Transmembrane emp24 domain-containing protein

Overview
NameTransmembrane emp24 domain-containing protein
Smed IDSMED30021106
Length (bp)745
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Transmembrane emp24 domain-containing protein (SMED30021106) t-SNE clustered cells

Violin plots show distribution of expression levels for Transmembrane emp24 domain-containing protein (SMED30021106) in cells (dots) of each of the 12 neoblast clusters.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021106

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30021106h1SMcG0018739 SmedASXL_004516SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
parapharyngeal regionSMED30021106h1SMcG0018739 SmedASXL_004516SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
epidermisSMED30021106h1SMcG0018739 dd_Smed_v4_11303_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30021106h1SMcG0018739 dd_Smed_v4_11303_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30021106h1SMcG0018739 dd_Smed_v4_11303_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30021106h1SMcG0018739 OX_Smed_1.0.08570ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Match: TMED2 (transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996])

HSP 1 Score: 159.458 bits (402), Expect = 2.753e-48
Identity = 74/182 (40.66%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Match: TMED2 (transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996])

HSP 1 Score: 122.865 bits (307), Expect = 2.351e-34
Identity = 56/146 (38.36%), Postives = 94/146 (64.38%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVH 571
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK    E           Q+ +  +I+E++V +  +KHE ++++ R ++H
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEGGGDTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIH 165
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Match: TMED2 (transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996])

HSP 1 Score: 84.3445 bits (207), Expect = 2.870e-20
Identity = 43/112 (38.39%), Postives = 74/112 (66.07%), Query Frame = 2 
Query:  371 GKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR
Sbjct:    3 GTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRR 114
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Match: TMED7 (transmembrane p24 trafficking protein 7 [Source:HGNC Symbol;Acc:HGNC:24253])

HSP 1 Score: 71.633 bits (174), Expect = 1.706e-14
Identity = 46/175 (26.29%), Postives = 87/175 (49.71%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIIT-PKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+VI GG+ D++ +L  PD KV+Y+  ++    +TF  ++ G Y++CFSN  +    K V F+  +   P +    P ++ ++ +++M      I HE       +Q H+ +         E+ N  +  W + E   L+ +S+GQV  L+ +F  +R 
Sbjct:   47 QCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPL---FPSENRVSALTQMESACVSI-HEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRT 217
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Match: TMED7-TICAM2 (TMED7-TICAM2 readthrough [Source:HGNC Symbol;Acc:HGNC:33945])

HSP 1 Score: 64.6994 bits (156), Expect = 3.799e-12
Identity = 35/134 (26.12%), Postives = 68/134 (50.75%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIIT-PKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNK 598
            +CF++      +  L F+VI GG+ D++ +L  PD KV+Y+  ++    +TF  ++ G Y++CFSN  +    K V F+  +   P +    P ++ ++ +++M      I HE       +Q H+ + E   +
Sbjct:   47 QCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPL---FPSENRVSALTQMESACVSI-HEALKSVIDYQTHFRLREAQGR 176
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Celegans
Match: sel-9 (Suppressor/enhancer of lin-12 protein 9 [Source:UniProtKB/Swiss-Prot;Acc:O17528])

HSP 1 Score: 154.066 bits (388), Expect = 1.650e-46
Identity = 72/190 (37.89%), Postives = 119/190 (62.63%), Query Frame = 2 
Query:  161 AFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            A S++I ++  E +CFFD+  +  ++ LMFEV EGG++DI++++ GPD K IY+G+RES+GK+TFA +  G Y YCF N M+    K V+F ++I  P   Q+ P             +  ++ E+S  +  +KHE ++++ R +VH  INENTN  +++W   E   L+ +++GQ+ YL+R+FE R  +
Sbjct:   16 AASYFIHVDANEEQCFFDRLTSGTKMGLMFEVAEGGFLDIDVKITGPDNKEIYKGERESSGKFTFAAHMDGVYTYCFGNKMSTMTPKAVMFTVEITEPH--QQAPGAAANQDAADNAKLEEMVRELSSALMSVKHEQEYMEVRERVHRNINENTNSRVVMWAAFEAFVLVGMTVGQIFYLKRFFEVRTMV 203
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Celegans
Match: F57B10.5 (pep chromosome:WBcel235:I:6562699:6563660:1 gene:WBGene00019003.1 transcript:F57B10.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F57B10.5)

HSP 1 Score: 53.5286 bits (127), Expect = 1.385e-8
Identity = 40/177 (22.60%), Postives = 80/177 (45.20%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNM---DIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENT--------NKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++    +   V  F+V+ GG+ D+++ +  P+ KV+Y+  ++      F     G Y+ CFSN  +    KIV  +    D         +   +M  L    +V I D    +      +Q H+ + E T        N+ +++W + + + ++ + +GQV  L+ +F  +R 
Sbjct:   30 QCFYEDLKKDVDTVFEFQVVTGGHYDVDLIIEDPNGKVLYKDTKKQYDSINFKAEVEGTYKACFSNEFSTFSHKIVYMDWQFGDQNALHAAVTQGAHAMTQL-ENYAVAIGDKLRTID----DYQTHHRLREATGRKRAEELNERVMIWSLGQSAVVVFIGIGQVFLLKSFFNDKRT 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Celegans
Match: Y60A3A.9 (pep chromosome:WBcel235:V:19946691:19949093:-1 gene:WBGene00013360.1 transcript:Y60A3A.9.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y60A3A.9)

HSP 1 Score: 52.373 bits (124), Expect = 5.040e-8
Identity = 48/196 (24.49%), Postives = 92/196 (46.94%), Query Frame = 2 
Query:  161 AFSHYIIIEPKETECFFDKAN-----TNDRIVLMFEVIEGGYMD-----INIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYC-FSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIF-------DIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            A S Y  I   E +CF ++       T +  V +++    GY D     +++++  P+ KVI      + G++TF +N PG++  C +SNS    +   +  ++DI      Q   Q +  + ++E+ +RI         I  E  + + R +   + +E+TN  +  W I ++  L      Q+ +LR +FEA++
Sbjct:   14 ADSLYFHIAETEKKCFIEEIPDETMVTGNYKVQLYDPNTKGYGDYPNIGMHVEVKDPEDKVILSKLYTAEGRFTFTSNTPGEHVICIYSNSTAWFNGAQLRVHLDIQAGDHAQDYAQIAQKDKLNELQLRIRQLLDQVDQITKEQNYQRYREERFRQTSESTNSRVFYWSIAQVVVLAITGAWQMRHLRGFFEAKK 209
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Celegans
Match: K08E4.6 (pep chromosome:WBcel235:IV:12077107:12078162:-1 gene:WBGene00010670.1 transcript:K08E4.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:K08E4.6)

HSP 1 Score: 47.7506 bits (112), Expect = 2.344e-6
Identity = 25/82 (30.49%), Postives = 43/82 (52.44%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLM--FEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNM 439
            +CFF   +      L   ++VI+GG ++IN  +      ++ Q   + +G +    NQPG Y+ CF NS + + RK+V F +
Sbjct:   35 QCFFQPVDLAKHKTLEVDYQVIDGGDLNINFMIL-HGANILKQDQLKVDGSHRIELNQPGDYQVCFDNSFSYQSRKVVFFEI 115
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Match: CHOp24 (gene:FBgn0029709 transcript:FBtr0343566)

HSP 1 Score: 130.183 bits (326), Expect = 3.971e-37
Identity = 63/187 (33.69%), Postives = 112/187 (59.89%), Query Frame = 2 
Query:  167 SHYIII--EPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMI------NLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            SH  I+  +    ECFF+      +  + FEVI+GG++D++I++ GPD  V+++ ++ES+GKYTF     G Y  CF+N  +    K+V+F++D+   P+     P +  +      ++I E+S  +  +KHE +++  R ++H  +NENTN  ++LW   E   L+ +++GQV YL+R+FE +R +
Sbjct:   22 SHAFIVSVDAHNEECFFENVEGGTKFGVTFEVIDGGFLDVDIKISGPDNHVMHESEKESSGKYTFVAPAKGTYTVCFNNERSSMTPKLVMFSIDVGDAPQRAPGAPGEEEVGHTKLEDMIRELSGTLTSVKHEQEYMHVRDKIHRSVNENTNSRVVLWSTFEALVLVLMTVGQVYYLKRFFEVKRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Match: CHOp24 (gene:FBgn0029709 transcript:FBtr0070675)

HSP 1 Score: 130.183 bits (326), Expect = 3.971e-37
Identity = 63/187 (33.69%), Postives = 112/187 (59.89%), Query Frame = 2 
Query:  167 SHYIII--EPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMI------NLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            SH  I+  +    ECFF+      +  + FEVI+GG++D++I++ GPD  V+++ ++ES+GKYTF     G Y  CF+N  +    K+V+F++D+   P+     P +  +      ++I E+S  +  +KHE +++  R ++H  +NENTN  ++LW   E   L+ +++GQV YL+R+FE +R +
Sbjct:   22 SHAFIVSVDAHNEECFFENVEGGTKFGVTFEVIDGGFLDVDIKISGPDNHVMHESEKESSGKYTFVAPAKGTYTVCFNNERSSMTPKLVMFSIDVGDAPQRAPGAPGEEEVGHTKLEDMIRELSGTLTSVKHEQEYMHVRDKIHRSVNENTNSRVVLWSTFEALVLVLMTVGQVYYLKRFFEVKRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Match: CG9308 (gene:FBgn0034681 transcript:FBtr0071749)

HSP 1 Score: 109.383 bits (272), Expect = 4.056e-29
Identity = 52/190 (27.37%), Postives = 108/190 (56.84%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII---------TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A    + ++  ET CF+D AN +D++ + FEV+EGG+ D+ +++ GPD   ++   +++ G +TF   + G+Y+ CF N M+    KI++F   +          + +VD    Q ++ ++I+++S ++  +K E +++  R++ H E+++     +L W I     LI  ++ +V YL+ +FE +R +
Sbjct:   14 AACGFIVTLDAHETMCFYDHANVSDKVTVSFEVMEGGFKDVGVEIAGPDDDRLHHSKQDTMGSFTFTAMKEGRYQLCFDNKMSTMTPKILMFQFHVARAIEFYMDSSKRVDDVIEQATVQSMINQLSAKLGAVKMEQEYMHFRYRGHLEVSDMVELRVLAWSIFGPMMLIITAVLEVYYLKHFFEVKRVV 203
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Match: CG31787 (gene:FBgn0051787 transcript:FBtr0081055)

HSP 1 Score: 63.929 bits (154), Expect = 6.841e-12
Identity = 28/104 (26.92%), Postives = 57/104 (54.81%), Query Frame = 2 
Query:  176 IIIEPKETECFFDKANTNDRIVLMFEVIEGGYMD--INIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQD 481
            +  E    ECF+    T + I + ++VI GG  +  IN  L  P ++++    +   GK++   N+ G Y++CF N+++  ++KIV F +++     +++E +D
Sbjct:   33 VFAEAGRQECFYQPIATTENIKIDYQVIHGGLGETHINFNLMDPSRRLLIAETKRQMGKHSIQANETGSYKFCFDNTISTFNQKIVSFTLEVAPADREERELRD 136
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Match: p24-1 (gene:FBgn0030341 transcript:FBtr0073604)

HSP 1 Score: 57.3806 bits (137), Expect = 1.129e-9
Identity = 42/175 (24.00%), Postives = 81/175 (46.29%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDI----ITPKVDQKEPQDSMINLISEMSVR----IFDIK--HEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            +CF+++   N      F+V  GG +D+++ L  P  KVIY  ++ +   + F     G Y  CF N  +    KIV  +  +      P VD+     + +   S+   +    I D +  H ++  + R +      E+ N+ +++W  +E + +I + L Q++ LR +F  R+
Sbjct:   32 DCFYEEIKKNSSAYFEFQVSAGGQLDVDVTLKDPQGKVIYSLEKATFDSHQFVAETTGVYTACFGNQFSAFSHKIVYVDFQVGEEPALPGVDEHATVLTQMETSSQAIHKGLNDILDAQTHHRLREAQGRKRA-----EDLNQRVMVWSSLETAAVIVIGLVQIMVLRNFFTDRK 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Match: tmed2 (transmembrane p24 trafficking protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-269])

HSP 1 Score: 160.229 bits (404), Expect = 9.553e-49
Identity = 74/185 (40.00%), Postives = 127/185 (68.65%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMSLMFEVAEGGFLDIDVKITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNEMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Match: tmed2 (transmembrane p24 trafficking protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-269])

HSP 1 Score: 157.147 bits (396), Expect = 2.002e-47
Identity = 75/192 (39.06%), Postives = 125/192 (65.10%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK    E           Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMSLMFEVAEGGFLDIDVKITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNEMSTMTPKIVMFTIDIGEAPKGQDMETEGGGDSWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Match: tmed7 (transmembrane p24 trafficking protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2570])

HSP 1 Score: 69.3218 bits (168), Expect = 8.432e-14
Identity = 44/175 (25.14%), Postives = 85/175 (48.57%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+V+ GG+ D++ +L  P+  V+Y+  ++    +TF+  + G Y++CFSN  +    K V F+  +   P +    P ++ +  +++M      I HE       +Q H+ +         E+ N  +  W + E   L+ +S+ QVL LR +F  R+ 
Sbjct:   39 QCFYEDITIGTKCTLEFQVVTGGHYDVDCRLEDPEGTVLYKEMKKQYDSFTFSAARNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPL---FPNENRVTALTQMESACVSI-HEALKSVMDYQTHFRLREAQGRSRAEDLNSRVAFWSVGEALILLVVSVSQVLLLRSFFSDRKT 209
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Match: tmed7 (transmembrane p24 trafficking protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2570])

HSP 1 Score: 69.3218 bits (168), Expect = 8.432e-14
Identity = 44/175 (25.14%), Postives = 85/175 (48.57%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+V+ GG+ D++ +L  P+  V+Y+  ++    +TF+  + G Y++CFSN  +    K V F+  +   P +    P ++ +  +++M      I HE       +Q H+ +         E+ N  +  W + E   L+ +S+ QVL LR +F  R+ 
Sbjct:   39 QCFYEDITIGTKCTLEFQVVTGGHYDVDCRLEDPEGTVLYKEMKKQYDSFTFSAARNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPL---FPNENRVTALTQMESACVSI-HEALKSVMDYQTHFRLREAQGRSRAEDLNSRVAFWSVGEALILLVVSVSQVLLLRSFFSDRKT 209
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Match: tmed7 (transmembrane p24 trafficking protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2570])

HSP 1 Score: 69.3218 bits (168), Expect = 8.432e-14
Identity = 44/175 (25.14%), Postives = 85/175 (48.57%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+V+ GG+ D++ +L  P+  V+Y+  ++    +TF+  + G Y++CFSN  +    K V F+  +   P +    P ++ +  +++M      I HE       +Q H+ +         E+ N  +  W + E   L+ +S+ QVL LR +F  R+ 
Sbjct:   39 QCFYEDITIGTKCTLEFQVVTGGHYDVDCRLEDPEGTVLYKEMKKQYDSFTFSAARNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPL---FPNENRVTALTQMESACVSI-HEALKSVMDYQTHFRLREAQGRSRAEDLNSRVAFWSVGEALILLVVSVSQVLLLRSFFSDRKT 209
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Match: tmed2 (transmembrane p24 trafficking protein 2 [Source:NCBI gene;Acc:734103])

HSP 1 Score: 159.458 bits (402), Expect = 3.201e-48
Identity = 74/185 (40.00%), Postives = 127/185 (68.65%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K I++GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFFEQVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIHKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Match: tmed2 (transmembrane p24 trafficking protein 2 [Source:NCBI gene;Acc:734103])

HSP 1 Score: 156.377 bits (394), Expect = 6.080e-47
Identity = 75/192 (39.06%), Postives = 125/192 (65.10%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K I++GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK    E           Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFFEQVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIHKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEGIGESWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Match: serinc2 (serine incorporator 2 [Source:Xenbase;Acc:XB-GENE-968901])

HSP 1 Score: 68.1662 bits (165), Expect = 3.032e-13
Identity = 46/175 (26.29%), Postives = 82/175 (46.86%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+VI GG+ D++ +L  PD  V+Y+  ++    +TF   + G Y++CFSN  +    K V F+  +   P +   E + + +  +    V I    HE       +Q H+ +         E+ N  +  W I E   L+ +S+GQV  L+ +F  +R 
Sbjct:   48 QCFYEDITQGTKCTLEFQVITGGHYDVDCRLEDPDGIVLYKEMKKQYDSFTFTATRNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPLFPNENRATALTQMESSCVSI----HEALKSVIDYQTHFRLREAQGRSRAEDLNSRVAYWSIGEAIILLVVSIGQVFLLKSFFSDKRT 218
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Match: serinc2 (serine incorporator 2 [Source:Xenbase;Acc:XB-GENE-968901])

HSP 1 Score: 67.781 bits (164), Expect = 3.789e-13
Identity = 46/175 (26.29%), Postives = 82/175 (46.86%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+VI GG+ D++ +L  PD  V+Y+  ++    +TF   + G Y++CFSN  +    K V F+  +   P +   E + + +  +    V I    HE       +Q H+ +         E+ N  +  W I E   L+ +S+GQV  L+ +F  +R 
Sbjct:   42 QCFYEDITQGTKCTLEFQVITGGHYDVDCRLEDPDGIVLYKEMKKQYDSFTFTATRNGTYKFCFSNEFSTFTHKTVYFDFQVGDDPPLFPNENRATALTQMESSCVSI----HEALKSVIDYQTHFRLREAQGRSRAEDLNSRVAYWSIGEAIILLVVSIGQVFLLKSFFSDKRT 212
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Match: tmed5 (transmembrane p24 trafficking protein 5 [Source:NCBI gene;Acc:549314])

HSP 1 Score: 56.225 bits (134), Expect = 5.220e-9
Identity = 43/193 (22.28%), Postives = 90/193 (46.63%), Query Frame = 2 
Query:  167 SHYIIIEPK-ETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFN--MDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEI--------------NENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            S Y    P  + ECFF     +  + + ++V++G  +D++  L  P+ +++   +R+S+G ++  T   G Y++CF NS +    K++ F   +D +  + ++ E   S I     + +++ DI   +  +K R     +I               E+  + +  W +  ++ ++ +S  QV  LR  FE +R
Sbjct:   28 SDYTFTLPAGQKECFFQPMKRDATLEIEYQVLDGAGLDVDFSLTSPNGELLLSEERQSDGVHSVET-IDGDYQFCFDNSFSRMSEKVIFFELILDHLNDEGNELEDWKSYITGTDLLDMKLEDILETINSVKGRLTKSAQIQTLLKAFEARDRNLQESNFERVTFWSVFNLTVMVVVSALQVYMLRSLFEDKR 219
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Match: Tmed2 (transmembrane p24 trafficking protein 2 [Source:MGI Symbol;Acc:MGI:1929269])

HSP 1 Score: 159.844 bits (403), Expect = 1.752e-48
Identity = 74/182 (40.66%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Match: Tmed2 (transmembrane p24 trafficking protein 2 [Source:MGI Symbol;Acc:MGI:1929269])

HSP 1 Score: 121.324 bits (303), Expect = 8.183e-34
Identity = 60/140 (42.86%), Postives = 96/140 (68.57%), Query Frame = 2 
Query:  287 QLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            ++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR
Sbjct:   35 RITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRR 174
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Match: Tmed7 (transmembrane p24 trafficking protein 7 [Source:MGI Symbol;Acc:MGI:1913926])

HSP 1 Score: 72.4034 bits (176), Expect = 6.657e-15
Identity = 46/176 (26.14%), Postives = 87/176 (49.43%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIIT-PKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +CF++      +  L F+VI GG+ D++ +L  PD KV+Y+  ++    +TF  ++ G Y++CFSN  +    K V F+  +   P +    P ++ ++ +++M      I HE       +Q H+ +         E+ N  +  W + E   L+ +S+GQV  L+ +F  +R  
Sbjct:   47 QCFYEDITQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASRNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPL---FPSENRVSALTQMESACVSI-HEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSVGQVFLLKSFFSDKRTT 218
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Match: Tmed2 (transmembrane p24 trafficking protein 2 [Source:MGI Symbol;Acc:MGI:1929269])

HSP 1 Score: 64.3142 bits (155), Expect = 6.913e-13
Identity = 38/109 (34.86%), Postives = 64/109 (58.72%), Query Frame = 2 
Query:  401 MNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            M+    KIV+F +DI   PK    E           Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR
Sbjct:    2 MSTMTPKIVMFTIDIGEAPKGQDMETEGGGDSWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRR 110
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Match: Tmed7 (transmembrane p24 trafficking protein 7 [Source:MGI Symbol;Acc:MGI:1913926])

HSP 1 Score: 65.0846 bits (157), Expect = 1.562e-12
Identity = 35/134 (26.12%), Postives = 68/134 (50.75%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIIT-PKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNK 598
            +CF++      +  L F+VI GG+ D++ +L  PD KV+Y+  ++    +TF  ++ G Y++CFSN  +    K V F+  +   P +    P ++ ++ +++M      I HE       +Q H+ + E   +
Sbjct:   47 QCFYEDITQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASRNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPL---FPSENRVSALTQMESACVSI-HEALKSVIDYQTHFRLREAQGR 176
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Match: sp|P49020|TMED2_CRIGR (Transmembrane emp24 domain-containing protein 2 (Fragment) OS=Cricetulus griseus OX=10029 GN=TMED2 PE=1 SV=1)

HSP 1 Score: 161.384 bits (407), Expect = 2.554e-48
Identity = 75/185 (40.54%), Postives = 127/185 (68.65%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   12 TASGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 196
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Match: sp|A7SXK3|TMED_NEMVE (Transmembrane emp24 domain-containing protein OS=Nematostella vectensis OX=45351 GN=v1g194562 PE=3 SV=1)

HSP 1 Score: 160.999 bits (406), Expect = 4.313e-48
Identity = 77/185 (41.62%), Postives = 122/185 (65.95%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKE---PQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            S+  ++I I+    ECF DK  +  ++ L+FEV EGG++DI++++ GPD+KVIY G+RE++GKYTFA +  G Y YCFSN M+    K++ F+MDI   PK   KE     D +  ++S++S  +  +KHE ++++ R ++H  IN+NTN  ++ W   E   L+ ++LGQV YL+R+FE RR +
Sbjct:   19 SSLCYFITIDAHGEECFHDKVTSGTKMGLIFEVAEGGFLDIDVKIIGPDQKVIYSGERETSGKYTFAAHMDGTYNYCFSNKMSTMTPKVLKFSMDIGEAPKDTSKEDNAGHDKLSEMVSQLSEAMTGVKHEQEYMEVRERIHRSINDNTNSRVVWWSFFESLVLVAMTLGQVYYLKRFFEVRRVV 203
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9R0Q3|TMED2_MOUSE (Transmembrane emp24 domain-containing protein 2 OS=Mus musculus OX=10090 GN=Tmed2 PE=1 SV=1)

HSP 1 Score: 159.844 bits (403), Expect = 1.226e-47
Identity = 74/182 (40.66%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q63524|TMED2_RAT (Transmembrane emp24 domain-containing protein 2 OS=Rattus norvegicus OX=10116 GN=Tmed2 PE=1 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 1.322e-47
Identity = 74/182 (40.66%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q15363|TMED2_HUMAN (Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1)

HSP 1 Score: 159.458 bits (402), Expect = 1.322e-47
Identity = 74/182 (40.66%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ I+    ECFF++  +  ++ L+FEV EGG++DI++++ GPD K IY+GDRES+GKYTFA +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   20 GYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Match: A0A1D1VQ92 (GOLD domain-containing protein OS=Ramazzottius varieornatus OX=947166 GN=RvY_13497-1 PE=3 SV=1)

HSP 1 Score: 176.792 bits (447), Expect = 8.464e-52
Identity = 79/186 (42.47%), Postives = 122/186 (65.59%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDI----------ITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            ++++ +EP  +ECFFD+  T  ++ L FEVIEGG+MDI++Q+ GPD K IY G+RE+NGKYTFAT+  G Y+YCFSN M+    K V+F MD+           TP+  Q +  D + N++ ++S  +  +KHE  ++  R ++H  INENTN  +++W   E   ++ +++GQV YL+R+FE RR
Sbjct:   20 AYFVTVEPDSSECFFDRVKTGTKVSLTFEVIEGGFMDIDVQISGPDGKAIYSGERETNGKYTFATHMDGAYQYCFSNKMSTLTTKTVMFTMDLGDAPDPAAVKGTPE-QQHQEHDKLENMVRDLSAALTTVKHEQDYMNVRARIHASINENTNSRVVMWAFFEALIIVAMTVGQVFYLKRFFEVRR 204
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Match: A0A1I8HUD8 (GOLD domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002731g1 PE=3 SV=1)

HSP 1 Score: 173.711 bits (439), Expect = 1.120e-50
Identity = 83/184 (45.11%), Postives = 125/184 (67.93%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQK-----EPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            S  +++I I+  E +CFFD+  +  ++ LMFEV EGG++DI+++L+GPD KV+Y GDRESNGKYTFA +  G Y+YCFSN M+    KIVLF+MDI     D K     E  + +  +I+++S  +  +KHE ++++ R ++H  IN+NTN  ++LW   E   LI +++GQV YL+R+FE RR
Sbjct:   15 SCNAYFITIDANEEQCFFDRVVSGTKMTLMFEVAEGGFLDIDVKLYGPDNKVVYSGDRESNGKYTFAAHMDGIYKYCFSNKMSTMTPKIVLFSMDIGEKPKDSKDMSADEHHNKLEEMINQLSTSLTVVKHEQEYMEVRERIHRSINDNTNSRVVLWSFFEALVLIAMTVGQVFYLKRFFEVRR 198
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Match: A0A2C9JWM8 (GOLD domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106070911 PE=3 SV=1)

HSP 1 Score: 172.555 bits (436), Expect = 4.409e-50
Identity = 84/184 (45.65%), Postives = 126/184 (68.48%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDS----MINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            S+  ++I I+    ECFFDK  +  ++ LMFEV EGG++DI+I+++GPD KVI+ GDRESNGKYTFA +  G Y+YCFSN+M+    KIV+F++DI   PK    E  D+    +  +I+E+S  +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQV YL+R+FE RR
Sbjct:   19 SSEQYFISIDAHAEECFFDKVTSGTKMSLMFEVAEGGFLDIDIKIYGPDGKVIHSGDRESNGKYTFAAHMDGNYKYCFSNAMSTMTPKIVVFSIDIGEKPKDAAGEEGDANQNKLTEMINELSTALTGVKHEQEYMEVRERIHRSINDNTNSRVVLWSFFEALVLVAMTLGQVYYLKRFFEVRR 202
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Match: V9XRM7 (EMP24 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 171.4 bits (433), Expect = 9.076e-50
Identity = 79/181 (43.65%), Postives = 124/181 (68.51%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKE-----PQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
             +YI ++    ECFFD+  +  +++LMFEV+EGG++DI++++FGPD K IY GDRESNGKY F+ +  G Y+YCFSN M+    KI++F+MD+     + KE      Q+ + +++ E+S  + ++KH+ ++L+ R +VH  INENTN  ++LW   E   L+ +++GQV YLRR+FE RR
Sbjct:   19 GYYITVDANSDECFFDRLVSGAKMMLMFEVVEGGFLDIDVKVFGPDGKAIYTGDRESNGKYAFSAHVDGIYKYCFSNKMSTMTPKIIMFSMDVSQKPRENKEMNTDAHQNKLEDMVYELSNSLLNVKHQQEYLEVRERVHRSINENTNSRVVLWSAFEAVLLLSMTIGQVYYLRRFFEVRR 199
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Match: A0A1B6F6W5 (GOLD domain-containing protein OS=Cuerna arida OX=1464854 GN=g.26164 PE=3 SV=1)

HSP 1 Score: 171.014 bits (432), Expect = 1.416e-49
Identity = 80/188 (42.55%), Postives = 122/188 (64.89%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEPQDS------MINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             A S++I ++    ECFFDK     ++ L FE+ EGG++DI++++ GPD KVIYQG+RE++GKYTFA + PGKY YCFSN M+    K+V+F+M++   PK D K   D       M  +I E++  +  +KHE +++  R ++H  INE+TN  ++LW   E   L  +++GQV YL+R+FE RR +
Sbjct:   14 GAESYFITVDAHAEECFFDKVEIGTKLGLTFEISEGGFLDIDVKIVGPDGKVIYQGERETSGKYTFAAHLPGKYTYCFSNQMSTMTPKVVMFDMEVGDAPKTDVKAEGDETADHTKMEEMIKELTTSLTGVKHEQEYMSVRDRIHRSINESTNSRVVLWSFFEAVVLFTMTMGQVYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Match: TMED2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:103022411])

HSP 1 Score: 159.844 bits (403), Expect = 1.537e-48
Identity = 75/192 (39.06%), Postives = 126/192 (65.62%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ ++    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK D  E           Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSVDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGDGMETEVGGGTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Match: TMED2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:103022411])

HSP 1 Score: 159.844 bits (403), Expect = 1.537e-48
Identity = 75/192 (39.06%), Postives = 126/192 (65.62%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP----------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ ++    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK D  E           Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSVDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGDGMETEVGGGTWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 208
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Match: TMED2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:103022411])

HSP 1 Score: 159.073 bits (401), Expect = 2.957e-48
Identity = 75/194 (38.66%), Postives = 126/194 (64.95%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP------------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ ++    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK D  E             Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSVDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGDGMETEGMIGDCSVTAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 210
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:111194998])

HSP 1 Score: 157.532 bits (397), Expect = 1.061e-47
Identity = 72/182 (39.56%), Postives = 125/182 (68.68%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
             +++ ++    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   21 GYFVSVDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEITGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 202
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Match: tmed7 (transmembrane p24 trafficking protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2570])

HSP 1 Score: 66.6254 bits (161), Expect = 6.210e-13
Identity = 44/175 (25.14%), Postives = 84/175 (48.00%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIIT-PKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEIN--------ENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++      +  L F+V+ GG+ D++ +L  PD  V+Y+  ++    +TF   + G Y++CFSN  +    K V F+  +   P +    P ++ +  +++M      I HE       +Q H+ +         E+ N  +  W I E   L+ +S+ QV+ LR +F  ++ 
Sbjct:   43 QCFYEDITIGTKCTLEFQVVTGGHYDVDCRLEDPDGTVLYKEMKKQYDSFTFTAAKNGTYKFCFSNEFSTFTHKTVYFDFQVGEDPPL---FPNENRVTALTQMESACVSI-HEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAFWSIGEAFILLVVSISQVVLLRSFFSDKKT 213
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Match: tmed2 (transmembrane p24 trafficking protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-269])

HSP 1 Score: 121.324 bits (303), Expect = 4.370e-35
Identity = 57/141 (40.43%), Postives = 96/141 (68.09%), Query Frame = 2 
Query:  284 IQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            +Q+ GPD + IY+GDRESNGKYTFA +  G Y++CF N M+    K+V+F +D+  TPK   ++ +  Q+ +  +I+E++  +  +KHE ++++ R ++H  +N+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR
Sbjct:    1 VQITGPDGREIYRGDRESNGKYTFAAHMDGVYKFCFGNKMSTMTPKMVMFTIDMGETPKGQDMETEAHQNKLEEMINELATAMTAVKHEQEYMEVRERIHRSVNDNTNSRVVLWAFFEALVLVAMTLGQIYYLKRFFEVRR 141
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Match: tmed3 (transmembrane p24 trafficking protein 3 [Source:ZFIN;Acc:ZDB-GENE-030131-8335])

HSP 1 Score: 68.1662 bits (165), Expect = 4.940e-14
Identity = 47/182 (25.82%), Postives = 88/182 (48.35%), Query Frame = 2 
Query:  200 ECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEP----QDSMINLISEM------------SVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +CF++  +   ++ L F+VI GG  D++ ++ GP   V+Y  +R+    Y + T Q G Y  CFSN  +    K V F++     +V ++ P    + + +  +++M            SV  +  +H +Q  + RHQ      E  N  + +W I E   L+ + +GQV+ L+ +F  ++ 
Sbjct:   55 QCFYEDIDQGVKVTLDFQVITGGNYDVDCRVKGPHDSVLYNENRKQYDSYAWTTEQRGTYEICFSNEFSTFTHKTVYFDL-----QVGEEAPLFRDEGTRVVALTQMESACVTIHEGLKSVDNYQTQHRLQETQDRHQA-----EVLNSRVNMWSIGETIILVVVGVGQVMLLKSFFSDKKG 226
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Match: tmed5 (transmembrane p24 trafficking protein 5 [Source:ZFIN;Acc:ZDB-GENE-040426-1302])

HSP 1 Score: 65.4698 bits (158), Expect = 4.414e-13
Identity = 43/189 (22.75%), Postives = 88/189 (46.56%), Query Frame = 2 
Query:  182 IEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFN--MDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKAR----HQVHY----------EINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            + P   ECF+        + + ++VI+GG +D++  +  P   V+    R+ +G ++    + G Y  CF NS +    K++ F   +D + P+ ++ E  D+ I+    + +++ D++  +  +KAR    HQ+             + E+    + LW    +  L+ +S  QV  +R  FE +R +
Sbjct:   43 LAPGHRECFYQPVKPGTVVEIEYQVIDGGELDVDFTVTAPSGTVLLAEHRQGDGVHSVDVKEEGDYEICFDNSFSHISEKLIFFEILLDHMQPEEERPEWMDA-ISADHLIGMKLEDLQESLNSVKARLSRSHQIQTVLRAFEARDRNLQESNLARVNLWSAASVLALMGVSALQVYLVRSLFEDKRRV 230
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Match: tmed7 (transmembrane p24 trafficking protein 7 [Source:ZFIN;Acc:ZDB-GENE-040426-2570])

HSP 1 Score: 59.6918 bits (143), Expect = 4.348e-11
Identity = 41/178 (23.03%), Postives = 80/178 (44.94%), Query Frame = 2 
Query:  173 YIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKY--------ILLWVXXXXXXXXXXXXGQVLYLRRYF 682
            ++ +  ++  C F            ++VI GG  D++ ++ GP  +++Y+  R+    + +   + G Y  CFSN  +    K V F+  I   K   K   +  ++L ++M      I HE       +Q H+ + E  ++Y        + LW + E   L+ + +GQV+ L+ +F
Sbjct:   31 HLGLPAQQCRCLFMPIKVGRTCSKEWQVITGGNYDVDCRVEGPSGEILYKEMRKQYDSHVWTAEKKGIYAICFSNEFSTFSHKTVYFDWQIGDEKPVGKASTNGAVSL-TQMESACVTI-HEALKSVISYQTHHRLEEAQDRYQAEHLNSRVTLWSVGETLMLLSVVVGQVMLLKSFF 206
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Match: tmed5 (transmembrane p24 trafficking protein 5 [Source:ZFIN;Acc:ZDB-GENE-040426-1302])

HSP 1 Score: 56.225 bits (134), Expect = 7.145e-10
Identity = 30/123 (24.39%), Postives = 60/123 (48.78%), Query Frame = 2 
Query:  197 TECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFN--MDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKAR 559
            TECF+        + + ++VI+G  MD++  +  P  +V++   R+S G  +    Q G Y +CF NS +    K+V F   +D +  + D K      + +   + +++ D++  +  +K R
Sbjct:   39 TECFYQALTAGASMEVEYQVIDGAGMDVDFSISSPTGQVLFAEYRKSEGLQSVEAKQDGDYMFCFDNSFSHVSEKVVFFEVILDNMEVEKDDKPAWKDFVEVDEIIDMKLEDLQETMDNIKTR 161
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Yeast
Match: EMP24 (Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles [Source:SGD;Acc:S000003168])

HSP 1 Score: 62.3882 bits (150), Expect = 2.134e-12
Identity = 46/183 (25.14%), Postives = 93/183 (50.82%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIE-----GGYMDINIQLFGPDKKVIYQGDRE-SNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEP-QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFE 685
            SA +H +++      CFF+  +  D + + F+  +        +  +  ++GP++  + +  R+ S+G+ T +    G ++YCF N     + K V FN+  +   VD  +P  +++ + + ++S    ++K E  ++  R + H    E+TN  +  W I ++  +I  SL Q+ YLRR+FE
Sbjct:   17 SASAHNVLLPAYGRRCFFEDLSKGDELSISFQFGDRNPQSSSQLTGDFIIYGPERHEVLKTVRDTSHGEITLSAPYKGHFQYCFLNENTGIETKDVTFNIHGVV-YVDLDDPNTNTLDSAVRKLSKLTREVKDEQSYIVIRERTHRNTAESTNDRVKWWSIFQLGVVIANSLFQIYYLRRFFE 198
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Yeast
Match: ERP4 (Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication [Source:SGD;Acc:S000005542])

HSP 1 Score: 46.9802 bits (110), Expect = 5.947e-7
Identity = 30/123 (24.39%), Postives = 62/123 (50.41%), Query Frame = 2 
Query:  200 EC-FFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMI--NLISEMSVRIFDIKHEVQFLKAR 559
            EC ++D ++  D +V+ ++V+ GG  +I+  +  PD  VI    ++ +  +   +   GKY +C SN+     +K+ +  ++     V   E ++ +I  N I E+   +  I   + +L+AR
Sbjct:   37 ECLYYDLSSDKDVLVVSYQVLTGGNFEIDFDITAPDGSVIVTERQKKHSDFLLKSFGIGKYTFCLSNNYGTSPKKVEI-TLEKEKEIVSSHESKEDIIANNAIEEIDRNLNKITKTMDYLRAR 158
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Yeast
Match: ERP2 (Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication [Source:SGD;Acc:S000000005])

HSP 1 Score: 46.2098 bits (108), Expect = 1.046e-6
Identity = 31/126 (24.60%), Postives = 59/126 (46.83%), Query Frame = 2 
Query:  200 EC-FFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRK--IVLFNMDIITPKVDQKEPQDSMI--NLISEMSVRIFDIKHEVQFLKARH 562
            EC ++D    +D + + ++V+ GG  +I+  +  PD  VI    ++    +   +   GKY +CFSN+     +K  I L     +T + +     D +I  N + E+   +  I   + +L+AR 
Sbjct:   42 ECLYYDMVTEDDSLAVGYQVLTGGNFEIDFDITAPDGSVITSEKQKKYSDFLLKSFGVGKYTFCFSNNYGTALKKVEITLEKEKTLTDEHEADVNNDDIIANNAVEEIDRNLNKITKTLNYLRARE 167
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Nematostella
Match: EDO31547 (Transmembrane emp24 domain-containing protein [Source:UniProtKB/Swiss-Prot;Acc:A7SXK3])

HSP 1 Score: 160.999 bits (406), Expect = 1.768e-49
Identity = 77/185 (41.62%), Postives = 122/185 (65.95%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKE---PQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            S+  ++I I+    ECF DK  +  ++ L+FEV EGG++DI++++ GPD+KVIY G+RE++GKYTFA +  G Y YCFSN M+    K++ F+MDI   PK   KE     D +  ++S++S  +  +KHE ++++ R ++H  IN+NTN  ++ W   E   L+ ++LGQV YL+R+FE RR +
Sbjct:   19 SSLCYFITIDAHGEECFHDKVTSGTKMGLIFEVAEGGFLDIDVKIIGPDQKVIYSGERETSGKYTFAAHMDGTYNYCFSNKMSTMTPKVLKFSMDIGEAPKDTSKEDNAGHDKLSEMVSQLSEAMTGVKHEQEYMEVRERIHRSINDNTNSRVVWWSFFESLVLVAMTLGQVYYLKRFFEVRRVV 203
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Nematostella
Match: EDO42051 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2I7])

HSP 1 Score: 67.0106 bits (162), Expect = 1.426e-13
Identity = 45/183 (24.59%), Postives = 89/183 (48.63%), Query Frame = 2 
Query:  182 IEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMIN---LISEMSVRIFDIKHEVQFLKARHQVHYEINEN--------TNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRN 697
            +E    +CF+++   + +  L F+VI GG  D+++ L+  ++K +Y   ++    +TF   QPG Y++CFSN  +    K V F+        ++ +   +M N    +++M      I HE   +   +Q H+ + E+         N+ +  W + E   ++ + + QV  LR++F  RR+
Sbjct:   30 LEDNARQCFYEELKKDAKATLEFQVITGGNYDVDVILYDINEKELYSVQKKQYDSHTFTVEQPGIYKFCFSNEFSTISHKTVYFDF----QSGEETQLTKTMGNHHTALTQMETACVTI-HENLKIAIDYQTHHRLRESQGRDMAEYLNERVQWWSVGESVLIVIVGICQVFILRQFFAERRS 207
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Nematostella
Match: EDO35763 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKI6])

HSP 1 Score: 54.299 bits (129), Expect = 4.956e-9
Identity = 27/155 (17.42%), Postives = 70/155 (45.16%), Query Frame = 2 
Query:  182 IEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDI-----------ITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLW 613
            ++P + +CF++    N  + + ++VIEGG +DI   L  P  K+  +    ++  ++  T + G+Y +CF N+ +    K +  ++ +           I  +  +++  D  +  +  + V +   +H   F+ +     + + ++ +  +  W
Sbjct:   39 VDPGKRDCFYETIKRNVTLDVEYQVIEGGDLDIGFTLQAPSGKIAIEDGHRTDEAHSLVTEEEGEYEFCFDNTFSTVASKAIFADLGVDFEDDIQKMIGIKDENLEEDLHDRFVRTLENVRVDLDKAEHIQNFISSAAARDFRLAKSKDSRVFWW 193
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:101161906])

HSP 1 Score: 161.384 bits (407), Expect = 2.940e-49
Identity = 74/185 (40.00%), Postives = 127/185 (68.65%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEIMGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQNMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 201
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:101161906])

HSP 1 Score: 159.073 bits (401), Expect = 3.339e-48
Identity = 75/191 (39.27%), Postives = 125/191 (65.45%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPKVDQKEP---------QDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK    E          Q+ +  +I+E++V +  +KHE ++++ R ++H  IN+NTN  ++LW   E   L+ ++LGQ+ YL+R+FE RR +
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEIMGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQNMETEGANSWDAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV 207
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:101161906])

HSP 1 Score: 127.872 bits (320), Expect = 2.319e-36
Identity = 55/142 (38.73%), Postives = 98/142 (69.01%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVH 571
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEIMGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQNMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIH 158
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:101161906])

HSP 1 Score: 127.872 bits (320), Expect = 2.319e-36
Identity = 55/142 (38.73%), Postives = 98/142 (69.01%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVH 571
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEIMGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQNMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIH 158
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Match: tmed2 (transmembrane emp24 domain-containing protein 2 [Source:NCBI gene;Acc:101161906])

HSP 1 Score: 127.872 bits (320), Expect = 2.319e-36
Identity = 55/142 (38.73%), Postives = 98/142 (69.01%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDII-TPK---VDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVH 571
            +A  +++ I+    ECF+++ N+  ++ LMFEV EGG++DI++++ GPD K IY+GDRES+GKY+ A +  G Y++CFSN M+    KIV+F +DI   PK   ++ +  Q+ +  +I+E++V +  +KHE ++++ R ++H
Sbjct:   17 TASGYFVSIDAHAEECFYERVNSGTKMGLMFEVAEGGFLDIDVEIMGPDGKQIYKGDRESSGKYSVAAHMDGTYKFCFSNKMSTMTPKIVMFTIDIGEAPKGQNMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIH 158
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Match: SMESG000025949.1 (SMESG000025949.1)

HSP 1 Score: 353.984 bits (907), Expect = 2.572e-125
Identity = 197/200 (98.50%), Postives = 198/200 (99.00%), Query Frame = 2 
Query:  110 MCNXXXXXXXXXXXXXSAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNICRT 709
            MCNY LVYVIIIILIPSAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIFD+KHEVQFLKARHQVHYEINE TNKYILLWVIIEISCLICLSLGQVLYLRRYFEARRNICRT
Sbjct:    1 MCNYQLVYVIIIILIPSAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIFDVKHEVQFLKARHQVHYEINEKTNKYILLWVIIEISCLICLSLGQVLYLRRYFEARRNICRT 200
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Match: SMESG000069470.1 (SMESG000069470.1)

HSP 1 Score: 171.4 bits (433), Expect = 2.524e-53
Identity = 79/181 (43.65%), Postives = 124/181 (68.51%), Query Frame = 2 
Query:  167 SHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKE-----PQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
             +YI ++    ECFFD+  +  +++LMFEV+EGG++DI++++FGPD K IY GDRESNGKY F+ +  G Y+YCFSN M+    KI++F+MD+     + KE      Q+ + +++ E+S  + ++KH+ ++L+ R +VH  INENTN  ++LW   E   L+ +++GQV YLRR+FE RR
Sbjct:   19 GYYITVDANSDECFFDRLVSGAKMMLMFEVVEGGFLDIDVKVFGPDGKAIYTGDRESNGKYAFSAHVDGIYKYCFSNKMSTMTPKIIMFSMDVSQKPRENKEMNTDAHQNKLEDMVYELSNSLLNVKHQQEYLEVRERVHRSINENTNSRVVLWSAFEAVLLLSMTIGQVYYLRRFFEVRR 199
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Match: SMESG000069470.1 (SMESG000069470.1)

HSP 1 Score: 150.984 bits (380), Expect = 7.393e-46
Identity = 71/155 (45.81%), Postives = 108/155 (69.68%), Query Frame = 2 
Query:  245 MFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITPKVDQKE-----PQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            MFEV+EGG++DI++++FGPD K IY GDRESNGKY F+ +  G Y+YCFSN M+    KI++F+MD+     + KE      Q+ + +++ E+S  + ++KH+ ++L+ R +VH  INENTN  ++LW   E   L+ +++GQV YLRR+FE RR
Sbjct:    1 MFEVVEGGFLDIDVKVFGPDGKAIYTGDRESNGKYAFSAHVDGIYKYCFSNKMSTMTPKIIMFSMDVSQKPRENKEMNTDAHQNKLEDMVYELSNSLLNVKHQQEYLEVRERVHRSINENTNSRVVLWSAFEAVLLLSMTIGQVYYLRRFFEVRR 155
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Match: SMESG000026239.1 (SMESG000026239.1)

HSP 1 Score: 150.984 bits (380), Expect = 2.271e-45
Identity = 72/182 (39.56%), Postives = 117/182 (64.29%), Query Frame = 2 
Query:  158 SAFSHYIIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITP-KVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARRNI 700
            SA S +I + P   ECFFD+   +  ++L++EV EGG +DI+ ++  P   ++Y   ++S+ K+TF T   G Y+YCFSN+M+    KI++F++D I+P K D  +    +  ++SE+   +  +KHE ++++ R ++H +INENTN  +LLW I E   LI +S GQV YL+R+FE RR +
Sbjct:   14 SALSFFISVSPNVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKVLDPSGSILYSAVKKSDDKFTFRTKVDGIYKYCFSNTMSSVTNKILMFSLDTISPAKKDSPDSHSKLEEMVSELDKALTTVKHEQEYMETREKIHRKINENTNSRVLLWAIFEACVLIIMSAGQVYYLKRFFEVRRVV 195
[Close]
BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Match: SMESG000078201.1 (SMESG000078201.1)

HSP 1 Score: 93.5893 bits (231), Expect = 3.912e-23
Identity = 55/180 (30.56%), Postives = 94/180 (52.22%), Query Frame = 2 
Query:  176 IIIEPKETECFFDKANTNDRIVLMFEVIEGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMNDKDRKIVLFNMDIITP------KVDQKEPQDS-MINLISEMSVRIFDIKHEVQFLKARHQVHYEINENTNKYILLWVXXXXXXXXXXXXGQVLYLRRYFEARR 694
            I + P   EC FD  N +D++   +EVI GG++DI  +L  P K    + D+ S G Y     Q G Y +C  N    +  K V FN+    P       +  +E ++S +  ++ ++S  +  +K E ++   R Q+H + N + N++ LLW + E+  ++ +S+GQ+ YL+  FE RR
Sbjct:   23 INLNPNSEECLFDYFNKSDKVEFSYEVINGGFLDIESKLLSPMKVEFMRRDKGSYGVYDLVIEQSGLYYFCLINKEGSQVEKTVRFNL-FSEPHYRWERNITSRESKNSDLEEIVHDLSFLMHSVKAESEYSLTREQIHDQANRSANRHFLLWGLFEMVLMVAMSIGQIAYLKHLFEVRR 201
The following BLAST results are available for this feature:
BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TMED22.753e-4840.66transmembrane p24 trafficking protein 2 [Source:HG... [more]
TMED22.351e-3438.36transmembrane p24 trafficking protein 2 [Source:HG... [more]
TMED22.870e-2038.39transmembrane p24 trafficking protein 2 [Source:HG... [more]
TMED71.706e-1426.29transmembrane p24 trafficking protein 7 [Source:HG... [more]
TMED7-TICAM23.799e-1226.12TMED7-TICAM2 readthrough [Source:HGNC Symbol;Acc:H... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sel-91.650e-4637.89Suppressor/enhancer of lin-12 protein 9 [Source:U... [more]
F57B10.51.385e-822.60pep chromosome:WBcel235:I:6562699:6563660:1 gene:W... [more]
Y60A3A.95.040e-824.49pep chromosome:WBcel235:V:19946691:19949093:-1 gen... [more]
K08E4.62.344e-630.49pep chromosome:WBcel235:IV:12077107:12078162:-1 ge... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CHOp243.971e-3733.69gene:FBgn0029709 transcript:FBtr0343566[more]
CHOp243.971e-3733.69gene:FBgn0029709 transcript:FBtr0070675[more]
CG93084.056e-2927.37gene:FBgn0034681 transcript:FBtr0071749[more]
CG317876.841e-1226.92gene:FBgn0051787 transcript:FBtr0081055[more]
p24-11.129e-924.00gene:FBgn0030341 transcript:FBtr0073604[more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmed29.553e-4940.00transmembrane p24 trafficking protein 2 [Source:ZF... [more]
tmed22.002e-4739.06transmembrane p24 trafficking protein 2 [Source:ZF... [more]
tmed78.432e-1425.14transmembrane p24 trafficking protein 7 [Source:ZF... [more]
tmed78.432e-1425.14transmembrane p24 trafficking protein 7 [Source:ZF... [more]
tmed78.432e-1425.14transmembrane p24 trafficking protein 7 [Source:ZF... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmed23.201e-4840.00transmembrane p24 trafficking protein 2 [Source:NC... [more]
tmed26.080e-4739.06transmembrane p24 trafficking protein 2 [Source:NC... [more]
serinc23.032e-1326.29serine incorporator 2 [Source:Xenbase;Acc:XB-GENE-... [more]
serinc23.789e-1326.29serine incorporator 2 [Source:Xenbase;Acc:XB-GENE-... [more]
tmed55.220e-922.28transmembrane p24 trafficking protein 5 [Source:NC... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Tmed21.752e-4840.66transmembrane p24 trafficking protein 2 [Source:MG... [more]
Tmed28.183e-3442.86transmembrane p24 trafficking protein 2 [Source:MG... [more]
Tmed76.657e-1526.14transmembrane p24 trafficking protein 7 [Source:MG... [more]
Tmed26.913e-1334.86transmembrane p24 trafficking protein 2 [Source:MG... [more]
Tmed71.562e-1226.12transmembrane p24 trafficking protein 7 [Source:MG... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P49020|TMED2_CRIGR2.554e-4840.54Transmembrane emp24 domain-containing protein 2 (F... [more]
sp|A7SXK3|TMED_NEMVE4.313e-4841.62Transmembrane emp24 domain-containing protein OS=N... [more]
sp|Q9R0Q3|TMED2_MOUSE1.226e-4740.66Transmembrane emp24 domain-containing protein 2 OS... [more]
sp|Q63524|TMED2_RAT1.322e-4740.66Transmembrane emp24 domain-containing protein 2 OS... [more]
sp|Q15363|TMED2_HUMAN1.322e-4740.66Transmembrane emp24 domain-containing protein 2 OS... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1D1VQ928.464e-5242.47GOLD domain-containing protein OS=Ramazzottius var... [more]
A0A1I8HUD81.120e-5045.11GOLD domain-containing protein OS=Macrostomum lign... [more]
A0A2C9JWM84.409e-5045.65GOLD domain-containing protein OS=Biomphalaria gla... [more]
V9XRM79.076e-5043.65EMP24 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1[more]
A0A1B6F6W51.416e-4942.55GOLD domain-containing protein OS=Cuerna arida OX=... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TMED21.537e-4839.06transmembrane emp24 domain-containing protein 2 [S... [more]
TMED21.537e-4839.06transmembrane emp24 domain-containing protein 2 [S... [more]
TMED22.957e-4838.66transmembrane emp24 domain-containing protein 2 [S... [more]
tmed21.061e-4739.56transmembrane emp24 domain-containing protein 2 [S... [more]
tmed76.210e-1325.14transmembrane p24 trafficking protein 7 [Source:ZF... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmed24.370e-3540.43transmembrane p24 trafficking protein 2 [Source:ZF... [more]
tmed34.940e-1425.82transmembrane p24 trafficking protein 3 [Source:ZF... [more]
tmed54.414e-1322.75transmembrane p24 trafficking protein 5 [Source:ZF... [more]
tmed74.348e-1123.03transmembrane p24 trafficking protein 7 [Source:ZF... [more]
tmed57.145e-1024.39transmembrane p24 trafficking protein 5 [Source:ZF... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3
Match NameE-valueIdentityDescription
EMP242.134e-1225.14Component of the p24 complex; role in misfolded pr... [more]
ERP45.947e-724.39Member of the p24 family involved in ER to Golgi t... [more]
ERP21.046e-624.60Member of the p24 family involved in ER to Golgi t... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO315471.768e-4941.62Transmembrane emp24 domain-containing protein [So... [more]
EDO420511.426e-1324.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO357634.956e-917.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tmed22.940e-4940.00transmembrane emp24 domain-containing protein 2 [S... [more]
tmed23.339e-4839.27transmembrane emp24 domain-containing protein 2 [S... [more]
tmed22.319e-3638.73transmembrane emp24 domain-containing protein 2 [S... [more]
tmed22.319e-3638.73transmembrane emp24 domain-containing protein 2 [S... [more]
tmed22.319e-3638.73transmembrane emp24 domain-containing protein 2 [S... [more]
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BLAST of Transmembrane emp24 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000025949.12.572e-12598.50SMESG000025949.1[more]
SMESG000069470.12.524e-5343.65SMESG000069470.1[more]
SMESG000069470.17.393e-4645.81SMESG000069470.1[more]
SMESG000026239.12.271e-4539.56SMESG000026239.1[more]
SMESG000078201.13.912e-2330.56SMESG000078201.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021106 ID=SMED30021106|Name=Transmembrane emp24 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=745bp
ATTCAATCACATGAAACAACAAAGCAAGAATTATTAACCAATCTGATTAT
TGACACAATTCACCACTTTGTTTTACTGAATAAATTAAAGAAATTCAAAA
AACAGTGAAATGTGCAATTATCCACTTGTATACGTAATCATTATAATATT
AATTCCAAGCGCCTTTTCTCATTATATCATTATCGAACCGAAAGAAACAG
AATGCTTTTTCGACAAAGCAAATACAAATGATAGAATAGTTTTAATGTTT
GAAGTGATCGAAGGAGGTTACATGGATATTAATATTCAGTTATTTGGTCC
GGACAAAAAGGTCATTTACCAAGGGGATCGGGAATCTAATGGGAAATACA
CATTTGCCACGAATCAGCCAGGAAAATATCGGTATTGTTTCAGCAACTCT
ATGAATGATAAAGACAGGAAAATTGTTCTATTCAATATGGATATAATAAC
TCCAAAAGTAGATCAAAAAGAACCCCAGGATTCAATGATCAACCTAATAT
CGGAAATGAGCGTGAGAATATTTGATATCAAGCATGAAGTGCAATTCCTG
AAAGCCCGTCACCAGGTCCATTATGAAATTAATGAAAATACGAACAAATA
CATTTTACTGTGGGTCATCATAGAGATCAGCTGTCTGATCTGTTTGTCTC
TTGGTCAAGTTTTGTATTTACGGAGATATTTTGAAGCCAGAAGAAACATT
TGCAGGACTTAATATTTCAATAATTTCAGTTTTCTACTATTGTCC
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protein sequence of SMED30021106-orf-1

>SMED30021106-orf-1 ID=SMED30021106-orf-1|Name=SMED30021106-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=201bp
MCNYPLVYVIIIILIPSAFSHYIIIEPKETECFFDKANTNDRIVLMFEVI
EGGYMDINIQLFGPDKKVIYQGDRESNGKYTFATNQPGKYRYCFSNSMND
KDRKIVLFNMDIITPKVDQKEPQDSMINLISEMSVRIFDIKHEVQFLKAR
HQVHYEINENTNKYILLWVIIEISCLICLSLGQVLYLRRYFEARRNICRT
*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000418head
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR015720TMP21-related
IPR036598GOLD_dom_sf
IPR009038GOLD_dom
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0015031protein transport
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
GO:0030659cytoplasmic vesicle membrane
GO:0031410cytoplasmic vesicle
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR009038GOLD domainSMARTSM01190EMP24_GP25L_2coord: 20..192
e-value: 4.7E-52
score: 188.9
IPR009038GOLD domainPFAMPF01105EMP24_GP25Lcoord: 21..192
e-value: 7.0E-40
score: 136.9
IPR009038GOLD domainPROSITEPS50866GOLDcoord: 30..112
score: 20.212
NoneNo IPR availablePANTHERPTHR22811:SF31TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 2coord: 9..193
NoneNo IPR availableSIGNALP_EUKSignalP-TMSignalP-TMcoord: 1..20
score: 0.545
NoneNo IPR availableTMHMMTMhelixcoord: 165..187
NoneNo IPR availableTMHMMTMhelixcoord: 7..25
IPR015720TMP21-relatedPANTHERPTHR22811TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEINcoord: 9..193
IPR036598GOLD domain superfamilySUPERFAMILYSSF101576Supernatant protein factor (SPF), C-terminal domaincoord: 29..118