S-adenosylmethionine synthase

Overview
NameS-adenosylmethionine synthase
Smed IDSMED30021445
Length (bp)1392
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of S-adenosylmethionine synthase (SMED30021445) t-SNE clustered cells

Violin plots show distribution of expression levels for S-adenosylmethionine synthase (SMED30021445) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of S-adenosylmethionine synthase (SMED30021445) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for S-adenosylmethionine synthase (SMED30021445) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30021445

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 15

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30021445h1SMcG0005079 EG413862smed_ncbi_20240424PMID:23318641
Chen et al., 2013
whole organism asexual adult fluorescence in situ hybridization evidence
intestinal phagocyteSMED30021445h1SMcG0002915 Contig5554GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30021445h1SMcG0005079 Contig5554GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pigment cellSMED30021445h1SMcG0005079 SmedASXL_006595SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30021445h1SMcG0002915 Contig5554GPL15192PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021445h1SMcG0005079 Contig5554GPL15192PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021445h1SMcG0005079 Contig39602uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021445h1SMcG0005079 Contig39602newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30021445h1SMcG0005079 dd_Smed_v4_907_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30021445h1SMcG0005079 dd_Smed_v4_907_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult fluorescence in situ hybridization evidence
cephalic gangliaSMED30021445h1SMcG0005079 dd_Smed_v4_907_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30021445h1SMcG0005079 dd_Smed_v4_907_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30021445h1SMcG0005079 dd_Smed_v4_907_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30021445h1SMcG0005079 EG413862smed_ncbi_20240424PMID:21566185
Wagner et al., 2011
whole organism asexual adult fluorescence in situ hybridization evidence
gastrodermal cellSMED30021445h1SMcG0005079 EG413862smed_ncbi_20240424PMID:21566185
Wagner et al., 2011
whole organism asexual adult fluorescence in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT2A (methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT1A (methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 273/385 (70.91%), Postives = 331/385 (85.97%), Query Frame = 1
Query:  154 HNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +E  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT++LAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I + ++R+ L E V++ V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT    + +LL++++ NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE P+ L +
Sbjct:   11 HSLSEGVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRKLVF 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT2A (methionine adenosyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:6904])

HSP 1 Score: 429.483 bits (1103), Expect = 1.431e-149
Identity = 215/297 (72.39%), Postives = 251/297 (84.51%), Query Frame = 1
Query:  313 MILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHI 1203
            MIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I
Sbjct:    1 MILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI 297          
BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Match: MAT1A (methionine adenosyltransferase 1A [Source:HGNC Symbol;Acc:HGNC:6903])

HSP 1 Score: 222.246 bits (565), Expect = 1.154e-70
Identity = 108/186 (58.06%), Postives = 130/186 (69.89%), Query Frame = 1
Query:  190 ESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQ 747
            ESVGEGHPDKICDQ+SDAVLDAHL QDP AKVAC                                         GFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT++LAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS Q
Sbjct:    1 ESVGEGHPDKICDQISDAVLDAHLKQDPNAKVAC-----------------------------------------GFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQ 145          
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-3 (Probable S-adenosylmethionine synthase 3 [Source:UniProtKB/Swiss-Prot;Acc:P50305])

HSP 1 Score: 531.946 bits (1369), Expect = 0.000e+0
Identity = 260/382 (68.06%), Postives = 318/382 (83.25%), Query Frame = 1
Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVK+GLCRR LVQ+SYAIG+A PLS+ V S+GT ++ + +LL+I+NDNFDLRPG I KDLDL++PIY+ TA  GHFG  EF WEQP+ L+
Sbjct:    1 MSQHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKSGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEGELLKIVNDNFDLRPGMIIKDLDLKKPIYEPTAENGHFGHNEFPWEQPRHLQ 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-4 (Probable S-adenosylmethionine synthase 4 [Source:UniProtKB/Swiss-Prot;Acc:P50306])

HSP 1 Score: 531.561 bits (1368), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 314/380 (82.63%), Query Frame = 1
Query:  166 EETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            +  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +  LL I+NDNFDLRPG I K+LDL+RPIY+ TA  GHFG   F WEQP+ LK
Sbjct:    3 QHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-4 (Probable S-adenosylmethionine synthase 4 [Source:UniProtKB/Swiss-Prot;Acc:P50306])

HSP 1 Score: 531.561 bits (1368), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 314/380 (82.63%), Query Frame = 1
Query:  166 EETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            +  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++  +D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I ++ LRK+L+E V+K VIP   +D  TIYHLNP G F+IGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +  LL I+NDNFDLRPG I K+LDL+RPIY+ TA  GHFG   F WEQP+ LK
Sbjct:    3 QHKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQVTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIKAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALSEEDLLTIVNDNFDLRPGKIIKNLDLKRPIYEPTAENGHFGHNNFPWEQPRNLK 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-5 (Probable S-adenosylmethionine synthase 5 [Source:UniProtKB/Swiss-Prot;Acc:Q27522])

HSP 1 Score: 524.628 bits (1350), Expect = 0.000e+0
Identity = 258/382 (67.54%), Postives = 315/382 (82.46%), Query Frame = 1
Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++   D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I +  LRK+L+E V+K VIP   +D  T+YHLNP G FV+GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +++LL+I+NDNFDLRPG I K+LDL+R IY+ TA  GHFG  +F WEQ + LK
Sbjct:    1 MSKNKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDIADVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELEWVRPDSKTQVTIEYSSEGGACVPLRVHTVVISTQHSPDISLEDLRKELIEKVIKVVIPGNLIDNDTVYHLNPCGSFVVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEAELLKIVNDNFDLRPGMIIKNLDLKRAIYEPTAENGHFGHNDFPWEQARKLK 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Match: sams-5 (Probable S-adenosylmethionine synthase 5 [Source:UniProtKB/Swiss-Prot;Acc:Q27522])

HSP 1 Score: 524.628 bits (1350), Expect = 0.000e+0
Identity = 258/382 (67.54%), Postives = 315/382 (82.46%), Query Frame = 1
Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
             ++  FLFTSESV EGHPDK+CDQ+SDAVLDAHL+QDP AKVACET +KTGMI++ GEITS A+V+YQ ++R  IK IG+D   KGFDYKTCN+L+A+EQQ+PEIA  VH ++   D+GAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+  L ++RPD+KTQVT+ Y S  GAC+PL+VHT+VISTQH  +I +  LRK+L+E V+K VIP   +D  T+YHLNP G FV+GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVKAGLCRR LVQ+SYAIG+A PLS+ V S+GT ++ +++LL+I+NDNFDLRPG I K+LDL+R IY+ TA  GHFG  +F WEQ + LK
Sbjct:    1 MSKNKFLFTSESVSEGHPDKMCDQISDAVLDAHLAQDPHAKVACETVTKTGMIMLCGEITSKAVVDYQVLVRNVIKKIGYDDSSKGFDYKTCNVLVALEQQSPEIAAGVHVDKDIADVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELEWVRPDSKTQVTIEYSSEGGACVPLRVHTVVISTQHSPDISLEDLRKELIEKVIKVVIPGNLIDNDTVYHLNPCGSFVVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPTKVDRSAAYAARWVAKSLVKAGLCRRCLVQVSYAIGVAKPLSVMVFSFGTSALNEAELLKIVNDNFDLRPGMIIKNLDLKRAIYEPTAENGHFGHNDFPWEQARKLK 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089430)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405          
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089433)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405          
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089432)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405          
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089429)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405          
BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Match: Sam-S (gene:FBgn0005278 transcript:FBtr0089434)

HSP 1 Score: 519.62 bits (1337), Expect = 0.000e+0
Identity = 267/390 (68.46%), Postives = 320/390 (82.05%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            SN NS    +  TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITS A+V+YQ+V+R+T++ IG+D   KGFD+KTCN+L+A++QQ+PEIA  VH  R++E+IGAGDQG+MFGYATDETEECMPLTVVLAH LN K+AE RR++   + RPD+KTQVT  Y    G+ +P +VHTIV+S QH E I +  LR ++ME VVK VIP KY+DA+TI H+NP G FVIGGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD++KVDRS AYAARWVAKSLVKAGLC+R LVQ+SYAIG+A PLSI V  YGT      +LL+II  NFDLRPG I KDL+LR+PIYQ+T+ YGHFGR  F+WE+ K L+
Sbjct:   16 SNGNSYDMEDGATFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405          
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat2aa (methionine adenosyltransferase II, alpha a [Source:ZFIN;Acc:ZDB-GENE-030131-2049])

HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0
Identity = 282/395 (71.39%), Postives = 332/395 (84.05%), Query Frame = 1
Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN   +E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS+A+V+YQ+V+R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHD+ + ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLC+RVLVQ+SYAIG+A PLS+ +  YGT    + +LLEI+  NFDLRPG I ++LDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHNSLIDEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSHAVVDYQKVVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDDVVCLDEMRDALKEKVVKAVVPNVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCKRVLVQVSYAIGVAHPLSVSIFHYGTSQRSEKELLEIVKKNFDLRPGVIVRELDLKKPIYQRTAAYGHFGRESFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat1a (methionine adenosyltransferase I, alpha [Source:ZFIN;Acc:ZDB-GENE-030131-6127])

HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0
Identity = 278/387 (71.83%), Postives = 330/387 (85.27%), Query Frame = 1
Query:  145 NSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            N +H+  + +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+++R TIK IG+D+ EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+NI + + ++ L E V+K V+P +YLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG+A PLSI + +YG+    + +LL I+N NFDLRPG I +DL+L+RP YQ TACYGHFGR EF WE  KTLK
Sbjct:    5 NDVHD--DGSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKIVRDTIKHIGYDNSEKGFDYKTCNVLVALEQQSPDIAQGVHVDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDNISLEEQQRILKEKVIKAVVPARYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSKLCRRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLHIVNKNFDLRPGVIVRDLNLKRPFYQNTACYGHFGRSEFPWEMAKTLK 389          
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat1a (methionine adenosyltransferase I, alpha [Source:ZFIN;Acc:ZDB-GENE-030131-6127])

HSP 1 Score: 565.844 bits (1457), Expect = 0.000e+0
Identity = 278/387 (71.83%), Postives = 330/387 (85.27%), Query Frame = 1
Query:  145 NSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            N +H+  + +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+++R TIK IG+D+ EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+NI + + ++ L E V+K V+P +YLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG+A PLSI + +YG+    + +LL I+N NFDLRPG I +DL+L+RP YQ TACYGHFGR EF WE  KTLK
Sbjct:    5 NDVHD--DGSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKIVRDTIKHIGYDNSEKGFDYKTCNVLVALEQQSPDIAQGVHVDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDNISLEEQQRILKEKVIKAVVPARYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSKLCRRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLHIVNKNFDLRPGVIVRDLNLKRPFYQNTACYGHFGRSEFPWEMAKTLK 389          
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat2al (methionine adenosyltransferase II, alpha-like [Source:ZFIN;Acc:ZDB-GENE-060421-5255])

HSP 1 Score: 522.702 bits (1345), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 310/380 (81.58%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+L+QDP ++VACE  SKTGMIL+ GE+TS A+V+ QRV+R T+K IG+D   KGFDYKTCN+L++++ Q  EI+  V E R  EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  +    P++ PD+KTQVTV Y+   GA  P++VHT+VIS QH  +I +  +R +LME VVK VIP KYLD  TIYHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLS+ V  YGT +  +  LLEI+  NFDLRPG I K+LDL++PIYQKTACYGHFGR  F WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLTQDPDSRVACECVSKTGMILLCGEVTSKAVVDLQRVVRDTVKTIGYDDSSKGFDYKTCNVLVSLQPQVSEISDCVFEGRDSEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNYKMKELSKTGVCPWILPDSKTQVTVEYRDNMGAMEPVRVHTVVISVQHSPDITLEDIRHNLMEKVVKAVIPAKYLDDKTIYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSVSVFHYGTSTRDEDDLLEIVKKNFDLRPGVIVKELDLKKPIYQKTACYGHFGREGFPWEKPKKLIF 390          
BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Match: mat2al (methionine adenosyltransferase II, alpha-like [Source:ZFIN;Acc:ZDB-GENE-060421-5255])

HSP 1 Score: 522.702 bits (1345), Expect = 0.000e+0
Identity = 261/380 (68.68%), Postives = 310/380 (81.58%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+L+QDP ++VACE  SKTGMIL+ GE+TS A+V+ QRV+R T+K IG+D   KGFDYKTCN+L++++ Q  EI+  V E R  EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  +    P++ PD+KTQVTV Y+   GA  P++VHT+VIS QH  +I +  +R +LME VVK VIP KYLD  TIYHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLS+ V  YGT +  +  LLEI+  NFDLRPG I K+LDL++PIYQKTACYGHFGR  F WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLTQDPDSRVACECVSKTGMILLCGEVTSKAVVDLQRVVRDTVKTIGYDDSSKGFDYKTCNVLVSLQPQVSEISDCVFEGRDSEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNYKMKELSKTGVCPWILPDSKTQVTVEYRDNMGAMEPVRVHTVVISVQHSPDITLEDIRHNLMEKVVKAVIPAKYLDDKTIYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSVSVFHYGTSTRDEDDLLEIVKKNFDLRPGVIVKELDLKKPIYQKTACYGHFGREGFPWEKPKKLIF 390          
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: mat1a (methionine adenosyltransferase I, alpha [Source:NCBI gene;Acc:100127858])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 278/379 (73.35%), Postives = 326/379 (86.02%), Query Frame = 1
Query:  172 TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
             F+FTSESVGEGHPDKICDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A+V+YQ+++R TIK IG+D  EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN  LP+LRPD+KTQVTV Y   NGA IP++VHTIVIS QHDE I ++ +++ L EHV+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC RVLVQ+SYAIG+A PLS+ + +YGT    + +LL+I+N NFDLRPG I +DLDL++P+YQKTACYGHFGR +F WE PK L +
Sbjct:   18 AFMFTSESVGEGHPDKICDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRAVVDYQKIVRDTIKYIGYDDSEKGFDYKTCNVLVALEQQSPDIAQGVHLDRTEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKLAELRRNGVLPWLRPDSKTQVTVKYIQKNGAVIPVRVHTIVISVQHDETISLSDMQEALKEHVIKAVVPAKYLDEKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVHAKLCHRVLVQVSYAIGVAYPLSVSLFTYGTSEKTEKELLDIVNANFDLRPGVIVRDLDLKKPLYQKTACYGHFGREDFPWEVPKELFF 396          
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 277/390 (71.03%), Postives = 327/390 (83.85%), Query Frame = 1
Query:  145 NSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+   +E +FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    4 NGFHDDLIDEGSFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 393          
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 561.992 bits (1447), Expect = 0.000e+0
Identity = 277/390 (71.03%), Postives = 327/390 (83.85%), Query Frame = 1
Query:  145 NSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+   +E +FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    7 NGFHDDLIDEGSFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 396          
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: mat1a (methionine adenosyltransferase I, alpha [Source:NCBI gene;Acc:100127858])

HSP 1 Score: 537.724 bits (1384), Expect = 0.000e+0
Identity = 264/363 (72.73%), Postives = 311/363 (85.67%), Query Frame = 1
Query:  220 ICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            ICDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A+V+YQ+++R TIK IG+D  EKGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN  LP+LRPD+KTQVTV Y   NGA IP++VHTIVIS QHDE I ++ +++ L EHV+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC RVLVQ+SYAIG+A PLS+ + +YGT    + +LL+I+N NFDLRPG I +DLDL++P+YQKTACYGHFGR +F WE PK L +
Sbjct:    4 ICDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRAVVDYQKIVRDTIKYIGYDDSEKGFDYKTCNVLVALEQQSPDIAQGVHLDRTEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKLAELRRNGVLPWLRPDSKTQVTVKYIQKNGAVIPVRVHTIVISVQHDETISLSDMQEALKEHVIKAVVPAKYLDEKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVHAKLCHRVLVQVSYAIGVAYPLSVSLFTYGTSEKTEKELLDIVNANFDLRPGVIVRDLDLKKPLYQKTACYGHFGREDFPWEVPKELFF 366          
BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Match: use1 (unconventional SNARE in the ER 1 homolog [Source:Xenbase;Acc:XB-GENE-972033])

HSP 1 Score: 529.25 bits (1362), Expect = 0.000e+0
Identity = 266/390 (68.21%), Postives = 316/390 (81.03%), Query Frame = 1
Query:  139 NPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            NP++ H      FLF          +KICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+++R TIK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN ++AE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIV+S QHDE I ++++R  L E +VK V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+GLCRRVLVQ++YAIG++ PLSI +  YGT    + +LL I+  NFDLRPG I +DL+L++PIYQ+TA YGHFGR  F WE PK L+Y
Sbjct:    7 NPSANH------FLFK---------NKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEITSRASVDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDVGAGDQGLMFGYATDETEEGMPLTIVLAHKLNARMAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVVSVQHDETICLDEMRDALKEKIVKAVVPAKYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSGLCRRVLVQVAYAIGVSHPLSISIFHYGTSQKSERELLAIVKKNFDLRPGVIVRDLELKKPIYQRTAAYGHFGRDSFPWEVPKKLEY 381          
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat2a (methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat2a (methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731])

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat1a (methionine adenosyltransferase I, alpha [Source:MGI Symbol;Acc:MGI:88017])

HSP 1 Score: 568.926 bits (1465), Expect = 0.000e+0
Identity = 278/386 (72.02%), Postives = 332/386 (86.01%), Query Frame = 1
Query:  154 HNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +EE  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I +  +++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT +  + +LLE++N NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE PK L +
Sbjct:   11 HSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 396          
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat1a (methionine adenosyltransferase I, alpha [Source:MGI Symbol;Acc:MGI:88017])

HSP 1 Score: 568.926 bits (1465), Expect = 0.000e+0
Identity = 278/386 (72.02%), Postives = 332/386 (86.01%), Query Frame = 1
Query:  154 HNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            H+ +EE  F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A+V+YQRV+R TIK IG+D   KGFD+KTCN+L+A+EQQ+P+IAQ VH +R++ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN ++A+ RR+  LP+LRPD+KTQVTV Y   NGA IP+++HTIVIS QH+E+I +  +++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI + +YGT +  + +LLE++N NFDLRPG I +DLDL++PIYQKTACYGHFGR EF WE PK L +
Sbjct:   11 HSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF 396          
BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Match: Mat2a (methionine adenosyltransferase II, alpha [Source:MGI Symbol;Acc:MGI:2443731])

HSP 1 Score: 520.776 bits (1340), Expect = 0.000e+0
Identity = 264/364 (72.53%), Postives = 303/364 (83.24%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDL 1215
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I + L
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRVL 364          
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q5R5H1|METK2_PONAB (S-adenosylmethionine synthase isoform type-2 OS=Pongo abelii OX=9601 GN=MAT2A PE=2 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q3THS6|METK2_MOUSE (S-adenosylmethionine synthase isoform type-2 OS=Mus musculus OX=10090 GN=Mat2a PE=1 SV=2)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|Q4R924|METK2_MACFA (S-adenosylmethionine synthase isoform type-2 OS=Macaca fascicularis OX=9541 GN=MAT2A PE=2 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|P31153|METK2_HUMAN (S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1)

HSP 1 Score: 574.704 bits (1480), Expect = 0.000e+0
Identity = 287/395 (72.66%), Postives = 329/395 (83.29%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R+ +K IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA +P++VHTIVIS QHDE + ++++R  L E V+K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Match: sp|P18298|METK2_RAT (S-adenosylmethionine synthase isoform type-2 OS=Rattus norvegicus OX=10116 GN=Mat2a PE=1 SV=1)

HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0
Identity = 286/395 (72.41%), Postives = 330/395 (83.54%), Query Frame = 1
Query:  130 MRSNPNSIHN-FNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  H  F EE TFLFTSESVGEGHPDKICDQ++DAVLDAHL QDP AKVACET +KTGMIL+ GEITS A ++YQ+V+R+ IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN KLAE RRN TLP+LRPD+KTQVTV Y    GA IP++VHTIVIS QHDE + ++++R  L E ++K V+P KYLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK GLCRRVLVQ+SYAIG++ PLSI +  YGT    + +LLEI+ +NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A1I8I605 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g3 PE=3 SV=1)

HSP 1 Score: 608.601 bits (1568), Expect = 0.000e+0
Identity = 295/380 (77.63%), Postives = 340/380 (89.47%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+MEHVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMEHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLRIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387          
BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A1I8HKQ4 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g1 PE=3 SV=1)

HSP 1 Score: 608.216 bits (1567), Expect = 0.000e+0
Identity = 295/380 (77.63%), Postives = 340/380 (89.47%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+MEHVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMEHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLHIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387          
BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267DP28 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008771g2 PE=3 SV=1)

HSP 1 Score: 607.06 bits (1564), Expect = 0.000e+0
Identity = 294/380 (77.37%), Postives = 340/380 (89.47%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QDP AKVACE F+KTGMIL+GGEITS A+V+YQRVIR TIKDIG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VHE RS++DIGAGDQGLMFGYATDET ECMPLT+VLAH LN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHDE++   QLRKD+M+HVVK V P   LD +TIYHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVK+GLCRRVLVQ+SYAIG++ PL+++++SYGTG   D +LL I+ +NFDLRPG I +DL+LR+PIYQKT+CYGHFGR EFTWEQ K LK+
Sbjct:    8 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDPNAKVACECFTKTGMILVGGEITSKAVVDYQRVIRGTIKDIGYDDSNKGFDYKTCNVLVALEEQSPDIAQGVHEARSEDDIGAGDQGLMFGYATDETVECMPLTIVLAHKLNAQLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDESVTQEQLRKDVMDHVVKAVCPSDMLDENTIYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKSGLCRRVLVQVSYAIGVSKPLAVYLNSYGTGKRSDEELLRIVEENFDLRPGCIVRDLELRKPIYQKTSCYGHFGRDEFTWEQAKPLKF 387          
BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267H2L8 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014959g3 PE=3 SV=1)

HSP 1 Score: 603.208 bits (1554), Expect = 0.000e+0
Identity = 290/380 (76.32%), Postives = 338/380 (88.95%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QD  AKVACE F+KTGMI++GGEI+S AIV+YQRVIR+TI+ IG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VH  R+D+DIGAGDQGLMFGYATDETEECMPLT+VLAHGLN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHD+NI   +LR D+MEHVVK V P++ LD  T+YHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PL+++++SYGTG+  D +LL I+  NFDLRPG I KDL+LR+PIYQKT+CYGHFG PEF+WE  K LK+
Sbjct:   10 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDANAKVACECFTKTGMIMVGGEISSTAIVDYQRVIRETIRQIGYDDSSKGFDYKTCNVLVALEEQSPDIAQGVHVARADDDIGAGDQGLMFGYATDETEECMPLTIVLAHGLNARLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDDNITQEKLRHDVMEHVVKAVCPKEMLDERTVYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQISYAIGVAKPLAVYLNSYGTGAKSDEELLRIVETNFDLRPGRIVKDLELRKPIYQKTSCYGHFGNPEFSWEMAKELKF 389          
BLAST of S-adenosylmethionine synthase vs. TrEMBL
Match: A0A267EMZ1 (S-adenosylmethionine synthase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014959g2 PE=3 SV=1)

HSP 1 Score: 602.053 bits (1551), Expect = 0.000e+0
Identity = 289/380 (76.05%), Postives = 338/380 (88.95%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDAVLDAHL QD  AKVACE F+KTGMI++GGEI+S AIV+YQRVIR+TI+ IG+D   KGFDYKTCN+L+A+E+Q+P+IAQ VH  R+D+DIGAGDQGLMFGYATDETEECMPLT+VLAHGLN +LA+CRR+ TLP+LRPDTKTQVTV YK  NGAC+PL++HTIV+STQHD+NI   +LR D+MEHVVK V P++ LD  T+YHLNPSGRFVIGGPQ DAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PL+++++SYGTG+  D +LL I+  NFDLRPG I KDL+LR+PIYQKT+CYGHFG PEF+WE  K L++
Sbjct:   10 KTFLFTSESVGEGHPDKICDQVSDAVLDAHLKQDANAKVACECFTKTGMIMVGGEISSTAIVDYQRVIRETIRQIGYDDSSKGFDYKTCNVLVALEEQSPDIAQGVHVARADDDIGAGDQGLMFGYATDETEECMPLTIVLAHGLNARLAQCRRDGTLPWLRPDTKTQVTVEYKDENGACVPLRIHTIVVSTQHDDNITQEKLRHDVMEHVVKAVCPKEMLDERTVYHLNPSGRFVIGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQISYAIGVAKPLAVYLNSYGTGAKSDEELLRIVETNFDLRPGRIVKDLELRKPIYQKTSCYGHFGNPEFSWEMAKELQF 389          
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2ab (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103044681])

HSP 1 Score: 566.229 bits (1458), Expect = 0.000e+0
Identity = 281/396 (70.96%), Postives = 329/396 (83.08%), Query Frame = 1
Query:  127 KMRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +M    N  HN   +E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R TI+ IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R+ ED+GAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN  LP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHDE+I ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DL LR+PIYQ+TA YGHFGR  F+WE PK L+Y
Sbjct:    5 EMNGEMNGFHNALIDEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRATVDYQKVVRDTIRHIGYDDSTKGFDYKTCNVLVALEQQSPDIAQGVHLDRNQEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGVLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDEDICLDEMRDALKEKVVKAVVPCVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAELCRRVLVQVSYAIGVAHPLSISIFHYGTSQKSERELLDIVRKNFDLRPGVIVRDLQLRKPIYQRTAAYGHFGRDSFSWEIPKKLQY 400          
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103041217])

HSP 1 Score: 562.762 bits (1449), Expect = 0.000e+0
Identity = 278/387 (71.83%), Postives = 333/387 (86.05%), Query Frame = 1
Query:  151 IHNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +++F+++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+ I + + ++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC+RVLVQ+SYAIG+A PLSI + +YG+    + +LL+I+N NFDLRPG I +DL L+RPIYQ TACYGHFGR EF WE PKTLK+
Sbjct:    4 LNDFHDDGSFMFTSESVGEGHPDKICDQISDAVLDAHLRQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHIDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDLISLEEQQRILKEKVIKAVVPAKYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVMAKLCKRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLQIVNKNFDLRPGVIVRDLKLKRPIYQDTACYGHFGRSEFPWEVPKTLKF 390          
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103041217])

HSP 1 Score: 554.673 bits (1428), Expect = 0.000e+0
Identity = 278/398 (69.85%), Postives = 333/398 (83.67%), Query Frame = 1
Query:  151 IHNFNEE-TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHI-----------EKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +++F+++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RR+ T+P+LRPD+KTQVTV YK  NGA IPL+VHT+VIS QHD+ I + + ++ L E V+K V+P KYLD  T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LC+RVLVQ+SYAIG+A PLSI + +YG+    + +LL+I+N NFDLRPG I            +DL L+RPIYQ TACYGHFGR EF WE PKTLK+
Sbjct:    4 LNDFHDDGSFMFTSESVGEGHPDKICDQISDAVLDAHLRQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHIDRHEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNSKMAELRRDGTIPWLRPDSKTQVTVHYKQENGAVIPLRVHTVVISVQHDDLISLEEQQRILKEKVIKAVVPAKYLDDKTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVMAKLCKRVLVQVSYAIGVAHPLSISLFTYGSSEKTEKELLQIVNKNFDLRPGVIVRVFQTWAVNNYRDLKLKRPIYQDTACYGHFGRSEFPWEVPKTLKF 401          
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2aa (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103039813])

HSP 1 Score: 553.903 bits (1426), Expect = 0.000e+0
Identity = 282/395 (71.39%), Postives = 328/395 (83.04%), Query Frame = 1
Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN    E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R  IK IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R++EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHT+V+S QHDE + ++++R  L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLC+RVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DLDL++PIYQ+TA YGHFGR  F WE PK LKY
Sbjct:    1 MNGQVNGFHNSIIEEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRACVDYQKVVRDAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTVVVSVQHDEVVCLDEMRDALKEKVVKAVVPSVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCKRVLVQVSYAIGVAHPLSISIFHYGTSQRSEKELLDIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRESFPWEVPKKLKY 395          
BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Match: mat2al (S-adenosylmethionine synthase [Source:NCBI gene;Acc:103022635])

HSP 1 Score: 499.204 bits (1284), Expect = 6.113e-176
Identity = 255/381 (66.93%), Postives = 306/381 (80.31%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQ-GDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVG+GH DK+CDQ+SDAVLDA+LSQDP AKVACE  +KTGMIL+ GE+TS A+V+ ++V+R T+KDIG+D   KGFDYKTCN+L+A++ Q  EI   V E R +EDIGAGDQG MFGYATDET+ECMPLT++LAH LN K+ E  +N    ++ PD+K+QVTV Y+   G   P++VHT+VIS QH  +I ++++RK+LME VVKTVIP KYLD  TIYHL PSG+F+IGGPQ        RKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKA LCRRVLVQ+SYAIGI+ PLSI V  YGT +  + +LLEI+  NFDLRPG I K+L L+RPIYQKTA YGHFGR EF WE+PK L +
Sbjct:   11 KTFLFTSESVGQGHSDKMCDQISDAVLDAYLSQDPDAKVACECVAKTGMILLCGEVTSKAVVDLEKVVRDTVKDIGYDDSSKGFDYKTCNVLVALQPQCEEITDCVFEGRDEEDIGAGDQGFMFGYATDETDECMPLTILLAHKLNHKMKELSKNGECAWILPDSKSQVTVEYRDNMGVMEPIRVHTVVISVQHTPDITLSEIRKNLMEKVVKTVIPAKYLDDRTIYHLLPSGKFLIGGPQVKKCRPYWRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAKLCRRVLVQISYAIGISHPLSISVFHYGTSTRDEDELLEIVQKNFDLRPGVIVKELGLKRPIYQKTASYGHFGREEFPWEKPKKLVF 391          
BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Match: SAM2 (S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon [Source:SGD;Acc:S000002910])

HSP 1 Score: 514.998 bits (1325), Expect = 0.000e+0
Identity = 252/380 (66.32%), Postives = 308/380 (81.05%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGHPDKICDQVSDA+LDA L QDP +KVACET +KTGMI++ GEIT+ A ++YQ+++R TIK IG+D   KGFDYKTCN+L+AIEQQ+P+IAQ +H E+S ED+GAGDQG+MFGYATDET E +PLT++LAH LNM +A+ RR+ +LP+LRPDTKTQVTV Y+  NG  +P ++ T+VIS QH + I    LR  L + +V+ VIP+  LD +T Y + PSGRFVIGGPQGDAGLTGRKIIVD YGG  + GGGAFSGKDYSKVDRS AYAARWVAKSLV AGLC+RV VQ SYAIGIA PLS+ VD+YGT +  D +++EII  NFDLRPG + K+LDL RPIY  TA YGHF   E++WE+PK L++
Sbjct:    5 KTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF 384          
BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Match: SAM1 (S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication [Source:SGD;Acc:S000004170])

HSP 1 Score: 514.612 bits (1324), Expect = 0.000e+0
Identity = 251/379 (66.23%), Postives = 306/379 (80.74%), Query Frame = 1
Query:  172 TFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            TFLFTSESVGEGHPDKICDQVSDA+LDA L++DP +KVACET +KTGMI++ GEIT+ A ++YQ+++R TIK IG+D   KGFDYKTCN+L+AIEQQ+P+IAQ VHEE+  EDIGAGDQG+MFGYATDET E +PLT++LAH LNM +A+ RR+ +L +LRPDTKTQVTV YK  +G  +P ++ T+V+S QH + I    LR  L   +++ VIP   LD +T Y + PSGRFVIGGPQGDAGLTGRKIIVD YGG  + GGGAFSGKDYSKVDRS AYAARWVAKSLV AGLC+RV VQ SYAIGIA PLS+ VD+YGT +  D ++++II+ NFDLRPG + K+LDL RPIY  TA YGHF   E+ WE+PKTLK+
Sbjct:    4 TFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF 382          
BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO37850 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7SEP5])

HSP 1 Score: 561.607 bits (1446), Expect = 0.000e+0
Identity = 284/406 (69.95%), Postives = 331/406 (81.53%), Query Frame = 1
Query:   91 NFT*TNAGFRVYKMRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +FT +N      K +  P    N    TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACET +KTGMIL+ GEITSNA+V+YQ V+RQ IKDIG+D  EKGFDYKTCN+L+A+EQQ+ +IA  VH  R +ED+GAGDQGLMFGYATDETEE MPLTVVLAH +N KLAE RR+ TLP+ RPD+KTQVTV YK  +G  IPL+VHTIVIS QHD  I +  LRK+LME +VKTV+P K+LD  TI+HL PSG FVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARW+AKSLV  GLC+RVLVQ+SYAIGIA PLS+ V SYGT    + +LL+I+ DNFDLRPG I K+LDL++P+YQK+  YGHF +P FTWE PK L+Y
Sbjct:    6 DFTFSNGAPPSKKYKMEPLDTQN---NTFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSNAVVDYQSVVRQCIKDIGYDDSEKGFDYKTCNVLVALEQQSVDIAHGVHVGREEEDVGAGDQGLMFGYATDETEELMPLTVVLAHKMNQKLAEYRRDGTLPWARPDSKTQVTVEYKFEHGRAIPLRVHTIVISVQHDPTITMENLRKELMEKIVKTVVPSKFLDEDTIFHLQPSGLFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWIAKSLVSEGLCKRVLVQISYAIGIAQPLSVTVFSYGTSKKSEDELLKIVRDNFDLRPGKIVKELDLKKPVYQKSCVYGHF-KPGFTWETPKPLQY 407          
BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO37825 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7SEP6])

HSP 1 Score: 555.444 bits (1430), Expect = 0.000e+0
Identity = 280/391 (71.61%), Postives = 329/391 (84.14%), Query Frame = 1
Query:  136 SNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            + P++++N    TFLFTSESVGEGHPDK+CDQ+SDA+LDAHL QDP AKVACE+ +KTGMI++ GEITS A V+YQ+V+R TIK IG+D   KGFDYKTC +L AIEQQ+P+IAQ VH  RSDED+GAGDQGLMFGYATDET+E MPLTVVLAHGLN +LA+CRRN +LP++RPD+KTQVTV YK   G  +PL+VHTIVIS QHD NI ++ +RK+LM++VVK V+PEKY+D  T+YH+ PSG FVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD SKVDRS AYAARW+AKSLV A LC RVLVQLSYAIG+A PLSI V +YGTG  P+ +LLE+I  NFDLRPG I +DLDL++PIYQ T  YGHF +P F WE PK LKY
Sbjct:    2 NTPDTLNN----TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACESVAKTGMIVVCGEITSLANVDYQKVVRDTIKQIGYDDSSKGFDYKTCTVLQAIEQQSPDIAQGVHIGRSDEDLGAGDQGLMFGYATDETDELMPLTVVLAHGLNKRLADCRRNGSLPWVRPDSKTQVTVEYKFQGGKAVPLRVHTIVISVQHDPNIELDVMRKELMDYVVKEVVPEKYIDNDTVYHMQPSGSFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAKLCHRVLVQLSYAIGVAEPLSISVFTYGTGYRPEEELLEVIKHNFDLRPGVIVRDLDLKKPIYQSTCLYGHF-KPGFPWEVPKPLKY 387          
BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO45117 (S-adenosylmethionine synthase [Source:UniProtKB/TrEMBL;Acc:A7RTZ9])

HSP 1 Score: 509.99 bits (1312), Expect = 4.402e-180
Identity = 260/379 (68.60%), Postives = 310/379 (81.79%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLK 1305
            + FLFTSESV EGH DK+CDQ+SDAVLDAHL QDP AKVACET +KTG++L+ GEITSNA V+YQ V+R TI+DIG++    GFDYKTC++L+AI++Q  EIAQ+VH  R D++IGAGDQGLMFGYATDETEE MPLT VLAH L  +LAECR+   LP+L PD KTQVTV Y+   GACIP +VHT++ISTQH  ++ I ++R  L E ++  VIPEKYLD  TI+HL PSG+F+ GGP GDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRSGAYA RW+AKSLV AGLCRRVLVQ++YAIGIA PLSI V SYG+G+  D QLL +I DNFDLRPG I +DL+L RPIY+ T+ +GHF +P F WE+PK LK
Sbjct:   50 DNFLFTSESVNEGHSDKMCDQISDAVLDAHLEQDPYAKVACETATKTGLVLLFGEITSNARVDYQAVVRNTIRDIGYNDSSTGFDYKTCSVLLAIQEQVAEIAQTVHLNRRDDEIGAGDQGLMFGYATDETEELMPLTTVLAHKLCARLAECRKGKILPWLLPDGKTQVTVDYRLERGACIPERVHTVLISTQHTPDVGIEEIRHHLKETIINHVIPEKYLDDKTIFHLLPSGQFIDGGPLGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDVTKVDRSGAYACRWIAKSLVAAGLCRRVLVQVAYAIGIAEPLSISVFSYGSGNYTDKQLLGVIKDNFDLRPGVIIRDLNLLRPIYKATSTFGHF-KPGFPWEEPKKLK 427          
BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Match: EDO26870 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAU6])

HSP 1 Score: 207.994 bits (528), Expect = 4.552e-65
Identity = 117/212 (55.19%), Postives = 154/212 (72.64%), Query Frame = 1
Query:  451 IEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYA 1086
            I +Q+ +I Q V   +  ED GAGDQGLMFGYAT+ET+  MP  V  AH L  + +E RRN TLP+LRPD K+QVT+ ++  +      KV  +V+STQHD +I ++ LR+ ++E+++K V+P ++L   T+YH+NP+G FVIGGP GDAGLTGRKIIVDTYGG   HGGGAFSGKD SKVDRS AY  R+VAK++V A L  +  +Q+SYA
Sbjct:    1 IGKQSVDINQGVDRAKP-EDQGAGDQGLMFGYATNETDSLMPAPVYYAHRLVERQSELRRNGTLPWLRPDAKSQVTINWEGDS-----PKVDAVVLSTQHDPSISLDDLREAVLENIIKPVLPAEWLHEGTLYHINPTGNFVIGGPVGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYIGRYVAKNIVAAELADKCEIQVSYA 206          
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat2ab (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101160913])

HSP 1 Score: 572.007 bits (1473), Expect = 0.000e+0
Identity = 284/395 (71.90%), Postives = 328/395 (83.04%), Query Frame = 1
Query:  130 MRSNPNSIHN--FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            M    N  HN    E+ FLFTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET +KTGMIL+ GE+TS A V+YQ+V+R TI+ IG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +RS+E+IGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN TLP+LRPD+KTQVTV Y+   GA +P++VHTIV+S QHDE+I + ++R  L E V+K V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI +  YGT    + +LL+I+  NFDLRPG I +DLDL++P YQKTA YGHFGR  F WE PK LKY
Sbjct:    2 MNGQMNGFHNSLIEEDCFLFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVAKTGMILLAGEVTSRATVDYQKVVRDTIRQIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHIDRSEEEIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTLPWLRPDSKTQVTVQYRQDRGAMLPVRVHTIVVSVQHDEDICLEEMRDALKEKVIKAVVPCVYLDDDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAHPLSISIFHYGTSKKSERELLDIVRKNFDLRPGVIVRDLDLKKPFYQKTAAYGHFGRDSFPWEVPKKLKY 396          
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: ENSORLT00000011581.2 (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101171015])

HSP 1 Score: 562.377 bits (1448), Expect = 0.000e+0
Identity = 278/391 (71.10%), Postives = 329/391 (84.14%), Query Frame = 1
Query:  145 NSIHN---FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            N  H+    +++ FLFTSESVGEGHPDKICDQ+SDAVLDAHLSQDP AKVACET +KTGMIL+ GEITS A V+YQ+V+R  I+DIG+D   KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +ED+GAGDQGLMFGYATDET+ECMPLT+VLAH LN K+AE RR+ TLP+LRPD+KTQVTV YK   GA +PL+VHTIVIS QHDE + + ++R+ L E VVK V+P  YLD  TIYHL PSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLVK+ LCRRVLVQ+SYAIG++ PLS+ +  YGT    + +LL+I+  NFDLRPG I ++LDL++PIYQ+TA YGHFGR  F+WE PK LKY
Sbjct:    2 NGFHHDLLHDKDCFLFTSESVGEGHPDKICDQISDAVLDAHLSQDPDAKVACETVAKTGMILLAGEITSRAKVDYQKVVRDAIRDIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRKEEDVGAGDQGLMFGYATDETDECMPLTIVLAHKLNAKMAELRRDGTLPWLRPDSKTQVTVQYKQDRGAVVPLRVHTIVISVQHDECVCLEEMRRCLKEQVVKAVVPSGYLDDETIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKSNLCRRVLVQVSYAIGVSHPLSVSIFHYGTSQRSERELLDIVMKNFDLRPGVIVRELDLKKPIYQRTAAYGHFGRDVFSWEMPKKLKY 392          
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat1a (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101160342])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 276/383 (72.06%), Postives = 327/383 (85.38%), Query Frame = 1
Query:  160 FNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
             ++ +F+FTSESVGEGHPDKICDQ+SDAVLDAHL QDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R TIK IG+D+ +KGFDYKTCN+L+A+EQQ+P+IAQ VH +R +EDIGAGDQGLMFGYATDETEECMPLT+VLAH LN K+AE RRN T+P+LRPD+KTQVTV Y+  +GA IP +VHTIVIS QHD+ + + + +K L E V+K V+P KYLD  TI HL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKA LCRRVLVQ+SYAIG+A PLSI + +YG+    +S+LL+I+N NFDLRPG I +DL L+RPIYQ+TA YGHFGR EF+WE PK L +
Sbjct:    5 LDDNSFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPDAKVACETVCKTGMVLLCGEITSRANVDYQKVVRDTIKHIGYDNSDKGFDYKTCNVLVALEQQSPDIAQGVHVDRQEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKMAELRRNGTVPWLRPDSKTQVTVHYEQKDGAVIPKRVHTIVISVQHDDGVTLEEQQKALKEKVIKAVVPAKYLDDKTICHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAKLCRRVLVQVSYAIGVAQPLSISLFTYGSSKKTESELLKIVNKNFDLRPGVIVRDLQLKRPIYQQTAAYGHFGRSEFSWEVPKKLVF 387          
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: ENSORLT00000016106.2 (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101159865])

HSP 1 Score: 553.518 bits (1425), Expect = 0.000e+0
Identity = 270/382 (70.68%), Postives = 324/382 (84.82%), Query Frame = 1
Query:  163 NEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +E  FLFTSESVGEGHPDK+CDQ+SDAVLDAHLSQDP AKVACET  KTGM+L+ GEITS A V+YQ+V+R  IK IG+DS  KG DYKTCN+L+A+E+Q+P+IAQ VH +R + +IGAGDQGLMFGYATDETEECMPLT+VLAH LN ++AE RRN T+P+LRPD+KTQVTV Y   +GA IP ++HT+VIS QHD+++ + + R  LME V++ VIP KYLD +T+YHL PSGRFVIGGPQGDAG+TGRKIIVDTYGGWGAHGGGAFSGKDY+KVDRS AYAARWVAKSLV A LCRRVLVQ++YAIG+A PLSI + ++G+    + +LL+I+  NFDLRPG I +DLDL+RPIYQKTACYGHFGR EF WE PK L++
Sbjct:   16 DEGAFLFTSESVGEGHPDKMCDQISDAVLDAHLSQDPDAKVACETVCKTGMVLLCGEITSRASVDYQKVVRDVIKHIGYDSSSKGLDYKTCNVLVALEEQSPDIAQGVHVDRMESEIGAGDQGLMFGYATDETEECMPLTIVLAHKLNARMAELRRNGTVPWLRPDSKTQVTVHYSQESGAVIPERIHTVVISVQHDDHVSLEEQRSVLMEKVIRAVIPAKYLDENTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVNARLCRRVLVQVAYAIGVAHPLSISLFTFGSSQKSEKELLQIVYRNFDLRPGVIVRDLDLKRPIYQKTACYGHFGRKEFPWEVPKNLEF 397          
BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Match: mat2al (S-adenosylmethionine synthase [Source:NCBI gene;Acc:101170772])

HSP 1 Score: 525.013 bits (1351), Expect = 0.000e+0
Identity = 264/380 (69.47%), Postives = 310/380 (81.58%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +TFLFTSESVGEGH DK+CDQ+SDAVLDA+LSQDP +KVACE  +KTGMIL+ GE+TS A V+ Q V+R TIK IG+DS  KGFDYKTCN+L+A+E Q  EI+  V E R+ EDIGAGDQGLMFGYATDETEECMPLT++LAH LN K+ E  RN   P++ PD K+QVTV Y+   GA  PL+VHT+VIS QH  +I + ++R +LME VVK VIP KYLD  T+YHL PSG+F++GGPQGDAGLTGRKIIVDTYGGWG HGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRR LVQ+SY+I ++ PLSI V  YGT S  + +LL+I+ DNFDLRPG I  +L L+RPIYQ TACYGHFGR EF WE+PK L +
Sbjct:   11 KTFLFTSESVGEGHSDKMCDQISDAVLDAYLSQDPDSKVACECVAKTGMILLVGEVTSRAKVDLQAVVRNTIKKIGYDSSSKGFDYKTCNVLVALEPQAQEISDCVFEGRNQEDIGAGDQGLMFGYATDETEECMPLTILLAHKLNHKMKELSRNGDCPWILPDCKSQVTVEYRDDAGAMEPLRVHTVVISVQHSPDISLEEIRHNLMEKVVKAVIPAKYLDDQTVYHLLPSGKFLLGGPQGDAGLTGRKIIVDTYGGWGGHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRALVQISYSIAVSHPLSITVFHYGTSSRDEDELLQIVKDNFDLRPGVIVTELGLKRPIYQATACYGHFGREEFPWEKPKPLVF 390          
BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000053202.1 (SMESG000053202.1)

HSP 1 Score: 786.563 bits (2030), Expect = 0.000e+0
Identity = 393/393 (100.00%), Postives = 393/393 (100.00%), Query Frame = 1
Query:  130 MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY
Sbjct:    1 MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 393          
BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000027587.1 (SMESG000027587.1)

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 301/382 (78.80%), Postives = 344/382 (90.05%), Query Frame = 1
Query:  163 NEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            +  TFLFTSESVGEGHPDKICDQ+SDA+LDAHL QDP AKVACETF+KTGMIL+GGEI+S A+V+YQ+V+R+TIK+IG+D CEKGFDYKTCN+L+AIE+Q+P+IAQ VH ER  ++IGAGDQGLMFGYATDET ECMPLTVVLAH LN +L+ECRRN TLP+LRPDTKTQVTV YKS NGACIPL+VHT+VISTQHDE I    L++ L++ ++K VIPE YLD  TIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD+SKVDRS AYAARWVAKSLVKAGLCRRVLVQ+SYAIG+A PLSI+VDSYGT S  D++LL I+ DNFDLRPGHI K+L+LR PIY+KTACYGHFGR EFTWE+PK LK+
Sbjct:    5 SSNTFLFTSESVGEGHPDKICDQISDAILDAHLKQDPNAKVACETFAKTGMILVGGEISSKAVVDYQKVVRETIKEIGYDHCEKGFDYKTCNVLLAIEEQSPDIAQGVHLERDFDNIGAGDQGLMFGYATDETAECMPLTVVLAHALNKRLSECRRNGTLPWLRPDTKTQVTVEYKSDNGACIPLRVHTVVISTQHDETISHQHLQQCLIKEIIKKVIPEHYLDEETIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAHPLSIYVDSYGTSSHSDAELLRIVVDNFDLRPGHIVKELNLRHPIYKKTACYGHFGREEFTWEKPKKLKF 386          
BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Match: SMESG000013953.1 (SMESG000013953.1)

HSP 1 Score: 567.385 bits (1461), Expect = 0.000e+0
Identity = 277/380 (72.89%), Postives = 324/380 (85.26%), Query Frame = 1
Query:  169 ETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKAKVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYKTCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPLTVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHTIVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYXXXXXXXXXXXXXKDYSKVDRSGAYAARWVAKSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDNFDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY 1308
            + FLFTSESVGEGHPDKICDQ+SDA+LDAHL QDP AKVACE+F+KTGM+L+GGEITS+A+VNY  ++R TIK IGFDS EKG DY+TCN+L+AIEQQ+P+IAQ V+  RS++ IGAGDQGLMFGYATDETEECMP+T++LAH LN +LA CRRN+ L +LRPDTKTQVT+ YK+ +G  +PL VHTIVIS QHDE + +  ++ DLM+HV+  VI  K L +STIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD +KVDRS AYAARWVAKSLVK GLC+RVLVQ SYAIGIAAPLSIFV SY + +  D++LL I+N NFDLRPG I +DL LR PI++KTA YGHFGR EF WE PK L +
Sbjct:    5 DIFLFTSESVGEGHPDKICDQISDAILDAHLKQDPYAKVACESFTKTGMVLVGGEITSHAVVNYSDIVRNTIKRIGFDSSEKGLDYRTCNVLVAIEQQSPDIAQGVYVNRSEDSIGAGDQGLMFGYATDETEECMPMTLILAHKLNQRLAYCRRNDILGWLRPDTKTQVTIAYKNKDGGLLPLYVHTIVISAQHDEEVTLENIKSDLMKHVISNVIDSKMLTSSTIYHLNPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDATKVDRSAAYAARWVAKSLVKNGLCKRVLVQFSYAIGIAAPLSIFVYSYNSSTKTDNELLAIVNQNFDLRPGAIIRDLKLREPIFEKTASYGHFGRNEFLWENPKKLHF 384          
The following BLAST results are available for this feature:
BLAST of S-adenosylmethionine synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
MAT2A0.000e+072.66methionine adenosyltransferase 2A [Source:HGNC Sym... [more]
MAT1A0.000e+070.91methionine adenosyltransferase 1A [Source:HGNC Sym... [more]
MAT2A1.431e-14972.39methionine adenosyltransferase 2A [Source:HGNC Sym... [more]
MAT1A1.154e-7058.06methionine adenosyltransferase 1A [Source:HGNC Sym... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sams-30.000e+068.06Probable S-adenosylmethionine synthase 3 [Source:... [more]
sams-40.000e+068.68Probable S-adenosylmethionine synthase 4 [Source:... [more]
sams-40.000e+068.68Probable S-adenosylmethionine synthase 4 [Source:... [more]
sams-50.000e+067.54Probable S-adenosylmethionine synthase 5 [Source:... [more]
sams-50.000e+067.54Probable S-adenosylmethionine synthase 5 [Source:... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sam-S0.000e+068.46gene:FBgn0005278 transcript:FBtr0089430[more]
Sam-S0.000e+068.46gene:FBgn0005278 transcript:FBtr0089433[more]
Sam-S0.000e+068.46gene:FBgn0005278 transcript:FBtr0089432[more]
Sam-S0.000e+068.46gene:FBgn0005278 transcript:FBtr0089429[more]
Sam-S0.000e+068.46gene:FBgn0005278 transcript:FBtr0089434[more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mat2aa0.000e+071.39methionine adenosyltransferase II, alpha a [Source... [more]
mat1a0.000e+071.83methionine adenosyltransferase I, alpha [Source:ZF... [more]
mat1a0.000e+071.83methionine adenosyltransferase I, alpha [Source:ZF... [more]
mat2al0.000e+068.68methionine adenosyltransferase II, alpha-like [Sou... [more]
mat2al0.000e+068.68methionine adenosyltransferase II, alpha-like [Sou... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mat1a0.000e+073.35methionine adenosyltransferase I, alpha [Source:NC... [more]
use10.000e+071.03unconventional SNARE in the ER 1 homolog [Source:X... [more]
use10.000e+071.03unconventional SNARE in the ER 1 homolog [Source:X... [more]
mat1a0.000e+072.73methionine adenosyltransferase I, alpha [Source:NC... [more]
use10.000e+068.21unconventional SNARE in the ER 1 homolog [Source:X... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Mat2a0.000e+072.66methionine adenosyltransferase II, alpha [Source:M... [more]
Mat2a0.000e+072.66methionine adenosyltransferase II, alpha [Source:M... [more]
Mat1a0.000e+072.02methionine adenosyltransferase I, alpha [Source:MG... [more]
Mat1a0.000e+072.02methionine adenosyltransferase I, alpha [Source:MG... [more]
Mat2a0.000e+072.53methionine adenosyltransferase II, alpha [Source:M... [more]
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BLAST of S-adenosylmethionine synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5R5H1|METK2_PONAB0.000e+072.66S-adenosylmethionine synthase isoform type-2 OS=Po... [more]
sp|Q3THS6|METK2_MOUSE0.000e+072.66S-adenosylmethionine synthase isoform type-2 OS=Mu... [more]
sp|Q4R924|METK2_MACFA0.000e+072.66S-adenosylmethionine synthase isoform type-2 OS=Ma... [more]
sp|P31153|METK2_HUMAN0.000e+072.66S-adenosylmethionine synthase isoform type-2 OS=Ho... [more]
sp|P18298|METK2_RAT0.000e+072.41S-adenosylmethionine synthase isoform type-2 OS=Ra... [more]
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BLAST of S-adenosylmethionine synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8I6050.000e+077.63S-adenosylmethionine synthase OS=Macrostomum ligna... [more]
A0A1I8HKQ40.000e+077.63S-adenosylmethionine synthase OS=Macrostomum ligna... [more]
A0A267DP280.000e+077.37S-adenosylmethionine synthase OS=Macrostomum ligna... [more]
A0A267H2L80.000e+076.32S-adenosylmethionine synthase OS=Macrostomum ligna... [more]
A0A267EMZ10.000e+076.05S-adenosylmethionine synthase OS=Macrostomum ligna... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mat2ab0.000e+070.96S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat1a0.000e+071.83S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat1a0.000e+069.85S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat2aa0.000e+071.39S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat2al6.113e-17666.93S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of S-adenosylmethionine synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
SAM20.000e+066.32S-adenosylmethionine synthetase; catalyzes transfe... [more]
SAM10.000e+066.23S-adenosylmethionine synthetase; catalyzes transfe... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO378500.000e+069.95S-adenosylmethionine synthase [Source:UniProtKB/T... [more]
EDO378250.000e+071.61S-adenosylmethionine synthase [Source:UniProtKB/T... [more]
EDO451174.402e-18068.60S-adenosylmethionine synthase [Source:UniProtKB/T... [more]
EDO268704.552e-6555.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of S-adenosylmethionine synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mat2ab0.000e+071.90S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
ENSORLT00000011581.20.000e+071.10S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat1a0.000e+072.06S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
ENSORLT00000016106.20.000e+070.68S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
mat2al0.000e+069.47S-adenosylmethionine synthase [Source:NCBI gene;Ac... [more]
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BLAST of S-adenosylmethionine synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000053202.10.000e+0100.00SMESG000053202.1[more]
SMESG000027587.10.000e+078.80SMESG000027587.1[more]
SMESG000013953.10.000e+072.89SMESG000013953.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021445 ID=SMED30021445|Name=S-adenosylmethionine synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1392bp
CATTCATGTGTTGAATATTCATAATCATTCAAAAAAGTTATCGCCTGGAC
TATGACTTATGAAAGTAGCATATGTAGTAAAATTACTTAAAACTTTACTT
GAACTAATGCAGGTTTTAGAGTATACAAAATGAGATCGAATCCAAACTCA
ATTCACAATTTTAATGAAGAAACATTTCTGTTTACTTCAGAATCTGTAGG
CGAAGGACATCCAGATAAAATATGTGACCAAGTTAGTGACGCCGTTCTTG
ATGCCCACCTTTCTCAGGACCCAAAAGCTAAAGTGGCTTGTGAGACGTTT
TCTAAAACCGGAATGATCCTAATCGGAGGAGAAATAACTTCTAATGCCAT
TGTCAATTATCAAAGAGTCATAAGACAAACAATTAAAGACATTGGTTTTG
ACAGTTGCGAGAAGGGTTTCGATTATAAAACATGCAATTTGTTGATAGCG
ATAGAGCAACAAAATCCGGAAATCGCACAAAGCGTTCATGAAGAAAGATC
GGATGAGGATATTGGTGCAGGCGATCAAGGTCTAATGTTTGGTTATGCAA
CCGATGAAACGGAAGAATGTATGCCACTGACAGTTGTATTAGCTCATGGA
TTAAATATGAAACTAGCTGAATGTCGAAGAAACAATACTCTACCATATTT
ACGACCTGATACAAAAACCCAGGTAACTGTCCTGTATAAGTCAGTTAATG
GGGCATGTATACCTTTAAAAGTTCATACCATTGTAATTTCAACTCAACAC
GATGAAAATATACACATAAATCAACTTCGTAAAGATTTAATGGAGCATGT
TGTAAAAACCGTAATTCCTGAAAAGTATTTAGACGCTAGTACAATATACC
ATTTAAATCCATCAGGGAGATTTGTAATTGGTGGGCCACAAGGTGACGCA
GGTTTAACTGGTAGAAAAATTATTGTGGATACTTATGGTGGTTGGGGAGC
TCATGGTGGAGGAGCCTTTTCTGGAAAGGACTATTCAAAAGTCGATCGTA
GCGGAGCATACGCCGCTAGATGGGTAGCAAAGTCATTAGTCAAAGCAGGA
CTTTGTCGAAGGGTACTTGTTCAACTGTCATATGCCATTGGTATTGCTGC
TCCTTTGTCAATTTTTGTCGATAGCTATGGAACAGGTTCCATACCAGATT
CACAATTGTTAGAGATTATAAATGATAATTTTGACCTTCGACCTGGCCAC
ATAGAAAAAGACTTGGATCTTCGAAGACCAATTTATCAGAAGACTGCCTG
CTATGGACATTTTGGAAGACCAGAGTTTACATGGGAACAACCAAAAACAT
TGAAATATTAACATTTGTTCAGCTAATTTAAATATAATTAATAATGTGTA
ATTTATTGATATATAAACATGAGATACACAAAATAAGATGAT
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protein sequence of SMED30021445-orf-1

>SMED30021445-orf-1 ID=SMED30021445-orf-1|Name=SMED30021445-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=394bp
MRSNPNSIHNFNEETFLFTSESVGEGHPDKICDQVSDAVLDAHLSQDPKA
KVACETFSKTGMILIGGEITSNAIVNYQRVIRQTIKDIGFDSCEKGFDYK
TCNLLIAIEQQNPEIAQSVHEERSDEDIGAGDQGLMFGYATDETEECMPL
TVVLAHGLNMKLAECRRNNTLPYLRPDTKTQVTVLYKSVNGACIPLKVHT
IVISTQHDENIHINQLRKDLMEHVVKTVIPEKYLDASTIYHLNPSGRFVI
GGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSGAYAARWVA
KSLVKAGLCRRVLVQLSYAIGIAAPLSIFVDSYGTGSIPDSQLLEIINDN
FDLRPGHIEKDLDLRRPIYQKTACYGHFGRPEFTWEQPKTLKY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0002075pigment cell
PLANA:0003108gastrodermal cell
Vocabulary: INTERPRO
TermDefinition
IPR022630S-AdoMet_synt_C
IPR002133S-AdoMet_synthetase
IPR022628S-AdoMet_synt_N
IPR022629S-AdoMet_synt_central
IPR022631ADOMET_SYNTHASE_CS
IPR022636S-AdoMet_synthetase_sfam
Vocabulary: biological process
TermDefinition
GO:0006556S-adenosylmethionine biosynthetic process
GO:0006730one-carbon metabolic process
Vocabulary: molecular function
TermDefinition
GO:0004478methionine adenosyltransferase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0016740transferase activity
GO:0046872metal ion binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR022629S-adenosylmethionine synthetase, central domainPFAMPF02772S-AdoMet_synt_Mcoord: 128..248
e-value: 1.3E-45
score: 154.5
IPR022628S-adenosylmethionine synthetase, N-terminalPFAMPF00438S-AdoMet_synt_Ncoord: 16..113
e-value: 2.8E-40
score: 137.0
IPR022630S-adenosylmethionine synthetase, C-terminalPFAMPF02773S-AdoMet_synt_Ccoord: 250..387
e-value: 1.9E-68
score: 228.7
NoneNo IPR availableGENE3DG3DSA:3.30.300.10coord: 17..252
e-value: 2.1E-172
score: 575.2
NoneNo IPR availableGENE3DG3DSA:3.30.300.10coord: 127..386
e-value: 2.1E-172
score: 575.2
NoneNo IPR availableGENE3DG3DSA:3.30.300.10coord: 23..289
e-value: 2.1E-172
score: 575.2
NoneNo IPR availablePANTHERPTHR11964:SF12S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2coord: 11..393
NoneNo IPR availableCDDcd18079S-AdoMet_syntcoord: 17..389
e-value: 0.0
score: 691.067
IPR002133S-adenosylmethionine synthetasePIRSFPIRSF000497MATcoord: 10..393
e-value: 2.3E-165
score: 547.8
IPR002133S-adenosylmethionine synthetaseTIGRFAMTIGR01034TIGR01034coord: 17..392
e-value: 1.7E-178
score: 591.3
IPR002133S-adenosylmethionine synthetasePANTHERPTHR11964S-ADENOSYLMETHIONINE SYNTHETASEcoord: 11..393
IPR022631S-adenosylmethionine synthetase, conserved sitePROSITEPS00376ADOMET_SYNTHASE_1coord: 129..139
IPR022631S-adenosylmethionine synthetase, conserved sitePROSITEPS00377ADOMET_SYNTHASE_2coord: 276..284
IPR022636S-adenosylmethionine synthetase superfamilySUPERFAMILYSSF55973S-adenosylmethionine synthetasecoord: 125..249
IPR022636S-adenosylmethionine synthetase superfamilySUPERFAMILYSSF55973S-adenosylmethionine synthetasecoord: 15..122
IPR022636S-adenosylmethionine synthetase superfamilySUPERFAMILYSSF55973S-adenosylmethionine synthetasecoord: 250..392