sim protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021317 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 13
Homology
BLAST of sim protein vs. Ensembl Human
Match: SIM1 (SIM bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10882]) HSP 1 Score: 500.36 bits (1287), Expect = 5.624e-167 Identity = 254/394 (64.47%), Postives = 305/394 (77.41%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP + N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-AFSYTSSSTPTMTDN 367
BLAST of sim protein vs. Ensembl Human
Match: SIM1 (SIM bHLH transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:10882]) HSP 1 Score: 500.36 bits (1287), Expect = 5.624e-167 Identity = 254/394 (64.47%), Postives = 305/394 (77.41%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP + N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-AFSYTSSSTPTMTDN 367
BLAST of sim protein vs. Ensembl Human
Match: SIM2 (SIM bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10883]) HSP 1 Score: 486.108 bits (1250), Expect = 9.418e-163 Identity = 239/374 (63.90%), Postives = 295/374 (78.88%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLG+ W DG + KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ + + QEYEIE+SF +R+KCVLAKRNAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K++SNMFMFRA+LDL+LIFLD++V +TGYEPQDLIEKT Y +H CD+ H+R++H H +L+KGQV TKYYR L++ GGW W+QSY T+VHNSRSSRPHC+VSVNYVL+++E K+L L +Q+ T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDG---VAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAH-----QPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYM-LDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAH----------------HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVST 349
BLAST of sim protein vs. Ensembl Human
Match: SIM2 (SIM bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10883]) HSP 1 Score: 374.785 bits (961), Expect = 4.561e-122 Identity = 185/311 (59.49%), Postives = 237/311 (76.21%), Query Frame = 2
Query: 251 WHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
W DG + KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ + + QEYEIE+SF +R+KCVLAKRNAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K++SNMFMFRA+LDL+LIFLD++V +TGYEPQDLIEKT Y +H CD+ H+R++H H +L+KGQV TKYYR L++ GGW W+QSY T+VHNSRSSRPHC+VSVNYVL+++E K+L L +Q+ T
Sbjct: 2 WGQPSRAGPLDG---VAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAH-----QPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYM-LDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAH----------------HLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVST 287
BLAST of sim protein vs. Ensembl Human
Match: NPAS3 (neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]) HSP 1 Score: 292.738 bits (748), Expect = 2.236e-86 Identity = 164/411 (39.90%), Postives = 235/411 (57.18%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHIS----NALFDGEN-----------TIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC----------------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAKLLPLP+AITSQLDKASIIRLT SYLKMR+ F + W+ + N G E LGS++LQ+L+GFVF + +GK +YISET S++LGLSQVELTG+S+F+Y+HP DH EM+ L P V S S + + +E+SF IR+K L KR + + GYKVIH +G L+++ ++ Q MGL+ V H+LPP + E+++ +MF+ R N+DL +I+ + +++ P D++ K Y FIH D+ +RHSH +L KGQ +TKYYR++ +NGG+ W+QS TI N++++ ++ VNY+LS+ E KD + Q+
Sbjct: 23 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRD-FANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHL----------------DLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 416
BLAST of sim protein vs. Ensembl Celegans
Match: hif-1 (Hypoxia-inducible factor 1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGD2]) HSP 1 Score: 120.553 bits (301), Expect = 5.314e-28 Identity = 99/389 (25.45%), Postives = 190/389 (48.84%), Query Frame = 2
Query: 41 KNQSTDKMKEKSKNAARNRREKENAEFVELAKLLPL-PSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNA--GLTNGGYK----VIH----CSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQ-SYITIVHNSRSSRPHCVVSVNYVLSDVEAKD-LILQTDQI 1168
+ ++ ++ +E S++AAR+RR KE+ F +L +P+ + LD+ +++R+ ++ ++R + L N I+N ++ E+TI + L+GFV ++ +D I+Y++E+ +++LGL+Q +LTG ++ +++HP+D++E L P + + + + +R+K V++ R L + YK ++H G++ ITI Q N A+ + TE M + F R D+R+ F+ K + E + L+ +FY+ +H D++ V S M E + KG + T YYR + N W+Q TI H ++ + V+ V+YVL A++ L++ TD +
Sbjct: 5 RKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVW-TEDTIA--------ECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKML--HKPRGEDTDTTGINMV-----LRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAM------TKYTESPMGA--FTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKS------MKELF----------AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSM 353
BLAST of sim protein vs. Ensembl Celegans
Match: hif-1 (Hypoxia-inducible factor 1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGD2]) HSP 1 Score: 120.553 bits (301), Expect = 5.585e-28 Identity = 99/389 (25.45%), Postives = 190/389 (48.84%), Query Frame = 2
Query: 41 KNQSTDKMKEKSKNAARNRREKENAEFVELAKLLPL-PSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNA--GLTNGGYK----VIH----CSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQ-SYITIVHNSRSSRPHCVVSVNYVLSDVEAKD-LILQTDQI 1168
+ ++ ++ +E S++AAR+RR KE+ F +L +P+ + LD+ +++R+ ++ ++R + L N I+N ++ E+TI + L+GFV ++ +D I+Y++E+ +++LGL+Q +LTG ++ +++HP+D++E L P + + + + +R+K V++ R L + YK ++H G++ ITI Q N A+ + TE M + F R D+R+ F+ K + E + L+ +FY+ +H D++ V S M E + KG + T YYR + N W+Q TI H ++ + V+ V+YVL A++ L++ TD +
Sbjct: 5 RKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVW-TEDTIA--------ECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKML--HKPRGEDTDTTGINMV-----LRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAM------TKYTESPMGA--FTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKS------MKELF----------AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSM 353
BLAST of sim protein vs. Ensembl Celegans
Match: hif-1 (Hypoxia-inducible factor 1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGD2]) HSP 1 Score: 119.398 bits (298), Expect = 1.244e-27 Identity = 99/384 (25.78%), Postives = 187/384 (48.70%), Query Frame = 2
Query: 56 DKMKEKSKNAARNRREKENAEFVELAKLLPL-PSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNA--GLTNGGYK----VIH----CSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQ-SYITIVHNSRSSRPHCVVSVNYVLSDVEAKD-LILQTDQI 1168
++ +E S++AAR+RR KE+ F +L +P+ + LD+ +++R+ ++ ++R + L N I+N ++ E+TI + L+GFV ++ +D I+Y++E+ +++LGL+Q +LTG ++ +++HP+D++E L P + + + + +R+K V++ R L + YK ++H G++ ITI Q N A+ + TE M + F R D+R+ F+ K + E + L+ +FY+ +H D++ V S M E + KG + T YYR + N W+Q TI H ++ + V+ V+YVL A++ L++ TD +
Sbjct: 2 ERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVW-TEDTIA--------ECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKML--HKPRGEDTDTTGINMV-----LRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAM------TKYTESPMGA--FTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKS------MKELF----------AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSM 345
BLAST of sim protein vs. Ensembl Celegans
Match: hif-1 (Hypoxia-inducible factor 1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGD2]) HSP 1 Score: 119.013 bits (297), Expect = 1.403e-27 Identity = 99/384 (25.78%), Postives = 187/384 (48.70%), Query Frame = 2
Query: 56 DKMKEKSKNAARNRREKENAEFVELAKLLPL-PSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNA--GLTNGGYK----VIH----CSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQ-SYITIVHNSRSSRPHCVVSVNYVLSDVEAKD-LILQTDQI 1168
++ +E S++AAR+RR KE+ F +L +P+ + LD+ +++R+ ++ ++R + L N I+N ++ E+TI + L+GFV ++ +D I+Y++E+ +++LGL+Q +LTG ++ +++HP+D++E L P + + + + +R+K V++ R L + YK ++H G++ ITI Q N A+ + TE M + F R D+R+ F+ K + E + L+ +FY+ +H D++ V S M E + KG + T YYR + N W+Q TI H ++ + V+ V+YVL A++ L++ TD +
Sbjct: 2 ERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRKTAGNVLENNLDNEITNEVW-TEDTIA--------ECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLTGRALRDFLHPSDYDEFDKQSKML--HKPRGEDTDTTGINMV-----LRMKTVISPRGRCLNLKSALYKSVSFLVHSKVSTGGHVSFMQGITIPAGQGTTNANASAM------TKYTESPMGA--FTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVSKS------MKELF----------AKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLVVCTDSM 345
BLAST of sim protein vs. Ensembl Celegans
Match: hlh-34 (Helix-loop-helix 34 [Source:UniProtKB/Swiss-Prot;Acc:P90953]) HSP 1 Score: 114.005 bits (284), Expect = 1.916e-27 Identity = 90/292 (30.82%), Postives = 149/292 (51.03%), Query Frame = 2
Query: 44 NQSTDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQ-LDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKR---NAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTG---YEPQDLIEKTFYQFIHTCD 898
N S +K K SK+ A+ RR+ EN EF +LA LPL AI+ Q +DK +++RL ++Y+K+ N+F G+ + S + G +++ + L L+GF ++ G ++YISET S++LGLSQVE+TGN++ +YIH D ++C SA+ + + ++R+K L KR +A + GYKV+ IT+ N N +IA + +P ++ + + SN F+ ++DL + F D K L Y ++ + Y I D
Sbjct: 4 NLSEEKQK-PSKSQAQQRRQMENYEFSQLANELPLARAISGQHIDKTTMVRLATAYIKLHNIF----GQSQRAYSSADYYYGSDSL---WTNNHLDLLDGFFVILDRRGDVLYISETISIYLGLSQVEMTGNAMVDYIHEQD-------INCFNSAL-------NYCDLNWPQMCNVRVKSSLTKRANKDAVRASPGYKVLRLE--------ITMGPN---TNTRMIAC-YPMPTPVLSTVTIPSNSFVIITSIDLHITFADEKAHQLLNNPFYPDSNIKGMSLYSLIDISD 261
BLAST of sim protein vs. Ensembl Fly
Match: sim (gene:FBgn0004666 transcript:FBtr0082711) HSP 1 Score: 461.07 bits (1185), Expect = 1.945e-153 Identity = 243/397 (61.21%), Postives = 285/397 (71.79%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP---------SAVPXXX-----------XXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQ--CIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQ--IMTRE 1180
MKEKSKNAAR RREKEN EF ELAKLLPLP+AITSQLDKAS+IRLT+SYLKMR VFPDGLGE W + S A+ G KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSIFEYIH D +EM+++LS P + P + S EIEK+F +R+KCVLAKRNAGLT G+KVIHCSGYLK + Q IQN+GL+AVGHSLP SA+TE+K+H NMFMFRA LD++LIF D +V+ LTGYEPQDLIEKT YQ+IH DI+ +R SHQ +L KGQV TKYYRFLT+ GGW W+QSY T+VHNSRSSR +VSVNYVLS+ E KDL+L Q ++ RE
Sbjct: 1 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS--SPAMQRGATI--KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQI----------------LLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKRE 377
BLAST of sim protein vs. Ensembl Fly
Match: sim (gene:FBgn0004666 transcript:FBtr0334613) HSP 1 Score: 461.455 bits (1186), Expect = 2.147e-153 Identity = 244/400 (61.00%), Postives = 286/400 (71.50%), Query Frame = 2
Query: 53 TDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP---------SAVPXXX-----------XXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQ--CIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQ--IMTRE 1180
T MKEKSKNAAR RREKEN EF ELAKLLPLP+AITSQLDKAS+IRLT+SYLKMR VFPDGLGE W + S A+ G KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSIFEYIH D +EM+++LS P + P + S EIEK+F +R+KCVLAKRNAGLT G+KVIHCSGYLK + Q IQN+GL+AVGHSLP SA+TE+K+H NMFMFRA LD++LIF D +V+ LTGYEPQDLIEKT YQ+IH DI+ +R SHQ +L KGQV TKYYRFLT+ GGW W+QSY T+VHNSRSSR +VSVNYVLS+ E KDL+L Q ++ RE
Sbjct: 9 TCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS--SPAMQRGATI--KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQI----------------LLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKRE 388
BLAST of sim protein vs. Ensembl Fly
Match: sim (gene:FBgn0004666 transcript:FBtr0082710) HSP 1 Score: 460.685 bits (1184), Expect = 5.879e-153 Identity = 244/400 (61.00%), Postives = 286/400 (71.50%), Query Frame = 2
Query: 53 TDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP---------SAVPXXX-----------XXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQ--CIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQ--IMTRE 1180
T MKEKSKNAAR RREKEN EF ELAKLLPLP+AITSQLDKAS+IRLT+SYLKMR VFPDGLGE W + S A+ G KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSIFEYIH D +EM+++LS P + P + S EIEK+F +R+KCVLAKRNAGLT G+KVIHCSGYLK + Q IQN+GL+AVGHSLP SA+TE+K+H NMFMFRA LD++LIF D +V+ LTGYEPQDLIEKT YQ+IH DI+ +R SHQ +L KGQV TKYYRFLT+ GGW W+QSY T+VHNSRSSR +VSVNYVLS+ E KDL+L Q ++ RE
Sbjct: 22 TCAMKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS--SPAMQRGATI--KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQI----------------LLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKRE 401
BLAST of sim protein vs. Ensembl Fly
Match: sim (gene:FBgn0004666 transcript:FBtr0334614) HSP 1 Score: 457.988 bits (1177), Expect = 4.491e-152 Identity = 243/405 (60.00%), Postives = 285/405 (70.37%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP-----------------SAVPXXX-----------XXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQ--CIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQ--IMTRE 1180
MKEKSKNAAR RREKEN EF ELAKLLPLP+AITSQLDKAS+IRLT+SYLKMR VFPDGLGE W + S A+ G KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSIFEYIH D +EM+++LS P + P + S EIEK+F +R+KCVLAKRNAGLT G+KVIHCSGYLK + Q IQN+GL+AVGHSLP SA+TE+K+H NMFMFRA LD++LIF D +V+ LTGYEPQDLIEKT YQ+IH DI+ +R SHQ +L KGQV TKYYRFLT+ GGW W+QSY T+VHNSRSSR +VSVNYVLS+ E KDL+L Q ++ RE
Sbjct: 1 MKEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS--SPAMQRGATI--KELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYIHNYDQDEMNAILSLHPHINQHPAAFLNSLQLAQTHTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLIQNLGLVAVGHSLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSHQI----------------LLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKRE 385
BLAST of sim protein vs. Ensembl Fly
Match: trh (gene:FBgn0262139 transcript:FBtr0304122) HSP 1 Score: 253.832 bits (647), Expect = 3.392e-72 Identity = 150/428 (35.05%), Postives = 230/428 (53.74%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEI-WHNHISNALFDGENTI---------EKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEE--------------------------------MSSLLSCL------------PSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDN 1186
KEKS++AAR+RR KEN EF ELAK+LPLP+AITSQLDKASIIRLT SYLK+R+ G G+ W S++ I E+ G+++LQ+L+GF +AADG+ +YISET S++LGLSQVE+TG+SIF+YIH ADH E M+S S P S + S ++SF +R+K L KR + GY+V+ L+ + + +G++A+ +LPP ++ E+++ +MF+ R N DLR+ + +V+ L Y P+DL+ K+ Y H D +R SH ++ KGQV+T YYR + ++GG+ W+Q+ T+V +++++ ++ VNYV+S+ E +++IL Q+ D+
Sbjct: 125 KEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDF--SGHGDPPWTREASSSSKLKSAAIRRSPAVDLFEQHQGTHILQSLDGFALAVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYIHQADHSEIADQLGLSLTSGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTHGTNNPDVAASMTQASTSGYKGYDRSFCVRMKSTLTKRGCHFKSSGYRVVLLLCKLRPQYTFSHSRKSQPPLLGMVALAIALPPPSVHEIRLECDMFVTRVNFDLRVAHCEPRVSDLLDYSPEDLVNKSLYSLCHAEDANRLRKSHS----------------DLIEKGQVLTGYYRLMNKSGGYTWLQTCATVVCSTKNADEQNIICVNYVISNRENENMILDCCQLEPSPDS 534
BLAST of sim protein vs. Ensembl Zebrafish
Match: sim1b (SIM bHLH transcription factor 1b [Source:ZFIN;Acc:ZDB-GENE-041210-5]) HSP 1 Score: 496.893 bits (1278), Expect = 2.575e-168 Identity = 250/384 (65.10%), Postives = 303/384 (78.91%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQ--------TLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTRE 1180
MKEKSK AAR RREKEN+EF ELAK+LPLPSAITSQLDKASIIRLTSSYLKMR VFP GLGE+W + GEN ELGS+LLQ TL+GF+F++AADGKIMYISETASVHLGLSQVELTGNSI+EY+HPADH+EM+++L+ PS +S++ QEYE+E+SF +R+KCVLAKRNAGLT+GGYKVIHCSGYLK++ ++D + C QN+GL+AVGH+LPPSA+TE+K+HSNMFMFRA+LD++LIFLD++V+ LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL++ GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K LIL DQ+ R+
Sbjct: 1 MKEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTSSYLKMRLVFPQGLGEVWGQ--AGRTRSGENP-SHELGSHLLQVIISKMLQTLDGFIFVVAADGKIMYISETASVHLGLSQVELTGNSIYEYVHPADHDEMAAVLTPQPS-----YHSHFVQEYEVERSFFLRMKCVLAKRNAGLTSGGYKVIHCSGYLKIRQF-SLDASPFDGCYQNVGLVAVGHTLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVSDLTGYEPQDLIEKTLYHHVHCCDSFHLRCAH----------------HLLLVKGQVTTKYYRFLSKRGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLILSLDQLNPRK 359
BLAST of sim protein vs. Ensembl Zebrafish
Match: sim1a (SIM bHLH transcription factor 1a [Source:NCBI gene;Acc:260351]) HSP 1 Score: 497.664 bits (1280), Expect = 1.788e-166 Identity = 262/444 (59.01%), Postives = 322/444 (72.52%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHP 1381
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W H+S EN + +ELGS+LLQTL+GF+F++A DGKI+YISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ EYE+E+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H+CD H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ + + S Y P++ + + +S+ R+ YS +P R + P S +S P
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESW-GHVSRTT-SLEN-VGRELGSHLLQTLDGFIFVVAPDGKILYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVHEYEMERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQAASTKP-SFTYNSPSNPVTENRRVGKS-RVSRTKTKTRLSPYSQYPGFPTDRSESDQDSPWGGSPLTDSASP 416
BLAST of sim protein vs. Ensembl Zebrafish
Match: sim1a (SIM bHLH transcription factor 1a [Source:NCBI gene;Acc:260351]) HSP 1 Score: 497.664 bits (1280), Expect = 1.788e-166 Identity = 262/444 (59.01%), Postives = 322/444 (72.52%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHP 1381
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W H+S EN + +ELGS+LLQTL+GF+F++A DGKI+YISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ EYE+E+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H+CD H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ + + S Y P++ + + +S+ R+ YS +P R + P S +S P
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESW-GHVSRTT-SLEN-VGRELGSHLLQTLDGFIFVVAPDGKILYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVHEYEMERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQAASTKP-SFTYNSPSNPVTENRRVGKS-RVSRTKTKTRLSPYSQYPGFPTDRSESDQDSPWGGSPLTDSASP 416
BLAST of sim protein vs. Ensembl Zebrafish
Match: npas1 (neuronal PAS domain protein 1 [Source:ZFIN;Acc:ZDB-GENE-060503-934]) HSP 1 Score: 296.975 bits (759), Expect = 1.326e-92 Identity = 165/410 (40.24%), Postives = 234/410 (57.07%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGEN---------------TIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP--------------------------SAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQN-MGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS+NAAR+RR KEN EF ELAK+LPLP AITSQLDKASIIRLT SYL MR+ G W + L +GEN E+ LG++LLQ+L+GFVF+++ +G+ +YISET S++LGLSQVELTG+S+F+YIHPADH EM+ L P + P+ E+ F IR+K L KR + + GYKVIH +G ++ + + ++ + MGL+A+ H+LPPS + E++M S+MF+FR N+DL++ + + +++ P +++ T Y FIH D+ VR SH+ +L KGQV+T YYR+L R GG+ W+QS T+ N ++ V+ VNYVLS E D+ L Q+
Sbjct: 38 KEKSRNAARSRRGKENFEFFELAKMLPLPGAITSQLDKASIIRLTISYLHMRHFASQG-DPPW-----SPLMEGENNCSKVRRTSHSLVTDIFEQHLGAHLLQSLDGFVFVVSQEGRFLYISETVSIYLGLSQVELTGSSVFDYIHPADHVEMAERLGIRPHLRAEAGCQTSHESASSSASTSSLAGTPEPAPHSPCSPVRELSERGFFIRMKSTLTKRGLHVKSSGYKVIHVTGRIRCRPALVPSSSRALHRPMGLVALAHTLPPSTLNEVRMESHMFVFRVNMDLQVTYCENRISEYMDLSPAEVVGHTCYHFIHAEDLDTVRQSHE----------------DLLRKGQVVTGYYRWLQRRGGYLWIQSCATVSINHKAPHERNVIWVNYVLSRPELADMPLDLLQL 425
BLAST of sim protein vs. Ensembl Zebrafish
Match: npas1 (neuronal PAS domain protein 1 [Source:ZFIN;Acc:ZDB-GENE-060503-934]) HSP 1 Score: 299.286 bits (765), Expect = 3.322e-90 Identity = 165/410 (40.24%), Postives = 234/410 (57.07%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENT---------------IEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP--------------------------SAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQN-MGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS+NAAR+RR KEN EF ELAK+LPLP AITSQLDKASIIRLT SYL MR+ G W + L +GEN E+ LG++LLQ+L+GFVF+++ +G+ +YISET S++LGLSQVELTG+S+F+YIHPADH EM+ L P + P+ E+ F IR+K L KR + + GYKVIH +G ++ + + ++ + MGL+A+ H+LPPS + E++M S+MF+FR N+DL++ + + +++ P +++ T Y FIH D+ VR SH+ +L KGQV+T YYR+L R GG+ W+QS T+ N ++ V+ VNYVLS E D+ L Q+
Sbjct: 38 KEKSRNAARSRRGKENFEFFELAKMLPLPGAITSQLDKASIIRLTISYLHMRHFASQG-DPPW-----SPLMEGENNCSKVRRTSHSLVTDIFEQHLGAHLLQSLDGFVFVVSQEGRFLYISETVSIYLGLSQVELTGSSVFDYIHPADHVEMAERLGIRPHLRAEAGCQTSHESASSSASTSSLAGTPEPAPHSPCSPVRELSERGFFIRMKSTLTKRGLHVKSSGYKVIHVTGRIRCRPALVPSSSRALHRPMGLVALAHTLPPSTLNEVRMESHMFVFRVNMDLQVTYCENRISEYMDLSPAEVVGHTCYHFIHAEDLDTVRQSHE----------------DLLRKGQVVTGYYRWLQRRGGYLWIQSCATVSINHKAPHERNVIWVNYVLSRPELADMPLDLLQL 425
BLAST of sim protein vs. Ensembl Xenopus
Match: f5 (coagulation factor V (proaccelerin, labile factor) [Source:Xenbase;Acc:XB-GENE-987398]) HSP 1 Score: 499.204 bits (1284), Expect = 7.327e-172 Identity = 262/424 (61.79%), Postives = 316/424 (74.53%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNY---SMSSDYP 1312
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ+ T+ P S S N +N S++ R+ N S +S YP
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRPSTLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTK------------PPFSYTSSNPTINDSRKSSKARLSNTKSKSRTSPYP 386
BLAST of sim protein vs. Ensembl Xenopus
Match: f5 (coagulation factor V (proaccelerin, labile factor) [Source:Xenbase;Acc:XB-GENE-987398]) HSP 1 Score: 498.049 bits (1281), Expect = 1.517e-169 Identity = 250/376 (66.49%), Postives = 299/376 (79.52%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTR 1177
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ+ T+
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRPSTLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTK 350
BLAST of sim protein vs. Ensembl Xenopus
Match: f5 (coagulation factor V (proaccelerin, labile factor) [Source:Xenbase;Acc:XB-GENE-987398]) HSP 1 Score: 502.286 bits (1292), Expect = 3.245e-168 Identity = 268/459 (58.39%), Postives = 328/459 (71.46%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNY-SMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAP 1423
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ+ T+ P S S N +N S++ R+ N S S P P+ + + ++ + S H S T T +P
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRPSTLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTK------------PPFSYTSSNPTINDSRKSSKARLSNTKSKSRTSPYPQYSGF------HTERSESDHESQWGGSPLTDTASP 415
BLAST of sim protein vs. Ensembl Xenopus
Match: f5 (coagulation factor V (proaccelerin, labile factor) [Source:Xenbase;Acc:XB-GENE-987398]) HSP 1 Score: 502.286 bits (1292), Expect = 8.682e-168 Identity = 268/459 (58.39%), Postives = 328/459 (71.46%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCN-YSMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAP 1423
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ+ T+ P S S N +N S++ R+ N S S P P+ + + ++ + S H S T T +P
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRPSTLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQVTTK------------PPFSYTSSNPTINDSRKSSKARLSNTKSKSRTSPYPQYSGF------HTERSESDHESQWGGSPLTDTASP 415
BLAST of sim protein vs. Ensembl Xenopus
Match: nwd1 (NACHT and WD repeat domain containing 1 [Source:Xenbase;Acc:XB-GENE-985040]) HSP 1 Score: 464.151 bits (1193), Expect = 3.957e-153 Identity = 237/395 (60.00%), Postives = 293/395 (74.18%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITID---GNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIP-TC-TPLSSSN 1231
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFPDGLG+ W + D + KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ P + ++ +F NAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K+HSNMFMFRA+LDL+LIFLD++VA LTGYEPQDLIEKT Y +H CD+ H+R+SH H +L+KGQV TKYYR L++NGGW W+QSY TIVHNSRSSRPHC+VSVNYVL+DVE K+L L +Q+ ++ +P +C TP+++S
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPDGLGDAWGHPSRMGPLD---NVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHP----------HLLQGTFPT----CQGFMNAGLTCSGYKVIHCSGYLKIRQYM-LDISLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDVFHLRYSH----------------HLLLVKGQVTTKYYRLLSKNGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLEQV------TVSKVPFSCRTPMTTSQ 355
BLAST of sim protein vs. Ensembl Mouse
Match: Sim2 (single-minded family bHLH transcription factor 2 [Source:MGI Symbol;Acc:MGI:98307]) HSP 1 Score: 490.73 bits (1262), Expect = 1.743e-168 Identity = 244/374 (65.24%), Postives = 295/374 (78.88%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLG+ W D ++ KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ P + + QEYEIE+SF +R+KCVLAKRNAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K+HSNMFMFRA+LDL+LIFLD++V LTGYEPQDLIEKT Y +H CD H+R++H H +L+KGQV TKYYR L++ GGW W+QSY T+VHNSRSSRPHC+VSVNYVL+DVE K+L L DQ+ T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLD---SVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPP-----LHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYM-LDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAH----------------HLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVST 349
BLAST of sim protein vs. Ensembl Mouse
Match: Sim1 (single-minded family bHLH transcription factor 1 [Source:MGI Symbol;Acc:MGI:98306]) HSP 1 Score: 499.975 bits (1286), Expect = 4.085e-167 Identity = 255/394 (64.72%), Postives = 304/394 (77.16%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP S N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-TFSYTSSSTPTISDN 367
BLAST of sim protein vs. Ensembl Mouse
Match: Sim2 (single-minded family bHLH transcription factor 2 [Source:MGI Symbol;Acc:MGI:98307]) HSP 1 Score: 491.5 bits (1264), Expect = 3.757e-165 Identity = 244/374 (65.24%), Postives = 295/374 (78.88%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLG+ W D ++ KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ P + + QEYEIE+SF +R+KCVLAKRNAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K+HSNMFMFRA+LDL+LIFLD++V LTGYEPQDLIEKT Y +H CD H+R++H H +L+KGQV TKYYR L++ GGW W+QSY T+VHNSRSSRPHC+VSVNYVL+DVE K+L L DQ+ T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLD---SVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPP-----LHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYM-LDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAH----------------HLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVST 349
BLAST of sim protein vs. Ensembl Mouse
Match: Npas3 (neuronal PAS domain protein 3 [Source:MGI Symbol;Acc:MGI:1351610]) HSP 1 Score: 291.967 bits (746), Expect = 3.513e-86 Identity = 163/411 (39.66%), Postives = 235/411 (57.18%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHIS----NALFDGEN-----------TIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC----------------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAKLLPLP+AITSQLDKASIIRLT SYLKMR+ F + W+ + N G E LGS++LQ+L+GFVF + +GK +YISET S++LGLSQVELTG+S+F+Y+HP DH EM+ L P V + S + + +E+SF IR+K L KR + + GYKVIH +G L+++ ++ Q MGL+ V H+LPP + E+++ +MF+ R N+DL +I+ + +++ P D++ K Y FIH D+ +RHSH +L KGQ +TKYYR++ +NGG+ W+QS TI N++++ ++ VNY+LS+ E KD + Q+
Sbjct: 60 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRD-FANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAASSASSSSQSETPEPVETTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHL----------------DLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 453
BLAST of sim protein vs. Ensembl Mouse
Match: Npas3 (neuronal PAS domain protein 3 [Source:MGI Symbol;Acc:MGI:1351610]) HSP 1 Score: 289.271 bits (739), Expect = 1.901e-85 Identity = 161/413 (38.98%), Postives = 234/413 (56.66%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGE-----------------NTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC----------------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAKLLPLP+AITSQLDKASIIRLT SYLKMR+ F + W+ + + E LGS++LQ+L+GFVF + +GK +YISET S++LGLSQVELTG+S+F+Y+HP DH EM+ L P V + S + + +E+SF IR+K L KR + + GYKVIH +G L+++ ++ Q MGL+ V H+LPP + E+++ +MF+ R N+DL +I+ + +++ P D++ K Y FIH D+ +RHSH +L KGQ +TKYYR++ +NGG+ W+QS TI N++++ ++ VNY+LS+ E KD + Q+
Sbjct: 30 KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRD-FANQGDPPWNLRMEGPPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAASSASSSSQSETPEPVETTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHL----------------DLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 425
BLAST of sim protein vs. UniProt/SwissProt
Match: sp|A2T6X9|SIM1_PANTR (Single-minded homolog 1 OS=Pan troglodytes OX=9598 GN=SIM1 PE=3 SV=1) HSP 1 Score: 500.36 bits (1287), Expect = 2.201e-166 Identity = 254/394 (64.47%), Postives = 305/394 (77.41%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP + N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-AFSYTSSSTPTMTDN 367
BLAST of sim protein vs. UniProt/SwissProt
Match: sp|P81133|SIM1_HUMAN (Single-minded homolog 1 OS=Homo sapiens OX=9606 GN=SIM1 PE=1 SV=2) HSP 1 Score: 500.36 bits (1287), Expect = 2.701e-166 Identity = 254/394 (64.47%), Postives = 305/394 (77.41%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP + N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-AFSYTSSSTPTMTDN 367
BLAST of sim protein vs. UniProt/SwissProt
Match: sp|Q61045|SIM1_MOUSE (Single-minded homolog 1 OS=Mus musculus OX=10090 GN=Sim1 PE=1 SV=3) HSP 1 Score: 499.975 bits (1286), Expect = 2.857e-166 Identity = 255/394 (64.72%), Postives = 304/394 (77.16%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W + + D + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP S N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHTSRTSPLD---NVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-TFSYTSSSTPTISDN 367
BLAST of sim protein vs. UniProt/SwissProt
Match: sp|A1YFY6|SIM1_PANPA (Single-minded homolog 1 OS=Pan paniscus OX=9597 GN=SIM1 PE=3 SV=1) HSP 1 Score: 499.975 bits (1286), Expect = 3.854e-166 Identity = 255/395 (64.56%), Postives = 308/395 (77.97%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIW-HNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSN 1231
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W H+ ++ L + + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYEIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H CD H+R +H H +L+KGQV TKYYRFL ++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQI + + Y + TP + N
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLGEAWGHSSWTSPL----DNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKP-AFSYTSSSTPTMTDN 367
BLAST of sim protein vs. UniProt/SwissProt
Match: sp|Q61079|SIM2_MOUSE (Single-minded homolog 2 OS=Mus musculus OX=10090 GN=Sim2 PE=1 SV=1) HSP 1 Score: 491.5 bits (1264), Expect = 2.628e-164 Identity = 244/374 (65.24%), Postives = 295/374 (78.88%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG---NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLG+ W D ++ KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSI+EYIHP+DH+EM+++L+ P + + QEYEIE+SF +R+KCVLAKRNAGLT GYKVIHCSGYLK++ + +D + C Q +GL+AVG SLPPSA+TE+K+HSNMFMFRA+LDL+LIFLD++V LTGYEPQDLIEKT Y +H CD H+R++H H +L+KGQV TKYYR L++ GGW W+QSY T+VHNSRSSRPHC+VSVNYVL+DVE K+L L DQ+ T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLD---SVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPP-----LHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYM-LDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAH----------------HLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVST 349
BLAST of sim protein vs. TrEMBL
Match: U5YR84 (Sim protein (Fragment) OS=Schmidtea mediterranea OX=79327 GN=sim PE=2 SV=1) HSP 1 Score: 1233.78 bits (3191), Expect = 0.000e+0 Identity = 636/654 (97.25%), Postives = 638/654 (97.55%), Query Frame = 2
Query: 179 ASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARXXXXXXXXXXXXXXXXXXXXEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGVEIQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA 2140
ASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPSYQYSYYSQEYEIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQT +LMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARNSDYSQINSNSSESSFIRSSEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGV+IQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA
Sbjct: 1 ASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPSYQYSYYSQEYEIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQT----------------LLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARNSDYSQINSNSSESSFIRSSEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGVDIQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA 638
BLAST of sim protein vs. TrEMBL
Match: A0A2J7QQL4 (Single-minded-like protein 1 OS=Cryptotermes secundus OX=105785 GN=B7P43_G06091 PE=4 SV=1) HSP 1 Score: 528.094 bits (1359), Expect = 3.487e-178 Identity = 257/379 (67.81%), Postives = 312/379 (82.32%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVK--TIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSI 1192
MKEKSKNAAR+RREKENAEF+ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR+VFPDGLG+ W + + + KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+S+LS P + + S E+E+E++F +R+KCVLAKRNAGLT GGYKVIHCSGYLKVK ++ T + C+QN+GL+AVGHSLPPSA+TE+K+H NMFMFRA+LDL+LIFLD +VA LTGYEPQDLIEKT Y ++H CD++H+R SH H++L KGQV TKY+RFLT++GGW WMQSY TIVHNSRSSRPHC+VSVNYVLSD+EAKDL+L +Q+ TRE+ ++
Sbjct: 1 MKEKSKNAARSRREKENAEFLELAKLLPLPSAITSQLDKASIIRLTTSYLKMRHVFPDGLGDAWG--AAPPPVNPRESCIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTSVLSS-PQPLFQHGGHLQSHEFEVERAFFLRMKCVLAKRNAGLTTGGYKVIHCSGYLKVKQFSLDTAPYDSCLQNVGLVAVGHSLPPSAITEIKLHCNMFMFRASLDLKLIFLDARVAQLTGYEPQDLIEKTLYHYVHGCDMMHMRFSH----------------HTLLFKGQVTTKYFRFLTKDGGWVWMQSYATIVHNSRSSRPHCIVSVNYVLSDLEAKDLVLNEEQLGTREEVAM 360
BLAST of sim protein vs. TrEMBL
Match: A0A2J7QQN0 (Uncharacterized protein OS=Cryptotermes secundus OX=105785 GN=B7P43_G06091 PE=4 SV=1) HSP 1 Score: 528.094 bits (1359), Expect = 3.655e-178 Identity = 257/379 (67.81%), Postives = 312/379 (82.32%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVK--TIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSI 1192
MKEKSKNAAR+RREKENAEF+ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR+VFPDGLG+ W + + + KELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+S+LS P + + S E+E+E++F +R+KCVLAKRNAGLT GGYKVIHCSGYLKVK ++ T + C+QN+GL+AVGHSLPPSA+TE+K+H NMFMFRA+LDL+LIFLD +VA LTGYEPQDLIEKT Y ++H CD++H+R SH H++L KGQV TKY+RFLT++GGW WMQSY TIVHNSRSSRPHC+VSVNYVLSD+EAKDL+L +Q+ TRE+ ++
Sbjct: 1 MKEKSKNAARSRREKENAEFLELAKLLPLPSAITSQLDKASIIRLTTSYLKMRHVFPDGLGDAWG--AAPPPVNPRESCIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTSVLSS-PQPLFQHGGHLQSHEFEVERAFFLRMKCVLAKRNAGLTTGGYKVIHCSGYLKVKQFSLDTAPYDSCLQNVGLVAVGHSLPPSAITEIKLHCNMFMFRASLDLKLIFLDARVAQLTGYEPQDLIEKTLYHYVHGCDMMHMRFSH----------------HTLLFKGQVTTKYFRFLTKDGGWVWMQSYATIVHNSRSSRPHCIVSVNYVLSDLEAKDLVLNEEQLGTREEVAM 360
BLAST of sim protein vs. TrEMBL
Match: A0A1S3JVT4 (single-minded homolog 2 isoform X2 OS=Lingula unguis OX=7574 GN=LOC106176360 PE=4 SV=1) HSP 1 Score: 532.717 bits (1371), Expect = 5.297e-176 Identity = 259/385 (67.27%), Postives = 310/385 (80.52%), Query Frame = 2
Query: 56 DKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCL----PSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITID---GNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNS 1189
D MKEKSKNAAR RREKENAEF ELAKLLPLPSAITSQLDKASIIRL++SYLKMR VFP+GLG+ W I +N +EK+LGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ P VP ++ IE++F +R+KCVLAKRNAGLT+GGYKVIHCSGYLK+K + T+D + C QN+GL+AVGHSLPPSA+TE+KM+SNMFMFRA+LDL+LIFLD +VA LTGYEPQDLIEKT Y +IH CDILH+R++H H++L+KGQV TKYYRFL ++GGW WMQSY TIVHNSRSSRPHC+VSVNYVLS+VEAKDL LQ +Q + + D S
Sbjct: 44 DDMKEKSKNAARTRREKENAEFYELAKLLPLPSAITSQLDKASIIRLSTSYLKMRTVFPEGLGDAWGRRIPP-----KNPLEKDLGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAILTFHQPYHPHMVPEFE---------IERAFFLRMKCVLAKRNAGLTSGGYKVIHCSGYLKIKQL-TLDIAPYDACYQNVGLVAVGHSLPPSAITEIKMYSNMFMFRASLDLKLIFLDARVARLTGYEPQDLIEKTMYHYIHACDILHMRYAH----------------HTLLLKGQVTTKYYRFLAKDGGWIWMQSYATIVHNSRSSRPHCIVSVNYVLSEVEAKDLQLQVEQTLNKNDAS 397
BLAST of sim protein vs. TrEMBL
Match: A0A1S3JV10 (single-minded homolog 2 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106176360 PE=4 SV=1) HSP 1 Score: 532.332 bits (1370), Expect = 9.747e-176 Identity = 259/385 (67.27%), Postives = 310/385 (80.52%), Query Frame = 2
Query: 56 DKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCL----PSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITID---GNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNS 1189
D MKEKSKNAAR RREKENAEF ELAKLLPLPSAITSQLDKASIIRL++SYLKMR VFP+GLG+ W I +N +EK+LGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ P VP ++ IE++F +R+KCVLAKRNAGLT+GGYKVIHCSGYLK+K + T+D + C QN+GL+AVGHSLPPSA+TE+KM+SNMFMFRA+LDL+LIFLD +VA LTGYEPQDLIEKT Y +IH CDILH+R++H H++L+KGQV TKYYRFL ++GGW WMQSY TIVHNSRSSRPHC+VSVNYVLS+VEAKDL LQ +Q + + D S
Sbjct: 51 DDMKEKSKNAARTRREKENAEFYELAKLLPLPSAITSQLDKASIIRLSTSYLKMRTVFPEGLGDAWGRRIPP-----KNPLEKDLGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAILTFHQPYHPHMVPEFE---------IERAFFLRMKCVLAKRNAGLTSGGYKVIHCSGYLKIKQL-TLDIAPYDACYQNVGLVAVGHSLPPSAITEIKMYSNMFMFRASLDLKLIFLDARVARLTGYEPQDLIEKTMYHYIHACDILHMRYAH----------------HTLLLKGQVTTKYYRFLAKDGGWIWMQSYATIVHNSRSSRPHCIVSVNYVLSEVEAKDLQLQVEQTLNKNDAS 404
BLAST of sim protein vs. Ensembl Cavefish
Match: sim1a (SIM bHLH transcription factor 1 [Source:NCBI gene;Acc:103042487]) HSP 1 Score: 498.819 bits (1283), Expect = 8.061e-167 Identity = 250/375 (66.67%), Postives = 299/375 (79.73%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAAR RREKEN+EF ELAKLLPLPSAITSQLDKASIIRLT+SYLKMR VFP+GLGE W H+S A + + +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ +S++ QEYE+E+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + DG C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H+CD H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K L L DQ +
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESW-GHVSRA--SSLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT-----AHQPYHSHFVQEYEMERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDTFHLRCAH----------------HLLLVKGQVTTKYYRFLAKEGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQATS 349
BLAST of sim protein vs. Ensembl Cavefish
Match: SIM2 (SIM bHLH transcription factor 2 [Source:NCBI gene;Acc:103031815]) HSP 1 Score: 495.738 bits (1275), Expect = 1.369e-165 Identity = 244/374 (65.24%), Postives = 291/374 (77.81%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTII--TIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTR 1177
MKEKSKNAA+ RREKEN EF ELAKLLPLPSAITSQLDKASIIRLT+SYL+MR VFPDGLGE W + D + KELGS+LLQTL+GFVF++A+DGKIMYISETASVHLGLSQVELTGNSIFEYIHP+DH+EM+++LS P + Y +E+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + C Q +GL+AVGHSLPPS +TE+K+HSNMFMFRA+LDL+LIFLD++VA LTGYEPQDLIEKT YQ +H CD+ H+R++H H +L+KGQV TKYYR L+++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+DVE K++ L Q R
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLRMRAVFPDGLGEAWGQQSRISPLD---NMAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIFEYIHPSDHDEMTAVLSAHQPLHPHFLPEYE-----MERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYVMDVCLYESCYQIVGLVAVGHSLPPSGITEIKLHSNMFMFRASLDLKLIFLDSRVAELTGYEPQDLIEKTLYQHVHGCDVFHLRYAH----------------HLLLVKGQVTTKYYRMLSKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVEYKEMQLSQGQNRPR 350
BLAST of sim protein vs. Ensembl Cavefish
Match: npas1 (neuronal PAS domain protein 1 [Source:ZFIN;Acc:ZDB-GENE-060503-934]) HSP 1 Score: 281.952 bits (720), Expect = 7.482e-84 Identity = 157/393 (39.95%), Postives = 223/393 (56.74%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENT--------------IEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLP-------------------------SAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQN-MGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVL 1123
KEKS+NAAR+RR KEN EF ELAK+LPLP AITSQLDKAS+IRLT SYL MR+ G W + L +GEN E+ LG++LLQ+L+GFVF+++ +G+ +YISET S++LGLSQVELTG+S+F+YIHPADH EM+ L P S + E+ F IR+K L KR + + GYKVIH +G ++ + + ++ + MGL+A+ H+LPPS + E++M S MF+FR N+DL++ + + ++ P +++ T Y FIH D+ +R SH+ L KGQV+T YYR+L R GG+ W+QS T+ N ++ V+ VNY+L
Sbjct: 37 KEKSRNAARSRRGKENFEFFELAKMLPLPGAITSQLDKASVIRLTISYLHMRHFASQG-DPPW-----SPLMEGENNCNKRRSSHSLATDIFEQHLGAHLLQSLDGFVFVVSQEGRFLYISETVSIYLGLSQVELTGSSVFDYIHPADHVEMAERLGIKPHLRAEAGCQTTQESISSSASTSSLAGTPEPPSSPLSSGDELAERGFFIRMKSTLTKRGLHVKSSGYKVIHVTGRIRCRPALVPGSSRSLHRPMGLVALAHTLPPSTLNEVRMESQMFVFRVNMDLQVTYCEN-ISEYMDLSPAEVVGHTCYHFIHVEDLDTIRQSHED-----------------LRKGQVVTGYYRWLQRRGGYLWVQSCATVSINHKAPHERNVIWVNYIL 405
BLAST of sim protein vs. Ensembl Cavefish
Match: NPAS3 (neuronal PAS domain protein 3 [Source:HGNC Symbol;Acc:HGNC:19311]) HSP 1 Score: 259.61 bits (662), Expect = 7.381e-75 Identity = 158/404 (39.11%), Postives = 227/404 (56.19%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFD-----------------GENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETA-SVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAK+LPLP AITSQLDKASIIRLT SYLKMR+ F + W+ I + E LGS++LQ+L+GFVF + +G+ +YISETA +V + L QVELTG+S+F+Y LLS P V S S+ S + +E+SF IR+K L KR + + GYKVIH +G L+++ +T + + Q MG++ V H+LPP + E+++ MF+ R N+DL +++ + +++ P D+I K Y FIH D+ +RHSH MN KGQ +TKYYR++ +NGG+ W+QS TI N++++ ++ VNYVLS+ E KD + Q+
Sbjct: 12 KEKSRDAARSRRGKENFEFYELAKMLPLPGAITSQLDKASIIRLTISYLKMRD-FANQGDPPWNLRIEGPPPNTSVKAIGSQRRRSPSSIASEIFEPHLGSHILQSLDGFVFALNKEGRFLYISETAFNVSVCL-QVELTGSSVFDYQLGMKLPPGRGLLSQGGGAEDGASSASSSSHSETPEPVESSSPSHLSPDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRIRMALTHNRSVPNQIMGMVVVAHALPPPTINEVRIDCQMFVTRVNMDLNIVYCENRISDYMDLTPVDIIGKRCYHFIHAEDVEGIRHSHLD--LMN--------------KGQCVTKYYRWIQKNGGYIWIQSSATIAINAKNANEKNIIWVNYVLSNPEYKDTPMDIAQL 397
BLAST of sim protein vs. Ensembl Cavefish
Match: hif1ab (hypoxia-inducible factor 1-alpha-like [Source:NCBI gene;Acc:103033873]) HSP 1 Score: 251.906 bits (642), Expect = 1.399e-72 Identity = 132/383 (34.46%), Postives = 216/383 (56.40%), Query Frame = 2
Query: 41 KNQSTDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRN--AGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMG---LIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
K S+++ KEKS++AAR RR KE+ F ELA LPLP +TS LDKASI+RLT SYL+MR + G E E+ +E +L + L+ LEGF+ +++ DG ++Y+SE +GL+Q +LTG+S+F++ HP DHEEM +L S ++E E+SF +R+KC L R + + +KV+HC+G+++V+ + + L+ + +P + E+ + S F+ R LD++ + D ++ L G+EP DL+ ++ Y++ H D H+ +H H++ KGQ T YR L + GG+ W+++ T+++N ++S+P C+V VNYVLS + D+IL +Q +T
Sbjct: 10 KRVSSERRKEKSRDAARCRRGKESEVFFELANQLPLPHNVTSHLDKASIMRLTISYLRMRKLLSSGDAE------------KESELESQLNGFYLKALEGFLMVLSEDGDMVYLSENVCKCMGLTQFDLTGHSVFDFAHPCDHEEMREMLV-------HRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRVQESGEGSADSSFREPPITYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNRSVYEYYHALDSDHLTKTH----------------HNLFAKGQATTGQYRMLAKKGGYVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDMILSLEQTVT 357
BLAST of sim protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010678.1 (pep scaffold:Pmarinus_7.0:GL476879:218132:256610:1 gene:ENSPMAG00000009669.1 transcript:ENSPMAT00000010678.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 264.618 bits (675), Expect = 6.034e-77 Identity = 154/434 (35.48%), Postives = 235/434 (54.15%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIW-------------------HNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC-LPS--AVPXXXXXXXXX----------------------------XXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT-----------IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVL--SDVEAKDLILQTDQIMTR 1177
KEKS++AAR+RR KEN EF EL K+LPLP AIT QLDKAS++RLT S+L+MR+ G W H I L E+ LGS +LQ+L+GFVF + DG+ +YISET S++LGLSQVE+ G+S FEY+HPAD E++ L LPS PS ++ +++SF IR+K L KR + + GYKVIH G L+V+ + DG +Q +GL+A+ H+LPP ++E+++ +MF+ R +L+LR+++ + +V+ + ++L+ K+ Y FIH D+ +R SH +L KGQ +T+Y R+L + GG+ W+QS T+ N++++ V+ ++Y+L S+ E KDL++ Q+ R
Sbjct: 24 KEKSRDAARSRRGKENLEFYELGKMLPLPGAITGQLDKASLVRLTISHLRMRDFAAHG-DPPWEPSRECSPPGTAAKGMGNQHGQIPKEL--ATEVFEEHLGSQILQSLDGFVFTLNFDGRFLYISETVSIYLGLSQVEMAGSSAFEYVHPADRGELAEQLGMKLPSGPGTPSQSALGAAEDAASTASSSSQADGLDPAELSSPPLINVSEGLDRSFFIRMKSTLTKRGLHVKSSGYKVIHVVGRLRVRAASSSAGGTSLGLAGDDGGASVQLLGLVALAHALPPPTLSEIRIDCHMFVTRVSLELRILYCENRVSDYLDFAAEELVGKSCYHFIHPGDVEGIRLSHL----------------DLLNKGQCVTRYVRWLQKGGGYVWVQSSATVNINTKNANEKTVIWISYILSNSNTEHKDLLMDLQQLPHR 438
BLAST of sim protein vs. Ensembl Sea Lamprey
Match: npas1 (neuronal PAS domain protein 1 [Source:ZFIN;Acc:ZDB-GENE-060503-934]) HSP 1 Score: 231.106 bits (588), Expect = 2.446e-65 Identity = 141/412 (34.22%), Postives = 213/412 (51.70%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHIS----NALFDGEN-------------TIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC---------------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAK+LPLP AITSQLDKASIIRLT SYLKMR+ G WH H+ N G++ T E + +LQ+L+GFVF++ DG+ +YISET S++LGLSQVE+ G+S F+Y+HPADH E++ L P + + + + + +SF IR+K L KR + + GYKV + + + + ++ +GL+ V + P E + N+ + + ++ +++ P DL+ ++ Y FIH D+ +R +H +L KGQ +TKYYR++ ++GG+ W+QS TI N+++ +V +NYVLSD E KD + Q+
Sbjct: 6 KEKSRDAARSRRGKENFEFYELAKMLPLPGAITSQLDKASIIRLTISYLKMRDFAAHG-DPPWHLHMDGPPPNTSVKGKHAQACRRRTSLFFITFVAECLARVLQSLDGFVFVLNFDGRFLYISETVSIYLGLSQVEMAGSSAFDYVHPADHSELAEQLGMKLPPGRNASLQAAAEDGASSASSSQAETPEPMEPTTPTMLNPDESLNRSFFIRMKSTLTKRGVHIKSSGYKVRGLGERARAEESVLENEGVWLRTLGLLFVSRWVEPENFGE---YCNIVLTYCAMLWSILECHFRISDYMDLAPADLVGRSCYHFIHAEDVEGIRQNHI----------------DMLNKGQCVTKYYRWMQKSGGYVWIQSSATIAINTKNINEKTIVWINYVLSDPEYKDCPMDVQQL 397
BLAST of sim protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010244.1 (pep scaffold:Pmarinus_7.0:GL476338:404399:422645:-1 gene:ENSPMAG00000009272.1 transcript:ENSPMAT00000010244.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 227.639 bits (579), Expect = 4.501e-64 Identity = 135/397 (34.01%), Postives = 216/397 (54.41%), Query Frame = 2
Query: 44 NQSTDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFP-DGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRN--AGLTNGGYKVIHCSGYLKV------KTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTK-VASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLIL---QTDQIMTREDNSIG 1195
N ++++ KEKS+NAAR RR KE F ELA+ LPLP ++++ LDKAS++R S+L+MR + DG E HI + ++ L+ LEGF ++ DG I+Y+S+ S +LG + V+L G SIF++ HP DHEE+ +LSC VP + ++E E F +R+KC + R L + +KV++CSG+ KV + G + L+ + +P A E + S+ F+ R LD++ + D + V L GY P++L+ K+ Y++ H D ++ SH HS+ KGQ T YR L ++GG+ W+Q+ ++++NSRS++P VV ++YVLS VE I QT+++ +D + G
Sbjct: 10 NATSERRKEKSRNAARCRRSKETEVFCELARELPLPQSVSASLDKASVMRFAISFLRMRKLLASDGSTE----HIDSM---------GDIDPAFLKVLEGFFLVMNHDGDIVYLSDNVSKYLGTTHVDLVGQSIFDFTHPCDHEEIKEILSC--KQVP-LGSAKKNKETPTEIDFLMRMKCTITNRGRTVNLKSASWKVLNCSGHQKVCGSSSSTQTESSHGFKDPAQTYLVLICQPIPHPAELEAPLDSHTFLSRHTLDMKFSYCDDRFVVDLIGYCPEELLGKSVYEYYHALDSDNITKSH----------------HSLFSKGQAKTGQYRMLAKHGGYVWVQTQASVIYNSRSAQPQSVVCIHYVLSGVEENTTIFSLEQTERLFKLQDTAQG 374
BLAST of sim protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000148.1 (pep scaffold:Pmarinus_7.0:GL476394:228933:277938:1 gene:ENSPMAG00000000126.1 transcript:ENSPMAT00000000148.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 182.956 bits (463), Expect = 4.884e-49 Identity = 121/395 (30.63%), Postives = 199/395 (50.38%), Query Frame = 2
Query: 53 TDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRN--AGLTNGGYKVIHCSGYLKV-KTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTF------YQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLIL---QTDQIMTREDNSIGYI 1201
+++ KEKS++AAR RR E F ELA LPLP ++TS LDKASI+RL SYL+MR ++ HN A+ + ++E+ S + LEGFV + +G ++++S+ + +GL+QV+L G+SIF+++HP D EE+ +L Y+ + E +R+KC L R L + +KV+HCSG++K+ + G + + L+ + PP+ + + F+ N ++ + T +LI F F T H H+H H+V KGQ +T YR L + GG+ W+++ T++++SR+S+P CVV VNYVLS + D I QT+++ ++G +
Sbjct: 12 SERRKEKSRDAARCRRSNETEVFYELANELPLPHSVTSHLDKASIMRLAISYLRMR--------KLLHN---GAVVE---DCQEEMDSLFGKALEGFVMALTEEGDMVFLSDGVNKCVGLAQVDLMGHSIFDFVHPCDQEEVREML--------VYRQGASVKAPPSEVCQXMRMKCTLTNRGRTVNLKSASWKVLHCSGHMKLYEGSAASAGGKRARXQVLLLMKSRTPPARRANQQSALDFQTFQ-NPHVKFMVHACCTECTT-----ELILMLFENLPEELHFSATPTTGHTAHAHPL----------VCSSHAVFTKGQAVTGQYRILAKGGGYAWVETQATVIYSSRNSQPQCVVCVNYVLSGIVENDTIFSLEQTERLFKPNKAAVGQV 368
BLAST of sim protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010232.1 (pep scaffold:Pmarinus_7.0:GL476593:142358:168129:1 gene:ENSPMAG00000009263.1 transcript:ENSPMAT00000010232.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 109.383 bits (272), Expect = 1.698e-26 Identity = 57/157 (36.31%), Postives = 93/157 (59.24%), Query Frame = 2
Query: 701 MGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDT-KVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
+GL+AV H+LPP ++E+++ +MF+ + NL+LR+ + ++ +++ D++ K+ Y IHT D+ +R SH ++ KGQ IT YYR+L + GG+ W+QS TI NS+++ VVSVNYVLS++E K IL Q+
Sbjct: 145 LGLVAVAHALPPPTLSEVRIDCHMFVTKLNLELRVSYCESSRISDYMDQTASDIVGKSCYHLIHTEDVAALRLSHL----------------DLINKGQCITNYYRWLQKCGGYIWVQSTATITINSKNADEKTVVSVNYVLSNLEMKGCILDLQQM 285
BLAST of sim protein vs. Ensembl Nematostella
Match: EDO45858 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRN4]) HSP 1 Score: 244.973 bits (624), Expect = 6.668e-75 Identity = 133/361 (36.84%), Postives = 212/361 (58.73%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGE-----IWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKR--NAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLS 1126
K KS++AAR+RR ++N EF EL+ LPLP +I+SQLD+ I+RLT+SY+K++ + + + N ++LFD + LLQ L+GFV++IA DG+ +YISE + +LGLSQ+E+TGNS+++Y+HP DHEE+++ L V S + KSF +R+K L R N L Y+V+HC+G +K KTII +G + + L+A+ L + E+ + F R LD++ + D +V+SL GY +++I K++Y F H D+ +V ++H+ +L KGQ ++KYYRF+ R GGW W+Q+ +V++S++ +P V +NYVL
Sbjct: 15 KCKSRDAARSRRGQQNDEFAELSHQLPLPKSISSQLDRLCIMRLTNSYIKIKRLLSTMMNQDVPNVYALNFQESSLFDKQ----------LLQALDGFVYVIAQDGQCLYISENVTYYLGLSQIEVTGNSLYKYVHPCDHEELANQLGAGSKRVDSSDHY---------KSFFLRMKSTLTSRGKNVNLRASTYRVVHCTGSMKYKTIINKEGQEQKVPLFLVAIAVPLMFATTFEVPLDRGTFTSRHMLDMKFLQCDDRVSSLLGYTREEMIGKSWYSFHHAADLDNVLNTHKM----------------LLTKGQSVSKYYRFMVRGGGWVWLQTKANVVYDSKTCQPQFVFCINYVLG 340
BLAST of sim protein vs. Ensembl Nematostella
Match: EDO43785 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXJ5]) HSP 1 Score: 226.868 bits (577), Expect = 2.827e-68 Identity = 134/371 (36.12%), Postives = 203/371 (54.72%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDG-----ENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLL---SCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLT-NGGYK---------VIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVL 1123
KE+S++AARNRR KENA+F ELA+LLPLP+AITSQLDKASI+RLT SYL MR N DG E TI Y ++GF+ +++ +GKI+YISET SV+LGLSQVELTGN+++ Y+HP D ++++ L L + PS + KSF +R+KC L +R T + G+K VIHC G LK + N+ + V S+ + E+ + NMF+ R N+DL++++ + ++ Y +D++ + Y F H D+ ++ H L KGQ++TKYYR++ +NGGW WMQ+ +++ + + ++ +NY+L
Sbjct: 4 KERSRDAARNRRGKENAQFDELARLLPLPAAITSQLDKASIVRLTISYLSMREF------------AGNCNTDGSSSSKEGTIN-HTQCYYTNAMDGFLMVLSQEGKILYISETVSVNLGLSQVELTGNNVYHYVHPEDQTDLANQLYEIEILANNSPSPTDT---------KSFFMRMKCTLVRRGGSYTKSSGFKACLAKKTKCVIHCVGRLKKYAL----DNESTHRKAFVMVCQSVMSMNINELPLECNMFVSRVNMDLKIVYCEGRIHKFMDYFAKDIVGISAYDFYHAGDVAVIQGHHA----------------KFLAKGQIMTKYYRWMNKNGGWVWMQTKCSLIPHPSNPELKQMLCLNYIL 332
BLAST of sim protein vs. Ensembl Nematostella
Match: EDO37467 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFT2]) HSP 1 Score: 102.834 bits (255), Expect = 1.210e-23 Identity = 87/373 (23.32%), Postives = 156/373 (41.82%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLK-MRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLI-AADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLK-----------CVLAKRN-------------AGLTNGGYKVIHCSGYLK-------VKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSN---------MFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQS 1054
++E R RR K NA EL+ ++P + + + DK +++R+ +Y+K +R P + N+ + L D +EL +L+ +GF+F++ ++Y+S++ S L SQ +++ IHP D E++ LS S P + +++ L C + + N + Y V+HC+GYLK + G L+ +G P S HSN F+ R +LD + F+D +V + GY+P+D++ + Y F H D+ H+ S Y + +KGQ ++ YRF ++ G W W+++
Sbjct: 9 LRENHSEIERRRRNKMNAYINELSDMVPSCTGLARKPDKLTVLRMAVNYMKTLRGTAPQDV-----NYKPSFLSD------QELKHLILEAADGFLFVVNCQTATVVYVSDSISPVLNQSQNAWMNQCLYDLIHPEDVEKVRDQLS--SSNSPDAGRVLDIKTGSVKRDAHGALSRMYSSTRRNFICRMRRGNEVCETQVKEEHPKVPVLEDEYAVVHCTGYLKNWSGSSSSNGNSSFQGED-PNGTSLVTIGRLQPASVP-----HSNDLAETPTVTEFISRHSLDGKFTFVDQRVTEVLGYQPRDMLGQLCYDFFHPDDLEHMMES---------------YDQVMKLKGQTLSVRYRFRSKTGDWVWLRT 347
BLAST of sim protein vs. Ensembl Nematostella
Match: EDO32631 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SUG4]) HSP 1 Score: 102.834 bits (255), Expect = 1.267e-23 Identity = 92/391 (23.53%), Postives = 174/391 (44.50%), Query Frame = 2
Query: 89 RNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAAD-GKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSA---------------VPXXXXXXXXXXXXIEKSFSIRLKCVLA--------------------KRNAGLTNGGYKVIHCSGYLKV-----KTIITIDGNQCIQNMG-LIAVGHSLPPS-AMTEMKMH--SNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLS 1126
+ RR+K N EL+ ++P+ +A++ +LDK +++R+ + MR + + N+ L D ++L + +L+ +GF+F++ D G+I+Y+S++ L LSQ++L GNS ++ +HP D + LS L P + + +SF R+KC + K A + ++H +GYLK + D + +N+ L+AVG + S MT+ + F R + D + I++D ++ S+ GY PQ++I + Y + H D+ V SH++ ++G+ YRFL ++G + +++ T+ N + +V N VL+
Sbjct: 11 KRRRDKMNTYINELSTMIPMCNAMSRKLDKLTVLRMAVQH--MRALRGRAVPFTETNYKPAFLSD------EDLKNLVLEAADGFLFVVGCDRGRILYVSDSIQNSLYLSQLDLVGNSFYDQVHPRDVATIKDQLSSLEGTPKERQAQEAAKNINISPKIETNKGQMCSGARRSFFCRMKCGVKIKKSKADDSDSTPEPCIMNRKSKAKQVTTTFFLVHFTGYLKSWPPTGGSEDEEDEDNDARNLSCLVAVGRLVEVSDEMTDFSRPDVAKQFTSRHSSDGKFIYVDQRIVSICGYLPQEVIGTSGYDYFHPEDLEIVAQSHKS-----------------ALQGETAVSSYRFLCKSGHYIPLRTRSTLFRNPWTKEIEFLVCTNDVLT 376
BLAST of sim protein vs. Ensembl Nematostella
Match: EDO44747 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUS9]) HSP 1 Score: 98.5969 bits (244), Expect = 3.079e-23 Identity = 73/267 (27.34%), Postives = 125/267 (46.82%), Query Frame = 2
Query: 101 EKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDI 901
++ N E LAKLLP P + +LDK SI+RL++SYL+ +N F K L LL L+GFV ++ D ++ Y SET +LGLSQ + +IH DHE ++ L P+ E++F R+KC+L T+ G+ ++ +K+ + + ++ + LI +++ E+++ +++F + +DL + +D K SL GY +D+ ++ Y IH DI
Sbjct: 1 DRFNIELDNLAKLLPFPHDVIQKLDKLSILRLSASYLRAKNFF------------------------KVLMHPLL-ALDGFVIVLTQDFELFYASETIQTYLGLSQASVIHQDFLRFIHVDDHEMITKYLQ------PNSVEQSSESALSAERTFVCRMKCILN------TSAGFFKVYIFR-IKILDMTLPESDKREYGLFLICTPMETMTNSILEIRLKTSLFCTKNRMDLSFMDIDQKGRSLLGYHKRDIALQSSYCMIHFDDI 229
BLAST of sim protein vs. Ensembl Medaka
Match: ENSORLT00000040145.1 (SIM bHLH transcription factor 2 [Source:NCBI gene;Acc:101169554]) HSP 1 Score: 501.13 bits (1289), Expect = 9.799e-169 Identity = 248/373 (66.49%), Postives = 299/373 (80.16%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG--NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLP+AITSQLDKASIIRLTSSYLKMR VFP+GLG+ W S+ D ++ K+LG++LLQTL+GFVF++A+DGKI+YISETASVHLGLSQVELTGNSIFEY+HP+DH+EM+++L CL Q ++S E+EIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + C Q +GL+AVGHSLPPS +TE+K+HSNMFMFRA+LDL+LIFLD KVA LTGYEPQDLIEKT Y +HTCD+ H+R++H H +L+KGQV TKYYR L+++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+DVE K+L L DQI T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPAAITSQLDKASIIRLTSSYLKMRAVFPEGLGDGWGETSSSCSLD---SVAKDLGAHLLQTLDGFVFVVASDGKIIYISETASVHLGLSQVELTGNSIFEYVHPSDHDEMTTVL-CLGKP----QRHHFSHEFEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKLRQYVMDMALYESCYQTVGLVAVGHSLPPSGITEIKLHSNMFMFRASLDLKLIFLDMKVAELTGYEPQDLIEKTLYHHVHTCDVFHLRYAH----------------HLLLVKGQVTTKYYRLLSKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVECKELQLSRDQIRT 349
BLAST of sim protein vs. Ensembl Medaka
Match: ENSORLT00000006805.2 (SIM bHLH transcription factor 2 [Source:NCBI gene;Acc:101169554]) HSP 1 Score: 501.13 bits (1289), Expect = 9.799e-169 Identity = 248/373 (66.49%), Postives = 299/373 (80.16%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDG--NQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMT 1174
MKEKSKNAA+ RREKEN EF ELAKLLPLP+AITSQLDKASIIRLTSSYLKMR VFP+GLG+ W S+ D ++ K+LG++LLQTL+GFVF++A+DGKI+YISETASVHLGLSQVELTGNSIFEY+HP+DH+EM+++L CL Q ++S E+EIE+SF +R+KCVLAKRNAGLT GGYKVIHCSGYLK++ + C Q +GL+AVGHSLPPS +TE+K+HSNMFMFRA+LDL+LIFLD KVA LTGYEPQDLIEKT Y +HTCD+ H+R++H H +L+KGQV TKYYR L+++GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+DVE K+L L DQI T
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPAAITSQLDKASIIRLTSSYLKMRAVFPEGLGDGWGETSSSCSLD---SVAKDLGAHLLQTLDGFVFVVASDGKIIYISETASVHLGLSQVELTGNSIFEYVHPSDHDEMTTVL-CLGKP----QRHHFSHEFEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLKLRQYVMDMALYESCYQTVGLVAVGHSLPPSGITEIKLHSNMFMFRASLDLKLIFLDMKVAELTGYEPQDLIEKTLYHHVHTCDVFHLRYAH----------------HLLLVKGQVTTKYYRLLSKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDVECKELQLSRDQIRT 349
BLAST of sim protein vs. Ensembl Medaka
Match: sim1b (SIM bHLH transcription factor 1 [Source:NCBI gene;Acc:101160454]) HSP 1 Score: 493.812 bits (1270), Expect = 8.105e-165 Identity = 246/374 (65.78%), Postives = 295/374 (78.88%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXX-XXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKT----IITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
MKEKSK AAR RREKEN+EF ELAK+LPLPSAITSQLDKASIIRLT+SYLKMR VFP GLGE W + D I +ELGS+LLQTL+GF+F++A DGKIMYISETASVHLGLSQVELTGNSI+EYIHPADH+EM+++L+ P + + QEYE+E+SF +R+KCVLAKRNAGLT+GGYKVIHCSGYLK++ + +G C QN+GL+AVGHSLPPSA+TE+K+HSNMFMFRA+LD++LIFLD++VA LTGYEPQDLIEKT Y +H+CDI H+R +H H +L+KGQV TKYYRFL + GGW W+QSY TIVHNSRSSRPHC+VSVNYVL+D E K + L DQ+
Sbjct: 1 MKEKSKTAARTRREKENSEFYELAKMLPLPSAITSQLDKASIIRLTTSYLKMRIVFPQGLGEAWGHSSRTRTLD---NIGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLT------PHQPFHSHFVQEYEVERSFFLRMKCVLAKRNAGLTSGGYKVIHCSGYLKIRQYSLDMSPFEG--CYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDIFHLRCAH----------------HLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGMQLSLDQM 347
BLAST of sim protein vs. Ensembl Medaka
Match: NPAS3 (neuronal PAS domain protein 3 [Source:NCBI gene;Acc:101175039]) HSP 1 Score: 291.967 bits (746), Expect = 3.342e-86 Identity = 162/415 (39.04%), Postives = 234/415 (56.39%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFD-----------------GENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSC------------------------------LPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
KEKS++AAR+RR KEN EF ELAK+LPLP AITSQLDKASIIRLT SYLKMR+ F + W+ I + E LGS++LQ+L+GFVF + +G+ +YISET S++LGLSQVELTG+S+F+YIHP DH EM+ L P V S S + + +E+SF IR+K L KR + + GYKVIH +G L+++ +T + Q MG++ V H+LPP + E+++ MF+ R N+DL++++ + +++ P +++ K YQFIH D+ +R SH +L KGQ +TKYYR++ +NGG+ W+QS TI N+++S ++ VNYVLS+ E KD + Q+
Sbjct: 19 KEKSRDAARSRRGKENFEFYELAKMLPLPGAITSQLDKASIIRLTISYLKMRD-FANQGDPPWNLRIEGPPPNTSVKAIGSQRRRSPSAVASEIFEPHLGSHILQSLDGFVFALNKEGRFLYISETVSIYLGLSQVELTGSSVFDYIHPGDHVEMAEQLGMKLPPGRGMSLSQAAINEDGASSASSSSHSETPEPVESSSPSLLAPDNSLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRIRMALTHSRSVPNQIMGMVVVAHALPPPTINEVRIDCQMFVTRVNMDLKIVYCENRISDYMDLTPVEIVGKRCYQFIHAEDVEGIRQSHL----------------DLLNKGQCVTKYYRWIQKNGGYIWIQSSATIAVNTKNSSEKNIIWVNYVLSNPEYKDTPIDISQL 416
BLAST of sim protein vs. Ensembl Medaka
Match: hif1aa (hypoxia inducible factor 1 subunit alpha [Source:NCBI gene;Acc:101158737]) HSP 1 Score: 243.047 bits (619), Expect = 1.277e-69 Identity = 128/381 (33.60%), Postives = 221/381 (58.01%), Query Frame = 2
Query: 41 KNQSTDKMKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRN--AGLTNGGYKVIHCSGYLKVKTIIT---IDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQI 1168
K S+++ KEKS++AAR+RR KE+ F ELAKLLPLP ++S LDKAS++RLT SYL+MR + G E E ++ + S ++ L+GF+ +++ DG ++Y+SE + LGL+Q +LTG+++F+Y HP D EE+ +L S ++E E+SF +R+KC L R + + +KV+HCSG + V ++ +G + L+ + +P + E+ + + F+ R +D++ + D ++ L GY+P+DL+ ++ Y++ H D H+ +HQ ++ KGQV T YR L ++GG+ W+++ T+++N+++S+P CVV VN+VLS ++ + LI+ +QI
Sbjct: 10 KRVSSERRKEKSRDAARSRRGKESEVFYELAKLLPLPHNVSSSLDKASVMRLTISYLRMRKLL--GTDEPKQEE--------ETELDMKFNSSYMKALDGFLMVLSEDGDMIYLSENVNKCLGLAQFDLTGHNVFDYTHPCDQEELREMLV-------YRTGSKKAKEPNPERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGRVHVNSVEAEQNSNGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLMNRSVYEYYHALDSDHLTKTHQ----------------NLFAKGQVCTGRYRMLAKSGGFVWVETQATVIYNTKNSQPQCVVCVNFVLSGIQEEKLIMSLEQI 357
BLAST of sim protein vs. Planmine SMEST
Match: SMESG000031846.1 (SMESG000031846.1) HSP 1 Score: 1311.59 bits (3393), Expect = 0.000e+0 Identity = 675/693 (97.40%), Postives = 676/693 (97.55%), Query Frame = 2
Query: 62 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYPIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARXXXXXXXXXXXXXXXXXXXXEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGVEIQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA 2140
MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPSYQYSYYSQEYEIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQT +LMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDY IPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARNSDYSQINSNSSESSFIRSSEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGVEIQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA
Sbjct: 1 MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPSYQYSYYSQEYEIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQT----------------LLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDLILQTDQIMTREDNSIGYIPTCTPLSSSNSINVDLNISQQPLYNRMCNYSMSSDYQIPRRTKYKIRPNKQSKNNNSQHPYSLPNSASTPTTAPVARNSDYSQINSNSSESSFIRSSEKTELFAQKVNQLPTDENQYPISNSSVSDNKPFLNDNSDTIGDKSIITYHQDQLASSYSKISTESIFNTGMYNSSFAFLDSSMYNYNSTGSINDLSRRIPEHLWNKFVRPNFYYPLVNSNSDNSNLYINPDKISTEINNKLYDNGVEIQSGMPPFADKSVLIDSNMHTFDSKIDLSVNYYQQNVSNFNPNTDRRVDPLRFSVIQNPKDYCYNVMTA 677
BLAST of sim protein vs. Planmine SMEST
Match: SMESG000070743.1 (SMESG000070743.1) HSP 1 Score: 125.561 bits (314), Expect = 1.215e-29 Identity = 92/371 (24.80%), Postives = 172/371 (46.36%), Query Frame = 2
Query: 80 NAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVFPDGLGE--IWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVPXXXXXXXXXXXXIE------KSFSIRLKCVLAKRNAGLT---NGGYKVIHCSGYLKVKTIITIDGNQCIQNMGLIAV----GHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIEKTFYQFIHTCDILHVRHSHQTRMFMNEFYLEFFYFHSVLMKGQVITKYYRFLTRNGGWKWMQSYITIVHNSRSSRPHCVVSVNYVLSDVEAKDL 1147
N ++ RE+ N+E LA LLP ++ S+LDK SI+RL SYL+M+ F + I N + + L+ + G LQ L GFVF+++ DG++ S+T +LG Q ++ S+ E IH D EE LS P + + +IE + F++R +C+L + +T NG + +H + ++ + ++ + +GL A+ GH LP + + F + +LDL L+ +D + GY +++ + Y +H D+ ++ H+ + G + +R+ ++ W W+QS + IV ++ + H +++ + L+ E ++L
Sbjct: 27 NPSKRHRERLNSELDHLASLLPFDQSVISKLDKLSILRLAVSYLRMKCYFQTVQNDRPISDNRLPSHLYHFPYDLNCTEGDAHLQALNGFVFIVSCDGEVFSASKTVEYYLGFHQSDILHQSVLELIHSEDREEFKRQLSWSSMLPPEKRNMSFRDIVKIENCQYLQRCFTVRFRCLLDNTSGFITLEINGRLQFLHGQPNITLEP----ETDKSLPPLGLFAICSPFGH-LPNLDAAQRDL---TFKTKHSLDLSLLAMDVRAKVTFGYCDKEISKLRTYNLVHQDDLNYLAKGHE----------------EIFKSGTIGLLVHRWKNKSQKWVWLQSSLKIVF--KAGKQHGIMATHRQLTQDEGREL 371
BLAST of sim protein vs. Planmine SMEST
Match: SMESG000047742.1 (SMESG000047742.1) HSP 1 Score: 114.39 bits (285), Expect = 2.524e-27 Identity = 90/302 (29.80%), Postives = 149/302 (49.34%), Query Frame = 2
Query: 65 KEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVF---------PDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPAD----HEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMG-LIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIE--KTFYQFIHTCDILHVRHSH 922
KEK ++AARNRR EN EF EL++LLPL I QLDKAS++RL SYLK+ N+F L EI + N +++ LQ+L+ + +++ I+YISE S LGLSQV++ G EY+H D H ++C K+ ++R+K L+KRNA L++ GY +++ + + Q +N G ++ + + P+ +TE+ + + + + ++ ++TK Y Q IE K+FY++IH ++ V++ H
Sbjct: 35 KEKCRDAARNRRGMENNEFSELSRLLPLHPEIAVQLDKASVVRLAVSYLKL-NLFLTENSISSSCRNLAEITNQKYRNLVYNSFQ---------WLQSLDEVMMVLSRKCNILYISENVSAILGLSQVDMAGCDFDEYLHSKDKDRFHLHFKESMTCDKP-----------------KNINVRVKSNLSKRNAILSSYGYGILNLN--------MCWIQRQSQKNKGAMVVLIQPILPAGVTEISIPHCCVVILVDYNFKVFHIETK----NIYTDQLKIETNKSFYEYIHPFNLNEVKNCH 297
BLAST of sim protein vs. Planmine SMEST
Match: SMESG000047742.1 (SMESG000047742.1) HSP 1 Score: 95.9005 bits (237), Expect = 1.808e-21 Identity = 81/288 (28.12%), Postives = 138/288 (47.92%), Query Frame = 2
Query: 107 ENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLKMRNVF---------PDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAADGKIMYISETASVHLGLSQVELTGNSIFEYIHPAD----HEEMSSLLSCLPSAVPXXXXXXXXXXXXIEKSFSIRLKCVLAKRNAGLTNGGYKVIHCSGYLKVKTIITIDGNQCIQNMG-LIAVGHSLPPSAMTEMKMHSNMFMFRANLDLRLIFLDTKVASLTGYEPQDLIE--KTFYQFIHTCDILHVRHSH 922
EN EF EL++LLPL I QLDKAS++RL SYLK+ N+F L EI + N +++ LQ+L+ + +++ I+YISE S LGLSQV++ G EY+H D H ++C K+ ++R+K L+KRNA L++ GY +++ + + Q +N G ++ + + P+ +TE+ + + + + ++ ++TK Y Q IE K+FY++IH ++ V++ H
Sbjct: 2 ENNEFSELSRLLPLHPEIAVQLDKASVVRLAVSYLKL-NLFLTENSISSSCRNLAEITNQKYRNLVYNSFQ---------WLQSLDEVMMVLSRKCNILYISENVSAILGLSQVDMAGCDFDEYLHSKDKDRFHLHFKESMTCDKP-----------------KNINVRVKSNLSKRNAILSSYGYGILNLN--------MCWIQRQSQKNKGAMVVLIQPILPAGVTEISIPHCCVVILVDYNFKVFHIETK----NIYTDQLKIETNKSFYEYIHPFNLNEVKNCH 250
BLAST of sim protein vs. Planmine SMEST
Match: SMESG000035153.1 (SMESG000035153.1) HSP 1 Score: 57.7658 bits (138), Expect = 2.632e-8 Identity = 37/144 (25.69%), Postives = 74/144 (51.39%), Query Frame = 2
Query: 89 RNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLK-MRNVFPDGLGEIWHNHISNALFDGENTIEKELGSYLLQTLEGFVFLIAA-DGKIMYISETASVHLGLSQVELTGNSIFEYIHPADHEEMSSLLSCLPSAVP 514
R RR K A EL ++P S++ + DK +I+R+ +++K +R G+ + + ++EL +L+ +GF+F+ DG+++Y+S++ + L +Q + +S+++ HP D E++ L C S P
Sbjct: 51 RRRRNKMTAYISELCDMVPTCSSLARKPDKLTILRMAVTHMKTLRGTGNTGV---------DGSYKPSFLSDQELKHLILEAADGFLFVCQCEDGRVVYVSDSVTAVLNQNQSDWYQHSLYDLCHPDDIEKIREQL-CPNSVSP 184 The following BLAST results are available for this feature:
BLAST of sim protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of sim protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of sim protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of sim protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of sim protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of sim protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of sim protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of sim protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021317 ID=SMED30021317|Name=sim protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2149bpback to top protein sequence of SMED30021317-orf-1 >SMED30021317-orf-1 ID=SMED30021317-orf-1|Name=SMED30021317-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=694bp MKEKSKNAARNRREKENAEFVELAKLLPLPSAITSQLDKASIIRLTSSYLback to top Aliases
The feature 'sim protein' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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