Leucine Rich repeat-containing domain protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021280 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Match: LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2 [Source:HGNC Symbol;Acc:HGNC:23443]) HSP 1 Score: 97.4413 bits (241), Expect = 2.145e-20 Identity = 87/366 (23.77%), Postives = 160/366 (43.72%), Query Frame = 1
Query: 250 VRKQFSLVCIEND-LITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFK--------NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKI-PSHKDNAID 1314
+ ++F V IEN L P+ +FIN + L L+ NNI +++ AL+ L L L+ NK+ + AF+ L+ L L+ N + + ++L+ L YLDLSSN + ++ +S FL+ ++ + EI + + LHDNPW CDCR+R +++ ++ T+ IL+N + ++C+ P + + LS KP+ + ++ +NVTL C ++ P + W +G+L H + L+ S+G + + + + +D G Y C +N++G +SN + + + P+ +A D
Sbjct: 53 LSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKI----DALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEI------------------------------------LSSLVVALHDNPWVCDCRLRGLVQFVKSI---------TLPVILVNSY-LICQGPLSKAGQLFHETELSACM-KPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDGLLGGKHLTPV-LTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIG--KSNLVISLHVQPAQALHAPD 364
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Match: LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2 [Source:HGNC Symbol;Acc:HGNC:23443]) HSP 1 Score: 94.3597 bits (233), Expect = 2.054e-19 Identity = 85/359 (23.68%), Postives = 155/359 (43.18%), Query Frame = 1
Query: 250 VRKQFSLVCIEND-LITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQ-LSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKI-PSHKDNAID 1314
+ ++F V IEN L P+ +FIN + L L+ NNI +++ AL+ L L L+ NK+ + AF+ L+ L L+ N + + ++L+ L YLDLSSN + ++ +S FL+ ++ + EI + + LHDNPW CDCR+R +++ ++ T+ IL+N + ++C+ P + + LS KP+ + ++ +NVTL C ++ P + W W L+ S+G + + + + +D G Y C +N++G +SN + + + P+ +A D
Sbjct: 53 LSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKI----DALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEI------------------------------------LSSLVVALHDNPWVCDCRLRGLVQFVKSI---------TLPVILVNSY-LICQGPLSKAGQLFHETELSACM-KPQISTPSANITIRAGQNVTLRCLAQASPSPSIAW----TYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIG--KSNLVISLHVQPAQALHAPD 354
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Match: LRRC24 (leucine rich repeat containing 24 [Source:HGNC Symbol;Acc:HGNC:28947]) HSP 1 Score: 83.1889 bits (204), Expect = 5.678e-16 Identity = 81/340 (23.82%), Postives = 136/340 (40.00%), Query Frame = 1
Query: 316 INKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHL-ENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQ-----------------SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
I L L NNI L AL L L L +N + + AF+ + +L L+L +N L S F L +L L L+ N + + + FL L L+EL+L+E E+ + L L+ L+ L L +NPW CDC + W W + + L ++ + + +C P L + L D+ S C P ++ + + +L E++ ++CQ +P+ V W K + Q R + SG +++N+T+ + G Y CE +N G+AR + L++
Sbjct: 48 IPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRL----RGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQ---PLASLQVLRLTENPWRCDCALHWLGAW---IKEGGQRLLTSRDRKI------MCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRK---VPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHA------GKYECEASNAGGAARVPFRLLV 362
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Match: LRFN5 (leucine rich repeat and fibronectin type III domain containing 5 [Source:HGNC Symbol;Acc:HGNC:20360]) HSP 1 Score: 78.5666 bits (192), Expect = 1.327e-14 Identity = 95/349 (27.22%), Postives = 146/349 (41.83%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSA 1257
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEA 366
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Match: LRFN5 (leucine rich repeat and fibronectin type III domain containing 5 [Source:HGNC Symbol;Acc:HGNC:20360]) HSP 1 Score: 78.5666 bits (192), Expect = 1.333e-14 Identity = 95/349 (27.22%), Postives = 146/349 (41.83%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSA 1257
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEA 366
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Celegans
Match: lron-2 (ELRR (Extracellular Leucine-Rich Repeat) ONly [Source:UniProtKB/TrEMBL;Acc:Q23580]) HSP 1 Score: 55.0694 bits (131), Expect = 1.813e-7 Identity = 40/135 (29.63%), Postives = 69/135 (51.11%), Query Frame = 1
Query: 283 NDLITFPKSNFINK--DIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKG 681
N L + P S +N+ + L+L N+I + ALD F L +L+L+ N I I AF+ L++L + N ++ +FRY+ +L+ L + PI +IP + F+ + NL L + E + I++G
Sbjct: 196 NSLTSIPSSALVNQRNTLTNLNLGLNSINEVPVGALD-FPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKF----PSWAPEMFRYITQLKTLGIGETPISVIPNNAFMHIPNLIRLEMSEAAVDT-IERG 324
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Celegans
Match: lron-2 (ELRR (Extracellular Leucine-Rich Repeat) ONly [Source:UniProtKB/TrEMBL;Acc:Q23580]) HSP 1 Score: 55.0694 bits (131), Expect = 1.813e-7 Identity = 40/135 (29.63%), Postives = 69/135 (51.11%), Query Frame = 1
Query: 283 NDLITFPKSNFINK--DIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKG 681
N L + P S +N+ + L+L N+I + ALD F L +L+L+ N I I AF+ L++L + N ++ +FRY+ +L+ L + PI +IP + F+ + NL L + E + I++G
Sbjct: 196 NSLTSIPSSALVNQRNTLTNLNLGLNSINEVPVGALD-FPVLSSLSLEFNGITVIPPQAFQGVPNLQFLYMTGNKF----PSWAPEMFRYITQLKTLGIGETPISVIPNNAFMHIPNLIRLEMSEAAVDT-IERG 324
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Match: kek1 (gene:FBgn0015399 transcript:FBtr0346702) HSP 1 Score: 101.293 bits (251), Expect = 1.392e-21 Identity = 88/346 (25.43%), Postives = 148/346 (42.77%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDAL--DDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDH-----WDRIQ-LSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKI 1287
CI+ LI P+ I+ + +LD+S N ++ L + + NL L L + KI +I FK + L L L +N L+ T S ++ L L L+SN I I F + +L +L L + + L LP +E +L + LHDNPW CDCR+R K WL+ NI + P+ P+ + + DL + +F C+P+ L + + EN +++C+ + P + + W+ NG L+ ++ + RI L Q G + + ++ D + C N G A +N+TL + +
Sbjct: 107 CIDRHLIQIPE--HIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV----TVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIE---TLSRLHGIELHDNPWLCDCRLRDTKLWLMK------------RNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSM 431
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Match: kek1 (gene:FBgn0015399 transcript:FBtr0332210) HSP 1 Score: 101.293 bits (251), Expect = 1.392e-21 Identity = 88/346 (25.43%), Postives = 148/346 (42.77%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDAL--DDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDH-----WDRIQ-LSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKI 1287
CI+ LI P+ I+ + +LD+S N ++ L + + NL L L + KI +I FK + L L L +N L+ T S ++ L L L+SN I I F + +L +L L + + L LP +E +L + LHDNPW CDCR+R K WL+ NI + P+ P+ + + DL + +F C+P+ L + + EN +++C+ + P + + W+ NG L+ ++ + RI L Q G + + ++ D + C N G A +N+TL + +
Sbjct: 107 CIDRHLIQIPE--HIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV----TVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIE---TLSRLHGIELHDNPWLCDCRLRDTKLWLMK------------RNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSM 431
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Match: kek3 (gene:FBgn0028370 transcript:FBtr0300848) HSP 1 Score: 79.7221 bits (195), Expect = 6.095e-15 Identity = 87/359 (24.23%), Postives = 138/359 (38.44%), Query Frame = 1
Query: 265 SLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFE--NLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEE-MMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILI----------QDHWDRIQLSQSSGRNYV-------ANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
S++C+ +L P+ ++ +LDLS N I+++ +D+ + NL + L + I +AF+ L L L N L + S ++ L L LS NPI +P+ F + L +L L + + I ++ A L + L L L N W C C +R + W++ +NI I P CE+P L + L + F C P+ + T N+T+SC E P+ VKW LI D R + + YV +NLTI ++ D G Y C N G ++ TL +
Sbjct: 93 SVLCLNANLTHIPQP--LDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLL----SAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTIT---SLASLHGLELARNTWNCSCSLRPLRAWMLQ------------QNIPSGIPPT-CESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADM-QDAGIYTCAAENKAGKVEASVTLAV 428
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Match: kek3 (gene:FBgn0028370 transcript:FBtr0080752) HSP 1 Score: 79.7221 bits (195), Expect = 6.095e-15 Identity = 87/359 (24.23%), Postives = 138/359 (38.44%), Query Frame = 1
Query: 265 SLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFE--NLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEE-MMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILI----------QDHWDRIQLSQSSGRNYV-------ANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
S++C+ +L P+ ++ +LDLS N I+++ +D+ + NL + L + I +AF+ L L L N L + S ++ L L LS NPI +P+ F + L +L L + + I ++ A L + L L L N W C C +R + W++ +NI I P CE+P L + L + F C P+ + T N+T+SC E P+ VKW LI D R + + YV +NLTI ++ D G Y C N G ++ TL +
Sbjct: 93 SVLCLNANLTHIPQP--LDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLL----SAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTIT---SLASLHGLELARNTWNCSCSLRPLRAWMLQ------------QNIPSGIPPT-CESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADM-QDAGIYTCAAENKAGKVEASVTLAV 428
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Match: kek5 (gene:FBgn0031016 transcript:FBtr0074707) HSP 1 Score: 75.0998 bits (183), Expect = 1.775e-13 Identity = 72/323 (22.29%), Postives = 123/323 (38.08%), Query Frame = 1
Query: 337 LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRI-------QLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
LDLS N IR L+ E L N+ +++N+I + N+ F N S L + RNN RL + L + + L +L + L + KE F+++Q L L L N W C C ++ F+ + I+ LY+ P C+ P L+ K ++P F C+P+ L ++ + + +N++L C+ P+ V W N +Q + R+ Q+ + + + L I + D G Y C N G A + + L++
Sbjct: 128 LDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIEFRNN------------------RLRQVQLH-----VFAGTMALSAISLEQNRLSHLHKET---------------------------------FKDLQKLMHLSLQGNAWNCSCELQDFRDFAIS-----KRLYTP---------PTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIEANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRAS-DKGAYTCVADNRGGRAEAEFQLLV 379
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Match: lrrc24 (leucine rich repeat containing 24 [Source:ZFIN;Acc:ZDB-GENE-060503-496]) HSP 1 Score: 84.7297 bits (208), Expect = 1.697e-16 Identity = 73/264 (27.65%), Postives = 116/264 (43.94%), Query Frame = 1
Query: 316 INKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKT-LVVKHLENVTLSCQFESFPKSYVKWFK 1104
I + + L N I + + L D L L L +N I + AF++ L L+L N + + + VFR L L L L+ N I + + F L+ L+EL+L+E + E+ + L N P L+ + L+ L + DNPW CDC + W + W +N+ L S+ E MLC P L L ++P + C P ++L + L V+ E++ +SCQ +P+ V W K
Sbjct: 28 ITQGTQTIFLQDNAIGQIRQRDLSDLGQLHYLYLQNNSISTLEPGAFRSLGLLLELALNGNRI----HLITADVFRGLDHLRILYLAGNQINRLEDYTFRGLQRLQELHLQENVLEVLGDQALVGLSSLALLDLSRNNLRTLSPASLK---PLVSLQVLRVTDNPWRCDCALHWLRGW---INEEGQRLLSSAERR------MLCAEPPRLSHLSLVEVPPNSLVCIPPVVQLEPSHLTVRLGESLRVSCQASGYPQPQVTWRK 275
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Match: lrrc4ba (leucine rich repeat containing 4Ba [Source:ZFIN;Acc:ZDB-GENE-080327-25]) HSP 1 Score: 79.7221 bits (195), Expect = 6.513e-15 Identity = 104/364 (28.57%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L NL+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L
Sbjct: 100 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMSV-IERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVL 441
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Match: lrrc4ba (leucine rich repeat containing 4Ba [Source:ZFIN;Acc:ZDB-GENE-080327-25]) HSP 1 Score: 79.7221 bits (195), Expect = 6.513e-15 Identity = 104/364 (28.57%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L NL+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L
Sbjct: 100 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMSV-IERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVL 441
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Match: lrrc4ba (leucine rich repeat containing 4Ba [Source:ZFIN;Acc:ZDB-GENE-080327-25]) HSP 1 Score: 79.337 bits (194), Expect = 8.386e-15 Identity = 104/364 (28.57%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L NL+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L
Sbjct: 93 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMSV-IERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVL 434
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Match: lrrc4ba (leucine rich repeat containing 4Ba [Source:ZFIN;Acc:ZDB-GENE-080327-25]) HSP 1 Score: 79.337 bits (194), Expect = 8.386e-15 Identity = 104/364 (28.57%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L NL+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L
Sbjct: 93 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMSV-IERNAFDDLKNLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVL 434
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Match: ENSXETT00000026364.1 (leucine rich repeat and Ig domain containing 3 [Source:NCBI gene;Acc:100497438]) HSP 1 Score: 80.1073 bits (196), Expect = 7.152e-15 Identity = 94/340 (27.65%), Postives = 141/340 (41.47%), Query Frame = 1
Query: 301 PKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWK-ITNNAFKNKSKLKYLSLRNNALIISNNTFL-SSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYL-EEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEM-QLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLP----LSKFECKPKTLRLGKT--LVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYG--IDDGCYVCETTNNVGSARSNYTLIIK 1284
P+S + + +L L I L E NL L L+S + + + N AF+ L+L + ++ +N T + S+ R ++ LEYL+LS NPI II F DL L EL++ + + Q L +S L E FQ + LETL + DNP ACDCR+ W + TLN +N H +C +P +Q L D P F C+ +R K + + V+ C+ + P + W R+ S+S GR+ V +Y D G Y+C TN G+ TL +K
Sbjct: 196 PESLSYLQGLEVLRLRYLGINSLEEQNFQKLYNLKELELESWPLLEDVCNTAFQG------LNLTSLSITYTNLTSVPSAALRNMVYLEYLNLSFNPIRIIQRGAFKDLVRLLELHIVGAFLSTVESQAFLGLRQIRLLNVSNNLLATLE-----ESAFQSVNTLETLRVDDNPLACDCRLLWILQRRKTLNFDN--------------HQPVCASPAKIQGNALRDFPDSILFEHFTCQKPKIRDRKLQHITAHEGQPVSFHCRADGEPVPLIVWV-------SPQRRMITSRSVGRSTVLPEGTLEIRYAQVQDSGTYICIATNAGGNDTYFATLTVK 503 HSP 2 Score: 60.8474 bits (146), Expect = 6.735e-9 Identity = 53/156 (33.97%), Postives = 73/156 (46.79%), Query Frame = 1
Query: 178 FSTMKFLFLMEFS--LILKGYFLFDCVRKQFSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLREL 639
FS + FL L+ + +L DC Q S++C L T P+ I + +LDLSKN IR L + L + L N I I AF N L+ L L+ N L + + VF L L LD+S N I I+ + F DLR+L+ L
Sbjct: 11 FSIVVFLLLLLYPEWKVLGCPARCDCTPNQRSVICHRKRLTTIPEG--IPSETRLLDLSKNRIRCLNPGDFSPYSLLEEVDLSENIISTIEPGAFANLFFLQILKLKGNQLKL----IPTGVFTKLSNLTLLDISENKIVILLDFMFQDLRSLKSL 160
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Match: LRRC4C (leucine rich repeat containing 4C [Source:NCBI gene;Acc:100188921]) HSP 1 Score: 72.7886 bits (177), Expect = 1.224e-12 Identity = 98/366 (26.78%), Postives = 151/366 (41.26%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLS-SVFRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIR-IQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWD---RIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + +L LS+N+IR + A + NL L L N++ I N AF+ SKLK L LRNN + IS F S +YL ++L+ LDLS N + ++ F L +L++L++ M +I+ I++ AF +L +L L+LA NN LP+ L +Q + LH NPW C+C + W WL + + C TP L+ + +L + F C P + L V L C+ S +YV W I H RI + N+ N+T+ D G Y C +N+ G+ ++ TL
Sbjct: 100 RHLEVLQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEMKRLSYISEGAFEGLSNLKYLNLGMCNLRDIPNLTPLVKLDELDLSGNHLSVLRPGSFQGLTHLQKLWI--MHSQIQVIERNAFDDLQSLVELNLAHNNLTLLPHDLFTPLHNLQ--RIQLHHNPWNCNCDILWLSWWLKEIVTTGSTCCAR------------CSTPPSLKGTHIAELDHNYFTCYAPVIVEPPADLNVTEGMAAELKCR-ASTSLTYVSWITPNGTIMTHGSYKVRISVLNDGTLNF-TNVTVR------DTGLYTCIVSNSAGNTTASATL 441
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Match: LINGO2 (leucine rich repeat and Ig domain containing 2 [Source:NCBI gene;Acc:100490134]) HSP 1 Score: 70.4774 bits (171), Expect = 5.823e-12 Identity = 95/339 (28.02%), Postives = 133/339 (39.23%), Query Frame = 1
Query: 337 LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLR---------NNALIISNNTFLS-----------SVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPML--------CETPDYLQRK--KLCDLPLSK--FECKPKTLRLGKTLVVKHLEN--VTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYG--IDDGCYVCETTN 1242
L L K N+ + DAL NL +L L I + AFK LK L + N+L N TFLS ++LI L +L+LS NPIGII F DL L+EL+L + ++R + L N L E FQ + LE L + DNP CDCR+ W +L HPML C +PD L+ K+ D + F CK +R + L V E V ++C + P+ + W + + L +S+GR V +Y D G Y+C +N
Sbjct: 186 LTLEKCNLTAVPTDALSHLHNLYSLHLKYLNINVLPPFAFKRLFHLKILEISYWPLLDLVPANSLYGLNLTFLSITNTNLSTIPYHALKHLIYLTHLNLSYNPIGIIDTGVFSDLVRLQELHL--VGAQLRTIEPHAFQGLRFLRLLNVSQNLLE--TLEENAFQSPKALEVLCIDDNPLVCDCRLIW----------------------MLQRHPMLHFGGQQPMCSSPDSLKESSYKVLDAAVLSFYFTCKKPKIRDREMLQVHVDEGQRVQMNCNADGDPQPMISW------VTPRRRTVSL-KSNGRTTVLGNGTLEIRYAQIQDTGTYICVASN 491
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Match: LRIG2 (leucine-rich repeats and immunoglobulin like domains 2 [Source:NCBI gene;Acc:100494845]) HSP 1 Score: 70.0922 bits (170), Expect = 1.023e-11 Identity = 89/325 (27.38%), Postives = 137/325 (42.15%), Query Frame = 1
Query: 337 LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--IISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIE----NILLNIHPMLCETPDYLQRKKLCD-LPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFES---FPKSYVKWFKNGILIQD---------HWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGS 1254
LDLS N + L + A +L + L N+I I FK + L L LRNN + I ++ + VF L RL L L N I I F L +L+ L L + +Q E F M+L+ L+L+ + CDC+++WF W LN N H + + N L P+ + D+ +CD P + + +P+T T+ +K + NV+L+C S P S W K+G ++ D H I+L + Y+ L +F+ + D+G Y C TN+ GS
Sbjct: 219 LDLSYNQLNRLDDFAFVGLSSLEKINLGDNRINHIAEGVFKGLANLLVLDLRNNEISWAIEDS---NEVFAGLSRLHTLILQGNKIKSITMKAFTGLDSLQHLDLSNNAI-LSVQ---------------------------ENGFSFMKLQELILNTSNLLCDCQLKWFPHW---LNDNGFHQFVNVSCAHPNWLAGRSPLSVDAEDF-----ICDNFPKPQIKLQPET-----TVALKGM-NVSLTCAAASSSDTPMS-TAWRKDGEVLYDAEVENFARYHKHGIELIE-----YITVLHLFNVNF-TDEGKYQCVITNHFGS 491
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Match: LRIG2 (leucine-rich repeats and immunoglobulin like domains 2 [Source:NCBI gene;Acc:100494845]) HSP 1 Score: 70.0922 bits (170), Expect = 1.190e-11 Identity = 89/325 (27.38%), Postives = 137/325 (42.15%), Query Frame = 1
Query: 337 LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--IISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIE----NILLNIHPMLCETPDYLQRKKLCD-LPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFES---FPKSYVKWFKNGILIQD---------HWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGS 1254
LDLS N + L + A +L + L N+I I FK + L L LRNN + I ++ + VF L RL L L N I I F L +L+ L L + +Q E F M+L+ L+L+ + CDC+++WF W LN N H + + N L P+ + D+ +CD P + + +P+T T+ +K + NV+L+C S P S W K+G ++ D H I+L + Y+ L +F+ + D+G Y C TN+ GS
Sbjct: 240 LDLSYNQLNRLDDFAFVGLSSLEKINLGDNRINHIAEGVFKGLANLLVLDLRNNEISWAIEDS---NEVFAGLSRLHTLILQGNKIKSITMKAFTGLDSLQHLDLSNNAI-LSVQ---------------------------ENGFSFMKLQELILNTSNLLCDCQLKWFPHW---LNDNGFHQFVNVSCAHPNWLAGRSPLSVDAEDF-----ICDNFPKPQIKLQPET-----TVALKGM-NVSLTCAAASSSDTPMS-TAWRKDGEVLYDAEVENFARYHKHGIELIE-----YITVLHLFNVNF-TDEGKYQCVITNHFGS 512
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Match: Lrfn5 (leucine rich repeat and fibronectin type III domain containing 5 [Source:MGI Symbol;Acc:MGI:2144814]) HSP 1 Score: 77.7962 bits (190), Expect = 3.312e-14 Identity = 97/357 (27.17%), Postives = 148/357 (41.46%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A L I
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEATQTVDLHI 374
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Match: Lrfn5 (leucine rich repeat and fibronectin type III domain containing 5 [Source:MGI Symbol;Acc:MGI:2144814]) HSP 1 Score: 77.411 bits (189), Expect = 3.793e-14 Identity = 97/357 (27.17%), Postives = 148/357 (41.46%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A L I
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEATQTVDLHI 374
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Match: Lrrc4c (leucine rich repeat containing 4C [Source:MGI Symbol;Acc:MGI:2442636]) HSP 1 Score: 75.485 bits (184), Expect = 1.330e-13 Identity = 100/364 (27.47%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLS-SVFRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LS+N+IR + A + NL L L N++ I N AF SKLK L LRNN + IS F S RYL I+L+ LDLS N + I F L +L++L++ + ++ I++ AF NL +L ++LA NN LP+ L LE + LH NPW C+C + W W+ + +N + C TP L+ + + +L + F C P + L V L C+ S + V W NG ++ +++++ S G N+T+ D G Y C +N+VG+ ++ TL
Sbjct: 100 RHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQV-IERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLH--HLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCAR------------CNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCR-ASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQ------DTGMYTCMVSNSVGNTTASATL 441
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Match: Lrrc4c (leucine rich repeat containing 4C [Source:MGI Symbol;Acc:MGI:2442636]) HSP 1 Score: 75.485 bits (184), Expect = 1.330e-13 Identity = 100/364 (27.47%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLS-SVFRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LS+N+IR + A + NL L L N++ I N AF SKLK L LRNN + IS F S RYL I+L+ LDLS N + I F L +L++L++ + ++ I++ AF NL +L ++LA NN LP+ L LE + LH NPW C+C + W W+ + +N + C TP L+ + + +L + F C P + L V L C+ S + V W NG ++ +++++ S G N+T+ D G Y C +N+VG+ ++ TL
Sbjct: 100 RHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQV-IERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLH--HLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCAR------------CNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCR-ASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQ------DTGMYTCMVSNSVGNTTASATL 441
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Match: Lrrc4c (leucine rich repeat containing 4C [Source:MGI Symbol;Acc:MGI:2442636]) HSP 1 Score: 75.485 bits (184), Expect = 1.330e-13 Identity = 100/364 (27.47%), Postives = 155/364 (42.58%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLS-SVFRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTL 1275
+ + IL LS+N+IR + A + NL L L N++ I N AF SKLK L LRNN + IS F S RYL I+L+ LDLS N + I F L +L++L++ + ++ I++ AF NL +L ++LA NN LP+ L LE + LH NPW C+C + W W+ + +N + C TP L+ + + +L + F C P + L V L C+ S + V W NG ++ +++++ S G N+T+ D G Y C +N+VG+ ++ TL
Sbjct: 100 RHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQV-IERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLH--HLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCAR------------CNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCR-ASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQ------DTGMYTCMVSNSVGNTTASATL 441
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Match: sp|A6NDA9|LRIT2_HUMAN (Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LRIT2 PE=2 SV=1) HSP 1 Score: 94.3597 bits (233), Expect = 9.862e-19 Identity = 85/359 (23.68%), Postives = 155/359 (43.18%), Query Frame = 1
Query: 250 VRKQFSLVCIEND-LITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQ-LSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKI-PSHKDNAID 1314
+ ++F V IEN L P+ +FIN + L L+ NNI +++ AL+ L L L+ NK+ + AF+ L+ L L+ N + + ++L+ L YLDLSSN + ++ +S FL+ ++ + EI + + LHDNPW CDCR+R +++ ++ T+ IL+N + ++C+ P + + LS KP+ + ++ +NVTL C ++ P + W W L+ S+G + + + + +D G Y C +N++G +SN + + + P+ +A D
Sbjct: 53 LSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKI----DALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQKCRQPDCGAEI------------------------------------LSSLVVALHDNPWVCDCRLRGLVQFVKSI---------TLPVILVNSY-LICQGPLSKAGQLFHETELSACM-KPQISTPSANITIRAGQNVTLRCLAQASPSPSIAW----TYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIG--KSNLVISLHVQPAQALHAPD 354
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Match: sp|Q50LG9|LRC24_HUMAN (Leucine-rich repeat-containing protein 24 OS=Homo sapiens OX=9606 GN=LRRC24 PE=2 SV=2) HSP 1 Score: 83.1889 bits (204), Expect = 2.727e-15 Identity = 81/340 (23.82%), Postives = 136/340 (40.00%), Query Frame = 1
Query: 316 INKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHL-ENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQ-----------------SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
I L L NNI L AL L L L +N + + AF+ + +L L+L +N L S F L +L L L+ N + + + FL L L+EL+L+E E+ + L L+ L+ L L +NPW CDC + W W + + L ++ + + +C P L + L D+ S C P ++ + + +L E++ ++CQ +P+ V W K + Q R + SG +++N+T+ + G Y CE +N G+AR + L++
Sbjct: 48 IPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRL----RGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQ---PLASLQVLRLTENPWRCDCALHWLGAW---IKEGGQRLLTSRDRKI------MCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRK---VPQPREGRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHA------GKYECEASNAGGAARVPFRLLV 362
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Match: sp|Q96NI6|LRFN5_HUMAN (Leucine-rich repeat and fibronectin type-III domain-containing protein 5 OS=Homo sapiens OX=9606 GN=LRFN5 PE=1 SV=2) HSP 1 Score: 77.411 bits (189), Expect = 2.608e-13 Identity = 95/349 (27.22%), Postives = 146/349 (41.83%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSA 1257
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEA 366
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Match: sp|Q8BXA0|LRFN5_MOUSE (Leucine-rich repeat and fibronectin type-III domain-containing protein 5 OS=Mus musculus OX=10090 GN=Lrfn5 PE=1 SV=1) HSP 1 Score: 77.411 bits (189), Expect = 2.653e-13 Identity = 97/357 (27.17%), Postives = 148/357 (41.46%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A L I
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEATQTVDLHI 374
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Match: sp|D4A1J9|LRFN5_RAT (Leucine-rich repeat and fibronectin type-III domain-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Lrfn5 PE=1 SV=1) HSP 1 Score: 77.411 bits (189), Expect = 2.942e-13 Identity = 97/357 (27.17%), Postives = 148/357 (41.46%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLE-----------TLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFK-NGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
R+ L +N + + +F N + L LS+N I + A D NL L L+SN++ KITN+ F S L +L L NN L + ++T VF LE LDLS N + IP + +L L L+ M + I KG FS+L + L + N LP + FQ Q+ L NP C+C + W +R L++ +D +E C +P L + +P +F C+P + R + V + TL C+ P+ + W G LI + + N ++ I + K D G + C +N G A L I
Sbjct: 51 RRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVF----ALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMID-NIPKGTFSHLHKMTRLDVTSNKLQKLPP--DPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRR----LSREDD-----LET---------CASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYD-----NGTLDILITTVK---DTGAFTCIASNPAGEATQTMDLHI 374
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Match: A0A504Y3D3 (Putative slit OS=Fasciola gigantica OX=46835 GN=FGIG_05745 PE=4 SV=1) HSP 1 Score: 163.31 bits (412), Expect = 6.444e-38 Identity = 127/353 (35.98%), Postives = 180/353 (50.99%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSK-LKYLSLRNNALIISNN--TFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDL-RNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYE-FQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRL---------GKTLVVKHLE--NVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK 1284
C + LI P + IN+ LDLS N I +L+ED+ +L L L NKI+KIT AF ++ L YL LRNN I+SN+ +F + L+ L YLDLS NP+ I+P F + NL +L L + +++IQ GAF L L L+LA N+F N +E + Q L H W CDCR+ WF+RWL N+ + + L C +P + + L L L+ +C P+ L + + V L+ N+TLSC F S PK+ V W++NGILIQ HW R SSG + +L +D G Y C+T+N GSA N+ + +K
Sbjct: 37 CTHSRLIEVPGN--INRLTEELDLSHNLIEVLHEDSFHRLNSLRRLVLSHNKIYKITERAFLAVAQTLTYLDLRNNQ-IMSNSITSFPVTALAPLVHLTYLDLSGNPLSIVPTEFLRHMGANLTQLDLSSVPMKLQIQPGAFRGLAQLHRLNLAGNSFGEF-NEDSFEGLRPAQFSQLSFHGVQWRCDCRLLWFRRWL-----NHVPRKALFADALPGGE---CISPPAFKGRSLLFLNLTDLQCAPRLLGTIPPSQEQDSPEPVHVVALDGYNLTLSCVFVSEPKTQVHWYQNGILIQSHWKRFTQFTSSGTKFTTSLHFHQLNSQLDTGTYQCQTSNQKGSAGKNFMVDVK 377
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Match: A0A2H1CU83 (Leucine Rich repeat-containing domain protein OS=Fasciola hepatica OX=6192 GN=D915_02041 PE=4 SV=1) HSP 1 Score: 162.925 bits (411), Expect = 6.811e-38 Identity = 126/354 (35.59%), Postives = 178/354 (50.28%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSK-LKYLSLRNNALIISNNT-FLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDL-RNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYE-FQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLE-------------NVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK 1284
C + LI P + IN+ LDLS N I +L+ED+ +L L L NKI+KIT AF ++ L YL LRNN ++ ++ T F + L+ L YLDLS NP+ I+P F + NL +L L + +++IQ GAF L L L+LA N+F N +E + Q L LH W CDCR+ WF+RWL N+ + + L C +P + + L L L+ +C P+ L G + L+ N+TLSC F S PK V W++NGILIQ HW R SSG + +L +D G Y C+T+N GSA N+ + +K
Sbjct: 37 CTHSRLIEVPGN--INRLTEELDLSHNLIEVLHEDSFHRLNSLRRLVLSHNKIYKITERAFLAVAQTLTYLDLRNNQIMSNSITGFPITALAPLVHLTYLDLSGNPLSIVPTEFLQHMGANLTQLDLSSVPMKLQIQPGAFRGLAQLHRLNLAGNSFGEF-NEDSFEGLRPAQFSQLSLHGVQWRCDCRLLWFRRWL-----NHVPRKALFADALPGGE---CISPPAFKGRSLLFLNLTDLQCAPRLL--GTIPPSQELDSPEPVHVVALDGYNLTLSCVFVSEPKMQVHWYQNGILIQSHWKRFTQFTSSGTKFTTSLHFHQLNSQLDTGTYQCQTSNQKGSAGKNFMVDVK 377
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Match: A0A4E0RKD6 (Putative slit OS=Fasciola hepatica OX=6192 GN=D915_001401 PE=4 SV=1) HSP 1 Score: 163.31 bits (412), Expect = 7.648e-38 Identity = 126/354 (35.59%), Postives = 178/354 (50.28%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSK-LKYLSLRNNALIISNNT-FLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDL-RNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYE-FQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLE-------------NVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK 1284
C + LI P + IN+ LDLS N I +L+ED+ +L L L NKI+KIT AF ++ L YL LRNN ++ ++ T F + L+ L YLDLS NP+ I+P F + NL +L L + +++IQ GAF L L L+LA N+F N +E + Q L LH W CDCR+ WF+RWL N+ + + L C +P + + L L L+ +C P+ L G + L+ N+TLSC F S PK V W++NGILIQ HW R SSG + +L +D G Y C+T+N GSA N+ + +K
Sbjct: 37 CTHSRLIEVPGN--INRLTEELDLSHNLIEVLHEDSFHRLNSLRRLVLSHNKIYKITERAFLAVAQTLTYLDLRNNQIMSNSITGFPITALAPLVHLTYLDLSGNPLSIVPTEFLQHMGANLTQLDLSSVPMKLQIQPGAFRGLAQLHRLNLAGNSFGEF-NEDSFEGLRPAQFSQLSLHGVQWRCDCRLLWFRRWL-----NHVPRKALFADALPGGE---CISPPAFKGRSLLFLNLTDLQCAPRLL--GTIPPSQELDSPEPVHVVALDGYNLTLSCVFVSEPKMQVHWYQNGILIQSHWKRFTQFTSSGTKFTTSLHFHQLNSQLDTGTYQCQTSNQKGSAGKNFMVDVK 377
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Match: A0A3P6TYJ9 (Ig-like domain-containing protein OS=Dibothriocephalus latus OX=60516 GN=DILT_LOCUS2329 PE=4 SV=1) HSP 1 Score: 161.77 bits (408), Expect = 1.704e-37 Identity = 121/353 (34.28%), Postives = 175/353 (49.58%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKS-KLKYLSLRNNALI--ISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDL-RNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLV-------------VKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
CI ++L + P+ I+ D LDLS N I IL+ED+ F L L LD N+I+KIT+ AF+ + L+YLSLR N L +S+N F S L +L LDLS NP+G I + L LR L++ ++ + IQ AF+ L L+ L+ N F + P + +L + L W CDCR+ W + WL +++ Y + I P C+ P + L DLP++ F+C PK + T E + L C F S PK V W+KNG+L++ RI+ S G + LTIF +Y D G Y C T N+ GSAR+ + L +
Sbjct: 5 CINSELGSIPQG--IHPDTRKLDLSNNRIEILHEDSFLGFRQLQTLNLDDNRIYKITDRAFEALALTLEYLSLRRNRLSFRVSSN-FPVSALSKLKKLRGLDLSGNPLGRIATEWLSPLGETLRILHISDLNGPVEIQSNAFAGLGLLEDFDLSNNEFSAFPENAFEGIRPEKLTAINLTHISWVCDCRLLWLRHWLAQVHRQP---YVKEKKI---TSP--CKYPKEFSKLTLLDLPVTTFQCVPKLQAINATAANIYEQSKTFLHVSSAAGETIQLRCTFLSQPKMLVSWYKNGVLLRPELKRIRQETSKGTRFTTTLTIFDLQYDEDSGNYTCTTANSRGSARAAFQLWV 346
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Match: A0A0R3SAJ9 (Ig-like domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS1382 PE=4 SV=1) HSP 1 Score: 159.458 bits (402), Expect = 4.276e-37 Identity = 113/339 (33.33%), Postives = 176/339 (51.92%), Query Frame = 1
Query: 316 INKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKS-KLKYLSLRNNALII-SNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRN-LRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLEN--------------VTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
++ + ILDLS+N +++++ED+ ++ L L LD N+I+KIT+ A + S L+YLSLR N L + S++ F L L LDLS NP+G++ ++ L LR L L ++ ++ +++ AF L NL+ + N+F P + +L+ L L D PW CDC++ W ++WL + N TI C +P L + L LPL+ F+C P TL+ + H N +TL+C+F S PK V+W+KNG L++ R S S G + A LTI + D+G Y C+T+NN G AR ++L I
Sbjct: 54 VHPETRILDLSRNFLKVIHEDSFVEYHRLTQLILDYNEIYKITDRALNSISITLRYLSLRGNRLSVRSSSNFPIDALAKLRNLRILDLSENPLGVMVSNWLAPLGGTLRVLRLSGLIDQVELKENAFFGLGNLEEFDFSNNSFYHFPENAFSGIRPEKLKRLNLRDIPWHCDCKLFWLRQWLKEVKIINSPGEPTITGP--------CSSPPTLGKTPLISLPLTHFQCPP-TLQAMHSSAPHHFGNYKSLLYVTPSLGDSITLTCKFVSQPKMLVQWYKNGALLRPELKRFAQSVSRGSKFSAILTITDLRSPADNGNYTCKTSNNRGLARGVFSLNI 383
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Match: lrit2 (leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 [Source:NCBI gene;Acc:103045557]) HSP 1 Score: 80.4925 bits (197), Expect = 2.321e-15 Identity = 92/363 (25.34%), Postives = 151/363 (41.60%), Query Frame = 1
Query: 250 VRKQFSLVCIENDLIT-FPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLET------LLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRK-------KLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPS 1293
+ + F+ + IE +T PKS F K + L L+ N+I I+ +L NL L L+ NK+ + AF++ LK L L++N L + ++L L YLDLS N + +I + FL P Y + F+ + ET L LH+NPW CDCR+R F ++++L+ IL+N + + C P+Y+ K K C P++ ++ LG NVTL+C + P+ V W+ G+ I + +Q V + I S + D G Y C N +G+ S+ ++++ + S
Sbjct: 56 IPEDFTKIRIEKSHLTEIPKSAFSRYKSLENLWLNFNDITIINIKSLQGLNNLTELRLEGNKLSSVPWTAFEDAPSLKILDLKHNRL----DVLPEHALKFLPGLTYLDLSFNQLTVISKDVFLKW-----------------------------------------PLY-DRVFKSAERETVPTNVVLALHENPWQCDCRLRGFVEFVMSLSP---------PIILMNSY-LSCSGPEYMAGKFFHEVELKTCIKPVATSPTTNISMPLGA--------NVTLTCFAMARPEPAV-WWTYGLKILRGFHELQ--TRVNEETVKSELIIPSLHLADRGVYTCTANNFIGN--SSVSILVDVKS 349
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Match: lrrc4ba (leucine-rich repeat-containing protein 4B-like [Source:NCBI gene;Acc:103034410]) HSP 1 Score: 80.4925 bits (197), Expect = 3.014e-15 Identity = 105/378 (27.78%), Postives = 162/378 (42.86%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDY 1317
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L +L+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L + + D +++Y
Sbjct: 80 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMTV-IERNAFDDLKSLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVLNV---TAADASVNY 432
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Match: LRIT2 (leucine rich repeat, Ig-like and transmembrane domains 2 [Source:NCBI gene;Acc:103030533]) HSP 1 Score: 79.7221 bits (195), Expect = 4.311e-15 Identity = 86/337 (25.52%), Postives = 137/337 (40.65%), Query Frame = 1
Query: 262 FSLVCIENDLIT-FPKSNFINKDIAILD---LSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSS-GRNYVANLTIFSSKYGIDDGCYVCETTNNVGSA 1257
F + IEN +T P+ F ++ LD L+ N+I ++ +L+ NL L L NK+ + AF++ LK L L++N L + R+L L YLDLS N + +I FL+ R P ++ L LHDN W CDCR++ F ++ +++ IL+N + + C PD K +L L K KP+T + + NVTL C ++ P V+W + I+ +SQS G + + + I S + D G Y C N +G++
Sbjct: 16 FIKIRIENSHLTEIPQRAFFT--VSALDSLWLNFNDIALMNAKSLEGLNNLTELRLQGNKLRSVPWTAFQDAPNLKILDLKHNRL----DVLPEHALRHLPALTYLDLSFNQLKVISRDVFLNWPRYR-------------------------------------PQTHGRREEDAANVVLALHDNQWLCDCRLKGFVEFIKSVSP---------PIILMNSY-LTCSGPDSRAGKFFHELEL-KTCLKPQTSTPEVNITLPLGANVTLRCFVKARPDPVVQWSYSLKTIRG----FTVSQSQVGEDTIGSALIIPSVHVADRGLYTCTANNFIGNS 294
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Match: lrrc4ba (leucine-rich repeat-containing protein 4B-like [Source:NCBI gene;Acc:103034410]) HSP 1 Score: 79.7221 bits (195), Expect = 5.489e-15 Identity = 105/378 (27.78%), Postives = 162/378 (42.86%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDY 1317
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L +L+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L + + D +++Y
Sbjct: 93 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMTV-IERNAFDDLKSLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVLNV---TAADASVNY 445
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Match: lrrc4ba (leucine-rich repeat-containing protein 4B-like [Source:NCBI gene;Acc:103034410]) HSP 1 Score: 79.7221 bits (195), Expect = 5.489e-15 Identity = 105/378 (27.78%), Postives = 162/378 (42.86%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDY 1317
+ + IL LSKN IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS+ F+ + RYL +RLE L+LS N + II F L +LR+L+L + I++ AF +L +L+ L+L+ N+ SLP+ L Q +LE + L+ NPW C+C + W WL +N + C P YL+ K + +L S F C P + L V L C+ + S V W NG L+ R+++S G N+T+ D G Y C TN+ G+ + L + + D +++Y
Sbjct: 93 RHLEILQLSKNQIRQIEVGAFNGLPNLNTLELFDNRLTLVPSQAFEYLSKLRELWLRNNPIETLPGYAFHRVPSLRRLDLGELKKLDYISDAAFVGLINLRYLNLGMCGLKDIPNLTPLVRLEELELSGNRLEIIRPGSFQGLESLRKLWLMHSQMTV-IERNAFDDLKSLEELNLSHNSLHSLPHDLFTPLQ--KLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPYLKGKYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWITPNGTLMTHGSYRVRISVLHDGTLNFTNVTLR------DTGQYTCMVTNSAGNTTATAVLNV---TAADASVNY 445
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Match: lrrc4ba (leucine rich repeat containing 4Ba [Source:ZFIN;Acc:ZDB-GENE-080327-25]) HSP 1 Score: 81.2629 bits (199), Expect = 3.600e-16 Identity = 113/393 (28.75%), Postives = 166/393 (42.24%), Query Frame = 1
Query: 280 ENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLS-SVFRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIR-IQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLV-VKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDY 1317
EN L +F N + +L L++N IR + A + +L L L N++ I + AF+ SKL+ L LRNN + ISN F S RYL +RLE L+LS N I I+ F L NLR+L++ M E+R +++ AF L +LK L+LA N+ +SLP+ L Q +LE + LH NPW CDC + W WL NN + C P + L +L S+F C P + + + V + L C+ S S NG + +I++S G N+T+ D G Y C N+VG++ ++ TL + P N Y
Sbjct: 40 ENSLKMVQADSFRNLHRLEVLQLARNAIRQVEVGAFNGLTSLTTLELLDNRLTAIPSGAFEFLSKLRDLWLRNNPIEDISAYTFTRIPSLQRLDLGELTKLQFISNEAFEGLSNLRYLNLGMCNLREVPKLSPLVRLEELELSGNRIEILRPGSFQGLANLRKLWI--MHSEVRLVERNAFDELQSLKELNLAHNSLMSLPHDLFSPLQ--KLERVHLHHNPWTCDCDILWLSWWLRENVPNNATCCAR------------CALPADRKAINLWELDSSRFTCYPPLIEVPPSDVNISEGMAAELRCRAPSSASSVTWITPNGTSMTHGSYKIRISVLHDGTLNFTNVTV------QDTGIYTCLVANSVGNSTASATLNVTAPDTGTNGYTY 410
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Match: islr2 (immunoglobulin superfamily containing leucine-rich repeat 2 [Source:ZFIN;Acc:ZDB-GENE-050320-95]) HSP 1 Score: 77.7962 bits (190), Expect = 4.870e-15 Identity = 90/356 (25.28%), Postives = 142/356 (39.89%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLE-----NVTLSCQFESFPKSYVKW---FKNGILIQDHWDRIQLSQSS--GRNYVANLTIFSSKYGI---------DDGCYVCETTNNVG--SARSNYTL 1275
C L T PK + +I L LS N +R L DA ++ + +L L N++ I +L+ L L NN L F R L L+ L L++N + +P F L +LR L L + I++G F+ + L LLL++NP C C+ RW WL T + + + ENI C PD L+ + + +P EC T+RL + V+ V L CQ + P V W + G + +D ++ + + N V + + + + G ++G Y C TN++G SA + TL
Sbjct: 40 CAYKQLETVPKG--LPANITSLSLSANRLRSLSRDAFEEIPLMSSLWLSHNELVSIEKGTLAGLVQLRNLDLSNNQLA----DFSWEDLRNLTALQVLKLNNNNLVRLPRDAFETLTDLRSLRLHHNLFAT-IEEGT---------------------------FENLHALSHLLLYENPLRCSCKARWLPAWLNTTSID----IPSKENI-------ACAEPDELKGQAVQQMP--DVECVAPTVRLSSSPDVRETRLYSDFAVVLDCQADGLPAPTVSWKLRKEGGEIDLGVFDEEKVPEEAVVETNDVLDKRVMAFRNGTLVIPQLSESEEGAYTCVATNDMGESSASARITL 348
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Match: lingo4b (leucine rich repeat and Ig domain containing 4b [Source:ZFIN;Acc:ZDB-GENE-091214-3]) HSP 1 Score: 74.7146 bits (182), Expect = 3.826e-14 Identity = 99/379 (26.12%), Postives = 148/379 (39.05%), Query Frame = 1
Query: 268 LVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLK--------YLS---------LRNNALIISN---NTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLE-EMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLP----LSKFECKPKTLRLGKT--LVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYG--IDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAI 1311
L+ END++ + F + L L K N+ ++ D+L L L L I I +FK +LK YLS L +L +++ TF + +L+ L YL+LS NP+G+I DL L EL++ + I Q + + S L E FQ + L+ L L NP ACDCR+ W R LN + H +C TPDY+ ++L D P + F C+ +R + +V +V CQ E P + W ++ LS+S GR V +Y D G Y C TN G+ TL ++ H +
Sbjct: 169 LMMAENDVVYISQHAFSGLYSLEQLTLEKYNLTVVPRDSLMHLHRLKVLRLKYMNINSIPPYSFKRLVRLKILEIDHWPYLSRLPPKSLYGLNLTSLSVTHCNLTTFPHAAMHHLVYLRYLNLSHNPLGVIEAHALSDLVRLTELHVSNAQLLAIEPQAFSGLLHLRVLNTSGNLLTTLE-----ENVFQALGNLDVLRLDGNPLACDCRLLWILRRRRRLNFDG--------------HQPICATPDYVHGQELKDFPEILLPNHFTCQRARIREKEPEHYIVMEGHSVRFPCQAEGDPTPRIHWVSP-------QRKVLLSRSVGRLLVTADGSIEVRYAQTQDGGTYTCVATNAGGTDSYTVTLFVRKIEHDAGPL 521 HSP 2 Score: 55.0694 bits (131), Expect = 5.566e-8 Identity = 46/131 (35.11%), Postives = 63/131 (48.09%), Query Frame = 1
Query: 262 FSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL-IISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEE 651
+S+VC L+T P I D +LDLSKN ++ + + L L L N I I AF N L + L++N L +IS VF L L LD+S N I I+ + F +L NLR L + E
Sbjct: 50 WSVVCHRKRLLTIPDG--IPIDTRVLDLSKNRLKCINYGDFSGYPQLQELDLHENVISNIEPGAFNNLHHLHTIHLQSNRLKLIS-----MGVFAGLQNLTQLDISENKIVILLDYMFHNLHNLRWLMMAE 173
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010345.1 (pep scaffold:Pmarinus_7.0:GL477728:405586:411287:1 gene:ENSPMAG00000009370.1 transcript:ENSPMAT00000010345.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 68.5514 bits (166), Expect = 1.075e-12 Identity = 60/199 (30.15%), Postives = 91/199 (45.73%), Query Frame = 1
Query: 268 LVCIENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLIT 858
L+ +N +++F S F +++ LD+ NNI L A +L+ L L NKI +I+ AF L YL+L NN + T + L LE L L++N I + S F L NLRELY M + + SN+ +L + F + L+ + LH NP+ CDC++ +WL T
Sbjct: 136 LILGKNSILSFTSSTFQGLSELSDLDMPMNNITSLPALAFQHTPSLVILDLAYNKIQQISPKAFVGLKNLDYLNLDNNKI----TTIAPGTLQSLQNLEMLVLNNNNIKRVTSSTFKGLTNLRELYFSNNMVSVLTKDAFNSNIKLTQLTISDNKIKVIEAG----TFSTLSGLQMIYLHGNPYHCDCKLNPLVQWLAT 326
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Match: lrfn5a (leucine rich repeat and fibronectin type III domain containing 5a [Source:ZFIN;Acc:ZDB-GENE-080327-17]) HSP 1 Score: 67.781 bits (164), Expect = 6.228e-12 Identity = 88/348 (25.29%), Postives = 150/348 (43.10%), Query Frame = 1
Query: 253 RKQFSLVCIENDLITFPKSNFINKDIAI-LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQL---------ETLLLH--DNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTL-RLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSA 1257
R+ L +N + + + +F N + + L LS+N I + A D +L L D N++ I N +FK S L++L + NN L ++ + + +L+ LE LDL+ N + +P + +L L L+ M + I+ G FS+L L L + N LP + F +QL L+L+ NP C+C + W +R L + +D +E C +P L K +P +F C+P + R L+V + TL C+ P +V W + + R + N + + ++K DDG + C +N G +
Sbjct: 51 RRTVELRLGDNFITSVRRQDFGNMTLMVDLTLSRNTISQIAPYAFADLSSLTFLHFDYNRLTHIGNKSFKGLSNLRHLIISNNQL---SDISVGAFDDFLMSLEDLDLAYNNLEKVPWEAIQKMTSLHTLSLDHNMIDY-IEAGTFSHLHKLARLDMTSNKLQKLPP--DPLFTRLQLFANKGIHHTPPLVLNFGGNPLHCNCELLWLRR----LTREDD-----LET---------CASPQALVGKYFWSIPEEEFVCEPPLITRHTHRLLVLEGQRATLKCKAIGDPDPWVHWISPDEKVISNTTRTVVHD----NGTLEILVTTTK---DDGTFTCIASNPAGES 367
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Nematostella
Match: EDO49554 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGL8]) HSP 1 Score: 52.373 bits (124), Expect = 6.400e-7 Identity = 44/156 (28.21%), Postives = 79/156 (50.64%), Query Frame = 1
Query: 826 RMRWFKRWLITLNQNNDHLYSTI--ENILLNIHPMLC-ETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK 1284
R++ R+ I+ ++ ND +YS + E + P C + D + L +L +++ +P+ + K + VKH E T S + + PK V W+K+G ++++ + IQL +S G Y + + + D G Y+CE TN G A + + IK
Sbjct: 415 RIKDGGRFTISESEEND-MYSLVIDEARTEDSGPYKCVASNDAGKTTALLNLDVNEKVVQPEFDKEVKPIEVKHGEEATTSLEIKGKPKPKVTWYKDGKVLRESKN-IQL-KSIGDTYSIRIVRTAPE---DVGTYMCEATNKAGLASRKFDITIK 564
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Nematostella
Match: EDO35407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLJ8]) HSP 1 Score: 51.2174 bits (121), Expect = 6.605e-7 Identity = 34/103 (33.01%), Postives = 58/103 (56.31%), Query Frame = 1
Query: 343 LSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEE 651
+S++ +++L + D++ L L L +N I I + F+N LK L+L N + T +S+F+ L+ LE LDL N + +P F L++LREL+L +
Sbjct: 1 VSRSPLKLLKNTSFQDYQYLKWLDLSNNDISDIQDGTFENLRYLKQLNLGENKI----RTVSASMFKGLVSLEKLDLRFNDLKALPRGVFKPLKSLRELFLHD 99
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Nematostella
Match: EDO47109 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNB0]) HSP 1 Score: 49.2914 bits (116), Expect = 5.310e-6 Identity = 38/113 (33.63%), Postives = 56/113 (49.56%), Query Frame = 1
Query: 274 CIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFF 612
C L T P S + +++ L L+ N+IR L A ++ +L L L +N++ I N FK+ KLK L+L +N L + + FR L L YL L N I I + F
Sbjct: 58 CSNATLQTIPTS--LPRNLGSLFLNTNHIRALQAKAFANYLSLRVLDLSNNELSVIANGTFKSLGKLKTLTLNSNRLEV----VYAETFRGLRDLRYLSLRHNSIRTIGDGAF 164
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Nematostella
Match: EDO49555 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGL9]) HSP 1 Score: 44.2838 bits (103), Expect = 7.376e-6 Identity = 26/87 (29.89%), Postives = 45/87 (51.72%), Query Frame = 1
Query: 1024 LVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK 1284
+VV+ E++ + Q + PK VKW+K+G ++D + R+ + N + S+K D G Y CE TN VG A + + ++
Sbjct: 1 IVVRQGEDIDIGAQITAKPKPNVKWYKDGKPLRDG----PRTTIRARDDLYNCKVLSAKPE-DTGMYKCEATNAVGKATRTFDVQVE 82
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Match: lingo4b (leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 [Source:NCBI gene;Acc:101164675]) HSP 1 Score: 86.6557 bits (213), Expect = 3.668e-17 Identity = 98/371 (26.42%), Postives = 162/371 (43.67%), Query Frame = 1
Query: 280 ENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRN---------NALIISNNTFLS-----------SVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLP----LSKFECKPKTL--RLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYG--IDDGCYVCETTNNVGSARSNYTLIIK-IPSHK 1299
ENDL+ + F +++ L+L ++N+ + +AL ++L + + I + NNAF+ +L+ L + N N+LI N T L+ + R+L+ L +LDLS NPI +I + DL L+EL+L +RI+ GAF L ++L++ N +L E F + L+ L L NP ACDCR+ W R LN + H C +PD +Q+++ D + F C+P + R + V+ V SC+ + P + W I H + + +GR V ++ D G Y C N G+ + L +K +P +K
Sbjct: 162 ENDLVFISQRAFFGLQNLQELNLDRSNLTSIPTEALTQLQSLTVIRMFRLTISSLPNNAFRRLPRLRTLQILNWPALDTIASNSLIGLNLTSLTISSCNLTAVPYAALRHLVYLRFLDLSYNPITVIQGNLLGDLLRLQELHLAG-ASLLRIEPGAFKGLSFFRMLNVTSNMLTTLE---ESAFHSVGNLQVLRLDGNPLACDCRLLWVMRRRQRLNFDG--------------HQPTCSSPDAVQQREFRDFSEKELVRLFTCRPARIMDRRPQEARVEEGTTVLFSCKADGDPFPTITW------ISSHKNTV---SPTGRIRVLPNGTLEVRFAQVQDSGTYQCLAVNAAGNDSMSVGLYVKGVPRNK 505
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Match: lingo4b (leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 [Source:NCBI gene;Acc:101164675]) HSP 1 Score: 86.6557 bits (213), Expect = 3.668e-17 Identity = 98/371 (26.42%), Postives = 162/371 (43.67%), Query Frame = 1
Query: 280 ENDLITFPKSNFIN-KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRN---------NALIISNNTFLS-----------SVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLP----LSKFECKPKTL--RLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYG--IDDGCYVCETTNNVGSARSNYTLIIK-IPSHK 1299
ENDL+ + F +++ L+L ++N+ + +AL ++L + + I + NNAF+ +L+ L + N N+LI N T L+ + R+L+ L +LDLS NPI +I + DL L+EL+L +RI+ GAF L ++L++ N +L E F + L+ L L NP ACDCR+ W R LN + H C +PD +Q+++ D + F C+P + R + V+ V SC+ + P + W I H + + +GR V ++ D G Y C N G+ + L +K +P +K
Sbjct: 162 ENDLVFISQRAFFGLQNLQELNLDRSNLTSIPTEALTQLQSLTVIRMFRLTISSLPNNAFRRLPRLRTLQILNWPALDTIASNSLIGLNLTSLTISSCNLTAVPYAALRHLVYLRFLDLSYNPITVIQGNLLGDLLRLQELHLAG-ASLLRIEPGAFKGLSFFRMLNVTSNMLTTLE---ESAFHSVGNLQVLRLDGNPLACDCRLLWVMRRRQRLNFDG--------------HQPTCSSPDAVQQREFRDFSEKELVRLFTCRPARIMDRRPQEARVEEGTTVLFSCKADGDPFPTITW------ISSHKNTV---SPTGRIRVLPNGTLEVRFAQVQDSGTYQCLAVNAAGNDSMSVGLYVKGVPRNK 505
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Match: lrrc24 (leucine-rich repeat-containing protein 24 [Source:NCBI gene;Acc:101166166]) HSP 1 Score: 80.8777 bits (198), Expect = 2.143e-15 Identity = 65/251 (25.90%), Postives = 115/251 (45.82%), Query Frame = 1
Query: 358 IRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKT-LVVKHLENVTLSCQFESFPKSYVKWFKN 1107
++I +D L E+L L L +N I + AF N+ +L L+L N + + +F+ L L L L+ N I I + F L+ L+EL+L+E E+ + L + ++L+ + L+ L + +NPW CDC + W + W ++++ L S+ E L +C P L L ++ + C P ++L + L V+ E++ +SCQ +P+ V W K+
Sbjct: 64 VQIRLQD-LTGLESLHYLYLQNNSISALEPGAFLNQGQLLELALNGNLI----HLVTPDMFQGLEHLRILYLAGNQITRIQDHTFRGLQRLQELHLQENSIELLAEHALSGLSSLALLDLSKNHLRTLGASFLK---PLVSLQVLRVTENPWRCDCALAWLRTW---ISEDGQRLLSSAEQRRL-----MCSEPPRLSHLSLAEVAPNSLVCIPPVVQLEPSHLTVRLGESLRVSCQASGYPQPLVTWKKS 298
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Match: lrrc24 (leucine-rich repeat-containing protein 24 [Source:NCBI gene;Acc:101166166]) HSP 1 Score: 80.4925 bits (197), Expect = 2.838e-15 Identity = 65/251 (25.90%), Postives = 115/251 (45.82%), Query Frame = 1
Query: 358 IRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKT-LVVKHLENVTLSCQFESFPKSYVKWFKN 1107
++I +D L E+L L L +N I + AF N+ +L L+L N + + +F+ L L L L+ N I I + F L+ L+EL+L+E E+ + L + ++L+ + L+ L + +NPW CDC + W + W ++++ L S+ E L +C P L L ++ + C P ++L + L V+ E++ +SCQ +P+ V W K+
Sbjct: 64 VQIRLQD-LTGLESLHYLYLQNNSISALEPGAFLNQGQLLELALNGNLI----HLVTPDMFQGLEHLRILYLAGNQITRIQDHTFRGLQRLQELHLQENSIELLAEHALSGLSSLALLDLSKNHLRTLGASFLK---PLVSLQVLRVTENPWRCDCALAWLRTW---ISEDGQRLLSSAEQRRL-----MCSEPPRLSHLSLAEVAPNSLVCIPPVVQLEPSHLTVRLGESLRVSCQASGYPQPLVTWKKS 298
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Match: lrrc4bb (leucine-rich repeat-containing protein 4B [Source:NCBI gene;Acc:101159140]) HSP 1 Score: 80.4925 bits (197), Expect = 3.346e-15 Identity = 103/369 (27.91%), Postives = 156/369 (42.28%), Query Frame = 1
Query: 322 KDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNAL--------------------------IISNNTFLSSV-FRYL----------------IRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFEC-KPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWF-KNGILIQDHWDRIQLSQ-SSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIP 1290
+ + IL LSKN+IR + A + NL L L N++ + + AF+ SKL+ L LRNN + IS F V R+L ++LE L+LS N +GI+ F L +LR+L+L + I++ AF L +L+ L+L+ N+ SLP+ L QLE + L+ NPW C+C + W WL +N + C P L+ K + +L S F C P + L V L C+ + S V WF NG L+ R+++S G N+T+ D G Y C TN+ G+ ++ L + P
Sbjct: 92 RHLEILQLSKNHIRQIEVGAFNGLPNLNTLELFDNRLTVVPSQAFEYLSKLRELWLRNNPIETLGAFAFHRVPSLRRLDLGELRKLDFISEAAFEGLVNLRFLNLGMCGLKDIPNLTPLVKLEELELSGNQLGIVRPGSFQGLVSLRKLWLMHSRVSV-IERNAFDELKSLEELNLSHNSLHSLPHDLFTPLH--QLERVHLNHNPWVCNCDVLWLSWWLKETVPSNTTCCAR------------CHAPPGLKGKYIGELDQSHFPCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWFTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQ------DTGQYTCMVTNSAGNTTASAVLNVSAP 438
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Match: SMESG000006503.1 (SMESG000006503.1) HSP 1 Score: 1170.61 bits (3027), Expect = 0.000e+0 Identity = 623/625 (99.68%), Postives = 625/625 (100.00%), Query Frame = 1
Query: 187 MKFLFLMEFSLILKGYFLFDCVRKQFSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDYKKQQXXXXXXXVASXXXXXXXXXXXXXYCFYGNSLTNENKFKILKKSDLLYVNDKVLMTCNSDIISTSPLLQIISKTDEHNGFLKWNNHVPIDAKDSDEKKLIIDSFENQVESNENPIVKNFMVNESIFSNHTSDSDNHSCQLSIHEDCPIHGTGNSYSCPIHDSENETIVLENQSYNWSYVFNNKNTITNNYYSLKSAFNNKNGRSNINPMTDSYSMNIKKSEIDKIDCGIPIEKVSSQLSFNIDQI 2061
MKFLFLMEFSLILKGYFLFDC+RKQFSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGAFSNLFNLKLLSLAKNNFLSLPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNND+LYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDYKKQQIILLLIIVASGIITLIILVGIVIYCFYGNSLTNENKFKILKKSDLLYVNDKVLMTCNSDIISTSPLLQIISKTDEHNGFLKWNNHVPIDAKDSDEKKLIIDSFENQVESNENPIVKNFMVNESIFSNHTSDSDNHSCQLSIHEDCPIHGTGNSYSCPIHDSENETIVLENQSYNWSYVFNNKNTITNNYYSLKSAFNNKNGRSNINPMTDSYSMNIKKSEIDKIDCGIPIEKVSSQLSFNIDQI
Sbjct: 1 MKFLFLMEFSLILKGYFLFDCIRKQFSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGAFSNLFNLKLLSLAKNNFLSLPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDYLYSTIENILLNIHPMLCETPDYLQRKKLCDLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDYKKQQIILLLIIVASGIITLIILVGIVIYCFYGNSLTNENKFKILKKSDLLYVNDKVLMTCNSDIISTSPLLQIISKTDEHNGFLKWNNHVPIDAKDSDEKKLIIDSFENQVESNENPIVKNFMVNESIFSNHTSDSDNHSCQLSIHEDCPIHGTGNSYSCPIHDSENETIVLENQSYNWSYVFNNKNTITNNYYSLKSAFNNKNGRSNINPMTDSYSMNIKKSEIDKIDCGIPIEKVSSQLSFNIDQI 625
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Match: SMESG000006317.1 (SMESG000006317.1) HSP 1 Score: 147.902 bits (372), Expect = 6.749e-37 Identity = 122/384 (31.77%), Postives = 201/384 (52.34%), Query Frame = 1
Query: 328 IAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYS---TIEN--ILLNIHPMLCETPDYLQRKKLC-------DLPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDYKKQQXXXXXXXVASXXXXXXXXXXXXXYCFYGNSLTNENKFK 1443
+A + + N+ ++ L + NL+NLTL+SNKI K++ NAF + +L L L N + + N+ SS YL +L LDLS NP+G +P+ +F L+ LR L L K I+ L NL++L L N+F +L L + MQL L +NPW CDC ++W K W + S TI I+ ++ P CE+P L + + + ++ +C P+ + + N+T +C+F + P V W KNG+++Q+HW R+ ++S G + A LT+ + + D G + C T +V ++ N T ++K+ S + N ID+K I+ + I A +I L++++GI+IYC YG + N + K
Sbjct: 65 VAEIIIENQNLSVIDSAQLKNLPNLVNLTLNSNKITKLSPNAFTHVPQLISLRLSGNQIYLGENSMPSSSLIYLKKLHTLDLSENPLGFVPDYYFQLLKQLRILNLSTANKGFYIETNGLYGLTNLQVLDLTNNHFTTLSEGLSISLKAMQLNEFYLFNNPWNCDCNLQWLKAWFTSHKVKYTKDLSKDITINGGKIIEDLQPK-CESPFPLSERNIFSDSTNTDSIGINDLKCAPRIFTQDRVYEMTKDHNITFTCEFHANPGGTVTWSKNGMIVQNHWRRVSWNRSQGIKFKAWLTLQNVEEN-DSGNWRCILTTHV--SKVNATFLLKVISPQ-NIIDFKS--ILKYVGIGAVTLILLLVVIGIIIYCVYGFQIQNNRRPK 441
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Match: SMESG000058478.1 (SMESG000058478.1) HSP 1 Score: 145.591 bits (366), Expect = 7.047e-36 Identity = 108/372 (29.03%), Postives = 175/372 (47.04%), Query Frame = 1
Query: 247 CVRKQFSLVCIENDLITFPKSNFINKDIAILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLY-----STIENILLNIHPMLCETPDYLQRKKLCD-------LPLSKFECKPKTLRLGKTLVVKHLENVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIK--IPSHKDNAIDYK 1320
C R + I +DL F + L++ NI L D L L +L LDSNK+ I +AF N KLK LSL++N LI+ N+F S+ L L+ LDL +NP+G +P+ FF L+ L +L L ++ + L +L+ L ++ ++ +L + MQL N W CDC ++W K+W L + ++ S ++ LL C +P Q + + + + C PK + + + +N+TL C+FE+ P V+W KNG+ +Q HW + + Q+SG + A L+I + D+G + C + SA + Y+L ++ P H D I K
Sbjct: 44 CSRLETKFTRIPHDLPDF---------VETLEVKNQNIHSLTADQLVKVGWLEDLNLDSNKLSSIEFDAFNNVPKLKTLSLKSNFLILGGNSFPSAALLQLKHLKVLDLDNNPLGFVPDFFFQPLKFLTKLILSRATNGFYLEPNSLVGLTSLEYLDISASHLTALDRQIHSALNNMQLTDFYFFGNQWTCDCNLKWLKKW--GLKHKDVRIFKKFSRSNGQSALLQPQ---CFSPHKFQGYNIFEFSTEYDTIKPEQLNCPPKIFTKNQQIQIDQGKNLTLMCEFEADPGGTVEWSKNGMRVQRHWKKTKWGQTSGMRFTAWLSITRTDLE-DNGLWRCILITDTQSANATYSLRVRPSFPPHIDLTIILK 400
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Match: SMESG000023338.1 (SMESG000023338.1) HSP 1 Score: 112.464 bits (280), Expect = 3.161e-25 Identity = 102/325 (31.38%), Postives = 169/325 (52.00%), Query Frame = 1
Query: 334 ILDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISNNTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDLRNLRELYLEEM-MKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEMQ-LETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKL---CDLPLSK---FECKPKTLRLGKTLVVKHLE-NVTLSCQFESFPKSYVKWFKNGILIQDHWDRIQLSQSSGRNYVANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLII 1281
+L +++ NI ++ E+ + L L+L + + +I NAFKN S L L L N LI+++++ S + L+ L++L L++NP+ +IP+ FF L +LR+L L + +RI AF L +L+ L L + ++ +E +F+EM+ L LLL +NPW CDC +RW R+L + + + T++ L N C+ P L+ ++ D SK F C K R+ VV E ++ L+C+ S P V W KNG +++ ++ Q+ S N+ + L I S K +D G + C V N+TL I
Sbjct: 63 MLIITQQNIPVIKEEDFKNVLELSTLSLTFSNLERIHRNAFKNLSYLTILDLSGNKLILNDDSLPSYLITNLVNLKHLKLTNNPLKMIPDFFFKPLSSLRKLLLNDCGFDSLRISSRAFHGLNSLEELDLRNSGIETINKTMESDFREMKPLRVLLLGENPWICDCHLRWLYRYLGEIQE-----FITLQ--LDNKVGPRCKQPKRLENYRIIAGIDRNQSKYVEFVCPIKCSRVSPGNVVLDSEKSLNLTCKCFSDPIKPVIWTKNGYKVEETVNKFQIFNSGNENFYSTLHIRSLK-SVDSGSWSCR----VDDVFQNFTLKI 375
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Match: SMESG000075643.1 (SMESG000075643.1) HSP 1 Score: 105.916 bits (263), Expect = 1.739e-23 Identity = 109/366 (29.78%), Postives = 178/366 (48.63%), Query Frame = 1
Query: 271 VCIENDLITFPKSNF--INKDIAI----LDLSKNNIRILYEDALDDFENLINLTLDSNKIWKITNNAFKNKSKLKYLSLRNNALIISN-NTFLSSVFRYLIRLEYLDLSSNPIGIIPESFFLDL-RNLRELYLEEMMKEIRIQKGXXXXXXXXXXXXXXXXXXXXXPNYLEYEFQEM-QLETLLLHDNPWACDCRMRWFKRWLITLNQNNDHLYSTIENILLNIHPMLCETPDYLQRKKL---CDLPLS--KFECKPKTLRLGKTLVVKHLENVTLSCQFESFPK-SYVKWFKNGILIQDHWDRIQLSQSSGRNY-VANLTIFSSKYGIDDGCYVCETTNNVGSARSNYTLIIKIPSHKDNAIDYK 1320
V I ND P +N I KD+++ L++ N+ L + L LTL+S + I+ AF++ S+L L+L NN+L+I + N S +F+ LI L LDLS N I +IP+ FF L ++L+ L + I + S+L L+ L ++ NN + L + E F +M L+ L+LH NPW CDC++RW W + S+ + L + LC +P + L +P+ +F C PK L V ENV+L C F+S + + +KW NG L++ + + + R+ V L F+ K CY+ N +G +N++++ + S+ D +K
Sbjct: 43 VAICND----PSTNLERIPKDLSVNLIRLEMMYQNLTSLEANEFSHIYQLELLTLNSCGVRHISTTAFEHLSQLVILTLSNNSLVIHDINNLQSEIFQPLIGLTLLDLSFNFIQMIPKHFFRYLEKSLKVLIISNSKSPFSISPDSLSDLVRLERLDISHNNLIQLDSGFESVFSKMISLQNLILHGNPWKCDCKIRWLVFWYQHSTLGSFPAESSPSS-LSHFQSALCHSPRSMHNAILLRSISIPIKSHEFPCFPKCLSKNSDFFVGEGENVSLPCSFQSLDQYTRIKWSHNGTLLKSNSRNYVIKSDTKRHRSVLTLIHFTIKLSGLWRCYILFDDNIIG---TNFSVLFRWSSNNDKQYHFK 400 The following BLAST results are available for this feature:
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 4
BLAST of Leucine Rich repeat-containing domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Leucine Rich repeat-containing domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021280 ID=SMED30021280|Name=Leucine Rich repeat-containing domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2323bpback to top protein sequence of SMED30021280-orf-1 >SMED30021280-orf-1 ID=SMED30021280-orf-1|Name=SMED30021280-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=626bp MKFLFLMEFSLILKGYFLFDCVRKQFSLVCIENDLITFPKSNFINKDIAIback to top Aliases
The feature 'Leucine Rich repeat-containing domain protein' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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