Aquaporin
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021163 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Aquaporin vs. Ensembl Celegans
Match: aqp-9 (Aquaporin [Source:UniProtKB/TrEMBL;Acc:E5QCH4]) HSP 1 Score: 60.077 bits (144), Expect = 3.362e-10 Identity = 61/244 (25.00%), Postives = 97/244 (39.75%), Query Frame = 2 Query: 65 LPSVLYYTST-CFCSNILFQILYYNKKNSNL-KLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQCTC-LVIPVGLGCLVEFGAVFS----DGLIDSYYSYKPYTSSISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLA 775 + S+++Y S C + F ++ + L LL E I + + + G I N+G I ++ Y F PC V Y + L Q+ ++ AR + S+G H C+ L + + GC++E A F + +D Y + SI++ L S G+N++GMY NP+ A A T C HL VYW+SPL+A Sbjct: 5 VASLIFYGSVFAICELLRFLVIKSFDNSKRLSALLILEFIGTLQICVPMFDVGTILDNYGLLGVFVEITVIELANCY-FQRDAVAHPCPLVTNCYRKSKAIRRGIYVFLVQLAAAYLSYFVARLFWSIGVHPIHLELLDAESCSSDLTVAITTGCIIEGVATFVAKWFEKYVDERYDGETKLCSIANCL-------FSGLLCAIGINYTGMYANPIVAWACTFNCLGVSHAGHLFVYWLSPLIA 240
BLAST of Aquaporin vs. Ensembl Zebrafish
Match: aqp12 (aquaporin 12 [Source:ZFIN;Acc:ZDB-GENE-040718-310]) HSP 1 Score: 47.7506 bits (112), Expect = 7.196e-6 Identity = 58/219 (26.48%), Postives = 96/219 (43.84%), Query Frame = 2 Query: 161 LFYELISSFTLVACSMENGFIRK------NFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIA-NVYARSWCSLGWTYFHKVK-FANTQC-TCLVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSISSKLKFTFKWIVSLTWINYGVN-WSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVA 787 + EL+S+F L AC +E I + G + ++F+ V + + +G P ++++ + +LSI Q+IG +A V R W ++ + H +K ++C T L + LG E A L+ + S LK V+LT I Y N ++ Y+NP A A T C + + LVYW+ PL+ V +A Sbjct: 30 VLLELVSAFALCACRLEVDTIAEVGQWAGALGPDVAVTMLFLSIAVHTAVMQD-VSGNPAVTLLRLLQRDVSVVVAVLSIAAQLIGAFLALEVAGRFW-AMELSDMHMIKNLMMSECSTSLRVSTALGVSTEALAALLLLLLHLVLKNR------SQMLKVP-ALSVALTLIAYTANNYTSGYVNPALAYAVTFTCPGHSFLVYSLVYWLGPLIGVFLA 239
BLAST of Aquaporin vs. UniProt/SwissProt
Match: sp|G5CTG8|AQP11_MILTA (Aquaporin-11 OS=Milnesium tardigradum OX=46460 GN=AQP11 PE=2 SV=2) HSP 1 Score: 56.9954 bits (136), Expect = 4.568e-8 Identity = 57/225 (25.33%), Postives = 95/225 (42.22%), Query Frame = 2 Query: 140 KNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQCTC-LVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFKNSKP 811 K+S ++ E I + L A + E G I + +G ++ +F S +++ F T P K+ E +L F I+G ++ +A+ + S G H + N C L +PV +G E + L+ + Y S+IS V +T+ +G+ SG Y NP + A C S LVYW P+L +++ K +KP Sbjct: 37 KHSLARIAIEEFICAVQLCATNFELGVITQIYGFSAYALGLFFCSFTYTFTFQDGTC-DPSECYEKFCKREMSAREAVLRATFSIMGAAVSYRFAKIFWSFGLMATHMDFYKNESCDASLQVPVLIGLGFETFETIVNRLLQNMRHYNMLISAISD---------VCITF--FGLFVSGGYFNPTLSFAMEYGCQGLSGPSFFLVYWFGPILGSSIS--LKIAKP 247
BLAST of Aquaporin vs. TrEMBL
Match: A0A267FQJ3 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008191g3 PE=4 SV=1) HSP 1 Score: 107.457 bits (267), Expect = 6.537e-23 Identity = 77/252 (30.56%), Postives = 131/252 (51.98%), Query Frame = 2 Query: 62 LLPSVLYYTSTCFCSNILFQILYYNKKN-------SNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARS-WCSLGWTYFHKVKFANTQCTC-LVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSIS-SKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVA 787 LL S+LYY+ C+ +L + L + + ++ +L+++F + ACS+ENG IRK++G ++L + +L S G PC S ++ G++ S L+ + Q++ G +A YAR W LG + H++++ T C+ L +PVG G +E F+ GL D ++S + + + K ++S G++ +GMY+NP NA+AQT C+ S H+ VYW+ PL V A Sbjct: 25 LLVSLLYYS----CAMLLGRGLRHCVRRLITPTLGKSVASCLLDLVTTFQVCACSLENGVIRKHYGMPAYLCTLLLLGVWHSGTL-GDACGNPCGSWRQFVLGQARLSGTLIRMSLQMLAGAMAYRYARCCWWRLGLSSEHEMRYRITGCSSDLAVPVGAGFSIE---AFATGL-DLLVGLCVFSSGLRWERFQPLIKVLISTVLTYCGLHLTGMYVNPANATAQTFGCEGSQPWEHVTVYWLGPLAGVTGA 267
BLAST of Aquaporin vs. TrEMBL
Match: A0A267FFN2 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig031308g1 PE=4 SV=1) HSP 1 Score: 105.531 bits (262), Expect = 1.172e-22 Identity = 83/281 (29.54%), Postives = 137/281 (48.75%), Query Frame = 2 Query: 23 METKTEQNLALEYLLPSVLYYT-----STCFCSNILFQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQ--CTCLVIPVGLGCLVEFGAVFSDGLI----------DSYYSYKPYTSSISSKLKFTFKWIVSLTWINY-GVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFKNSKP 811 M T+ + +L + + S+LY+ S FCS I IL+ +K + L F +++F + ACS+EN + +G S+L V+F + P+ +G PC + ++ G + + + Q+ GG A +ARS+ S+G T H + A + + L +P G +EF VF+D ++ DS+ ++ S L TW+ Y G+ SGMY NP NASAQT+ C + + H+ VYW +PLLA ++ H ++ P Sbjct: 1 MSTEDQDSLTM---VVSLLYFAFTILLSRFFCSLIFSFILHRSKTVATCLLDF---VTTFQVCACSIENATFLRRYGMPSYLTVLFCQLYWNAISLPTGYSGNPCQNWRQFVAGRAKLAGTAGRMACQLAGGQAAFWFARSFWSVGLTATHGQRLAASASCVSDLTVPGAAGFGLEFLGVFADSMLVGGLAAFSSGDSWLRHEEVQRLTSCLLG---------TWLTYYGLPLSGMYANPANASAQTLGCRGTPLWLHIAVYWSAPLLATSLGHRLESRLP 266
BLAST of Aquaporin vs. TrEMBL
Match: A0A267H565 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig008191g1 PE=4 SV=1) HSP 1 Score: 106.686 bits (265), Expect = 1.497e-22 Identity = 77/252 (30.56%), Postives = 131/252 (51.98%), Query Frame = 2 Query: 62 LLPSVLYYTSTCFCSNILFQILYYNKKN-------SNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARS-WCSLGWTYFHKVKFANTQCTC-LVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSIS-SKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVA 787 LL S+LYY+ C+ +L + L + + ++ +L+++F + ACS+ENG IRK++G ++L + +L S G PC S ++ G++ S L+ + Q++ G +A YAR W LG + H++++ T C+ L +PVG G +E F+ GL D ++S + + + K ++S G++ +GMY+NP NA+AQT C+ S H+ VYW+ PL V A Sbjct: 25 LLVSLLYYS----CAMLLGRGLRHCVRRLITPTLGKSVASCLLDLVTTFQVCACSLENGVIRKHYGMPAYLCTLLLLGVWHSGTL-GDACGNPCGSWRQFVLGKARLSGTLIRMSLQMLAGAMAYRYARCCWWRLGLSSEHEMRYRITGCSSDLAVPVGAGFSIE---AFATGL-DLLVGLCVFSSGLRWERFQPLIKVLISTLLTYCGLHLTGMYVNPANATAQTFGCEGSQPWEHVTVYWLGPLAGVTGA 267
BLAST of Aquaporin vs. TrEMBL
Match: A0A267GFX5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig029046g1 PE=4 SV=1) HSP 1 Score: 100.523 bits (249), Expect = 9.124e-21 Identity = 78/269 (29.00%), Postives = 139/269 (51.67%), Query Frame = 2 Query: 23 METKTEQNLALEYLLPSVLYYT-----STCFCSNILFQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQ--CTCLVIPVGLGCLVEFGAVFSDG-LIDSYYSYKPYTSSI-SSKLKFTFKWIVSLTWINY-GVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFK 799 M T+ + +L + + S+LY+ S FCS I IL+ ++ + + +++F + ACS+EN + +G S+L V+F S P+ +G PC + ++ G + + + Q+ GG A +ARS+ S+G T H + A + + L +P G +EF VF+D L+ ++ S + + +++ +++S TW+ Y G+ +GM+ NP NASAQT+ C + + H VYW +PLLAV++ H + Sbjct: 1 MSTEDQDSLTM---VVSLLYFAFTILLSRFFCSLIFSFILH---RSQTVATCLLDFVTTFQVCACSIENATFLRCYGMPSYLTVLFCQLYWNSISLPTGYSGNPCQNWRQFVAGRAKLAGTAGRMACQLAGGQAAFWFARSFWSVGLTATHGQRLAASASCVSDLTVPGAAGFGLEFLGVFADSMLVGGLAAFSSGDSWLRNEEVQRPLLYVLS-TWLTYHGLYLTGMFSNPANASAQTLGCRGTPLWLHFAVYWAAPLLAVSLGHRLE 262
BLAST of Aquaporin vs. TrEMBL
Match: A0A267GED8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig032230g1 PE=4 SV=1) HSP 1 Score: 99.3673 bits (246), Expect = 2.228e-20 Identity = 76/270 (28.15%), Postives = 137/270 (50.74%), Query Frame = 2 Query: 23 METKTEQNLALEYLLPSVLYYTSTCFCSNIL----FQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQC--TCLVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSIS----SKLKFTFKWIVSLTWINY-GVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFK 799 M T+ + +L + + S+LY+ T S L F + + K LL + +++F + ACS+EN + +G ++L V+F + P+ +G PC + ++ G + + + Q+ GG A +ARS+ S+G T H + A + + L +P G +EF VF+D ++ + ++S S +++ +++S TW+ Y G+ +GMY NP NASAQT+ C + + H VYW +PL+AV++ H + Sbjct: 1 MSTEDQDSLTM---VVSLLYFAFTILLSRFLCSLIFSFILHRSKTVATCLL--DFVTTFQVSACSIENATFLRRYGMPTYLTVLFCQLYWNAISLPTGYSGNPCQNWRQFVAGRAKLAGTAGRMACQLAGGQAAFWFARSFWSVGLTATHGQRLAASASCISDLTVPGAAGFGLEFLGVFADSMLVA--GLAAFSSGDSWLRHEEVQRPLLYMLS-TWLTYHGLYLTGMYSNPANASAQTLGCRGTPLWLHFAVYWAAPLVAVSLGHRLE 262
BLAST of Aquaporin vs. Ensembl Nematostella
Match: EDO35733 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKN0]) HSP 1 Score: 47.7506 bits (112), Expect = 2.347e-6 Identity = 59/237 (24.89%), Postives = 95/237 (40.08%), Query Frame = 2 Query: 170 ELISSFTLVACSMENGFIRKNFGDFSFLFVIFILS--QVFSYIFPSPTAGTPCNSVIKYYNGESCKS------HCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQCTCLVIPVGLGCLVEFGAVFSDGLID-----SYYSYKPYTSSISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIW--CDNSYIISHLLVYWVSPLLAVAVA-------HGFKNSKPK 814 ELISSF AC E I + + + + FIL + YIF +A PC G CK + +L++LFQ G ++ R + H + + T L +P+ +G +E F ++D + P S + +++ + G +G++MNPV A+ T ++ HL V+WV P+L VA H + KPK Sbjct: 38 ELISSFQFSACIFELVVIGRFYSPYVGIACSFILLFLKNSEYIFDG-SAANPCG----LLEGVVCKLKKPWFLNFVLTVLFQFSGALLSFPVMRFMWQKTNSEMHFKQLNSELGTTLQVPIIIGFAIEVFTTFVVTMVDFVTRGEMRRFNPILRSTTC---------IAVCYALTGT--TGVWMNPVFATVHTFLFTTGKELLLEHLFVFWVGPILGTLVAIGIDFKTHKHEVQKPK 258
BLAST of Aquaporin vs. Planmine SMEST
Match: SMESG000005963.1 (SMESG000005963.1) HSP 1 Score: 533.487 bits (1373), Expect = 0.000e+0 Identity = 263/266 (98.87%), Postives = 264/266 (99.25%), Query Frame = 2 Query: 23 METKTEQNLALEYLLPSVLYYTSTCFCSNILFQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIANVYARSWCSLGWTYFHKVKFANTQCTCLVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSSISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFKNSKPKSD 820 METKTEQNLALEYLLPSVLYYTSTCFCSNILFQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIA+VYARSWCSLGWTYFHKVKFANTQCT LVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTS ISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFKNSKPKSD Sbjct: 1 METKTEQNLALEYLLPSVLYYTSTCFCSNILFQILYYNKKNSNLKLLFYELISSFTLVACSMENGFIRKNFGDFSFLFVIFILSQVFSYIFPSPTAGTPCNSVIKYYNGESCKSHCLLSILFQIIGGCIAHVYARSWCSLGWTYFHKVKFANTQCTSLVIPVGLGCLVEFGAVFSDGLIDSYYSYKPYTSLISSKLKFTFKWIVSLTWINYGVNWSGMYMNPVNASAQTIWCDNSYIISHLLVYWVSPLLAVAVAHGFKNSKPKSD 266 The following BLAST results are available for this feature:
BLAST of Aquaporin vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Aquaporin vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Aquaporin vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Aquaporin vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Aquaporin vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Aquaporin vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Aquaporin vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 1
BLAST of Aquaporin vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Aquaporin vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Aquaporin vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Aquaporin vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Aquaporin vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Aquaporin vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Aquaporin vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021163 ID=SMED30021163|Name=Aquaporin|organism=Schmidtea mediterranea sexual|type=transcript|length=1000bpback to top protein sequence of SMED30021163-orf-1 >SMED30021163-orf-1 ID=SMED30021163-orf-1|Name=SMED30021163-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=267bp METKTEQNLALEYLLPSVLYYTSTCFCSNILFQILYYNKKNSNLKLLFYEback to top Annotated Terms
The following terms have been associated with this transcript:
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