Arginine N-methyltransferase 2

Overview
NameArginine N-methyltransferase 2
Smed IDSMED30021327
Length (bp)1300
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Arginine N-methyltransferase 2 (SMED30021327) t-SNE clustered cells

Violin plots show distribution of expression levels for Arginine N-methyltransferase 2 (SMED30021327) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Arginine N-methyltransferase 2 (SMED30021327) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Arginine N-methyltransferase 2 (SMED30021327) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021327

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30021327h1SMcG0015239 SmedASXL_016181SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30021327h1SMcG0015239 SmedASXL_016181SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Human
Match: GAMT (guanidinoacetate N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4136])

HSP 1 Score: 62.3882 bits (150), Expect = 1.778e-10
Identity = 49/144 (34.03%), Postives = 63/144 (43.75%), Query Frame = 1 
Query:  496 GLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            G  VM  WE   M   AA                      K  RVL VGFGM I  + +Q     EH+IIE +  V+Q L    WA +   K+  L G W+DV  TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   38 GKPVMERWETPYMHALAA------------------AASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRD--WAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEE---TWHTHQFNFIKNHAFR 158
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Human
Match: GAMT (guanidinoacetate N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4136])

HSP 1 Score: 61.6178 bits (148), Expect = 5.045e-10
Identity = 47/133 (35.34%), Postives = 59/133 (44.36%), Query Frame = 1 
Query:  496 GLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEH 885
            G  VM  WE   M   AA                      K  RVL VGFGM I  + +Q     EH+IIE +  V+Q L    WA +   K+  L G W+DV  TL D  FDGI +DTY   ++    +H H
Sbjct:   38 GKPVMERWETPYMHALAA------------------AASSKGGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRD--WAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEE---TWHTH 147
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Human
Match: GAMT (guanidinoacetate N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4136])

HSP 1 Score: 60.4622 bits (145), Expect = 6.914e-10
Identity = 40/101 (39.60%), Postives = 54/101 (53.47%), Query Frame = 1 
Query:  625 RVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            RVL VGFGM I  + +Q     EH+IIE +  V+Q L    WA +   K+  L G W+DV  TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   40 RVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRD--WAPRQTHKVIPLKGLWEDVAPTLPDGHFDGILYDTYPLSEE---TWHTHQFNFIKNHAFR 135
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Zebrafish
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:796865])

HSP 1 Score: 63.1586 bits (152), Expect = 6.339e-11
Identity = 38/102 (37.25%), Postives = 53/102 (51.96%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            K  RVL +GFGM I  T ++S    EH+IIE +  V+Q L     +    V  L G W++V  TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   58 KGGRVLEIGFGMAIAATKVESFPIEEHWIIECNDGVFQRLQEWAKSQPHKVVPLKGLWEEVAPTLPDNHFDGILYDTYPLSEE---TWHTHQFNFIKAHAHR 156
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Zebrafish
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:796865])

HSP 1 Score: 63.1586 bits (152), Expect = 6.339e-11
Identity = 38/102 (37.25%), Postives = 53/102 (51.96%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            K  RVL +GFGM I  T ++S    EH+IIE +  V+Q L     +    V  L G W++V  TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   58 KGGRVLEIGFGMAIAATKVESFPIEEHWIIECNDGVFQRLQEWAKSQPHKVVPLKGLWEEVAPTLPDNHFDGILYDTYPLSEE---TWHTHQFNFIKAHAHR 156
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Xenopus
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:394491])

HSP 1 Score: 67.781 bits (164), Expect = 2.407e-12
Identity = 43/110 (39.09%), Postives = 61/110 (55.45%), Query Frame = 1 
Query:  598 SSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            +S    K  RVL +GFGM I  T ++ ++  EH+IIE +  V++ L    WA+K   KI  L G W+DVV TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   50 ASVAASKGGRVLEIGFGMAIAATKLEEYNIEEHWIIECNDGVFKRLQE--WATKQPHKIVPLKGLWEDVVPTLPDGHFDGILYDTYPLSEE---TWHTHQFNFIKGHACR 154
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Xenopus
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:394491])

HSP 1 Score: 67.3958 bits (163), Expect = 2.886e-12
Identity = 43/110 (39.09%), Postives = 61/110 (55.45%), Query Frame = 1 
Query:  598 SSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            +S    K  RVL +GFGM I  T ++ ++  EH+IIE +  V++ L    WA+K   KI  L G W+DVV TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   50 ASVAASKGGRVLEIGFGMAIAATKLEEYNIEEHWIIECNDGVFKRLQE--WATKQPHKIVPLKGLWEDVVPTLPDGHFDGILYDTYPLSEE---TWHTHQFNFIKGHACR 154
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Mouse
Match: Gamt (guanidinoacetate methyltransferase [Source:MGI Symbol;Acc:MGI:1098221])

HSP 1 Score: 58.9214 bits (141), Expect = 2.110e-9
Identity = 39/104 (37.50%), Postives = 55/104 (52.88%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            +  RVL VGFGM I  + +Q     EH+IIE +  V+Q L    WA +   K+  L G W++V  TL D  FDGI +DTY   ++    +H H  + +  H  R
Sbjct:   60 RGGRVLEVGFGMAIAASRVQQAPIEEHWIIECNDGVFQRLQD--WALRQPHKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEE---AWHTHQFNFIKNHAFR 158
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Mouse
Match: Gamt (guanidinoacetate methyltransferase [Source:MGI Symbol;Acc:MGI:1098221])

HSP 1 Score: 58.5362 bits (140), Expect = 3.087e-9
Identity = 35/85 (41.18%), Postives = 48/85 (56.47%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTL-DVTFDGIFFDTYAEDDQ 861
            +  RVL VGFGM I  + +Q     EH+IIE +  V+Q L    WA +   K+  L G W++V  TL D  FDGI +DTY   ++
Sbjct:   60 RGGRVLEVGFGMAIAASRVQQAPIEEHWIIECNDGVFQRLQD--WALRQPHKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEE 142
[Close]
BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Match: sp|Q10170|RMT2_SCHPO (Protein arginine N-methyltransferase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rmt2 PE=3 SV=2)

HSP 1 Score: 193.741 bits (491), Expect = 1.243e-56
Identity = 120/358 (33.52%), Postives = 187/358 (52.23%), Query Frame = 1 
Query:  112 VKLFQAIEEKDIEQIKSLIELDDCDITYQ-DKNTGVSPLMIAAG-------VGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAH----MNRHQECIDALLHHATISEMLLGRALLNKKRTLNSNYLSKEVSYT-----SDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL--DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHT-GRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFD 1125
            + L +A ++ D+++I++L+  D   +T   D  +G + L   A        V  +E+ K +L  G  WN +DR  +  G  A     +  ++  +DA +    +  +L  + L N++   N  YL   +SYT     S  L+DS+  AVMM WE+ +M + A  I             P+     K  RVLNVGFG+GI+DT +Q  +P+ H IIE HP V +H+  +GW  +  V +    W++ ++ +     FDGI++D +AE  +DLR+F + +  LL P T  ++SF+NGL  DN  F+ V  ++  ++L   GL C YES+ V   D E WKG K RYW    Y+LP   FD
Sbjct:   19 LSLLEASKQLDLKKIQNLV--DQGAVTSAIDIESGKNALHFIASYAEKETEVQAIEVTKWILSNGGVWNGIDRANETPGCIARRRNLLRLYETIVDAGVRSELLLSLLERKELTNEQLDTNEKYLQSALSYTQPTEDSSSLLDSDANAVMMSWERKIMHRSAEIIA------------PT-----KGRRVLNVGFGLGIIDTFLQEKEPSLHVIIEPHPDVLKHMRKNGWMDRENVIVYETTWENAINDIASKYVFDGIYYDAFAESYEDLRNFFDSVVGLLDPETDSKFSFFNGLGADNQTFYDVYKKLVPIDLVSFGLQCTYESMPVSSKDEE-WKGAKRRYWDVSKYFLPIVTFD 356
[Close]
BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Match: sp|Q6CBX2|RMT2_YARLI (Protein arginine N-methyltransferase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) OX=284591 GN=RMT2 PE=3 SV=1)

HSP 1 Score: 188.348 bits (477), Expect = 2.291e-53
Identity = 100/237 (42.19%), Postives = 143/237 (60.34%), Query Frame = 1 
Query:  442 NYLSKEVSYTSDK--LMDSEGLAVMMDWEKDLMEKHA-AFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL---DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDV----ADPEIWKGVKTRYWYFDTYYLPKCIF 1122
            +YL  +++YT D   L+ ++   VMMDWE ++M+K A   +  AD +    +D P          VLNVGFG+GI+DT +QS  P++HYI EAHP V + +   GW  KPGV +L GRWQD +  L    V FDG+++DT++E+  DL DF +H+  LLAP TG +SF+NGL  D    + V   V  ++L   GL+ EY+ +KV+     AD  +W G+K RYW  + +YLP C F
Sbjct:  253 DYLKDKLTYTDDNKTLITTQNDGVMMDWEDEIMQKSADLLVSRADKE----SDGPV---------VLNVGFGLGIIDTYLQSKKPSKHYICEAHPDVLEKMEKDGWMDKPGVTVLVGRWQDTLPGLLSQGVYFDGMYYDTFSENYSDLVDFFDHVVGLLAP-TGVFSFFNGLGADRQVCYDVYKNVVEVDLQEYGLNVEYQVIKVNKDVTGADGHVWDGIKRRYWVVEDFYLPVCTF 475
[Close]
BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Match: sp|P0CQ68|RMT2_CRYNJ (Protein arginine N-methyltransferase 2 OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) OX=214684 GN=RMT2 PE=3 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 8.525e-47
Identity = 115/325 (35.38%), Postives = 166/325 (51.08%), Query Frame = 1 
Query:  193 YQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRA----LLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDP--TEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQD-------VVDTLDVT-----FDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKV-DVADPEIWKGVKTRYWYFDTYYLP 1110
            +QD + G S L  AA     E +++LLQ GA WNAVD+  + AG+       +E    + +    SE           L  K T +     KE      +++D++G  VMM WE+ L   +   + H   ++T ++  P ++   + + +LNVGFG+GIVD   Q  DP  + H IIEAHP V +++   G    P V+IL GRWQD       V D L  T     FD IF DT+AE  +DL+ F E +P +L    GR+SF+NGL   N   +AV+  +  L L  +GL  E+  V + +    E+WKGV+ RYW    Y LP
Sbjct:   43 FQDDDLGWSCLHYAAERKEPECLEVLLQGGAVWNAVDKWGRTAGEICLSLGDEEGWSIIRNEGIRSEDKTSAGDNLVFLKSKLTWDVGKDGKE------RVLDADGNGVMMGWEEPL--SYCIVVEHV-KRLTEEH--PKAELGAEGMSILNVGFGLGIVDRLFQECDPKPSHHTIIEAHPQVLEYIHKKGVHLLPNVRILQGRWQDWLLDGEKVGDVLSGTPDGMGFDAIFVDTFAEGYEDLKAFFEVIPDILNADNGRFSFWNGLGATNPTIYAVSSSLAELHLEDVGLQVEWHDVLIPESMREEVWKGVRRRYWDLPGYRLP 356
[Close]
BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Match: sp|P0CQ69|RMT2_CRYNB (Protein arginine N-methyltransferase 2 OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) OX=283643 GN=RMT2 PE=3 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 8.525e-47
Identity = 115/325 (35.38%), Postives = 166/325 (51.08%), Query Frame = 1 
Query:  193 YQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRA----LLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDP--TEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQD-------VVDTLDVT-----FDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKV-DVADPEIWKGVKTRYWYFDTYYLP 1110
            +QD + G S L  AA     E +++LLQ GA WNAVD+  + AG+       +E    + +    SE           L  K T +     KE      +++D++G  VMM WE+ L   +   + H   ++T ++  P ++   + + +LNVGFG+GIVD   Q  DP  + H IIEAHP V +++   G    P V+IL GRWQD       V D L  T     FD IF DT+AE  +DL+ F E +P +L    GR+SF+NGL   N   +AV+  +  L L  +GL  E+  V + +    E+WKGV+ RYW    Y LP
Sbjct:   43 FQDDDLGWSCLHYAAERKEPECLEVLLQGGAVWNAVDKWGRTAGEICLSLGDEEGWSIIRNEGIRSEDKTSAGDNLVFLKSKLTWDVGKDGKE------RVLDADGNGVMMGWEEPL--SYCIVVEHV-KRLTEEH--PKAELGAEGMSILNVGFGLGIVDRLFQECDPKPSHHTIIEAHPQVLEYIHKKGVHLLPNVRILQGRWQDWLLDGEKVGDVLSGTPDGMGFDAIFVDTFAEGYEDLKAFFEVIPDILNADNGRFSFWNGLGATNPTIYAVSSSLAELHLEDVGLQVEWHDVLIPESMREEVWKGVRRRYWDLPGYRLP 356
[Close]
BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Match: sp|Q2TZM9|RMT2_ASPOR (Protein arginine N-methyltransferase 2 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=rmt2 PE=3 SV=1)

HSP 1 Score: 168.318 bits (425), Expect = 2.161e-46
Identity = 90/232 (38.79%), Postives = 124/232 (53.45%), Query Frame = 1 
Query:  436 NSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL---DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIF 1122
            NS YL   +++ +D+L+D +   VMM WE D+M K A  +             P+S      +RVLNVG GMGIVD  IQ   P EH+IIEAHP V   +   GW  KPGV I  GRWQD++  L    V FD I++DT+AE   D R+F       L    G++SF+NG+  D    + V  +V  ++L   G   E+E + +   D E W GV+  YW  ++Y LP C +
Sbjct:  198 NSRYLDSNLTFQNDRLLDQDQNGVMMAWETDIMAKSAKKLL------------PTS-----GLRVLNVGHGMGIVDGFIQEQSPAEHHIIEAHPEVVAEMKRKGWGEKPGVTIHEGRWQDILPDLVGQGVMFDAIYYDTFAESYGDFREFFSEQVIGLLEQEGKWSFFNGMGADRQISYDVYQKVAEMDLMDAGFDVEWEEIALPKLDNE-WDGVRRAYWQIESYRLPLCKY 411
[Close]
BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Match: A0A3Q0KDE6 (Putative arginine N-methyltransferase 2 OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 377.481 bits (968), Expect = 3.229e-125
Identity = 197/390 (50.51%), Postives = 245/390 (62.82%), Query Frame = 1 
Query:   97 PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRAL-------------------------LNKKRTLNSNYLSKEVSYTSDK--LMDSEG-LAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVV--------DTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLA----------PHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDP 1128
            P    + L  A  + + E++K L+E +D DI YQD  TG+S LM+AAG G  +IV  LL EGAPWNAVDR Y CAGDYA  N+ Q+CID L++HA +SE+LL  A+                          N    LN++YL+  + Y+ D   L+D+   LAVMMDWE  +MEKHAA+ICHAD +I N    P        +RVLNVGFG+GIVDTAIQ + P  HYIIEAHP V + + S GW +KPGV+I+  +WQD V        D     F+GIFFDTYAEDD DLR+FH  LP LL+          P +GRYS+YNGLCPDNVFFH VACE  RL L  +G+SC ++ V VDV+D E+WK V  RYWYFDTY+LPKC F P
Sbjct:    6 PRQVDIALVIACHDGNFEEVKRLVEDEDADICYQDFKTGMSVLMVAAGAGHTDIVSYLLSEGAPWNAVDRSYLCAGDYAARNKQQDCIDILMNHAVMSELLLSIAVNKSDAGESVENVDSMNLTTTVNTRANNSSEPLNASYLTSRLEYSDDGKCLIDTNTHLAVMMDWETPIMEKHAAWICHAD-EINNTISSP--------LRVLNVGFGLGIVDTAIQKYSPDSHYIIEAHPEVLKKMKSEGWFAKPGVRIIPSKWQDAVVLLAKEIDDGTIPRFNGIFFDTYAEDDNDLREFHTWLPKLLSIPDQKGVEDLPFSGRYSYYNGLCPDNVFFHGVACETMRLHLKRLGISCIFDPVAVDVSDQELWKDVSQRYWYFDTYFLPKCTFAP 386
[Close]
BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Match: A0A095BZB9 (Arginine N-methyltransferase 2 OS=Schistosoma haematobium OX=6185 GN=MS3_02768 PE=4 SV=1)

HSP 1 Score: 374.4 bits (960), Expect = 5.832e-124
Identity = 198/390 (50.77%), Postives = 245/390 (62.82%), Query Frame = 1 
Query:   97 PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLL---------GRALLN----------------KKRTLNSNYLSKEVSYTSDK--LMDSEG-LAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVV--------DTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLA----------PHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDP 1128
            P    + L  A  + + E++K L+E +D DI YQD  TG+S LM+AAG G  +IV  LL EGAPWNAVDR Y CAGDYA  N+ Q+CID L++HA +SE+LL         G +L N                    LN++YLS  + Y+ D+  L+D+   LAVMMDWE  +MEKHAA+ICHAD +I +    P        +RVLN+GFG+GIVDTAIQ + P  HYIIEAHP V + + S  W +KPGVKI+  +WQD V        D     F GIFFDTYAEDD DLR+FH  LP LL+            +GRYS+YNGLCPDNVFFH VACE  RL L  +G+SC ++ V VDVAD E+WK V  RYWYFDTY+LPKC FDP
Sbjct:    6 PRQVDIALVIACHDGNFEEVKRLVEDEDADICYQDFKTGMSVLMVAAGAGHTDIVNYLLSEGAPWNAVDRSYLCAGDYAARNKQQDCIDILMNHAVMSELLLCIAVNKSDAGESLKNVDSMDLTTTVNTRANNSSEALNASYLSSRLEYSDDRKCLIDTNTHLAVMMDWETPIMEKHAAWICHAD-EIDSTISLP--------IRVLNIGFGLGIVDTAIQKYSPDSHYIIEAHPEVLKKMKSEEWFAKPGVKIIPSKWQDAVVLLAKEIDDGAIPRFSGIFFDTYAEDDNDLREFHTWLPKLLSIPNQKSVGDPSFSGRYSYYNGLCPDNVFFHGVACETMRLHLKRLGISCIFDPVAVDVADQEMWKDVSQRYWYFDTYFLPKCTFDP 386
[Close]
BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Match: A0A183MSZ7 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS19172 PE=4 SV=1)

HSP 1 Score: 373.244 bits (957), Expect = 1.770e-123
Identity = 197/390 (50.51%), Postives = 243/390 (62.31%), Query Frame = 1 
Query:   97 PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRALL-------------------------NKKRTLNSNYLSKEVSYTSDK--LMDSEG-LAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVV--------DTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLA----------PHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDP 1128
            P    + L  A  + + E++K L+E +D DI YQD  TG+S LM+AAG G  +IV  LL EGAPWNAVDR Y CAGDYA  N+ Q+CID L++HA +SE+LL  AL                          N    LN++YLS  + Y+ D+  L+D+   LAVMMDWE  +MEKHAA+ICHAD +I +    P        +RVLN+GFG+GIVDTAIQ + P  HYIIEAH  V + + S  W +KPGVKI+  +WQD V        D     F GIFFDTYAEDD DLR+FH  LP LL+            +GRYS+YNGLCPDNVFFH VACE  RL L  +G+SC ++ V VDVAD E+WK V  RYWYFDTY+LPKC FDP
Sbjct:    6 PRQVDIALVIACHDGNFEEVKRLVEDEDADICYQDFKTGMSVLMVAAGAGHTDIVNYLLSEGAPWNAVDRSYLCAGDYAARNKQQDCIDILMNHAVMSELLLCIALNKSDAGESLENVDSMDLTTTVNTRANNSSEALNASYLSSRLEYSDDRKCLIDTNTHLAVMMDWETPIMEKHAAWICHAD-EIDSTISSP--------IRVLNIGFGLGIVDTAIQKYSPDSHYIIEAHSEVLEKMKSEEWFAKPGVKIIPSKWQDAVVLLAKEIDDGTIPRFSGIFFDTYAEDDNDLREFHTWLPKLLSIPNQKGLGNPSFSGRYSYYNGLCPDNVFFHGVACETMRLHLKRLGISCIFDPVAVDVADQEMWKDVSQRYWYFDTYFLPKCTFDP 386
[Close]
BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Match: A0A3R7CGD3 (Protein arginine N-methyltransferase 2 OS=Clonorchis sinensis OX=79923 GN=rmt2 PE=4 SV=1)

HSP 1 Score: 369.777 bits (948), Expect = 5.827e-122
Identity = 191/389 (49.10%), Postives = 239/389 (61.44%), Query Frame = 1 
Query:  112 VKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGR-----------------------ALLNKK-------RTLNSNYLSKEVSYTSD--KLMDSEG-LAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTLD--------VTFDGIFFDTYAEDDQDLRDFHEHLPSLL---------APHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDP 1128
            + L  A EE ++ +++SL+E  D DI YQD  TG+S LM+AA  G  E+V+ LL EG PWNAVDR Y CAGDYA  + HQEC+DALL HA +SE+LL                          + N          TLN++YL+  + Y+ D  +L+D +  LAVMMDWE+ LM +HAA+ICHAD      +          S+RVLNVGFGMGIVD  IQ++ P+ H IIEAHP V Q +   GW SKPG++++ GRWQD V TL           FDGIFFDTYAEDD DLR FH  LP LL            TGRYS+YNG+CPDNVFFH VACE  RL L  + + C +E + VDV+DP++WK +  RYWYFDTY+LPKC F P
Sbjct:   16 LHLVIACEEGNLNKVRSLVEDADADICYQDPKTGISVLMVAASAGHTEVVRYLLAEGTPWNAVDRAYMCAGDYAAKHGHQECVDALLDHAVMSELLLSITTASTDSSNTADPDVAQGVPMECGVFNSSGPNGPPHETLNASYLASRLEYSEDGHRLVDKDTHLAVMMDWERPLMARHAAWICHADAHPVTPH----------SIRVLNVGFGMGIVDEEIQNYKPSSHVIIEAHPEVLQRMEDDGWMSKPGIQVIRGRWQDTVPTLAEEIQCGKCEPFDGIFFDTYAEDDMDLRQFHSWLPKLLRHPCTGSDGETKTGRYSYYNGVCPDNVFFHGVACETIRLHLKRLNVECIFEPISVDVSDPKLWKDLSNRYWYFDTYFLPKCTFQP 394
[Close]
BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Match: G7YEF6 (Arginine N-methyltransferase 2 OS=Clonorchis sinensis OX=79923 GN=CLF_105932 PE=4 SV=1)

HSP 1 Score: 369.392 bits (947), Expect = 7.731e-122
Identity = 191/389 (49.10%), Postives = 239/389 (61.44%), Query Frame = 1 
Query:  112 VKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGR-----------------------ALLNKK-------RTLNSNYLSKEVSYTSD--KLMDSEG-LAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTLD--------VTFDGIFFDTYAEDDQDLRDFHEHLPSLL---------APHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDP 1128
            + L  A EE ++ +++SL+E  D DI YQD  TG+S LM+AA  G  E+V+ LL EG PWNAVDR Y CAGDYA  + HQEC+DALL HA +SE+LL                          + N          TLN++YL+  + Y+ D  +L+D +  LAVMMDWE+ LM +HAA+ICHAD      +          S+RVLNVGFGMGIVD  IQ++ P+ H IIEAHP V Q +   GW SKPG++++ GRWQD V TL           FDGIFFDTYAEDD DLR FH  LP LL            TGRYS+YNG+CPDNVFFH VACE  RL L  + + C +E + VDV+DP++WK +  RYWYFDTY+LPKC F P
Sbjct:   16 LHLVIACEEGNLNKVRSLVEDADADICYQDPKTGISVLMVAASAGHTEVVRYLLAEGTPWNAVDRAYMCAGDYAAKHGHQECVDALLDHAVMSELLLSITTASTDSSNTADPDVAQGVPMECGVFNSSGPNGPPHETLNASYLASRLEYSEDGHRLVDKDTHLAVMMDWERPLMARHAAWICHADAHPVTPH----------SIRVLNVGFGMGIVDEEIQNYKPSSHVIIEAHPEVLQRIEDDGWMSKPGIQVIRGRWQDTVPTLAEEIQCGKCEPFDGIFFDTYAEDDMDLRQFHSWLPKLLRHPCTGSDGETKTGRYSYYNGVCPDNVFFHGVACETIRLHLKRLNVECIFEPISVDVSDPKLWKDLSNRYWYFDTYFLPKCTFQP 394
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Cavefish
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:103023041])

HSP 1 Score: 63.5438 bits (153), Expect = 4.210e-11
Identity = 40/102 (39.22%), Postives = 52/102 (50.98%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGR 918
            K  RVL +GFGM I  T ++S    EH+IIE +  V+Q L          V  L G W+DVV TL D  FDGI +DTY   +     +H H  + +  H  R
Sbjct:   58 KGGRVLEIGFGMAIAATKVESFPIEEHWIIECNDGVFQRLQEWAKIQPHKVVPLKGLWEDVVPTLPDNHFDGILYDTYPLTED---TWHTHQFNFIKGHAKR 156
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Cavefish
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:103023041])

HSP 1 Score: 63.1586 bits (152), Expect = 4.852e-11
Identity = 37/90 (41.11%), Postives = 47/90 (52.22%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL-DVTFDGIFFDTYAEDDQDLRDFHE 882
            K  RVL +GFGM I  T ++S    EH+IIE +  V+Q L          V  L G W+DVV TL D  FDGI +DTY   +      H+
Sbjct:   55 KGGRVLEIGFGMAIAATKVESFPIEEHWIIECNDGVFQRLQEWAKIQPHKVVPLKGLWEDVVPTLPDNHFDGILYDTYPLTEDTWHTHHQ 144
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Sea Lamprey
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:796865])

HSP 1 Score: 65.855 bits (159), Expect = 1.181e-12
Identity = 52/162 (32.10%), Postives = 69/162 (42.59%), Query Frame = 1 
Query:  472 SDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI--LFGRWQDVVDTLDVT-FDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPD 948
            +D  +   G  VM  WE   M K A                  S    K  RVL +GFGM I  T I+ HD  EH+I+E +  V+  L    WA +   K+  L G W+DVV TL    FDGI +DTY   ++               HT +++F  G   D
Sbjct:   29 TDTHLQIMGKPVMERWEAPYMHKLA------------------SIASSKGGRVLEIGFGMAIAATKIEEHDIAEHWIVECNDGVFARLQR--WAGQQLHKVVPLKGLWEDVVPTLPKGHFDGILYDTYPLSEETW-------------HTHQFNFIQGYAYD 157
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Yeast
Match: RMT2 (Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000002873])

HSP 1 Score: 157.532 bits (397), Expect = 3.858e-44
Identity = 108/336 (32.14%), Postives = 161/336 (47.92%), Query Frame = 1 
Query:  247 CLEIVKLLLQEGAPWNAVDRKYKCAGD-YAHMNRHQEC-IDALLHHATISEMLLGRALL---------------------------NKKRTLNSN----------YLSKEVSYTSDKLMDSEGL-AVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL----DVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIF 1122
             ++++ +L + GA WN +D + K  GD +   N+ +E  +   L  A +S  LL R L                             K+ ++ S+          YL  E+ Y  D L+  E    VMMDWE  +ME  A+     D + TN            S  +LN+GFGMGI+DT IQ+  P  HYI EAHP V   +   GW  K  V IL GRWQD ++ L    +V FDGI++DT++E  QD+ D ++ +  L+ P  G +SF+NGL  D    + V  E+  +++   G+ C+Y    +D   P+ W  VK  Y+  + YY P+  F
Sbjct:   91 VMDMMNILFEYGAGWNFIDYEDKTVGDLFLERNQSRESPLYRRLVEAGVSAELLLRKLNGGDVEFLDTDELIGIEPEESVQTAVDGQKEESVGSDDDATAANQQVYLKTELEYKDDALITKENKDGVMMDWETKIMEL-ASETLFPDPEATN------------SATILNIGFGMGIIDTFIQARKPYRHYICEAHPDVLAKMKMDGWYEKDNVVILEGRWQDTLNNLLDKGEVFFDGIYYDTFSEHYQDILDLYDVVVGLIKPE-GVFSFFNGLGADRSLCYDVYKEIVEIDVATYGMKCDYTRYSLDEQLPD-WNDVKRSYFNCNYYYHPRITF 411
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Nematostella
Match: EDO46495 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ42])

HSP 1 Score: 59.6918 bits (143), Expect = 2.334e-10
Identity = 42/118 (35.59%), Postives = 52/118 (44.07%), Query Frame = 1 
Query:  496 GLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTL-DVTFDGIFFDTY 846
            G  VM  WE   M K A+                         RVL +GFG+ I  T IQS    EH IIE +  V++ L      +   V    G W+DVV TL D +FDGI +DTY
Sbjct:   30 GKPVMERWETPYMHKLASIAASNGG------------------RVLEIGFGLAISATKIQSFPIDEHVIIECNDGVFKRLEKFAENAAHKVTPKKGLWEDVVPTLEDNSFDGILYDTY 129
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Medaka
Match: gamt (guanidinoacetate N-methyltransferase [Source:NCBI gene;Acc:101166292])

HSP 1 Score: 57.7658 bits (138), Expect = 3.695e-9
Identity = 40/92 (43.48%), Postives = 51/92 (55.43%), Query Frame = 1 
Query:  616 KSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWA-SKP-GVKILFGRWQDVVDTLDVT-FDGIFFDTY--AEDDQDLRDF 876
            K  RVL +GFGM I  T ++S    EH+IIE +  V+  L    WA S+P  V  L G W++VV TL    FDGI +DTY  +ED      F
Sbjct:   59 KGGRVLEIGFGMAIAATKLESFPIEEHWIIECNDGVFARL--ENWAKSQPHKVVPLKGLWEEVVPTLPENHFDGILYDTYPLSEDTWHTHQF 148
[Close]
BLAST of Arginine N-methyltransferase 2 vs. Planmine SMEST
Match: SMESG000021268.1 (SMESG000021268.1)

HSP 1 Score: 717.613 bits (1851), Expect = 0.000e+0
Identity = 341/346 (98.55%), Postives = 342/346 (98.84%), Query Frame = 1 
Query:   97 PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRALLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCIFDPSI 1134
            PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRALLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKI FGRWQDVVDTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCI  P+ 
Sbjct:   10 PTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTGVSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECIDALLHHATISEMLLGRALLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMMDWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVDTAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKIFFGRWQDVVDTLDVTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFHAVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPKCILIPAF 355
The following BLAST results are available for this feature:
BLAST of Arginine N-methyltransferase 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
GAMT1.778e-1034.03guanidinoacetate N-methyltransferase [Source:HGNC ... [more]
GAMT5.045e-1035.34guanidinoacetate N-methyltransferase [Source:HGNC ... [more]
GAMT6.914e-1039.60guanidinoacetate N-methyltransferase [Source:HGNC ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gamt6.339e-1137.25guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
gamt6.339e-1137.25guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gamt2.407e-1239.09guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
gamt2.886e-1239.09guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Gamt2.110e-937.50guanidinoacetate methyltransferase [Source:MGI Sym... [more]
Gamt3.087e-941.18guanidinoacetate methyltransferase [Source:MGI Sym... [more]
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BLAST of Arginine N-methyltransferase 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q10170|RMT2_SCHPO1.243e-5633.52Protein arginine N-methyltransferase 2 OS=Schizosa... [more]
sp|Q6CBX2|RMT2_YARLI2.291e-5342.19Protein arginine N-methyltransferase 2 OS=Yarrowia... [more]
sp|P0CQ68|RMT2_CRYNJ8.525e-4735.38Protein arginine N-methyltransferase 2 OS=Cryptoco... [more]
sp|P0CQ69|RMT2_CRYNB8.525e-4735.38Protein arginine N-methyltransferase 2 OS=Cryptoco... [more]
sp|Q2TZM9|RMT2_ASPOR2.161e-4638.79Protein arginine N-methyltransferase 2 OS=Aspergil... [more]
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BLAST of Arginine N-methyltransferase 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3Q0KDE63.229e-12550.51Putative arginine N-methyltransferase 2 OS=Schisto... [more]
A0A095BZB95.832e-12450.77Arginine N-methyltransferase 2 OS=Schistosoma haem... [more]
A0A183MSZ71.770e-12350.51Uncharacterized protein OS=Schistosoma margrebowie... [more]
A0A3R7CGD35.827e-12249.10Protein arginine N-methyltransferase 2 OS=Clonorch... [more]
G7YEF67.731e-12249.10Arginine N-methyltransferase 2 OS=Clonorchis sinen... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gamt4.210e-1139.22guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
gamt4.852e-1141.11guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gamt1.181e-1232.10guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
RMT23.858e-4432.14Arginine N5 methyltransferase; methylates ribosoma... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO464952.334e-1035.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gamt3.695e-943.48guanidinoacetate N-methyltransferase [Source:NCBI ... [more]
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BLAST of Arginine N-methyltransferase 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000021268.10.000e+098.55SMESG000021268.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021327 ID=SMED30021327|Name=Arginine N-methyltransferase 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1300bp
TCTAAATTCACGGTAGTTTAAATATTCAATAATTTAAATTTTTCGCACAT
ATTGGATATAAAAATGGAAATGGAATTAGAAATTGAAGAAATTAAACCAA
CAACTTCTATAGTCAAATTATTTCAAGCAATAGAAGAAAAAGATATCGAA
CAAATTAAGAGTTTAATCGAATTAGATGATTGTGATATTACTTATCAAGA
TAAAAATACTGGAGTCAGCCCATTAATGATAGCAGCTGGTGTTGGTTGTC
TGGAAATTGTTAAGTTACTTCTACAAGAAGGAGCCCCTTGGAATGCAGTT
GATAGAAAATACAAATGCGCCGGAGATTATGCACACATGAATAGACATCA
AGAATGTATCGATGCTCTACTTCACCACGCTACTATTTCTGAAATGCTTT
TAGGACGTGCACTTTTAAATAAAAAAAGGACTCTGAATTCGAATTATTTG
AGCAAGGAAGTTAGTTATACGTCCGACAAATTGATGGATTCTGAAGGATT
AGCAGTAATGATGGATTGGGAAAAGGATTTAATGGAGAAACATGCAGCTT
TCATTTGTCATGCGGACAATCAAATAACAAATGATAATGATGAACCGAGC
TCCAAATGTCAAAGAAAATCCGTCCGGGTGCTCAATGTCGGATTTGGGAT
GGGAATTGTCGACACCGCTATCCAATCGCACGATCCAACTGAGCATTACA
TAATCGAGGCTCATCCGACAGTTTATCAGCATCTAATGTCGAGTGGCTGG
GCCAGCAAGCCTGGAGTCAAAATCCTTTTCGGCCGGTGGCAGGACGTTGT
TGACACTCTCGATGTGACTTTCGATGGGATTTTCTTCGATACCTACGCGG
AGGACGATCAAGATCTGAGGGATTTCCACGAGCACCTACCGAGCTTATTG
GCACCTCATACCGGTCGATACTCATTCTATAACGGCCTCTGTCCTGATAA
TGTTTTCTTTCACGCCGTCGCTTGTGAGGTTACTCGGTTGGAGTTGAATC
ACATCGGTCTCAGCTGCGAATATGAATCCGTCAAGGTCGACGTTGCTGAT
CCCGAGATTTGGAAAGGCGTCAAAACCAGATATTGGTATTTCGACACGTA
TTATTTACCAAAATGCATTTTTGATCCCAGCATTTGAATAAATTATGACT
TCGAAATTTCATTTTTATAATAAACTACTTATTAATTTATAAGTAGATAA
CTAATTGGGTTTTAAATATTGTAATGGAGTATTCCAACTTTTACTGTACA
CGATTAAGCACTAGTTTGAATAGTGTTGTATTAAATAAATTTGGATCATG
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protein sequence of SMED30021327-orf-1

>SMED30021327-orf-1 ID=SMED30021327-orf-1|Name=SMED30021327-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=358bp
MEMELEIEEIKPTTSIVKLFQAIEEKDIEQIKSLIELDDCDITYQDKNTG
VSPLMIAAGVGCLEIVKLLLQEGAPWNAVDRKYKCAGDYAHMNRHQECID
ALLHHATISEMLLGRALLNKKRTLNSNYLSKEVSYTSDKLMDSEGLAVMM
DWEKDLMEKHAAFICHADNQITNDNDEPSSKCQRKSVRVLNVGFGMGIVD
TAIQSHDPTEHYIIEAHPTVYQHLMSSGWASKPGVKILFGRWQDVVDTLD
VTFDGIFFDTYAEDDQDLRDFHEHLPSLLAPHTGRYSFYNGLCPDNVFFH
AVACEVTRLELNHIGLSCEYESVKVDVADPEIWKGVKTRYWYFDTYYLPK
CIFDPSI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002056medial muscle cell
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR036770Ankyrin_rpt-contain_sf
IPR017408Arginine_N-MeTrfase_2
IPR029063SAM-dependent_MTases
IPR020683Ankyrin_rpt-contain_dom
IPR002110Ankyrin_rpt
IPR026480RMT2_dom
Vocabulary: molecular function
TermDefinition
GO:0016274protein-arginine N-methyltransferase activity
GO:0005515protein binding
GO:0008168methyltransferase activity
GO:0016740transferase activity
Vocabulary: biological process
TermDefinition
GO:0032259methylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 11..127
e-value: 4.9E-16
score: 60.7
IPR036770Ankyrin repeat-containing domain superfamilySUPERFAMILYSSF48403Ankyrin repeatcoord: 17..106
IPR017408Arginine N-methyltransferase 2PIRSFPIRSF038148Rmt2coord: 2..118
e-value: 1.4E-11
score: 41.4
coord: 113..352
e-value: 6.8E-87
score: 289.5
IPR020683Ankyrin repeat-containing domainPFAMPF12796Ank_2coord: 17..104
e-value: 1.3E-7
score: 32.0
IPR020683Ankyrin repeat-containing domainPROSITEPS50297ANK_REP_REGIONcoord: 12..79
score: 12.726
NoneNo IPR availableGENE3DG3DSA:3.40.50.150coord: 128..351
e-value: 3.7E-70
score: 238.0
NoneNo IPR availablePANTHERPTHR32379FAMILY NOT NAMEDcoord: 16..350
NoneNo IPR availableCDDcd02440AdoMet_MTasescoord: 186..279
e-value: 0.00107652
score: 36.2539
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 47..79
score: 12.129
IPR026480Arginine N-methyltransferase 2-like domainPROSITEPS51559SAM_RMT2coord: 119..355
score: 57.55
IPR029063S-adenosyl-L-methionine-dependent methyltransferaseSUPERFAMILYSSF53335S-adenosyl-L-methionine-dependent methyltransferasescoord: 129..350