Hydroxysteroid 17-beta dehydrogenase 4

Query:  126 TKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            + L F+  V +VTG+G GLGR YAL  A+RGA VV+NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:    3 SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 605          

Query:  126 TKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            + L F+  V +VTG+G GLGR YAL  A+RGA VV+NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:    3 SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 605          

Query:  126 TKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            + L F+  V +VTG+G                   +NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:    3 SPLRFDGRVVLVTGAG------------------AVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 587          

Query:  225 VVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            V +NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:   12 VSMNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 581          

Query:  225 VVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            V +NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:   61 VSMNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 630          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ 1022
            L F+  VA+VTG+GGGLG+TYALELAKRG KVV+NDLG  R G  +  S A+KVV E+K+ GG A  NYDSV  G+ I+  AI  FG+IDI+INNAGILRD SF+ ++  DW+ +  VH+ GAY  TK+AW +MR+Q +GRI+ TSS++G++GNFGQ+NY+AAK  L+GL N+L+ EGAKYNI  NT+ P AGSRLTE V P  L +ALKP+YV+PLV Y+ H S EESG +FE GAGW G +++  S+G   K   H   + +D+  +W  IT+ + + +  +  E     V +L+
Sbjct:    3 LRFDGKVAIVTGAGGGLGKTYALELAKRGCKVVVNDLGGDRHGTSSSSSMADKVVQEIKSAGGQAVANYDSVEFGDKIVKTAIDNFGRIDIVINNAGILRDVSFLKMTELDWDLIFKVHVKGAYAVTKAAWPYMRDQKYGRIVVTSSNAGVHGNFGQANYAAAKSALIGLSNSLAQEGAKYNILANTLVPTAGSRLTETVMPQNLVDALKPDYVTPLVTYMVHDSFEESGKVFEAGAGWYGTIQYYKSKG---KVISH--ASADDIAKNWSTITNMNGAEYIGTITEQSARLVSILE 294          

Query: 1125 QNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDH-DVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRL-NGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIKPKL 1949
            +++I+YA+ VG      E+L ++YENH +F VLP+Y V   F       + L D   V  DL ++LHGEQY+E+++P+  + K  + A +VD+LDK  GA++L N T ++   + I+  QFS +  G+G F G + S  E  +  +PDR PDA+IEQ    +QA LYRL +GD+NPLHVDPEF+K+ GFK PILHGLCS G  ++  I  +A  +SDKFK IKVRFS PV+PGQTL+TE WK+ K +  Q K+KETG I +S  +I+ ++A+  P +
Sbjct:   21 RDAIIYALGVGARAK--EDLCYVYENHEDFKVLPSYIVAPGFQA-----HTLMDWPGVEFDLQRVLHGEQYIEVYQPLSAEGKLKSEARVVDILDKGSGALILGNVTTYDENGKKIAMQQFSTFQTGSGNFGGDRTSPHEIKAATVPDRAPDAVIEQKTTVDQAALYRLGSGDMNPLHVDPEFAKMSGFKTPILHGLCSLGFATRHVIAAWAGNDSDKFKAIKVRFSSPVLPGQTLVTETWKNGKRIIFQMKVKETGKIVISNAFIDLHEASELPTV 290          

Query:  135 LFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKS-AWTHMRNQNFG-RIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP-VAGSRLTEDVFPPELFEALK---------PEYVSPLVLYLCHP-SSEESGSLFEVGAGW 848
            L    +AVVTG   G+G+  +  LAK GA+VV+ DL    D      +      ++  +       N DSV      ++  +K  G   IL+N AGI +D + + +  + W+ VI V+L G +  +++     + N N    II  SS  G  GNFGQ+NY+A K G++G   + + E AK N++ N + P    + +TE + P  L E  K          E ++  VLYL    SS  +G+  EV  G+
Sbjct:    4 LLGGRIAVVTGGASGIGKAISQTLAKHGARVVVADL----DSGNAAATAKALPASQSHSSFACDVSNADSVKG----LSEHVKSLGTPSILVNCAGITKDSTLLKMKQEQWDSVIKVNLTGVFHVSQAFVKASVDNNNHPLSIINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVLPGFIKTPMTEAMPPTVLAEICKGIPMGRMGEAEEIANSVLYLASDLSSYVTGATLEVTGGF 246          

Query:  156 VVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLS--LEGAKYNIKCNTIAPVAGSRLTEDVFP---PELFEALKPEYVSPLVL 788
            ++TGSG GLGR  A E  K GA++V+ D+     G+   L     +  E KA+  +    Y  +    +++     E GK+DIL+NNAGI+  K  +   ++   + ++V+ +  + TTK+    M   N G I+  +S +G  G  G  +Y A+K G VG  ++L+  L   K ++K   + P+  +    D      P L   L PEYV   ++
Sbjct:   43 LITGSGSGLGRLMAFEFGKLGARLVLWDIN--EQGNKETLKELEAMGVEAKAYT-VDLSEYKEINRTADLVK---SEVGKVDILVNNAGIVTGKKLLQCPDELMVKTVSVNTNALFFTTKNFLPGMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCPIYINTGMFDGIATKWPTLLPILSPEYVVDCIM 252          

Query:  156 VVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLS--LEGAKYNIKCNTIAPVAGSRLTEDVFP---PELFEALKPEYVSPLVL 788
            ++TGSG GLGR  A E  K GA++V+ D+     G+   L     +  E KA+  +    Y  +    +++     E GK+DIL+NNAGI+  K  +   ++   + ++V+ +  + TTK+    M   N G I+  +S +G  G  G  +Y A+K G VG  ++L+  L   K ++K   + P+  +    D      P L   L PEYV   ++
Sbjct:   43 LITGSGSGLGRLMAFEFGKLGARLVLWDIN--EQGNKETLKELEAMGVEAKAYT-VDLSEYKEINRTADLVK---SEVGKVDILVNNAGIVTGKKLLQCPDELMVKTVSVNTNALFFTTKNFLPGMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCPIYINTGMFDGIATKWPTLLPILSPEYVVDCIM 252          

Query:  129 KLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNS--ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIA--CFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKS-DKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIK 1940
            KL ++  VAVVTG+G GLGR YAL  A+RGAKVV+NDLG    GDG     A+ VV+E++  GG A  +Y+SV+DG  +I  AIK FG++DIL+NNAGILRD+S V  S  DWN V +VHL G++K T++A+ +M+ QN+GRII TSS+SGIYGNFGQ NY+AAK+GL+GL NT+++EGA+ N+ CN I P A SR+TE + P  LF  LKP+ ++P+V YLCH S E++GS  E  AGW  K+     +G +L+    + VT+E V+D W  +TD S+++H  +  E+    +++L+   +   +  E                  D   F +   I YA+ +G +    ++++FLYEN ++F+ +PT+ V+         D L   +  +  +D S ILHGEQYLE+   +       T  ++ DV+DK  GAVV+ N+   +    L+ + Q + +I GAG F GKK       P +  P+R+PDA ++     +QA LYRL+GD NPLH+DP+ + L GFK PILHGLC+ G   +  +  FAD N   FK +KVRFS PVIPGQTL  + WK    +  +  + ETG   +SG Y++   +  K
Sbjct:    7 KLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKEGGGDAIE------------------DAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDLKSSQAK 597          

Query:  129 KLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNS--ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIA--CFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKS-DKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIK 1940
            KL ++  VAVVTG+G GLGR YAL  A+RGAKVV+NDLG    GDG     A+ VV+E++  GG A  +Y+SV+DG  +I  AIK FG++DIL+NNAGILRD+S V  S  DWN V +VHL G++K T++A+ +M+ QN+GRII TSS+SGIYGNFGQ NY+AAK+GL+GL NT+++EGA+ N+ CN I P A SR+TE + P  LF  LKP+ ++P+V YLCH S E++GS  E  AGW  K+     +G +L+    + VT+E V+D W  +TD S+++H  +  E+    +++L+   +   +  E                  D   F +   I YA+ +G +    ++++FLYEN ++F+ +PT+ V+         D L   +  +  +D S ILHGEQYLE+   +       T  ++ DV+DK  GAVV+ N+   +    L+ + Q + +I GAG F GKK       P +  P+R+PDA ++     +QA LYRL+GD NPLH+DP+ + L GFK PILHGLC+ G   +  +  FAD N   FK +KVRFS PVIPGQTL  + WK    +  +  + ETG   +SG Y++   +  K
Sbjct:    7 KLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKEGGGDAIE------------------DAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDLKSSQAK 597          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYP-NYDSVVDGENIIACAIKEFGKID-ILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNF--GRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP----------VAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHP-SSEESGSLFEVGAGW 848
            VA+VTG+G G+GR     LA+ GAKV+  D          +L  A + V E+ +    A   +  S    +  +A A+K+F +   I++N+AGI RD   + +   D++ V  V+L G +  T++    M  Q    G I+  SS      N GQ+NY+A K G++      S E  K+ I+ N I P          V  S   E V    L    +PE ++ ++ +L  P SS  +G+  EV  G 
Sbjct:   10 VALVTGAGSGIGRATCRLLARDGAKVIAVD---------RNLKAAQETVQELGSERSAALEVDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLVTQAYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTEVASKEFGKFGIRVNCILPGYIDTPMVAVVPDSVKQEVVQRCPLGRLGQPEEIAEVIAFLASPQSSYVNGAAIEVTGGL 248          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYP-NYDSVVDGENIIACAIKEFGKID-ILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNF--GRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP----------VAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHP-SSEESGSLFEVGAGW 848
            VA+VTG+G G+GR     LA+ GAKV+  D          +L  A + V E+ +    A   +  S    +  +A A+K+F +   I++N+AGI RD   + +   D++ V  V+L G +  T++    M  Q    G I+  SS      N GQ+NY+A K G++      S E  K+ I+ N I P          V  S   E V    L    +PE ++ ++ +L  P SS  +G+  EV  G 
Sbjct:   10 VALVTGAGSGIGRATCRLLARDGAKVIAVD---------RNLKAAQETVQELGSERSAALEVDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYDDVYGVNLKGTFLVTQAYAKAMIEQKLENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTEVASKEFGKFGIRVNCILPGYIDTPMVAVVPDSVKQEVVQRCPLGRLGQPEEIAEVIAFLASPQSSYVNGAAIEVTGGL 248          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAI-KEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE 662
            VA+VTG G GLGR   LELA+RG K+ + D+      +        ++++++      AY N  S      ++A  + KE G +DIL+NNA ++   S   + +D+ + ++ ++L     TTK     M N+  G ++  ++ +G+    G   Y+A K G+ G   +L  E
Sbjct:   94 VALVTGGGSGLGREICLELARRGCKLAVVDV------NSKGCYETVELLSKIPRCVAKAYKNDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMTSTPSLKSDEIDTILQLNLGSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAE 259          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDEN---TNKTENVPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDA 1931
            L F+  V +VTG+GGGLGR YAL   +RGA V++NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+ID+++NNAGILRD+SF   S+ DW+ +  VHL G++  T++AW HM+ Q FGRII TSS++GIYGNFGQ+NYSAAKLGL+GL NTL++EG KYNI CNTIAP AGSRLTE V PP+L ++LK EYV+PLVL+LCH S +E+  LFEVGAGW+GK+RWE S G +++ K    VT E VRD W +I DF+ +  P+S +ES+Q  V++L    DE     N T  V  +  + IG          T  N ILYA+ VG+++   + L+FLYE H++FS LPT+ VI        LL   S   + ID +++LHGEQYLE++KP+      ++ A + DVLDK  G ++L++   + +++EL+   QFS++I G+GGF GK+ S K     A PDR  DA++ +    +QA LYRL+GD NPLH+DP F+ + GF+ PILHGLCSFG  ++  +  FA  +  +FK +KVRF KPV PGQ+L TE WK++  V++QC +KE+G + LSG YI+ + A
Sbjct:    5 LRFDGKVVLVTGAGGGLGREYALAFGQRGAAVIVNDLGGDIKGGGKSSAAADKVVEEIRAAGGKAVANYDSVEDGEKLIQTALDAFGRIDVVVNNAGILRDRSFARTSDVDWDLIQRVHLRGSFLVTRAAWNHMKQQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLLGLANTLAIEGQKYNIHCNTIAPTAGSRLTETVMPPDLVQSLKAEYVAPLVLWLCHESCQENSGLFEVGAGWIGKLRWERSLGRIVRQKSE-CVTPEAVRDAWRDICDFTNATKPASIQESLQTLVEVLSRVEDERKIGANPTA-VATNPAQAIGHVLPDMTFTHTHMNCILYALGVGVSSRDPQQLQFLYEGHTHFSCLPTFGVIPAQGA---LLGLGSIPGLDIDFTRLLHGEQYLELYKPLPTSGTLTSRATVADVLDKGSGMLILLDVHTY-SEQELLCYNQFSVFIVGSGGFGGKRVSQKAVAPAAPPDRPADAVVVEETSRDQAALYRLSGDWNPLHIDPNFAAMGGFQSPILHGLCSFGFAARHVLKQFAGNDVSRFKAMKVRFVKPVYPGQSLQTEMWKENSRVHIQCTVKESGAVVLSGAYIDLHPA 601          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLG-------------VLRDGDGNDLSPANKV--VNEVKAFGGIAYPNYDSVVDGENIIACA---IKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V V+TG+GGGLGR +A E A+R A +V+ D+              + R+ D N +S    V  V EV  F    Y     V   E++ + A    KE G++D+LINNAG++     +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G +G   +LS E     K  IK   + P         G R+ +++ P      L+PE+
Sbjct:   38 VCVITGAGGGLGRLFAKEFARRRATLVLWDINSHSNEETAEMVRQIYREQD-NPMSKEGAVGGVEEVPPFQPQVYTYVLDVGKRESVYSTAEKVRKEVGEVDLLINNAGVVSGHHLLECPDELIERTMVVNCHAHFWTTKAFLPKMLEMNHGHIVTVASSLGLFSTAGVEDYCASKFGAIGFHESLSHEIQASEKDGIKMTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLRPEF 269          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLG-------------VLRDGDGNDLSPANKV--VNEVKAFGGIAYPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V V+TG+GGGLGR +A E A+R A +V+ D+              + R+ D N +S    V  V EV  F    Y     V   E++ + A K   E G++D+LINNAG++     +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G +G   +LS E     K  IK   + P         G R+ +++ P      L+PE+
Sbjct:   38 VCVITGAGGGLGRLFAKEFARRRATLVLWDINSHSNEETAEMVRQIYREQD-NPMSKEGAVGGVEEVPPFQPQVYTYVLDVGKRESVYSTAEKVRREVGEVDLLINNAGVVSGHHLLECPDELIERTMVVNCHAHFWTTKAFLPKMLEMNHGHIVTVASSLGLFSTAGVEDYCASKFGAIGFHESLSHEIQASEKDGIKMTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLRPEF 269          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIA-------------YPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V V+TG+G GLGR +ALE A+R A +V+ D+   R  +      A ++  ++K   G +             Y     V   E++   A K   E G ID+LINNAG++  +  +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G +G   +LS E     K  IK   + P         G ++ +++ P   F  LKPEY
Sbjct:   38 VCVITGAGSGLGRLFALEFARRRATLVLWDIN--RQSNEETAEMAREIYRQLKPSTGSSDSVQELPLLQPKVYTYMCDVSKRESVYLTAEKVRSEVGDIDLLINNAGVVSGRHLLDCPDELIERTMMVNCHAHFWTTKAFLPKMLELNHGHIVTVASSLGLFTTAGVEDYCASKFGAIGFHESLSHELKAADKDGIKMTLVCPFLVDTGMFEGCKIRKEMAP--FFPPLKPEY 266          

Query:  126 TKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACA---IKEFGK-IDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLS-------LEGAKYNIKCNTIAPVA---GSRLTEDV---FPPELFEALKPEY 770
            TK +  +LV ++TGSGG LGR +ALE  K GA+VV+ D+    +G+ N+          V+A GG A+     V   E +   A    +E G+ +  L+NNAG++  +  +   +    R + V+ H  + T K+    M+++N G II  +S  G++      +Y A+K   VG   +L+       L+G K  + C  I       G R+ E+V    PP     L+P Y
Sbjct:   31 TKPIDGELV-LITGSGGALGRLFALEFTKHGAEVVLWDV----NGEANE-----DTAKLVRARGGQAHAYTVDVTKREEVYRTADLVREEVGRDVTYLVNNAGVVAGERLLDCPDYLLERTLKVNCHALFWTVKAFLPQMKDKNHGHIITIASVLGLFSTACVEDYCASKFAAVGFHESLAHELLTEDLDGVKTTLVCPYIVDTGMFEGCRIREEVALILPP-----LEPLY 247          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQN--SILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINA-TIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGRTYAL  A+RGA V++NDLG    G+G   S A+KVV E++A GG A  NYDSV  GE ++  A+  FG+IDI++NNAGILRD+SF  IS+ DW+ +  VHL GA+  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGLVGL NTL++EG KYNI  N IAP AGSRLT+ V P +L +ALKPEYV+PLVL+LCH S +E+GSLFEVGAGWVGK+RWE S G +++ K   + T E VRD W +I+DF  +  P + ++S+     +L QT+      ++  +  T     S++ +    +   L   T+ +   ILYA+ VG++    ++LKFLYE   +FS LP++ VI      F      S   + ID +++LHGEQYLE++KP+    + ++ A + D++DK  GA++L++  T H    +L+   QFS+++ GAGGF GK+ S K   +   P R PD ++    + +QA LYRL+GD NPLH+DP F+ + GF+KPILHGLCSFG  ++  +  FA+ +  KFK IKVRF+KPV+PGQTL TE WK+   +++Q K+K+TG I ++G Y++  
Sbjct:    6 LRFDGRVVLVTGAGGGLGRTYALAFAERGASVIVNDLGGDIKGEGKSSSAADKVVEEIRAKGGKAVANYDSVEAGEKLVQTALDAFGRIDIVVNNAGILRDRSFARISDADWDIIHRVHLKGAFLITRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSRLTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQKNRPM-TPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVKAIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVIVS-QAAFMSGGLASVPGLNIDFTRVLHGEQYLEIYKPLPTSGEMTSHATVADIMDKGSGAIILLDVHTYHGV--DLVCYNQFSVFVVGAGGFGGKRSSSKAKATANPPSRPPDVVVTDATNADQAALYRLSGDWNPLHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMWKEGNRIFLQTKVKDTGEIAIAGAYVDLT 609          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQN--SILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINA-TIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGRTYAL  A+RGA V++NDLG    G+G   S A+KVV E++A GG A  NYDSV  GE ++  A+  FG+IDI++NNAGILRD+SF  IS+ DW+ +  VHL GA+  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGLVGL NTL++EG KYNI  N IAP AGSRLT+ V P +L +ALKPEYV+PLVL+LCH S +E+GSLFEVGAGWVGK+RWE S G +++ K   + T E VRD W +I+DF  +  P + ++S+     +L QT+      ++  +  T     S++ +    +   L   T+ +   ILYA+ VG++    ++LKFLYE   +FS LP++ VI      F      S   + ID +++LHGEQYLE++KP+    + ++ A + D++DK  GA++L++  T H    +L+   QFS+++ GAGGF GK+ S K   +   P R PD ++    + +QA LYRL+GD NPLH+DP F+ + GF+KPILHGLCSFG  ++  +  FA+ +  KFK IKVRF+KPV+PGQTL TE WK+   +++Q K+K+TG I ++G Y++  
Sbjct:    6 LRFDGRVVLVTGAGGGLGRTYALAFAERGASVIVNDLGGDIKGEGKSSSAADKVVEEIRAKGGKAVANYDSVEAGEKLVQTALDAFGRIDIVVNNAGILRDRSFARISDADWDIIHRVHLKGAFLITRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSRLTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQKNRPM-TPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVKAIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVIVS-QAAFMSGGLASVPGLNIDFTRVLHGEQYLEIYKPLPTSGEMTSHATVADIMDKGSGAIILLDVHTYHGV--DLVCYNQFSVFVVGAGGFGGKRSSSKAKATANPPSRPPDVVVTDATNADQAALYRLSGDWNPLHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMWKEGNRIFLQTKVKDTGEIAIAGAYVDLT 609          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKID-ILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQN--SILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGRTYAL  A+RGA V++NDLG    G+G   S A+KVV E++A GG A  NYDSV  GE ++  A+  FG+I  + I    ILRD+SF  IS+ DW+ +  VHL GA+  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGLVGL NTL++EG KYNI  N IAP AGSRLT+ V P +L +ALKPEYV+PLVL+LCH S +E+GSLFEVGAGWVGK+RWE S G +++ K   + T E VRD W +I+DF  +  P + ++S+     +L QT+      ++  +  T     S++ +    +   L   T+ +   ILYA+ VG++    ++LKFLYE   +FS LP++ VI      F      S   + ID +++LHGEQYLE++       KY T              V  I  T H    +L+   QFS+++ GAGGF GK+ S K   +   P R PD ++    + +QA LYRL+GD NPLH+DP F+ + GF+KPILHGLCSFG  ++  +  FA+ +  KFK IKVRF+KPV+PGQTL TE WK+   +++Q K+K+TG I ++G Y++  
Sbjct:    6 LRFDGRVVLVTGAGGGLGRTYALAFAERGASVIVNDLGGDIKGEGKSSSAADKVVEEIRAKGGKAVANYDSVEAGEKLVQTALDAFGRIVFVYIFPNRILRDRSFARISDADWDIIHRVHLKGAFLITRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSRLTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQKNRPM-TPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVKAIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVIVS-QAAFMSGGLASVPGLNIDFTRVLHGEQYLEIY-------KYETL-------------VPCIVHTYHGV--DLVCYNQFSVFVVGAGGFGGKRSSSKAKATANPPSRPPDVVVTDATNADQAALYRLSGDWNPLHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMWKEGNRIFLQTKVKDTGEIAIAGAYVDLT 589          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQN--SILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQ--ILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGRTYAL  A+RGA V++NDLG    G+G   S A+KVV E++A GG A  NYDSV  GE ++  A+  FG+I  L +N+       F  +++     +  VHL GA+  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGLVGL NTL++EG KYNI  N IAP AGSRLT+ V P +L +ALKPEYV+PLVL+LCH S +E+GSLFEVGAGWVGK+RWE S G +++ K   + T E VRD W +I+DF  +  P + ++S+     +L QT+      ++  +  T     S++ +    +   L   T+ +   ILYA+ VG++    ++LKFLYE   +FS LP++ VI      F      S   + ID ++  I      + +H P  +   +                      T H    +L+   QFS+++ GAGGF GK+ S K                       +A LYRL+GD NPLH+DP F+ + GF+KPILHGLCSFG  ++  +  FA+ +  KFK IKVRF+KPV+PGQTL TE WK+   +++Q K+K+TG I ++G Y++  
Sbjct:    6 LRFDGRVVLVTGAGGGLGRTYALAFAERGASVIVNDLGGDIKGEGKSSSAADKVVEEIRAKGGKAVANYDSVEAGEKLVQTALDAFGRIGNLFSNSLY----CFFTLAD----IIHRVHLKGAFLITRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSRLTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQKNRPM-TPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVKAIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVIVS-QAAFMSGGLASVPGLNIDFTRVSIFPSTLSITLHFPFCLIYSFFAV------------------HTYHGV--DLVCYNQFSVFVVGAGGFGGKRSSSKA----------------------KAALYRLSGDWNPLHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMWKEGNRIFLQTKVKDTGEIAIAGAYVDLT 562          

Query:  258 GDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQN--SILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINA-TIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            G+G   S A+KVV E++A GG A  NYDSV  GE ++  A+  FG+I  L +N+       F  +++     +  VHL GA+  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGLVGL NTL++EG KYNI  N IAP AGSRLT+ V P +L +ALKPEYV+PLVL+LCH S +E+GSLFEVGAGWVGK+RWE S G +++ K   + T E VRD W +I+DF  +  P + ++S+     +L QT+      ++  +  T     S++ +    +   L   T+ +   ILYA+ VG++    ++LKFLYE   +FS LP++ VI      F      S   + ID +++                 K ++ A + D++DK  GA++L++  T H    +L+   QFS+++ GAGGF GK+ S K   +   P R PD ++    + +QA LYRL+GD NPLH+DP F+ + GF+KPILHGLCSFG  ++  +  FA+ +  KFK IKVRF+KPV+PGQTL TE WK+   +++Q K+K+TG I ++G Y++  
Sbjct:    3 GEGKSSSAADKVVEEIRAKGGKAVANYDSVEAGEKLVQTALDAFGRIGNLFSNSLYC----FFTLAD----IIHRVHLKGAFLITRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLVGLSNTLAIEGTKYNIHSNCIAPTAGSRLTQTVMPQDLLDALKPEYVTPLVLWLCHESCQETGSLFEVGAGWVGKLRWERSLGAIIRQKNRPM-TPEAVRDEWAKISDFDNADKPQTIQDSINPLYQVLSQTDSEKGMSMNPTSQGTSLSTSSIDPVKAIGQKLPLTTYTYSHLEPILYALGVGMSTRDPDHLKFLYEGSEDFSCLPSFGVIVS-QAAFMSGGLASVPGLNIDFTRV-----------------KMTSHATVADIMDKGSGAIILLDVHTYHGV--DLVCYNQFSVFVVGAGGFGGKRSSSKAKATANPPSRPPDVVVTDATNADQAALYRLSGDWNPLHIDPSFAAMGGFEKPILHGLCSFGFSARHVLKHFANNDVTKFKAIKVRFAKPVLPGQTLQTEMWKEGNRIFLQTKVKDTGEIAIAGAYVDLT 539          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDE--NTNKTEN-VPKSLEELIGKCRTTKLDKI----TFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFD-LLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDAN 1934
            + + L F+  V +VTG+GGGLGR YAL  A+RGA V++NDLG    G G   S A+KVV E++  GG A  NYDSV  GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ QN+GRI+ TSS+SGIYGNFGQ+NYSAAKLG++GLCNTL++EG K NI CNTIAP AGSR+TE V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K++  +T E VRD+W++I DFS +  P + +ES    V++L     E  + N+T +  P +    +G     KL       T   SI+YA+ VG +    ++LKF+YE  ++FS LPT+ VI    ++ +  L E+    +  + ++ LHGEQYLE++KP+    +    A I D+LDK  G V++++   + + KELI   QFS+++ G+GGF GK+ S+K   + A+P+R PDA++      NQA LYRL+GD NPLH+DP+F+ + GF+KPILHGLC+FG  ++  +  FAD +  +FK IKVRF+KPV PGQTL TE WK+   ++ Q K+ ETG + +S  Y++   A+
Sbjct:    1 MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGKGSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVR-KRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLHKVDSEGISPNRTSHAAPAATSGFVGAV-GHKLPSFSSSYTELQSIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVP--GLSFNFAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSY-SGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLNQAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPAS 608          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDL---------GVLR-----------------DGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACA---IKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V ++TG+G GLGR +ALE A+R A +V+ D+         G++R                  G+   L P N  V          +     V   EN+   A    KE G++ +L+NNAG++     +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G+VG   +LS E     K  IK   + P         G R+ +++ P      LKP+Y
Sbjct:   38 VCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGKGEEEILPPCNLQV----------FTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLKPDY 271          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDS----VVDG-------ENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHM-RNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            + ++L     +A+VTG+G G+GR  ++ LA  GA V   DL      DG       +++    +  G     + +    V  G       E + AC  +      ++++ AGI RD+  +H+S +DW+RVI V+L G +  T++A   +  +   G II  SS  G  GN GQ+NY+++K G++GL  T + E  ++ I+CN++ P
Sbjct:    1 MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDL------DGAAAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSR---PPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLP 197          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDS----VVDG-------ENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHM-RNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            + ++L     +A+VTG+G G+GR  ++ LA  GA V   DL      DG       +++    +  G     + +    V  G       E + AC  +      ++++ AGI RD+  +H+S +DW+RVI V+L G +  T++A   +  +   G II  SS  G  GN GQ+NY+++K G++GL  T + E  ++ I+CN++ P
Sbjct:    1 MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDL------DGAAAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSR---PPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLP 197          

Query:  156 VVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANK-----VVNEVKAFGGIAY---PNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            VVTG   G+G+  A+E  K+GA + +    V R+ D   L  A K      +N+ +    I+     +Y+ V   EN+I  A ++ G +D+L+N AG      F  +    + ++++++  G+   +++  T M+ +  GRI+F SS +G  G FG + YS++K  + GL   L +E   YN+      P
Sbjct:   36 VVTGGSSGIGKCIAIECYKQGAFITL----VARNED--KLLQAKKDIEKHSINDKQVVLCISVDVSQDYNQV---ENVIKQAQEKLGPVDMLVNCAGTSMSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYP 216          

Query:  126 TKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQ---TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVF-DLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            + L F+  V +VTG+G GLGR YAL  A+RGA VV+NDLG    G G     A+KVV E++  GG A  NYDSV +GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ Q +GRII TSS+SGIYGNFGQ+NYSAAKLGL+GL N+L++EG K NI CNTIAP AGSR+T+ V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K H + T E V+ +W +I DF  +  P S +ES  + +++L    +E   + N T     +           KL   ++      +I+YA+ VG +    ++LKF+YE  S+FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    K    A + DVLDK  G V++++   + ++KELI   QFSL++ G+GGF GK+ SDK   + A+P+R PDA++      NQA LYRL+GD NPLH+DP F+ L GF KPILHGLC+FG  +++ +  FAD +  +FK IK RF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:    3 SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPM-TPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIP--GLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSY-SEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 605          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDE--NTNKTEN-VPKSLEELIGKCRTTKLDKI----TFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFD-LLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDAN 1934
            + + L F+  V +VTG+GGGLGR YAL  A+RGA V++NDLG    G G   S A+KVV E++  GG A  NYDSV  GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ QN+GRI+ TSS+SGIYGNFGQ+NYSAAKLG++GLCNTL++EG K NI CNTIAP AGSR+TE V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K++  +T E VRD+W++I DFS +  P + +ES    V++L     E  + N+T +  P +    +G     KL       T   SI+YA+ VG +    ++LKF+YE  ++FS LPT+ VI    ++ +  L E+    +  + ++ LHGEQYLE++KP+    +    A I D+LDK  G V++++   + + KELI   QFS+++ G+GGF GK+ S+K   + A+P+R PDA++      NQA LYRL+GD NPLH+DP+F+ + GF+KPILHGLC+FG  ++  +  FAD +  +FK IKVRF+KPV PGQTL TE WK+   ++ Q K+ ETG + +S  Y++   A+
Sbjct:    1 MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGDFKGIGKGSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFGQANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVR-KRNQPMTPEAVRDNWEKICDFSNASKPQTIQESTGGIVEVLHKVDSEGISPNRTSHAAPAATSGFVGAV-GHKLPSFSSSYTELQSIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAEVP--GLSFNFAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSY-SGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLNQAALYRLSGDWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPAS 608          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDE--NTNKTENVPKS----LEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFD-LLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            + + L F+  V +VTG+GGGLGR YAL  A+RGA VV+NDLG    G G   S A+KVV E++  GG A  NYDSV  GE ++  A+  FG+ID+++NNAGILRD+SF  IS++DW+ +  VHL G+++ T++AW HM+ QN+GRII T+S+SGIYGNFGQ+NYSAAKLGL+GL NTL +EG K NI CNTIAP AGSR+TE V P +L EALKPEYV+PLVL+LCH S EE+G LFEVGAGW+GK+RWE + G +++ K++  +T E VRD+W +I DFS +  P S +ES    +++L     E  + N T  V  +       ++G    +     T    I+YA+ VG +    ++LKF+YE  ++FS LPT+ VI    ++    L E+    + I+ +++LHGEQYLE++KP+    +    A I D+LDK  G V++++   + + KELI   QFS+++ G+GGF GK+ S+K   + A+P R PDA++      NQA LYRL+GD NPLH+DP F+ + GF+KPILHGLC+FG  ++  +  FAD +  +FK IKVRF+KPV PGQTL TE WK+   ++ Q K++ETG I +S  Y++ 
Sbjct:    1 MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKVVEEIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSRMTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVR-KRNQPMTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVGHKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSLMSGGLAEVP--GLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSY-SGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPSRPPDAVLRDTTSLNQAALYRLSGDSNPLHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 604          

Query:  129 KLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNS--ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIA--CFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKS-DKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIK 1940
            KL ++  VAVVTG+G GLGR YAL  A+RGAKVV+NDLG    GDG     A+ VV+E++  GG A  +Y+SV+DG  +I  AIK FG++DIL+NNAGILRD+S V  S  DWN V +VHL G++K T++A+ +M+ QN+GRII TSS+SGIYGNFGQ NY+AAK+GL+GL NT+++EGA+ N+ CN I P A SR+TE + P  LF  LKP+ ++P+V YLCH S E++GS  E  AGW  K+     +G +L+    + VT+E V+D W  +TD S+++H  +  E+    +++L+   +   +  E                  D   F +   I YA+ +G +    ++++FLYEN ++F+ +PT+ V+         D L   +  +  +D S ILHGEQYLE+   +       T  ++ DV+DK  GAVV+ N+   +    L+ + Q + +I GAG F GKK       P +  P+R+PDA ++     +QA LYRL+GD NPLH+DP+ + L GFK PILHGLC+ G   +  +  FAD N   FK +KVRFS PVIPGQTL  + WK    +  +  + ETG   +SG Y++   +  K
Sbjct:    7 KLRYDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESCEDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGTLLEVLEKLKEGGGDAIE------------------DAFEFNSKELITYALGIGASVKNAKDMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSGTLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKKDPIAGVVPLQPAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQFADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDLKSSQAK 597          

Query:  129 KLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPS--SEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDF-SQSRHPSSNKESMQNYVDMLQTELDEN-TNKTENVPKSLEELIGKCRTTKLD------KITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHK-PIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHN--TKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKAL---PDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            K+ F   VA+VTG G G+GR Y L  A+ GA VV+NDL          ++P + VVNE+K  GG A     S  DG+ ++  AI  FG++DI++NNAGILRDK+F ++ +  W+ V+NVH  G YK TK+AW +   Q +GR++ T+S+SGIYGNFGQ+NYSAAK  ++G    ++LEGAKYNI  NTIAP AG+ +T+ + P EL +A KP+YV+PLVL LC      + +G L+EVG+GW G+ RW+ S G          +T E+V  HW++I  F S++ HP    +S++  +  ++  + E  +   EN     E L    + T ++        T ++  LY + +G   +K  ++K+++E + +F V+PT+ VI  FN   ++     D         +LHGEQYLE+ K PI    +  +  ++++V+DK   A+V    T  N  T +EL    + ++++ G GGF G+KK      S A    P R PDA++E      QA +YRL+GD NPLHVDP F+K+ GFK PILHGLCSFGI  +     +      KFK IKVRF+  V PGQTL+TE WK+   V  Q K+KETG + +SG   E 
Sbjct:  309 KVDFKGRVALVTGGGAGIGRAYCLAFARAGASVVVNDL----------VNP-DDVVNEIKKMGGKAVGAKFSAEDGDAVVKAAIDAFGRVDIVVNNAGILRDKAFHNMDDSLWDPVMNVHARGTYKVTKAAWPYFLKQKYGRVLNTTSTSGIYGNFGQANYSAAKCAILGFSRAIALEGAKYNIYVNTIAPNAGTAMTKTILPEELVQAFKPDYVAPLVLALCSDKVPKKPTGGLYEVGSGWCGQTRWQRSGGHGFPVDVP--LTPEEVVKHWNDIVTFDSRADHPEKASDSIEKIMANMENRVGEGKSGAAEN-----EHLAAIKKFTGVEGKGTEYTFTERDVCLYNLGIG---AKRTDIKYIFEGNEDFEVVPTFGVIPPFNT--EMPFSFDDIVPNFSPMMLLHGEQYLEVRKYPIPTSGRLVSKGKLLEVVDKGSAAIVKQGITTFNAETGEELFYN-EMTVFLRGCGGFGGQKKPADRGASTAANKPPARSPDAVVEVQTTEEQAAIYRLSGDYNPLHVDPAFAKVGGFKVPILHGLCSFGIAGKAVYEKYG-----KFKNIKVRFAGTVNPGQTLVTEMWKEGNKVVFQTKVKETGKLAISGAAAEL 893          

Query:  186 RTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHP-SSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPS 980
            + Y L    RGA VV+NDLG    G+GN    A+ VVNE+KA GG A  NYDSV +G+ II  AIKEFG+IDILINNAGILRD SF ++ ++DW+ +  VH+ G+YKT ++AW + R Q FGR+I T+S++G++GNFGQ+NYSAAKLG+VG   TL+ EG KYNI  N IAP+A SR+TE V PP+L   +KPE+V PLV  L H  ++ E+GS+FEVG G V K+RWE S G+LLK  +    T   +   WD++TDFS  ++P+
Sbjct:   23 KAYCLFFGSRGASVVVNDLGASFKGEGNSTKAADVVVNEIKAAGGKAVANYDSVENGDKIIETAIKEFGRIDILINNAGILRDISFKNMKDEDWDLIFKVHVKGSYKTARAAWPYFRKQKFGRVINTASAAGLFGNFGQANYSAAKLGMVGFTETLAKEGLKYNIISNVIAPIAASRMTETVMPPDLLALMKPEWVVPLVAVLVHKNNTSETGSIFEVGGGHVAKLRWERSSGLLLKADES--YTPGAIIKKWDQVTDFSNPQYPT 286          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQT-----ELDENTNKTENVPKSLEEL-----IGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFD-LLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L FN  V +VTG+GGGLGR YAL  A RGA VV+NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+IDI++NNAGILRD+SFV  S+ DW+ +  VHL G++  +++AW HM+NQNFGRII T+S++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP+AGSRLTE V PP+L  +LKPEYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S+G +L+ K   + T E VRD WDEI DF+ +  P++ +ES+ ++V++L       E+  N         S   +     +G+   +     T    ILYA+ VG++    ++L+FLYE H +FS LPT+ VI   +++ D  L+ +   D  ID +++LHGEQYLE+++P+    +  + A + DVLDK  GAV+L++   + + KEL+   QFSL++ GAGGF  K+ SDK  P    P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFKKPILHGLCSFG   +  +  FAD +  +FK IKVRF+KPV PGQ+L TE WK+   +++QCK+KETG + L+G Y++ +
Sbjct:    3 LSFNGRVVLVTGAGGGLGREYALAFAARGASVVVNDLGADTKGGGKSSAAADKVVEEIRAKGGKAVANYDSVEDGEKLIQSALDAFGRIDIVVNNAGILRDRSFVRTSDLDWDLIQRVHLRGSFLVSRAAWNHMKNQNFGRIIMTASAAGIYGNFGQANYSAAKLGMLGLANTLAIEGRKYNIHCNTIAPIAGSRLTETVMPPDLVASLKPEYVAPLVLWLCHEQCQENGGLFEVGAGWIGKLRWERSQGRILRQKSKPM-TPEAVRDQWDEICDFTNATKPTTIQESLASFVNVLSQVESGGEVGANPAAASASAASDAGINPTLAVGQKLPSSSFSYTHTQCILYALGVGMSTKDPDHLRFLYEGHPDFSCLPTFGVIPSQSSIMDGGLSSVPGLD--IDFTRVLHGEQYLELYRPLPTSGELISEATVADVLDKGSGAVILLDVNTY-SGKELVCYNQFSLFVVGAGGFGVKRNSDKAKPPLPPPNRAPDAVVIDSTTRDQAALYRLSGDWNPLHIDPSFAAMGGFKKPILHGLCSFGFAGRHVLKRFADNDPSRFKAIKVRFAKPVSPGQSLQTEMWKEGNRIHIQCKVKETGDVVLAGAYVDLH 607          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTELDENTNKTENVPKSLEELIGKCRTT----KLDKITFQNS----ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGR YAL  A RGA VV+NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+IDI++NNAGILRD+SFV  S+ DW+ +  VHL G++  +++AW HM+NQNFGRII T+S++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP+AGSRLTE V PP+L  +LKPEYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S+G +L+ K   + T E VRD W EI DF+ +  P++ +ES+ ++V +L Q E  E          S+    G   T     KL   +F  S    ILYA+ VG++    ++L+FLYE H +FS LPT+ VI   +++ D    LS    + ID +++LHGEQYLE++KP+    +  + A + DVLDK  GAV+L++   + + KEL+   QFS+++ GAGGF  K+ SDK  P    P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFKKPILHGLCSFG   +  +  FAD +  +FK IKVRF+KPV PGQ+L TE WK+   +++QCK+KETG + L+G Y++ +
Sbjct:    3 LSFDGRVVLVTGAGGGLGREYALAFAARGASVVVNDLGADTKGGGKSSAAADKVVEEIRAKGGKAVANYDSVEDGEKLIQSALDAFGRIDIVVNNAGILRDRSFVRTSDLDWDLIHRVHLRGSFLVSRAAWNHMKNQNFGRIIMTASAAGIYGNFGQANYSAAKLGMLGLANTLAIEGRKYNIHCNTIAPIAGSRLTETVMPPDLVASLKPEYVAPLVLWLCHEQCQENGGLFEVGAGWIGKLRWERSQGRILRQKSKPM-TPEGVRDQWKEICDFTNATKPTTIQESLASFVTVLSQVESGEVGANPAAAATSVASDAGINPTMAVGQKLPTSSFSYSHTQCILYALGVGMSTKDPDHLRFLYEGHPDFSCLPTFGVIPSQSSIMD--GGLSSVPGLNIDFTRVLHGEQYLELYKPLPTSGELISEATVADVLDKGSGAVILLDVNTY-SGKELVCYNQFSVFVVGAGGFGVKRNSDKAKPPLPPPNRAPDAVVIDSTTRDQAALYRLSGDWNPLHIDPSFAAMGGFKKPILHGLCSFGFAGRHVLKQFADNDPSRFKAIKVRFAKPVTPGQSLQTEMWKEGNRIHIQCKVKETGEVVLTGAYVDLH 606          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTELDENTNKTENVPKSLEELIGKCRTT----KLDKITFQNS----ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGR YAL  A RGA VV+NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+IDI++NNAGILRD+SFV  S+ DW+ +  VHL G++  +++AW HM+NQNFGRII T+S++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP+AGSRLTE V PP+L  +LKPEYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S+G +L+ K   + T E VRD W EI DF+ +  P++ +ES+ ++V +L Q E  E          S+    G   T     KL   +F  S    ILYA+ VG++    ++L+FLYE H +FS LPT+ VI   +++ D    LS    + ID +++LHGEQYLE++KP+    +  + A + DVLDK  GAV+L++   + + KEL+   QFS+++ GAGGF  K+ SDK  P    P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFKKPILHGLCSFG   +  +  FAD +  +FK IKVRF+KPV PGQ+L TE WK+   +++QCK+KETG + L+G Y++ +
Sbjct:    3 LSFDGRVVLVTGAGGGLGREYALAFAARGASVVVNDLGADTKGGGKSSAAADKVVEEIRAKGGKAVANYDSVEDGEKLIQSALDAFGRIDIVVNNAGILRDRSFVRTSDLDWDLIHRVHLRGSFLVSRAAWNHMKNQNFGRIIMTASAAGIYGNFGQANYSAAKLGMLGLANTLAIEGRKYNIHCNTIAPIAGSRLTETVMPPDLVASLKPEYVAPLVLWLCHDQCQENGGLFEVGAGWIGKLRWERSQGRILRQKSKPM-TPEAVRDQWKEICDFTNATKPTTIQESLASFVTVLSQVESGEVGANPAAAATSVASDAGINPTMAVGQKLPTSSFSYSHTQCILYALGVGMSTKDPDHLRFLYEGHPDFSCLPTFGVIPSQSSMMD--GGLSSVPGLNIDFTRVLHGEQYLELYKPLPTSGELISEATVADVLDKGSGAVILLDVNTY-SGKELVCYNQFSVFVVGAGGFGVKRNSDKAKPPLPPPNRAPDAVVIDSTTRDQAALYRLSGDWNPLHIDPSFAAMGGFKKPILHGLCSFGFAGRHVLKQFADNDPSRFKAIKVRFAKPVTPGQSLQTEMWKEGNRIHIQCKVKETGEVVLTGAYVDLH 606          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTE-----------------LDENTNKTENVPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFD-LLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGY 1913
            L F+  V +VTG+GGGLGR YAL  A RGA VV+NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+IDI++NNAGILRD+SFV  S+ DW+ +  VHL G++  +++AW HM+NQNFGRII T+S++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP+AGSRLTE V PP+L  +LKPEYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S+G +L+ K   + T E VRD WDEI DF+ +  P++ +ES+ ++V++L Q E                  D   N T  V + L         T     T    ILYA+ VG++    ++L+FLYE H +FS LPT+ VI   +++ D  L+ +   D  ID +++LHGEQYLE++KP+    +  + A + DVLDK  GAV+L++   + + KEL+   QFSL++ GAGGF  K+ SDK  P    P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFKKPILHGLCSFG   +  +  FAD +  +FK IKVRF+KPV PGQ+L TE WK+   +++QCK+KETG + L+G Y
Sbjct:    3 LSFDGRVVLVTGAGGGLGREYALAFAARGASVVVNDLGADTKGGGKSSAAADKVVEEIRAKGGKAVANYDSVEDGEKLIQSALDAFGRIDIVVNNAGILRDRSFVRTSDLDWDLIQRVHLRGSFLVSRAAWNHMKNQNFGRIIMTASAAGIYGNFGQANYSAAKLGMLGLANTLAIEGRKYNIHCNTIAPIAGSRLTETVMPPDLVASLKPEYVAPLVLWLCHEQCQENGGLFEVGAGWIGKLRWERSQGQILRQKSKPM-TPEAVRDQWDEICDFTNATKPTTIQESLASFVNVLSQVESGGEVGANPVAAAASAASDTGINPTMAVGQKL--------PTSSFSYTHTQCILYALGVGMSTKDPDHLRFLYEGHPDFSCLPTFGVIPSQSSIMDGGLSSVPGLD--IDFTRVLHGEQYLELYKPLPTSGELISEATVADVLDKGSGAVILLDVNTY-SGKELVCYNQFSLFVVGAGGFGVKRNSDKAKPPLPPPNRAPDAVVIDSTTRDQAALYRLSGDWNPLHIDPSFAAMGGFKKPILHGLCSFGFAGRHVLKQFADNDPSRFKAIKVRFAKPVSPGQSLQTEMWKEGNRIHIQCKVKETGDVVLTGAY 603          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDEN------TNKTENVPKSL--EELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDA 1931
            L F   V +VTG+GGGLGR YAL   +RGA VV+NDLG    G G   + A++VV E+K+ GG A  NYDSV DGE +I  A+  FG+IDI+INNAGILRD+SF   S+ DW+ +  VHL G++  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP AGSRLT+ V PP+L E+LK EYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S G +++ K  ++ + EDVRD WD+I +F+ +  P++ +ESM   VD+L     E       T+   +    +   E +GK         T  + ILYA+ VG++  +  +LKF+YE H  FS LPT+ VI    ++ D    LS    +  D +++LHGEQYLE++KP+      ++ A I D+LDK  GAV+L++   +N K+EL+   QFS++I GAGGF GK+ SDK   + A P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFK PILHGLCSFG  ++  +  +A  +  +FK IKVRF KPV+PGQ+L TE WK++  ++ QCK+KETG + LSG YI+ + A
Sbjct:    6 LSFARKVVLVTGAGGGLGREYALAFGERGASVVVNDLGGDIKGGGKSSAAADRVVEEIKSKGGRAVANYDSVEDGEKLIQTALDAFGRIDIVINNAGILRDRSFARTSDLDWDLIHRVHLRGSFLVTRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGILGLANTLAIEGQKYNIHCNTIAPTAGSRLTQTVMPPDLVESLKAEYVAPLVLWLCHEECQENGGLFEVGAGWIGKLRWERSLGSIVRHKNQSM-SPEDVRDKWDQICNFTNAAKPATIQESMHLLVDVLSKVEAEKGIGALPTSAVTSASSGINPAEAVGKVLPEMTFSYTNMHCILYALGVGMSTRESNHLKFIYEGHEEFSCLPTFGVIPAQASMLD--GGLSSIPGLNFDPTRLLHGEQYLELYKPLPTSGTLTSKASIADILDKGSGAVILLDVYTYN-KQELVCYNQFSVFIVGAGGFGGKRASDKAVATVAPPNRSPDAVLVDETTRDQAALYRLSGDWNPLHIDPSFAAMGGFKSPILHGLCSFGFAARHVLRQYAGNDVSRFKSIKVRFVKPVLPGQSLQTEMWKEENRIHFQCKVKETGDVALSGAYIDLHAA 610          

Query:  186 RTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTT-----KLDKITF----QNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDA 1931
            R YAL   +RGA VV+NDLG    G G   + A+KVV E+KA GG A  NYDSV DGE +I  A+  FG+IDIL+NNAGILRD+SF   S+ DW+ +  VHL G++  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGL+GL NTL++EG KYNI CNTIAP AGSRLT+ V PP+L E+LK EYV+PLVL+LCH   +ESG LFEVGAGW+GK+RWE + G +++ K  ++ + E+VRD WD+I DF+ +  P++  ES+Q  V++L + +D       N   +L         T      L ++TF      SILYA+ VG++  + ++LKFLYE H +FS LPT+ VI    ++ +    LS    +  D +++LHGEQYLE++KP+      ++ A I DVLDK  GAV+L++   + +K+EL+   QFS++I G+GGF GK+ SDK  P+   P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFK PILHGLCSFG  ++  +  +AD +  KFK IKVRF KPV+PG+++ TE WK+   +++ CK+KE+G + LSG YI+ + A
Sbjct:   23 REYALAFGERGASVVVNDLGGDIKGGGKSSAAADKVVEEIKAKGGKAVANYDSVEDGEKLIQTALDAFGRIDILVNNAGILRDRSFARTSDLDWDLIHRVHLRGSFLVTRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLLGLANTLAIEGRKYNIHCNTIAPTAGSRLTQTVMPPDLLESLKAEYVAPLVLWLCHEECQESGGLFEVGAGWIGKLRWERTVGSIVRHKDQSM-SPEEVRDKWDQICDFNNATKPATINESLQTLVEVL-SAVDTGDAIRANPTSALSPADSGINPTLAVGAVLPEMTFTYTPMRSILYALGVGMSTKEPDHLKFLYEGHEDFSCLPTFGVIPAQASMME--GGLSTVPGLNFDPTRLLHGEQYLELYKPLPTSGTLTSKASIADVLDKGSGAVILLDVHTY-SKQELVCYNQFSVFIVGSGGFGGKRSSDKAVPTVPPPNRAPDAVMVDKTSRDQAALYRLSGDWNPLHIDPSFAAMGGFKTPILHGLCSFGFAARHVLKHYADNDVSKFKSIKVRFVKPVLPGESIQTEMWKEGNRIHLVCKVKESGAVVLSGAYIDLHAA 609          

Query:  186 RTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTT-----KLDKITF----QNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDA 1931
            R YAL   +RGA VV+NDLG    G G   + A+KVV E+KA GG A  NYDSV DGE +I  A+  FG+I  +     ILRD+SF   S+ DW+ +  VHL G++  T++AW HM+NQ FGRII TSS++GIYGNFGQ+NYSAAKLGL+GL NTL++EG KYNI CNTIAP AGSRLT+ V PP+L E+LK EYV+PLVL+LCH   +ESG LFEVGAGW+GK+RWE + G +++ K  ++ + E+VRD WD+I DF+ +  P++  ES+Q  V++L + +D       N   +L         T      L ++TF      SILYA+ VG++  + ++LKFLYE H +FS LPT+ VI    ++ +    LS    +  D +++LHGEQYLE++KP+      ++ A I DVLDK  GAV+L++   + +K+EL+   QFS++I G+GGF GK+ SDK  P+   P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFK PILHGLCSFG  ++  +  +AD +  KFK IKVRF KPV+PG+++ TE WK+   +++ CK+KE+G + LSG YI+ + A
Sbjct:   23 REYALAFGERGASVVVNDLGGDIKGGGKSSAAADKVVEEIKAKGGKAVANYDSVEDGEKLIQTALDAFGRIGTIFM---ILRDRSFARTSDLDWDLIHRVHLRGSFLVTRAAWNHMKNQKFGRIIMTSSAAGIYGNFGQANYSAAKLGLLGLANTLAIEGRKYNIHCNTIAPTAGSRLTQTVMPPDLLESLKAEYVAPLVLWLCHEECQESGGLFEVGAGWIGKLRWERTVGSIVRHKDQSM-SPEEVRDKWDQICDFNNATKPATINESLQTLVEVL-SAVDTGDAIRANPTSALSPADSGINPTLAVGAVLPEMTFTYTPMRSILYALGVGMSTKEPDHLKFLYEGHEDFSCLPTFGVIPAQASMME--GGLSTVPGLNFDPTRLLHGEQYLELYKPLPTSGTLTSKASIADVLDKGSGAVILLDVHTY-SKQELVCYNQFSVFIVGSGGFGGKRSSDKAVPTVPPPNRAPDAVMVDKTSRDQAALYRLSGDWNPLHIDPSFAAMGGFKTPILHGLCSFGFAARHVLKHYADNDVSKFKSIKVRFVKPVLPGESIQTEMWKEGNRIHLVCKVKESGAVVLSGAYIDLHAA 606          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLG-------------VLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACA---IKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V V+TG+GG LGR +A E A+R A +V+ D+              + R+ D     P ++   E   F    Y     V   E++ + A    +E G++D+LINNAG++     +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G +G   +LS E     K  IK   + P         G R+ +++ P      L+PE+
Sbjct:   39 VCVITGAGGELGRLFAREFARRRATLVLWDINSTSNEETAEMVREIYRELDTQTEGPGSE---EGSTFQPQVYTYVCDVGKRESVYSTAERVRREVGEVDLLINNAGVVSGHHLLECPDELIERTMVVNCHAHFWTTKAFLPKMLEMNHGHIVTVASSLGLFSTAGVEDYCASKFGAIGFHESLSHEIKASEKDGIKMTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLRPEF 266          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLG---------VLRD-----------GDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYN---IKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V VVTG+G GLGR +A E A+R A +V+ D+          ++RD           GDG         V +V  +    Y     V   E++ + A K   E G +  LINNAG++     +   ++   R + V+ H  + TTK+    M + N G I+  +SS G++   G  +Y A+K G +G   +LS E    N   IK   + P         G ++ +++ P   F  LKPEY
Sbjct:   38 VCVVTGAGSGLGRLFATEFARRRATLVLWDINREANEETAELVRDIYRETEPRRGSGDG---------VEDVPFYQPRVYTYVCDVSKRESVYSTAEKVRQEVGNVTFLINNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPKMLDLNHGHIVTVASSLGLFTTAGVEDYCASKFGAIGFHESLSHELKAANKDGIKMTLVCPFLVDTGMFQGCKIRKEIAP--FFPPLKPEY 266          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEV--KAFGGIAYP-NYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSN--YSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            ++++L  +  VA VTG+G G+GR +A  L + GAKV I D+         D + A +V +E+  K    +A   +     D + +I   I ++G + I  NNAGI  + +    + D+W++  NV+L G +   ++A   M  Q +G+II T+S + +     Q    Y+ +K G+V L  TL  E     ++ N I+P
Sbjct:  297 ILSRLRLDGKVAYVTGAGQGIGRAFAHALGEAGAKVAIVDI---------DKTKAERVTHELTLKGICSMALAADISRAEDVQQMIDSIISKWGGVHIACNNAGINMNSASEDTALDEWDQTFNVNLRGTFMCCQAAGRVMLKQGYGKIINTASMASLIVPHPQKQLAYNTSKAGVVKLTQTLGTEWIDRGVRVNCISP 486          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYD---SVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEE-----------LIGKCRTTKLDKITFQ----NSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINAT---IHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEF 1922
            +M +L F+  V +VTG+GGGLG+ YAL  A+RGA VV+NDLG    G+G   S ANKVV E+   GG A  N+D   SV DGE +I  A+  +G+ID+++NNAGILRD++F  IS+ DW+ +  VHL G++  T++AW HM+NQ +GRII TSSSSGIYGNFGQ+NYSAAK+GL+GL NT+++EG KYN+ CNT+AP AGSRLT+ V P EL +ALKPE+V+PL+L+LCH S +++G++FEVGAGWVGK+RWE S G +L+TK   + T E VRD+W ++ DF+ S HP S++ES   Y+D+L+ ++DE    +  VP S              L G+    K+    ++      ILY++ VG++ S      FLYE H +FS LPT+ VI        +  +LS+   +  + ++ LHGE YLE+ KP+    K    A I DVLDK  G ++L++A     +N  KE I   QFS+++ GAGGF GK+ SDK  P+ A+P R PDA +      +QA LYRL+GD NPLH+DPEFS + GFK+PILHGLCSFG  ++  +  +A+ ++ KFK IK RF+KPV+PGQTL T+ WK+   V+ Q K+ ETG + L+  Y++ 
Sbjct:    1 IMAQLRFDGRVVLVTGAGGGLGKEYALAFAERGALVVVNDLGGDIKGEGKSTSAANKVVQEILTKGGKAVANHDQTDSVEDGEKLIKSALDAYGRIDVVVNNAGILRDRTFPRISDQDWDIIQRVHLRGSFLVTRAAWNHMKNQKYGRIIMTSSSSGIYGNFGQANYSAAKMGLLGLSNTIAIEGQKYNVHCNTVAPTAGSRLTQSVMPQELVDALKPEFVAPLILWLCHESCQDTGNIFEVGAGWVGKLRWERSNGAILRTKGKPM-TPEAVRDNWGKVCDFTDSTHPKSSQESTIMYLDVLR-KIDEQQGISP-VPASGTSVGKVSTIFSTVLYGQAVGFKMPPFVYEYTWLQPILYSLGVGMSTSYDGGRVFLYEGHQDFSCLPTFGVIPA--QAILMNGQLSNVPGLSFEPAKSLHGEHYLEIFKPLPTSGKMIVEATIADVLDKGSGCLLLLDALTVYTYNENKEPICFNQFSVFVVGAGGFGGKRSSDKVKPTVAIPKRSPDASVTDKTSLDQAALYRLSGDWNPLHIDPEFSAVVGFKQPILHGLCSFGFSARHVLKQYANNDTSKFKAIKARFAKPVLPGQTLQTDMWKEGSRVFFQTKVVETGEVVLANAYVDL 618          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLG----------VLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEG---AKYNIKCNTIAP 701
            V +VTG+G GLGR  AL LA+ GA +VI D+           +  +GDG +    N     V A+  +     D V    +++   +++ G IDIL+NNAGI+  + F+   ++   + ++V++   + T K+    M   + G ++  +SS+G+ G  G ++Y A+K   VG   +++LE     K+ +K   + P
Sbjct:   42 VVLVTGAGSGLGRLVALSLARLGATLVIWDVNRAANEETAQLIREEGDGVE---GNGRKPSVHAYS-VDCSRRDDVYRVADLV---MRDVGDIDILVNNAGIVTGRKFIDSPDELLQKTMDVNIMAHFWTYKAFLPAMVANDHGHLVSIASSAGLIGVNGLADYCASKFAAVGFAESVALEMLALGKFGVKTTIVCP 231          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRII-FTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP--VAGSRLTEDV-FPPELFEA-------------LKPEYVSPLVLYLCHPSSEES----GSLFEVGAGW 848
            V V+T +G G+GR  A+  AK GAKV+  D+               + + E++   GI     + V   + I A A K   K+D+L N AG +   + +   + DW+  +N+++ G Y   ++    M  Q  G II   S +S I G   +  YS +K  ++GL  +++ +     I+CN + P  V    L E +   P+  +A              KPE V+ L +YL   +S+ES    G+   +  GW
Sbjct:    8 VVVLTAAGQGIGRACAIAFAKEGAKVIATDIN-------------GEALKELEQIPGIEVGVLN-VTSKDQIEALAAK-IDKVDVLFNCAGFVHHGTILDCEDKDWDFTMNLNVKGMYYMIRAFLPKMLAQKSGSIINMASVASSIKGVANRCVYSTSKAAIIGLTKSVAADFLTEGIRCNAVCPGTVDTPSLQERINAQPDPEKARQDFMARQKSGRLAKPEEVAHLCVYL---ASDESAYVTGNEMVIDGGW 243          

Query:  159 VTGSGGGLGRTYALELAKRGAKVVI---NDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNI 680
            VTG   G+G+  A+E  ++GA V +   N+  +L+     +      VVNE +A   I+    +     E++I  A ++ G +D+L+N AG      F  I   ++ R++ V+  G+  T+ +    M+ +  GR+++ SS +G  G +G + YS  K  L GL   L +E   YN+
Sbjct:    4 VTGGSSGIGKAIAIECVRQGACVTLVARNEAKLLQAKREAE----EHVVNESQAVLCISVDVSNDFNQVESVIKQAQEKLGPVDMLVNAAGTSVAGRFEDIKPQEFKRLMEVNYLGSVFTSLAVVPGMKERRKGRVVYVSSQAGQLGLYGFTAYSPTKFALRGLAEALQMEVKPYNV 176          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGI-LRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVA-----GSRLTEDVFPPELF-------EALKPEYVSPLVLYLC 797
            +AVVTGS  G+G   A  LA+ GA VV++        + +    A ++  E     GI     D+      +I   + + G +DIL+ NA +       ++ + + W++V++V+L   +   K A  HM+ +  G ++F SS +  + N     Y  +K  L+GL   LS   A  NI+ N +AP        + LT+D    ++F        A  PE V+ LV +LC
Sbjct:   34 IAVVTGSTYGIGLAIARRLAQHGAHVVVSS-----RTEEHVAHAAEELHAEGLNVTGIVCHVGDAD-QRTKLIKETVSKLGGLDILVLNAAVNPYVGPLLNATAEVWDKVLDVNLKAPFLFVKEAAPHMKERGEGAVVFISSVTAYFPNEDIGPYCVSKTALLGLTKALSRPLAAMNIRVNNVAPGLIETGFSAGLTKDEKMMQMFRNVTAIPRAGYPEEVASLVSFLC 256          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSV-VDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITD-----FSQSRHP 977
            L F D V V+TG+GGGLG+ YAL  A RGAKVV+NDLG    G G++   A+ VV+E+K  GGIA  NYDSV  +GE II  AIKEFG++D+LINNAGILRD SF  ++  ++  V++VHL G YK +++AW +MR+Q FGRII T+S +G++GNFGQ+NYSAAK+GLVGL  TL+ EGAKYNI  N+IAP+A SR+TE+V PP + + L PE + PLVLYL H S++ S S+FE+ AG+ G++RWE S G +         T E + + W EITD     F++++HP
Sbjct:    5 LSFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVVDVHLTGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLYLTHESTKVSNSIFELAAGFFGQLRWERSSGQIFNPDPKT-YTPEAILNKWKEITDYRDKPFNKTQHP 291          

Query:  186 RTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEV-KAFG-GIAYPN-YDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFP-PELFEALKPEYVSPLVLYLCHPSSEES------GSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSR-HPSSNKESMQNYVDMLQ-----TELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDL-LNELSDHDVGIDLSQILHGEQYLEMHKP-IRIDEKYSTTAEIVDVLDKIRGAVVLINA--TIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPD------RKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIK 1940
            +++A+  A+ GAKVV+ND+   +D           VV E+ K +G G A P+ +D V +   II  AI +F ++DIL+NNAGILRDKSF+ + +++W  V+ VHL   +  +K+ W     Q  G II T+S+SGIYGNFGQ+NY+AAK  ++G   T++LEGAK  I  N IAP A + +T+ +F   EL        VSPLV+ L     ++       G LFEVG GW G+ RW+ S G +        +  E+++++W+ ITDFS++  +PSS +ES    +  +Q      ELD+                       L K T ++ ILY + +G  +   + LK+ YEN  +F VLPT+AVI        L ++ L D+    + + +LHGEQY ++  P +  +    T A+ + VLDK   A +++    T     K+LI+  + S +I GA     K+  D +    A+ +      + PD   E   + +QA LYRL+GD NPLH+DP  +K   F  PILHGLC+ GI ++     +       ++++KVRF+  V PG TL  + WK   +V  Q        I L    ++ + A  K
Sbjct:  336 KSHAIWFARYGAKVVVNDI---KD--------PFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVIGQLFEVGGGWCGQTRWQRSSGYV---SIKETIEPEEIKENWNHITDFSRNTINPSSTEESSMATLQAVQKAHSSKELDDG----------------------LFKYTTKDCILYNLGLGCTS---KELKYTYENDPDFQVLPTFAVIPFMQATATLAMDNLVDN---FNYAMLLHGEQYFKLCTPTMPSNGTLKTLAKPLQVLDKNGKAALVVGGFETYDIKTKKLIAYNEGSFFIRGAHVPPEKEVRDGKRAKFAVQNFEVPHGKVPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKAVKFPTPILHGLCTLGISAKALFEHYG-----PYEELKVRFTNVVFPGDTLKVKAWKQGSVVVFQTIDTTRNVIVLDNAAVKLSQAKSK 899          

Query:  135 LFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGND-----LSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVA 707
            LF   VA VTG  G + R     L   G K  I    V RD +  +     +S   K  + V A   +   N++ V   EN +   +++FGKID +I  A       F ++S + +  V+++ L G++ T K+    ++    G I+F S++   YG   Q +  AAK G+  L   L++E     I+ N IAP A
Sbjct:   21 LFKGKVAFVTGGAGTICRVQTEALVLLGCKAAI----VGRDQERTEQAAKGISQLAKDKDAVLAIANVDVRNFEQV---ENAVKKTVEKFGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSFNTAKACLKELKKSK-GSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIRSNCIAPGA 208          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNY-------DSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCN 689
            +L  +  A++TG   GLG   A EL++R  KV++ D                  +     F  + Y N         S+ + +N+     ++ G I+I+INNAG+   K   H++N +  ++I+++L GAY+   +    M +   G II  +S  G       ++Y A+K  ++G    +S      + +CN
Sbjct:   34 ILSKNATALITGGSSGLGFELAKELSRRINKVIVAD------------------IQSFPTFAQVEYNNIFYYQCDITSLDEIKNLKKAIERDHGNINIIINNAGVAHIKKLEHMTNKEVEQLIDINLIGAYRIISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECN 208          

Query:  138 FNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNSILYAISVGIN-NSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLL-NELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFND--ANIKP 1943
            F+  V +VTG+G GLGR YAL  A+RGA VV+NDLG    G+G     A+KVV E++A GG A  +Y+SV  G+ ++  AIK FG+ID+++NNAGILRDKS + +S  DW+ V  VHL G++  T++AW HM+ Q FGRII T+S+SGIYGNFGQ+NYSAAKLGLVGL NTL+ EGAKYNIKCN IAPVAGSRLT+ V   E+ EALKPEY++PLVLYLCH S EE+  LFE   GW  + RW+ ++G LL+ K+   VT E VRD+W+ ITD++ + +P+     +Q   D+ +   ++   +  +  KS+ + +   + +     T  + ILYA+ VG++      +LKFLYENH +F+ LPT+ +I    ++  +   E++   +  D +++LHGEQYLE++KP+      +  AE+VDVLDK +GA+VL+N T  + ++E I   QFS+Y+ GAGGF GK+ SDK  P  + P R PDA +++     QA LYRL+GD NPLHVDP F+++ G  KPILHGLCS G  ++  +  +A+ +  KFK +KVRFSKPV+PGQT+ T+ WK+   V+ Q K+ E GT+ +SG Y++F +   NI P
Sbjct:    8 FDGRVVLVTGAGNGLGRQYALAFAERGASVVVNDLGGDTKGEGKSGRAADKVVQEIRAKGGKAVADYNSVEQGDQVVETAIKAFGRIDVVVNNAGILRDKSILRMSELDWDLVQRVHLKGSFLVTRAAWPHMKKQKFGRIIMTTSTSGIYGNFGQANYSAAKLGLVGLSNTLAQEGAKYNIKCNAIAPVAGSRLTKTVMSDEMIEALKPEYIAPLVLYLCHESCEENAGLFETAVGWFSQTRWQRTKGKLLR-KEVEFVTPEMVRDNWEGITDWTDAENPTEASNVLQFVEDVKEARQEQENARNASPGKSMTQKMPDAKKS----YTHNDVILYALGVGVSFQEDYSHLKFLYENHEDFAALPTFGIILGQGSMMGIAGGEMA--GIKFDPAKLLHGEQYLEVYKPLPTSGSITNRAEVVDVLDKGKGALVLLNVTTLDEQEEPICFNQFSIYLGGAGGFGGKRSSDKVKPVVSPPSRTPDASVKEKTGLTQAALYRLSGDYNPLHVDPAFAQMGGLSKPILHGLCSLGYSARHVLKQYANNDVSKFKALKVRFSKPVVPGQTIQTDMWKEGSRVHFQSKVVENGTVVISGAYVDFTELTPNIPP 606          

Query:  135 LFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDL-GVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKID-ILINNAGILRDKSFVHISNDDWNRVINVHLHGAY---KTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP-VAGSRLTEDVFPPELFEALK----------PEYVSPLVLYL-CHPSSEESGSLFEVGAGW 848
            L    +A+VTG G G+GR     LA RGA V + DL GV       +L+  N               N  S  + ++++    KE+ +   IL+N+AGI +D   + +   D++ VI+V+L G +   +TT  A    +  N G II  SS     GN GQ+NY+A+K G+ GL    ++E A++ I+CN I P    + +T  V P  + E +K          P  ++ +V +L C  SS  +G+  +V  G 
Sbjct:    7 LLRGRLALVTGGGSGIGRAVCEALANRGASVSVIDLHGVGAKETSENLATHNDTTRHTHF-----AVNVASSSEVKDLLQAIHKEYQRAPCILVNSAGIAKDALLLKMKEQDFDDVIDVNLKGTFLMCQTTAKAMVENKINN-GSIINISSIVAKSGNMGQANYAASKAGVEGLTKVCAIELARFGIRCNAILPGFIDTPMTRKV-PAHITEQIKHFIPLGRFGQPSNIADVVSFLACDESSYITGASIDVTGGL 254          

Query:  156 VVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIA------YPNYDSVVDGENIIACAIKEFGK---IDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            +VTG   G+G     +L++       +D  +L +   N ++ A K + EV   GG          NYD V      +  A +E      ++ ++NNAGI RD  F+ +SN+DW  VIN  L+G +  T      M    +GRI+   S SG+ G  GQ+NYSAAK  +V     L+ E AK NI  N +AP
Sbjct:    5 LVTGGSRGIGSEICKKLSQE------SDYHILINYQANKVA-AEKTLEEVIKSGGTGEIIQFDVANYDEV----KAVLTAWQEANPEAIVEAIVNNAGITRDGLFMWMSNEDWTSVINTSLNGFFNVTNFFIQKMLRNKYGRIVNMVSVSGVKGTAGQANYSAAKGAIVAATKALAQEVAKRNITVNAVAP 184          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAPV---AGSRLTEDVFPPELFEALKPEYVS 776
            + ++TGSG GLGR  A   AK GA++V+ D+         DL+  ++    V+A G   +         E I A A +   E G +DIL+NNAGIL  K  +  ++    + I ++L   + T++S    M  QN G I+  SS SG +    Q  Y A+K G VG  + LS E     K  +K   + P     G      +   +L + L+P YV+
Sbjct:   38 IVLITGSGRGLGRLLAARFAKLGARLVLWDIN-------EDLN--HETAEVVEALGAEVHSYACDCTSREEIYATASRVKGEVGDVDILVNNAGILHGKRLLDQTDAQIQKAIELNLLAHFWTSRSFLGRMLEQNQGHIVTISSVSGSFPTAFQVEYCASKYGAVGFHDALSHELYTLGKDGVKTTLVQPFFFDTGISWYPKMRFQKLHKVLEPSYVA 246          

Query:  141 NDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLS-PANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDW--NRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGA---KYNIKCNTIAP 701
             D + ++TG+G G+G+  A+E AK GAK+V  D+    +   ND +    K +N+ KAFG     +  S  D   +     +E G++ IL+NNAGI+  K F  +  +DW   + + V+    + T KS    M  +N G ++  +SS+G +G  G  +Y ++K G VG   +L +E +   K  +K   + P
Sbjct:   36 QDEIVLITGAGSGIGKGMAIEFAKIGAKIVCVDI----NKQANDQTVEVIKSLNQ-KAFG--YKCDCSSREDIYRVADIVKREVGEVTILVNNAGIVSGKKF--LDTEDWMIQKTMEVNTMAHFWTVKSFLPSMLAKNHGHVVNIASSAGFFGVPGMCDYCSSKFGAVGFDESLRMELSSLGKTGVKTTVVCP 219          

Query:  132 LLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDML-QTELDENTNKTENVPKSLEELIGKCRTT----KLDKITFQNS----ILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSD-HDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFN 1925
            L F+  V +VTG+GGGLGR YAL  A RGA VV+NDLG    G G   + A+KVV E++A GG A  NYDSV DGE +I  A+  FG+IDI++NNAGILRD+SFV  S+ DW+ +  VHL G++  +++AW HM+NQNFGRII T+S++GIYGNFGQ+NYSAAKLG++GL NTL++EG KYNI CNTIAP+AGSRLTE V PP+L  +LKPEYV+PLVL+LCH   +E+G LFEVGAGW+GK+RWE S+G +L+ K   + T E VRD W EI DF+ +  P++ +ES+ ++V +L Q E  E          S+    G   T     KL   +F  S    ILYA+ VG++    ++L+FLYE H +FS LPT+ VI   +++ D    LS    + ID +++LHGEQYLE++KP+    +  + A + DVLDK  GAV+L++   + + KEL+   QFS+++ GAGGF  K+ SDK  P    P+R PDA++      +QA LYRL+GD NPLH+DP F+ + GFKKPILHGLCSFG   +  +  FAD +  +FK IKVRF+KPV PGQ+L TE WK+   +++QCK+KETG + L+G Y++ +
Sbjct:    3 LSFDGRVVLVTGAGGGLGREYALAFAARGASVVVNDLGADTKGGGKSSAAADKVVEEIRAKGGKAVANYDSVEDGEKLIQSALDAFGRIDIVVNNAGILRDRSFVRTSDLDWDLIHRVHLRGSFLVSRAAWNHMKNQNFGRIIMTASAAGIYGNFGQANYSAAKLGMLGLANTLAIEGRKYNIHCNTIAPIAGSRLTETVMPPDLVASLKPEYVAPLVLWLCHDQCQENGGLFEVGAGWIGKLRWERSQGRILRQKSKPM-TPEAVRDQWKEICDFTNATKPTTIQESLASFVTVLSQVESGEVGANPAAAATSVASDAGINPTMAVGQKLPTSSFSYSHTQCILYALGVGMSTKDPDHLRFLYEGHPDFSCLPTFGVIPSQSSMMD--GGLSSVPGLNIDFTRVLHGEQYLELYKPLPTSGELISEATVADVLDKGSGAVILLDVNTY-SGKELVCYNQFSVFVVGAGGFGVKRNSDKAKPPLPPPNRAPDAVVIDSTTRDQAALYRLSGDWNPLHIDPSFAAMGGFKKPILHGLCSFGFAGRHVLKQFADNDPSRFKAIKVRFAKPVTPGQSLQTEMWKEGNRIHIQCKVKETGEVVLTGAYVDLH 606          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDL---------SPANKV-----VNEVKAFGGIAYPNYDSVVDGENIIACA---IKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP-------VAGSRLTEDVFPPELFEALKPEY 770
            V V+TG+G GLGR +A E A+RGA +V+ D+    + +  ++         +P  K      V EV  F    +     V   EN+ + A    +E G++DILINNAG++     +   ++   R + V+ H  + TTK+    M   N G I+  +SS G++   G  +Y A+K G +G   +LS E     K  I    + P         G R+ +++ P      LKPE+
Sbjct:   39 VCVITGAGSGLGRLFAKEFARRGATLVLWDINSQSNEETAEMVRQIYKELDAPPLKAEAVGGVEEVPTFQPHVHTYVCDVGKRENVYSTAEQVRREVGEVDILINNAGVVSGHHLLECPDELIERTMVVNCHAHFWTTKAFLPKMLELNHGHIVTVASSLGLFSTAGVEDYCASKFGAIGFHESLSHEIQVSEKDGISMTLVCPYLVDTELFKGCRIRKEIEP--FLPPLKPEF 270          

Query:  156 VVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANK-----VVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            VVTG  GG+G+  A+E  ++GA + +    V RD D   L  A K      +N+ +    ++          EN+I  A ++ G +D+L+N AG      F  +  + +  ++ ++  G+   T++  T M+ +  GRI+F SS +G  G FG + YS +K  L GL  +L +E   YNI      P
Sbjct:   36 VVTGGSGGIGKCIAIECYRQGAFITL----VARDED--KLLRAKKEVEKFAINDKQVVLCVSVDVSSDYTQVENVIKQAQEKLGPVDMLVNCAGTAVAGKFEEMEVERFKELMELNYLGSVYPTRAVITTMKERRMGRIVFVSSQAGQIGLFGYTAYSPSKFALRGLAESLQMEMKPYNIYVTVAFP 216          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMR--NQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            + +VTG G G+GR     LA  GA VV+ D+      D    S  + +  +V     +     DSV   + +     + F    + +N AGI +D+  +++  + ++RVI V+L G++  T++    +     + G II   S  G  GN GQ+NY+A+K G+ GL  T + E +++ I+CN + P
Sbjct:   11 LTLVTGGGSGIGRAVCQRLASEGASVVVADIN-QESADETFSSLPDNLRGQVHMATVVDVSLKDSV--KKLVTNIQTRYFQPPSVCVNTAGITQDEFLLNMEEEQFDRVIQVNLKGSFLVTQAVAQALVACGASKGSIITVGSIVGKVGNLGQANYAASKAGVEGLTRTAAKELSRFGIRCNCVLP 193          

Query:  120 VMTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNE--VKAFGGIAY-PNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQS--NYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAP 701
            ++ ++  ++ VA VTG G G+GR +A  L + GAKV + DL         D + A  V  E  +K    I+   +     D + +I   + ++G I I  NNAGI  + +    + ++W++  +V+L G +   ++A   M  Q +G+II T+S + +     Q   +Y+ +K G+V L  TL  E     ++ N I+P
Sbjct:  298 ILDRMRLDEKVAYVTGGGQGIGRAFAHALGEAGAKVAVVDL---------DQARAEAVAQELFIKGISAISISADISKPADVQRMIDTIVSKWGAIHIACNNAGINLNSASEETTLEEWDQTFDVNLRGTFICCQAAGRVMLRQGYGKIINTASMASLIVPHPQKQLSYNTSKAGVVKLTQTLGTEWIDRGVRVNCISP 487          

Query:  123 MTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTENVPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLITEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIKPKL 1949
            MTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTE VPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTL+TEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIKPKL
Sbjct:    1 MTKLLFNDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLEGAKYNIKCNTIAPVAGSRLTEDVFPPELFEALKPEYVSPLVLYLCHPSSEESGSLFEVGAGWVGKVRWEVSRGVLLKTKQHNIVTVEDVRDHWDEITDFSQSRHPSSNKESMQNYVDMLQTELDENTNKTEKVPKSLEELIGKCRTTKLDKITFQNSILYAISVGINNSKIENLKFLYENHSNFSVLPTYAVIACFNNVFDLLNELSDHDVGIDLSQILHGEQYLEMHKPIRIDEKYSTTAEIVDVLDKIRGAVVLINATIHNTKKELISKLQFSLYIFGAGGFNGKKKSDKEFPSKALPDRKPDAIIEQYIDHNQAVLYRLNGDLNPLHVDPEFSKLFGFKKPILHGLCSFGIISQQAINIFADGNSDKFKKIKVRFSKPVIPGQTLLTEFWKDDKIVYVQCKIKETGTICLSGGYIEFNDANIKPKL 609          

Query:  141 NDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGG--IAYPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP 701
            N+ + ++TG+G GLG   A+  AK   ++++ D+         +     K   E + F    + Y     +   + ++  A K   E G +DILINNAG++  KS + +      R  NV++   + T ++    M +++ G I+  SS +G  G    S+Y A+K   +GL  +L  E     K NI+  T+ P
Sbjct:    5 NNKIVLITGAGHGLGAALAVRFAKHKCRLILWDI---------NFEGLQKTREECRQFQSESLIYIYKVDITKRKQVLDTADKIKSEIGFVDILINNAGVVSGKSILELDEASIERTFNVNVVSHFWTIQAFLPEMLSRDSGHIVSISSLAGFTGINKLSDYCASKFAAIGLHESLLCEINSKQKSNIQILTVCP 190          

Query:  141 NDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGG--IAYPNYDSVVDGENIIACAIK---EFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAP 701
            N+ + ++TG+G GLG   A+  AK   ++++ D+         +     K   E + F    + Y     +   + ++  A K   E G +DILINNAG++  KS + +      R  NV++   + T ++    M +++ G I+  SS +G  G    S+Y A+K   +GL  +L  E     K NI+  T+ P
Sbjct:   40 NNKIVLITGAGHGLGAALAVRFAKHKCRLILWDI---------NFEGLQKTREECRQFQSESLIYIYKVDITKRKQVLDTADKIKSEIGFVDILINNAGVVSGKSILELDEASIERTFNVNVVSHFWTIQAFLPEMLSRDSGHIVSISSLAGFTGINKLSDYCASKFAAIGLHESLLCEINSKQKSNIQILTVCP 225          

Query:  150 VAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGGIAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTL 653
            + ++TG+G GLG   A+  AK  +K+V+ D+  +     ++    ++    +  F  I   N   V      I     + G +DIL+NNAG++  KS + +  D  ++  NV++       ++    M  +N G+I+  +S +G++G    S+Y A+K   VGL  +L
Sbjct:   43 IILITGAGSGLGAALAISFAKLKSKLVLLDISEVGLKRTSNECEKHQSHTSIFIFQ-IDITNRMEVFKLSEKIK---NDIGIVDILVNNAGVVSGKSLLELDEDMVHKTFNVNVISHIWIIQAFLPDMLLRNSGQIVSLASLAGLFGVNKLSDYCASKFAAVGLQESL 206          

Query:  141 NDLVAVVTGSGGGLGRTYALELAKRGAKVVINDLGVLRDGDGNDLSPANKVVNEVKAFGG--------IAYPNYDSVVDGENIIACAIKEFGKIDILINNAGILRDKSFVHISNDDWNRVINVHLHGAYKTTKSAWTHMRNQNFGRIIFTSSSSGIYGNFGQSNYSAAKLGLVGLCNTLSLE---GAKYNIKCNTIAPV-AGSRLTEDV-FPPELFEALKPEYVS 776
            N+ V ++TG+G GLG   A++ AK+  ++V+ +          D+     +++E K +          +   N   +++  +++   +   G +DI+INNAG+    S   +  ++  + +NV+        +S    M ++N G ++  SS +G+ G    ++Y  +K  + G   +L  E     K  +   T+ P    +++ ++  F   + ++L+ EYV+
Sbjct:    5 NNKVVLITGAGNGLGAALAIKFAKQRCRLVLWE---------TDIDSLKIIIDECKKYQSDLFVLGIQVDISNRSQIINAADMVKTKV---GFVDIIINNAGVAFTSSITEMEENNIRKTLNVNGLSQIWIVQSFLQDMFSRNSGHVVSISSFTGLVGVRKLADYCFSKFAVAGFQESLLHEIYSAKKSGLHVLTVYPFHMKTKMFQNYKFDCPILKSLEVEYVA 217