLVILAVSLEKKLQTATNYFLMSLAVADMLVGILVMPISLLNILYGFKW-PLPLSLCPVWIYLDVLFSTASIMHLCAISLDRYIAIKKPIEHSRFNSRTKALLKILAVWVISVGISMPVPVLGLQ-------------DLAYVYTD---------GSCQMNISDFIIYGSLSSFFLPLIIMVASYVSTT-RVLRQ 213 HSP 2 Score: 65.4698 bits (158), Expect = 1.469e-11 Identity = 35/92 (38.04%), Postives = 55/92 (59.78%), Query Frame = 3
Query: 1335 SAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIK--C-QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
S KRT+ A+ + ++A +VLGI+F LF+ + PFF+ +L C C + L+ W+GY +S +NP+VY +FN T+R F R + C
Sbjct: 301 SQKRTMQAITNEQRASKVLGIVFLLFVGMWCPFFITNVLSALCPADACNRHAMAALLDVFVWVGYVSSGVNPLVYTLFNRTYRQAFARYIAC 392
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009127.1 (pep scaffold:Pmarinus_7.0:GL478629:43196:44446:-1 gene:ENSPMAG00000008256.1 transcript:ENSPMAT00000009127.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 98.2117 bits (243), Expect = 2.711e-22 Identity = 64/199 (32.16%), Postives = 107/199 (53.77%), Query Frame = 3
Query: 246 LGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY 842
L L + LC I+GN+ V ++ +E+ LQN N+ + SLA++DLL ++LV+P++A V + ++ + +C + +LDV +++I+HLC I+LDRY+ + NP+ Y N R + IS+ WL+ F I+ P P GW + E + ++ K H + I ST F +PL +M+V Y
Sbjct: 41 LCLTALILCAIFGNSCVIAAIALERTLQNVANYLIGSLAVTDLLVSILVLPMAALYQVLDR--WTLGQVVCDIFIALDVLCCTSSILHLCVIALDRYWAITNPIDYVNKRTPRRAVIMISLTWLVGFSISIP-------------------PMLGWRTPEDRADP-NACKISQDHG--YTIYSTFGAFYIPLILMLVLY 215 HSP 2 Score: 47.3654 bits (111), Expect = 6.756e-6 Identity = 22/54 (40.74%), Postives = 34/54 (62.96%), Query Frame = 3
Query: 1446 LLDFFC-IKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
L+ FC +C G + + W+GYS S+LNPI+Y FN F+N F ++++CK
Sbjct: 332 LISPFCGERCHLPPG-VFAVINWLGYSNSLLNPIIYAYFNKDFQNAFKKIIKCK 384
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Match: CHRM3 (cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952]) HSP 1 Score: 94.7449 bits (234), Expect = 1.164e-20 Identity = 113/503 (22.47%), Postives = 205/503 (40.76%), Query Frame = 3
Query: 258 IIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITD--------------DSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKR------------GSFKISHKNEFTIHLNVPTTDMR-------------RSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRK--NLSNSFRIHKQSRNSAKR-TLAAMN------------SGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
++ L TI GN LV VS + K+L N++L+SLA++DL+ + M + M+ + ++ C W +LD ++ ++++L IS DR+F + PL Y R L I +AW++ F + P +F ++ G R P+ + + +S+ + ++ + + F LP+ IM Y W I ++ ++L + S + D +Q+++ S + + D+ S SS D+P K G H ++ T L D R RSY+ S + SL + S + + + + + R+ S+S RI + ++AKR T AA+ KKA + L + F++ + P+ ++ L+ FC +C + L + W+ Y S +NP+ Y + N FR TF +L+ C+
Sbjct: 69 VMSLATIVGNVLVLVSFKVNKQLHTVNNYYLLSLAVADLIIGIFSMNLFTCYMIMGH--WALGSLACDLWLALDYVASNASVMNLLVISFDRFFSITRPLTYRAKRTPHRAALLIGLAWVVSFVLWAPAILF---WQYIVG-ERTVPPDECRI--QFLSEPIITF------------CTAIAAFYLPVTIMATIY----WRIFKEIQNRARDLAMLQGSVSEGREELEQEEDMVELGDEKEEEEEESTQAVDTPQASGERRRVGNNSSKDNGATSASSHYSEKDDAPKKHRAIYSMVMVLPSGRCSAMHASKVTGRLTAQNVDTRDPMPSHETRIRAVRSYNCSDRSGQTDGASPSL--RQTASERSPAESDASDHSSTSDTREVCAASSSTRISMRDLSTAKRFTSAALKVNVTARKRMSLIKEKKAARTLSAILLAFIITWTPYNIMVLMSTFCPEC--VPPVLWNIGYWLCYVNSTVNPVCYALCNRIFRKTFRQLLLCQ 543
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Match: EDO47359 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMJ9]) HSP 1 Score: 87.8113 bits (216), Expect = 1.473e-18 Identity = 70/270 (25.93%), Postives = 118/270 (43.70%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTS-VPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQ-------NLYP----------NKSSTKSRPLTQIKITDDSQSINETTNSADNDVSY 1007
++I+ L TI GN LVC SVF +RL++ N+ +VSLA+SDLL L +P ++ N+ S + R C W +D+ + ++++L IS DR + PL+Y + I + W+ + +C F W TI+ +Y CG +I + + F PL I+I+ Y + + IR Q ++ N+ P ++S S P+ ++K T S S + N A+ +
Sbjct: 30 IVIVMLLTIMGNLLVCYSVFYYRRLRSPTNYLVVSLAVSDLLVGTLSLPFRLAQLLNEENWPSHLGREGCQFWIWVDMLCSGASMVNLAGISFDRLLAIKQPLRYREKMTSKRALILILVVWI--YAASCAFLSFV-----------------EWEGESTIA----AYPQCGIRARVYITLMALAAFFCPLLIVIICYGMVLQVAIRHALQVQKEKEQIALNVSPEPNSNNHEESGETSLASPPVIRLK-TSRSSSHRKDINFANGHAKH 275 HSP 2 Score: 52.7582 bits (125), Expect = 2.846e-7 Identity = 38/123 (30.89%), Postives = 60/123 (48.78%), Query Frame = 3
Query: 1317 HKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFC-IKC--QTMTGPLVSKTEWIGY------SASMLNPIVYHIFNPTFRNTFNRL---MRCKCYKVRKAFSANTKSY 1649
H + RN A T M KA + L ++ G+F+LC+ PFFVI++ +C +C + P V + I + S S NPI+Y FN FR F ++ M K Y+ + + + +Y
Sbjct: 272 HAKHRNPASSTFHIMKQ-IKATKTLAVVVGVFILCWFPFFVIFVTFQYCDTECFGEERIPPAVKRVLLIIFVYVLPVSNSAANPIIYSCFNQEFRVAFLKIFYKMVGKRYRQKYDYYSTPTAY 393
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Match: EDO35213 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM59]) HSP 1 Score: 77.0258 bits (188), Expect = 1.683e-15 Identity = 37/108 (34.26%), Postives = 68/108 (62.96%), Query Frame = 3
Query: 246 LGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHN 569
+ L+ + + + GN +VC++ + LQ+ F++SLA++D+L A + MP+ + +++FT +P + AW LDV F++ +I++LC+IS+DR F + PL YH
Sbjct: 25 VALIAVIMLALAGNTVVCIAFYRSSNLQSLTVLFILSLAVTDILVASISMPIWLYFQFSHSSFTCLP-DLFTAWKCLDVLFSTASIMNLCAISIDRQFAITKPLHYHT 131
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Match: EDO32939 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STN0]) HSP 1 Score: 75.8702 bits (185), Expect = 6.097e-15 Identity = 56/197 (28.43%), Postives = 87/197 (44.16%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTY 842
L +I + T+ GNA VC++VF+ L N+ + SLA+SDL+ AL +P V N ++ + C W D+F +I++L ISLDR+ PL Y R+ + WL F +A S+ W S E + + GC + YF + + F LPL ++I+ Y
Sbjct: 27 LSVIFVITLLGNATVCLTVFLTSSLHAFTNYIVASLAVSDLMVALFSLPFRIHQTVHNTHW-CLGASACAFWIWADMFCCCASIMNLALISLDRFLATKYPLNYQELINRAGKIAMVVTVWLYSFVVA-------------------SLSLRNWTSPE--GPLVKTINGCFKPDPYFYTFAAALGFFLPLIVIILAY 201
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Match: EDO49367 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG65]) HSP 1 Score: 72.7886 bits (177), Expect = 4.544e-14 Identity = 49/205 (23.90%), Postives = 94/205 (45.85%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQAR 887
T+ GN+LVC+++ ++ RL+N N+F+ SLA++DLL L+ +P + +V+ + C W D+ + +I +L IS+DRY + P +YH L + W+ +A + + +P G Q C N F ++ ++ F+LPL I+++ Y++ ++Q + +
Sbjct: 10 TVAGNSLVCLAICLDHRLRNSTNWFIASLAVADLLYGLIGLP---FRIVQTSGTRVFTLNECFLWIWADMVCAAASIANLAVISVDRYLKITKPFQYHIRMTHKRALLAVVAVWIYSAILA----------------SLSIMPWPGAKGVHLFEQ------SCTNLNQVFYTVANIVAFILPLLILVLNYVMVYVEALKQFRKMK 189
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Match: EDO28603 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T607]) HSP 1 Score: 71.633 bits (174), Expect = 1.671e-13 Identity = 58/232 (25.00%), Postives = 110/232 (47.41%), Query Frame = 3
Query: 252 LLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRL-DHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTV------WSIIRQTNQARQNL-YPNKSSTKS 923
+++I ++GN LVCV+++ +RL++ N+ + SLA+SDLL A L MP ++ + + + +C W +D + +I +L I++DRY VL+ P Y + + I WL F IA +L L + + + N+ S+ C + Y+ + ++F LPL ++I+ Y + ++R+ N ++ +L Y ++S S
Sbjct: 26 VVVILFLDLFGNLLVCVAIYRYRRLRSVTNYLIGSLAVSDLLVACLSMPFRIYHTLHLMCW-DLGLSVCKFWIFVDALCSGASICNLSLIAIDRYLVLSCPFSYREKMRKPRGFIAILAVWLYAFVIA------SLSLTEPWSPDGFNA-----------------SFPACAKMDKYYYAFAITMSFFLPLVVLIIAYSMVFKVARKQACLVRRANDSQGHLEYRTETSVVS 233
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Match: drd3 (dopamine receptor D3 [Source:NCBI gene;Acc:101163209]) HSP 1 Score: 147.902 bits (372), Expect = 4.192e-38 Identity = 136/476 (28.57%), Postives = 218/476 (45.80%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRI-RSSLPLKISIAWLIPFCIACP-LFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYI-LTVWSIIRQT----NQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRR----SYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSN-----SFRIHKQSRNSAK-RTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
+R + L L+I L ++GN LVC++V E+ LQ N+ +VSLA++DLL A LVMP + + V + R C + +LDV + +I++LC+IS+DRY + P+ Y+ T R + I+ W++ F ++CP LF F D M C N F+I S+V++F LP + ++ YI + V+ +R+ QAR + P + Q E T A D+S I V S +S ++ +N +P DM+ S+ + +++ D S +N ++ P R ++ K LSN S R S+N+ + R++ A KKA Q+L I+ G+FL+C+LPFFV ++L+ C CQ + L W+GY S LNP++Y FN FR F +++ C
Sbjct: 35 ERNYYAMLYSLLI-LAIVFGNVLVCLAVLRERSLQTTTNYLVVSLAVADLLVASLVMPWAVYLEVVGGAWL-FNRLYCNIFVTLDVMMCTASILNLCAISIDRYTAVVMPVLYNTTHCSRKRVFAMIATVWVLAFAVSCPLLFGFNTTDDPMV---------------------------CSISNPDFVIYSSVVSFYLPFIVTLLVYIRIYVFLRMRRKRIAFGQARGKVQPGSTHPSVETCLQ-----------EETPKAKQDLSPIRIKVQSVESSGTSKPSLLSGCLWRKRPKTGPAQNS-----GLPPVDMQNYCSISHASCGRTEFDLEQGQVEQDA---SDSNQLELPPIRMNCEV---KELSNGRTHTSLRPISHSQNNPRFRSMHARE--KKATQMLAIVLGVFLICWLPFFVTHILNTHCRTCQ-IPPALYGAFTWLGYVNSALNPVIYTTFNIEFRRAFIKILSC 456
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Match: ENSORLT00000042787.1 (alpha-2B adrenergic receptor-like [Source:NCBI gene;Acc:101155866]) HSP 1 Score: 140.198 bits (352), Expect = 2.256e-35 Identity = 127/469 (27.08%), Postives = 203/469 (43.28%), Query Frame = 3
Query: 273 TIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVS-AWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHN-VYFIIISTVITFVLPLCIMIVTYILTVWSIIRQ-----TNQARQNLYPNKSSTKSRPLTQIK-ITDDSQSINETTNSADNDVSYSMIGVD-----DKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFK-----------MSPT-RYGNQL---SIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLM 1595
TI GN LV ++V + + L+ N FLVSLA +D+L AL+V+P S A+ ++ F+S+ C +LDV F + +I+HLC+I+LDRY ++ P+ Y TR R + I + WLI ++ P ++ D + G C P + ++I+ ST+ +F P IMI+ YI ++ I ++ + R++ Y + T++K + ++SQ A ++S + + D DK K F+ + D+ ++ + A+ SS D QS + SPT RY N + S K L K R A +N K+ VL ++ G+F++C+ PFF Y L C + + PL W GY S LNPI+Y IFN FR F R++
Sbjct: 41 TIVGNILVIIAVLMSRSLRGPQNLFLVSLAAADILVALIVVPFSMAYELLGCWVFSSI---WCEIHKALDVLFCTASIVHLCAIALDRYLSISRPVSYGTTRSRRRIKSAIVMVWLIAAVVSFPPLLYLDTKDKVKGK-------------------------CEPDDKPWYILYSTIGSFFAPCVIMILVYI-RIYQIAKRHMHCPPGEKRRSFYGAATDD-----TEMKSLPEESQKDVGQRAPAAPELSLTTVHTDCAQWNDK----------------KPAESPTEGPPLFSTAVPNAARDLPKA-----EGEDAVHTSSSESDTELQSIEEGDRAGGGGSPKAQVQSPTCRYKNTIKTSSGTKLLPED--TAKTQETPISRHKAMINREKRFTLVLAVVMGVFVVCWFPFFFSYSLKAVCPEKYQVPDPLFRFFFWSGYCNSCLNPIIYTIFNRDFRTAFKRIL 452
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Match: adra2a (adrenoceptor alpha 2A [Source:NCBI gene;Acc:266750]) HSP 1 Score: 137.502 bits (345), Expect = 8.667e-35 Identity = 121/449 (26.95%), Postives = 187/449 (41.65%), Query Frame = 3
Query: 276 IWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRK 1622
++GN LV ++VF + L+ N FLVSLA +D+L A LVMP S N + F + C + +LDV F + +I HLC+ISLDRY+ + ++Y+ R + I I W+I I+ P I M N + P +++ K +++I S + +F LP IM++ Y+ I Q + R P K L+ Q N D + G D V+RG+ +E + +N + S D +I K+S+ ++S + G+ R+ S A R N K+ VL ++ G+F++C+ PFF Y+L C C T L + W GY S LNPI+Y IFN FR F +++ C + RK
Sbjct: 31 VFGNVLVVIAVFTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMG--FWYFGKVWCEIYLALDVLFCTASIAHLCAISLDRYWSITQAIEYNLKRTPRRIKSIIVIVWVIAAVISFPPLI------TMEKENGSESPVC----------KINDEK-------WYVISSCIGSFFLPCIIMVLVYVR-----IYQIAKKRTRAPPGDRQQKG--LSGPGAAAAGQRENGVGEPDDGLCHEKLNGEQD----------VELKEGVERGA------DEAKVEVNGGDMEESSSSDHKADHPCSIPKKSA---------KGKTRLSQVKPGDADPQRRAQS----------AKASRWKGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYMLKTLCSSCYVPTA-LFNFFFWFGYCNSALNPIIYTIFNHDFRRAFKKIL---CRERRK 408
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Match: htr2b (5-hydroxytryptamine receptor 2B [Source:NCBI gene;Acc:101162203]) HSP 1 Score: 137.887 bits (346), Expect = 1.929e-34 Identity = 84/238 (35.29%), Postives = 138/238 (57.98%), Query Frame = 3
Query: 228 RYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQI 941
+ +W L ++++ + TI GN LV ++V +E++LQN N+FL+SLA++DLL LLVMP++ ++ N+ + +P +C W LDV F++ +I+HLC+ISLDRY + P+++ + R+ +KI++ WLI CIA P+ I L H + N + SN T + D+++ FII ++ F +PL IM+V Y+LTV + R+ +Y KS R +QI
Sbjct: 23 QLKWAALLIIMVIIPTIGGNILVILAVSLERKLQNATNYFLMSLAVADLLVGLLVMPIALVTVLYNSGW-PLPDFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQYKSRAKAIVKIALVWLISICIAIPIPIKGLTNYHPSNN-------ITFNSNHTCLLKTDTFRD-------FIIFGSLAAFFIPLMIMMVIYLLTVQVL-------RKKVYLLKSKVTQRFNSQI 238 HSP 2 Score: 69.707 bits (169), Expect = 3.760e-12 Identity = 31/89 (34.83%), Postives = 55/89 (61.80%), Query Frame = 3
Query: 1338 AKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQ-TMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRC 1601
K+++ +++ ++A +VLGI+F LF++ + PFF+ + C C ++ L+ W+GY +S +NP+VY +FN TFR F R + C
Sbjct: 293 GKKSMQTLSNEQRASKVLGIVFLLFVVMWCPFFITNITSALCTSCSASIVSRLMEIFVWVGYVSSGINPLVYTLFNKTFREAFTRYITC 381
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Match: ADRA2C (adrenoceptor alpha 2C [Source:HGNC Symbol;Acc:HGNC:283]) HSP 1 Score: 130.954 bits (328), Expect = 2.438e-32 Identity = 132/472 (27.97%), Postives = 203/472 (43.01%), Query Frame = 3
Query: 267 LCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNN-NFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKIS---HKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQ--SRNSAKR---------TLAAMNSGKKAVQ--------VLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYK 1613
L T+ GN LV ++V + L+ N FLVSLA +D+L A LVMP S N + F V GI LA LDV F +++I+HLC+ISLDRY+ + ++Y+ R + I I WL+ I+ P + R N+ +S P+ L++ET ++I+ S++ +F P IMI+ YI ++ + + T++R +++ K D + +T N G K+S H H + P T +R+ P Q+ +D S + +P R +Q + RK +SF H SR S K + + KK Q VL ++ G+F++C+ PFF Y L C + PL WIGY S LNP +Y IFN FR+ F +++ CK +K
Sbjct: 47 LFTVVGNILVVIAVLTSRALKAPQNLFLVSLATADILVATLVMPFSLANELMGYWYFGKVWCGIYLA---LDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKCTILIVWLVSAFISSPPLVSIDR-----NNDISSQPQCE-LNDET----------------WYILSSSIASFFAPCLIMILVYI-RIYQVAK---------------TRTRSMSEKKPKPD--GVTQTEN----------------------------------GLSKVSSPLHGEAENGHCHCPPTPSQRTVTTGP--------QTQEVDVEESSSSEGKGHNPQRQDSQRA-RKARKSSFSKHSAHISRVSNKSMDLFASRRKRRRSSFARKKVSQAREKRFTFVLAVVMGVFVMCWFPFFFSYSLYGVCRDSCRIPDPLFKFFFWIGYCNSSLNPAIYTIFNRDFRHAFQKIL-CKAWK 431
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Match: SMESG000032679.1 (SMESG000032679.1) HSP 1 Score: 952.584 bits (2461), Expect = 0.000e+0 Identity = 476/478 (99.58%), Postives = 477/478 (99.79%), Query Frame = 3
Query: 219 AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRKAFSANTKSYV 1652
AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCSHSSLSLNSFDSPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSL DK+FQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRKAFSANTKSYV
Sbjct: 26 AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCSHSSLSLNSFDSPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLTDKNFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKVRKAFSANTKSYV 503
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Match: SMESG000032682.1 (SMESG000032682.1) HSP 1 Score: 936.021 bits (2418), Expect = 0.000e+0 Identity = 460/462 (99.57%), Postives = 461/462 (99.78%), Query Frame = 3
Query: 219 AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 1604
AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCSHSSLSLNSFDSPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSL DK+FQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK
Sbjct: 26 AFDRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCSHSSLSLNSFDSPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLTDKNFQSFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCK 487
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Match: SMESG000065390.1 (SMESG000065390.1) HSP 1 Score: 374.015 bits (959), Expect = 5.458e-123 Identity = 215/488 (44.06%), Postives = 301/488 (61.68%), Query Frame = 3
Query: 234 QWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSSTKSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKISHKNEFTIHLNVPTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQSFNNSFKMSPTRYGNQLSI--RKNLSNSFRIHKQSRNSAKR-------------------------TLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKCQTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKV 1616
+W FL LL+IP+ TI+GN LV VSV++EKRLQNRFN+FLVSLA+SD LCA+LVMPVS MV + P +CLAWYSLDVFFT+TTIIHLC+IS+DRY LNNPL++H T+ + SL +KISI+WLIPF IACPLF+ +L++ ET++Q+ S+KGCGP+N FI+ + ++TF+LPL IM+++YILTV +I +QT + + KSR +Q +I S ++ S++ V+ K C + SLN + S S ++ + + N PTT + ++N+ K++ F+ +R Q+SI RK N+ R+H+ S +++R +L + +KAVQVLGI+FGLF+ CY+PFFVIYL DFFC+ C+++T ++S +EWIGYSASM+NP+VYHIFNPTFR TFNRL+RC+CYKV
Sbjct: 28 KWAFLFLLLIPIITIFGNILVGVSVYLEKRLQNRFNYFLVSLAVSDFLCAILVMPVSTVKMVHVDLTNGWPHQLCLAWYSLDVFFTATTIIHLCTISIDRYVALNNPLRFHQTKRKYSLFIKISISWLIPFGIACPLFLSSLKI-------------------ETMNQEESSFKGCGPNNAIFIMTAVIVTFILPLLIMMISYILTVKTIRKQTKNL--DSFSTNGHRKSR-FSQSEIYKKSM--------PSTSLTTSILNVNSKVCDDLNHSLNQEKLSLLSISTDFSRRSLMSCN-NFPTTPSK------IQENIDGDKETYF----------DFRSKFSRLSRQMSIPFRK---NTLRLHRNSSVNSERLRLCANVLLNSRLSVNSRRIATSDLSLRYIQKSRKAVQVLGIVFGLFVCCYMPFFVIYLTDFFCVSCKSITSWMISYSEWIGYSASMMNPVVYHIFNPTFRRTFNRLIRCRCYKV 465
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Match: SMESG000000740.1 (SMESG000000740.1) HSP 1 Score: 342.813 bits (878), Expect = 1.050e-110 Identity = 190/502 (37.85%), Postives = 280/502 (55.78%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSST------KSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKI------SHKNEFTIHLNV---------PTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQ---------------SFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKV 1616
RY W ++GL IIP+ ++WGN+LVC+SV++E L+ RFN+FLVSLA+SD LCA+LVMP+SAW M+ N ++ CL WYSLDVFFT++TIIHLC+IS+DRY L NPLK H + SL +++ AW+IPF IACPLF+FAL LD +++ S+KGCGP N YFI+I+T++TF +PL IM VTY+LTV + Q +A NLY N ++ S L + T ++ ++E + N+ S +M + + F F++ + +N F + ++ P+ + P++ ++ ++Q + ++ S SFKMS K ++ + + ++ L +N +KAVQ LGILF LF++CYLPFFV YL+DFF C + +++ EW+GYS SM NPIVYH FNP FR+T+ RLM+C+CY+V
Sbjct: 5 SRYNWAYVGLFIIPMLSMWGNSLVCISVWVEVGLRKRFNYFLVSLAMSDFLCAILVMPISAWKMIDNYYLETINHQWCLIWYSLDVFFTASTIIHLCTISIDRYNALKNPLKIHGQKRYRSLVVQLVCAWIIPFSIACPLFLFALELDK--------------------TREHSSFKGCGPQNAYFILIATIVTFFIPLIIMTVTYVLTVKILYVQRKEAEANLYSNAVASLVFKPKLSSSLAKFTRTPSTKVMSEKKLNGKNENSSAMHRRSISTSCLVNSLDSEFKETENHNHFEMTPLLAKTTRNNFVENTSMNLCGSDNLKPSLQEDQYKQTLPQRQVSFREQQKTKNHYWKSNTVCTVLENPLALLSHQRSFKMS----------NKTKTDEYSAFYTKKKETEKQLKQINRSRKAVQTLGILFLLFVICYLPFFVAYLVDFFFKICSVSSTAEKMLTFLEWMGYSGSMFNPIVYHFFNPIFRHTYQRLMKCQCYRV 476
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Match: SMESG000000740.1 (SMESG000000740.1) HSP 1 Score: 342.428 bits (877), Expect = 2.025e-110 Identity = 190/502 (37.85%), Postives = 280/502 (55.78%), Query Frame = 3
Query: 225 DRYQWPFLGLLIIPLCTIWGNALVCVSVFIEKRLQNRFNFFLVSLAISDLLCALLVMPVSAWNMVRNNNFTSVPRGICLAWYSLDVFFTSTTIIHLCSISLDRYFVLNNPLKYHNTRIRSSLPLKISIAWLIPFCIACPLFIFALRLDHMAGNNRNSVPESGWLSNETISQQLDSYKGCGPHNVYFIIISTVITFVLPLCIMIVTYILTVWSIIRQTNQARQNLYPNKSST------KSRPLTQIKITDDSQSINETTNSADNDVSYSMIGVDDKYCXXXXXXXXXXXXPVKRGSFKI------SHKNEFTIHLNV---------PTTDMRRSYDFSPKQNLAIKKQSSLIDKSFQ---------------SFNNSFKMSPTRYGNQLSIRKNLSNSFRIHKQSRNSAKRTLAAMNSGKKAVQVLGILFGLFLLCYLPFFVIYLLDFFCIKC--QTMTGPLVSKTEWIGYSASMLNPIVYHIFNPTFRNTFNRLMRCKCYKV 1616
RY W ++GL IIP+ ++WGN+LVC+SV++E L+ RFN+FLVSLA+SD LCA+LVMP+SAW M+ N ++ CL WYSLDVFFT++TIIHLC+IS+DRY L NPLK H + SL +++ AW+IPF IACPLF+FAL LD +++ S+KGCGP N YFI+I+T++TF +PL IM VTY+LTV + Q +A NLY N ++ S L + T ++ ++E + N+ S +M + + F F++ + +N F + ++ P+ + P++ ++ ++Q + ++ S SFKMS K ++ + + ++ L +N +KAVQ LGILF LF++CYLPFFV YL+DFF C + +++ EW+GYS SM NPIVYH FNP FR+T+ RLM+C+CY+V
Sbjct: 15 SRYNWAYVGLFIIPMLSMWGNSLVCISVWVEVGLRKRFNYFLVSLAMSDFLCAILVMPISAWKMIDNYYLETINHQWCLIWYSLDVFFTASTIIHLCTISIDRYNALKNPLKIHGQKRYRSLVVQLVCAWIIPFSIACPLFLFALELDK--------------------TREHSSFKGCGPQNAYFILIATIVTFFIPLIIMTVTYVLTVKILYVQRKEAEANLYSNAVASLVFKPKLSSSLAKFTRTPSTKVMSEKKLNGKNENSSAMHRRSISTSCLVNSLDSEFKETENHNHFEMTPLLAKTTRNNFVENTSMNLCGSDNLKPSLQEDQYKQTLPQRQVSFREQQKTKNHYWKSNTVCTVLENPLALLSHQRSFKMS----------NKTKTDEYSAFYTKKKETEKQLKQINRSRKAVQTLGILFLLFVICYLPFFVAYLVDFFFKICSVSSTAEKMLTFLEWMGYSGSMFNPIVYHFFNPIFRHTYQRLMKCQCYRV 486 The following BLAST results are available for this feature:
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of 5-hydroxytryptamine receptor 2C vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021550 ID=SMED30021550|Name=5-hydroxytryptamine receptor 2C|organism=Schmidtea mediterranea sexual|type=transcript|length=1978bpback to top protein sequence of SMED30021550-orf-1 >SMED30021550-orf-1 ID=SMED30021550-orf-1|Name=SMED30021550-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=504bp MASSSADLNNRSSSGSGGGVGGGSSAFDRYQWPFLGLLIIPLCTIWGNALback to top protein sequence of SMED30021550-orf-2 >SMED30021550-orf-2 ID=SMED30021550-orf-2|Name=SMED30021550-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=188bp MNSGQAMQNGINHAMLIFRGNEDLMRVLWYFKGLFSTKYLSNEIEQRWMIback to top Aliases
The feature '5-hydroxytryptamine receptor 2C' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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