TIR domain-containing protein

Overview
NameTIR domain-containing protein
Smed IDSMED30021086
Length (bp)2069
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TIR domain-containing protein (SMED30021086) t-SNE clustered cells

Violin plots show distribution of expression levels for TIR domain-containing protein (SMED30021086) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TIR domain-containing protein (SMED30021086) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TIR domain-containing protein (SMED30021086) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021086

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 6

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
parapharyngeal regionSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30021086h1SMcG0014548 dd_Smed_v4_13404_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A210PZ21 (Vacuolar protein 8 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT23907 PE=4 SV=1)

HSP 1 Score: 154.836 bits (390), Expect = 1.706e-35
Identity = 129/489 (26.38%), Postives = 220/489 (44.99%), Query Frame = 2 
Query:  278 DLYLSLTKLFNEIKENHTSKEVGNNLPTSFAVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGS-LSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNN----PQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQL 1729
            D+ + + K   E ++     E+   L  +F +L +     ++   E  D +      +       K++  P + G  + E ++++   S  +++  +    + NI+++  L   + L  F   P +  ++     +A I +EK S     D+  +  I   L+ ++K          P  EL + V R+++ND NKR +VE GILP L  L E+   + +  ++  +  LS+D+ N+ ++       + D +     KP +   I   N PD  + K  +     G + T              L+QS N     + Y S Q                      PSP      +     ++ H+MISY   N     K+ D L+A  FK+W+D  DM  +   ++AMA+AVEN+  V++C S  YK+S++CRAEA+YA   KK +IP+ ++  Y PDGWLG       + +F GKYS E  +  LVK+L
Sbjct:  228 DMVVYILKHGYEAEDGTMDAEMFKPLSNTFGLLTNF----TDNKIERADIVADHPEFLMCLAENFKKWMNPYLAGDQIREDQIRVAISSPLSIFHNIAM-QDRNINRMRSLGFVDLLTPFVSSPKEKTRLSAVATLADIVDEKQSEIIRTDVGVMKFIKNSLARAMKEKSRRIFGWSP-QELARTVRRIARNDANKRALVEQGILPPLVKLAESEDMEEQREAVGAMWTLSFDKENQKDM-------ILDTE----CKPVDTF-IRLKNSPDKEVRKTCN-----GALWTM----------RENLAQSENYKDIRERYTSPQ----------------------PSPAHVATERRQEVKSEGHIMISYQWANQAILKKIRDNLRANGFKVWMDIDDMEGS--TLDAMARAVENADVVLVCYSQKYKDSDNCRAEAEYAFQKKKKVIPLKMELNYIPDGWLGFICGAKLFFDFGGKYSFESRVEGLVKEL 659
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: C3YBW8 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_130981 PE=3 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 1.947e-35
Identity = 118/438 (26.94%), Postives = 217/438 (49.54%), Query Frame = 2 
Query:  647 NQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGE 1960
            ++++K    + +AYI  E+D+   + D S I  I+ V  ++V + E    Q +  +E+   + +L++ND NK  +V+ G LP+L  L+ET   + +    + +  L++ + NK +I  +  ++++ L+ LK  K +E       N     LDK A  +            +   + S   L + + P I  S Q    + L  +        +++  S   D    + P     H+MISY  ++    +K+ D L++  +++W+D   M    + ++AMA+AVENS  V+IC+S  YK S +CR EA+Y    +K ++P++++ KY+PDGWLG  +    Y +FS ++  E+S+G L+K+L Q     Q  +  +  +                  ++ DW  ++V NW  +  ++K  +    TG +L FL+S+ GE
Sbjct:  245 DEELKTVTVMTLAYIVGEEDNDLIMADDSVISFIMTVFEEAVDS-ELMRSQGFSAMEMAMGISQLAQNDDNKVMIVKKGALPLLVQLMETGDEEEQEQGANAVWQLAFHDDNKDKIRAE-PRLMYQLKRLKDSKNQET--AKAANGALWVLDKQAREEK------AKELSEKSEESSREDLQEGSGPHIMISYQWDHQKTL--VKEKAKELSEKSEESSIEDLQEGSGP-----HIMISYQWDHQKTLVKVKDRLQSYGYRVWMDLEQM--GGSTLQAMAEAVENSVVVLICMSQKYKESPNCRTEAEYTFQLRKQIVPLMMEGKYKPDGWLGAILGAKLYFDFSAQHKFEDSIGKLIKELGQRGRSAQLVQKVQA-VEVGAGGAGALPIMPPAKPRVLDWKQAEVDNWIAENQLEK-NFLRELTGPQLHFLQSLRGE 661
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A1S3HGA3 (uncharacterized protein LOC106155047 OS=Lingula unguis OX=7574 GN=LOC106155047 PE=4 SV=1)

HSP 1 Score: 153.295 bits (386), Expect = 2.362e-35
Identity = 144/618 (23.30%), Postives = 275/618 (44.50%), Query Frame = 2 
Query:  206 VNNDEKLKYLQTIINNFLSKNLIDDLYLSLTKLFNEIKENHTSKEVGNNLPTSFAVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGSLSETELKILELSIRNLYSTLIYDSEVNIHK--LHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSI---SGEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
             N+  K+ ++ T+ N           Y+SL K FN   E  +  E G        ++  IF   S+ + +F + +      +++ +  +       I GS+ +TE +   L++++    +   ++V+  +   H++KV + L+ +      + K    +  AYI  ++ +     +      II +L  ++++ ++ + + +   E+ K +  +++ND+NK  + E G +P L  +L +   +    +LS L  L +D+ NK +I E+               P     +  + K  N     A+N       G  + +      SE  L          ++ DSAS +                     + ++ T       HVMISY   +    LK+ DEL+ R F +W+D   M  +   ++AMA+AVEN+  V+IC+S  YK+S +CR EA+Y+    K ++P+++Q  Y+PDGWLG+ +    + +FSGKY+ E  +  L K+L      + K+    P ++T+ + L  S  +       S W+   V  W  +  + +    +  TG ++ FLK I   + E    +   ++ I  L+D+ +++   K L
Sbjct:  106 ANHMAKIGFVTTLCN----------YYISLLKEFN--NETVSYIETGTLRGAGLLIIRGIFWNYSDASLKFAESV-GLSGYLEYMMNDLDAIDKGVIAGSI-DTEEEGTSLALKSAIGCVHNCAKVDTLRPIFHEMKVVDRLKPYLHTAETENKAVAIMTEAYIINDEQNDILATEDGIFEFIIDLLKQALESDDHRA-EGFSAWEMAKGLGAMARNDQNKTLIAEKGAIPFLAAMLASEDEEEVEEALSTLWKLGFDQNNKRKIQEE---------------PNCFERVKGLTKHKNSRITKAAN-------GVVWILSQNQLSSEDVLQSQ-------ARTDSASLR---------------------EKSASTAAGGKAGHVMISYNWGDQKVLLKVKDELRRRGFNIWMDVEQMGGST--LQAMAEAVENAAVVLICMSDRYKDSPNCRTEAEYSFKLNKDIVPLMMQRNYKPDGWLGMILGSKLFFDFSGKYNFECKVDELAKEL----GNRGKTGGIVP-VMTETAALAPSFGSGKK--NPSHWNKEDVAQWLEKNNLNRMPKFTKLTGEQIAFLKEIHTNAPEFFFCYMTDKMGIVQLQDLVMINNACKNL 649
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A267GVG8 (TIR domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002835g1 PE=4 SV=1)

HSP 1 Score: 151.754 bits (382), Expect = 1.024e-34
Identity = 109/364 (29.95%), Postives = 174/364 (47.80%), Query Frame = 2 
Query:  647 NQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQF 1738
            ++ I     LLV +  +E  +  ++    SI ++I+ L+ S+ +        Y  +EL K V RL+ ND NK  +VE+ ILP++  LL+         ++++L  LS++   + ++  +F         L +L  + Q   S M      L K  S  ++             T  S R  S    P+    +   AS                      ++N + +  + N  HVMISY HE+ +   ++ D+LK    K+WID   M+    L EAMA+AVENS  V++C+S  YK+S +CR EA+YA  N K LIP++++  Y+P GWLGI +    Y +FSGKY  E     LV  +++F
Sbjct:  209 DERISFSALLLVCFALDESKAEFYLGQKESISLLIRTLNRSIDSKNRRCLG-YHTVELTKCVNRLALNDINKELLVELKILPVVHRLLDGGKPDEIGAAVNVLFTLSFNPAVQEQVHREFAS------QLTSLAGQSQW--SNMASLKGLLFKLESTDSM-------------TNHSARKASAVPKPKPKPGEAADASAV--------------------TENLATSTAAGNGFHVMISYQHESKETVARIRDQLKQHRIKVWIDYEQMKDGSTL-EAMAEAVENSSIVLMCMSRKYKDSNNCRLEAEYAHRNSKKLIPLLMERGYKPTGWLGIILGAGLYHDFSGKYPFEAKFPELVAAVQKF 529
[Close]
BLAST of TIR domain-containing protein vs. TrEMBL
Match: A0A1I8GCB8 (TIR domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 151.754 bits (382), Expect = 1.079e-34
Identity = 109/364 (29.95%), Postives = 174/364 (47.80%), Query Frame = 2 
Query:  647 NQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQF 1738
            ++ I     LLV +  +E  +  ++    SI ++I+ L+ S+ +        Y  +EL K V RL+ ND NK  +VE+ ILP++  LL+         ++++L  LS++   + ++  +F         L +L  + Q   S M      L K  S  ++             T  S R  S    P+    +   AS                      ++N + +  + N  HVMISY HE+ +   ++ D+LK    K+WID   M+    L EAMA+AVENS  V++C+S  YK+S +CR EA+YA  N K LIP++++  Y+P GWLGI +    Y +FSGKY  E     LV  +++F
Sbjct:  211 DERISFSALLLVCFALDESKAEFYLGQKESISLLIRTLNRSIDSKNRRCLG-YHTVELTKCVNRLALNDINKELLVELKILPVVHRLLDGGKPDEIGAAVNVLFTLSFNPAVQEQVHREFAS------QLTSLAGQSQW--SNMASLKGLLFKLESTDSM-------------TNHSARKASAVPKPKPKPGEAADAS--------------------AVTENLATSTAAGNGFHVMISYQHESKETVARIRDQLKQHRIKVWIDYEQMKDGSTL-EAMAEAVENSSIVLMCMSRKYKDSNNCRLEAEYAHRNSKKLIPLLMERGYKPTGWLGIILGAGLYHDFSGKYPFEAKFPELVAAVQKF 531
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO41008 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5P1])

HSP 1 Score: 120.939 bits (302), Expect = 3.615e-28
Identity = 55/139 (39.57%), Postives = 90/139 (64.75%), Query Frame = 2 
Query: 1319 SQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQ 1735
            +   P  +  HVM+SY     D  LK+ DEL+A  +K+WID   M  +   +EAMA AVEN+ AV++C+S  YK S +CR+EA+Y+   +K +IP++++ +Y+PDGWLGI +    +++F  K ++  ++  L+K+L Q
Sbjct:  544 TSIGPKPSGHHVMLSYQWGYQDVVLKVRDELRAAGYKVWIDVEQMEGST--LEAMASAVENAAAVLMCVSRAYKESPNCRSEAEYSFQLRKDIIPLMMEPQYKPDGWLGIIVGAKLWMDFRSKDATSSAVQGLIKELGQ 680

HSP 2 Score: 102.449 bits (254), Expect = 2.214e-22
Identity = 59/192 (30.73%), Postives = 103/192 (53.65%), Query Frame = 2 
Query: 1340 NQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLE--QFKNEQQKSEPTKPQIIT------DHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGI 1891
            +Q+H+MISY  +N    L +   LK    K+W+D   M  +   +EAMA+AVEN+  ++I +S  Y++S +CR+EA+YA   +K ++P+++++ YRPDGWLG+ +    +++F  + S +  +  L+K+L+  Q    QQ  +P      T      D  +      +  +   +S W    V  W   IG+
Sbjct: 1010 SQQHIMISYQWDNQKAMLAVNKRLKEAGHKVWMDVEQMGGST--LEAMARAVENASVILIAMSQRYQDSPNCRSEAEYAFQRRKKIVPLMMEQDYRPDGWLGMILGAKLWMDF--RESVDTGIVHLMKELQYNQTAALQQPHDPVTVDTTTVISSPPDKEDGPPGPTDVVDRPDVSKWKKEDVAKWLSDIGL 1197
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO45030 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RU69])

HSP 1 Score: 112.079 bits (279), Expect = 1.481e-25
Identity = 112/465 (24.09%), Postives = 208/465 (44.73%), Query Frame = 2 
Query:  674 LLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYS--SEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIK---KFAWKSHYTG---SELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
            L++AY+++E ++S  +     I  +I +LS S  ++  +    +   EL + + +++ ND NK+ + + G +PIL               + +L N   DE+ +   AE    + FD                              N+N K  I TT    P   E  + L  S        + DS  +   G++  +   +   +    +D      P  N  HVMISY  +     +++  +L+A  +++W+D   M  +   ++AMA AVEN+  V++C+S  YK S +CR+EA+YA   +K ++P+++++ YRPDGWLG+ +    +++FS K +   ++S   L K++   +   + +      +   H  ++   +     I +S WS   V+NW    G++        SH +G     L  L+S S E      + +     L+++ +  +EL KL
Sbjct:  439 LILAYLTDESNNSLIMASEEPIQFLIHILSKSC-SSNSNRYLGFTNSELAEGLSQIAVNDSNKKLIGQHGAIPIL---------------VDMLANAKNDEQRRCG-AEALWVLAFD------------------------------NEN-KEAILTT----PNAVELLKELQHS--------EDDSVKKAAAGVLWEIEGKESHTVKESTADE-----PLRN--HVMISYQWDVQPTMIQVKSKLQAAGYRVWMDLEQMGGS--TLQAMANAVENAEVVLMCVSQKYKESPNCRSEAEYAFQLRKDIVPLMMEKSYRPDGWLGMIMGAKLWIDFSDKQTLRVDDSFEKLQKEI-GMRGRGRGNVVESKLVAVQHDVVDVFPK-----IDISKWSKDDVMNWMNGFGLRLGNDSTIASHLSGKLLQRLAKLRSESPEFFYSSVKQDFGFAHLQEVLLFVDELNKL 828
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO33720 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRG5])

HSP 1 Score: 79.337 bits (194), Expect = 2.220e-18
Identity = 34/70 (48.57%), Postives = 51/70 (72.86%), Query Frame = 2 
Query: 1472 MEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFS 1681
            +EAMA AVENS  V++C S  YK+S + R+EA+YA   KKP++P++++  Y+PDGWLG+ +    Y NF+
Sbjct:    6 LEAMANAVENSAVVLMCASRKYKDSVNYRSEAEYAYTQKKPIVPLMMENGYKPDGWLGMIMGSKLYFNFA 75
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO39316 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAI7])

HSP 1 Score: 73.1738 bits (178), Expect = 4.267e-14
Identity = 42/135 (31.11%), Postives = 79/135 (58.52%), Query Frame = 2 
Query: 1346 KHVMISYCHENADFALKLYDELKARNFKLWIDKH-DMRANQNLMEAMAQAVENSWAVIIC-ISHCYKNSESCRAEAQYAKDNKKP-----LIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQL 1729
            KHVM+SY  +  D   K+YD L+A   ++W+D H  +R + N   +MA+ V+ + A++ C +S  Y  S++C+ E  YA D K       ++P++ ++ ++  GWLGI   G+ +++F  + + E S+  L +++
Sbjct:    2 KHVMLSYQWDIQDLVKKVYDGLRAYGIRVWMDIHGGIRGDIN--GSMAKGVDGA-AILCCFMSTKYSESKNCKKELSYA-DGKTGCEEVIIVPVMCEKGFKAKGWLGIITAGLLWIDFRDEANFENSVKSLAQEI 132
[Close]
BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Match: EDO47001 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN39])

HSP 1 Score: 56.6102 bits (135), Expect = 3.548e-8
Identity = 29/110 (26.36%), Postives = 56/110 (50.91%), Query Frame = 2 
Query: 1355 MISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQE-KYRPDGWLGICITGIQYLNFS 1681
             +SY  +  + AL+L  +L+    + W+D   M    +L  ++   V  +  ++ C++  Y  SE+C+ EA      KKP+IP++ +E  + P G LG     + Y++ +
Sbjct: 1370 FLSYQWDMQETALELGRQLREAGIECWMDVGQMGGGDSLYASIDAGVRGAKVMLCCVTSRYCASENCQCEATLGGLLKKPIIPLLFEEIPWPPAGQLGPVFAKLLYIDMT 1479
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000008941.1 (SMESG000008941.1)

HSP 1 Score: 1318.52 bits (3411), Expect = 0.000e+0
Identity = 662/668 (99.10%), Postives = 663/668 (99.25%), Query Frame = 2 
Query:   41 MGEKATNDIKSVEKNLFDEINKLKILNNVIVHPKNNYFETLFSIGKYFDLIFDNCVNNDEKLKYLQTIINNFLSKNLIDDLYLSLTKLFNEIKENHTSKEVGNNLPTSFAVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGSLSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
            MGEKATNDIKSVE+NLFDEINKLKILNNVIVHPKNNYFETLFSIGKYFDLIFDNCVNNDEKLKYLQTIINNFLSKNLIDDLYLSLTKLFNEIKENHTSKEVGNNLP SF VLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGSLSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSIL NLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNA NQNIKGEIGTTFYIQPP KESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHSNLEQSNENQSNGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL
Sbjct:    1 MGEKATNDIKSVEQNLFDEINKLKILNNVIVHPKNNYFETLFSIGKYFDLIFDNCVNNDEKLKYLQTIINNFLSKNLIDDLYLSLTKLFNEIKENHTSKEVGNNLPRSFTVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGSLSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILFNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPDNHLDKNALNQNIKGEIGTTFYIQPPAKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHSNLEQSNENQSNGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL 668
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000008937.1 (SMESG000008937.1)

HSP 1 Score: 364.77 bits (935), Expect = 3.388e-116
Identity = 222/609 (36.45%), Postives = 353/609 (57.96%), Query Frame = 2 
Query:  284 YLSLTKLFNEIKENHTSKEVGNNLPTSFAVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLPCINGSLSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQ------------HLKTLKPKEQLPISTMNKPD---NHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQK--LNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFK--NEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSIS---GEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
            Y  L ++ + +   + S+E+ N   ++   L+DIF   ++ N +FG E CK + L+  +  II E+K  C+N SLS+    +L + I  LY+T+++D   N   + ++K  + ++   KC    IK    L VAYI+ E +S  F  D+ SI  +I++L  S+ T  +S  Q     EL K + +LSKND+NK+ +VEMGILP+LK  LE +  + + ++L +L +L++DE+NK  I ++F   + +L+            H  T      L   ++  P    N + +   N   K ++ +  Y      E++      N  +I    ++S + K  L+GL   LTN   E + S   +  ++    + + H+M+SY   NAD  +K+YD L  + FKLWIDK++M   +NLME+MAQA++NS+AV+I IS  YKNS++CRAEAQYA   KKP+IP+++QEKYRPDGWLGICI G+QY +F+G+Y+ E+++ +L+KQ+++ K  N Q+K +        DH +         N   ++ W+N +  NWF +IGIK   W  HYTG+EL+FL++IS   GE   +  ++EL+I DLKD+RIL + L+ L
Sbjct:  109 YTILVQILHNVFGKNYSEEIDNKFHSAIKNLIDIFFNYTDANSDFGKEFCKNDKLLHLYYKIISEFKENCLNKSLSKNLTDLLRICISTLYNTMLHDVNENYTIIKEMKFLDLIKDLMKCEEGKIKRAALLFVAYIAGETESKMFKSDLHSISYLIELLKKSLNT-RFSRSQGLSTEELSKGIGKLSKNDENKQLLVEMGILPVLKMQLEKDDKRNQELALGVLWSLTFDEKNKILIQKEFRNKILELKTKLDKKCQAGLTHDITGSQVPTLQTHSVESPAINCNRIPEIIGNLESKKDMNSVSYDDVLCFETQ---FDENTEEI---SKNSFNYKNILDGLTWTLTNL--EEVKSKKQE--TEEEEVATKDHIMLSYSWSNADIVMKIYDCLVNKGFKLWIDKYNMSEEENLMESMAQAIQNSYAVVIFISQNYKNSDNCRAEAQYAISKKKPVIPVMVQEKYRPDGWLGICIIGLQYCDFAGRYNFEDALILLLKQIKRIKAGNVQKKIDE------IDHIDPVHVKNQSKNNQDITKWANERCKNWFDEIGIKSIVWPKHYTGNELDFLRTISQVPGEVFYQITKNELKITDLKDLRILFQNLQIL 700
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000008947.1 (SMESG000008947.1)

HSP 1 Score: 279.641 bits (714), Expect = 1.261e-83
Identity = 179/522 (34.29%), Postives = 296/522 (56.70%), Query Frame = 2 
Query:  521 LKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDI--SSIPIIIKVLS---DSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPI--STMNKPDNHLDKNASN-QNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQ-----QKSE-PTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
            ++IL  +I   Y+  I  +   I  LH +K  E +Q F   P + IK+   LL+A++S E   S F ++I     P  +  L+   +   T  +   + Y ILEL + +E+LSK D+NKR +V+ GILP+L  L++    +Y+ ISLSIL NL+++++N+  I   F  I+ D +       +++ P+   T+ K D    +N    +N+   +  T  +  P K                    +    L+GL  IL +++  +      +++++   S  + H MISY H NA   + +Y  L+ + FK+WIDK+++  ++N+MEAMAQAVENS AVII +S  YKNSE CR+EAQYA    KPLIP++++++Y PDGWLG+CI+G+QY +F+ K   ++SM +L  Q+   KN +     +KS+ P +P + ++ S               ++W++ +V  W ++IG++K  WK++Y G ++ FLKS+S EK L+ C+ + ++ DLK++RI  EEL+KL
Sbjct:  260 IQILNDTITIPYTISINGNPEQIAVLHSMKFVELIQDFLLSPYERIKLNSLLLIAHLSSE---SHFKLEIIQEKRPEYLSYLTQLLNKYMTDYHGQTRAYSILELARGIEKLSKVDENKRILVKCGILPVLMLLIKNKSMRYKKISLSILWNLAFNKKNRQVINSMFSDIISDFR-------RDRFPLLYGTLTKNDKRKTQNDLELRNVTENLNETEKM--PRK--------------------TYINVLDGLKWILQDHRNNSKTRDACEDSNEI--SERETHFMISYSHSNAKIVMDIYQILQKQGFKVWIDKYNINDDENMMEAMAQAVENSIAVIIFLSTKYKNSEYCRSEAQYAFKLNKPLIPVVVEKEYHPDGWLGLCISGLQYFDFTSKTPFKKSMALLTDQISTIKNRRFSKIFEKSDFPKEPSVPSNPSP--------------NNWTHEEVKTWLKKIGVRKIKWKANYAGQDIMFLKSLSKEKFLDICRIDFKMSDLKEMRIFYEELEKL 733
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000008947.1 (SMESG000008947.1)

HSP 1 Score: 279.641 bits (714), Expect = 2.223e-83
Identity = 179/522 (34.29%), Postives = 296/522 (56.70%), Query Frame = 2 
Query:  521 LKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEKCPNQDIKIRLALLVAYISEEKDSSGFVVDI--SSIPIIIKVLS---DSVKTAEYSSKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHISLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPI--STMNKPDNHLDKNASN-QNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSASQKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQ-----QKSE-PTKPQIITDHXXXXXXXXXXXXGIKLSDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSELEIYDLKDIRILSEELKKL 2044
            ++IL  +I   Y+  I  +   I  LH +K  E +Q F   P + IK+   LL+A++S E   S F ++I     P  +  L+   +   T  +   + Y ILEL + +E+LSK D+NKR +V+ GILP+L  L++    +Y+ ISLSIL NL+++++N+  I   F  I+ D +       +++ P+   T+ K D    +N    +N+   +  T  +  P K                    +    L+GL  IL +++  +      +++++   S  + H MISY H NA   + +Y  L+ + FK+WIDK+++  ++N+MEAMAQAVENS AVII +S  YKNSE CR+EAQYA    KPLIP++++++Y PDGWLG+CI+G+QY +F+ K   ++SM +L  Q+   KN +     +KS+ P +P + ++ S               ++W++ +V  W ++IG++K  WK++Y G ++ FLKS+S EK L+ C+ + ++ DLK++RI  EEL+KL
Sbjct:  280 IQILNDTITIPYTISINGNPEQIAVLHSMKFVELIQDFLLSPYERIKLNSLLLIAHLSSE---SHFKLEIIQEKRPEYLSYLTQLLNKYMTDYHGQTRAYSILELARGIEKLSKVDENKRILVKCGILPVLMLLIKNKSMRYKKISLSILWNLAFNKKNRQVINSMFSDIISDFR-------RDRFPLLYGTLTKNDKRKTQNDLELRNVTENLNETEKM--PRK--------------------TYINVLDGLKWILQDHRNNSKTRDACEDSNEI--SERETHFMISYSHSNAKIVMDIYQILQKQGFKVWIDKYNINDDENMMEAMAQAVENSIAVIIFLSTKYKNSEYCRSEAQYAFKLNKPLIPVVVEKEYHPDGWLGLCISGLQYFDFTSKTPFKKSMALLTDQISTIKNRRFSKIFEKSDFPKEPSVPSNPSP--------------NNWTHEEVKTWLKKIGVRKIKWKANYAGQDIMFLKSLSKEKFLDICRIDFKMSDLKEMRIFYEELEKL 753
[Close]
BLAST of TIR domain-containing protein vs. Planmine SMEST
Match: SMESG000035587.1 (SMESG000035587.1)

HSP 1 Score: 109.383 bits (272), Expect = 1.238e-24
Identity = 75/221 (33.94%), Postives = 114/221 (51.58%), Query Frame = 2 
Query: 1241 QKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFALKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYKNSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKYSSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHXXXXXXXXXXXXGIKLSD----WSNSKVINWFRQIGI 1891
            Q  NG++ IL N     + S P  N  +T    +     +SY   N D  L++   LK+ N  +WID+ +M ++   +EAMA  +ENS  V+I  S  YKNS +CR EA+YA+  KKP+IP++++ KY+P  WLGI      Y+ FS + ++ E +  L+K ++   N      P K     D +  E++  N    I L D    WS   V +W  + GI
Sbjct:  328 QHYNGILWILDN----KLESLPKGNTEKTAIVFD---AFMSYSWANKDKVLEICSILKSYNVNVWIDQEEMISST--LEAMATGIENSKVVVIAASTAYKNSSNCRLEAEYAQKIKKPIIPLVMEHKYKPSNWLGILFGTKVYIEFSDRRNANEQVQQLIKNIKFHLN-----RPVKLAEKIDLNAGEKNRSNSRTRIVLVDEVKNWSCENVGDWLDKFGI 534
The following BLAST results are available for this feature:
BLAST of TIR domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A210PZ211.706e-3526.38Vacuolar protein 8 OS=Mizuhopecten yessoensis OX=6... [more]
C3YBW81.947e-3526.94Uncharacterized protein OS=Branchiostoma floridae ... [more]
A0A1S3HGA32.362e-3523.30uncharacterized protein LOC106155047 OS=Lingula un... [more]
A0A267GVG81.024e-3429.95TIR domain-containing protein (Fragment) OS=Macros... [more]
A0A1I8GCB81.079e-3429.95TIR domain-containing protein OS=Macrostomum ligna... [more]
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BLAST of TIR domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO410083.615e-2839.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO450301.481e-2524.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO337202.220e-1848.57Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO393164.267e-1431.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO470013.548e-826.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TIR domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TIR domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000008941.10.000e+099.10SMESG000008941.1[more]
SMESG000008937.13.388e-11636.45SMESG000008937.1[more]
SMESG000008947.11.261e-8334.29SMESG000008947.1[more]
SMESG000008947.12.223e-8334.29SMESG000008947.1[more]
SMESG000035587.11.238e-2433.94SMESG000035587.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021086 ID=SMED30021086|Name=TIR domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2069bp
TCATAAGCGTTAATTATCTATCTTTATTAAAAAATCCAGGATGGGGGAAA
AAGCCACTAATGATATTAAATCCGTAGAAAAAAATCTTTTCGACGAAATA
AACAAATTAAAAATCCTTAACAATGTTATAGTTCATCCGAAAAATAATTA
TTTTGAAACTTTATTTTCGATTGGAAAATATTTTGACTTAATTTTCGACA
ATTGCGTAAATAATGATGAAAAATTGAAATACCTACAAACAATTATTAAT
AATTTCCTATCAAAAAATCTGATAGACGATTTATATTTATCTCTAACTAA
GTTATTTAATGAAATTAAAGAAAATCACACAAGTAAAGAAGTGGGCAATA
ATTTACCTACATCATTTGCCGTTTTGTTGGATATTTTTGCCCGATGTTCT
GAAACGAATCAAGAATTTGGAGATGAAATTTGCAAAAGAGAAAATTTAAT
CCAATTTTTCGTTATGATTATCAAGGAATATAAATTACCTTGCATAAATG
GCTCATTATCGGAGACGGAGTTAAAGATTCTGGAATTAAGTATCAGGAAT
CTTTACAGTACTCTCATCTACGACTCAGAAGTCAATATTCACAAACTTCA
TAAGCTAAAGGTTTGGGAATCTCTTCAATATTTTGAAAAATGTCCTAATC
AAGATATTAAAATAAGACTTGCATTGCTTGTTGCGTATATTTCGGAAGAA
AAGGATTCTAGTGGTTTTGTCGTAGATATTAGTTCTATTCCTATTATCAT
TAAAGTATTATCTGATTCAGTTAAAACTGCGGAATATTCATCAAAGCAAG
AATATCCAATTCTTGAATTAATTAAAGCTGTCGAAAGGTTGTCCAAAAAT
GACAAAAACAAAAGAAAAATGGTTGAAATGGGAATTCTACCAATTCTTAA
AACACTATTGGAAACTAATTTCACAAAATATCGTCATATTTCATTATCAA
TCCTTCTTAATTTGTCCTACGATGAAAGAAATAAAAGTGAAATTGCGGAA
AAGTTTTTACAGATACTTTTTGATTTGCAACATTTGAAAACTCTTAAACC
AAAGGAACAATTGCCAATTTCCACAATGAATAAACCAGATAATCATTTAG
ACAAAAATGCATCAAATCAAAATATTAAAGGAGAAATTGGTACCACTTTT
TATATTCAACCCCCAACCAAGGAATCTGAGCGAGCTCTATCACAATCAAA
TAATCCACAGATTTATGGAAGTCAGCAGGACTCGGCATCACAGAAATTAA
ATGGACTCATGTCAATATTAACAAATTATCAAAAAGAAAACATTCCATCT
CCCCCCAGTGATAATAATTCTCAGACAAATCCTTCATCCAATCAAAAGCA
TGTGATGATCAGTTATTGCCATGAAAATGCTGATTTTGCATTGAAACTCT
ACGACGAATTGAAAGCCAGAAATTTTAAACTTTGGATCGACAAACACGAC
ATGAGGGCAAATCAAAATTTGATGGAAGCGATGGCACAGGCAGTGGAAAA
TTCGTGGGCAGTGATAATCTGTATTTCTCATTGTTATAAAAATAGTGAAT
CATGCCGAGCTGAGGCTCAATACGCCAAGGACAACAAAAAGCCTTTAATT
CCAATAATAATCCAAGAAAAATACCGTCCAGATGGATGGCTAGGAATATG
CATAACTGGAATTCAATATCTTAATTTTTCTGGCAAATACTCTTCCGAAG
AATCTATGGGAATGCTAGTCAAGCAGTTAGAACAGTTCAAAAATGAGCAA
CAGAAATCTGAACCCACAAAGCCTCAGATCATAACTGACCATTCAAATTT
AGAACAATCCAATGAGAATCAAAGCAACGGGATAAAACTCAGTGATTGGT
CAAATTCAAAAGTCATAAATTGGTTTCGTCAAATCGGAATTAAAAAATTT
GCTTGGAAAAGTCATTATACCGGCTCAGAATTGGAATTTTTAAAAAGTAT
TTCTGGTGAAAAATTGCTGGAATTCTGTCAATCTGAATTAGAAATCTATG
ATTTGAAAGATATTCGTATACTGTCTGAAGAATTGAAAAAATTATGAATT
TATTCTTAGTTTAATGTGA
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protein sequence of SMED30021086-orf-1

>SMED30021086-orf-1 ID=SMED30021086-orf-1|Name=SMED30021086-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=669bp
MGEKATNDIKSVEKNLFDEINKLKILNNVIVHPKNNYFETLFSIGKYFDL
IFDNCVNNDEKLKYLQTIINNFLSKNLIDDLYLSLTKLFNEIKENHTSKE
VGNNLPTSFAVLLDIFARCSETNQEFGDEICKRENLIQFFVMIIKEYKLP
CINGSLSETELKILELSIRNLYSTLIYDSEVNIHKLHKLKVWESLQYFEK
CPNQDIKIRLALLVAYISEEKDSSGFVVDISSIPIIIKVLSDSVKTAEYS
SKQEYPILELIKAVERLSKNDKNKRKMVEMGILPILKTLLETNFTKYRHI
SLSILLNLSYDERNKSEIAEKFLQILFDLQHLKTLKPKEQLPISTMNKPD
NHLDKNASNQNIKGEIGTTFYIQPPTKESERALSQSNNPQIYGSQQDSAS
QKLNGLMSILTNYQKENIPSPPSDNNSQTNPSSNQKHVMISYCHENADFA
LKLYDELKARNFKLWIDKHDMRANQNLMEAMAQAVENSWAVIICISHCYK
NSESCRAEAQYAKDNKKPLIPIIIQEKYRPDGWLGICITGIQYLNFSGKY
SSEESMGMLVKQLEQFKNEQQKSEPTKPQIITDHSNLEQSNENQSNGIKL
SDWSNSKVINWFRQIGIKKFAWKSHYTGSELEFLKSISGEKLLEFCQSEL
EIYDLKDIRILSEELKKL*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0000221vacuolar proton-transporting V-type ATPase, V1 domain
Vocabulary: molecular function
TermDefinition
GO:0046961proton-transporting ATPase activity, rotational mechanism
GO:0005515protein binding
GO:0005488binding
Vocabulary: biological process
TermDefinition
GO:1902600hydrogen ion transmembrane transport
GO:0007165signal transduction
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR035897Toll_tir_struct_dom_sf
IPR011989ARM-like
IPR000157TIR_dom
IPR001660SAM
IPR016024ARM-type_fold
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR011989Armadillo-like helicalGENE3DG3DSA:1.25.10.10coord: 117..345
e-value: 2.9E-7
score: 31.5
IPR035897Toll/interleukin-1 receptor homology (TIR) domain superfamilyGENE3DG3DSA:3.40.50.10140coord: 396..532
e-value: 4.0E-24
score: 86.9
IPR035897Toll/interleukin-1 receptor homology (TIR) domain superfamilySUPERFAMILYSSF52200Toll/Interleukin receptor TIR domaincoord: 431..551
IPR000157Toll/interleukin-1 receptor homology (TIR) domainPFAMPF13676TIR_2coord: 438..557
e-value: 2.4E-25
score: 89.4
IPR000157Toll/interleukin-1 receptor homology (TIR) domainPROSITEPS50104TIRcoord: 434..525
score: 9.62
NoneNo IPR availablePANTHERPTHR46270FAMILY NOT NAMEDcoord: 182..668
IPR001660Sterile alpha motif domainPROSITEPS50105SAM_DOMAINcoord: 603..668
score: 8.805
IPR016024Armadillo-type foldSUPERFAMILYSSF48371ARM repeatcoord: 160..331