FMRFamide-activated amiloride-sensitive sodium channel
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021102 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600]) HSP 1 Score: 61.2326 bits (147), Expect = 3.925e-9 Identity = 77/356 (21.63%), Postives = 129/356 (36.24%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESE---TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
Y NC+ F + A F L+++L DI D P +T G L LH + +YP I EG+ + GT T I + M P+ C+ N + + + + YS +C + Q +I+ CNC YL +P+ R KY + D F + C S+ + ++ + CK C Y +IS A WP+++ S D + L +E+ + N+T + ++ + + F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 269 YGNCYIFNWGMTEKALPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL--------------------YPLPRG-EKYCNNRD----FPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEA------------------------SEDWIFHV----------------LSQER------DQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600]) HSP 1 Score: 61.2326 bits (147), Expect = 4.203e-9 Identity = 77/356 (21.63%), Postives = 129/356 (36.24%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESE---TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
Y NC+ F + A F L+++L DI D P +T G L LH + +YP I EG+ + GT T I + M P+ C+ N + + + + YS +C + Q +I+ CNC YL +P+ R KY + D F + C S+ + ++ + CK C Y +IS A WP+++ S D + L +E+ + N+T + ++ + + F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 242 YGNCYIFNWGMTEKALPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL--------------------YPLPRG-EKYCNNRD----FPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEA------------------------SEDWIFHV----------------LSQER------DQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 518
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: SCNN1B (sodium channel epithelial 1 beta subunit [Source:HGNC Symbol;Acc:HGNC:10600]) HSP 1 Score: 61.2326 bits (147), Expect = 4.762e-9 Identity = 77/356 (21.63%), Postives = 129/356 (36.24%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESE---TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
Y NC+ F + A F L+++L DI D P +T G L LH + +YP I EG+ + GT T I + M P+ C+ N + + + + YS +C + Q +I+ CNC YL +P+ R KY + D F + C S+ + ++ + CK C Y +IS A WP+++ S D + L +E+ + N+T + ++ + + F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 314 YGNCYIFNWGMTEKALPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL--------------------YPLPRG-EKYCNNRD----FPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEA------------------------SEDWIFHV----------------LSQER------DQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 590
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: ASIC2 (acid sensing ion channel subunit 2 [Source:HGNC Symbol;Acc:HGNC:99]) HSP 1 Score: 56.9954 bits (136), Expect = 6.468e-8 Identity = 87/360 (24.17%), Postives = 146/360 (40.56%), Query Frame = 1
Query: 187 EKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRI-IKSSNPKQRLLWTFFVAVFFIACVTCVGLL-------VSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLT-SRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDP----NDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNC 1185
E P + + SS Q+ F T++L G+ I + +R+LW +A V +GLL VS Y +Y + + V QS FP++T+CNL SR L N++ A E + L L+ L P + + N Y PK + +GH +M+L C G C + +TV Y C+ F ++ LE++L DI+ + P+ T+ T G + +HS+ P I+ G + PG T + + + + PP G+C ++ +M + F F YS ++C+ + +++ CNC
Sbjct: 5 ESPSEGSLQPSSIQI-------FANTSTLHGIRHIFVYGPLTIRRVLWA-------VAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSR----LTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHY---KPKQFSMLEFLHRVGHDLKDMMLYCKF--------KGQECGH--QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML------DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDF----FPVYSITACRIDCETRYIVENCNC 322
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Match: ASIC2 (acid sensing ion channel subunit 2 [Source:HGNC Symbol;Acc:HGNC:99]) HSP 1 Score: 50.8322 bits (120), Expect = 7.470e-6 Identity = 79/338 (23.37%), Postives = 139/338 (41.12%), Query Frame = 1
Query: 286 RIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVS----------QYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLT----SRG--------IQILLKNNILTAREFIQRL---KTQLRSYKKKLTPIQSKLVTTSW-NLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNC 1185
R + ++R LW +A T GLL+S + ++ +H+ +++ PFP++TVCN PL S+G + +LL N TAR + L R + +KL + L + ++ F++ LGH +M+LSC YR G C S+V Y C+ F ++ LE++L DI+ + P+ T+ T G + +HS+ P I+ G + PG T + + + + PP G+C ++ +M + F YS ++C+ + +++ CNC
Sbjct: 76 RTAAGGSFQRRALWV-------LAFCTSFGLLLSWSSNRLLYWLSFPSHTRVHRE---WSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNR--TARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMD--------RLGHQLEDMLLSCK--YR------GELCGPHN--FSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML------DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDFFP---VYSITACRIDCETRYIVENCNC 373
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: mec-10 (Degenerin mec-10 [Source:UniProtKB/Swiss-Prot;Acc:P34886]) HSP 1 Score: 54.6842 bits (130), Expect = 1.813e-7 Identity = 31/123 (25.20%), Postives = 62/123 (50.41%), Query Frame = 1
Query: 214 LSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKK 582
LS ++ I+ H +FC TS G+P + ++ N R W F + + I + ++ +Y+ D I + ++ + PFP++T+CNL P K++++ + + I ++ +S KK
Sbjct: 87 LSYRERIRWHLQQFCYKTSSHGIPMLGQAPNSLYRAAWVFLLLICAIQFINQAVAVIQKYQKMDKITDIQLKFDTA-PFPAITLCNLNP---------YKDSVIRSHDSISKILGVFKSVMKK 199
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: mec-4 (Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:P24612]) HSP 1 Score: 51.9878 bits (123), Expect = 1.336e-6 Identity = 71/367 (19.35%), Postives = 128/367 (34.88%), Query Frame = 1
Query: 739 SGAACEKVGKWVSTVSKIYHNCHTFIVNEAY------TNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
+G AC+ +++ + + +C TF N + L M++Y + D P T+ TG L +H + +P +T G + G ++ R+ S + P+G C + S + ++YS C + QQ ++K+C C D RFPV N + + I K + ++ + +C+ PC Y + S AKWP+ S + + + +E K KE +++ F EQ + ++ E + L+ GG L +W GI+F E +F+
Sbjct: 453 NGKACDIEADFLTHIDPAFGSCFTFNHNRTVNLTSIRAGPMYGLRMLVY------VNASDYMP---TTEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTS-DYIYSNYEYSVEGCYRSCFQQLVLKECRCGD--------------------PRFPVPENARHCDAADPIARKCLDARM--NDLGGLHGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQ-----------------IQLGSCNGTAVECNK-------------HYKENGAMVE--------VFYEQ-----------LNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFL 738
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: mec-4 (Degenerin mec-4 [Source:UniProtKB/Swiss-Prot;Acc:P24612]) HSP 1 Score: 51.9878 bits (123), Expect = 1.336e-6 Identity = 71/367 (19.35%), Postives = 128/367 (34.88%), Query Frame = 1
Query: 739 SGAACEKVGKWVSTVSKIYHNCHTFIVNEAY------TNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
+G AC+ +++ + + +C TF N + L M++Y + D P T+ TG L +H + +P +T G + G ++ R+ S + P+G C + S + ++YS C + QQ ++K+C C D RFPV N + + I K + ++ + +C+ PC Y + S AKWP+ S + + + +E K KE +++ F EQ + ++ E + L+ GG L +W GI+F E +F+
Sbjct: 453 NGKACDIEADFLTHIDPAFGSCFTFNHNRTVNLTSIRAGPMYGLRMLVY------VNASDYMP---TTEATGVRLTIHDKEDFPFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTS-DYIYSNYEYSVEGCYRSCFQQLVLKECRCGD--------------------PRFPVPENARHCDAADPIARKCLDARM--NDLGGLHGSFRCRCQQPCRQSIYSVTYSPAKWPSLSLQ-----------------IQLGSCNGTAVECNK-------------HYKENGAMVE--------VFYEQ-----------LNFEMLTESEAYGFVNLLADFGGQLGLWCGISFLTCCEFVFLFL 738
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 51.2174 bits (121), Expect = 2.046e-6 Identity = 52/231 (22.51%), Postives = 95/231 (41.13%), Query Frame = 1
Query: 793 YHNCHTFIVN---EAYTNRT---FSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILD---QCKSPCTYFTYDTSISSAKWPAKSYHTM 1458
+ NC+TF N E ++R + L ++LY + E + T+ G + +H + P + G + G ++ +++ +EPP+G C + + +F F+YS +C + Q+ +++ C C D + P M+ K C+ ++ D E N T E S+ + C PC Y+ + SSA+WP+ S M
Sbjct: 403 FGNCYTFNYNRTAEVASHRAGANYGLRVLLYANVSEYLP---------TTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPM-YPVAEMFGNN-TKPCQ-------------AVNMDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKVM 609
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Match: unc-105 (Degenerin-like protein unc-105 [Source:UniProtKB/Swiss-Prot;Acc:Q09274]) HSP 1 Score: 51.2174 bits (121), Expect = 2.046e-6 Identity = 52/231 (22.51%), Postives = 95/231 (41.13%), Query Frame = 1
Query: 793 YHNCHTFIVN---EAYTNRT---FSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILD---QCKSPCTYFTYDTSISSAKWPAKSYHTM 1458
+ NC+TF N E ++R + L ++LY + E + T+ G + +H + P + G + G ++ +++ +EPP+G C + + +F F+YS +C + Q+ +++ C C D + P M+ K C+ ++ D E N T E S+ + C PC Y+ + SSA+WP+ S M
Sbjct: 403 FGNCYTFNYNRTAEVASHRAGANYGLRVLLYANVSEYLP---------TTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPM-YPVAEMFGNN-TKPCQ-------------AVNMDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKVM 609
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic1c (acid-sensing (proton-gated) ion channel 1c [Source:NCBI gene;Acc:407670]) HSP 1 Score: 52.373 bits (124), Expect = 1.323e-6 Identity = 111/568 (19.54%), Postives = 194/568 (34.15%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPK-QRLLWTF-FVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMF--IL---IFDSLFVKEKPLKHSEE 1875
F ++L G+ I + +R LWT F+ + C+ V Y + + + V + FP++T CNL I KN++ E + L + L P L+ + N + PK + D GH + M+L C+ G C + +T+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + E K C L F VE++ N C +PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +L I S+ K +P + + +
Sbjct: 23 FANNSTLHGMSHIFAYGHMTFRRFLWTLSFMGSLGLLMYVCMDR-VYYYFEFPHVTKLDEVAAPNLTFPAVTFCNLNEFRFSKIT---KNDLYHVGELLALLNENYQIANPHLADPEVLTLLKEKASFNGF---KPKQFNMTDFYNRTGHDINEMLLQCSF--------RGEECFPLN--FTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLLYLPPPWGDCR-----SAPMDSEYFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPEQYKDCADPALDFLVEKD-----------------------------NDYCVCDTPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYITDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVLKDKILGSVLRKRRPHRSASD 481
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic2 (acid-sensing (proton-gated) ion channel 2 [Source:NCBI gene;Acc:407669]) HSP 1 Score: 52.373 bits (124), Expect = 1.329e-6 Identity = 88/389 (22.62%), Postives = 147/389 (37.79%), Query Frame = 1
Query: 382 VSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDPND----LGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF-IVNEAYTNRTF-------SLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMW-AKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKR 1491
++ + +Y + V + S FP++TVCNL L +N++ A E + L L+ + L P +T N Y PK + +GH M+L C G C + TV Y C+ F E T RT LE++L DI+ + P+ T+ T G + +HS+ P + G + PG T + + + + PP G+C +S + D+ F+ YS S+C+ + + +++ CNC + +P + + E K C V N C+SPC Y+ +S K P+K+ +Y+E+K R
Sbjct: 85 LAYFLSYPHVTSVDAVVSGSLVFPAVTVCNLNAYR---FTRLTQNDLYHAGELLALLDVHLQIPEPHLAEPHVLAFLTEKSNFTNY---RPKPFSMREFTERVGHDLKEMMLYCRF--------QGQECSH--QDFKTVFTRYGKCYMFNAAEEGKTLRTTMKGGTGNGLEIML------DIQQDEYLPVWGETEETAFEAGVRVQIHSQAEPPFVHELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-----VSRALDSGLFQVYSVSACRIECETRYIVENCNC-RMVYMPGDSPYCTPEQYKDCAEPALAALSAVEGTNCI---------------------------CRSPCNMTRYNKELSMVKIPSKTS----ARYLEKKFNR 414
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Match: asic2 (acid-sensing (proton-gated) ion channel 2 [Source:NCBI gene;Acc:407669]) HSP 1 Score: 52.373 bits (124), Expect = 1.329e-6 Identity = 88/389 (22.62%), Postives = 147/389 (37.79%), Query Frame = 1
Query: 382 VSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDPND----LGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF-IVNEAYTNRTF-------SLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMW-AKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKR 1491
++ + +Y + V + S FP++TVCNL L +N++ A E + L L+ + L P +T N Y PK + +GH M+L C G C + TV Y C+ F E T RT LE++L DI+ + P+ T+ T G + +HS+ P + G + PG T + + + + PP G+C +S + D+ F+ YS S+C+ + + +++ CNC + +P + + E K C V N C+SPC Y+ +S K P+K+ +Y+E+K R
Sbjct: 85 LAYFLSYPHVTSVDAVVSGSLVFPAVTVCNLNAYR---FTRLTQNDLYHAGELLALLDVHLQIPEPHLAEPHVLAFLTEKSNFTNY---RPKPFSMREFTERVGHDLKEMMLYCRF--------QGQECSH--QDFKTVFTRYGKCYMFNAAEEGKTLRTTMKGGTGNGLEIML------DIQQDEYLPVWGETEETAFEAGVRVQIHSQAEPPFVHELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-----VSRALDSGLFQVYSVSACRIECETRYIVENCNC-RMVYMPGDSPYCTPEQYKDCAEPALAALSAVEGTNCI---------------------------CRSPCNMTRYNKELSMVKIPSKTS----ARYLEKKFNR 414
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: ASIC1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:100489966]) HSP 1 Score: 53.9138 bits (128), Expect = 6.562e-7 Identity = 98/428 (22.90%), Postives = 160/428 (37.38%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPK-QRLLWTF-FVAVFFIACVTCVGLLVSQYR-----AYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRT----------FSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPL-KICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKS 1446
F ++L G+ I +RL+W F+ + C ++ + D I PR + FP++T CNL + KN++ A E + L + Y+ + + + V F N PK + + GH M+LSC YR G C V +V ++ Y C+TF N R+ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + + PP G C S + D+E F YS S+C+ + L++ CNC + +P + + L K C L F VE++ N C++PC Y +S K P+K+
Sbjct: 23 FASGSTLHGLAHIFTYERFSCRRLIWVLCFLGSLSLLLYVCTERIIYYFEYPHVTKLDEISTPRMI------FPAVTFCNLNEFR---FSRVTKNDLYHAGELLSLLNNR---YELPDSQLADEKVMEILQDKANFRNFKPKPFNMREFYDRTGHDIREMLLSCK--YR------GEEC-SVDDFVPVFTR-YGKCYTF--NSGRNGRSPLVTTKGGTGNGLELML------DIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCK-----SSAMDSEFFDTYSISACRIDCETRYLVENCNC-RMVHMPGDAAYCTPELYKECADPALDFLVEKD-----------------------------NDFCVCETPCNMTRYGKELSMVKIPSKA 385
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: ASIC1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:100489966]) HSP 1 Score: 53.9138 bits (128), Expect = 6.936e-7 Identity = 98/428 (22.90%), Postives = 160/428 (37.38%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPK-QRLLWTF-FVAVFFIACVTCVGLLVSQYR-----AYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRT----------FSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPL-KICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKS 1446
F ++L G+ I +RL+W F+ + C ++ + D I PR + FP++T CNL + KN++ A E + L + Y+ + + + V F N PK + + GH M+LSC YR G C V +V ++ Y C+TF N R+ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + + PP G C S + D+E F YS S+C+ + L++ CNC + +P + + L K C L F VE++ N C++PC Y +S K P+K+
Sbjct: 20 FASGSTLHGLAHIFTYERFSCRRLIWVLCFLGSLSLLLYVCTERIIYYFEYPHVTKLDEISTPRMI------FPAVTFCNLNEFR---FSRVTKNDLYHAGELLSLLNNR---YELPDSQLADEKVMEILQDKANFRNFKPKPFNMREFYDRTGHDIREMLLSCK--YR------GEEC-SVDDFVPVFTR-YGKCYTF--NSGRNGRSPLVTTKGGTGNGLELML------DIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCK-----SSAMDSEFFDTYSISACRIDCETRYLVENCNC-RMVHMPGDAAYCTPELYKECADPALDFLVEKD-----------------------------NDFCVCETPCNMTRYGKELSMVKIPSKA 382
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: lhx1 (LIM homeobox 1 [Source:Xenbase;Acc:XB-GENE-482482]) HSP 1 Score: 52.7582 bits (125), Expect = 9.310e-7 Identity = 66/282 (23.40%), Postives = 118/282 (41.84%), Query Frame = 1
Query: 259 ETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACV--TCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRP--LTSRGIQILLKNNIL-TAREFIQRLKTQLRSYKKKLTP---IQSKLVTTSWN-LNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYRE--GIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNR----------------TFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEI 1023
+ TS G+P I +S + +R++W FV+ F + C C ++++ Y Y + + + FP++T+CNL L+S G + N++ + E R RS+ +T ++ L +++N + F LP ++GH +M++ C +E + SG K G NC+TF ++ R + L + L++ E + + T G L +H + P E EG+N+ PG TEI
Sbjct: 36 QHTSAHGIPNIFRSKHWFRRMVWLVFVS-FALCCALWQCTQMVLT-YYTYPSHEKIMLISSAKLKFPAVTICNLNSVRLSSLGRSFSMSNSLQDSGLEMTHRRN---RSHHMNVTSDSVDENVLYASAFNKFASEFNQLPDE-QKIEMGHQLEDMLIFCNFHGQECNSSFFSGFINYKFG-----------NCYTFNSQKSVDIRGNQIRVDPLNITKAGFMYGLHLELFIQQIEYV--------RDMTHAAGIRLLVHDQAQMPFPEDEGVNVPPGAETEI 292
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: ASIC1 (acid sensing ion channel subunit 1 [Source:NCBI gene;Acc:100489966]) HSP 1 Score: 52.7582 bits (125), Expect = 1.420e-6 Identity = 81/338 (23.96%), Postives = 132/338 (39.05%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPK-QRLLWTF-FVAVFFIACVTCVGLLVSQYR-----AYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRT----------FSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNC 1185
F ++L G+ I +RL+W F+ + C ++ + D I PR + FP++T CNL + KN++ A E + L + Y+ + + + V F N PK + + GH M+LSC YR G C V +V ++ Y C+TF N R+ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + + PP G C S + D+E F YS S+C+ + L++ CNC
Sbjct: 20 FASGSTLHGLAHIFTYERFSCRRLIWVLCFLGSLSLLLYVCTERIIYYFEYPHVTKLDEISTPRMI------FPAVTFCNLNEFR---FSRVTKNDLYHAGELLSLLNNR---YELPDSQLADEKVMEILQDKANFRNFKPKPFNMREFYDRTGHDIREMLLSCK--YR------GEEC-SVDDFVPVFTR-YGKCYTF--NSGRNGRSPLVTTKGGTGNGLELML------DIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPPWGDCK-----SSAMDSEFFDTYSISACRIDCETRYLVENCNC 322
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Match: scnn1b (sodium channel, non voltage gated 1 beta subunit [Source:NCBI gene;Acc:779891]) HSP 1 Score: 51.9878 bits (123), Expect = 2.899e-6 Identity = 40/134 (29.85%), Postives = 64/134 (47.76%), Query Frame = 1
Query: 235 KSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKN---NILTAREFIQ-RLKTQLRSYKKKLTPIQSKLVTTSWN 624
K + FC+ T+ G RIIK PK+R++W VF G+L+ Y +Y V ++ ++ FP++TVCN P ++ LLK+ + TA + IQ + Q ++ + T L T WN
Sbjct: 31 KELLVWFCDNTNTHGPKRIIKEG-PKKRVMWFILTLVFAGLVFWQWGVLILTYLSYGV-SVSLSIGFKTMEFPAVTVCNANPYKYSRVKPLLKDLDALVATALDRIQFSSQDQANTFTQSSTNQNVTLDPTLWN 162
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Asic2 (acid-sensing (proton-gated) ion channel 2 [Source:MGI Symbol;Acc:MGI:1100867]) HSP 1 Score: 57.7658 bits (138), Expect = 2.828e-8 Identity = 87/360 (24.17%), Postives = 146/360 (40.56%), Query Frame = 1
Query: 187 EKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRI-IKSSNPKQRLLWTFFVAVFFIACVTCVGLL-------VSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLT-SRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDP----NDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNC 1185
E P + + SS Q+ F T++L G+ I + +R+LW +A V +GLL VS Y +Y + + V QS FP++T+CNL SR L N++ A E + L L+ L P + + N Y PK + +GH +M+L C G C + +TV Y C+ F ++ LE++L DI+ + P+ T+ T G + +HS+ P I+ G + PG T + + + + PP G+C ++ +M + F F YS ++C+ + +++ CNC
Sbjct: 5 ESPSEGSLQPSSIQI-------FANTSTLHGIRHIFVYGPLTIRRVLWA-------VAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSR----LTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHY---KPKQFSMLEFLHRVGHDLKDMMLYCKF--------KGQECGH--QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML------DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDF----FPVYSITACRIDCETRYIVENCNC 322
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Match: Scnn1b (sodium channel, nonvoltage-gated 1 beta [Source:MGI Symbol;Acc:MGI:104696]) HSP 1 Score: 53.9138 bits (128), Expect = 5.318e-7 Identity = 77/350 (22.00%), Postives = 121/350 (34.57%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFE 1812
Y NC+ F + A F L+++L DI D P +T GA L LH + TYP I EG+ + GT T I + P+ C+ N + + + YS +C Q +I+ C+C YL E K C FP + N+ + T R C L CK C Y +IS A WP+++ S D ++ L +E+ + N+T + ++ + + F+ +EE ++ LS GG W G + C++E E
Sbjct: 267 YGNCYIFNWGMTEETLPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYP------LPEGEKYCNNRDFP-DWAYCYLNLQMSV----TQRETC-----------LSMCKESCNDTQYKMTISMADWPSEA------------------------SEDWILHV----------------LSQER------DQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGE 540
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q25011|FANA_CORAP (FMRFamide-activated amiloride-sensitive sodium channel OS=Cornu aspersum OX=6535 PE=2 SV=1) HSP 1 Score: 77.7962 bits (190), Expect = 1.278e-13 Identity = 108/540 (20.00%), Postives = 211/540 (39.07%), Query Frame = 1
Query: 265 TSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKN----NILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIAT--------QLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYL--QVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKF-----TNRTKCESE-----TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEX---------XXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGIT 1785
++ G+ +I+ S + K++++W V F A + LLV +Y + V+ + +PS+++CN+ P++ R I+ + N N++T FIQ+ + + S+ ++ ++ NL + D L H+ +M++ C RE C V + + Y NC TF + E L L +E D P G + +H+ G+ P G+++ PG + + + + P+G C+ ++ + +Q+KY+ +C Q Q+ +I++C C +VP+ C ++ E N N + E+ T CE R + + C PC+ +Y S+S + WP + Y V+ K +R K++ +E ++ + L E++ +A++L+R QN+L + + + + + L + GG L +W GI+
Sbjct: 50 SNAHGLAKIVTSRDTKRKVIWALLVIAGFTAATLQLSLLVRKYLQFQVVELSEIKDSMPVQYPSVSICNIEPISLRTIRRMYFNNESQNLITWLRFIQKFRFEQDSFMN--------------SIRAFYENLGQ--DAKKLSHNLEDMLMHCRF-NRE-------LCH-VSNFSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSL--IFSVEKDDPLPGTYGVYNFDNNILHSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTNDMLNGI----KQYKYTFFACLQLCKQRLIIQRCGCKSSALPEVPS------YNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERF-FKQERQAGQNHFMKTAYEYLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASDLIR------QNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGIS 545
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|P51168|SCNNB_HUMAN (Amiloride-sensitive sodium channel subunit beta OS=Homo sapiens OX=9606 GN=SCNN1B PE=1 SV=2) HSP 1 Score: 61.2326 bits (147), Expect = 1.885e-8 Identity = 77/356 (21.63%), Postives = 129/356 (36.24%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESE---TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
Y NC+ F + A F L+++L DI D P +T G L LH + +YP I EG+ + GT T I + M P+ C+ N + + + + YS +C + Q +I+ CNC YL +P+ R KY + D F + C S+ + ++ + CK C Y +IS A WP+++ S D + L +E+ + N+T + ++ + + F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 269 YGNCYIFNWGMTEKALPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYL--------------------YPLPRG-EKYCNNRD----FPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEA------------------------SEDWIFHV----------------LSQER------DQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII 545
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|O97742|SCNNB_RABIT (Amiloride-sensitive sodium channel subunit beta OS=Oryctolagus cuniculus OX=9986 GN=SCNN1B PE=2 SV=1) HSP 1 Score: 60.4622 bits (145), Expect = 3.731e-8 Identity = 87/398 (21.86%), Postives = 141/398 (35.43%), Query Frame = 1
Query: 670 DLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPL----KICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
+LG+S ++L+C GA + S Y NC+ F + A F L+++L DI D P +T G L LH + +YP I EG++ + GT T I + P+ C+ N + + + + YS +C Q ++I C C YL PL + C FP W ++ E ET R CK C Y +IS A WP+++ ++ ++ + + T++ +S+ V+KL N+ F E F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 238 ELGYSAERLILACLF---------GAEPCSYRNFTSIFYPDYGNCYVFNWGMTEKALPSANPGTEFGLKLIL------DIGQEDYVPFLAST--AGVRLMLHEQRSYPFIREEGVDAMSGTETSIGVLVDKLQRKGEPYSPCTVNGSDVPVQNLYGSYNTTYSIQACLHSCFQTQMIASCQCGHYLY----------PLPRGQEYCNSRDFP----------DWAPCYLALRMSEAERETCIR------MCKESCNDTQYKMTISMADWPSEASED-WIFHVLSQERDQSTNVTLSRKG-------------------VVKL--------------NIYFQE------------FNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFAEIII 546
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q95165|SCNNB_CANLF (Amiloride-sensitive sodium channel subunit beta OS=Canis lupus familiaris OX=9615 GN=SCNN1B PE=3 SV=2) HSP 1 Score: 59.3066 bits (142), Expect = 8.618e-8 Identity = 76/356 (21.35%), Postives = 132/356 (37.08%), Query Frame = 1
Query: 793 YHNCHTF-------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKN---IDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESE---TASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFI 1821
Y NC+ F + A F L+++L DI D P +T GA L LH + +YP I+ EG+ + GT T I P+ +C+ N + + + + YS +C + Q +I+ C+C YL +P+ R N +F + C S + ++ ++ CK C Y +IS A WP+++ ++ ++ + + T++ +S+ V+KL N+ F E F+ +EE A ++ LS GG W G + C++E E+ I
Sbjct: 270 YGNCYIFNWGMTEKALPSANPGAEFGLKLIL------DIGQEDYVPFLTST--AGARLMLHEQRSYPFIKDEGIYAMSGTETSIGVLVDRLERKGEPYSQCTVNGSDVPVRNLYSDYNTTYSIQACIRSCFQDHMIQNCSCAHYL--------------------YPLPRGERYCNN-----REFPDWAYCYSHLRMSVAQRETCINMCKESCNDTQYKMTISMADWPSEASED-WIFHVLSQERDQSTNITLSRKG-------------------VVKL--------------NIYFQE------------FNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEILI 546
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Match: sp|Q925H0|ASIC2_MOUSE (Acid-sensing ion channel 2 OS=Mus musculus OX=10090 GN=Asic2 PE=1 SV=1) HSP 1 Score: 57.7658 bits (138), Expect = 1.978e-7 Identity = 87/360 (24.17%), Postives = 146/360 (40.56%), Query Frame = 1
Query: 187 EKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRI-IKSSNPKQRLLWTFFVAVFFIACVTCVGLL-------VSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLT-SRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSIDP----NDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNC 1185
E P + + SS Q+ F T++L G+ I + +R+LW +A V +GLL VS Y +Y + + V QS FP++T+CNL SR L N++ A E + L L+ L P + + N Y PK + +GH +M+L C G C + +TV Y C+ F ++ LE++L DI+ + P+ T+ T G + +HS+ P I+ G + PG T + + + + PP G+C ++ +M + F F YS ++C+ + +++ CNC
Sbjct: 5 ESPSEGSLQPSSIQI-------FANTSTLHGIRHIFVYGPLTIRRVLWA-------VAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSR----LTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHY---KPKQFSMLEFLHRVGHDLKDMMLYCKF--------KGQECGH--QDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIML------DIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDF----FPVYSITACRIDCETRYIVENCNC 322
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A094ZK54 (FMRFamide-activated amiloride-sensitive sodium channel OS=Schistosoma haematobium OX=6185 GN=MS3_03260 PE=3 SV=1) HSP 1 Score: 431.024 bits (1107), Expect = 2.806e-139 Identity = 227/562 (40.39%), Postives = 348/562 (61.92%), Query Frame = 1
Query: 193 PLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQ-SKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNF-EDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCI-DYLQVPTELMWAKEPLKICKFLRFPVE-RNVTKYNISWDI------LEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFV-KYIEEKMKRMHTDLPVSKSSDNVI--EXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSL 1839
PL E S IK +FCETTSLRGVPRI+ + + K+R LW FV FFI C+TC+ ++SQY +DVIHQP+ +Y+Q RPFPS+T+CNLRP ++R I+ L K +L + + LK + S P++ + +T W+ +TY NLP +D N+LGH+ ++V C I+Y+ G + G ACEK G W T +++HNC+T+ +N TN ++E+V+YLDN E +C DCQ +A+QLTGA L LH +YP++ EG+NL+PGT+T+IRFT EWSMMEPPHG+CSKN +SF+N + +SE +C ++Q+++ C C+ +L +PT L+ + L+ C+ + P + + +N S + + + +C +T + + C+ C +TY SI++A+WP K++ T FV K+I+E ++ L + + I E ++++ L PY+ + L ++ L +A ++L N EQN L++ ++RPNFD+ VEEKAVVSLTS SQ GGLLSIW G+TF C+VEL E+ + + D++
Sbjct: 114 PLPNEYNSSLLTQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIISQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAGVLPVDMYFEMLKRFMTS-----VPMEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLTQHLPIPTHLL--GKDLRKCQAFKLPATYQMLDNFNESKQLYFNDEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVTKFIKEMEASGYSRLKSTNNETLTIFNERMEEIRTPLQPYEIISNLTKQGHLQEAIKMLMNTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIVELVELGLNVADAV 668
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A3Q0KJ87 (Putative amiloride-sensitive sodium channel OS=Schistosoma mansoni OX=6183 PE=3 SV=1) HSP 1 Score: 428.328 bits (1100), Expect = 1.670e-138 Identity = 229/565 (40.53%), Postives = 351/565 (62.12%), Query Frame = 1
Query: 193 PLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQ-SKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNF-EDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCI-DYLQVPTELMWAKEPLKICKFLRFPVE-RNVTKYNISWDI------LEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFV-KYIEEKMKRMHTDLPVSKSSDNVI-----EXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSL 1839
PL E S IK +FCETTSLRGVPRI+ + + K+R LW FV FFI C+TC+ +++QY +DVIHQP+ +Y+Q RPFPS+T+CNLRP ++R I+ L K +L + + LK + S P++ + +T W+ +TY NLP +D N+LGH+ ++V C I+Y+ G + G ACEK G W T +++HNC+T+ +N TN ++E+V+YLDN E +C DCQ +A+QLTGA L LH +YP++ EG+NL+PGT+T+IRFT EWSMMEPPHG+CSKN +SF+N + +SE +C ++Q+++ C C+ +L +PT L+ + L+ C+ + P + + +N S + + + +C +T + + C+ C +TY SI++A+WP K++ T FV K+I+E ++ L KS++N E ++++ K L PY+ + L +E +L +A ++L EQN L++ ++RPNFD+ VEEKAVVSLTS SQ GGLLSIW G+TF C+VEL E+ + + D++
Sbjct: 95 PLSNEYNPSLLTQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIINQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAEVLPVDMYFEMLKRFMIS-----VPVEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLTQHLPIPTHLL--GKDLRKCQAFKLPATYQMLDNFNESKQLYFNNEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVTKFIKEMELSGYSRL---KSTNNETLSIFNERMEEIRKPLQPYEIIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIVELVELGLNVADAV 649
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G4V8Q7 (Putative amiloride-sensitive sodium channel OS=Schistosoma mansoni OX=6183 GN=Smp_093210 PE=3 SV=1) HSP 1 Score: 422.935 bits (1086), Expect = 1.152e-136 Identity = 225/564 (39.89%), Postives = 344/564 (60.99%), Query Frame = 1
Query: 193 PLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQ-SKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNF-EDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCI-DYLQVPTELMWAKEPLKICKFLRFPVE-RNVTKYNISWDI------LEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVI-----EXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSL 1839
PL E S IK +FCETTSLRGVPRI+ + + K+R LW FV FFI C+TC+ +++QY +DVIHQP+ +Y+Q RPFPS+T+CNLRP ++R I+ L K +L + + LK + S P++ + +T W+ +TY NLP +D N+LGH+ ++V C I+Y+ G + G ACEK G W T +++HNC+T+ +N TN ++E+V+YLDN E +C DCQ +A+QLTGA L LH +YP++ EG+NL+PGT+T+IRFT EWSMMEPPHG+CSKN +SF+N + +SE +C ++Q+++ C C+ +L +PT L+ + L+ C+ + P + + +N S + + + +C +T + + C+ C +TY SI++A+WP K++ T F V+KS++N E ++++ K L PY+ + L +E +L +A ++L EQN L++ ++RPNFD+ VEEKAVVSLTS SQ GGLLSIW G+TF C+VEL E+ + + D++
Sbjct: 95 PLSNEYNPSLLTQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVISFFIGCITCLTFIINQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAEVLPVDMYFEMLKRFMIS-----VPVEYRRYLTMLWDFSTYLANLPDLVDANNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNKTNTALNMELVVYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCSKNTPQFISFNNVNYTFSEEACHAHMVQEKVASNCQCLTQHLPIPTHLL--GKDLRKCQAFKLPATYQMLDNFNESKQLYFNNEAVSTYARFAECAEKTGTAMDSYQIGCRPACVRYTYKPSITAAQWPTKTFLTWF----------------VTKSTNNETLSIFNERMEEIRKPLQPYEIIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIVELVELGLNVADAV 635
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: G7YD97 (FMRFamide-activated amiloride-sensitive sodium channel OS=Clonorchis sinensis OX=79923 GN=CLF_105251 PE=3 SV=1) HSP 1 Score: 421.394 bits (1082), Expect = 4.132e-136 Identity = 223/552 (40.40%), Postives = 341/552 (61.78%), Query Frame = 1
Query: 232 IKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREF---IQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNF-EDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCI-DYLQVPTELMWAKEPLKICKFLRFPV------ERNVTKYNISWD-ILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFV-KYIEEKMKRMHTDLPVSKSSDN--VIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLF 1842
I+ +FCETTSLRGVPRI+ + + K+RLLW FV FF+ C+TC+ L++QY AYDVIHQP+ +Y+ R FPS+T+CNLRP +++ I+ L ++ + IQR+ Q+R P + +T W ++ Y NLP+++D + LGHS+H++V C IVY+ G + G CE G W T ++HNC+T+ + + TN+ ++EMV+YLDN E +C DCQ A+QLTGA L LH +YP++ EG+NL+PGT+T+IRF+ EWSMMEPPHG+CS + +S++F++ + YSE +C + + Q ++++ CNC+ L +PTEL+ K L C+ RFP N+TK + D + + ++C E ++ + C+ C +TY SI++A+WP K++ T FV K+++ P ++ V E L +L + L PY+ ++ L K +A + L + E+N LA+ ++RPNFD+ VEEKAVVSLTS SQ GGLLSIW G+TF C+VEL E+ + + D++
Sbjct: 81 IRGQFKQFCETTSLRGVPRIVSTKDTKRRLLWLIFVLAFFVGCITCLIFLINQYLAYDVIHQPKKLYDLPRSFPSVTICNLRPFSTKDIRKLKAAGVVPVDMYFDNIQRMIPQVR-------PENRRYMTMLWTMSAYLYNLPETLDESALGHSKHDIVKRCYIVYKRGTMNRGTDCESSGYWTKTRDPVFHNCYTYTIFQNLTNQVLNMEMVVYLDNLVEQTDCFDCQERVRASQLTGARLLLHPRASYPRVAEEGINLMPGTMTDIRFSVYEWSMMEPPHGRCSTSTPVSINFNHVNYSYSEEACHKHVRQLKVVQTCNCLTQSLPIPTELLDRK--LNRCEAFRFPATIDLSDNFNMTKQSYFNDESIARLVQSSRCAEEILTKLDSSATGCRPACVRYTYRPSITAAQWPTKTFLTWFVTKFLKRITTATIRGRPHMTEAEQVRVQESLDELQELLSPYEEILNLTRAGKQAEAIQKLMSTEIFERNFLAIVISRPNFDVERVEEKAVVSLTSLFSQIGGLLSIWVGLTFVCIVELVELGLNVADTVL 623
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Match: A0A4Z2DTC2 (FMRFamide-activated amiloride-sensitive sodium channel OS=Schistosoma japonicum OX=6182 GN=EWB00_006004 PE=3 SV=1) HSP 1 Score: 422.55 bits (1085), Expect = 5.403e-136 Identity = 230/611 (37.64%), Postives = 362/611 (59.25%), Query Frame = 1
Query: 94 NQMYTSFHFQGYPENLNSPPLIKCKTCCQPAEKPLDKEIA--LSSKQV--------------IKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQ-SKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNF-EDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCI-DYLQVPTELMWAKEPLKICKFLRFPVERNV-------TKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFV-KYIEEKMKRMHTDLPVSKSSDNVI--EXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSL 1839
NQ + H G L+S +K K Q + LDK + LS+ + IK +FCETTSLRGVPRI+ + + K+R LW FV FFI C+ C+ ++SQY +DVIHQP+ +Y+Q RPFPS+T+CNLRP ++R I+ L K +L + + LK + + P++ + +T W+ +TY NLP +D ++LGH+ ++V C I+Y+ G + G ACEK G W T +++HNC+T+ +N TN ++E+VLYLDN E +C DCQ +A+QLTGA L LH +YP++ EG+NL+PGT+T+IRFT EWSMMEPPHG+C+K+ +SF+N + +SE +C ++Q+++ C C+ +L +PT L+ L+ C+ + P + + + + + ++ +C +T + C+ C +TY SI++A+WP K++ T FV K+I+E ++ + ++ + I E ++++ L PY+ + L +E +L +A ++L EQN L++ ++RPNFD+ VEEKAVVSLTS SQ GGLLSIW G+TF C+VEL E+ + + D++
Sbjct: 65 NQPMKTNHKNGKAPKLDSNNGVKNKHLDQFSNNELDKTLTDPLSATSLSPLPNEYTTPLLTQIKRQFRQFCETTSLRGVPRIVSTKDSKRRFLWLIFVIAFFIGCIICLTFIISQYLEFDVIHQPKKLYDQPRPFPSVTLCNLRPFSTRDIRKLKKAGVLPVDMYFEMLKRFMVN-----VPLEYRRYLTMLWDFSTYLANLPDLVDESNLGHTLEDIVKRCFILYKTGSVTRGTACEKSGYWTKTQDRVFHNCYTYTINPNRTNTALNMELVLYLDNLIEQTDCFDCQERVMASQLTGARLLLHPGASYPRVAEEGVNLMPGTMTDIRFTVYEWSMMEPPHGRCNKHTPEFISFNNVNYTFSEEACHAHMVQEKVASNCQCLTQHLPIPTHLLGKN--LRKCQAFKLPATYQMLNNLNESKQLYFNEEAVSNYSQFAECAEKTGTAIDTYQIGCRPACVRYTYKPSITAAQWPTKTFLTWFVNKFIKEMETSGYSRINLTNNETLTIFNERMEEIRAPLQPYELIANLTKEGRLQEAIKMLMQTQIFEQNFLSIIISRPNFDLERVEEKAVVSLTSLFSQIGGLLSIWIGLTFVCIVELVELGLNVADAV 668
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544]) HSP 1 Score: 56.9954 bits (136), Expect = 4.016e-8 Identity = 113/565 (20.00%), Postives = 192/565 (33.98%), Query Frame = 1
Query: 199 DKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPK-QRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIF 1830
D E ++ S + S+ F +++L G+ I + +RLLWT + VS Y + I + V + FP++T CNL I KN++ E + L +Y+ + V + F+N PK + D GH + M+L C G C ST+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + E K C L F VE++ N C++PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +F
Sbjct: 7 DSEDSIES--IRPSNLQAFANSSTLHGMSHIFAYGHMTFRRLLWTLSFLGSLGLLLVVCMDRVSYYLQFPHITKLDEVAAPNLTFPAVTFCNLNEFRFSKIT---KNDLYHVGELLALLN---ENYQIANPHLAEPEVLAALKEKGNFVNFKPKQFNMTDFYNRTGHDINEMLLQCTF--------RGEDCYPFN--FSTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCK-----STPIDSEFFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPEQYKDCADPALDFLVEKD-----------------------------NDYCVCQTPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 461
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1c (acid-sensing ion channel 1C-like [Source:NCBI gene;Acc:103034544]) HSP 1 Score: 56.9954 bits (136), Expect = 4.373e-8 Identity = 113/565 (20.00%), Postives = 192/565 (33.98%), Query Frame = 1
Query: 199 DKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPK-QRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIF 1830
D E ++ S + S+ F +++L G+ I + +RLLWT + VS Y + I + V + FP++T CNL I KN++ E + L +Y+ + V + F+N PK + D GH + M+L C G C ST+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + E K C L F VE++ N C++PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +F
Sbjct: 7 DSEDSIES--IRPSNLQAFANSSTLHGMSHIFAYGHMTFRRLLWTLSFLGSLGLLLVVCMDRVSYYLQFPHITKLDEVAAPNLTFPAVTFCNLNEFRFSKIT---KNDLYHVGELLALLN---ENYQIANPHLAEPEVLAALKEKGNFVNFKPKQFNMTDFYNRTGHDINEMLLQCTF--------RGEDCYPFN--FSTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGDTDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCK-----STPIDSEFFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPEQYKDCADPALDFLVEKD-----------------------------NDYCVCQTPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEVAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 461
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Match: asic1a (acid-sensing ion channel 1A-like [Source:NCBI gene;Acc:103034215]) HSP 1 Score: 55.0694 bits (131), Expect = 1.481e-7 Identity = 100/436 (22.94%), Postives = 165/436 (37.84%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPKQRL-LWTFFV--AVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDP----NDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAY-------TNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQF-KYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPL-KICKF--LRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKR 1491
F ++L G+ I R LW F +V F+ CV CV ++ Y Y + + V + FP++T+CNL + +N++ A E + L ++ Y+ + + + V S F N P+ + N GH +M+LSC G+ C + V Y C+TF E LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C + D++ F YS S+C+ + L++ CNC + +P + + L K C L F VER+ N C++PC Y +S K P+K+ KY+ +K +
Sbjct: 25 FAHMSTLHGIAHIFTYDRITLRCCLWLLFFLSSVAFLVCV-CVDRVLF-YLEYPHVTKVDEVVAPAMVFPAVTLCNLNAFRFGRVT---RNDLYHAGELLALLNSR---YEIRDVHLIEESVLESLKTKADFQNFKPRPFNMMEFYNRTGHDIRDMLLSCQF--------RGSPCRP--EDFKVVFTRYGKCYTFNSGETGPLLISMKGGMGSGLEIML------DIQQDEYLPVWGETDETSFEAGIKVQVHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPPPWGNCKTG-----TLDSDFFTAYSISACRIDCETRYLVENCNC-RMVHMPGDAPYCTPELYKECAHPALDFLVERD-----------------------------NDYCLCETPCNTTRYSKELSFVKIPSKAS----AKYLAKKFSK 397
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO42137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2F2]) HSP 1 Score: 85.5001 bits (210), Expect = 1.749e-17 Identity = 121/581 (20.83%), Postives = 216/581 (37.18%), Query Frame = 1
Query: 250 KFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKT---QLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDL---------------GHSRHNMVLSCAIVYREGIYS---SGAACEKVGK------WVSTVSKIYHNCHTF------------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGK-CSKNIDMSMS--FDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKEKPLKH 1866
+F + T+ G R+ ++ K RL W F + V + LV+QY + + + + + Q FP +T+CN+ N+L A +L+T Q+ + K +P S S + N + +DP DL H + ++S A + + S +G C W T + + NC+ F + + + + L + L L+ E +E T++ G + + +G P +G+ ++PG T I+ T + ++P + C + +MS F YS +CK L I++C C +Y P K + +C L + + N ++D E + C+ E C C+ ++D ++SSA+WPA+S+ KY R+ + S S K + + +N+ V V D LV+E + S LS GG + +W GI+ EL E+ +I ++ + K + H
Sbjct: 17 QFLQETTAHGFGRLGATAGSKWRLYWVMFCLAAYCVFVWQLVGLVNQYNSKPIKTRTQLKHAQKLDFPVVTICNM--------------NVLRASRLPPKLRTKFDQIINNTNKTSPRNS-----SNSRNAF-------VDPQDLSFEETKKFEILHAVTAHDDYRELVSAAHQLEDILLSCNFNGVNCRNSKDPTIPTYWTQTWNDNFGNCYMFNSVKTHNGEKVDLYSSSVPGESNGLTLQLNLEQNEYLEG--------ITEVAGMKVTISDQGVLPFPGQQGIRIMPGQSTGIQMTKLQTRRIDPFKNRSCESSNEMSDKNLFFGYNMTYSIMACKYSCLNARKIERCGCTNY-NTPE---MQKRNIPLCNRLNSTI---IDCLNKAYDTFEDGS----CDRE-----------CPPSCSEVSFDLTVSSARWPARSFEV--TKYAYFLRVRVLNKIASSSS---------------------------KYFVNS-----------ENIAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVILANMSNRSKKIVH 501
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO39413 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA77]) HSP 1 Score: 50.447 bits (119), Expect = 1.487e-6 Identity = 51/269 (18.96%), Postives = 106/269 (39.41%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQ----IATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEI 1023
F T+L G+ + + ++++W + + + +G + + +Y++ V +S PFP++T+CN L I L + + Y +L ++++ + N+ + +N+ + + GH MV C V + C+ V T K C+TF ++N +++ +SL + L D +P + + TG + +H + P IE + ++ PG T+I
Sbjct: 52 FASYTTLHGLHFLFQPIPRARKIIWGIMLVIATVGLSIQIGNGLVKVYSYNIFTAKTFVRPESLPFPAITICNQNMLRKTAI-----------------LGSAGQRYLDQLDELRARFIGEDMNVTSERINMDAIVQKS--GHQLEKMVYECRFVRDK--------CDNKSIKVFTSEK-RGLCYTFNSGVNGTPLLNVSHSGSEYSLSLRL-----------DAEPTEYYGPYSYDGTGFKIAVHDQKVLPDIEEDAYDISPGFYTKI 281
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Match: EDO37667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF92]) HSP 1 Score: 49.2914 bits (116), Expect = 3.770e-6 Identity = 53/243 (21.81%), Postives = 86/243 (35.39%), Query Frame = 1
Query: 1123 YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLI-KANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVK 1848
YS ++C L + + C C++Y + P + +C L V R + K + N+ C ++C+ PC + SISSA+WP Y F+ +LKE+K + AN R + +Q+ + ++EE L +F+S GG L +W GI+ EL E+ I+I L K
Sbjct: 57 YSRTTCMDSCLAHKQVDMCGCLEY-RFPN-----IDNRTVCDILDIDVIRCLNKVQSLYQ-----DNKLGCS-----------EKCRPPCNEEVFKLSISSARWPTDDYEAHFLD----------------------------------------ELKEDKGFVLPANADARAY------FVKLQIFYEELNHEVIEEYRSYELVNFVSDIGGQLGLWIGISALTASELVELLIVIALHLLRK 231
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000021936.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951]) HSP 1 Score: 52.373 bits (124), Expect = 1.259e-6 Identity = 108/573 (18.85%), Postives = 200/573 (34.90%), Query Frame = 1
Query: 217 SSKQVIKSHCIKFCETTSLRGVPRIIKSSNPK-QRLLWTFFVAVFFIACVTCVGLL-------VSQYRAYDVIHQPRTVYNQSRPFPSLTVCN-----LRPLTSRGI-------QILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIF 1830
S + +K ++F T + G+ I + K Q+++W +A + C+ L + +Y V+ + V+ + FP++T+CN + LT + ++ N+ L R + LK R +L ++ +++NT + + LGH +M+L C G C + ST+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + + K C L F VE++ N C++PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +F
Sbjct: 27 SLQNTLKETTVEFIRRTKVHGLKFIFSPNKSKFQQIIW-------ILAFLLCISLFCTWSWNRIFYLMSYPVVTKIYMVWAHNMSFPAVTLCNKNVFRVSALTKDDLYHSGYWMDLMNPNHTLINRS-LSILKESHRPGLLRLLDFRNYAPPPDYSVNTTEMM-------SRLGHQLEDMLLECKF--------RGETC--TFRNFSTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCK-----STPIDSEFFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPDQYKDCADPALDFLVEKD-----------------------------NNYCVCETPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 482
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000035361.1 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951]) HSP 1 Score: 51.9878 bits (123), Expect = 1.691e-6 Identity = 108/573 (18.85%), Postives = 200/573 (34.90%), Query Frame = 1
Query: 217 SSKQVIKSHCIKFCETTSLRGVPRIIKSSNPK-QRLLWTFFVAVFFIACVTCVGLL-------VSQYRAYDVIHQPRTVYNQSRPFPSLTVCN-----LRPLTSRGI-------QILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIF 1830
S + +K ++F T + G+ I + K Q+++W +A + C+ L + +Y V+ + V+ + FP++T+CN + LT + ++ N+ L R + LK R +L ++ +++NT + + LGH +M+L C G C + ST+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + + K C L F VE++ N C++PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +F
Sbjct: 27 SLQNTLKETTVEFIRRTKVHGLKFIFSPNKSKFQQIIW-------ILAFLLCISLFCTWSWNRIFYLMSYPVVTKIYMVWAHNMSFPAVTLCNKNVFRVSALTKDDLYHSGYWMDLMNPNHTLINRS-LSILKESHRPGLLRLLDFRNYAPPPDYSVNTTEMM-------SRLGHQLEDMLLECKF--------RGETC--TFRNFSTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCK-----STPIDSEFFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPDQYKDCADPALDFLVEKD-----------------------------NNYCVCETPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 482
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: ENSORLT00000021925.2 (acid-sensing ion channel 1C [Source:NCBI gene;Acc:101174951]) HSP 1 Score: 50.0618 bits (118), Expect = 5.843e-6 Identity = 104/544 (19.12%), Postives = 178/544 (32.72%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNPK-QRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLT-PIQSKLVTTSWNLNTYFLNLPKSID-PNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTF--------IVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFK-YSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIF 1830
F ++L G+ I + +R LWT + V Y Y + + V + FP++T CNL I +N++ E + L + L P + N N + L D N GH M+L C G C + +T+ Y C+TF ++ LE++L DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S D+E F YS ++C+ + L++ CNC T + + K C L F VE++ N C++PC Y +S K P+K+ KY+ +K + +I N+L + + + +E+K + L GG + ++ G + ++E+F+ +F
Sbjct: 20 FANISTLHGMSHIFAYGHMTFRRFLWTLSFLGSLSLLMLVCMDRVVYYLEYPHVTKLDEVAATNLTFPAVTFCNLNEFRFSKIT---RNDLYHVGELLALLNNDHQIANPHLAEPEVLAALKDKANFNNFKPKLFNMTDFYNRTGHDISEMLLQCTF--------RGEDCYAMN--FTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIML------DIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCK-----STPIDSEFFSTYSITACRIDCETRYLLENCNCRMVHMPGTSTVCTPDQYKDCADPALDFLVEKD-----------------------------NNYCVCETPCNMTRYGKELSMVKIPSKAS----AKYLAKKFNKTE------------------------------------------------QYIGDNILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVF 458
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Match: asic1a (acid-sensing ion channel 1 [Source:NCBI gene;Acc:101159102]) HSP 1 Score: 49.6766 bits (117), Expect = 7.886e-6 Identity = 95/431 (22.04%), Postives = 163/431 (37.82%), Query Frame = 1
Query: 253 FCETTSLRGVPRIIKSSNP-KQRLLWTF-FVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNL-PKSIDPNDL----GHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNR----TFSLEMVLYLDNFEDIECPDCQPLQIATQLT----GAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMW-AKEPLKICK--FLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKR 1491
F +++L G+ I +R LW F+ + CV + Y Y + + V FP++T CNL + +N++ A E + L + Y+ + + + V S + F N P+ + + GH +M+LSC + G C + G + ++ Y C+TF N R T M L+ DI+ + P+ T T G + +HS+ P I+ G + PG T + + + PP G C S FD+ YS ++C+ + L+ CNC + +P + + + E K C L F V+R+ N C++PC Y+ +S K P+K+ KY+ +K +
Sbjct: 21 FAHSSTLHGIAHIFTYERLCIKRCLWLLVFLCSLTLLLYVCVDR-IHYYLEYPHVTRLDEVATPIMTFPAITFCNLNAFRFSRVT---RNDLYHAGELLALLNHR---YEIRDVHLVEESVLESLKVKADFHNFKPRPFNMREFYDRTGHDIKDMLLSC--------HFHGTEC-RPGDFKVVFTR-YGKCYTF--NAGGDGRPPLITTKGGMGNGLELMLDIQQDEYLPVWGDTDETSFEAGVKVQIHSQDEPPSIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGDCKVTPMDSDFFDS----YSITACRVDCETRYLVDNCNC-RMVYMPGDAPYCSPELYKECADPALDFLVQRD-----------------------------NDFCVCETPCNMTRYNKELSFVKIPSKAS----AKYLAKKYNK 394
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000072389.1 (SMESG000072389.1) HSP 1 Score: 1177.93 bits (3046), Expect = 0.000e+0 Identity = 607/607 (100.00%), Postives = 607/607 (100.00%), Query Frame = 1
Query: 58 MIYENSDKVSFNNQMYTSFHFQGYPENLNSPPLIKCKTCCQPAEKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKEKPLKHSEEC 1878
MIYENSDKVSFNNQMYTSFHFQGYPENLNSPPLIKCKTCCQPAEKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCKQKLLQQELIKQCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEPLKDLYKKLLPYKRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKEKPLKHSEEC
Sbjct: 1 MIYENSDKVSFNNQMYTSFHFQGYPENLNSPPLIKCKTCCQPAEKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCKQKLLQQELIKQCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEPLKDLYKKLLPYKRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKEKPLKHSEEC 607
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000081650.1 (SMESG000081650.1) HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0 Identity = 282/546 (51.65%), Postives = 390/546 (71.43%), Query Frame = 1
Query: 229 VIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVK----YIEEKMKRMHTDLPVSKSS-DNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKE 1851
I H FCETTSLRGVPRI K+ +PK+R LW FFV FF+AC+TC+ LL+ QYR YDVIHQP+TVYN+ PFPSL+ CNLRPL+S I+ L N + + E++++LK + +K + KL+T SWN+N+YFLNLP S PNDLGH R MV+ C ++Y++GIY+SG C+K G WVST++ IY NCHTFIVN+ +TN+TFS+E+VLYLD+ ++I C DC ++I +QLTG LNLHS GTYP+I +G+NL+PGTLTEI+F PR+W+MMEPPHGKCSK + +SF+ +F+YSE +CK+K+LQ+EL K C+C+D+ QVP +L + KIC++L N T + + + N+T C +T+S N ++C SPCT+FTYDT+ISSA+WP KS+HT F+K YI+++M+ + ++S+ +IE LK + K+++E+ + +LL +L F+ N L++QV R NFDI LVEEKA VSLT+FLSQTGG+ SIWSGITFFC+VE+ E+FILIF+ +F K+
Sbjct: 57 AISKHWKVFCETTSLRGVPRIAKTRDPKRRFLWIFFVTAFFLACITCIVLLIMQYRQYDVIHQPKTVYNKPTPFPSLSFCNLRPLSSHSIKTLKNNGLNSVSEYLKQLKQSMEDLRKSSNITERKLLTMSWNINSYFLNLPNSTQPNDLGHDRLEMVMYCLLIYKQGIYNSGIVCDKAGHWVSTLNSIYINCHTFIVNKKFTNKTFSMEVVLYLDHADEIYCNDCNEMKIYSQLTGVRLNLHSSGTYPEIIEKGINLMPGTLTEIKFIPRQWNMMEPPHGKCSKQVSKKISFNKVEFQYSEEACKRKVLQEELAKNCDCVDFNQVPDDLNNYLQHKKICQYLPATPFSNATLSSFNHSQTADYLNKTHCNLQTSSEI-NYQNKCNSPCTFFTYDTTISSAEWPTKSFHTSFLKSLRDYIQKRMRNFYNITESTRSAWTTIIEELKPYLSL------IEKIEKEENVTLNKKLLNDLKFVSNNFLSIQVGRTNFDIILVEEKASVSLTNFLSQTGGIFSIWSGITFFCIVEILELFILIFEEIFSKK 595
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000013147.1 (SMESG000013147.1) HSP 1 Score: 432.565 bits (1111), Expect = 1.868e-143 Identity = 221/546 (40.48%), Postives = 330/546 (60.44%), Query Frame = 1
Query: 217 SSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQL---RSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSD-NVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLF 1842
S +I H KFCETTSLRGVP+I+ S + R+LW FV VFFIAC+TC LL+ QY AYDVIHQP+T YN FPS+T CNLRP +SR +++L ++NI + +F+ + S LT +L+T++ L + +NLP SI +GHS+++M++ C+I Y G S CE GKW+ T ++++ NC+T+ ++E Y +++++L++D+ + ECPDC A+Q+TG +LH+ TYP + EG NL PGT T+ F ++W+MM+PP+GKCSK + +F+ F YS C++ +Q L C CI Y +P + IC F + V +NV+KY + + ++ F NRTKC+ + R N C +PC Y+T+D +SS +P KS+H F K I++ + R + SK D N ++ + +K R +K + +A +LL+N IE+N L +Q+ R +F I VEEK V+S+TSFLSQTGG+ SIWSGITFFC+VE E+ + I++SLF
Sbjct: 139 SKTAIILFHFKKFCETTSLRGVPKIVHSQKKQFRMLWVIFVLVFFIACMTCTILLIKQYLAYDVIHQPKTSYNDPSNFPSVTFCNLRPFSSRTVELLKRSNIKSLVDFLHGFGRSVVMNSSIMLNLTSEDKQLLTSTLFLELFLMNLPLSISKESIGHSQNSMIIDCSIQYANGSEISSTKCELGGKWILTKNELFLNCYTYTMDEKYLQTATAVDLILHVDDRLEFECPDCNQFFTASQMTGIRFSLHTAHTYPDVILEGQNLSPGTFTDAVFYTKQWNMMQPPYGKCSKTLVEKYAFEEGDFLYSLKGCQKYTIQNLLYDNCGCIKYTNIPKRFAHLNKSQDICNFFEYSVFKNVSKYKLDLNNVKFFLNRTKCKKIISHRFLNDFSTCTNPCQYYTFDVKVSSGIYPTKSFHLYFTKNIQKILIRKIRN--SSKIEDMNELKSILHKFKIYDEISRKIK---NGSIAEAEKLLKNTDVIEKNFLTIQINRQDFSIIKVEEKEVISITSFLSQTGGMFSIWSGITFFCLVEFIELMMNIYNSLF 679
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000013147.1 (SMESG000013147.1) HSP 1 Score: 432.18 bits (1110), Expect = 2.492e-143 Identity = 221/546 (40.48%), Postives = 330/546 (60.44%), Query Frame = 1
Query: 217 SSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQL---RSYKKKLTPIQSKLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLDNFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDILEKFTNRTKCESETASRPHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSD-NVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLF 1842
S +I H KFCETTSLRGVP+I+ S + R+LW FV VFFIAC+TC LL+ QY AYDVIHQP+T YN FPS+T CNLRP +SR +++L ++NI + +F+ + S LT +L+T++ L + +NLP SI +GHS+++M++ C+I Y G S CE GKW+ T ++++ NC+T+ ++E Y +++++L++D+ + ECPDC A+Q+TG +LH+ TYP + EG NL PGT T+ F ++W+MM+PP+GKCSK + +F+ F YS C++ +Q L C CI Y +P + IC F + V +NV+KY + + ++ F NRTKC+ + R N C +PC Y+T+D +SS +P KS+H F K I++ + R + SK D N ++ + +K R +K + +A +LL+N IE+N L +Q+ R +F I VEEK V+S+TSFLSQTGG+ SIWSGITFFC+VE E+ + I++SLF
Sbjct: 136 SKTAIILFHFKKFCETTSLRGVPKIVHSQKKQFRMLWVIFVLVFFIACMTCTILLIKQYLAYDVIHQPKTSYNDPSNFPSVTFCNLRPFSSRTVELLKRSNIKSLVDFLHGFGRSVVMNSSIMLNLTSEDKQLLTSTLFLELFLMNLPLSISKESIGHSQNSMIIDCSIQYANGSEISSTKCELGGKWILTKNELFLNCYTYTMDEKYLQTATAVDLILHVDDRLEFECPDCNQFFTASQMTGIRFSLHTAHTYPDVILEGQNLSPGTFTDAVFYTKQWNMMQPPYGKCSKTLVEKYAFEEGDFLYSLKGCQKYTIQNLLYDNCGCIKYTNIPKRFAHLNKSQDICNFFEYSVFKNVSKYKLDLNNVKFFLNRTKCKKIISHRFLNDFSTCTNPCQYYTFDVKVSSGIYPTKSFHLYFTKNIQKILIRKIRN--SSKIEDMNELKSILHKFKIYDEISRKIK---NGSIAEAEKLLKNTDVIEKNFLTIQINRQDFSIIKVEEKEVISITSFLSQTGGMFSIWSGITFFCLVEFIELMMNIYNSLF 676
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Match: SMESG000044381.1 (SMESG000044381.1) HSP 1 Score: 287.73 bits (735), Expect = 1.302e-88 Identity = 185/567 (32.63%), Postives = 288/567 (50.79%), Query Frame = 1
Query: 178 QPAEKPLDKEIALSSKQVIKSHCIKFCETTSLRGVPRIIKSSNPKQRLLWTFFVAVFFIACVTCVGLLVSQYRAYDVIHQPRTVYNQSRPFPSLTVCNLRPLTSRGIQILLKNNILTAREFIQRLKTQLRSYKKKLTPIQS-KLVTTSWNLNTYFLNLPKSIDPNDLGHSRHNMVLSCAIVYREGIYSSGAACEKVGKWVSTVSKIYHNCHTFIVNEAYTNRTFSLEMVLYLD-NFEDIECPDCQPLQIATQLTGAHLNLHSEGTYPQIETEGLNLLPGTLTEIRFTPREWSMMEPPHGKCSKNIDMSMSFDNEQFKYSESSCXXXXXXXXXXXXCNCIDYLQVPTELMWAKEPLKICKFLRFPVERNVTKYNISWDI-----LEKFTNRTKCESETASR-PHNILDQCKSPCTYFTYDTSISSAKWPAKSYHTMFVKYIEEKMKRMHTDLPVSKSSDNVIEXXXXXXXXXXXXXRVMKLKEEKKLIKANELLRNLTFIEQNLLAVQVTRPNFDITLVEEKAVVSLTSFLSQTGGLLSIWSGITFFCVVELFEMFILIFDSLFVKEK 1854
+P+E LD EI ++ K + K ++FCE T+LRGVPRI+KS R LW F + FI + C+ L QY Y+VIH PR + + PFPSLTVCN RP+ ++I+ K NI REF + Y K ++ + ++ N+ Y ++P N+LGH ++++ C + Y G C +GKW + Y NC+++ + E Y+ T ++E+ YLD D C DC + +QL+GA + +H T+P + +NL PGTLTEI+ EPP+G+CS +M N+ + YSE +CK +Q ++ KQC C + ++ P + L C L +E + + S D+ L+ + C+S +S+ +I+ C PC ++Y++ S++ WP K++ ++K +R+ + D E L + K+ +L +EQNLLAV + RPN+++ LVEEK V+SLTSFLSQ GGL SIW G+T +VE+ EM + F L K
Sbjct: 2 EPSE--LDSEIIINFKTISKEEFLRFCENTTLRGVPRIVKSRKSHIRHLWLTFFILLFIGFMVCIIFLCYQYLEYNVIHPPRILSDNKAPFPSLTVCNYRPMKRNILEIMKKRNIKDPREFAHSINKYAIKYYYKKNLGKNYQRASSIMNMGAYLESVPNRT-FNELGHDEQDLIIYCQVTYMNGSSPHYKVCSDIGKWRVIIHAQYINCYSYNLYENYSRNTNTMELYFYLDQGIPDSMCLDCFSSDVKSQLSGALVLIHRRLTFPNFNHDIINLQPGTLTEIKLKIFNNVHKEPPYGRCSYKSPKTMKIYNDLYSYSEHACKLLTIQHDINKQCGC-NAIEYPIDNF----NLSFCSNLPRFIEGKLCHDDQS-DMKCKHQLDAVVKKIICKSNVSSQYQKDIVKSCSLPCDIYSYESDRSTSSWPTKTWQMPWIK--SNAARRLRKKPELKGYIDAYREYL------------------NGSVNKSFRILNQQNILEQNLLAVMINRPNYNVHLVEEKEVLSLTSFLSQAGGLCSIWIGLTMISIVEVIEMLLNCFSQLKTARK 539 The following BLAST results are available for this feature:
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 4
BLAST of FMRFamide-activated amiloride-sensitive sodium channel vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021102 ID=SMED30021102|Name=FMRFamide-activated amiloride-sensitive sodium channel|organism=Schmidtea mediterranea sexual|type=transcript|length=1883bpback to top protein sequence of SMED30021102-orf-1 >SMED30021102-orf-1 ID=SMED30021102-orf-1|Name=SMED30021102-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=608bp MIYENSDKVSFNNQMYTSFHFQGYPENLNSPPLIKCKTCCQPAEKPLDKEback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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