S-adenosylmethionine synthase

Overview


Name	S-adenosylmethionine synthase
Smed ID	SMED30021445
Length (bp)	1392

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of S-adenosylmethionine synthase (SMED30021445) t-SNE clustered cells

Violin plots show distribution of expression levels for S-adenosylmethionine synthase (SMED30021445) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of S-adenosylmethionine synthase (SMED30021445) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for S-adenosylmethionine synthase (SMED30021445) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30021445

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
gut	SMED30021445	SMESG000053202.1	EG413862	ncbi_smed_ests	PMID:23318641 Chen et al., 2013
intestinal phagocyte	SMED30021445	SMESG000067492.1	Contig5554	GPL15192	PMID:23079596 Forsthoefel et al., 2012
intestinal phagocyte	SMED30021445	SMESG000053202.1	Contig5554	GPL15192	PMID:23079596 Forsthoefel et al., 2012
pigment cell	SMED30021445	SMESG000053202.1	SmedASXL_006595	SmedAsxl_ww_GCZZ01	PMID:29158443 He et al., 2017
gut	SMED30021445	SMESG000053202.1 SMESG000053199.1	dd_Smed_v4_907_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30021445	SMESG000053202.1 SMESG000053199.1	dd_Smed_v4_907_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30021445	SMESG000053202.1 SMESG000053199.1	dd_Smed_v4_907_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30021445	SMESG000053202.1 SMESG000053199.1	dd_Smed_v4_907_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30021445	SMESG000053202.1 SMESG000053199.1	dd_Smed_v4_907_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30021445	SMESG000067492.1	Contig5554	GPL15192	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30021445	SMESG000053202.1 SMESG000053199.1	Contig39602	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30021445	SMESG000053202.1 SMESG000053199.1	Contig39602	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30021445	SMESG000053202.1	Contig5554	GPL15192	PMID:29674431 Fincher et al., 2018
gut	SMED30021445	SMESG000053202.1	EG413862	ncbi_smed_ests	PMID:21566185 Wagner et al., 2011
gastrodermal cell	SMED30021445	SMESG000053202.1	EG413862	ncbi_smed_ests	PMID:21566185 Wagner et al., 2011

Note: Hover over icons to view figure legend

Homology

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BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT2A (methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

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BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT1A (methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 273/385 (70.91%), Postives = 331/385 (85.97%), Query Frame = 1

Query:  154 HNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +E  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT++LAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I + ++R+ L E V++ V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT    + +LL++++ NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE P+ L +
Sbjct:   11 HSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF 395

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BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT2A (methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904])

HSP 1 Score: 429.483 bits (1103), Expect = 1.431e-149
Identity = 215/297 (72.39%), Postives = 251/297 (84.51%), Query Frame = 1

Query:  313 MILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHI 1203
            MIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I
Sbjct:    1 MILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI 297

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BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT1A (methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903])

HSP 1 Score: 222.246 bits (565), Expect = 1.154e-70
Identity = 108/186 (58.06%), Postives = 130/186 (69.89%), Query Frame = 1

Query:  190 ESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQ 747
            ESVGEGHPDKICDQ+SDAVLDAHL QDP AKVAC                                         GFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT++LAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS Q
Sbjct:    1 ESVGEGHPDKICDQISDAVLDAHLKQDPNAKVAC-----------------------------------------GFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQ 145

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BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-3 (Probable S-adenosylmethionine synthase 3 [Source:UniProtKB/Swiss-Prot;Acc:P50305])

HSP 1 Score: 531.946 bits (1369), Expect = 0.000e+0
Identity = 260/382 (68.06%), Postives = 318/382 (83.25%), Query Frame = 1

Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVK+GLCRR LVQ+SYAIG+A PLS+ V S+GT ++ + +LL+I+NDNFDLRPG I KDLDL++PIY+ TA  GHFG  EF WEQP+ L+
Sbjct:    1 MSQHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFGHNEFPWEQPRHLQ 382

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-4 (Probable S-adenosylmethionine synthase 4 [Source:UniProtKB/Swiss-Prot;Acc:P50306])

HSP 1 Score: 531.561 bits (1368), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 314/380 (82.63%), Query Frame = 1

Query:  166 EETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            +  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +  LL I+NDNFDLRPG I K+LDL+RPIY+ TA  GHFG   F WEQP+ LK
Sbjct:    3 QHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382

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Query:  166 EETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            +  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +  LL I+NDNFDLRPG I K+LDL+RPIY+ TA  GHFG   F WEQP+ LK
Sbjct:    3 QHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-5 (Probable S-adenosylmethionine synthase 5 [Source:UniProtKB/Swiss-Prot;Acc:Q27522])

HSP 1 Score: 524.628 bits (1350), Expect = 0.000e+0
Identity = 258/382 (67.54%), Postives = 315/382 (82.46%), Query Frame = 1

Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++   D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I +  LRK+L+E V+K VIP   +D  T+YHLNP G FV+GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +++LL+I+NDNFDLRPG I K+LDL+R IY+ TA  GHFG  +F WEQ + LK
Sbjct:    1 MSKNKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDIADVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELEWVRPDSKTQVTIEYSSEGGACVPLRVHTVVISTQHSPDISLEDLRKELIEKVIKVVIPGNLIDNDTVYHLNPCGSFVVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEAELLKIVNDNFDLRPGMIIKNLDLKRAIYEPTAENGHFGHNDFPWEQARKLK 382

[Close]

Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++   D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I +  LRK+L+E V+K VIP   +D  T+YHLNP G FV+GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +++LL+I+NDNFDLRPG I K+LDL+R IY+ TA  GHFG  +F WEQ + LK
Sbjct:    1 MSKNKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDIADVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELEWVRPDSKTQVTIEYSSEGGACVPLRVHTVVISTQHSPDISLEDLRKELIEKVIKVVIPGNLIDNDTVYHLNPCGSFVVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEAELLKIVNDNFDLRPGMIIKNLDLKRAIYEPTAENGHFGHNDFPWEQARKLK 382

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089430)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089433)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089432)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089429)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089434)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat2aa (methionine adenosyltransferase II, alpha a [Source:ZFIN;Acc:ZDB-GENE-030131-2049])

HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0
Identity = 282/395 (71.39%), Postives = 332/395 (84.05%), Query Frame = 1

Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN   +E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS+A+V+YQ+V+R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHD+ + ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLC+RVLVQ+SYAIG+A PLS+ +  YGT    + +LLEI+  NFDLRPG I ++LDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHNSLIDEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSHAVVDYQKVVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDDVVCLDEMRDALKEKVVKAVVPNVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCKRVLVQVSYAIGVAHPLSVSIFHYGTSQRSEKELLEIVKKNFDLRPGVIVRELDLKKPIYQRTAAYGHFGRESFPWEVPKKLKY 395

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat1a (methionine adenosyltransferase I, alpha [Source:ZFIN;Acc:ZDB-GENE-030131-6127])

HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0
Identity = 278/387 (71.83%), Postives = 330/387 (85.27%), Query Frame = 1

Query:  145 NSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            N +H+  + +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+++R TIK IG+D+ EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+NI + + ++ L E V+K V+P +YLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG+A PLSI + +YG+    + +LL I+N NFDLRPG I +DL+L+RP YQ TACYGHFGR EF WE  KTLK
Sbjct:    5 NDVHD--DGSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKIVRDTIKHIGYDNSEKGFDYKTCNVLVALEQQSPDIAQGVHVDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDNISLEEQQRILKEKVIKAVVPARYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSKLCRRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLHIVNKNFDLRPGVIVRDLNLKRPFYQNTACYGHFGRSEFPWEMAKTLK 389

[Close]

Query:  145 NSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            N +H+  + +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+++R TIK IG+D+ EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+NI + + ++ L E V+K V+P +YLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG+A PLSI + +YG+    + +LL I+N NFDLRPG I +DL+L+RP YQ TACYGHFGR EF WE  KTLK
Sbjct:    5 NDVHD--DGSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKIVRDTIKHIGYDNSEKGFDYKTCNVLVALEQQSPDIAQGVHVDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDNISLEEQQRILKEKVIKAVVPARYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSKLCRRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLHIVNKNFDLRPGVIVRDLNLKRPFYQNTACYGHFGRSEFPWEMAKTLK 389

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat2al (methionine adenosyltransferase II, alpha-like [Source:ZFIN;Acc:ZDB-GENE-060421-5255])

HSP 1 Score: 522.702 bits (1345), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 310/380 (81.58%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+L+QDP ++VACE  SKTGMIL+ GE+TS A+V+ QRV+R T+K IG+D   KGFDYKTCN+L++++ Q  EI+  V E R  EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  +    P++ PD+KTQVTV Y+   GA  P++VHT+VIS QH  +I +  +R +LME VVK VIP KYLD  TIYHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLS+ V  YGT +  +  LLEI+  NFDLRPG I K+LDL++PIYQKTACYGHFGR  F WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLTQDPDSRVACECVSKTGMILLCGEVTSKAVVDLQRVVRDTVKTIGYDDSSKGFDYKTCNVLVSLQPQVSEISDCVFEGRDSEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNYKMKELSKTGVCPWILPDSKTQVTVEYRDNMGAMEPVRVHTVVISVQHSPDITLEDIRHNLMEKVVKAVIPAKYLDDKTIYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSVSVFHYGTSTRDEDDLLEIVKKNFDLRPGVIVKELDLKKPIYQKTACYGHFGREGFPWEKPKKLIF 390

[Close]

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+L+QDP ++VACE  SKTGMIL+ GE+TS A+V+ QRV+R T+K IG+D   KGFDYKTCN+L++++ Q  EI+  V E R  EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  +    P++ PD+KTQVTV Y+   GA  P++VHT+VIS QH  +I +  +R +LME VVK VIP KYLD  TIYHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLS+ V  YGT +  +  LLEI+  NFDLRPG I K+LDL++PIYQKTACYGHFGR  F WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLTQDPDSRVACECVSKTGMILLCGEVTSKAVVDLQRVVRDTVKTIGYDDSSKGFDYKTCNVLVSLQPQVSEISDCVFEGRDSEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNYKMKELSKTGVCPWILPDSKTQVTVEYRDNMGAMEPVRVHTVVISVQHSPDITLEDIRHNLMEKVVKAVIPAKYLDDKTIYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSVSVFHYGTSTRDEDDLLEIVKKNFDLRPGVIVKELDLKKPIYQKTACYGHFGREGFPWEKPKKLIF 390

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: mat1a (methionine adenosyltransferase I, alpha [Source:NCBI gene;Acc:100127858])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 278/379 (73.35%), Postives = 326/379 (86.02%), Query Frame = 1

Query:  172 TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
             F+FTSESVGEGHPDKICDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A+V+YQ+++R TIK IG+D  EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN  LP+LRPD+KTQVTV Y   NGA IP++VHTIVIS QHDE I ++ +++ L EHV+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC RVLVQ+SYAIG+A PLS+ + +YGT    + +LL+I+N NFDLRPG I +DLDL++P+YQKTACYGHFGR +F WE PK L +
Sbjct:   18 AFMFTSESVGEGHPDKICDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRAVVDYQKIVRDTIKYIGYDDSEKGFDYKTCNVLVALEQQSPDIAQGVHLDRTEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKLAELRRNGVLPWLRPDSKTQVTVKYIQKNGAVIPVRVHTIVISVQHDETISLSDMQEALKEHVIKAVVPAKYLDEKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVHAKLCHRVLVQVSYAIGVAYPLSVSLFTYGTSEKTEKELLDIVNANFDLRPGVIVRDLDLKKPLYQKTACYGHFGREDFPWEVPKELFF 396

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 277/390 (71.03%), Postives = 327/390 (83.85%), Query Frame = 1

Query:  145 NSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+   +E +FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    4 NGFHDDLIDEGSFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 393

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 561.992 bits (1447), Expect = 0.000e+0
Identity = 277/390 (71.03%), Postives = 327/390 (83.85%), Query Frame = 1

Query:  145 NSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+   +E +FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    7 NGFHDDLIDEGSFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 396

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: mat1a (methionine adenosyltransferase I, alpha [Source:NCBI gene;Acc:100127858])

HSP 1 Score: 537.724 bits (1384), Expect = 0.000e+0
Identity = 264/363 (72.73%), Postives = 311/363 (85.67%), Query Frame = 1

Query:  220 ICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            ICDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A+V+YQ+++R TIK IG+D  EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN  LP+LRPD+KTQVTV Y   NGA IP++VHTIVIS QHDE I ++ +++ L EHV+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC RVLVQ+SYAIG+A PLS+ + +YGT    + +LL+I+N NFDLRPG I +DLDL++P+YQKTACYGHFGR +F WE PK L +
Sbjct:    4 ICDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRAVVDYQKIVRDTIKYIGYDDSEKGFDYKTCNVLVALEQQSPDIAQGVHLDRTEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKLAELRRNGVLPWLRPDSKTQVTVKYIQKNGAVIPVRVHTIVISVQHDETISLSDMQEALKEHVIKAVVPAKYLDEKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVHAKLCHRVLVQVSYAIGVAYPLSVSLFTYGTSEKTEKELLDIVNANFDLRPGVIVRDLDLKKPLYQKTACYGHFGREDFPWEVPKELFF 366

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 529.25 bits (1362), Expect = 0.000e+0
Identity = 266/390 (68.21%), Postives = 316/390 (81.03%), Query Frame = 1

Query:  139 NPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            NP++ H      FLF          +KICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    7 NPSANH------FLFK---------NKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 381

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat2a (methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

[Close]

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat1a (methionine adenosyltransferase I, alpha [Source:MGI Symbol;Acc:MGI:88017])

HSP 1 Score: 568.926 bits (1465), Expect = 0.000e+0
Identity = 278/386 (72.02%), Postives = 332/386 (86.01%), Query Frame = 1

Query:  154 HNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +EE  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I +  +++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT +  + +LLE++N NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE PK L +
Sbjct:   11 HSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 396

[Close]

Query:  154 HNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +EE  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I +  +++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT +  + +LLE++N NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE PK L +
Sbjct:   11 HSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 396

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat2a (methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731])

HSP 1 Score: 520.776 bits (1340), Expect = 0.000e+0
Identity = 264/364 (72.53%), Postives = 303/364 (83.24%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDL 1215
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I + L
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRVL 364

[Close]

BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q5R5H1|METK2_PONAB (S-adenosylmethionine synthase isoform type-2 OS=Pongo abelii OX=9601 GN=MAT2A PE=2 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

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BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q3THS6|METK2_MOUSE (S-adenosylmethionine synthase isoform type-2 OS=Mus musculus OX=10090 GN=Mat2a PE=1 SV=2)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

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BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q4R924|METK2_MACFA (S-adenosylmethionine synthase isoform type-2 OS=Macaca fascicularis OX=9541 GN=MAT2A PE=2 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

[Close]

BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|P31153|METK2_HUMAN (S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

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BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|P18298|METK2_RAT (S-adenosylmethionine synthase isoform type-2 OS=Rattus norvegicus OX=10116 GN=Mat2a PE=1 SV=1)

HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0
Identity = 286/395 (72.41%), Postives = 330/395 (83.54%), Query Frame = 1

Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ++DAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIVIS QHDE + ++++R  L E ++K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+ +NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395

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BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A1I8I605 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g3 PE=3 SV=1)

HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0
Identity = 295/380 (77.63%), Postives = 340/380 (89.47%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+MEHVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMEHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLRIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387

[Close]

BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A1I8HKQ4 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g1 PE=3 SV=1)

HSP 1 Score: 608.216 bits (1567), Expect = 0.000e+0
Identity = 295/380 (77.63%), Postives = 340/380 (89.47%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+MEHVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMEHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLHIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387

[Close]

BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267DP28 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g2 PE=3 SV=1)

HSP 1 Score: 607.06 bits (1564), Expect = 0.000e+0
Identity = 294/380 (77.37%), Postives = 340/380 (89.47%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+M+HVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMDHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLRIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387

[Close]

BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267H2L8 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014959g3 PE=3 SV=1)

HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0
Identity = 290/380 (76.32%), Postives = 338/380 (88.95%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QD  AKVACE F+KTGMI++GGEI+S AIV+YQRVIR+TI+ IG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VH  R+D+DIGAGDQGLMFGYATDETEECMPLT+VLAHGLN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHD+NI   +LR D+MEHVVK V P++ LD  T+YHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PL+++++SYGTG+  D +LL I+  NFDLRPG I KDL+LR+PIYQKT+CYGHFG PEF+WE  K LK+
Sbjct:   10 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDANAKVACECFTKTGMIMVGGEISSTAIVDYQRVIRETIRQIGYDDSSKGFDYKTCNVLVALEEQSPDIAQGVHVARADDDIGAGDQGLMFGYATDETEECMPLTIVLAHGLNARLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDDNITQEKLRHDVMEHVVKAVCPKEMLDERTVYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQISYAIGVAKPLAVYLNSYGTGAKSDEELLRIVETNFDLRPGRIVKDLELRKPIYQKTSCYGHFGNPEFSWEMAKELKF 389

[Close]

BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267EMZ1 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014959g2 PE=3 SV=1)

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 289/380 (76.05%), Postives = 338/380 (88.95%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QD  AKVACE F+KTGMI++GGEI+S AIV+YQRVIR+TI+ IG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VH  R+D+DIGAGDQGLMFGYATDETEECMPLT+VLAHGLN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHD+NI   +LR D+MEHVVK V P++ LD  T+YHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PL+++++SYGTG+  D +LL I+  NFDLRPG I KDL+LR+PIYQKT+CYGHFG PEF+WE  K L++
Sbjct:   10 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDANAKVACECFTKTGMIMVGGEISSTAIVDYQRVIRETIRQIGYDDSSKGFDYKTCNVLVALEEQSPDIAQGVHVARADDDIGAGDQGLMFGYATDETEECMPLTIVLAHGLNARLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDDNITQEKLRHDVMEHVVKAVCPKEMLDERTVYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQISYAIGVAKPLAVYLNSYGTGAKSDEELLRIVETNFDLRPGRIVKDLELRKPIYQKTSCYGHFGNPEFSWEMAKELQF 389

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BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2ab (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103044681])

HSP 1 Score: 566.229 bits (1458), Expect = 0.000e+0
Identity = 281/396 (70.96%), Postives = 329/396 (83.08%), Query Frame = 1

Query:  127 KMRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +M    N  HN   +E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R TI+ IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R+ ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN  LP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHDE+I ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DL LR+PIYQ+TA YGHFGR  F+WE PK L+Y
Sbjct:    5 EMNGEMNGFHNALIDEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRATVDYQKVVRDTIRHIGYDDSTKGFDYKTCNVLVALEQQSPDIAQGVHLDRNQEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGVLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDEDICLDEMRDALKEKVVKAVVPCVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAELCRRVLVQVSYAIGVAHPLSISIFHYGTSQKSERELLDIVRKNFDLRPGVIVRDLQLRKPIYQRTAAYGHFGRDSFSWEIPKKLQY 400

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103041217])

HSP 1 Score: 562.762 bits (1449), Expect = 0.000e+0
Identity = 278/387 (71.83%), Postives = 333/387 (86.05%), Query Frame = 1

Query:  151 IHNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +++F+++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+ I + + ++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC+RVLVQ+SYAIG+A PLSI + +YG+    + +LL+I+N NFDLRPG I +DL L+RPIYQ TACYGHFGR EF WE PKTLK+
Sbjct:    4 LNDFHDDGSFMFTSESVGEGHPDKICDQISDAVLDAHLRQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHIDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDLISLEEQQRILKEKVIKAVVPAKYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVMAKLCKRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLQIVNKNFDLRPGVIVRDLKLKRPIYQDTACYGHFGRSEFPWEVPKTLKF 390

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103041217])

HSP 1 Score: 554.673 bits (1428), Expect = 0.000e+0
Identity = 278/398 (69.85%), Postives = 333/398 (83.67%), Query Frame = 1

Query:  151 IHNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHI-----------EKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +++F+++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+ I + + ++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC+RVLVQ+SYAIG+A PLSI + +YG+    + +LL+I+N NFDLRPG I            +DL L+RPIYQ TACYGHFGR EF WE PKTLK+
Sbjct:    4 LNDFHDDGSFMFTSESVGEGHPDKICDQISDAVLDAHLRQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHIDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDLISLEEQQRILKEKVIKAVVPAKYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVMAKLCKRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLQIVNKNFDLRPGVIVRVFQTWAVNNYRDLKLKRPIYQDTACYGHFGRSEFPWEVPKTLKF 401

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BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2aa (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103039813])

HSP 1 Score: 553.903 bits (1426), Expect = 0.000e+0
Identity = 282/395 (71.39%), Postives = 328/395 (83.04%), Query Frame = 1

Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN    E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R  IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHT+V+S QHDE + ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLC+RVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQVNGFHNSIIEEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRACVDYQKVVRDAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTVVVSVQHDEVVCLDEMRDALKEKVVKAVVPSVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCKRVLVQVSYAIGVAHPLSISIFHYGTSQRSEKELLDIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRESFPWEVPKKLKY 395

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2al (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103022635])

HSP 1 Score: 499.204 bits (1284), Expect = 6.113e-176
Identity = 255/381 (66.93%), Postives = 306/381 (80.31%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQ-GDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVG+GH DK+CDQ+SDAVLDA+LSQDP AKVACE  +KTGMIL+ GE+TS A+V+ ++V+R T+KDIG+D   KGFDYKTCN+L+A++ Q  EI   V E R +EDIGAGDQG MFGYATDET+ECMPLT++LAH LN K+ E  +N    ++ PD+K+QVTV Y+   G   P++VHT+VIS QH  +I ++++RK+LME VVKTVIP KYLD  TIYHL PSG+F+IGGPQ        RKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLSI V  YGT +  + +LLEI+  NFDLRPG I K+L L+RPIYQKTA YGHFGR EF WE+PK L +
Sbjct:   11 KTFLFTSESVGQGHSDKMCDQISDAVLDAYLSQDPDAKVACECVAKTGMILLCGEVTSKAVVDLEKVVRDTVKDIGYDDSSKGFDYKTCNVLVALQPQCEEITDCVFEGRDEEDIGAGDQGFMFGYATDETDECMPLTILLAHKLNHKMKELSKNGECAWILPDSKSQVTVEYRDNMGVMEPIRVHTVVISVQHTPDITLSEIRKNLMEKVVKTVIPAKYLDDRTIYHLLPSGKFLIGGPQVKKCRPYWRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSISVFHYGTSTRDEDELLEIVQKNFDLRPGVIVKELGLKRPIYQKTASYGHFGREEFPWEKPKKLVF 391

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BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Match: SAM2 (S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon [Source:SGD;Acc:S000002910])

HSP 1 Score: 514.998 bits (1325), Expect = 0.000e+0
Identity = 252/380 (66.32%), Postives = 308/380 (81.05%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDA+LDA L QDP +KVACET +KTGMI++ GEIT+ A ++YQ+++R TIK IG+D   KGFDYKTCN+L+AIEQQ+P+IAQ +H E+S ED+GAGDQG+MFGYATDET E +PLT++LAH LNM +A+ RR+ +LP+LRPDTKTQVTV Y+  NG  +P ++ T+VIS QH + I    LR  L + +V+ VIP+  LD +T Y + PSGRFVIGGPQGDAGLTGRKIIVD YGG  + GGGAFSGKDYSKVDRS AYAARWVAKSLV AGLC+RV VQ SYAIGIA PLS+ VD+YGT +  D +++EII  NFDLRPG + K+LDL RPIY  TA YGHF   E++WE+PK L++
Sbjct:    5 KTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF 384

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BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Match: SAM1 (S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication [Source:SGD;Acc:S000004170])

HSP 1 Score: 514.612 bits (1324), Expect = 0.000e+0
Identity = 251/379 (66.23%), Postives = 306/379 (80.74%), Query Frame = 1

Query:  172 TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            TFLFTSESVGEGHPDKICDQVSDA+LDA L++DP +KVACET +KTGMI++ GEIT+ A ++YQ+++R TIK IG+D   KGFDYKTCN+L+AIEQQ+P+IAQ VHEE+  EDIGAGDQG+MFGYATDET E +PLT++LAH LNM +A+ RR+ +L +LRPDTKTQVTV YK  +G  +P ++ T+V+S QH + I    LR  L   +++ VIP   LD +T Y + PSGRFVIGGPQGDAGLTGRKIIVD YGG  + GGGAFSGKDYSKVDRS AYAARWVAKSLV AGLC+RV VQ SYAIGIA PLS+ VD+YGT +  D ++++II+ NFDLRPG + K+LDL RPIY  TA YGHF   E+ WE+PKTLK+
Sbjct:    4 TFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF 382

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BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO37850 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7SEP5])

HSP 1 Score: 561.607 bits (1446), Expect = 0.000e+0
Identity = 284/406 (69.95%), Postives = 331/406 (81.53%), Query Frame = 1

Query:   91 NFT*TNAGFRVYKMRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +FT +N      K +  P    N    TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITSNA+V+YQ V+RQ IKDIG+D  EKGFDYKTCN+L+A+EQQ+ +IA  VH  R +ED+GAGDQGLMFGYATDETEE MPLTVVLAH +N KLAE RR+ TLP+ RPD+KTQVTV YK  +G  IPL+VHTIVIS QHD  I +  LRK+LME +VKTV+P K+LD  TI+HL PSG FVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARW+AKSLV  GLC+RVLVQ+SYAIGIA PLS+ V SYGT    + +LL+I+ DNFDLRPG I K+LDL++P+YQK+  YGHF +P FTWE PK L+Y
Sbjct:    6 DFTFSNGAPPSKKYKMEPLDTQN---NTFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSNAVVDYQSVVRQCIKDIGYDDSEKGFDYKTCNVLVALEQQSVDIAHGVHVGREEEDVGAGDQGLMFGYATDETEELMPLTVVLAHKMNQKLAEYRRDGTLPWARPDSKTQVTVEYKFEHGRAIPLRVHTIVISVQHDPTITMENLRKELMEKIVKTVVPSKFLDEDTIFHLQPSGLFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWIAKSLVSEGLCKRVLVQISYAIGIAQPLSVTVFSYGTSKKSEDELLKIVRDNFDLRPGKIVKELDLKKPVYQKSCVYGHF-KPGFTWETPKPLQY 407

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BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO37825 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7SEP6])

HSP 1 Score: 555.444 bits (1430), Expect = 0.000e+0
Identity = 280/391 (71.61%), Postives = 329/391 (84.14%), Query Frame = 1

Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            + P++++N    TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACE+ +KTGMI++ GEITS A V+YQ+V+R TIK IG+D   KGFDYKTC +L AIEQQ+P+IAQ VH  RSDED+GAGDQGLMFGYATDET+E MPLTVVLAHGLN +LA+CRRN +LP++RPD+KTQVTV YK   G  +PL+VHTIVIS QHD NI ++ +RK+LM++VVK V+PEKY+D  T+YH+ PSG FVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD SKVDRS AYAARW+AKSLV A LC RVLVQLSYAIG+A PLSI V +YGTG  P+ +LLE+I  NFDLRPG I +DLDL++PIYQ T  YGHF +P F WE PK LKY
Sbjct:    2 NTPDTLNN----TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACESVAKTGMIVVCGEITSLANVDYQKVVRDTIKQIGYDDSSKGFDYKTCTVLQAIEQQSPDIAQGVHIGRSDEDLGAGDQGLMFGYATDETDELMPLTVVLAHGLNKRLADCRRNGSLPWVRPDSKTQVTVEYKFQGGKAVPLRVHTIVISVQHDPNIELDVMRKELMDYVVKEVVPEKYIDNDTVYHMQPSGSFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAKLCHRVLVQLSYAIGVAEPLSISVFTYGTGYRPEEELLEVIKHNFDLRPGVIVRDLDLKKPIYQSTCLYGHF-KPGFPWEVPKPLKY 387

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO45117 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7RTZ9])

HSP 1 Score: 509.99 bits (1312), Expect = 4.402e-180
Identity = 260/379 (68.60%), Postives = 310/379 (81.79%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            + FLFTSESV EGH DK+CDQ+SDAVLDAHL QDP AKVACET +KTG++L+ GEITSNA V+YQ V+R TI+DIG++    GFDYKTC++L+AI++Q  EIAQ+VH  R D++IGAGDQGLMFGYATDETEE MPLT VLAH L  +LAECR+   LP+L PD KTQVTV Y+   GACIP +VHT++ISTQH  ++ I ++R  L E ++  VIPEKYLD  TI+HL PSG+F+ GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRSGAYA RW+AKSLV AGLCRRVLVQ++YAIGIA PLSI V SYG+G+  D QLL +I DNFDLRPG I +DL+L RPIY+ T+ +GHF +P F WE+PK LK
Sbjct:   50 DNFLFTSESVNEGHSDKMCDQISDAVLDAHLEQDPYAKVACETATKTGLVLLFGEITSNARVDYQAVVRNTIRDIGYNDSSTGFDYKTCSVLLAIQEQVAEIAQTVHLNRRDDEIGAGDQGLMFGYATDETEELMPLTTVLAHKLCARLAECRKGKILPWLLPDGKTQVTVDYRLERGACIPERVHTVLISTQHTPDVGIEEIRHHLKETIINHVIPEKYLDDKTIFHLLPSGQFIDGGPLGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDVTKVDRSGAYACRWIAKSLVAAGLCRRVLVQVAYAIGIAEPLSISVFSYGSGNYTDKQLLGVIKDNFDLRPGVIIRDLNLLRPIYKATSTFGHF-KPGFPWEEPKKLK 427

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO26870 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAU6])

HSP 1 Score: 207.994 bits (528), Expect = 4.552e-65
Identity = 117/212 (55.19%), Postives = 154/212 (72.64%), Query Frame = 1

Query:  451 IEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYA 1086
            I +Q+ +I Q V   +  ED GAGDQGLMFGYAT+ET+  MP  V  AH L  + +E RRN TLP+LRPD K+QVT+ ++  +      KV  +V+STQHD +I ++ LR+ ++E+++K V+P ++L   T+YH+NP+G FVIGGP GDAGLTGRKIIVDTYGG   HGGGAFSGKD SKVDRS AY  R+VAK++V A L  +  +Q+SYA
Sbjct:    1 IGKQSVDINQGVDRAKP-EDQGAGDQGLMFGYATNETDSLMPAPVYYAHRLVERQSELRRNGTLPWLRPDAKSQVTINWEGDS-----PKVDAVVLSTQHDPSISLDDLREAVLENIIKPVLPAEWLHEGTLYHINPTGNFVIGGPVGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYIGRYVAKNIVAAELADKCEIQVSYA 206

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat2ab (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101160913])

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 284/395 (71.90%), Postives = 328/395 (83.04%), Query Frame = 1

Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN    E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R TI+ IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +RS+E+IGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHDE+I + ++R  L E V+K V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DLDL++P YQKTA YGHFGR  F WE PK LKY
Sbjct:    2 MNGQMNGFHNSLIEEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRATVDYQKVVRDTIRQIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHIDRSEEEIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDEDICLEEMRDALKEKVIKAVVPCVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAHPLSISIFHYGTSKKSERELLDIVRKNFDLRPGVIVRDLDLKKPFYQKTAAYGHFGRDSFPWEVPKKLKY 396

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: ENSORLT00000011581.2 (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101171015])

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 278/391 (71.10%), Postives = 329/391 (84.14%), Query Frame = 1

Query:  145 NSIHN---FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+    +++ FLFTSESVGEGHPDKICDQ+SDAVLDAHLSQDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R  I+DIG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +ED+GAGDQGLMFGYATDET+ECMPLT+VLAH LN K+AE RR+ TLP+LRPD+KTQVTV YK   GA +PL+VHTIVIS QHDE + + ++R+ L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG++ PLS+ +  YGT    + +LL+I+  NFDLRPG I ++LDL++PIYQ+TA YGHFGR  F+WE PK LKY
Sbjct:    2 NGFHHDLLHDKDCFLFTSESVGEGHPDKICDQISDAVLDAHLSQDPDAKVACETVAKTGMILLAGEITSRAKVDYQKVVRDAIRDIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRKEEDVGAGDQGLMFGYATDETDECMPLTIVLAHKLNAKMAELRRDGTLPWLRPDSKTQVTVQYKQDRGAVVPLRVHTIVISVQHDECVCLEEMRRCLKEQVVKAVVPSGYLDDETIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSNLCRRVLVQVSYAIGVSHPLSVSIFHYGTSQRSERELLDIVMKNFDLRPGVIVRELDLKKPIYQRTAAYGHFGRDVFSWEMPKKLKY 392

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101160342])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 276/383 (72.06%), Postives = 327/383 (85.38%), Query Frame = 1

Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
             ++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN T+P+LRPD+KTQVTV Y+  +GA IP +VHTIVIS QHD+ + + + +K L E V+K V+P KYLD  TI HL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PLSI + +YG+    +S+LL+I+N NFDLRPG I +DL L+RPIYQ+TA YGHFGR EF+WE PK L +
Sbjct:    5 LDDNSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHVDRQEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTVPWLRPDSKTQVTVHYEQKDGAVIPKRVHTIVISVQHDDGVTLEEQQKALKEKVIKAVVPAKYLDDKTICHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQVSYAIGVAQPLSISLFTYGSSKKTESELLKIVNKNFDLRPGVIVRDLQLKRPIYQQTAAYGHFGRSEFSWEVPKKLVF 387

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: ENSORLT00000016106.2 (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101159865])

HSP 1 Score: 553.518 bits (1425), Expect = 0.000e+0
Identity = 270/382 (70.68%), Postives = 324/382 (84.82%), Query Frame = 1

Query:  163 NEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +E  FLFTSESVGEGHPDK+CDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R  IK IG+DS  KG DYKTCN+L+A+E+Q+P+IAQ VH +R + +IGAGDQGLMFGYATDETEECMPLT+VLAH LN ++AE RRN T+P+LRPD+KTQVTV Y   +GA IP ++HT+VIS QHD+++ + + R  LME V++ VIP KYLD +T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LCRRVLVQ++YAIG+A PLSI + ++G+    + +LL+I+  NFDLRPG I +DLDL+RPIYQKTACYGHFGR EF WE PK L++
Sbjct:   16 DEGAFLFTSESVGEGHPDKMCDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRASVDYQKVVRDVIKHIGYDSSSKGLDYKTCNVLVALEEQSPDIAQGVHVDRMESEIGAGDQGLMFGYATDETEECMPLTIVLAHKLNARMAELRRNGTVPWLRPDSKTQVTVHYSQESGAVIPERIHTVVISVQHDDHVSLEEQRSVLMEKVIRAVIPAKYLDENTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVNARLCRRVLVQVAYAIGVAHPLSISLFTFGSSQKSEKELLQIVYRNFDLRPGVIVRDLDLKRPIYQKTACYGHFGRKEFPWEVPKNLEF 397

[Close]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat2al (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101170772])

HSP 1 Score: 525.013 bits (1351), Expect = 0.000e+0
Identity = 264/380 (69.47%), Postives = 310/380 (81.58%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+LSQDP +KVACE  +KTGMIL+ GE+TS A V+ Q V+R TIK IG+DS  KGFDYKTCN+L+A+E Q  EI+  V E R+ EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  RN   P++ PD K+QVTV Y+   GA  PL+VHT+VIS QH  +I + ++R +LME VVK VIP KYLD  T+YHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRR LVQ+SY+I ++ PLSI V  YGT S  + +LL+I+ DNFDLRPG I  +L L+RPIYQ TACYGHFGR EF WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLSQDPDSKVACECVAKTGMILLVGEVTSRAKVDLQAVVRNTIKKIGYDSSSKGFDYKTCNVLVALEPQAQEISDCVFEGRNQEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNHKMKELSRNGDCPWILPDCKSQVTVEYRDDAGAMEPLRVHTVVISVQHSPDISLEEIRHNLMEKVVKAVIPAKYLDDQTVYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRALVQISYSIAVSHPLSITVFHYGTSSRDEDELLQIVKDNFDLRPGVIVTELGLKRPIYQATACYGHFGREEFPWEKPKPLVF 390

[Close]

BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000053202.1 (SMESG000053202.1)

HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0
Identity = 393/393 (100.00%), Postives = 393/393 (100.00%), Query Frame = 1

Query:  130 MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY
Sbjct:    1 MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 393

[Close]

BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000027587.1 (SMESG000027587.1)

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 301/382 (78.80%), Postives = 344/382 (90.05%), Query Frame = 1

Query:  163 NEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +  TFLFTSESVGEGHPDKICDQ+SDA+LDAHL QDP AKVACETF+KTGMIL+GGEI+S A+V+YQ+V+R+TIK+IG+D CEKGFDYKTCN+L+AIE+Q+P+IAQ VH ER  ++IGAGDQGLMFGYATDET ECMPLTVVLAH LN +L+ECRRN TLP+LRPDTKTQVTV YKS NGACIPL+VHT+VISTQHDE I    L++ L++ ++K VIPE YLD  TIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI+VDSYGT S  D++LL I+ DNFDLRPGHI K+L+LR PIY+KTACYGHFGR EFTWE+PK LK+
Sbjct:    5 SSNTFLFTSESVGEGHPDKICDQISDAILDAHLKQDPNAKVACETFAKTGMILVGGEISSKAVVDYQKVVRETIKEIGYDHCEKGFDYKTCNVLLAIEEQSPDIAQGVHLERDFDNIGAGDQGLMFGYATDETAECMPLTVVLAHALNKRLSECRRNGTLPWLRPDTKTQVTVEYKSDNGACIPLRVHTVVISTQHDETISHQHLQQCLIKEIIKKVIPEHYLDEETIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAHPLSIYVDSYGTSSHSDAELLRIVVDNFDLRPGHIVKELNLRHPIYKKTACYGHFGREEFTWEKPKKLKF 386

[Close]

BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000013953.1 (SMESG000013953.1)

HSP 1 Score: 567.385 bits (1461), Expect = 0.000e+0
Identity = 277/380 (72.89%), Postives = 324/380 (85.26%), Query Frame = 1

Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            + FLFTSESVGEGHPDKICDQ+SDA+LDAHL QDP AKVACE+F+KTGM+L+GGEITS+A+VNY  ++R TIK IGFDS EKG DY+TCN+L+AIEQQ+P+IAQ V+  RS++ IGAGDQGLMFGYATDETEECMP+T++LAH LN +LA CRRN+ L +LRPDTKTQVT+ YK+ +G  +PL VHTIVIS QHDE + +  ++ DLM+HV+  VI  K L +STIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVK GLC+RVLVQ SYAIGIAAPLSIFV SY + +  D++LL I+N NFDLRPG I +DL LR PI++KTA YGHFGR EF WE PK L +
Sbjct:    5 DIFLFTSESVGEGHPDKICDQISDAILDAHLKQDPYAKVACESFTKTGMVLVGGEITSHAVVNYSDIVRNTIKRIGFDSSEKGLDYRTCNVLVAIEQQSPDIAQGVYVNRSEDSIGAGDQGLMFGYATDETEECMPMTLILAHKLNQRLAYCRRNDILGWLRPDTKTQVTIAYKNKDGGLLPLYVHTIVISAQHDEEVTLENIKSDLMKHVISNVIDSKMLTSSTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDATKVDRSAAYAARWVAKSLVKNGLCKRVLVQFSYAIGIAAPLSIFVYSYNSSTKTDNELLAIVNQNFDLRPGAIIRDLKLREPIFEKTASYGHFGRNEFLWENPKKLHF 384

The following BLAST results are available for this feature:

BLAST of S-adenosylmethionine synthase vs. Ensembl Human
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
BLAST of S-adenosylmethionine synthase vs. TrEMBL
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
BLAST of S-adenosylmethionine synthase vs. Ensembl Sea Lamprey
BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
BLAST of S-adenosylmethionine synthase vs. Planmine SMEST

BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
MAT2A	0.000e+0	72.66	methionine adenosyltransferase 2A [Source:HGNC Sym...	[more]
MAT1A	0.000e+0	70.91	methionine adenosyltransferase 1A [Source:HGNC Sym...	[more]
MAT2A	1.431e-149	72.39	methionine adenosyltransferase 2A [Source:HGNC Sym...	[more]
MAT1A	1.154e-70	58.06	methionine adenosyltransferase 1A [Source:HGNC Sym...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
sams-3	0.000e+0	68.06	Probable S-adenosylmethionine synthase 3 [Source:...	[more]
sams-4	0.000e+0	68.68	Probable S-adenosylmethionine synthase 4 [Source:...	[more]
sams-4	0.000e+0	68.68	Probable S-adenosylmethionine synthase 4 [Source:...	[more]
sams-5	0.000e+0	67.54	Probable S-adenosylmethionine synthase 5 [Source:...	[more]
sams-5	0.000e+0	67.54	Probable S-adenosylmethionine synthase 5 [Source:...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Sam-S	0.000e+0	68.46	gene:FBgn0005278 transcript:FBtr0089430	[more]
Sam-S	0.000e+0	68.46	gene:FBgn0005278 transcript:FBtr0089433	[more]
Sam-S	0.000e+0	68.46	gene:FBgn0005278 transcript:FBtr0089432	[more]
Sam-S	0.000e+0	68.46	gene:FBgn0005278 transcript:FBtr0089429	[more]
Sam-S	0.000e+0	68.46	gene:FBgn0005278 transcript:FBtr0089434	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mat2aa	0.000e+0	71.39	methionine adenosyltransferase II, alpha a [Source...	[more]
mat1a	0.000e+0	71.83	methionine adenosyltransferase I, alpha [Source:ZF...	[more]
mat1a	0.000e+0	71.83	methionine adenosyltransferase I, alpha [Source:ZF...	[more]
mat2al	0.000e+0	68.68	methionine adenosyltransferase II, alpha-like [Sou...	[more]
mat2al	0.000e+0	68.68	methionine adenosyltransferase II, alpha-like [Sou...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mat1a	0.000e+0	73.35	methionine adenosyltransferase I, alpha [Source:NC...	[more]
use1	0.000e+0	71.03	unconventional SNARE in the ER 1 homolog [Source:X...	[more]
use1	0.000e+0	71.03	unconventional SNARE in the ER 1 homolog [Source:X...	[more]
mat1a	0.000e+0	72.73	methionine adenosyltransferase I, alpha [Source:NC...	[more]
use1	0.000e+0	68.21	unconventional SNARE in the ER 1 homolog [Source:X...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Mat2a	0.000e+0	72.66	methionine adenosyltransferase II, alpha [Source:M...	[more]
Mat2a	0.000e+0	72.66	methionine adenosyltransferase II, alpha [Source:M...	[more]
Mat1a	0.000e+0	72.02	methionine adenosyltransferase I, alpha [Source:MG...	[more]
Mat1a	0.000e+0	72.02	methionine adenosyltransferase I, alpha [Source:MG...	[more]
Mat2a	0.000e+0	72.53	methionine adenosyltransferase II, alpha [Source:M...	[more]

BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5R5H1\|METK2_PONAB	0.000e+0	72.66	S-adenosylmethionine synthase isoform type-2 OS=Po...	[more]
sp\|Q3THS6\|METK2_MOUSE	0.000e+0	72.66	S-adenosylmethionine synthase isoform type-2 OS=Mu...	[more]
sp\|Q4R924\|METK2_MACFA	0.000e+0	72.66	S-adenosylmethionine synthase isoform type-2 OS=Ma...	[more]
sp\|P31153\|METK2_HUMAN	0.000e+0	72.66	S-adenosylmethionine synthase isoform type-2 OS=Ho...	[more]
sp\|P18298\|METK2_RAT	0.000e+0	72.41	S-adenosylmethionine synthase isoform type-2 OS=Ra...	[more]

BLAST of S-adenosylmethionine synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8I605	0.000e+0	77.63	S-adenosylmethionine synthase OS=Macrostomum ligna...	[more]
A0A1I8HKQ4	0.000e+0	77.63	S-adenosylmethionine synthase OS=Macrostomum ligna...	[more]
A0A267DP28	0.000e+0	77.37	S-adenosylmethionine synthase OS=Macrostomum ligna...	[more]
A0A267H2L8	0.000e+0	76.32	S-adenosylmethionine synthase OS=Macrostomum ligna...	[more]
A0A267EMZ1	0.000e+0	76.05	S-adenosylmethionine synthase OS=Macrostomum ligna...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mat2ab	0.000e+0	70.96	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat1a	0.000e+0	71.83	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat1a	0.000e+0	69.85	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat2aa	0.000e+0	71.39	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat2al	6.113e-176	66.93	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
SAM2	0.000e+0	66.32	S-adenosylmethionine synthetase; catalyzes transfe...	[more]
SAM1	0.000e+0	66.23	S-adenosylmethionine synthetase; catalyzes transfe...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4


Match Name	E-value	Identity	Description
EDO37850	0.000e+0	69.95	S-adenosylmethionine synthase [Source:UniProtKB/T...	[more]
EDO37825	0.000e+0	71.61	S-adenosylmethionine synthase [Source:UniProtKB/T...	[more]
EDO45117	4.402e-180	68.60	S-adenosylmethionine synthase [Source:UniProtKB/T...	[more]
EDO26870	4.552e-65	55.19	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mat2ab	0.000e+0	71.90	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
ENSORLT00000011581.2	0.000e+0	71.10	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat1a	0.000e+0	72.06	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
ENSORLT00000016106.2	0.000e+0	70.68	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]
mat2al	0.000e+0	69.47	S-adenosylmethionine synthase [Source:NCBI gene;Ac...	[more]

BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000053202.1	0.000e+0	100.00	SMESG000053202.1	[more]
SMESG000027587.1	0.000e+0	78.80	SMESG000027587.1	[more]
SMESG000013953.1	0.000e+0	72.89	SMESG000013953.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30021445 ID=SMED30021445|Name=S-adenosylmethionine synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1392bp
CATTCATGTGTTGAATATTCATAATCATTCAAAAAAGTTATCGCCTGGAC
TATGACTTATGAAAGTAGCATATGTAGTAAAATTACTTAAAACTTTACTT
GAACTAATGCAGGTTTTAGAGTATACAAAATGAGATCGAATCCAAACTCA
ATTCACAATTTTAATGAAGAAACATTTCTGTTTACTTCAGAATCTGTAGG
CGAAGGACATCCAGATAAAATATGTGACCAAGTTAGTGACGCCGTTCTTG
ATGCCCACCTTTCTCAGGACCCAAAAGCTAAAGTGGCTTGTGAGACGTTT
TCTAAAACCGGAATGATCCTAATCGGAGGAGAAATAACTTCTAATGCCAT
TGTCAATTATCAAAGAGTCATAAGACAAACAATTAAAGACATTGGTTTTG
ACAGTTGCGAGAAGGGTTTCGATTATAAAACATGCAATTTGTTGATAGCG
ATAGAGCAACAAAATCCGGAAATCGCACAAAGCGTTCATGAAGAAAGATC
GGATGAGGATATTGGTGCAGGCGATCAAGGTCTAATGTTTGGTTATGCAA
CCGATGAAACGGAAGAATGTATGCCACTGACAGTTGTATTAGCTCATGGA
TTAAATATGAAACTAGCTGAATGTCGAAGAAACAATACTCTACCATATTT
ACGACCTGATACAAAAACCCAGGTAACTGTCCTGTATAAGTCAGTTAATG
GGGCATGTATACCTTTAAAAGTTCATACCATTGTAATTTCAACTCAACAC
GATGAAAATATACACATAAATCAACTTCGTAAAGATTTAATGGAGCATGT
TGTAAAAACCGTAATTCCTGAAAAGTATTTAGACGCTAGTACAATATACC
ATTTAAATCCATCAGGGAGATTTGTAATTGGTGGGCCACAAGGTGACGCA
GGTTTAACTGGTAGAAAAATTATTGTGGATACTTATGGTGGTTGGGGAGC
TCATGGTGGAGGAGCCTTTTCTGGAAAGGACTATTCAAAAGTCGATCGTA
GCGGAGCATACGCCGCTAGATGGGTAGCAAAGTCATTAGTCAAAGCAGGA
CTTTGTCGAAGGGTACTTGTTCAACTGTCATATGCCATTGGTATTGCTGC
TCCTTTGTCAATTTTTGTCGATAGCTATGGAACAGGTTCCATACCAGATT
CACAATTGTTAGAGATTATAAATGATAATTTTGACCTTCGACCTGGCCAC
ATAGAAAAAGACTTGGATCTTCGAAGACCAATTTATCAGAAGACTGCCTG
CTATGGACATTTTGGAAGACCAGAGTTTACATGGGAACAACCAAAAACAT
TGAAATATTAACATTTGTTCAGCTAATTTAAATATAATTAATAATGTGTA
ATTTATTGATATATAAACATGAGATACACAAAATAAGATGAT

protein sequence of SMED30021445-orf-1

>SMED30021445-orf-1 ID=SMED30021445-orf-1|Name=SMED30021445-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=394bp
MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKA
KVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYK
TCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPL
TVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHT
IVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVI
GGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVA
KSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDN
FDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000070	intestinal phagocyte
PLANA:0002075	pigment cell
PLANA:0003108	gastrodermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR022630	S-AdoMet_synt_C
IPR002133	S-AdoMet_synthetase
IPR022628	S-AdoMet_synt_N
IPR022629	S-AdoMet_synt_central
IPR022631	ADOMET_SYNTHASE_CS
IPR022636	S-AdoMet_synthetase_sfam

Vocabulary: **biological process**
Term	Definition
GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006730	one-carbon metabolic process

Vocabulary: **molecular function**
Term	Definition
GO:0004478	methionine adenosyltransferase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0016740	transferase activity
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR022629	S-adenosylmethionine synthetase, central domain	PFAM	PF02772	S-AdoMet_synt_M	coord: 128..248 e-value: 1.3E-45 score: 154.5
IPR022628	S-adenosylmethionine synthetase, N-terminal	PFAM	PF00438	S-AdoMet_synt_N	coord: 16..113 e-value: 2.8E-40 score: 137.0
IPR022630	S-adenosylmethionine synthetase, C-terminal	PFAM	PF02773	S-AdoMet_synt_C	coord: 250..387 e-value: 1.9E-68 score: 228.7
None	No IPR available	GENE3D	G3DSA:3.30.300.10		coord: 17..252 e-value: 2.1E-172 score: 575.2
None	No IPR available	GENE3D	G3DSA:3.30.300.10		coord: 127..386 e-value: 2.1E-172 score: 575.2
None	No IPR available	GENE3D	G3DSA:3.30.300.10		coord: 23..289 e-value: 2.1E-172 score: 575.2
None	No IPR available	PANTHER	PTHR11964:SF12	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2	coord: 11..393
None	No IPR available	CDD	cd18079	S-AdoMet_synt	coord: 17..389 e-value: 0.0 score: 691.067
IPR002133	S-adenosylmethionine synthetase	PIRSF	PIRSF000497	MAT	coord: 10..393 e-value: 2.3E-165 score: 547.8
IPR002133	S-adenosylmethionine synthetase	TIGRFAM	TIGR01034	TIGR01034	coord: 17..392 e-value: 1.7E-178 score: 591.3
IPR002133	S-adenosylmethionine synthetase	PANTHER	PTHR11964	S-ADENOSYLMETHIONINE SYNTHETASE	coord: 11..393
IPR022631	S-adenosylmethionine synthetase, conserved site	PROSITE	PS00376	ADOMET_SYNTHASE_1	coord: 129..139
IPR022631	S-adenosylmethionine synthetase, conserved site	PROSITE	PS00377	ADOMET_SYNTHASE_2	coord: 276..284
IPR022636	S-adenosylmethionine synthetase superfamily	SUPERFAMILY	SSF55973	S-adenosylmethionine synthetase	coord: 125..249
IPR022636	S-adenosylmethionine synthetase superfamily	SUPERFAMILY	SSF55973	S-adenosylmethionine synthetase	coord: 15..122
IPR022636	S-adenosylmethionine synthetase superfamily	SUPERFAMILY	SSF55973	S-adenosylmethionine synthetase	coord: 250..392

Main menu

S-adenosylmethionine synthase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Owlery

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