Protein kinase domain-containing protein
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021070 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 22Note: Hover over icons to view figure legend
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 127.102 bits (318), Expect = 9.554e-30 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 358 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 560
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 127.102 bits (318), Expect = 1.008e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 389 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 591
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 126.716 bits (317), Expect = 1.060e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 564
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 127.102 bits (318), Expect = 1.085e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 595
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855]) HSP 1 Score: 127.102 bits (318), Expect = 1.085e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 393 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 595
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: mtk-1 (MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O01837]) HSP 1 Score: 127.102 bits (318), Expect = 1.083e-29 Identity = 74/201 (36.82%), Postives = 111/201 (55.22%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEI----------GTGNQYGTPVDIWSLGATVLFMLTGK 1412
I G+FG V++ + + R+ A K M I + N ++++ IN F+ ++ HE ++KYYG ED+ + I MEY G+LE + K + +Y+ +L +++LH + IIHRD+KP NI LD +KL DFG L + T G+ F APEI G+ + YG VDIW+LGATV+ M+TGK
Sbjct: 1131 IASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLI-HENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGKMDLKMVR---QYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGK 1327
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: mtk-1 (MTK1/MEKK4 homolog [Source:UniProtKB/TrEMBL;Acc:O01837]) HSP 1 Score: 127.102 bits (318), Expect = 1.132e-29 Identity = 74/201 (36.82%), Postives = 111/201 (55.22%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEI----------GTGNQYGTPVDIWSLGATVLFMLTGK 1412
I G+FG V++ + + R+ A K M I + N ++++ IN F+ ++ HE ++KYYG ED+ + I MEY G+LE + K + +Y+ +L +++LH + IIHRD+KP NI LD +KL DFG L + T G+ F APEI G+ + YG VDIW+LGATV+ M+TGK
Sbjct: 1131 IASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLI-HENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGKMDLKMVR---QYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGK 1327
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356]) HSP 1 Score: 121.324 bits (303), Expect = 5.607e-28 Identity = 88/271 (32.47%), Postives = 140/271 (51.66%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE--------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + T +L A+K M IN+ + +K+ IN + +H + YYGA + +L++VME+ +GS+ D + K ++ + Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LDK +G T G+ Y+ APE+ ++ Y + D+WSLG T L M G + L + + P++ + T K+ TF+E +L KD +R ALL+
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWT---KKFETFIETVLVKDYHQRPYTGALLR 284
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356]) HSP 1 Score: 121.324 bits (303), Expect = 6.691e-28 Identity = 88/271 (32.47%), Postives = 140/271 (51.66%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE--------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + T +L A+K M IN+ + +K+ IN + +H + YYGA + +L++VME+ +GS+ D + K ++ + Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LDK +G T G+ Y+ APE+ ++ Y + D+WSLG T L M G + L + + P++ + T K+ TF+E +L KD +R ALL+
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWT---KKFETFIETVLVKDYHQRPYTGALLR 284
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: mig-15 (Serine/threonine-protein kinase mig-15 [Source:UniProtKB/Swiss-Prot;Acc:Q23356]) HSP 1 Score: 120.939 bits (302), Expect = 7.097e-28 Identity = 88/271 (32.47%), Postives = 140/271 (51.66%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE--------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + T +L A+K M IN+ + +K+ IN + +H + YYGA + +L++VME+ +GS+ D + K ++ + Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LDK +G T G+ Y+ APE+ ++ Y + D+WSLG T L M G + L + + P++ + T K+ TF+E +L KD +R ALL+
Sbjct: 20 IFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRNPPPKLKRNKKWT---KKFETFIETVLVKDYHQRPYTGALLR 284
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0333364) HSP 1 Score: 124.405 bits (311), Expect = 7.741e-29 Identity = 92/265 (34.72%), Postives = 137/265 (51.70%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTGKK----LEKLEN-SVTPQMS-KLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VMEY GS+ D + K ++ + Y ++IL GL +LH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WSLG T L M + L + + P+ S L K K+ F++ +L KD +R E LLK
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLK 292
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0333365) HSP 1 Score: 124.405 bits (311), Expect = 8.678e-29 Identity = 92/265 (34.72%), Postives = 137/265 (51.70%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTGKK----LEKLEN-SVTPQMS-KLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VMEY GS+ D + K ++ + Y ++IL GL +LH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WSLG T L M + L + + P+ S L K K+ F++ +L KD +R E LLK
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLK 292
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072957) HSP 1 Score: 124.405 bits (311), Expect = 8.678e-29 Identity = 92/265 (34.72%), Postives = 137/265 (51.70%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTGKK----LEKLEN-SVTPQMS-KLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VMEY GS+ D + K ++ + Y ++IL GL +LH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WSLG T L M + L + + P+ S L K K+ F++ +L KD +R E LLK
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLK 292
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072959) HSP 1 Score: 124.405 bits (311), Expect = 9.023e-29 Identity = 92/265 (34.72%), Postives = 137/265 (51.70%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTGKK----LEKLEN-SVTPQMS-KLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VMEY GS+ D + K ++ + Y ++IL GL +LH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WSLG T L M + L + + P+ S L K K+ F++ +L KD +R E LLK
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLK 292
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: msn (gene:FBgn0010909 transcript:FBtr0072958) HSP 1 Score: 124.405 bits (311), Expect = 9.023e-29 Identity = 92/265 (34.72%), Postives = 137/265 (51.70%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTGKK----LEKLEN-SVTPQMS-KLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+FE +G+GT+G VYK + + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VMEY GS+ D + K ++ + Y ++IL GL +LH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WSLG T L M + L + + P+ S L K K+ F++ +L KD +R E LLK
Sbjct: 31 IFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLK 292
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 132.88 bits (333), Expect = 6.975e-32 Identity = 78/206 (37.86%), Postives = 117/206 (56.80%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 343 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 546
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 132.88 bits (333), Expect = 7.940e-32 Identity = 78/206 (37.86%), Postives = 117/206 (56.80%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 558
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1]) HSP 1 Score: 132.494 bits (332), Expect = 8.964e-32 Identity = 78/206 (37.86%), Postives = 117/206 (56.80%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 361 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 564
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 128.257 bits (321), Expect = 2.289e-30 Identity = 78/202 (38.61%), Postives = 116/202 (57.43%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG V+ ++ TGR AVK + + + E +L+ I +N+ HERI++YYG + T + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG R L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT +
Sbjct: 357 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLF-HERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTR-KYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQR 556
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 128.257 bits (321), Expect = 2.321e-30 Identity = 78/202 (38.61%), Postives = 116/202 (57.43%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG V+ ++ TGR AVK + + + E +L+ I +N+ HERI++YYG + T + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG R L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT +
Sbjct: 365 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLF-HERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTR-KYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQR 564
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 130.183 bits (326), Expect = 6.178e-31 Identity = 78/202 (38.61%), Postives = 117/202 (57.92%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG VY ++ TGR AVK + + + E +L+ I +N+L HERI++YYG + +++ L I MEY+ GS++D++ + +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT K
Sbjct: 342 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTR-KYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEK 541
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570]) HSP 1 Score: 129.798 bits (325), Expect = 9.227e-31 Identity = 78/202 (38.61%), Postives = 117/202 (57.92%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG VY ++ TGR AVK + + + E +L+ I +N+L HERI++YYG + +++ L I MEY+ GS++D++ + +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT K
Sbjct: 370 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTR-KYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEK 569
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 128.257 bits (321), Expect = 3.416e-30 Identity = 78/205 (38.05%), Postives = 117/205 (57.07%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+H+RI++YYG++ + + L I MEY+ GS++D++ +N RY++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 347 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKN-LHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-RYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 549
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742]) HSP 1 Score: 127.872 bits (320), Expect = 3.958e-30 Identity = 78/205 (38.05%), Postives = 117/205 (57.07%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+H+RI++YYG++ + + L I MEY+ GS++D++ +N RY++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 365 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKN-LHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-RYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 567
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862]) HSP 1 Score: 125.946 bits (315), Expect = 1.911e-29 Identity = 89/259 (34.36%), Postives = 139/259 (53.67%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQ------NILNHERIIKYYGAITEDT--KLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK----KLEKLEN----SVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
G +G G FG+VY + GR AVK + + + E+ K +NA + + HERI++YYG + + T KL I +EY+ GS++D++ +N RY++QIL+G+ +LH N I+HRD+K NIL D NVKL DFG + + S ++ G+ Y+ +PE+ +G YG D+WS+ TV+ MLT K + E + + P +L D V F++ + ++ KRR TAE LL+
Sbjct: 357 GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSK-EVNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTR-RYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVISGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRLPDT--VSDACRDFMKQIFVEE-KRRPTAEELLR 610
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873]) HSP 1 Score: 127.102 bits (318), Expect = 5.336e-30 Identity = 78/202 (38.61%), Postives = 115/202 (56.93%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG VY + TGR AVK + N + E +L+ I +N+L HERI++YYG + ++ L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D N+KL DFG + L S ++ G+ Y+ +PE+ +G YG DIWS+ TV+ MLT K
Sbjct: 359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLL-HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTR-KYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEK 558
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874]) HSP 1 Score: 126.716 bits (317), Expect = 6.899e-30 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITEDTK--LYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 564
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map4k2 (mitogen-activated protein kinase kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346883]) HSP 1 Score: 122.865 bits (307), Expect = 2.536e-28 Identity = 84/259 (32.43%), Postives = 132/259 (50.97%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVN-AESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ---YGTPVDIWSLGATV---------LFMLTGKKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
FE ++G GT+GDVYK +++VT L AVK + ++ + SL+ I + H ++ Y G+ + +L+I ME+ GSL++ + + ++ L+GL HLH G IHRD+K N+LL + +VKLADFG+ L + + G+ Y+ APE+ + Y D+W+LG T LF L + L + + Q KL D T+ + FL+ L K+PK+R TAE LL+
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILREC-RHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAY-VCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKR---RSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQ 269
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map4k2 (mitogen-activated protein kinase kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346883]) HSP 1 Score: 122.865 bits (307), Expect = 2.536e-28 Identity = 84/259 (32.43%), Postives = 132/259 (50.97%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVN-AESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ---YGTPVDIWSLGATV---------LFMLTGKKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
FE ++G GT+GDVYK +++VT L AVK + ++ + SL+ I + H ++ Y G+ + +L+I ME+ GSL++ + + ++ L+GL HLH G IHRD+K N+LL + +VKLADFG+ L + + G+ Y+ APE+ + Y D+W+LG T LF L + L + + Q KL D T+ + FL+ L K+PK+R TAE LL+
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILREC-RHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAY-VCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKR---RSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQ 269
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Tnik (TRAF2 and NCK interacting kinase [Source:MGI Symbol;Acc:MGI:1916264]) HSP 1 Score: 122.094 bits (305), Expect = 6.786e-28 Identity = 89/275 (32.36%), Postives = 138/275 (50.18%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
+FE +G+GT+G VYK + TG+L A+K M + E +K IN + +H I YYGA + D +L++VME+ GS+ D I K + ++ + Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LD+ +G T G+ Y+ APE+ ++ Y D+WSLG T + M G + L + + P+ L K K+ +F+E L K+ +R E L+K R+
Sbjct: 24 IFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR---NTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPR----LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 291
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CAD5|YODA_ARATH (Mitogen-activated protein kinase kinase kinase YODA OS=Arabidopsis thaliana OX=3702 GN=YDA PE=1 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 7.846e-31 Identity = 112/357 (31.37%), Postives = 160/357 (44.82%), Query Frame = 3
Query: 549 DNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFI------NKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPE-IGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLLDLTKVP-------KEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
DNR+ H + LL+ C P A +PS +P P R + P S KK G +G G+FG VY S +G + A+K + + ++ +A+ L I+ L H+ I++YYG+ T D KLYI +EYV GS+ + + +N Y++QIL GL +LH +HRD+K NIL+D VK+ADFG+ + + G P++ KGS Y+ APE I N VDIWSLG TVL M T K V P M K+ + ++P +E F+ L ++P R TA LL RN
Sbjct: 350 DNRQQSH------RLPLPPLLISNTCPFSPTYSAATSPS------------------VPRSPAR-------------AEATVSPGSRWKK----GRLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSR-LRHQNIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIR-NYTQQILSGLAYLHAKNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQSG----PLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCTVLEMATTKPPWSQYEGV-PAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAAQLLDHAFVRN 658
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q54PX0|Y4251_DICDI (Probable serine/threonine-protein kinase DDB_G0284251 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0284251 PE=3 SV=1) HSP 1 Score: 126.331 bits (316), Expect = 2.321e-29 Identity = 87/256 (33.98%), Postives = 135/256 (52.73%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNI--LNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTG-------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMF 1571
G KIG G FG V+K TG A+K + NK++ SL+ + + L H I+K G + +L ++EYV NGSL D I K + I+ Y Q+L+GL +LH N +IHRD+K NIL+ E +KLADFG+ +D + + ++ G+ Y+ APE + + DIWSLG+T++ +LTG + + + V+ Q T + KE + + + KDP +R TA+ LL+ +F
Sbjct: 39 GEKIGRGAFGQVFKGLNGKTGEFVAIKQIDSNKIDESSLQSVKGEVEILHKLRHNNIVKVLGVVEVQAQLNFILEYVENGSLRDVIEKFGPLSEELCII-YLYQMLQGLAYLHSNKVIHRDIKASNILITKEGVIKLADFGVASQID---SESQLRFSVVGTPYWMAPESIEISGCSSASDIWSLGSTMIELLTGNPPYYTLQPMAAMFRIVSDQHPPF--PTDISKEFLDYFQQSFKKDPTQRPTAQELLQHPIF 288
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q7RZD3|STE20_NEUCR (Serine/threonine-protein kinase ste20 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) OX=367110 GN=stk-4 PE=3 SV=1) HSP 1 Score: 128.257 bits (321), Expect = 4.078e-29 Identity = 85/267 (31.84%), Postives = 133/267 (49.81%), Query Frame = 3
Query: 789 KFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSV----------TPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
+ C ++++ G TKIG G G VY E + RL A+K M + + + L +N +H I+ + + +L++VMEY+ GSL D + V ++ L GL+HLH G+IHRD+K NILL E N+KL DFG +++ T+ G+ Y+ APE+ T +YG VDIWSLG + M+ G+ E+ + TP + L+ V ++ FL + L DP++R +A LL+
Sbjct: 663 RICSDGDPREIYRGFTKIGQGASGGVYTGHERGSNRLVAIKQMNLEQQPKKDLIINEILVMKESSHPNIVNFIDSYLCAGELWVVMEYMEGGSLTDVVTFNIMTEGQIASV--CRETLRGLQHLHSKGVIHRDIKSDNILLSMEGNIKLTDFGFCATINEAQSKRT---TMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALWLIATNGTPHIKDEQSLSPVFRD---FLYFALKVDPEKRASAHDLLR 921
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1) HSP 1 Score: 126.716 bits (317), Expect = 4.826e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITEDTK--LYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 564
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2) HSP 1 Score: 126.716 bits (317), Expect = 5.092e-29 Identity = 77/205 (37.56%), Postives = 115/205 (56.10%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L HERI++YYG + + + L I MEY+ GS++D++ ++ +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 564
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0H3YJG2 (Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc42a-1 PE=2 SV=1) HSP 1 Score: 197.978 bits (502), Expect = 3.119e-49 Identity = 139/434 (32.03%), Postives = 217/434 (50.00%), Query Frame = 3
Query: 396 RDPVIKIVEKYEDETIINI----LKARKFLLACKKGDLETVRSMLTD-VNVEYCDKDNRRPIHWAVEGGHTEIVKLL---------------------------------LEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLLDLTK---------VPKEMVTFLEYMLDKDPKRRWTAEALL 1556
+D I+ V+KY I+ I L ACK G + V+ + NV+ D + RR +H+AV + +IVKLL +E CD+ DK +P IA+ + ++IK+ +E + +R++ + M +KC C+HKFC TS ++K + I G++G V+ + ES T R FAVK + + A ++ NIN F+N+L HERI+K++GA + YI MEY L+ KK D++ ++KQILE L LH+ IIHRD+KP N+LLD + N+KL+DFG+ +L G+ + APEI Y VDIWSLGAT++ + TG+ N + ++ T+ +PK + +++ML+KD +R +A+ LL
Sbjct: 515 KDGSIEDVKKYYSRRILEIKLGSYSRSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETGDFENMIKLIKEC---QIIREIAAEMQLKCGKLCNHKFCYTSFQRKKIKNRKCIASGSYGTVFLYNESGTDRKFAVKKIPKQNIRARYIEANINDFKNLLCHERIVKHFGAFHKKENHYIFMEY-----LDTLQKKKYQKKSPGDLLLFAKQILEALSFLHERSIIHRDIKPENVLLDIDGNLKLSDFGLSLLLSSVAEDIQKEGRCCGTYCYAAPEILNAELYTCSVDIWSLGATMIQLCTGQ--PPYHNLGDGAIITVISTTREIEYKLPEYMPKYISNLIDHMLEKDQYKRLSAKKLL 938
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A5B8MXT0 (Mitogen-activated protein kinase OS=Chloropicon primus OX=1764295 GN=A3770_17p78750 PE=4 SV=1) HSP 1 Score: 162.54 bits (410), Expect = 4.636e-38 Identity = 139/453 (30.68%), Postives = 217/453 (47.90%), Query Frame = 3
Query: 297 SGMRPIQVAC-YAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLT-DVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLI-------KIFEEN--LPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINA------FQNILNHERIIKYYGAITEDTK--LYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGR--VLDKGIGSTII-PMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKK-LEKLENSVTP--QMSKLLDLTKVPKEMVT----FLEYMLDKDPKRRWTAEALLKLEM 1568
SG P+Q A Y + + E+L D+ + + DP+ + ++ +I +ACK G E ++T +V D+D P+H A GH +++L Q I + K GL P +A DL K EE+ +PERP + +SM + S + + ++ G +G G +G VY TG++ AVK + ++ N + N+ A F L HE I++YYGA + + +Y+ +EYV GS+ + + + + Y+KQIL GL LH+N IHRD+K NIL+ E + KLADFG + V + GS + ++ GS Y+ APE+ G +G DIWSLG TV+ MLTGK ++ +N+ T Q++K +PK + FL+ DP +R TA LL +
Sbjct: 247 SGRTPLQEAVFYDQGERAKELL-----DVGVDADLDPLRGAGQHHQGSPLI---------IACKLGHHEVADLLITYGASVHCVDQDAFTPLHHACAEGHARCAEVVLSQGASIRARTKGGLTPLQLASTDGVRDLFNPSSRSRKAEEEDGGVPERPRGRDSNSMFRESSKRIESG-------EMEWKKGELLGEGAYGRVYAGLNHETGQIMAVKQIAVDMDNDKHTD-NLKALEREIEFYKTLKHEHIVEYYGAFLDKDQHLMYVFLEYVSGGSISSMLKRFGPFSEALTKI-YTKQILRGLLFLHENKTIHRDVKGANILITQEGSAKLADFGASKRYVNAENSGSGLSNSKSITGSVYWMAPEVMKGTGHGRKADIWSLGCTVVEMLTGKHPWKEYDNTWTAMFQIAKSESGPGLPKNISKDAREFLQLCFQLDPTKRPTALDLLGTQF 676
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: K1PKP1 (Mitogen-activated protein kinase kinase kinase 2 OS=Crassostrea gigas OX=29159 GN=CGI_10008499 PE=4 SV=1) HSP 1 Score: 145.976 bits (367), Expect = 7.825e-35 Identity = 98/268 (36.57%), Postives = 148/268 (55.22%), Query Frame = 3
Query: 795 CPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILN------HERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK----KLEKLENSVTPQMSKLLDLTKVPKEMVTF----LEYMLDKDPKRRWTAEALL 1556
CP + ++ G +G G FG+VY + TGR A+K + + ++NAE+ K + A +N ++ HERI+ Y+G + LYI MEY+ GS++D+I K + +N +Y+KQ+LEGL +LHKN I+HRD+K NIL DG N+KL DFG + L + +T + ++ G+ Y+ APE+ G YG DIWS+G T++ MLT K + E + M K T +P + L D++P R TA LL
Sbjct: 60 CPVN-----WKAGALLGSGAFGEVYVCHDKDTGRDLAMKVVRLEQMNAETSK-EVRALENEIHLLRNFEHERIVSYFGCAQDKQSLYIFMEYLPGGSVKDEITKYGSLTENVSR-KYTKQMLEGLAYLHKNVIVHRDIKGANILRDGNGNIKLGDFGASKRLQTIVSATGL-HSVVGTPYWMAPEVINGEGYGRKADIWSVGCTIVEMLTTKPPWAEFESMAALYKIAMEKRPHFT-LPNHISELCHDVLSKAFDRNPSTRPTAIDLL 318
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0BQX0 (Protein kinase domain-containing protein OS=Paramecium tetraurelia OX=5888 GN=GSPATT00031166001 PE=3 SV=1) HSP 1 Score: 146.362 bits (368), Expect = 9.838e-34 Identity = 97/256 (37.89%), Postives = 146/256 (57.03%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFI-----NKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK-KLEKLEN--SVTPQMSKLLDLTKVPKEMVT-----FLEYMLDKDPKRRWTAEALLK 1559
G IG G FG V V+G++ AVK +FI NKV + ++ I + L H I++YYG+ + +L I +EYV GS+ I + ++ V Y KQIL GL++LH G+IHRD+K NIL++ VKLADFG G+ L + I ++ +L G+ F APE+ QYG DIWSLG T++ M TG +++N ++ ++SKL D+ +P+E+ + FL+ L +P+ RW AE LL+
Sbjct: 63 GEMIGQGAFGRVILGMNRVSGQIMAVKQVFIKSGDENKVQSIQREIEILS---KLQHLHIVRYYGSERKKDQLNIFLEYVSGGSVLMMIKRFGKFKESLIKV-YLKQILLGLQYLHSQGVIHRDIKGANILINQNGQVKLADFGSGKQLSE-IQQDVVG-SLCGTPNFMAPEVINQQQYGKKADIWSLGCTMIEMATGHPPFSEVKNIYTIMVKISKLTDMIPIPEELKSEQARDFLKKCLQLNPEDRWEAEDLLQ 312
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0G4FXQ4 (Protein kinase domain-containing protein OS=Vitrella brassicaformis (strain CCMP3155) OX=1169540 GN=Vbra_6072 PE=4 SV=1) HSP 1 Score: 149.443 bits (376), Expect = 3.188e-33 Identity = 96/268 (35.82%), Postives = 155/268 (57.84%), Query Frame = 3
Query: 801 TSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVK---TMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLLDLTKVP------KEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
+SI+ ++ G IG G FG V+K ++ TG AVK T ++K +SL++ I+ + LNH I+KY+ ++T+ T LYIV+EYV +GSL I K + M+ + Y+ Q+L G+ +LH+ G++HRD+K NIL VKLADFG+ R L + ++ ++ G+ Y+ APEI + T DIWS+G TV+ MLTGK + + P + +++ + P E+ +FL +K+P++R TA L++ E R+
Sbjct: 2 SSIKIGRYQLGEAIGKGGFGVVFKALDTKTGEFVAVKQVPTHNLSKEKLDSLRMEISLLRR-LNHRNIVKYHDSLTDGTFLYIVLEYVESGSLASIIKKYGSFMETLAAI-YTSQVLRGMRYLHEQGVVHRDIKGANILTTKRGIVKLADFGVARSLSEAEKTS----SVVGTPYWMAPEIIEMHVTSTACDIWSVGCTVIEMLTGKP-PYFDLAPMPALFRIVQDPRPPLPHDISPELQSFLMACFEKNPEKRITAAELMEHEWIRH 262
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 132.109 bits (331), Expect = 9.395e-32 Identity = 78/206 (37.86%), Postives = 118/206 (57.28%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAES------LKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E+ L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G+ YG D+WSLG TV+ MLT K
Sbjct: 355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEK 558
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 132.109 bits (331), Expect = 9.395e-32 Identity = 78/206 (37.86%), Postives = 118/206 (57.28%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAES------LKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E+ L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G+ YG D+WSLG TV+ MLT K
Sbjct: 355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEK 558
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596]) HSP 1 Score: 132.109 bits (331), Expect = 9.395e-32 Identity = 78/206 (37.86%), Postives = 118/206 (57.28%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAES------LKVNINAFQNILNHERIIKYYGAITE--DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E+ L+ I +N L+HERI++YYG + + + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S+ ++ G+ Y+ +PE+ +G+ YG D+WSLG TV+ MLT K
Sbjct: 355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKEVSTLECEIQLLKN-LHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGDGYGRKADVWSLGCTVVEMLTEK 558
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:103026704]) HSP 1 Score: 128.257 bits (321), Expect = 2.113e-30 Identity = 78/200 (39.00%), Postives = 115/200 (57.50%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLT 1406
G +G G FG V+ ++ TGR AVK + + + E +L+ I +N+ HERI++YYG + T + L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG R L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT
Sbjct: 362 GKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLF-HERIVQYYGCLRDTHERTLSIFMEYMPGGSIKDQLKSYGALTENVTR-KYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLT 559
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968]) HSP 1 Score: 124.405 bits (311), Expect = 3.705e-29 Identity = 78/207 (37.68%), Postives = 116/207 (56.04%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFIN--------KVNAESLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG+VY ++ TGR AVK + + +VNA L+ I +N L HERI++YYG + E KL I +E++ GS++D++ + RY++QIL+G+ +LH N I+HRD+K NIL D NVKL DFG + + S T+ G+ Y+ +PE+ G YG D+WS+ TV+ MLT K
Sbjct: 354 WRQGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKEVNA--LECEIQLLKN-LRHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTR-RYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKTVTGTPYWMSPEVINGEGYGRKADVWSVACTVVEMLTQK 556
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96]) HSP 1 Score: 131.724 bits (330), Expect = 3.287e-32 Identity = 89/263 (33.84%), Postives = 136/263 (51.71%), Query Frame = 3
Query: 651 GLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKV-FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQ------NILNHERIIKYYGAITEDTK--LYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +P+D++ IF E R+L +G + ++ D S R ++ G +G G FG VY ++ TGR AVK + + + E+ K +NA + L HERI++Y+G + + + L I MEY+ GS++D++ +N +Y++QILEG+ LH N I+HRD+K NIL D NVKL DFG + L ++ G+ Y+ +PE+ G YG DIWS+G TV+ MLT K
Sbjct: 302 GCSPTDVSLSTSSG-SSGIFTPEPDEGRARRLAGGVGGELAENADVSPPSRSPRAPTNWQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSK-EVNALECEIQLLKNLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGALTENVTR-KYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEVINGEGYGRKADIWSVGCTVVEMLTEK 561
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 109.383 bits (272), Expect = 1.396e-26 Identity = 86/296 (29.05%), Postives = 133/296 (44.93%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNI-----LNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSE----YFTAPEIGTG-NQYGTPVDIWSLGATVLFMLTGKKLEKLENSV-----------TPQMSKLLDLTKVPKEMVTF----------------------LEYMLDKDPKRRWTAEALLKLEMFRN 1577
+F+ KIG GT+G VYK + +TG A+K + +++ E+ V A + I LNH I++ I +TKLY+V E++ + N + + Y Q+L+G+ H +HRDLKP N+L++ + +KLADFG+ R +P+ E ++ APEI G Y T VD+WSLG MLT + L ++ + TP + +T++P +F L ML DP RR +A+A L F N
Sbjct: 3 LFQKVEKIGEGTYGVVYKARHKMTGDTVALKKI---RLDTETEGVPSTAIREIALLRELNHPNIVRLLDVIHSETKLYLVFEFLDQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAIKLADFGLARAFG-------VPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTPDETVWQGITQLPDYKPSFPRWCAQDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHN 288
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69]) HSP 1 Score: 114.005 bits (284), Expect = 1.632e-26 Identity = 80/262 (30.53%), Postives = 130/262 (49.62%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
E KIG G+ G V + +GR AVK M + K L N +HE ++ Y + +L++VME++ G+L D + + + + V S +L L +LH G+IHRD+K +ILL + +KL+DFG + K + +L G+ Y+ APE+ + YG VD+WSLG V+ M+ G + + ++ ++V P+M ++ K + FL+ ML +DP R TA LL+ +N
Sbjct: 419 LENFIKIGEGSTGVVCLAVDRRSGRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVADELWVVMEFLEGGALTDIVTHTRMNEEQIATVCVS--VLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGFCAQVSKEVTRR---KSLVGTPYWMAPEVISRLPYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMK---NIQKASPLLRGFLDQMLVRDPALRATALELLQHPFLQN 672
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865]) HSP 1 Score: 111.694 bits (278), Expect = 1.621e-25 Identity = 79/257 (30.74%), Postives = 123/257 (47.86%), Query Frame = 3
Query: 822 FEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ---YGTPVDIWSLGATV---------LFMLTGKKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALL 1556
FE ++G GT+GDV+K + TG L A+K + + + S+ H I+ YYG+ KL+I ME+ GSL+D + + +++ L+GL +LH G +HRD+K NILL + +VKLADFG+ + I + G+ Y+ APE+ + Y D+W++G T +F L + L + Q KL D K F++ L K+PK+R TAE +L
Sbjct: 14 FELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPLTERQIAY-VTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITATIAKR---KSFIGTPYWMAPEVAAVERKGGYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKML 266
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897]) HSP 1 Score: 108.612 bits (270), Expect = 1.052e-24 Identity = 79/253 (31.23%), Postives = 130/253 (51.38%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQ--NILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTP-VDIWSLGATVLFMLT------GKKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDK----DPKRRWTAEALLK 1559
IG G F V + ++TGR AVK + ++N SL+ + ILNH I+K + I + LY+VMEY G + D + + + ++ +QI+ +++ H+ I+HRDLK N+LLD + N+K+ADFG +GS + T GS + APE+ G +Y P VD+WSLG + +++ G+ L++L V L ++P M T E +L + +P +R + E ++K
Sbjct: 60 IGKGNFAKVKLARHTLTGREVAVKIIDKTQLNPSSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF-RQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFT--LGSKLD--TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERV------LRGKYRIPFYMSTDCENLLKRFLVLNPAKRGSLEQIMK 301
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 126.331 bits (316), Expect = 2.679e-30 Identity = 75/190 (39.47%), Postives = 110/190 (57.89%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVK-TMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLT 1406
IG G++G VYK T ++ A+K ++ N + I+ +N LNH I+KY+G I + +LYI++EY NGSL I++ + ++ Y Q L GL++LH G+IHRD+K NILL ++ VKLADFG+ +++ +TL G+ + APEI T DIWSLGATV+ MLT
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKN-LNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSS------ALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLT 213
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 123.25 bits (308), Expect = 2.731e-29 Identity = 85/255 (33.33%), Postives = 139/255 (54.51%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVN--AESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPE-IGTGNQYGTPVDIWSLGATVLFMLTG-------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFR 1574
IG G FG VYK TGR++A+K + ++ + E ++ I ++ I +YYG+ +DT L+I+ME+ GSL + K D K ++ +++L L+ +HK+ +IHRD+K N+L+ E NVKL DFG+ +++ +++ T+ G+ Y+ APE I G Y T VDIWSLG T + TG + L ++ + + +L D + + F+ LD+DPK R +A+ LLK + R
Sbjct: 29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIM--RELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQ---TSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFIR 277
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061]) HSP 1 Score: 107.457 bits (267), Expect = 6.650e-25 Identity = 77/263 (29.28%), Postives = 123/263 (46.77%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNIN--AFQNILNHERIIKYYGAITED--TKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXV---RYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK---KLEKLENSVTPQMSKLLDLTKVP-------------KEMVTFLEYMLDKDPKRRWTAEALLK 1559
+G G G V K + ++FA+KT+ + E K F + I++YYG T++ + +YI MEY+ SLE + ++ +L GL +LH+ +IHRD+KP NILL+ + +KL DFG+ G + MT G+ ++ APE G Y D+WSLG T+L + G+ + +K+ +V P + LT P K +F++Y L KD + R + +LK
Sbjct: 220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVS-----GEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLK 477
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: RAD53 (DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant [Source:SGD;Acc:S000006074]) HSP 1 Score: 107.842 bits (268), Expect = 1.336e-24 Identity = 87/267 (32.58%), Postives = 127/267 (47.57%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKV--NAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDN--VKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTG-------------NQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSK-----------LLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALL 1556
+G G F V K E TG+ FAVK + KV N + + + Q LNH RI++ G + Y+VME+V G L + D S+QIL ++++H GI HRDLKP NIL++ +D VK+ DFG+ +V +G GS + T G+ + APE+ G N+Y + VD+WS+G V +LTG S Q+ K L D ++ +E F++ +L DP R TA L
Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQK-LNHPRIVRLKGFYEDTESYYMVMEFVSGGDL-MDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKV--QGNGSFM--KTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHL--PFSGSTQDQLYKQIGRGSYHEGPLKDF-RISEEARDFIDSLLQVDPNNRSTAAKAL 461
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 107.071 bits (266), Expect = 3.708e-24 Identity = 86/264 (32.58%), Postives = 134/264 (50.76%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNA---------ESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPE-IGTGNQYGTPVDIWSLGATVLFMLTGKK-LEKLENSVTPQMSKL---LDLTKVPKEMV--------TFLEYMLDKDPKRRWTAEALL 1556
G IG G+FG VY TG + AVK + + K ++ E+L+ ++ ++ L+H I++Y G ++ + +EYV GS+ I + + Q+L+GL +LH GI+HRD+K N+LLD + K++DFGI R K I S MT++G+ ++ APE + T Y VDIWSLG VL M GK+ LE V M K+ +P++ + FL+ + +P++R TA LL
Sbjct: 1178 GEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKD-LDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIK-HLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK-SKDIYSNSD-MTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLE--VVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELL 1435
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7]) HSP 1 Score: 136.346 bits (342), Expect = 7.367e-36 Identity = 96/266 (36.09%), Postives = 137/266 (51.50%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINA------FQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK-KLEKLENSVTPQMSKLLDLTKVPKE----------MVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
G +G G FG VY + TGR AVK + ++N+ S K + A F +ERI++YYG T+D +YI MEY+ GS+ + I + ++ +YS+QILEG+ +LH N I+HRD+K NIL D NVKLADFG + L + I S ++ G+ Y+ APE+ G YG D+WS+G TV+ MLT K E M+ L + P E V F+ L + K R +A+ LL+ N
Sbjct: 7 GKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNS-STKNEVKALEGEIEFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTR-KYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRL-QTIRSKTGFRSVHGTPYWMAPEVINGEGYGRKADVWSVGCTVVEMLTTKPPWADFE-----PMAALFKIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVTN 264
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO49138 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH03]) HSP 1 Score: 118.627 bits (296), Expect = 8.566e-30 Identity = 81/247 (32.79%), Postives = 126/247 (51.01%), Query Frame = 3
Query: 840 IGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQ--NILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLL--DLTKVPKEMVTFLE----YMLDKDPKRRWTAEALL 1556
IG GTFG + + + RL+A+K + + +E + +N + + L H I++Y A E + YIVMEY G L KI + ++ I+ + Q+L L+H+H I+HRDLK NI L +D VK+ DFGI R+LD T G+ Y+ +PEI Y DIW+LG VL+ LT + +++T + K+L + +P+ LE ML +P R +A+ L+
Sbjct: 10 IGKGTFGSAWLVESRQSKRLYALKELNATAMPSEDRHLALNEVKILSTLKHRNIVRYRDAFEETGRFYIVMEYAEGGDLHTKIKQAVEPFSSERILNWLAQLLLALKHIHGQNILHRDLKTQNIFLTKDDVVKIGDFGIARILDSTCDHA---RTTVGTPYYLSPEICQRQPYNNKSDIWALGC-VLYELTTRTHPFTADNLTNLVVKILHGNYPPIPRFYGPLLEDLVAVMLKINPADRPSAKQLI 252
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO40961 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5T6]) HSP 1 Score: 118.242 bits (295), Expect = 3.269e-29 Identity = 71/206 (34.47%), Postives = 113/206 (54.85%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFM 1400
+F+ +G+GT+G V+K + TG+L A+K M + + E +K+ IN + NH I YYGA +D +L++VME+ GS+ D + +N ++ + Y +++L G+ HLH N +IHRD+K N+LL VKL DFG+ LD+ IG T G+ Y+ APE+ ++ Y D+WS+G T + M
Sbjct: 19 IFDLVEVVGNGTYGQVHKGRHKRTGQLTAIKIMDVTEDEEEEIKLEINVLRKFSNHRNIATYYGAFIKKSLQGQDDQLWLVMEFCGAGSVTDLVKTARNKALKEEWISYICREVLNGVSHLHMNHVIHRDIKGQNVLLTESAEVKLVDFGVSAQLDRTIGRR---NTFIGTPYWMAPEVIACDEQPDATYDNRCDMWSIGITAIEM 221
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0]) HSP 1 Score: 118.242 bits (295), Expect = 4.680e-28 Identity = 89/264 (33.71%), Postives = 130/264 (49.24%), Query Frame = 3
Query: 813 KKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIP-----MTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSV----------TPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLK 1559
KK + KIG G G VY E TG A+K M +++ + L +N H I+ Y + +L++VMEY+ GSL D + + D V ++ L+ LE LH NG+IHRD+K NILL + VKL DF G +TI P T+ G+ Y+ APE+ T QYG VD+WSLG + M+ G+ EN + TP+++ L+ V K+ FL L+ D ++R +A LL+
Sbjct: 223 KKKYTKFEKIGQGASGTVYTAIEVATGHEVAIKQMNLSQQPKKELIINEILVMRENKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDVVTETCMDEGQIAAV--CRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDF--------GFCATITPEQNKRSTMVGTPYWMAPEVVTRKQYGPRVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKD---FLAQSLEMDVEKRSSARELLQ 473
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO45846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL1]) HSP 1 Score: 112.849 bits (281), Expect = 1.512e-27 Identity = 85/255 (33.33%), Postives = 123/255 (48.24%), Query Frame = 3
Query: 837 KIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLLDL--------TKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
KIG G+ G V + TGR AVK M + K L N H I++ YG+ +L++VME++ G+L D + + V + +L+ L LH G+IHRD+K +ILL VKL+DFG + + + +L G+ Y+ APE+ + YGT VDIWSLG VL M+ G+ E + M KL DL ++ + +FL+ L +DP R TA LL RN
Sbjct: 34 KIGEGSTGIVCLATDKRTGRQVAVKKMDLKKQQRRELLFNEVVIMRDYPHPNIVEMYGSHLVGDELWVVMEFLEGGTLTDIVTHTNLSEEQVACV--CRAVLKALTFLHSQGVIHRDIKSDSILLTSNGTVKLSDFGFCAQVTEDMPRR---KSLVGTPYWMAPEVISRKPYGTEVDIWSLGIMVLEMVDGEPPYFNEPPLQ-AMRKLRDLEPPTSRNPIQISPRLQSFLDNALIRDPLYRATAFELLNHPFIRN 282
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290]) HSP 1 Score: 128.257 bits (321), Expect = 1.901e-30 Identity = 78/206 (37.86%), Postives = 117/206 (56.80%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAITEDTK--LYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
+ G +G G FG VY + TGR A K + + + E +L+ I +N L+HERI++YYG + + ++ L I MEY+ GS++D++ +N +Y++QILEG+ +LH N I+HRD+K NIL D NVKL DFG + L S ++ G+ Y+ +PE+ +G YG D+WSLG TV+ MLT K
Sbjct: 352 TWRRGKLLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKN-LHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAYGALTENVTR-KYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEK 555
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297]) HSP 1 Score: 127.872 bits (320), Expect = 2.628e-30 Identity = 80/202 (39.60%), Postives = 116/202 (57.43%), Query Frame = 3
Query: 831 GTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAE------SLKVNINAFQNILNHERIIKYYGAI--TEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTGK 1412
G +G G FG VY ++ TGR AVK + + + E +L+ I +N L HERI++YYG + T + L I ME++ GS++D++ +N RY++QILEG+ +LH N I+HRD+K NIL D NVKL DFG R L S ++ G+ Y+ +PE+ +G YG DIWS+G TV+ MLT +
Sbjct: 392 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKN-LCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTR-RYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQR 591
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: tnika (TRAF2 and NCK-interacting protein kinase [Source:NCBI gene;Acc:101155647]) HSP 1 Score: 126.331 bits (316), Expect = 2.061e-29 Identity = 89/274 (32.48%), Postives = 136/274 (49.64%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEI-----GTGNQYGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFR 1574
+FE +G+GT+G VYK + TG+L A+K M + E +K IN + N+ I YYGA + D +L++VME+ GS+ D I K + ++ Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LD+ +G T G+ Y+ APE+ Y D+WSLG T + M G + L + + P+ L K +++ +F+E+ L K+P +R E L K R
Sbjct: 24 IFEVVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSNNRNIATYYGAFIKKNPPGIDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTSYICREILRGLAHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGKR---NTFIGTPYWMAPEVIACDENPAATYDFKSDVWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPR----LKSKKWSRKLQSFIEFCLVKNPGQRPNTEELSKHAFIR 290
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: tnika (TRAF2 and NCK-interacting protein kinase [Source:NCBI gene;Acc:101155647]) HSP 1 Score: 125.561 bits (314), Expect = 3.968e-29 Identity = 89/274 (32.48%), Postives = 136/274 (49.64%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITE------DTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEI-----GTGNQYGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFR 1574
+FE +G+GT+G VYK + TG+L A+K M + E +K IN + N+ I YYGA + D +L++VME+ GS+ D I K + ++ Y ++IL GL HLH++ +IHRD+K N+LL VKL DFG+ LD+ +G T G+ Y+ APE+ Y D+WSLG T + M G + L + + P+ L K +++ +F+E+ L K+P +R E L K R
Sbjct: 27 IFEVVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKAEINMLKKYSNNRNIATYYGAFIKKNPPGIDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTSYICREILRGLAHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGKR---NTFIGTPYWMAPEVIACDENPAATYDFKSDVWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPR----LKSKKWSRKLQSFIEFCLVKNPGQRPNTEELSKHAFIR 293
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000011250.2 (mitogen-activated protein kinase kinase kinase kinase 4 [Source:NCBI gene;Acc:101156098]) HSP 1 Score: 125.176 bits (313), Expect = 6.212e-29 Identity = 91/275 (33.09%), Postives = 141/275 (51.27%), Query Frame = 3
Query: 819 VFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAIT------EDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRY-SKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQ-----YGTPVDIWSLGATVLFMLTG----------KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
+FE +G+GT+G VYK + TG+L A+K M + + E +K+ IN ++ +H I YYGA +D +L++VMEY GS+ D + K K + +D + Y +++L GL HLH + +IHRD+K N+LL VKL DFG+ LDK IG T G+ Y+ APE+ ++ Y D+WSLG T L M G + L + + P++ K K ++F++ L K+ R +ALL+ R+
Sbjct: 24 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMEVTEEEEEEIKLEINMLKSYSHHRNIATYYGAFVKKSPAGQDHQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLSHLHSHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDKTIGRR---NTFIGTPYWMAPEVIACDENPEATYDYRSDLWSLGITALEMAEGAPPLCDMHPMRALFLIPRNPPPKLKS----KKWSKRFLSFVDSCLVKNHLHRPATDALLRHAFIRD 291
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017248.1 (SMESG000017248.1) HSP 1 Score: 817.379 bits (2110), Expect = 0.000e+0 Identity = 418/495 (84.44%), Postives = 451/495 (91.11%), Query Frame = 3
Query: 96 MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTG-KKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
M+EF++F++ +KLGN ESF +LYKP+YLNKKD Q W AIHYAC + +LE LIS NC+INQ GG++G+ PIQ+AC IV +LT+AECDI+ + + ++K +E I++ILK RKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHK CPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEDKINKKKNDMKNDDIVRYSKQ+LEGLEHLHK GIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLT + ++ L++ VTPQMS+LLD+ KVPKEMVTFLEYML KDPKRRWTAEALLKLEMFRN
Sbjct: 1 MSEFQAFVDAIKLGNLESFVQLYKPDYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIDIKCLENSLMKC----PNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKLCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEDKINKKKNDMKNDDIVRYSKQVLEGLEHLHKIGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTGNQYGTPVDIWSLGATVLFMLTDIENVKGLKDLVTPQMSELLDINKVPKEMVTFLEYMLVKDPKRRWTAEALLKLEMFRN 491
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017245.1 (SMESG000017245.1) HSP 1 Score: 763.066 bits (1969), Expect = 0.000e+0 Identity = 396/501 (79.04%), Postives = 430/501 (85.83%), Query Frame = 3
Query: 96 MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKC-SDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXX----VRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGTG--NQYGTPVDIWSLGATVLFMLTGKKLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMFRN 1577
MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILE+LISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLL CDID DKA AP DIA++ + +LIK+ +E ERPLR+LISSMGV C DTCDHKFC +IR K F GG +IGHG++G VYKFQES T R+FAVKT+ +K N S++ +IN FQ+ LNHERIIKYYGA+++ T+ YI+MEY +NGSL DK+NKKKNDMKND VRYSKQILEGLEHLHK GIIHRDLKPGNILLDGEDNVKLADFGIGRVL++ G M + G+ F A E+ N YG P DIWSLGATVLFML + LEKL+NSVTPQMS+LLDLTKVPKEMVTFLEYML KDPKRRWTAEALLKLEMFRN
Sbjct: 1 MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILENLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLAHNCDIDALDKANQAPEDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCSKTIRNKSFNGGKEIGHGSYGTVYKFQESGTERMFAVKTITNSKAN--SIEADINKFQHRLNHERIIKYYGAVSDGTQQYIIMEYAINGSLADKMNKKKNDMKNDMKNDDIVRYSKQILEGLEHLHKIGIIHRDLKPGNILLDGEDNVKLADFGIGRVLERETGKDFT-MNM-GTPGFIAYEVQHKDENGYGPPADIWSLGATVLFMLDIENLEKLKNSVTPQMSELLDLTKVPKEMVTFLEYMLVKDPKRRWTAEALLKLEMFRN 497
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017248.1 (SMESG000017248.1) HSP 1 Score: 539.65 bits (1389), Expect = 0.000e+0 Identity = 261/322 (81.06%), Postives = 286/322 (88.82%), Query Frame = 3
Query: 96 MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVN 1061
M+EF++F++ +KLGN ESF +LYKP+YLNKKD Q W AIHYAC + +LE LIS NC+INQ GG++G+ PIQ+AC IV +LT+AECDI+ + + ++K +E I++ILK RKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHK CPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVN
Sbjct: 1 MSEFQAFVDAIKLGNLESFVQLYKPDYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIDIKCLENSLMKC----PNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKLCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVN 318
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017030.1 (SMESG000017030.1) HSP 1 Score: 350.903 bits (899), Expect = 2.356e-110 Identity = 201/466 (43.13%), Postives = 286/466 (61.37%), Query Frame = 3
Query: 210 IHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIE-FEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGT----GNQYGTPVDIWSLGATVLFMLTGK-------KLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMF 1571
IH AC++ + ++ LI C+I ++ RPI +ACY H V++LT +CDIE + + + ++I EK ++ II IL + LLACK GDL+ V ++ +E CDK+ RRPIHWA E G+ EIVKLL+E+ CD+ +DK ++P DIA + +L++I L L LIS MG+KC CDHKFC TS+R K F G+ IG+G FGD+YK + S +FA+K + + K+ +S++ NIN F + LNH+RIIKY+GAI L I MEY+ GSLED+I K+K + ++ ++YSKQILEGLE LH + IIHRD+KP NILL E+N+KLADFGI R L + G + ++ G+ FTAPE+ Y DIWS+GATV+ M+ G+ L + T + + + +EM F+E ML+ DP +R TA LLKL++F
Sbjct: 230 IHLACYQGRSEAVKLLIDHKCDIEALDWRN-RRPIHLACYHGHSEAVKLLTEHKCDIEALDEDGNSAVEIAEKSGNKIIIRILNEARLLLACKNGDLKNVSKLVNGSTIECCDKNKRRPIHWACESGNIEIVKLLIERKCDLTARDKCEMSPLDIAVKNENKELVEI----LKAEELELLISKMGLKCKLFCDHKFCNTSLRNKTFVKGSHIGNGAFGDIYKCKGSGIDAVFAIKWIELKKIGEKSIEGNINQFLHKLNHKRIIKYFGAIQAKDHLCIFMEYLSKGSLEDEIIKRKRPIDTENTIKYSKQILEGLEFLHSHRIIHRDIKPANILLSDENNIKLADFGISRSLMRTDGKSTKAVSGVGTFNFTAPEVIRIEIDNAPYTESADIWSVGATVINMIEGRPPYDYCDPLALIFKIATDKKLVMPHSQMMSEEMKAFIEEMLNPDPNKRPTAAQLLKLKLF 690 HSP 2 Score: 115.931 bits (289), Expect = 1.600e-26 Identity = 65/207 (31.40%), Postives = 106/207 (51.21%), Query Frame = 3
Query: 102 EFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTD-VNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEEN 719
EFE F++ ++ G+ E F++ +K E+L ++D GW IH+AC+ ++ LI N RPI +ACY H +++L +CDIE ++ R LAC G E V+ ++ ++E D+DN RPIH+A GH+E +KLL+E C+I+ DK P A +K++++ IK+ E+
Sbjct: 4 EFELFIDAIRSGSAELFDRYFKAEFLEREDANGWRPIHHACYHGNSEAVKLLIEHKWN---------QRPIHLACYHGHSEAIKLLIEHKCDIE-------------------ALDWWNQRPIHLACNHGHSEAVKLLIEHKCDIEALDEDNWRPIHYACNHGHSEAIKLLIEHECNIEALDKWNQRPIHYAINKRHSEAIKLLIEH 182
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017030.1 (SMESG000017030.1) HSP 1 Score: 350.517 bits (898), Expect = 3.759e-110 Identity = 201/466 (43.13%), Postives = 286/466 (61.37%), Query Frame = 3
Query: 210 IHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIE-FEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKCSDTCDHKFCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEXXXXXXXXXXXXXXXVRYSKQILEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEIGT----GNQYGTPVDIWSLGATVLFMLTGK-------KLEKLENSVTPQMSKLLDLTKVPKEMVTFLEYMLDKDPKRRWTAEALLKLEMF 1571
IH AC++ + ++ LI C+I ++ RPI +ACY H V++LT +CDIE + + + ++I EK ++ II IL + LLACK GDL+ V ++ +E CDK+ RRPIHWA E G+ EIVKLL+E+ CD+ +DK ++P DIA + +L++I L L LIS MG+KC CDHKFC TS+R K F G+ IG+G FGD+YK + S +FA+K + + K+ +S++ NIN F + LNH+RIIKY+GAI L I MEY+ GSLED+I K+K + ++ ++YSKQILEGLE LH + IIHRD+KP NILL E+N+KLADFGI R L + G + ++ G+ FTAPE+ Y DIWS+GATV+ M+ G+ L + T + + + +EM F+E ML+ DP +R TA LLKL++F
Sbjct: 235 IHLACYQGRSEAVKLLIDHKCDIEALDWRN-RRPIHLACYHGHSEAVKLLTEHKCDIEALDEDGNSAVEIAEKSGNKIIIRILNEARLLLACKNGDLKNVSKLVNGSTIECCDKNKRRPIHWACESGNIEIVKLLIERKCDLTARDKCEMSPLDIAVKNENKELVEI----LKAEELELLISKMGLKCKLFCDHKFCNTSLRNKTFVKGSHIGNGAFGDIYKCKGSGIDAVFAIKWIELKKIGEKSIEGNINQFLHKLNHKRIIKYFGAIQAKDHLCIFMEYLSKGSLEDEIIKRKRPIDTENTIKYSKQILEGLEFLHSHRIIHRDIKPANILLSDENNIKLADFGISRSLMRTDGKSTKAVSGVGTFNFTAPEVIRIEIDNAPYTESADIWSVGATVINMIEGRPPYDYCDPLALIFKIATDKKLVMPHSQMMSEEMKAFIEEMLNPDPNKRPTAAQLLKLKLF 695 HSP 2 Score: 120.553 bits (301), Expect = 5.933e-28 Identity = 66/207 (31.88%), Postives = 109/207 (52.66%), Query Frame = 3
Query: 102 EFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTD-VNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEEN 719
EFE F++ ++ G+ E F++ +K E+L ++D GW IH+AC+ ++ LI C+I +RPI +ACY H +++L +CDIE ++ R LAC G E V+ ++ ++E D+DN RPIH+A GH+E +KLL+E C+I+ DK P A +K++++ IK+ E+
Sbjct: 4 EFELFIDAIRSGSAELFDRYFKAEFLEREDANGWRPIHHACYHGNSEAVKLLIEHKCDIEA----LDIRPIHLACYHGHSEAIKLLIEHKCDIE-------------------ALDWWNQRPIHLACNHGHSEAVKLLIEHKCDIEALDEDNWRPIHYACNHGHSEAIKLLIEHECNIEALDKWNQRPIHYAINKRHSEAIKLLIEH 187 HSP 3 Score: 75.8702 bits (185), Expect = 6.967e-14 Identity = 51/178 (28.65%), Postives = 80/178 (44.94%), Query Frame = 3
Query: 189 DDQGWYAIHYACHEDQQAILEHLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTD-VNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEEN 719
D+ W IHYAC+ ++ LI CNI + + RPI A H +++L EC+IE ++ R LAC G E V+ ++ ++E D N+RPIH A G +E VKLL++ CDI+ D P +A +++ +K+ E+
Sbjct: 129 DEDNWRPIHYACNHGHSEAIKLLIEHECNI-EALDKWNQRPIHYAINKRHSEAIKLLIEHECNIE-------------------ALDGANWRPIHLACNHGHSEAVKLLIEHKCDIEALDWWNQRPIHLACYQGRSEAVKLLIDHKCDIEALDWRNRRPIHLACYHGHSEAVKLLTEH 286 The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021070 ID=SMED30021070|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2244bpback to top protein sequence of SMED30021070-orf-1 >SMED30021070-orf-1 ID=SMED30021070-orf-1|Name=SMED30021070-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=495bp MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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