MARVEL domain-containing protein

Overview
NameMARVEL domain-containing protein
Smed IDSMED30021161
Length (bp)861
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of MARVEL domain-containing protein (SMED30021161) t-SNE clustered cells

Violin plots show distribution of expression levels for MARVEL domain-containing protein (SMED30021161) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of MARVEL domain-containing protein (SMED30021161) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for MARVEL domain-containing protein (SMED30021161) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30021161

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30021161h1SMcG0021364 Contig22GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30021161h1SMcG0021364 Contig22GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30021161h1SMcG0021364 Contig22GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Smed sexual biotypeSMED30021161h1SMcG0021364 Contig52169uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30021161h1SMcG0021364 Contig52169newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30021161h1SMcG0021364 dd_Smed_v4_1798_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30021161h1SMcG0021364 dd_Smed_v4_1798_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30021161h1SMcG0021364 dd_Smed_v4_1798_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Match: SYNPR (synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507])

HSP 1 Score: 124.79 bits (312), Expect = 2.286e-33
Identity = 76/208 (36.54%), Postives = 115/208 (55.29%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V KEP  F++ LE++ AI AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  I   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:   14 RVLKEPLAFLRALELLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Match: SYP (synaptophysin [Source:HGNC Symbol;Acc:HGNC:11506])

HSP 1 Score: 117.087 bits (292), Expect = 3.302e-30
Identity = 76/227 (33.48%), Postives = 114/227 (50.22%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEPILP 739
             V KEP GF+K L+ + AI AFAT   +S  +Q +  C     + + I     YPF +    F    C        L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + VC Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T    P LR       +   P
Sbjct:   20 RVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAP 246
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Match: SYP (synaptophysin [Source:HGNC Symbol;Acc:HGNC:11506])

HSP 1 Score: 117.087 bits (292), Expect = 3.302e-30
Identity = 76/227 (33.48%), Postives = 114/227 (50.22%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEPILP 739
             V KEP GF+K L+ + AI AFAT   +S  +Q +  C     + + I     YPF +    F    C        L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + VC Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T    P LR       +   P
Sbjct:   20 RVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAP 246
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Match: SYNPR (synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507])

HSP 1 Score: 110.153 bits (274), Expect = 6.677e-28
Identity = 69/195 (35.38%), Postives = 106/195 (54.36%), Query Frame = 2 
Query:  125 EIIMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             ++ AI AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  I   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:   18 HLLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 212
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Match: SYNPR (synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507])

HSP 1 Score: 109.768 bits (273), Expect = 7.572e-28
Identity = 69/193 (35.75%), Postives = 105/193 (54.40%), Query Frame = 2 
Query:  131 IMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + AI AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  I   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:    9 LFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 201
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Celegans
Match: sph-1 (SynaptoPHysin [Source:UniProtKB/TrEMBL;Acc:O44511])

HSP 1 Score: 47.3654 bits (111), Expect = 3.272e-6
Identity = 55/211 (26.07%), Postives = 101/211 (47.87%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC-----NMTIMNSIPINYPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQ--HLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRD 688
            ++++ FK P GFI+ ++ +  I+A A ++  S  ++ NY C     N+T  NS    Y F++   K +    N+T    S D +    + FF FV V  L+Y IF C  Y+ +     +  ++ L +   + +L   +   SS+W      I   TS E + +       +  N+  + ++   G L+ S++A + C L +A N WF+ ++
Sbjct:    8 LNISAFKFPLGFIRIIQFVFIIIAIAAIN--SWGLELNYHCVDGTGNIT-RNSTQKVYTFSLSKVK-LTGCDNQTRTFWSGDDSASGSAGFFYFVNVTALIYVIFICFVYVIFWNIYQTEKRIPLVDLGATALLFILFFFCSSIWWAGANTIGNATSDERLTELFGQGSWKGQNAQFLSRDVNNGKLAISVLANWVCVLCFAFNCWFIWKE 214
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Match: sypl2a (synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1434])

HSP 1 Score: 119.013 bits (297), Expect = 6.753e-32
Identity = 70/208 (33.65%), Postives = 114/208 (54.81%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN--YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTP 694
            +D+   KEP GFI+ LE +  I AFAT  G+  +  F  +C       +  N  YPF + S+ ++I+ CN ++ TT L G++ S ++FFV +GV   LY  F+ I YL Y +    +N+  + + V++ +  F WLV SS W   + ++KY T    +   + +C   + C +      G L+AS++ GF   +LWA N WF+ ++TP
Sbjct:   13 LDLGPVKEPLGFIRLLEWVFTICAFATTGGYVGSTVFTLKCPDKDDVDVTANFGYPFRLPSHPYLINHCNGSKNTTYLQGDFSSSAEFFVSIGVLGFLYCTFTLILYLGYQQVYRESNRGPIIDLVVTGIFAFLWLVCSSAWGKGLTDVKYATDPSRL---IILCLPEDKCEIKSYPSVGRLNASVLFGFLNLILWAGNCWFIYKETP 217
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Match: sypl2a (synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1434])

HSP 1 Score: 119.013 bits (297), Expect = 6.753e-32
Identity = 70/208 (33.65%), Postives = 114/208 (54.81%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN--YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTP 694
            +D+   KEP GFI+ LE +  I AFAT  G+  +  F  +C       +  N  YPF + S+ ++I+ CN ++ TT L G++ S ++FFV +GV   LY  F+ I YL Y +    +N+  + + V++ +  F WLV SS W   + ++KY T    +   + +C   + C +      G L+AS++ GF   +LWA N WF+ ++TP
Sbjct:   13 LDLGPVKEPLGFIRLLEWVFTICAFATTGGYVGSTVFTLKCPDKDDVDVTANFGYPFRLPSHPYLINHCNGSKNTTYLQGDFSSSAEFFVSIGVLGFLYCTFTLILYLGYQQVYRESNRGPIIDLVVTGIFAFLWLVCSSAWGKGLTDVKYATDPSRL---IILCLPEDKCEIKSYPSVGRLNASVLFGFLNLILWAGNCWFIYKETP 217
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Match: SYNPR (si:dkey-30j16.3 [Source:ZFIN;Acc:ZDB-GENE-141212-294])

HSP 1 Score: 119.013 bits (297), Expect = 2.597e-31
Identity = 74/208 (35.58%), Postives = 121/208 (58.17%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC-NMTIMN-SIPIN--YPFAIDSYKFVISLC-NETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQV-TNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V K P GFI+ LE + AI AFAT  G+S  ++ +  C N +  N SI IN  YPF ++  +F + +C    ++   L G++ S ++FFV + VF+ LYS+ + + Y+F+      NN+  L +F+++ V +F WLV SS WA  + ++K  T  + +   +  C+V TN C  +    +  L+ S+V G+  F+LWA NIWF+ ++T
Sbjct:   14 QVLKLPLGFIRLLEWLFAIFAFATCGGYSGQMRVSVDCINKSDSNLSIAINFAYPFRLNQVEFDVPMCEGRRQERLYLIGDFSSSAEFFVTIAVFSFLYSLLATVVYIFFQNKYRENNRGPLIDFIVTVVFSFMWLVSSSAWAKGLSDVKAATDPDEVVLLVSACKVQTNKCSSLYGPRWSGLNTSVVFGYLNFVLWAGNIWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Match: sypa (synaptophysin a [Source:ZFIN;Acc:ZDB-GENE-031104-2])

HSP 1 Score: 117.087 bits (292), Expect = 1.312e-30
Identity = 76/224 (33.93%), Postives = 119/224 (53.12%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLC-NETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVT-NSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEP 730
            V K P GFIK LE + AI AF+T   +S + + + +C     +++ I+    YPF +    F    C N       L G+Y S ++FFV + VF  LYS+ +   Y+F  E    NNK  L +F ++CV TF WLV S+ WA  + ++K  T  E +   +  C+ + N CR + + V   L+ S+V GF   +LW  N+WF+ ++T    P +R + + E +P
Sbjct:   15 VLKVPLGFIKILEWVFAIFAFSTCGSYSGSFRMSVECKNRSDSNLKIDVDFEYPFRLHQVYFNAPTCKNGQSDRFFLVGDYSSSAEFFVTIAVFAFLYSMAALSIYIFAFEKYRENNKGPLIDFGVTCVFTFMWLVSSAAWAKGLSDVKTATDPEKVLDLIPACENSGNRCREVYDPVMSGLNTSVVFGFLNLILWTGNLWFVFKETGIVAPFMRQQPAQEKQP 238
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Match: sypa (synaptophysin a [Source:ZFIN;Acc:ZDB-GENE-031104-2])

HSP 1 Score: 117.087 bits (292), Expect = 1.312e-30
Identity = 76/224 (33.93%), Postives = 119/224 (53.12%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLC-NETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVT-NSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEP 730
            V K P GFIK LE + AI AF+T   +S + + + +C     +++ I+    YPF +    F    C N       L G+Y S ++FFV + VF  LYS+ +   Y+F  E    NNK  L +F ++CV TF WLV S+ WA  + ++K  T  E +   +  C+ + N CR + + V   L+ S+V GF   +LW  N+WF+ ++T    P +R + + E +P
Sbjct:   15 VLKVPLGFIKILEWVFAIFAFSTCGSYSGSFRMSVECKNRSDSNLKIDVDFEYPFRLHQVYFNAPTCKNGQSDRFFLVGDYSSSAEFFVTIAVFAFLYSMAALSIYIFAFEKYRENNKGPLIDFGVTCVFTFMWLVSSAAWAKGLSDVKTATDPEKVLDLIPACENSGNRCREVYDPVMSGLNTSVVFGFLNLILWTGNLWFVFKETGIVAPFMRQQPAQEKQP 238
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Xenopus
Match: agl (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase [Source:Xenbase;Acc:XB-GENE-1001429])

HSP 1 Score: 101.293 bits (251), Expect = 7.831e-25
Identity = 59/209 (28.23%), Postives = 108/209 (51.67%), Query Frame = 2 
Query:   92 FKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMN-------SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNS-CRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             +EP GFIK LE + AI AF     +S        C     +       S+P  YPF +   ++ +  C + E+    L G++ + ++FFV +GVF  LYS+F+ + YL +HE      ++ + +  ++    F WLV +S W   + ++K  T   ++   + +CQ+  + C    +  + + + S++ GF  FL+WA+N+WF+ ++T
Sbjct:   33 LEEPLGFIKLLEWLFAIFAFGCCGSYSGETAATVMCKTETDSDTEIKLISVPFAYPFRLYRQRYEMPACEDIERRILHLTGDFSAPAEFFVTMGVFAFLYSMFALVVYLRFHEEYTKIRRVPIVDLCVTGAFAFLWLVAASAWGKGLMDVKVATQPSNLVSSMPLCQMEKATCNAGSQPYFALANISVLFGFLNFLIWAANVWFVFKET 241
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Xenopus
Match: sypl1 (synaptophysin-like 1 [Source:NCBI gene;Acc:394679])

HSP 1 Score: 98.9821 bits (245), Expect = 3.804e-24
Identity = 72/211 (34.12%), Postives = 108/211 (51.18%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN---YPFAIDSYKF--VISL-CNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            +++   KEP GFIK LE   +I +FAT  G+S   +    C  +  N        YPF ++   F  +  L CN+T K   L G++ + +QF+V +GVF  LY + + +FYL + +    + K  L +F I+      WLV SS WA  + +IK  TS + I Q+   C     C   QE   G L+ S+  GF   +LWA N WF+ ++T
Sbjct:    6 LNLGPLKEPLGFIKLLEWFASIFSFATCGGYSGKTELIVSCLGSSENKTATASFMYPFRLNVQVFEGIPKLFCNQTWKDFHLTGDFSAPAQFYVSIGVFAFLYCMAALVFYLGFMQLYRDSQKFPLCDFFITVFFALMWLVSSSAWAKGLTDIKASTSPQGIAQY--TCPTGYKCLPGQESHMGSLNISVAFGFLNLILWAGNAWFVYKET 214
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Xenopus
Match: syp (synaptophysin [Source:NCBI gene;Acc:100144928])

HSP 1 Score: 98.9821 bits (245), Expect = 1.076e-23
Identity = 69/232 (29.74%), Postives = 115/232 (49.57%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC---NMTIMN-SIPINYPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQ-HLKVCQVTN---SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEPILPQS 745
             V KEP GFIK L+ + +I AFAT  G+S     +  C   N +  N  +   YPF +    F    C    +   L G+Y S ++FFV + VF+ LYS+ +   Y+F       NNK  + + + + + TF WLV SS WA  + +IK  T  E + +  +  C+ +    +C  +++ V   L+ S+  GF   +LW  N+WF+ ++T    P +++    + +   P +
Sbjct:   14 RVVKEPLGFIKVLQWLFSIFAFATCGGYSGQFSLSIDCKNKNESKPNIKVDFEYPFRLHQEYFDAPTCRGATRKVFLVGDYSSSAEFFVTIAVFSFLYSLAALAVYIFLQNKYRENNKGPMIDCIATAIFTFMWLVSSSAWAKGLSDIKLATDPELVIETQIPECRKSEYDMTCSELRDPVMSGLNTSVAFGFLNCILWLGNVWFVFKETGWTAPFIKYPPPAQEKQPAPDA 245
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Xenopus
Match: SYNPR (synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507])

HSP 1 Score: 73.9442 bits (180), Expect = 1.003e-14
Identity = 57/193 (29.53%), Postives = 95/193 (49.22%), Query Frame = 2 
Query:  131 IMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLK-VCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + AI AFAT  G+S  ++ +  C     + + I+    YPF +    F    C    +   SL G++ S ++FFV + VF  LYS+ + + Y+FY      NN+  L  ++++   +   LV +S W G +  +        I  ++  V +V NSC   +  V    + + V GF  F+LWA NIWF+ ++T
Sbjct:    8 LFAIFAFATCGGYSGELRVSVDCPNKTQSDLSIDIAIAYPFRLYQVNFDAPTCEGKRREKLSLIGDFSSSAEFFVTIAVFAFLYSLAATVVYIFYQNKYRENNRGPLITYIVTVNHSIINLVLASSWEGGLCNVSRLVDPHDILMYVSSVKKVGNSCLRRRGEVQPSYTTNSVFGFLNFILWAGNIWFVFKET 200
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Match: Synpr (synaptoporin [Source:MGI Symbol;Acc:MGI:1919253])

HSP 1 Score: 122.479 bits (306), Expect = 9.369e-33
Identity = 76/219 (34.70%), Postives = 119/219 (54.34%), Query Frame = 2 
Query:   62 PISK*MDVNVF---KEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            P+S+      F   KEP  F++ LE++ A+ AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  +   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:    3 PVSQVASAGTFRALKEPLAFLRALELLFAMFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLQQVTFEVPTCEGKEQQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Match: Syp (synaptophysin [Source:MGI Symbol;Acc:MGI:98467])

HSP 1 Score: 110.538 bits (275), Expect = 6.337e-28
Identity = 70/208 (33.65%), Postives = 113/208 (54.33%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTS-LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V KEP GF+K L+ + AI AFAT   ++  ++ + +C     +++ I     YPF +    F    C +   T   L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + +C Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T
Sbjct:   20 RVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKET 227
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Match: Synpr (synaptoporin [Source:MGI Symbol;Acc:MGI:1919253])

HSP 1 Score: 107.842 bits (268), Expect = 2.558e-27
Identity = 67/193 (34.72%), Postives = 105/193 (54.40%), Query Frame = 2 
Query:  131 IMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + A+ AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  +   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:    9 LFAMFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLQQVTFEVPTCEGKEQQKLALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 201
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Match: Sypl (synaptophysin-like protein [Source:MGI Symbol;Acc:MGI:108081])

HSP 1 Score: 103.219 bits (256), Expect = 7.793e-26
Identity = 71/216 (32.87%), Postives = 110/216 (50.93%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMN-----SIPINYPFAIDSYKFV----ISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTN--SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            +++N  KEP GFIK LE   +I AFAT  GF    +    C    +N     +    YPF ++   F     +S+C+   +   L G+Y S +QF+V   VF  LY I + + Y+ Y      + KL + +F+++ V TF WLV SS WA  + +IK  T    I + L++C   +  SC  +     G L+ S++ GF   +LW  N WF+ ++T
Sbjct:    6 INLNPLKEPLGFIKILEWFASIFAFATCGGFKGKTEIQVNCPKVGVNKNQTVTATFGYPFRLNQASFHTPPNVSVCDVNWEKHVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHR-IVEELEICNPESGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKET 220
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Match: Sypl (synaptophysin-like protein [Source:MGI Symbol;Acc:MGI:108081])

HSP 1 Score: 103.219 bits (256), Expect = 1.158e-25
Identity = 71/216 (32.87%), Postives = 110/216 (50.93%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMN-----SIPINYPFAIDSYKFV----ISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTN--SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            +++N  KEP GFIK LE   +I AFAT  GF    +    C    +N     +    YPF ++   F     +S+C+   +   L G+Y S +QF+V   VF  LY I + + Y+ Y      + KL + +F+++ V TF WLV SS WA  + +IK  T    I + L++C   +  SC  +     G L+ S++ GF   +LW  N WF+ ++T
Sbjct:   24 INLNPLKEPLGFIKILEWFASIFAFATCGGFKGKTEIQVNCPKVGVNKNQTVTATFGYPFRLNQASFHTPPNVSVCDVNWEKHVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTNLYRDSRKLPMIDFIVTLVATFLWLVSSSAWAKALTDIKVATGHR-IVEELEICNPESGVSCYFVSVTSMGSLNVSVIFGFLNMILWGGNAWFVYKET 238
[Close]
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Match: sp|P20488|SYPH_BOVIN (Synaptophysin OS=Bos taurus OX=9913 GN=SYP PE=1 SV=3)

HSP 1 Score: 120.168 bits (300), Expect = 1.005e-30
Identity = 77/214 (35.98%), Postives = 113/214 (52.80%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLR 703
            V KEP GF+K L+ + AI AFAT   +S  +Q +  C     + + I     YPF +    F    C    K   L GNY S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + VC Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T    P LR
Sbjct:   21 VVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTKSDLNIEVEFEYPFRLHEVYFEAPTCQGDPKKIFLVGNYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKGMHVCHQPGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLR 234
[Close]
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Match: sp|P08247|SYPH_HUMAN (Synaptophysin OS=Homo sapiens OX=9606 GN=SYP PE=1 SV=3)

HSP 1 Score: 117.087 bits (292), Expect = 1.586e-29
Identity = 76/227 (33.48%), Postives = 114/227 (50.22%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEPILP 739
             V KEP GF+K L+ + AI AFAT   +S  +Q +  C     + + I     YPF +    F    C        L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + VC Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T    P LR       +   P
Sbjct:   20 RVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAP 246
[Close]
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5YJC1|SYPH_SPECI (Synaptophysin OS=Spermophilus citellus OX=9997 GN=SYP PE=2 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 1.265e-28
Identity = 74/226 (32.74%), Postives = 115/226 (50.88%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEPILP 739
            V KEP GF+K L+ + AI AFAT   ++  ++ + +C     + + I     YPF +    F    C        L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + VC Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T    P LR       +   P
Sbjct:   15 VIKEPLGFVKVLQWVFAIFAFATCGSYNGELRLSVECANKTESDLSIEVEFEYPFRLHQVYFDAPNCRGGTTKVFLLGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMDVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAP 240
[Close]
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8TBG9|SYNPR_HUMAN (Synaptoporin OS=Homo sapiens OX=9606 GN=SYNPR PE=1 SV=1)

HSP 1 Score: 109.768 bits (273), Expect = 3.636e-27
Identity = 69/193 (35.75%), Postives = 105/193 (54.40%), Query Frame = 2 
Query:  131 IMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + AI AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +F+++ V +F WLVGSS WA  + ++K  T  + +   +  C Q +N C  I   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:    9 LFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 201
[Close]
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Match: sp|P07825|SYPH_RAT (Synaptophysin OS=Rattus norvegicus OX=10116 GN=Syp PE=1 SV=1)

HSP 1 Score: 110.538 bits (275), Expect = 4.197e-27
Identity = 70/208 (33.65%), Postives = 113/208 (54.33%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTS-LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V KEP GF+K L+ + AI AFAT   ++  ++ + +C     +++ I     YPF +    F    C +   T   L G+Y S ++FFV V VF  LYS+ +   Y+F       NNK  + +F+ + V  F WLV SS WA  + ++K  T  E+I + + +C Q  N+C+ +++ V   L+ S+V GF   +LW  N+WF+ ++T
Sbjct:   14 RVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. TrEMBL
Match: A0A2P6L229 (Synaptophysin OS=Nephila clavipes OX=2585209 GN=NCL1_19826 PE=4 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 3.221e-38
Identity = 79/215 (36.74%), Postives = 128/215 (59.53%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPINYPFAIDSYKFVISLCNETEKTTS-------LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC---QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + + V KEP+GFI+ ++ IMAILAF+T +GFS   +F+  C     + IP+ Y F    Y F  +  N  E           L  ++ + ++FFV  GV + LY+I   I Y+F+H++  +N KL + +  IS +L+ FW+ GSS WA  V ++KYY   E +F+ L +C   + ++ C  I++G YG+L+ S++ GF  FLLW S++WF+ ++T
Sbjct:   33 LSIQVIKEPRGFIRIIQCIMAILAFSTTAGFSTECEFSVSCGEGKDDDIPVEYEFG---YPFSHTELNVPENCDEKNILHLILPFDFSNAAEFFVATGVMSFLYTILILIVYIFFHQSYGNNPKLPVVDLGISAILSIFWMAGSSAWAQGVADLKYYLHPETVFKFLPICLSEKNSHECDTIEDGSYGVLNGSLILGFANFLLWTSSLWFIYKET 244
[Close]
BLAST of MARVEL domain-containing protein vs. TrEMBL
Match: A0A2L2XX87 (Synaptophysin-like protein 2 (Fragment) OS=Parasteatoda tepidariorum OX=114398 PE=2 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 1.445e-31
Identity = 74/212 (34.91%), Postives = 120/212 (56.60%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPINYPFAIDSYK---FVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC---QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            + V V KEP+GFI+ ++ IMAILAF+T +GFS + +F+  C    +  + +NY F     K    V   C   E+    L  +Y + ++F+V  GV   LY++   + Y+F+H++   N+KL   +   + + T FW+ GSS WA  V ++KYY     + Q+L +C      N+C    +G YG L+AS++ GF  FLLW  ++WF+ ++T
Sbjct:    6 LSVRVMKEPRGFIRVIQCIMAILAFSTTAGFSTSCEFSISCGDGKI--VDVNYTFGYPFEKSELLVPDTCASNERLPLKLPFDYSTIAEFYVTTGVLAFLYTLGILVVYIFFHQSYSENSKLPALDLCATAIFTIFWMAGSSAWAQGVVDLKYYMDPATVIQYLFICIRNHSENNCMTEDDGSYGTLNASLILGFANFLLWLVSLWFIYKET 215
[Close]
BLAST of MARVEL domain-containing protein vs. TrEMBL
Match: I3M739 (Synaptoporin OS=Ictidomys tridecemlineatus OX=43179 GN=SYNPR PE=4 SV=1)

HSP 1 Score: 127.872 bits (320), Expect = 1.779e-31
Identity = 79/219 (36.07%), Postives = 120/219 (54.79%), Query Frame = 2 
Query:   62 PISK*MDVNVF---KEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC-NMTIMN---SIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            P+S+      F   KEP  F++ LE++ AI AFAT  G+S  ++ +  C N T  N    I   YPF +    F +  C   E+   +L G+  S ++FFV V VF  LYS+ + + Y+F+      NN+  L +FV++ V +F WLVGSS WA  + ++K  T  + + Q +  C Q +N C  +   V   L+ S+V GF  F+LWA NIWF+ ++T
Sbjct:    3 PVSQLASAGTFRALKEPLAFLRALELLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFVVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLQLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. TrEMBL
Match: D1LXF4 (Synaptoporin-like protein OS=Saccoglossus kowalevskii OX=10224 PE=2 SV=1)

HSP 1 Score: 127.102 bits (318), Expect = 2.213e-31
Identity = 73/237 (30.80%), Postives = 119/237 (50.21%), Query Frame = 2 
Query:   65 ISK*MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPINYPFAIDSYKFVIS--LCNETEKTTSLDGNYXXXXXXXXXXXX-------XTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTN-SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILPQS 745
            I+K   + V KEP+GFIKFLE I+AI AFAT +G      F   CN     +  ++Y +  D  +  IS  LC  T  ++++  N ++                    LY I + ++Y+F+ +N    + L L +FV++C+    WL GSS WA  V ++KY T  + +   L  C + + +C +++   Y  L+ SIV GF    +WA N+WF+ ++TP      + +  P  P +
Sbjct:    8 ITKNYSLRVLKEPRGFIKFLEFILAIFAFATTAGHCGYFTFKLSCNDDDYPAERVDYCYPFDMTQTTISYPLCVHTTPSSTMAPNEINLKLDPSSSAEYFVAVGVLAFLYCIVALVWYVFFEKNHRDKDLLPLGDFVMTCIFVLLWLTGSSAWAKGVTDVKYATDFDTVQSLLPECSLESVTCTLVKSPSYATLNVSIVFGFLNMFVWAGNVWFVYKETPWFDKYEASKQRPANPMT 244
[Close]
BLAST of MARVEL domain-containing protein vs. TrEMBL
Match: K1RPP1 (Synaptophysin OS=Crassostrea gigas OX=29159 GN=CGI_10015678 PE=4 SV=1)

HSP 1 Score: 132.494 bits (332), Expect = 7.193e-31
Identity = 81/214 (37.85%), Postives = 122/214 (57.01%), Query Frame = 2 
Query:   92 FKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQ-CNMTIMNSIPINYPFAIDSYKFVISLCNETE-----KTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYT--SREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHR 709
             KEPKGFIK ++ I+AI AFAT +     +    + C+  IM  + I YPF I +  F   LCN T      K   L+G+  S ++F+VF GV   LY I + + YLF+ E    +N   + +FVIS V+T  WLV SS WA  +  +KYYT  ++  +F+ +  C  T++C   +   +G L+AS++ GF   L+W  N+WFL ++TP  ++R
Sbjct:  989 LKEPKGFIKVIQWILAIFAFATTTSVDTFLTVTARGCSDAIMEKVDIAYPFDIQNSYFTTPLCNRTSNPDGTKVYLLEGS-RSSAEFYVFFGVMVFLYCIAALVVYLFFEELYRRSNVWSIVDFVISAVITLLWLVSSSAWAQGLVNLKYYTDLNKCGLFKTITTCS-TDNCVQTEFPNFGSLNASVIFGFLNMLVWGGNLWFLYKETPWFQNR 1200
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Match: sypl2b (synaptophysin-like protein 2 [Source:NCBI gene;Acc:103021443])

HSP 1 Score: 119.013 bits (297), Expect = 4.884e-32
Identity = 78/212 (36.79%), Postives = 117/212 (55.19%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC---NMTIMNSIPINYPFAIDSYKFVISLC--NETEKTTS-LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            +D++  KEP GFI+ LE + AI AFA+ SG+S T  FN QC   N     +I   YPF ++  K+ +  C  N++E +TS L GN  S ++FFV VGV   LY   + + YL Y      +N+  L + +I+ + TF WLV SS W   + ++K  T    +     VC +  N C       YG L++S+++GF   +LWA N WF+ ++T
Sbjct:    6 LDLSPLKEPLGFIRVLEWVFAIFAFASTSGYSGTTSFNIQCQGLNPPHQINITFQYPFRLNEVKYDVPACKVNKSESSTSYLTGNQSSSAEFFVAVGVLAFLYCSATLVLYLGYQNLYRESNRGPLIDLLITGLFTFLWLVSSSAWGKGLNDVKNVTHPNTLVSITSVCREPKNVCTAGGVPSYGHLNSSVISGFLNLILWAGNCWFVFKET 217
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Match: si:dkey-30j16.3 (synaptoporin [Source:NCBI gene;Acc:103035011])

HSP 1 Score: 114.39 bits (285), Expect = 8.615e-30
Identity = 69/208 (33.17%), Postives = 115/208 (55.29%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLC-NETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQV-TNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V K P GFI+ LE + AI AFAT  G+S  ++    C     +++ IN    YPF ++     +  C   +++   L G++ S ++FFV + VF  LYS+ + + Y+F+      NN+    +F+++ V +F WLV SS WA  + ++K  T  E +   +  C+V TN C  +   ++  L+ S+V G+  F+LWA NIWF+ ++T
Sbjct:   14 QVLKVPLGFIRVLEWLFAIFAFATCGGYSGQLRVRVDCENKPDSNLSINIDFAYPFRLNQVYVDVPTCKGRSQERLFLVGDFSSSAEFFVTIAVFAFLYSLLATVVYIFFQNMYRENNRGPFIDFIVTVVFSFMWLVSSSAWAKGLSDVKVATDPEEVILLISACKVQTNKCSSVYGPIWSGLNTSVVFGYLNFVLWAGNIWFVFKET 221
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Match: sypa (synaptophysin-like [Source:NCBI gene;Acc:103034278])

HSP 1 Score: 112.849 bits (281), Expect = 3.889e-29
Identity = 75/226 (33.19%), Postives = 120/226 (53.10%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTS--LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEP 730
             V K P GFIK LE + AI AF+T   +S   + + +C     +++ I+    YPF +    F    C + ++T    L G+Y S +QFFV + VF  LYS  +   Y+F  E    NNK  L +F ++C+ TF WLV S+ WA  + ++K  T  + + + +  C + +N CR ++E V   L+ S+  GF   +LW  N+WF+ ++T    P +R   + E +P
Sbjct:   11 RVLKVPLGFIKALEWVFAIFAFSTCGSYSGLFRMSVECRNRSESNLKIDVEFEYPFRLHQVYFDAPSC-KGDQTDRFFLVGDYSSSAQFFVTIAVFAFLYSTAALSIYVFAFEKYRENNKAPLIDFGVTCMFTFMWLVSSAAWAKGLSDVKTATDPDKVLELVTACEEESNRCREVREPVMSGLNTSVAFGFLNLILWLGNVWFVFKETGISAPFMRQPPAQEKQP 235
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Match: sypa (synaptophysin-like [Source:NCBI gene;Acc:103034278])

HSP 1 Score: 112.849 bits (281), Expect = 4.127e-29
Identity = 75/226 (33.19%), Postives = 120/226 (53.10%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTS--LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT----PCLRHRYSVEVEP 730
             V K P GFIK LE + AI AF+T   +S   + + +C     +++ I+    YPF +    F    C + ++T    L G+Y S +QFFV + VF  LYS  +   Y+F  E    NNK  L +F ++C+ TF WLV S+ WA  + ++K  T  + + + +  C + +N CR ++E V   L+ S+  GF   +LW  N+WF+ ++T    P +R   + E +P
Sbjct:   14 RVLKVPLGFIKALEWVFAIFAFSTCGSYSGLFRMSVECRNRSESNLKIDVEFEYPFRLHQVYFDAPSC-KGDQTDRFFLVGDYSSSAQFFVTIAVFAFLYSTAALSIYVFAFEKYRENNKAPLIDFGVTCMFTFMWLVSSAAWAKGLSDVKTATDPDKVLELVTACEEESNRCREVREPVMSGLNTSVAFGFLNLILWLGNVWFVFKETGISAPFMRQPPAQEKQP 238
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Match: sypb (synaptophysin b [Source:ZFIN;Acc:ZDB-GENE-040718-205])

HSP 1 Score: 107.457 bits (267), Expect = 4.727e-27
Identity = 71/209 (33.97%), Postives = 114/209 (54.55%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLE-IIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCN--ETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            V K+P GFIK L+ +I AI AF+T   +S   + + +C     + + I     YPF +    F +  C   ETE+   L+G+Y S ++FFV +GVF+ LY++ +   Y+F  E     N+    +FV++ + TFFWLV SS WA  + ++K  T  + +   +  C +  N CR + E V   L+ S+  GF   +LW  N+WF+ ++T
Sbjct:   12 VVKQPLGFIKILQWVIFAIFAFSTCGSYSGIFRMSVECKNRTESDLNIEVEFAYPFRLHQVWFDVPTCKGPETERLF-LEGDYSSSAEFFVTIGVFSFLYTMAAFSIYVFLMEKYREGNRGAQADFVVTALFTFFWLVSSSAWAKGLSDVKKATDPDEVINLIAACDREENRCREVHEPVVSGLNTSVAFGFCNLVLWGGNLWFVFKET 219
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Sea Lamprey
Match: sypl2a (synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-040426-1434])

HSP 1 Score: 94.3597 bits (233), Expect = 1.861e-23
Identity = 63/198 (31.82%), Postives = 102/198 (51.52%), Query Frame = 2 
Query:  107 GFIKFLEIIMAILAFATVSGFSQTIQFNYQC--NMTIMNSIPINYPFAIDSYKFVISLCNETEKTT-SLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            GF+     I +I AFAT  G+S   +    C  N T    I  +YPF ++   F++  C    K   +L G++ S ++FFV + VF  LYS+F+ + Y FY        +  L +FVI+ +  F WLV SS WA  + ++K  T  + +++ + +CQ    C      +   L+ S+V GF   +LW+ N+WF  ++T
Sbjct:    5 GFVP----IFSIFAFATCGGYSGYFEILVNCKNNSTNQTRIDFSYPFRLNQVTFLVPNCTANPKDVGNLYGDFSSSAEFFVTIAVFAFLYSLFALVVYTFYQPKY-QQYRGPLIDFVITALFAFMWLVSSSAWAKGLADVKISTMPDTVYKLISICQEQKICTSGATAIMSSLNVSVVFGFLNLILWSGNVWFAYKET 197
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Sea Lamprey
Match: synpr (synaptoporin [Source:ZFIN;Acc:ZDB-GENE-030616-625])

HSP 1 Score: 80.1073 bits (196), Expect = 5.343e-18
Identity = 48/148 (32.43%), Postives = 80/148 (54.05%), Query Frame = 2 
Query:  260 FVISLCNETE-KTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGI---LSASIVAGFTCFLLWASNIWFLRRDT 691
            F +  C   E +   L G++ S  +F+V V VF  LYS+ + + Y+F  +    NN+  + +F+ + V +F WLV +S WA  + ++K  T  E +   +  CQ        +EG+  +   LS S+V G+  F+LWA NIWF+ ++T
Sbjct:   11 FDVPACKGAEVERLYLTGDFSSSVEFYVTVAVFAFLYSLAAIVVYIFLQQKYTENNRGPMIDFIATVVFSFLWLVSASAWAKGLSDVKSATDPEEVIFLVAACQAAVPLATCKEGLDPVTSGLSVSVVFGYLNFVLWAGNIWFVFKET 158
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Nematostella
Match: EDO44392 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW51])

HSP 1 Score: 92.0485 bits (227), Expect = 4.473e-22
Identity = 65/228 (28.51%), Postives = 111/228 (48.68%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC----NMTIMNSIPINYPFAIDSYKFVISLCNE------TEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNN-------KLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSV 718
            N+FKEP+GFIK +E+ +AI AFAT  G+     +N  C    N T+   + +++ +  D  +  +   N       ++ T  L  NY S+S++FVFVG    LY+I + ++Y F+ + +  +         L + +F +S +   FW   S  WA  +  +K  T           C+  N C  +    +  L+ S++ GF   ++WA N+WFL ++TP    R + 
Sbjct:   11 NIFKEPRGFIKVIELFIAIFAFATTVGYRGNYGYNALCTDKTNKTVTQHVSVDFSYTFDEARVYVDQPNGFKCVNVSQYTQPL--NYKSESEYFVFVGTTCFLYAIGAALYYTFFEDQVKDSTSTDIGICSLPVVDFAVSVLYVIFWFTASIAWAAGLSGLKNATQVGVNVALSTNCRTPNVCNNLTGATFAALNVSVLLGFLNCVVWAFNLWFLFKETPWHSPRRAA 236
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Match: sypl2a (synaptophysin-like protein 2 [Source:NCBI gene;Acc:101158102])

HSP 1 Score: 119.398 bits (298), Expect = 3.474e-32
Identity = 80/225 (35.56%), Postives = 119/225 (52.89%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMT-IMNSI-PI-NYPFAIDSYKFVISLCNETEKT-TSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILP 739
            +D+   KEP GFI+ LE   AI AFAT  G+S T  F  +C  T + N + P+  YPF + S  +VI  CN T    T L G++ S ++FFV VGVF  LY   + + YL +        +  + + V++    F WLV SS W   + ++K+ T+ +++     V Q T+ C   +    G L+AS++ GF   LLWA N WF+ ++TP  +    VE  P  P
Sbjct:   14 LDLGPLKEPIGFIRLLEWFFAIFAFATTGGYSGTTHFKVKCPGTGVENDVNPVFGYPFRLPSKPYVIPSCNSTANNQTYLQGDFSSSAEFFVCVGVFAFLYCTATLVLYLGFQYMYRQTTRGPILDLVVTAAFAFLWLVSSSAWGKGLTDVKWATNPDNL-----VLQCTSVCEPGEFPSLGRLNASVIFGFLNLLLWAGNCWFIYKETPFHKDPIPVEGGPAGP 233
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Match: sypl2b (synaptophysin-like protein 1 [Source:NCBI gene;Acc:101158606])

HSP 1 Score: 115.161 bits (287), Expect = 1.794e-30
Identity = 73/212 (34.43%), Postives = 111/212 (52.36%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPI--NYPFAIDSYKFVISLCNETEKTTS---LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTP 694
            +D+   KEP  FI+ LE + +I AFAT  G+S +  FN QC+      I    +YPF +  + F +  C   + TT+   L GNY S ++F+V VGV   LY   + + YL Y      +++    + +++   TF WL  SS WA  + ++K  TS   I   L+VC    NSC      + G L++S+V GF   +LW  N WF+ ++TP
Sbjct:   15 LDLGPLKEPLAFIRVLEWLFSIFAFATTGGYSGSTSFNLQCSGRAFQEIQTTFSYPFRLMHHSFDVPDCKVNQTTTTVNYLTGNYSSSAEFYVTVGVLAFLYCTATLVLYLGYQHLYRESSRGPTVDLLVTAAFTFLWLTSSSAWAKGLTDVKRATSPTFIITLLEVCLSPGNSCTAGAFPLMGRLNSSVVFGFLNLILWGGNCWFIYKETP 226
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Match: sypl2b (synaptophysin-like protein 1 [Source:NCBI gene;Acc:101158606])

HSP 1 Score: 115.161 bits (287), Expect = 2.330e-30
Identity = 73/212 (34.43%), Postives = 111/212 (52.36%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPI--NYPFAIDSYKFVISLCNETEKTTS---LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVC-QVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTP 694
            +D+   KEP  FI+ LE + +I AFAT  G+S +  FN QC+      I    +YPF +  + F +  C   + TT+   L GNY S ++F+V VGV   LY   + + YL Y      +++    + +++   TF WL  SS WA  + ++K  TS   I   L+VC    NSC      + G L++S+V GF   +LW  N WF+ ++TP
Sbjct:   19 LDLGPLKEPLAFIRVLEWLFSIFAFATTGGYSGSTSFNLQCSGRAFQEIQTTFSYPFRLMHHSFDVPDCKVNQTTTTVNYLTGNYSSSAEFYVTVGVLAFLYCTATLVLYLGYQHLYRESSRGPTVDLLVTAAFTFLWLTSSSAWAKGLTDVKRATSPTFIITLLEVCLSPGNSCTAGAFPLMGRLNSSVVFGFLNLILWGGNCWFIYKETP 230
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Match: sypl1 (synaptophysin-like protein 1 [Source:NCBI gene;Acc:101167334])

HSP 1 Score: 102.064 bits (253), Expect = 1.365e-25
Identity = 73/228 (32.02%), Postives = 120/228 (52.63%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN--YPFAIDSYKFV---ISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTN-SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILPQ 742
            ++++  KEP GFIK +E + AI AF T +GFS     +  C     +++  N  YPF +     +    +LCN T  TT L G+  S  +FFV VG    LYS+ + + YL Y      ++   + +FVI+ +L F WLV SS WA  +  +K  T+ + I   + VC+ +N +C + +      L+ S+V G+   L+WA+N WF+ ++T     +++ +  P   Q
Sbjct:    7 LNLSPLKEPLGFIKLVEWLTAIFAFGTCAGFSGRNTVSLFCGDGRNDTLSANFHYPFRLSLVPLIEGNTTLCNHTVGTTYLVGDASSAVEFFVGVGTVCFLYSMAALLVYLGYMHVYKDSDFGPILDFVITAILVFLWLVCSSAWAKGLQNVKDATNTDGIDATVAVCKGSNVTCAVTEFANMRTLNLSVVFGYLNMLVWAANAWFVYKETRWHSQKFASQSGPGRQQ 234
[Close]
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Match: sypa (synaptophysin [Source:NCBI gene;Acc:101160211])

HSP 1 Score: 102.064 bits (253), Expect = 4.066e-25
Identity = 65/208 (31.25%), Postives = 103/208 (49.52%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPIN----YPFAIDSYKFVISLCNETEKTTS-LDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQV-TNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
             V K P GFIK L+   A+ AF+T   +S  ++    C     + + I     YPF +    F    C + EK    L G++ S ++FFV + VF  LYS  +   Y+F+ E    NNK  L +  ++ V  F WLV S+ WA  + ++K  T  + +   +  C+   N CR + + V   L+ S+  GF   +LW  N+WF+ ++T
Sbjct:   15 RVLKVPLGFIKVLQWFFAVFAFSTCGSYSGLLRVAVDCKNRTESDLKIEVEFEYPFRLHQEYFDAPTCKDGEKEQVFLIGDHSSSAEFFVTIAVFAFLYSTATLSIYIFFFEKYKENNKGPLIDLAVTAVFAFMWLVSSAAWAKGLSDVKTATDPDKVIMMIPACKKEENRCREVHDPVMSGLNTSVAFGFINLVLWVGNLWFVFKET 222
[Close]
BLAST of MARVEL domain-containing protein vs. Planmine SMEST
Match: SMESG000013795.1 (SMESG000013795.1)

HSP 1 Score: 426.402 bits (1095), Expect = 5.720e-153
Identity = 221/223 (99.10%), Postives = 222/223 (99.55%), Query Frame = 2 
Query:   77 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIPINYPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILPQS 745
            MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMT MNSIPINYPFAIDSYKFVISLCNET+KTTSLDGNYVSQSQFFVFVGVFTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILPQS
Sbjct:    1 MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTTMNSIPINYPFAIDSYKFVISLCNETKKTTSLDGNYVSQSQFFVFVGVFTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHRYSVEVEPILPQS 223
[Close]
BLAST of MARVEL domain-containing protein vs. Planmine SMEST
Match: SMESG000010412.1 (SMESG000010412.1)

HSP 1 Score: 129.413 bits (324), Expect = 3.967e-36
Identity = 81/210 (38.57%), Postives = 118/210 (56.19%), Query Frame = 2 
Query:   89 VFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQC--NMTIMNSIPINYPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHLKVCQVT-NSCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDTPCLRHR 709
             FKEPK FIK L+I++ ILAFA  + FS       +C  N TI   +  +YPF I     +   C+       + GNY S SQFFVFVGV T+LY + + I Y+F+ E    N+++   +F+I+ V+   W + S  WA  V ++K+YT  + I Q +  C+    SC  I EG +G L+AS++AGF    LW +N+WFL ++T     R
Sbjct:   10 AFKEPKAFIKILQIVLTILAFALTTNFSSHTNIEVKCSENKTIDIKVNYSYPFKIHDNNLIEKTCDIPNTEIVVFGNYSSNSQFFVFVGVITMLYCLAAIILYVFFSELTYQNDRVPKIDFIITVVIVALWFICSVAWADGVSKLKWYTGSKMIVQSIAFCKRNPQSCITISEGTFGSLNASLIAGFANIALWGANLWFLFKETLWYERR 219
[Close]
BLAST of MARVEL domain-containing protein vs. Planmine SMEST
Match: SMESG000016823.1 (SMESG000016823.1)

HSP 1 Score: 67.0106 bits (162), Expect = 7.149e-13
Identity = 63/207 (30.43%), Postives = 113/207 (54.59%), Query Frame = 2 
Query:   86 NVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNS--IPINYPFAIDSYKFVISLCNETEKTTSLDGNYXXXXXXXXXXXXXTLLYSIFSCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYYTSREHIFQHL--KVCQVTN-SCRMIQEGVYGILSASIVAGFTCFLLWASNIWFLRRDT 691
            +VFKEPKGFIK ++II  I++  ++  F  TIQ N+ C   +  +  +  +YPF + +    I++ N +     L+GNY S S+FFVF+   +L+Y + +   Y+  ++ +  + K+  T+FVI  VLTF W   ++ W+    ++K   + + +   +  K+   +N +C    +  +G     I++ FTCF L    +WFL ++T
Sbjct:    6 DVFKEPKGFIKVIQIIFIIISLISICSFYGTIQLNFTCTDALPENAIVKFSYPFNLKTNN--ITVWNVS--NIPLNGNYESSSEFFVFISAVSLIYCLCALTVYILLNDFLYRDPKIRKTDFVIEAVLTFLWFAIAAAWSDVAVKLKSNLASQSLCSQILAKLSNHSNVTCNGGSDVPFGGAYVGIISSFTCFALMLCGLWFLWKET 208
The following BLAST results are available for this feature:
BLAST of MARVEL domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SYNPR2.286e-3336.54synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507][more]
SYP3.302e-3033.48synaptophysin [Source:HGNC Symbol;Acc:HGNC:11506][more]
SYP3.302e-3033.48synaptophysin [Source:HGNC Symbol;Acc:HGNC:11506][more]
SYNPR6.677e-2835.38synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507][more]
SYNPR7.572e-2835.75synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507][more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sph-13.272e-626.07SynaptoPHysin [Source:UniProtKB/TrEMBL;Acc:O44511... [more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sypl2a6.753e-3233.65synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-04... [more]
sypl2a6.753e-3233.65synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-04... [more]
SYNPR2.597e-3135.58si:dkey-30j16.3 [Source:ZFIN;Acc:ZDB-GENE-141212-2... [more]
sypa1.312e-3033.93synaptophysin a [Source:ZFIN;Acc:ZDB-GENE-031104-2... [more]
sypa1.312e-3033.93synaptophysin a [Source:ZFIN;Acc:ZDB-GENE-031104-2... [more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
agl7.831e-2528.23amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotrans... [more]
sypl13.804e-2434.12synaptophysin-like 1 [Source:NCBI gene;Acc:394679][more]
syp1.076e-2329.74synaptophysin [Source:NCBI gene;Acc:100144928][more]
SYNPR1.003e-1429.53synaptoporin [Source:HGNC Symbol;Acc:HGNC:16507][more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Synpr9.369e-3334.70synaptoporin [Source:MGI Symbol;Acc:MGI:1919253][more]
Syp6.337e-2833.65synaptophysin [Source:MGI Symbol;Acc:MGI:98467][more]
Synpr2.558e-2734.72synaptoporin [Source:MGI Symbol;Acc:MGI:1919253][more]
Sypl7.793e-2632.87synaptophysin-like protein [Source:MGI Symbol;Acc:... [more]
Sypl1.158e-2532.87synaptophysin-like protein [Source:MGI Symbol;Acc:... [more]
back to top
BLAST of MARVEL domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P20488|SYPH_BOVIN1.005e-3035.98Synaptophysin OS=Bos taurus OX=9913 GN=SYP PE=1 SV... [more]
sp|P08247|SYPH_HUMAN1.586e-2933.48Synaptophysin OS=Homo sapiens OX=9606 GN=SYP PE=1 ... [more]
sp|Q5YJC1|SYPH_SPECI1.265e-2832.74Synaptophysin OS=Spermophilus citellus OX=9997 GN=... [more]
sp|Q8TBG9|SYNPR_HUMAN3.636e-2735.75Synaptoporin OS=Homo sapiens OX=9606 GN=SYNPR PE=1... [more]
sp|P07825|SYPH_RAT4.197e-2733.65Synaptophysin OS=Rattus norvegicus OX=10116 GN=Syp... [more]
back to top
BLAST of MARVEL domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2P6L2293.221e-3836.74Synaptophysin OS=Nephila clavipes OX=2585209 GN=NC... [more]
A0A2L2XX871.445e-3134.91Synaptophysin-like protein 2 (Fragment) OS=Paraste... [more]
I3M7391.779e-3136.07Synaptoporin OS=Ictidomys tridecemlineatus OX=4317... [more]
D1LXF42.213e-3130.80Synaptoporin-like protein OS=Saccoglossus kowalevs... [more]
K1RPP17.193e-3137.85Synaptophysin OS=Crassostrea gigas OX=29159 GN=CGI... [more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sypl2b4.884e-3236.79synaptophysin-like protein 2 [Source:NCBI gene;Acc... [more]
si:dkey-30j16.38.615e-3033.17synaptoporin [Source:NCBI gene;Acc:103035011][more]
sypa3.889e-2933.19synaptophysin-like [Source:NCBI gene;Acc:103034278... [more]
sypa4.127e-2933.19synaptophysin-like [Source:NCBI gene;Acc:103034278... [more]
sypb4.727e-2733.97synaptophysin b [Source:ZFIN;Acc:ZDB-GENE-040718-2... [more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
sypl2a1.861e-2331.82synaptophysin-like 2a [Source:ZFIN;Acc:ZDB-GENE-04... [more]
synpr5.343e-1832.43synaptoporin [Source:ZFIN;Acc:ZDB-GENE-030616-625][more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO443924.473e-2228.51Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of MARVEL domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sypl2a3.474e-3235.56synaptophysin-like protein 2 [Source:NCBI gene;Acc... [more]
sypl2b1.794e-3034.43synaptophysin-like protein 1 [Source:NCBI gene;Acc... [more]
sypl2b2.330e-3034.43synaptophysin-like protein 1 [Source:NCBI gene;Acc... [more]
sypl11.365e-2532.02synaptophysin-like protein 1 [Source:NCBI gene;Acc... [more]
sypa4.066e-2531.25synaptophysin [Source:NCBI gene;Acc:101160211][more]
back to top
BLAST of MARVEL domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000013795.15.720e-15399.10SMESG000013795.1[more]
SMESG000010412.13.967e-3638.57SMESG000010412.1[more]
SMESG000016823.17.149e-1330.43SMESG000016823.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021161 ID=SMED30021161|Name=MARVEL domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=861bp
CTAGATCACCTTAATGATATCGTTGTTTAAAACAGATATGACCTTTGTTC
TCAAAACCTTTCCGATTTCAAAATAAATGGATGTCAACGTTTTTAAAGAA
CCAAAGGGATTTATTAAATTTCTTGAAATCATTATGGCGATCTTAGCATT
TGCTACTGTTAGTGGATTTTCACAGACTATTCAATTCAATTATCAGTGCA
ATATGACAATTATGAATTCGATTCCAATTAATTATCCTTTTGCCATAGAT
TCGTATAAATTCGTAATTTCACTTTGCAACGAAACGGAGAAAACTACTTC
TCTCGATGGGAATTACGTTTCACAATCACAATTTTTCGTTTTCGTAGGAG
TCTTTACTCTACTTTATTCGATTTTCAGTTGCATATTTTATTTATTCTAT
CACGAGAATATGTTATCAAATAATAAATTGATATTGACAGAATTTGTTAT
AAGTTGTGTATTGACATTCTTTTGGCTTGTTGGATCGTCTGTTTGGGCCG
GAACGGTCGGAGAAATTAAGTATTATACTAGCCGAGAACATATATTTCAA
CATCTCAAAGTATGCCAAGTAACTAATTCATGTCGTATGATACAGGAAGG
AGTTTATGGAATATTATCCGCATCTATAGTAGCCGGATTTACCTGTTTCT
TATTATGGGCAAGTAATATATGGTTTTTGCGAAGAGATACTCCTTGCTTG
AGACATAGATATTCTGTGGAAGTTGAACCCATATTGCCGCAGTCATAATG
TTATGTACTGATAATTACTTTGAATAAAAATGAAATTTTAATTATTGTGT
ATGAAGAAATTATTTTATTATTTGACAAATAAATAAGAGAACACCATTTT
TAAAAATATTT
back to top

protein sequence of SMED30021161-orf-1

>SMED30021161-orf-1 ID=SMED30021161-orf-1|Name=SMED30021161-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=224bp
MDVNVFKEPKGFIKFLEIIMAILAFATVSGFSQTIQFNYQCNMTIMNSIP
INYPFAIDSYKFVISLCNETEKTTSLDGNYVSQSQFFVFVGVFTLLYSIF
SCIFYLFYHENMLSNNKLILTEFVISCVLTFFWLVGSSVWAGTVGEIKYY
TSREHIFQHLKVCQVTNSCRMIQEGVYGILSASIVAGFTCFLLWASNIWF
LRRDTPCLRHRYSVEVEPILPQS*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001285Synaptophysin/porin
IPR008253Marvel
Vocabulary: molecular function
TermDefinition
GO:0005215transporter activity
Vocabulary: biological process
TermDefinition
GO:0006810transport
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0008021synaptic vesicle
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001285Synaptophysin/synaptoporinPRINTSPR00220SYNAPTOPHYSNcoord: 13..35
score: 39.86
coord: 86..110
score: 40.33
coord: 184..202
score: 43.86
coord: 118..141
score: 43.06
IPR001285Synaptophysin/synaptoporinPANTHERPTHR10306SYNAPTOPHYSINcoord: 2..209
IPR008253Marvel domainPFAMPF01284MARVELcoord: 6..200
e-value: 7.0E-26
score: 91.0
IPR008253Marvel domainPROSITEPS51225MARVELcoord: 5..206
score: 14.683
NoneNo IPR availableTMHMMTMhelixcoord: 15..37
NoneNo IPR availableTMHMMTMhelixcoord: 176..198
NoneNo IPR availableTMHMMTMhelixcoord: 118..140
NoneNo IPR availableTMHMMTMhelixcoord: 86..108