Lysine-specific histone demethylase 1A
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021069 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 1
Homology
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Match: KDM1A (lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079]) HSP 1 Score: 272.707 bits (696), Expect = 2.962e-77 Identity = 213/822 (25.91%), Postives = 362/822 (44.04%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 183 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKRIKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 830
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Match: KDM1A (lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079]) HSP 1 Score: 272.322 bits (695), Expect = 4.602e-77 Identity = 217/824 (26.33%), Postives = 359/824 (43.57%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTS-----NEEEDTTDRVEPKRTTI-INPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ + I+K QE + E+ + + K+ + +E ++K +DI E +V + R T+ +E +T ++E K + NP + FF + + + I D W FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 183 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKRIKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKT----QEELKELLNKMVNLKEKIKELHQQYKEASEVKPP--------------RDITAE------FLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSPL------------------FFCSDVYLSSRDRQILD-----------------WHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 836
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Match: KDM1A (lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079]) HSP 1 Score: 266.929 bits (681), Expect = 4.908e-75 Identity = 213/826 (25.79%), Postives = 362/826 (43.83%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP----VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 203 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKRIKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 854
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Match: KDM1A (lysine demethylase 1A [Source:HGNC Symbol;Acc:HGNC:29079]) HSP 1 Score: 145.976 bits (367), Expect = 5.841e-38 Identity = 100/327 (30.58%), Postives = 156/327 (47.71%), Query Frame = 3
Query: 1806 SGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYS--------NEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
+GS + ++ G+ + L + I + NT V+++ Y+ + G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 5 TGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASVFSHPTSAGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 282
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Match: KDM1B (lysine demethylase 1B [Source:HGNC Symbol;Acc:HGNC:21577]) HSP 1 Score: 108.612 bits (270), Expect = 2.417e-23 Identity = 87/344 (25.29%), Postives = 158/344 (45.93%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGH--SNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
+NLE G++L+ +S R ++ +G + G+ ++ L + I Q + V+ I+YS + + +T D + A V+ T+PL +L++ A QF+PPL + K+K+IN+LG G+ +K+ L F RFW F + +RG F FY + ++ + ++ V+ G+A + + L D ++ ++ +A LR++F ++ VP+P+ +V RW+ DP+ + +S++ G S + +A + GTV FFAGE T+ T+ GA +SG++ AS I
Sbjct: 540 LSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDI-QLKSPVQCIDYSGDEVQVTTT-------DGTGYSAQKVLVTVPLALLQK--------GAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDM---------------------DPQKKHSVLMSVIAGEAVASV---RTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDI---------------QGTV-------FFAGEATNRHFPQTVTGAYLSGVREASKI 819
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Celegans
Match: lsd-1 (Lysine-Specific histone Demethylase homolog [Source:UniProtKB/TrEMBL;Acc:Q22343]) HSP 1 Score: 92.0485 bits (227), Expect = 1.091e-18 Identity = 81/307 (26.38%), Postives = 129/307 (42.02%), Query Frame = 3
Query: 1839 QALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLG-TNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTD---VEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDIC 2747
Q L++ ++ +N V EI+ + +I + + AD VVSTLP+GVLK++I +G AP F PPLP K +I +LG G+ +K+V F+ RFW S + FA + + +R + + + + T+Y + D E+ +AL L+ +F + P P YV W D A G +++ + + PL + R G P++FFAGEHT + GT+ GA SGL+AA+D+
Sbjct: 460 QVLINVANERKVKIHHNQRVIEIDTGSSDAVILKLRKP--DGSVGILNADYVVSTLPIGVLKKTI---IGDERAPVFRPPLPKSKFAAIRSLGNGLINKIVFVFETRFWPES-INQFAIVPDKISERAAMFTWSSLPESRTL--------------------------------TTHYVGENRFHDTPVTELITKALEMLKTVFK----DCPSPIDAYVTNWHTDELAFGTGTFMSLRTEPQHFDALKEPL-----------KTRDGK------PRVFFAGEHTSALEHGTLDGAFNSGLRAAADLA 707
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Celegans
Match: spr-5 (Probable lysine-specific histone demethylase 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XWP6]) HSP 1 Score: 80.4925 bits (197), Expect = 3.411e-15 Identity = 83/326 (25.46%), Postives = 133/326 (40.80%), Query Frame = 3
Query: 1782 CHDSNVDTSGSEIYIKKGFQALMSTLTKKSTI-FQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFW-GHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVG--VVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPE-PSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
C +G + +G L++ L++K + + V +I+YS G + D KA VVSTLP+GVLK++I AP F+P LPD K+++I +G G +K +L F FW + F + + RG + ++V G V+C + +L D + + A+ L+ F N P P ++ RW D A G +++ ++V PL + + +++FAGEHT S+ TIQGA MSG +AA+DI
Sbjct: 406 CDSMQNKENGVAARLTEGIAELLTQLSEKRKLDIRLKHRVLDIDYS--GFEHVLLKVQRENGDIEEMKAAFVVSTLPIGVLKKTI--IADERAPTFTPSLPDKKVEAIRNIGCGSVNKCILEFDRVFWTANGGRNQFVTVSPNIKTRGSM------------------------------NIWSSVPGSKVLCTYIVGEEAM-LELPDDVIIQNAMINLQKAFGN---NCPRAPISAHITRWHDDELAFGSGAFMSLRTETTSFDDVMEPLKTSD-----------------GMSRVYFAGEHTCSSYTSTIQGAWMSGARAAADI 676
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Celegans
Match: spr-5 (Probable lysine-specific histone demethylase 1 [Source:UniProtKB/Swiss-Prot;Acc:Q9XWP6]) HSP 1 Score: 80.4925 bits (197), Expect = 3.411e-15 Identity = 83/326 (25.46%), Postives = 133/326 (40.80%), Query Frame = 3
Query: 1782 CHDSNVDTSGSEIYIKKGFQALMSTLTKKSTI-FQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFW-GHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVG--VVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPE-PSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
C +G + +G L++ L++K + + V +I+YS G + D KA VVSTLP+GVLK++I AP F+P LPD K+++I +G G +K +L F FW + F + + RG + ++V G V+C + +L D + + A+ L+ F N P P ++ RW D A G +++ ++V PL + + +++FAGEHT S+ TIQGA MSG +AA+DI
Sbjct: 406 CDSMQNKENGVAARLTEGIAELLTQLSEKRKLDIRLKHRVLDIDYS--GFEHVLLKVQRENGDIEEMKAAFVVSTLPIGVLKKTI--IADERAPTFTPSLPDKKVEAIRNIGCGSVNKCILEFDRVFWTANGGRNQFVTVSPNIKTRGSM------------------------------NIWSSVPGSKVLCTYIVGEEAM-LELPDDVIIQNAMINLQKAFGN---NCPRAPISAHITRWHDDELAFGSGAFMSLRTETTSFDDVMEPLKTSD-----------------GMSRVYFAGEHTCSSYTSTIQGAWMSGARAAADI 676
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Celegans
Match: amx-1 (Amine oxidase family member 1 [Source:UniProtKB/Swiss-Prot;Acc:Q21988]) HSP 1 Score: 78.1814 bits (191), Expect = 2.085e-14 Identity = 94/351 (26.78%), Postives = 148/351 (42.17%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEG--IMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSN-----MKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
+ NLE GTH++NLS + ++ + +G I G Q ++ L I + N VK I++ + + I N + E+ D VV T L VLK + ++ F PPLP K K+I+ LG G+ +K+ + F RFW + + F ++ + R F FY FS KD + + T V ++ A + L LT+ E+ + A LR +F IN P + W D + ++++P G+ D T NQ ++ KL+FAGEHT +A T+ GA +SGL+ A I
Sbjct: 519 FHLGNLEFSCGTHVSNLSAKDYDHNEKFGNFAGEHAVITDGAQRIIDFLATGLDI-RLNCPVKCIDWGRDDRKVKIFFENAEQAAEE-----FDKVVITTSLSVLKSN-------HSKMFVPPLPIEKQKAIDDLGAGLIEKIAVKFDRRFWDTVDADGLRTEYFGKVSDCKTDRSLFNIFYDFSGKDPNG-------------------EDTFV-LMSYVTAEHVNLVNVLTESEVADKFCATLRKMFPSAVIN---PLGHMMSHWGADRFVGMSYTFVPFGSD-GDA-------------TYNQLKKSID-------EKLYFAGEHTIAAEPQTMAGAYISGLREAGQI 812 HSP 2 Score: 62.003 bits (149), Expect = 2.304e-9 Identity = 43/153 (28.10%), Postives = 73/153 (47.71%), Query Frame = 3
Query: 591 VDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITG-INNPVNQLIKQAGLGVSVMNSDVDIVNTTG 1046
V+ T+K + I++ + + L+H + FL G VN G F+ + + + G+ ++ +IGAG+SGI A L++ G ++ EAK+ GGR+ Q G I G INNP+ L +Q G+ N +++ G
Sbjct: 296 VELTVKMIEPQIIVRGHARIFFIEHLIHPILEFLTIKGVVNYGAFDFRIDPLN--------GMRPKIAIIGAGISGISTARHLKHLGIDAVLFEAKDRFGGRMMDDQSLGVSVGKGAQIIVGNINNPITLLCEQIGIKYRNSNFFCPLIDENG 440
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Match: Su(var)3-3 (gene:FBgn0260397 transcript:FBtr0074826) HSP 1 Score: 169.474 bits (428), Expect = 1.106e-42 Identity = 120/352 (34.09%), Postives = 176/352 (50.00%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLG--TNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIP-LPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
W FANLE T LNNLSL+H D + + G ++ G+ + LT+ I + N+ VKEI+Y +G+ + A N S + +KAD+VV TL LGVLK ++ + +N +F PPLPDWK ++I LGFG +KVVLCF FW N +F + + RGE F++ S ++ +V G AA L + +TD + R ++ L++IF +VP+P V RW DP+ARG +SY+ G+S +D + +A P +P D +P+LFFAGEHT T+ GA +SGL+ A I +Y
Sbjct: 524 WHFANLEFANATRLNNLSLKHWD-QDDDFEFIGHHTTVRNGYSCVPVALTENLDI-RVNSAVKEIKYGTKGVEVVAENLKTSNSQ-MTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFW-DPNANLFGHVGSTTASRGEMFLFWSISSS------------------------PVLLALVAGMAA---NLVESVTDDIIIGRCMSVLKNIF--GNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE-------------GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYL 829 HSP 2 Score: 117.087 bits (292), Expect = 2.659e-26 Identity = 77/236 (32.63%), Postives = 123/236 (52.12%), Query Frame = 3
Query: 651 DNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTL--------HCKNLKKSSNALI--LKLMNRLQEVINEMEQHKIAVSNAYK 1325
D+ LV FLERHG++N G F K+ + I L +V VIGAG+SG+ A QLQ FG V+VLEA++ GGR+ TF++ + A++ +TG+ NP+ L KQ G+ + + + G PV KE IE E NRLL +A+ + + N VSLG+ LE ++S+Q + H + + + +I + + L++ I +++ +A+ N K
Sbjct: 229 DSEPSLVRRVHSFLERHGFINFGIF-KRLKPIPAKKLG-------KVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRK 456
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Match: Su(var)3-3 (gene:FBgn0260397 transcript:FBtr0074825) HSP 1 Score: 169.474 bits (428), Expect = 1.106e-42 Identity = 120/352 (34.09%), Postives = 176/352 (50.00%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLG--TNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIP-LPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
W FANLE T LNNLSL+H D + + G ++ G+ + LT+ I + N+ VKEI+Y +G+ + A N S + +KAD+VV TL LGVLK ++ + +N +F PPLPDWK ++I LGFG +KVVLCF FW N +F + + RGE F++ S ++ +V G AA L + +TD + R ++ L++IF +VP+P V RW DP+ARG +SY+ G+S +D + +A P +P D +P+LFFAGEHT T+ GA +SGL+ A I +Y
Sbjct: 524 WHFANLEFANATRLNNLSLKHWD-QDDDFEFIGHHTTVRNGYSCVPVALTENLDI-RVNSAVKEIKYGTKGVEVVAENLKTSNSQ-MTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFW-DPNANLFGHVGSTTASRGEMFLFWSISSS------------------------PVLLALVAGMAA---NLVESVTDDIIIGRCMSVLKNIF--GNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE-------------GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYL 829 HSP 2 Score: 117.087 bits (292), Expect = 2.659e-26 Identity = 77/236 (32.63%), Postives = 123/236 (52.12%), Query Frame = 3
Query: 651 DNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTL--------HCKNLKKSSNALI--LKLMNRLQEVINEMEQHKIAVSNAYK 1325
D+ LV FLERHG++N G F K+ + I L +V VIGAG+SG+ A QLQ FG V+VLEA++ GGR+ TF++ + A++ +TG+ NP+ L KQ G+ + + + G PV KE IE E NRLL +A+ + + N VSLG+ LE ++S+Q + H + + + +I + + L++ I +++ +A+ N K
Sbjct: 229 DSEPSLVRRVHSFLERHGFINFGIF-KRLKPIPAKKLG-------KVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRK 456
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Match: Su(var)3-3 (gene:FBgn0260397 transcript:FBtr0332693) HSP 1 Score: 168.703 bits (426), Expect = 1.455e-42 Identity = 120/352 (34.09%), Postives = 176/352 (50.00%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLG--TNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIP-LPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
W FANLE T LNNLSL+H D + + G ++ G+ + LT+ I + N+ VKEI+Y +G+ + A N S + +KAD+VV TL LGVLK ++ + +N +F PPLPDWK ++I LGFG +KVVLCF FW N +F + + RGE F++ S ++ +V G AA L + +TD + R ++ L++IF +VP+P V RW DP+ARG +SY+ G+S +D + +A P +P D +P+LFFAGEHT T+ GA +SGL+ A I +Y
Sbjct: 504 WHFANLEFANATRLNNLSLKHWD-QDDDFEFIGHHTTVRNGYSCVPVALTENLDI-RVNSAVKEIKYGTKGVEVVAENLKTSNSQ-MTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFW-DPNANLFGHVGSTTASRGEMFLFWSISSS------------------------PVLLALVAGMAA---NLVESVTDDIIIGRCMSVLKNIF--GNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE-------------GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYL 809 HSP 2 Score: 101.679 bits (252), Expect = 1.406e-21 Identity = 62/191 (32.46%), Postives = 103/191 (53.93%), Query Frame = 3
Query: 786 QVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTL--------HCKNLKKSSNALI--LKLMNRLQEVINEMEQHKIAVSNAYK 1325
+V VIGAG+SG+ A QLQ FG V+VLEA++ GGR+ TF++ + A++ +TG+ NP+ L KQ G+ + + + G PV KE IE E NRLL +A+ + + N VSLG+ LE ++S+Q + H + + + +I + + L++ I +++ +A+ N K
Sbjct: 246 KVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRK 436
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Match: CG8032 (gene:FBgn0037606 transcript:FBtr0334318) HSP 1 Score: 84.7297 bits (208), Expect = 1.645e-16 Identity = 78/284 (27.46%), Postives = 116/284 (40.85%), Query Frame = 3
Query: 1938 AINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIF-------AQLKAQREQ--------RGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
A N + ED F A V+ T+PLGVLK T+ F P LP +K +SI L FG DK+ L ++ F +I + + E+ + F + Y+F+K D ++G V G+ A + L + ++ LR+ FL+ VP+P W + G ++ IP GA+ D+EN+A PL T Q P + FAGEHTHS+ T+ GA +SG AA +
Sbjct: 321 AGNVRIDCEDGRVFHAAHVICTIPLGVLK-------NTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKRDMNSSEEELASEAYLSKNWFKKIYSFAKV----------------------TDTLLLGWVSGREAEYM---EKLDHEAVAEKCTEILRN-FLQDPY-VPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPL---------------YATPQAMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHL 555
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Match: CG8032 (gene:FBgn0037606 transcript:FBtr0081880) HSP 1 Score: 84.7297 bits (208), Expect = 1.645e-16 Identity = 78/284 (27.46%), Postives = 116/284 (40.85%), Query Frame = 3
Query: 1938 AINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIF-------AQLKAQREQ--------RGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
A N + ED F A V+ T+PLGVLK T+ F P LP +K +SI L FG DK+ L ++ F +I + + E+ + F + Y+F+K D ++G V G+ A + L + ++ LR+ FL+ VP+P W + G ++ IP GA+ D+EN+A PL T Q P + FAGEHTHS+ T+ GA +SG AA +
Sbjct: 321 AGNVRIDCEDGRVFHAAHVICTIPLGVLK-------NTHRTLFDPVLPQYKQESIENLMFGTVDKIFLEYERPFLSADISEIMLLWDDDKRDMNSSEEELASEAYLSKNWFKKIYSFAKV----------------------TDTLLLGWVSGREAEYM---EKLDHEAVAEKCTEILRN-FLQDPY-VPKPKRCVCTSWKSQDFTGGAYTSIPVGATQEDIENLAQPL---------------YATPQAMKPAIVFAGEHTHSSFYSTVHGAYLSGRTAAQHL 555
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Match: kdm1a (lysine (K)-specific demethylase 1a [Source:ZFIN;Acc:ZDB-GENE-030131-7828]) HSP 1 Score: 283.878 bits (725), Expect = 2.400e-81 Identity = 225/821 (27.41%), Postives = 371/821 (45.19%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N ++ + ++LY+RN+ WL +PKVQLT ++ + + ++ DA+L VH +LERHG++N G + + T + +V VIGAG+SG+ AA QLQ FG V VLE+++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H W KK+ K ++ELKD+ N+ +V+T + +++ V+P R L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y++ G + A+NT S +K D V+ TLPLGV+K+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 188 LPHDRMTSQEAACFPDIINGPQHTQKVFLYIRNRTLQLWLDNPKVQLTFEATVQQLEAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGFINFGIYKRVKPLPTKKTG--------KVIVIGAGVSGLAAARQLQSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH----------W-------KKIVK----------TQEELKDLLNK-------MVTTKEKVKELHQQYKEASEVKPPRDITAE-------FLVKSKHRDLTALCKEYDELVEMQVKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTSSGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVMKQQ------PPAVQFVPPLPEWKTAAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 835
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Match: kdm1a (lysine (K)-specific demethylase 1a [Source:ZFIN;Acc:ZDB-GENE-030131-7828]) HSP 1 Score: 277.715 bits (709), Expect = 2.299e-79 Identity = 225/827 (27.21%), Postives = 371/827 (44.86%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP------VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N ++ + ++LY+RN+ WL +PKVQLT ++ + + ++ DA+L VH +LERHG++N G + + T + +V VIGAG+SG+ AA QLQ FG V VLE+++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H W KK+ K ++ELKD+ N+ +V+T + +++ V+P R L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y++ G + A+NT S +K D V+ TLPLGV+K+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 157 LPHDRMTSQEAACFPDIINGPQHTQKVFLYIRNRTLQLWLDNPKVQLTFEATVQQLEAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGFINFGIYKRVKPLPTKKTG--------KVIVIGAGVSGLAAARQLQSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH----------W-------KKIVK----------TQEELKDLLNK-------MVTTKEKVKELHQQYKEASEVKPPRDITAE-------FLVKSKHRDLTALCKEYDELVEMQVKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTSSGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVMKQQ------PPAVQFVPPLPEWKTAAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 810
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Match: kdm1a (lysine (K)-specific demethylase 1a [Source:ZFIN;Acc:ZDB-GENE-030131-7828]) HSP 1 Score: 112.464 bits (280), Expect = 1.168e-27 Identity = 66/186 (35.48%), Postives = 102/186 (54.84%), Query Frame = 3
Query: 666 LVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKN 1220
LVH +LERHG++N G + + T + +V VIGAG+SG+ AA QLQ FG V VLE+++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+
Sbjct: 5 LVHRIHSYLERHGFINFGIYKRVKPLPTKKTG--------KVIVIGAGVSGLAAARQLQSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD 182
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Match: zgc:66484 (zgc:66484 [Source:ZFIN;Acc:ZDB-GENE-030131-5768]) HSP 1 Score: 83.5741 bits (205), Expect = 3.991e-16 Identity = 84/319 (26.33%), Postives = 133/319 (41.69%), Query Frame = 3
Query: 1833 GFQALMSTLTKK--STIFQYNTVVKEIEYSNEGIMITAINTALSEEDPV--------FFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVEN-VAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
G+QA++ L + S + N VK I + + + E+ PV F+AD V+ T+ LGVLKE F P LP+ K+ +IN LGFG+ +K+ L F++ FW + K E + + D + + +G + + + G + G+ A + L D E+ + + LR VPE S + RW DP RG ++++P+G + +A PLP + RS G + V FAGE TH T GA +SG + A + +Y
Sbjct: 211 GYQAILDVLLRDVPSEAVRCNAPVKTIRWD-----LVKEGQSEEEDHPVQVVCENGQTFEADHVIVTVSLGVLKEHAKT-------MFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCAGVQLVWKEGPEDKD------VYEDLSEGEDWKQTWFKKITGFDTVARHPTALCGWITGREALYM---ESLQDREIQEVCVRLLRS---STGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEAHKALASPLP---------PKHRSRGRKNLQV---LFAGEATHVNFYTTTHGAYLSGQREAERLISYY 493
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Match: zgc:66484 (zgc:66484 [Source:ZFIN;Acc:ZDB-GENE-030131-5768]) HSP 1 Score: 83.5741 bits (205), Expect = 3.991e-16 Identity = 84/319 (26.33%), Postives = 133/319 (41.69%), Query Frame = 3
Query: 1833 GFQALMSTLTKK--STIFQYNTVVKEIEYSNEGIMITAINTALSEEDPV--------FFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVEN-VAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
G+QA++ L + S + N VK I + + + E+ PV F+AD V+ T+ LGVLKE F P LP+ K+ +IN LGFG+ +K+ L F++ FW + K E + + D + + +G + + + G + G+ A + L D E+ + + LR VPE S + RW DP RG ++++P+G + +A PLP + RS G + V FAGE TH T GA +SG + A + +Y
Sbjct: 211 GYQAILDVLLRDVPSEAVRCNAPVKTIRWD-----LVKEGQSEEEDHPVQVVCENGQTFEADHVIVTVSLGVLKEHAKT-------MFDPTLPEKKLSAINDLGFGIVNKIFLFFEKSFWPDDCAGVQLVWKEGPEDKD------VYEDLSEGEDWKQTWFKKITGFDTVARHPTALCGWITGREALYM---ESLQDREIQEVCVRLLRS---STGWPVPEVSKTLISRWGSDPQVRGSYTFVPDGVDGVEAHKALASPLP---------PKHRSRGRKNLQV---LFAGEATHVNFYTTTHGAYLSGQREAERLISYY 493
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Match: pcbd1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:Xenbase;Acc:XB-GENE-975699]) HSP 1 Score: 278.1 bits (710), Expect = 2.145e-80 Identity = 218/827 (26.36%), Postives = 371/827 (44.86%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNI 2777
LPH + ++E +P + + + + ++LY+RN+ SWL +PKVQLT ++ + + ++ D++L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK ++E+K++ + K+++K+++ + +S + D + L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S++ +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I + + N+
Sbjct: 43 LPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAP-----------------------------------------YNSDSVL------------VHRIHCYLERHGLINFGVYKRLKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVISKQVNMELAKIKQKCPLYEANGQGVPKEKDEMVEQEFNRLLEATSYLSHQLDFNILNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQDELKELLNKMV------NVKEKIKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKEYDQLAETQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFW-DSSVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGVMYNL 696
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Match: pcbd1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:Xenbase;Acc:XB-GENE-975699]) HSP 1 Score: 278.485 bits (711), Expect = 4.023e-80 Identity = 218/827 (26.36%), Postives = 371/827 (44.86%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNI 2777
LPH + ++E +P + + + + ++LY+RN+ SWL +PKVQLT ++ + + ++ D++L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK ++E+K++ + K+++K+++ + +S + D + L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S++ +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I + + N+
Sbjct: 83 LPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAP-----------------------------------------YNSDSVL------------VHRIHCYLERHGLINFGVYKRLKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVISKQVNMELAKIKQKCPLYEANGQGVPKEKDEMVEQEFNRLLEATSYLSHQLDFNILNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQDELKELLNKMV------NVKEKIKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKEYDQLAETQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFW-DSSVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGVMYNL 736
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Match: pcbd1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:Xenbase;Acc:XB-GENE-975699]) HSP 1 Score: 279.256 bits (713), Expect = 9.885e-80 Identity = 218/827 (26.36%), Postives = 371/827 (44.86%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNI 2777
LPH + ++E +P + + + + ++LY+RN+ SWL +PKVQLT ++ + + ++ D++L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK ++E+K++ + K+++K+++ + +S + D + L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S++ +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I + + N+
Sbjct: 168 LPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAP-----------------------------------------YNSDSVL------------VHRIHCYLERHGLINFGVYKRLKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVISKQVNMELAKIKQKCPLYEANGQGVPKEKDEMVEQEFNRLLEATSYLSHQLDFNILNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQDELKELLNKMV------NVKEKIKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKEYDQLAETQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFW-DSSVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGVMYNL 821
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Match: pcbd1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:Xenbase;Acc:XB-GENE-975699]) HSP 1 Score: 279.256 bits (713), Expect = 1.220e-79 Identity = 218/827 (26.36%), Postives = 371/827 (44.86%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNI 2777
LPH + ++E +P + + + + ++LY+RN+ SWL +PKVQLT ++ + + ++ D++L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK ++E+K++ + K+++K+++ + +S + D + L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S++ +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I + + N+
Sbjct: 175 LPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAP-----------------------------------------YNSDSVL------------VHRIHCYLERHGLINFGVYKRLKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVISKQVNMELAKIKQKCPLYEANGQGVPKEKDEMVEQEFNRLLEATSYLSHQLDFNILNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQDELKELLNKMV------NVKEKIKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKEYDQLAETQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFW-DSSVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGVMYNL 828
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Match: pcbd1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [Source:Xenbase;Acc:XB-GENE-975699]) HSP 1 Score: 263.462 bits (672), Expect = 1.657e-75 Identity = 214/826 (25.91%), Postives = 364/826 (44.07%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNI 2777
LPH + ++E +P + + + + ++LY+RN+ SWL +PKVQLT ++ + + ++ D++L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ + L ++ +V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK ++E+K++ + K+++K+++ + +S + D + L S++R C + + +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S++ +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I + + N+
Sbjct: 18 LPHDRMTSQEAACFPDIISGPQQTQKVFLYIRNRTLQSWLDNPKVQLTFENTLQQLEAP-----------------------------------------YNSDSVL------------VHRIHCYLERHGLINFGVYKRLKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGELIAFLKQRCKFQFTV---------------PKEKDEMVEQEFNRLLEATSYLSHQLDFNILNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQDELKELLNKMV------NVKEKIKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKEYDQLAETQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFW-DSSVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGVMYNL 655
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Match: Kdm1a (lysine (K)-specific demethylase 1A [Source:MGI Symbol;Acc:MGI:1196256]) HSP 1 Score: 273.092 bits (697), Expect = 1.586e-77 Identity = 214/822 (26.03%), Postives = 364/822 (44.28%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + I + +G +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 184 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKR----IKPLPIKKTG----KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 831
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Match: Kdm1a (lysine (K)-specific demethylase 1A [Source:MGI Symbol;Acc:MGI:1196256]) HSP 1 Score: 272.707 bits (696), Expect = 3.076e-77 Identity = 214/822 (26.03%), Postives = 364/822 (44.28%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + I + +G +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 204 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKR----IKPLPIKKTG----KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 851
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Match: Kdm1a (lysine (K)-specific demethylase 1A [Source:MGI Symbol;Acc:MGI:1196256]) HSP 1 Score: 174.866 bits (442), Expect = 5.009e-45 Identity = 113/350 (32.29%), Postives = 172/350 (49.14%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
W FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 362 WHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 661 HSP 2 Score: 87.0409 bits (214), Expect = 5.313e-17 Identity = 58/246 (23.58%), Postives = 109/246 (44.31%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTG 1046
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + I + +G +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G
Sbjct: 92 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKR----IKPLPIKKTG----KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANG 276
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Match: Kdm1a (lysine (K)-specific demethylase 1A [Source:MGI Symbol;Acc:MGI:1196256]) HSP 1 Score: 123.25 bits (308), Expect = 4.218e-30 Identity = 87/344 (25.29%), Postives = 158/344 (45.93%), Query Frame = 3
Query: 330 CAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP----VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEE 1346
++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + I + +G +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ + I+K L+E++N+M K + ++++ +A E
Sbjct: 2 TSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKR----IKPLPIKKTG----KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASE 284
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Match: Kdm1b (lysine (K)-specific demethylase 1B [Source:MGI Symbol;Acc:MGI:2145261]) HSP 1 Score: 101.293 bits (251), Expect = 2.856e-21 Identity = 84/344 (24.42%), Postives = 155/344 (45.06%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGH--SNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
+NLE G+ L+ +S R ++ +G + G+ ++ L + I + + V+ I+Y+ + + +T D + A V+ T+PL +L+ A QF+PPL + K+K+IN+LG G+ +K+ L F RFW F + QRG F FY + + ++ V+ G+A + + + D ++ ++ + LR++F +++I PEP+ +V RW+ +P+ + +S++ S + +A +E+ GTV FFAGE T+ T+ GA +SG++ AS I
Sbjct: 546 LSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDI-RLKSPVQSIDYTGDEVQVTTT-------DGMGHSAQKVLVTVPLAILQR--------GAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQ-----------------------QSVLMSVITGEAVASL---RTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIA-----EEIQ----------GTV-------FFAGEATNRHFPQTVTGAYLSGVREASKI 823
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Match: sp|Q6ZQ88|KDM1A_MOUSE (Lysine-specific histone demethylase 1A OS=Mus musculus OX=10090 GN=Kdm1a PE=1 SV=2) HSP 1 Score: 273.092 bits (697), Expect = 1.109e-76 Identity = 214/822 (26.03%), Postives = 364/822 (44.28%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + I + +G +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 184 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKR----IKPLPIKKTG----KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 831
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Match: sp|O60341|KDM1A_HUMAN (Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2) HSP 1 Score: 272.707 bits (696), Expect = 1.423e-76 Identity = 213/822 (25.91%), Postives = 362/822 (44.04%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAI----KIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + + ++L++RN+ WL +PK+QLT ++ + + ++ D +L VH +LERHG +N G + + T + +V +IG+G+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ + K+++K+++ + K + + P + + + R +DE K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK ++ +GFG +KVVLCF FW S + +F + + RGE F+ K ++ +V G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + + Q +P+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 183 LPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAP-----------------------------------------YNSDTVL------------VHRVHSYLERHGLINFGIYKRIKPLPTKKTG--------KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMV------NLKEKIKELHQQY-----------------------------KEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STSQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQ-----------PIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 830
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Match: sp|Q9VW97|LSDA_DROME (Possible lysine-specific histone demethylase 1 OS=Drosophila melanogaster OX=7227 GN=Su(var)3-3 PE=1 SV=1) HSP 1 Score: 169.474 bits (428), Expect = 1.109e-41 Identity = 120/352 (34.09%), Postives = 176/352 (50.00%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLG--TNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIP-LPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
W FANLE T LNNLSL+H D + + G ++ G+ + LT+ I + N+ VKEI+Y +G+ + A N S + +KAD+VV TL LGVLK ++ + +N +F PPLPDWK ++I LGFG +KVVLCF FW N +F + + RGE F++ S ++ +V G AA L + +TD + R ++ L++IF +VP+P V RW DP+ARG +SY+ G+S +D + +A P +P D +P+LFFAGEHT T+ GA +SGL+ A I +Y
Sbjct: 524 WHFANLEFANATRLNNLSLKHWD-QDDDFEFIGHHTTVRNGYSCVPVALTENLDI-RVNSAVKEIKYGTKGVEVVAENLKTSNSQ-MTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFW-DPNANLFGHVGSTTASRGEMFLFWSISSS------------------------PVLLALVAGMAA---NLVESVTDDIIIGRCMSVLKNIF--GNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAE-------------GLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYL 829 HSP 2 Score: 117.087 bits (292), Expect = 2.665e-25 Identity = 77/236 (32.63%), Postives = 123/236 (52.12%), Query Frame = 3
Query: 651 DNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTL--------HCKNLKKSSNALI--LKLMNRLQEVINEMEQHKIAVSNAYK 1325
D+ LV FLERHG++N G F K+ + I L +V VIGAG+SG+ A QLQ FG V+VLEA++ GGR+ TF++ + A++ +TG+ NP+ L KQ G+ + + + G PV KE IE E NRLL +A+ + + N VSLG+ LE ++S+Q + H + + + +I + + L++ I +++ +A+ N K
Sbjct: 229 DSEPSLVRRVHSFLERHGFINFGIF-KRLKPIPAKKLG-------KVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRK 456
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Match: sp|Q6YYZ1|LDL2_ORYSJ (Lysine-specific histone demethylase 1 homolog 2 OS=Oryza sativa subsp. japonica OX=39947 GN=Os08g0143400 PE=2 SV=1) HSP 1 Score: 137.117 bits (344), Expect = 1.164e-31 Identity = 103/344 (29.94%), Postives = 152/344 (44.19%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
W ANLE L+ LSL H D + G ++ G L+ L + Y VK IE+ +G+ IT E FKAD+ + T PLGVLK + + F P LP+ K+++I LGFG+ +KV + F FW + F L +R +RGEF FY++ A ++ +V G+AA + +K V + R L L+ I+ + + VP+P RW DP G +S+I G+S D + +A ++ N R LFFAGE T+ A T+ GA++SGL+ AS I
Sbjct: 316 WHLANLEFSNAGCLSELSLAHWD-QDDQYEMGGDHCFLAGGNARLVHALCDGVPVL-YEKTVKRIEHGEDGVSITV-------EGGQVFKADMALCTAPLGVLK--------SRSIIFEPELPERKLEAIQRLGFGLLNKVAMVFPHVFW-DEEIDTFGCLNKERSKRGEFFLFYSYHTVSG---------------------GAVLIALVAGEAALEF--EKVDPAVAL-HRVLGILKGIYGPKGVTVPDPIQSCCTRWGSDPLCSGSYSHIRVGSSGTDYDILA--------ESVNDR--------------LFFAGEATNRAYPATMHGALLSGLREASKI 595
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Match: sp|Q8VXV7|LDL1_ARATH (Lysine-specific histone demethylase 1 homolog 1 OS=Arabidopsis thaliana OX=3702 GN=LDL1 PE=1 SV=1) HSP 1 Score: 133.65 bits (335), Expect = 1.842e-30 Identity = 97/346 (28.03%), Postives = 152/346 (43.93%), Query Frame = 3
Query: 1713 WFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICK 2750
W ANLE T L NLS+ + D + G +I G + + L + IF Y + V+ I Y + G+++ N F D+ + T+PLGVLK+ + +F P LP K ++I LGFG+ +KV + F FWG + F +L RGEF FY++S +V +V G AA + + L+ + KR L LR I+ + I VP+P RW +D ++ G +SY+ G+S D + +A V ++FFAGE T+ T+ GA +SG++ A++I +
Sbjct: 424 WHLANLEYANATLLGNLSMAYWD-QDDPYEMGGDHCFIPGGNEIFVHALAENLPIF-YGSTVESIRYGSNGVLVYTGNKE--------FHCDMALCTVPLGVLKK--------GSIEFYPELPHKKKEAIQRLGFGLLNKVAMLFPCNFWGE-EIDTFGRLTEDPSTRGEFFLFYSYSSVSG---------------------GPLLVALVAGDAAERF---ETLSPTDSVKRVLQILRGIYHPKGIVVPDPVQALCSRWGQDKFSYGSYSYVAVGSSGDDYDILA---------------------ESVGDGRVFFAGEATNRQYPATMHGAFLSGMREAANILR 705 HSP 2 Score: 82.4185 bits (202), Expect = 1.286e-14 Identity = 63/185 (34.05%), Postives = 91/185 (49.19%), Query Frame = 3
Query: 666 LVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGL-PLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGW-----QAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKH---VSLGEMLEAL 1190
LV A FL HGY+N G I L G+ P V V+GAGL+G++AA QL G +VLVLE ++ PGGR++T + +G A++ +TGIN NP+ L +Q GL + + + G+ S+IE N+LL D K + +++ V LGE LE
Sbjct: 230 LVDTAYNFLLEHGYINFGL----APVIKEAKLRSFDGVEPPNVVVVGAGLAGLVAARQLLSMGFRVLVLEGRDRPGGRVKTRKMKGGDGVEAMADVGGSVLTGINGNPLGVLARQLGLPLHKVRDICPLYLPNGELADASVDSKIEASFNKLL----DRVCKLRQSMIEENKSVDVPLGEALETF 406
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Match: A0A3Q0KQ06 (Putative lysine-specific histone demethylase 1 OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 341.273 bits (874), Expect = 1.611e-96 Identity = 280/1029 (27.21%), Postives = 466/1029 (45.29%), Query Frame = 3
Query: 294 AASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSL-IHSINTSSCDKFFLDI---ISSRLCNHQ-KNEESSSVKTQN--------RTNGVDKTLKKFDIDAILKDNF-------YKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSL------CGSGGLPLQV------------------------------------------------TVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTL-----DKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKM----KKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGD------TSNEEE-----------DTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTV------------------------------------VKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESI--------------NNPLGTN------APQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKA-------ATNYTLDKDLTDVEMGKRALAALRDIFL-----------------------------KRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-----PVQELDTSNQRQRRSGGTVQVAV----PKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFP-QLP 2771
A+ IC LP EL AEE +++P+L + + + K Y+ VRN AC+ W +D Q+T L I+ +N S + + I +++ L HQ N +SSV +N + + ++L++ L N+ K NL ++ ++ + FLER+GY+N G F + +T+ S + G P+++ +IGAG+SG+IAA QL YFG KV +LE+++ GGR+ T ++ G+ AE+ +TG++ NPV L++Q L + +N+D + ++ G ++++ +IE E NRLL A +C L++L + +SLG+++E L+ Q H LK + LI +L++R ++++M + + AY+KW+ A + + + + SK A+++ + + N+++ SP ST+ G +SN + +TD + + N + Q +V LS +KK P ++ K + ++ P M L +++ ++DW ANLE T L+NLSLRH D + SG ++ G+ ++ L T Q TV VK I YSN G+ + +N+A S++D + ++AD ++ TLPLG+LKESI N TN P+F P LPDWKI +I LGFG+ +KVVL F+ FW S+ +F + RGE F++ + K + E++ G A +T++ L + L + + RA+ LR IF K+K+ +P P YV RW DPY+RG +SY+ GA+ AD + +A P+ E T+ +S G +++ P++FFAGEHT T+ GA++SGL+ A+ + +YFP Q P
Sbjct: 122 ASQICRLPAKELSAEETQLFPFLESSSNSLKESYIAVRNLACLMWSEDSCTQVTPNRLFIYVVNNMSVENLRVMIDSGLTTPLPVHQGSNSSASSVCEENSSCVGRVRHSKELSRSLQRHLTSLTLPSNYSPWGTPTAKANLERMTYLVVLFLERYGYINFGIFKIISPPLTHVSSSRTADPATTSGSPMEILDKSDVQLTPRRAAAEKALAATRRANNSHSSSTLPVSSSSTSLTTPHFIIIGAGISGLIAARQLTYFGAKVTILESRDRVGGRIWTCRKGGYHAELGAMVVTGLSANPVTILVRQLSLNLLPINTDCSLYDSQGHLINRDLDEQIEEEFNRLLGTAAYVCHSKGLDSLILDSGVEIPLSLGQVIELLIKYQEKHKIQLKITHRKLISQLLDRKNSLLDQMVIERKNIETAYEKWHSASKALNNQSSPNRHYTQQSKTQNPAQNKSR-VRNDSSPCSPRSSSTELDGKLVIESASSNGSQKSVNNNPVRLSSSTDISQRPSLPVFNVSAQFEVRQLLSHLHEAWKKFQPLQTALSQVNKQLDILLQEPPKDMYLTKEERSILDWHLANLEFANATELHNLSLRHWD-QDDLFELSGDHCVLQDGYGSVTDNLAHYITSGQSLTVGLKPRDNHLTSVTTTTSSSTLSTYKLGSGHIELKSTVKRISYSNTGVQVDVLNSAFSQDDLIEYEADALICTLPLGILKESIQQDNETTMHQSQITTNESSTNCLTKLVVPRFEPRLPDWKISAIQRLGFGVLNKVVLIFERSFWDRSH-NLFGHVNESTNSRGELFLFWSITDKPVLIALVAGRAACDLENEKTSPTRRLSPGSKGQNALINNCATSTSHLLGRGLKE-PIITRAMQVLRGIFTQEGSNSSSISNNNNNSNSSNCNGMHSNQEKKKVVIPNPIDAYVTRWRTDPYSRGSYSYVAVGATGADYDILAEPVYHPSSSSGEKQTTTHVSHQSHGIDGISMPTNNPRIFFAGEHTCRCYPATVHGALLSGLREAARVANYYFPGQTP 1146
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Match: G4VK09 (Putative lysine-specific histone demethylase 1 OS=Schistosoma mansoni OX=6183 GN=Smp_150560 PE=4 SV=1) HSP 1 Score: 333.569 bits (854), Expect = 1.407e-94 Identity = 259/948 (27.32%), Postives = 432/948 (45.57%), Query Frame = 3
Query: 294 AASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSL-IHSINTSSCDKFFLDI---ISSRLCNHQ-KNEESSSVKTQN--------RTNGVDKTLKKFDIDAILKDNF-------YKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGS------LCGSGGLPLQV------------------------------------------------TVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLD-----KKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKA-------ATNYTLDKDLTDVEMGKRALAALRDIFL-----------------------------KRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-----PVQELDTSNQRQRRSGGTVQVAV----PKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFP 2762
A+ IC LP EL AEE +++P+L + + + K Y+ VRN AC+ W +D Q+T L I+ +N S + + I +++ L HQ N +SSV +N + + ++L++ L N+ K NL ++ ++ + FLER+GY+N G F + +T+ S + G P+++ +IGAG+SG+IAA QL YFG KV +LE+++ GGR+ T ++ G+ AE+ +TG++ NPV L++Q L + +N+D + ++ G ++++ +IE E NRLL A +C L++L + +SLG+++E L+ Q H LK + LI +L++R +++++ INN +P+ +S+ +TD + + N + Q +V LS +KK P ++ K + ++ P M L +++ ++DW ANLE T L+NLSLRH D + SG ++ G+ ++ L Y T VK I YSN G+ + +N+A S++D + ++AD ++ TLPLG+LKE + P+F P LPDWKI +I LGFG+ +KVVL F+ FW S+ +F + RGE F++ + K + E++ G A +T++ L + L + + RA+ LR IF K+K+ +P P YV RW DPY+RG +SY+ GA+ AD + +A P+ E T+ +S G +++ P++FFAGEHT T+ GA++SGL+ A+ + +YFP
Sbjct: 151 ASQICRLPAKELSAEETQLFPFLESSSNSLKESYIAVRNLACLMWSEDSCTQVTPNRLFIYVVNNMSVENLRVMIDSGLTTPLPVHQGSNSSASSVCEENSSCVGRVRHSKELSRSLQRHLTSLTLPSNYSPWGTPTAKANLERMTYLVVLFLERYGYINFGIFKIISPPLTHVSSSRTADPATTSGSPMEILDKSDVQLTPRRAAAEKALAATRRANNSHSSSTLPVSSSSTSLTTPHFIIIGAGISGLIAARQLTYFGAKVTILESRDRVGGRIWTCRKGGYHAELGAMVVTGLSANPVTILVRQLSLNLLPINTDCSLYDSQGHLINRDLDEQIEEEFNRLLGTAAYVCHSKGLDSLILDSGVEIPLSLGQVIELLIKYQEKHKIQLKITHRKLISQLLDRKNSLLDQV-------------------------------------------INN-----NPVRLSS------------STDISQRPSLPVFNVSSQFEVRQLLSHLHEAWKKFQPLQTALSQVNKQLDILLQEPPKDMYLTKEERSILDWHLANLEFANATELHNLSLRHWD-QDDLFELSGDHCVLQDGYGSVTDNLA------HYITSVKRISYSNTGVQVDVLNSAFSQDDLIEYEADALICTLPLGILKEIV--------PRFEPRLPDWKISAIQRLGFGVLNKVVLIFERSFWDRSH-NLFGHVNESTNSRGELFLFWSITDKPVLIALVAGRAACDLENEKTSPTRRLSPGSKGQNALINNCATSTSHLLGRGLKE-PIITRAMQVLRGIFTQEGSNSSSISNNNNNSNSSNCNGMHSNQEKKKVVIPNPIDAYVTRWRTDPYSRGSYSYVAVGATGADYDILAEPVYHPSSSSGEKQTTTHVSHQSHGIDGISMPTNNPRIFFAGEHTCRCYPATVHGALLSGLREAARVANYYFP 1021
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Match: A0A5J4NTJ7 (Lysine-specific histone demethylase 1A OS=Paragonimus westermani OX=34504 GN=DEA37_0013948 PE=4 SV=1) HSP 1 Score: 319.316 bits (817), Expect = 7.225e-89 Identity = 266/1015 (26.21%), Postives = 429/1015 (42.27%), Query Frame = 3
Query: 294 AASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLC-------------------NHQKNEESSSVKTQNRTN-GVDKTLKKFDID---AILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQF---------------------NKQNESIT----------------------------NGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTL-----DKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEE------VKKMKKDSAGSKNDG-----------DAKDELKDI-------------NNEANSSSPIVVSTDFRGDTSNEEEDTTDR-VEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTI-------------------------------FQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESIN--------------NPLGTN------APQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDA--------------TVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIF--------------LKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVE---NVAIPLPVQELDTSNQRQRRSGG-TVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFP 2762
+A IC LP EL A+EL ++P+L ++ Y+ VRN ACM W +DP Q+T L +N + + +I + L ++E++ +T +N + + L + + K NL KL + A+ FLER+GY+N G F N + +T G++ G + V+GAG++G++AA QL YFG KV +LE+++ GGR+ T+++ E+ +TG++ NPV+ L KQ L + +N + + + G P+S+E +IE E NRLL A +C +++++ +++ +SLGE +E L+ Q H LK + LI+ ++ R E++N++ + + +AY++W A V S DG D+KD K+ N ++N P + + G +DT+ + P + N + Q +V LSE +KK P ++ + + ++ P + L + + + +DW ANLE T L+NLSLRH D + +G I++G+ L TL T + + VK I YS+ G+ + A+N A S++D + + D V+ TLPLGVLKESI N L T AP F P LPDWK+ +I LGFG+ +KVVL F++ FW S +F L + RE RGE F++ + S + T A T+ + RA+ LR IF +K +VP P V RW D +RG +SY+ GA+ D + + + D ++ R +G T + VP+LFFAGEHT T+ GA+++GL+ A+ + +FP
Sbjct: 110 SARICRLPAKELIADELSLFPFLETCPRPLRDAYICVRNFACMLWFEDPCFQVTPARLSVYVNHNLSAENVRLMIDAGLTAPLPVIGTPPPPQVLSVSSASSQSEDAGRARTNKDSNKALSRQLSALSLPPGWSPWAGPIAKANLEKLCYYAVLFLERYGYINFGLFKIVAPPLTRTSLSRTSSTSEVNPNDAPLTPRRAAAAAERALAASTRRSNSSSSLSTMTGTIAGPSP---HIIVLGAGIAGLMAARQLTYFGAKVTILESRDRVGGRIWTYRRGDTHGELGAMVVTGLSANPVSVLAKQVPLTLMPINVECSLYDPRGRPISRETDEKIEEEFNRLLGTAAFLCHTKSMDSITTDTGEERPLSLGEAVELLIRYQEQHKIQLKITHRKLIMSILERKNELLNQIAIERQNIEDAYERWQTATARANACLVVTPRVGVPFASSPDGNVTCTGAVQPRDSKDHPKESAILHDPRPMPKTNNTDSNELKPQL---EVEGQNDPPTQDTSPSCLPPPMLPVYNVSLQFEVRRLLSELHEAWKKFEPLQAALSRVNRQLDILLQSPPKDVYLTESERRTLDWHLANLEFANATELHNLSLRHWD-QDDMFELNGEHCVIREGYGTLTETLAAAITTSHIGPGPVHSTNTPNSKLRDISSSYSLGAGHIELKSSVKRITYSDRGVRVEALNAAFSQDDLITHEGDAVICTLPLGVLKESITASEQVNCKSISAKVNQLDTQSLTKLPAPIFQPSLPDWKVGAIRRLGFGVLNKVVLIFEKCFWDKSQ-NLFGHLSSSRETRGELFLFWSITPDRPVLIALVAGSAALDLERTPPPLTPRASPPQRSSPGSRLTTPTTANKSAGTHMNGPAHGLQEPIVARAMHILRGIFGSQDNATVNLNSGGPSQKKSVPNPIDAIVTRWYSDRDSRGSYSYVSIGATGLDYDLLGDSVLSASSISADHGSEALRATGSVTTKSPVPRLFFAGEHTCRCYPATVHGALLTGLREAARVANTFFP 1116
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Match: A0A4S2LI23 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007026 PE=4 SV=1) HSP 1 Score: 313.538 bits (802), Expect = 9.403e-87 Identity = 276/1004 (27.49%), Postives = 439/1004 (43.73%), Query Frame = 3
Query: 294 AASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCD---KFFLDI-ISSRLCN--HQKNEESSSVKTQNRTNGV-----DKTLKKFDIDAILKDNFY-------KDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSL----CG---------------------------------SGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTL-----DKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDA----------EEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVE---------------PKRTT--IINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQ----ALMSTLTKKST---------------------------IFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESI-------NNPLGT------------------NAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFY---------AFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLT---DVEMGKRALAALRDIF---------------LKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLP-------VQELDTSNQR---QRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFP 2762
AA IC L E EEL M+ +L T + Y+ VRN AC+ W +DP +Q+T L + ++ + + LD ++ L N HQ +SS + + G D T + + L ++ K NL K+ + AI FLER+GY+N G F +T+ SL C + L V VIGAG+SG++AA QL YFG KV +LE+++ GGR+ TF++ +E+ +TG++ NPV+ L+KQ L + +N D + + G V ++ ++E E N+LL A +C +++++ ++K +SLGE LE L+ Q H LK + LI+KL+ R E+++++ + + +AY +W A V + ++ N +D I E + + G T+ + + D +E P R + + N + Q +V LSE +KK P ++ + ++++ P + L ++ + ++W FANLE T LNNLSLRH D + +G ++ G+ AL S +T T + + VK I Y+ +G+ + +N A S++D + +AD VV TLPLGVLKES+ P T AP F PPLPDWK +I LGFG+ +KVVL F++ FW S +F + +E RGE F+ A ++ D S+ + VVG V G +T + + + RA+ LR IF + RK VP P V RW DP +RG +SY+ G++ D + + P+ QE D S++R ++ P++FFAGEHT T+ GA++SGL+ A+ + +FP
Sbjct: 126 AARICRLSPKEAVGEELGMFVFLVTATRPLREAYVCVRNFACLLWSEDPTIQVTVARLSDFVASNLSEENTRLMLDAGLTVPLPNGTHQPPGSTSSASSVSDDAGRIRTHKDGTSRTISRPSALPSSWLPWSTPAAKANLEKMCYYAILFLERYGYINFGMFKILAPPLTHVSLSRQTCSVDLTTESTATLRRTPSERSLVSTRRSGSTSSLSNSTQSLHVIVIGAGISGLMAARQLTYFGVKVTILESRDRVGGRIWTFRRGDSYSELGAMVVTGLSANPVSILVKQIPLTLVPINVDCSLYDPRGMLVPRDVDEKVEKEFNKLLGTAAFLCHTKSMDSITTETGEEKLLSLGEALEMLIRYQEKHKLQLKITHRKLIVKLLERKNELLDQIAVERQNIEDAYVRWQTATARANSCLIVTPRVNTVPLGNSADTNASSQRDADDGILKETSILRTARPPSRGGGGTAEDIKPDVDMLEVENQKCGPAQEDVNPPPRASLPVYNVSAQFEVRRLLSELHEAWKKFEPLQAALTRVNRQLEILLQSPPKEIYLTDEERRTLNWHFANLEFANATLLNNLSLRHWD-QDDAFELNGEHCVVRDGYSSMTDALASAITSSQTGPGPVPSNVTPNSKQREAPSPYTLGSGHIELKSSVKRIIYTEKGVRVDTLNAAFSQDDLIENEADAVVCTLPLGVLKESVQLATEHRTGPKTTGGGSHHHHPHQQLDLTKLKAPLFEPPLPDWKADAIQRLGFGVLNKVVLVFEKCFWDRSQ-NLFGHVNPTKESRGELFLFWSITDRPVLIALVAGQAALDLENSRPSPQRVSPGSRLSTSQVVGGVAGSKSTTGSSPVSVMHGLQEPIVARAMHILRGIFGSQDSSYNVSLGSSQMDRKRVVPNPIDAIVTRWYSDPDSRGSYSYVGVGSTGLDYDLLGNPVSGNILSGGPQESDKSSERVSPSKKPPTVSPSPTPRVFFAGEHTCRFYPATVHGALLSGLREAARVANTFFP 1127
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Match: A0A074ZYW8 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_01693 PE=4 SV=1) HSP 1 Score: 310.842 bits (795), Expect = 9.107e-86 Identity = 275/1004 (27.39%), Postives = 440/1004 (43.82%), Query Frame = 3
Query: 294 AASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCD---KFFLDI-ISSRLCN--HQK------NEESSSVKTQNRTN--GVDKTLKK----FDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSL----CGSGGL---------------------------------PLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTL-----DKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAE----------EEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVE---------------PKRTT--IINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQ----ALMSTLTKK--------STI-------------------FQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESI-------NNPLGTN------------------APQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFY---------AFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLT---DVEMGKRALAALRDIF---------------LKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLP-------VQELDTSNQR---QRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFP 2762
AA IC L E EEL M+ +L T + Y+ VRN AC+ W +DP +Q+T L + ++ + + LD ++ L N HQ S + RTN G +T + + K NL K+ + AI FLER+GY+N G F +T+ +L C + L V VIGAG+SG++AA QL YFG KV +LE+++ GGR+ TF++ +E+ +TG++ NPV+ L+KQ L + +N D + + G V ++ ++E E N+LL A +C +++++ ++K +SLGE LE L+ Q H LK + LI+KL+ R E+++++ + + +AY +W A V + ++ N +D + E + + G T+ + + D +E P R + + N + Q +V LSE +KK P ++ + ++++ P + L ++ + ++W FANLE T LNNLSLRH D + +G ++ G+ AL S +T STI + + VK I Y+ +G+ + +N A S++D + +AD VV TLPLGVLKES+ P T+ AP F PPLPDWK +I LGFG+ +KVVL F++ FW S +F + + +E RGE F+ A ++ D S+ + VVG V G +T + + + RA+ LR IF + RK VP P V RW DP +RG +SY+ G++ D + + P+ QE + S++R ++ P++FFAGEHT T+ GA++SGL+ A+ + +FP
Sbjct: 127 AARICRLSPKEAVGEELGMFVFLVTATRPLREAYVCVRNFACLLWSEDPTIQVTVGRLSDFVASNLSEENTRLMLDAGLTVPLPNGPHQPPGSTSSASSVSDDAGRIRTNKDGTSRTTSRPSALPSSWSPWGSPSAKANLEKMCYYAILFLERYGYINFGMFKILAPPLTHVNLSRQTCSVDLITESTATLRRTPSERSLVSTRRSGSTSSLSNPTQSLHVIVIGAGISGLMAARQLTYFGVKVTILESRDRVGGRIWTFRRGDSYSELGAMVVTGLSANPVSILVKQIPLTLVPINVDCSLYDPRGMLVPRDVDEKVEKEFNKLLGTAAFLCHTKSMDSITTETGEEKLLSLGEALEMLIRYQEKHKLQLKITHRKLIVKLLERKNELLDQIAVERQNIEDAYVRWQTATARANSCLIVTPRVNTVPLGNSADANTSSQRDADDGVLKETSILRTARPPSRGGGGTAEDIKPDVDMLEVENQKCGPAQEDINPPPRASLPVYNVSAQFEVRRLLSELHEAWKKFEPLQAALTRVNRQLEILLQSPPKEIYLTDEERRTLNWHFANLEFANATLLNNLSLRHWD-QDDAFELNGEHCVVRDGYSSMTDALASAITSSQTGPGPVPSTITPNSKQREAPCPYTLGPGHIELKSSVKRIIYTEKGVRVDTLNAAFSQDDLIENEADAVVCTLPLGVLKESVQLTTEHRTGPKTTSIRGDSGGHHQQLDLTKLRAPLFDPPLPDWKADAIQRLGFGVLNKVVLVFEKCFWDRSQ-NLFGHVNSTKESRGELFLFWSITDRPVLIALVAGQAALDLENSRPSPQRVSPGSRLSTSQVVGGVAGSKSTTGSSPVSVIHGLQEPIVARAMHILRGIFGSQDSSYTASLGSSQVDRKRVVPNPIDAIVTRWYSDPDSRGSYSYVGVGSTGLDYDLLGNPVSGNILSGGPQEAEKSSERVSPSKKPPTVSPSPTPRVFFAGEHTCRFYPATVHGALLSGLREAARVANTFFP 1128
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Match: kdm1a (lysine demethylase 1A [Source:NCBI gene;Acc:103023119]) HSP 1 Score: 281.567 bits (719), Expect = 7.358e-81 Identity = 220/821 (26.80%), Postives = 367/821 (44.70%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N + + ++LY+RN+ WL +PKVQLT +S + + ++ DA+L VH +LERHG +N G + + + + +V VIG G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ +K +++K+++ + +S + D + L S++R C + ++ K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y++ G + A+NT S +K D V+ TLPLGV+K+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 165 LPHDRMTSQEAACFPDIINGPQQTQKVFLYIRNRTLQLWLDNPKVQLTFESTVQQLEAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGLINFGIYKRVKPLPSKKTG--------KVIVIGGGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSFLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMVATK------EKVKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKDYDALAEQQAKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTSSGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVMKQQ------PPAVQFVPPLPEWKTSAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 812
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Match: kdm1a (lysine demethylase 1A [Source:NCBI gene;Acc:103023119]) HSP 1 Score: 275.018 bits (702), Expect = 1.556e-78 Identity = 220/827 (26.60%), Postives = 367/827 (44.38%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP------VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N + + ++LY+RN+ WL +PKVQLT +S + + ++ DA+L VH +LERHG +N G + + + + +V VIG G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ +K +++K+++ + +S + D + L S++R C + ++ K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y++ G + A+NT S +K D V+ TLPLGV+K+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 156 LPHDRMTSQEAACFPDIINGPQQTQKVFLYIRNRTLQLWLDNPKVQLTFESTVQQLEAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGLINFGIYKRVKPLPSKKTG--------KVIVIGGGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSFLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMVATK------EKVKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKDYDALAEQQAKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTSSGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVMKQQ------PPAVQFVPPLPEWKTSAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 809
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Match: kdm1a (lysine demethylase 1A [Source:NCBI gene;Acc:103023119]) HSP 1 Score: 275.404 bits (703), Expect = 1.910e-78 Identity = 220/827 (26.60%), Postives = 367/827 (44.38%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP------VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPF---FDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N + + ++LY+RN+ WL +PKVQLT +S + + ++ DA+L VH +LERHG +N G + + + + +V VIG G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H +KK +EE+K++ +K +++K+++ + +S + D + L S++R C + ++ K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y++ G + A+NT S +K D V+ TLPLGV+K+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 174 LPHDRMTSQEAACFPDIINGPQQTQKVFLYIRNRTLQLWLDNPKVQLTFESTVQQLEAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGLINFGIYKRVKPLPSKKTG--------KVIVIGGGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSFLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH-------WKKIVKTQEELKELLNKMVATK------EKVKELHQQYKEASEVKPPRDITAEF----------------------------LVKSKHRDLTALCKDYDALAEQQAKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTSSGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVMKQQ------PPAVQFVPPLPEWKTSAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 827
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Match: zgc:66484 (spermine oxidase-like [Source:NCBI gene;Acc:103026971]) HSP 1 Score: 97.4413 bits (241), Expect = 1.194e-20 Identity = 89/319 (27.90%), Postives = 136/319 (42.63%), Query Frame = 3
Query: 1833 GFQALMSTLTKK--STIFQYNTVVKEIEY-------SNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGAS-LADVENVAIPLPVQ-ELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
G+QA++ L K S I N VK I + +NE + + E+D VF +AD V+ T+ LGVLK+ F P LP K+ +I LGFG DK+ LCF ERFW I E + ++ E + G + + + G + G+ A + + L D E+G + LR +VP+ S + + RW DP G ++++P + + + E +A P+P Q ++ S Q + FAGE TH T GA MSG++ A + HY
Sbjct: 210 GYQAILDILLKDLPSEIILTNKAVKSIHWDLKEQLQANEKGGLNHPVKLICEDDGVF-EADHVIVTVSLGVLKQQAGT-------LFKPSLPKSKLTAIEQLGFGTVDKIFLCFNERFWPEDCAGIQLVWDEGPEDKS------VYTSHSEGEAWKETWYKKICGFDSVARHPTVLCGWITGREALHM---ETLQDSEVGDACVRLLRSF---TGWSVPDVSKVLISRWGLDPQVLGSYTFVPHNVNGVKEHEALAAPIPFQNKIPESKPLQ-------------VLFAGEATHVNFYTTTHGAYMSGVREAQRLITHY 495
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Match: ENSAMXT00000006332.2 (spermine oxidase-like [Source:NCBI gene;Acc:103027446]) HSP 1 Score: 97.0561 bits (240), Expect = 1.549e-20 Identity = 88/311 (28.30%), Postives = 131/311 (42.12%), Query Frame = 3
Query: 1833 GFQALMSTLTKK--STIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGAS-LADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
G+QAL+ L K S I N VK I++ + + L ED F+AD V+ T+ LGVLK+ A F P LP K+ +I LGFG +K+ LCF ERFW I E + ++ E + G + + + G + G+ A + + L D E+ L LR +VP+ S + + RW D G +S +P+G + + + PLP+ QR+ +QV FAGE TH T GA +SG++ A + HY
Sbjct: 205 GYQALLDYLMKDLPSGIILNNKAVKSIQWDLKPQGGSNHPVKLICEDDEIFEADHVIVTVSLGVLKQKA-------ATMFEPSLPQSKLTAIEQLGFGTVNKIFLCFNERFWPEDCEGIQLVWNEGPEDKS------VYTSHSEGEAWKETWYKKICGFDSVARHPTVLCGWIAGREALHM---ETLQDSEVKDTCLRLLRSF---TGWSVPDVSKVLISRWGHDSRVLGSYSSVPKGVNGFEKQKELGEPLPL-------QRKASDSKPLQV-----LFAGEATHENFYATTHGAYLSGIREAQRLINHY 484
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Match: kdm1a (lysine (K)-specific demethylase 1a [Source:ZFIN;Acc:ZDB-GENE-030131-7828]) HSP 1 Score: 275.404 bits (703), Expect = 4.475e-80 Identity = 224/823 (27.22%), Postives = 365/823 (44.35%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNE-GIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + N + +LY+RN+ WL PK QLT + ++ + + ++ DA +LVH +LERHG +N G F + LP++ V VIGAG+SG+ AA QLQ FG V +LEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + T G V KE +E E NRLL A + + N L+ K VSLG+ LE ++ LQ H K+ + I+K L++ +N+M + + K+ + ++E ++K +D+ E +V + R +N A EY + IK+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + SGS + ++ G+ + L + I + NT V++++Y+ G + +T S + + +K D V+ TLPLGVLK+ A QF PPLP+WK +I +GFG +KVVLCF FW N+ +F + + RGE F+ K ++ +V G+AA + ++++D + RA+A L+ IF VP+P V RW DP+ARG +SY+ G++ D + +A P+ P L S Q + +LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 74 LPHDRMTSQEAACFPDIVNGNPQTQKAFLYIRNRTLQLWLDQPKTQLTFEQMLQQLESP-----------------------------------------YNSDA------------QLVHRVFNYLERHGLINFGIFKRVKP------------LPVKKVGKVMVIGAGVSGLAAARQLQSFGMDVTILEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYETNGQSVPKEKDEMVEREFNRLLEATSYLSHHLDFNFLNGKPVSLGQALELVIQLQEKHVKDEQIEHWKKIVKSQEELKDFLNKM----VTLKERIKELHQQQKEASEVKPP--------------RDVTAE------FLVKSKLR----------------------------DLNAACREYDE-------LAESQIKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFSGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVKYTPAVGCEVLTQHTRSSSQS-LIYKCDAVLCTLPLGVLKQQ------PPAVQFFPPLPEWKTTAIQRMGFGNLNKVVLCFDRVFW-DLNVNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALVAGEAA---GIMENVSDDVIVARAMAVLKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSNGNDYDLMAQPIAPPPSLPGSPQ-----------PIHRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 722
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Match: KDM1B (lysine demethylase 1B [Source:HGNC Symbol;Acc:HGNC:21577]) HSP 1 Score: 117.472 bits (293), Expect = 3.507e-27 Identity = 96/344 (27.91%), Postives = 161/344 (46.80%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHS--NMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
ANLE G +L +S R ++ +G + G+ ++ L + + + +T VK ++YS E + ++TA + + AD V+ T+PL +++ + +F PPLP+ KIK++ +LG G+ +K+ L F RFW H F L ++RG F FY K S+ + ++ VV G + L +DL+D ++ +++ ALR IF ++ NVP+P +V RW DP+A +SY+ G + + +A Q+L+ KLFFAGE T+ T+ GA +SG++ AS I
Sbjct: 441 LANLEYACGANLRQVSARSWDHNEFFAQFAGDHTLLTAGYSTILHRLAEGLDV-RLHTPVKRVDYSGECV---KVHTATG----MTYIADKVLVTIPLALMQLGVL--------EFCPPLPERKIKALQSLGAGLIEKIGLQFPFRFWEHKIRGADYFGHLPPSHDRRGLFGVFYDMDPKSSTGE------------------QCVLMSVVSGDSV---ALIRDLSDSQVVSQSMQALRAIFPEQ--NVPDPLRWFVTRWGSDPWALMAYSYVRPGGTGEAYDVLA-----QDLNG-----------------KLFFAGEATNRHFPQTVTGAYLSGVREASKI 723 HSP 2 Score: 56.225 bits (134), Expect = 3.207e-8 Identity = 66/260 (25.38%), Postives = 112/260 (43.08%), Query Frame = 3
Query: 432 KDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ-----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITG--INNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEAL 1190
+DP + L ++LI ++ +C +F V K ++ + +++ ++ L ++H A+ R G +N G + G LPL V VIGAG +G+ AA QL FG KV+VLEA+E GGR+ + G I +NNP++ + +Q G+ + V+ ++++ +G R++ N LL DI +++ T VSLGE +E L
Sbjct: 203 RDPTMYLALRNLILALWNMNCKEFLT---------------------------VQKCMQHLLVRGLIRVRCMQE-LEGILHFAM----RKGLINTGLLSAHP---------GRPLLPLHYRKNSVVVIGAGPAGLAAARQLHNFGLKVIVLEARERIGGRVWDDRSLGGTTVGRGAQIVNGCVNNPISLMCEQLGIRMHVLGEACELLDESGRVTDPALDKRMDFHFNALL----DIIAQWRTTTEPAHDVSLGEKMEEL 417
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Match: KDM1B (lysine demethylase 1B [Source:HGNC Symbol;Acc:HGNC:21577]) HSP 1 Score: 117.472 bits (293), Expect = 4.707e-27 Identity = 95/344 (27.62%), Postives = 158/344 (45.93%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHS--NMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
ANLE G +L +S R ++ +G + G+ ++ L + + + +T VK ++YS E + ++TA + + AD V+ T+PL +++ + +F PPLP+ KIK++ +LG G+ +K+ L F RFW H F L ++RG F FY K ++ VV G + L +DL+D ++ +++ ALR IF ++ NVP+P +V RW DP+A +SY+ G + + +A Q+L+ KLFFAGE T+ T+ GA +SG++ AS I
Sbjct: 539 LANLEYACGANLRQVSARSWDHNEFFAQFAGDHTLLTAGYSTILHRLAEGLDV-RLHTPVKRVDYSGECV---KVHTATG----MTYIADKVLVTIPLALMQLGVL--------EFCPPLPERKIKALQSLGAGLIEKIGLQFPFRFWEHKIRGADYFGHLPPSHDRRGLFGVFYDMDPKGE---------------------QCVLMSVVSGDSV---ALIRDLSDSQVVSQSMQALRAIFPEQ--NVPDPLRWFVTRWGSDPWALMAYSYVRPGGTGEAYDVLA-----QDLNG-----------------KLFFAGEATNRHFPQTVTGAYLSGVREASKI 818 HSP 2 Score: 51.6026 bits (122), Expect = 8.592e-7 Identity = 59/208 (28.37%), Postives = 97/208 (46.63%), Query Frame = 3
Query: 591 VDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ-----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITG--INNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLG-EMLEAL 1190
V K ++ + +++ ++ L ++H A+ R G +N G + G LPL V VIGAG +G+ AA QL FG KV+VLEA+E GGR+ + G I +NNP++ + +Q G+ + V+ ++++ +G R++ N LL DI +++ T VSLG E +E L
Sbjct: 326 VQKCMQHLLVRGLIRVRCMQE-LEGILHFAM----RKGLINTGLLSAHP---------GRPLLPLHYRKNSVVVIGAGPAGLAAARQLHNFGLKVIVLEARERIGGRVWDDRSLGGTTVGRGAQIVNGCVNNPISLMCEQLGIRMHVLGEACELLDESGRVTDPALDKRMDFHFNALL----DIIAQWRTTTEPAHDVSLGAEKMEEL 515
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Match: KDM1B (lysine demethylase 1B [Source:HGNC Symbol;Acc:HGNC:21577]) HSP 1 Score: 117.087 bits (292), Expect = 5.680e-27 Identity = 95/344 (27.62%), Postives = 158/344 (45.93%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHS--NMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
ANLE G +L +S R ++ +G + G+ ++ L + + + +T VK ++YS E + ++TA + + AD V+ T+PL +++ + +F PPLP+ KIK++ +LG G+ +K+ L F RFW H F L ++RG F FY K ++ VV G + L +DL+D ++ +++ ALR IF ++ NVP+P +V RW DP+A +SY+ G + + +A Q+L+ KLFFAGE T+ T+ GA +SG++ AS I
Sbjct: 547 LANLEYACGANLRQVSARSWDHNEFFAQFAGDHTLLTAGYSTILHRLAEGLDV-RLHTPVKRVDYSGECV---KVHTATG----MTYIADKVLVTIPLALMQLGVL--------EFCPPLPERKIKALQSLGAGLIEKIGLQFPFRFWEHKIRGADYFGHLPPSHDRRGLFGVFYDMDPKGE---------------------QCVLMSVVSGDSV---ALIRDLSDSQVVSQSMQALRAIFPEQ--NVPDPLRWFVTRWGSDPWALMAYSYVRPGGTGEAYDVLA-----QDLNG-----------------KLFFAGEATNRHFPQTVTGAYLSGVREASKI 826 HSP 2 Score: 51.9878 bits (123), Expect = 7.782e-7 Identity = 59/208 (28.37%), Postives = 97/208 (46.63%), Query Frame = 3
Query: 591 VDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ-----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITG--INNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLG-EMLEAL 1190
V K ++ + +++ ++ L ++H A+ R G +N G + G LPL V VIGAG +G+ AA QL FG KV+VLEA+E GGR+ + G I +NNP++ + +Q G+ + V+ ++++ +G R++ N LL DI +++ T VSLG E +E L
Sbjct: 334 VQKCMQHLLVRGLIRVRCMQE-LEGILHFAM----RKGLINTGLLSAHP---------GRPLLPLHYRKNSVVVIGAGPAGLAAARQLHNFGLKVIVLEARERIGGRVWDDRSLGGTTVGRGAQIVNGCVNNPISLMCEQLGIRMHVLGEACELLDESGRVTDPALDKRMDFHFNALL----DIIAQWRTTTEPAHDVSLGAEKMEEL 523
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Match: smox (spermine oxidase [Source:ZFIN;Acc:ZDB-GENE-031201-3]) HSP 1 Score: 92.4337 bits (228), Expect = 1.322e-19 Identity = 75/268 (27.99%), Postives = 113/268 (42.16%), Query Frame = 3
Query: 1962 EDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWG---HSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
ED F AD V+ T LGVLKE + F PPLP K+ +I LG G DK+ L F+E FWG +S ++ + ++ + +Y + + + G VCG A L+ + D E L F+ N+ +P I W DPY RG +SY G++ AD++ +A PLP + + ++ +L FAGE TH T GA+++G + A I + Y
Sbjct: 311 EDGECFLADHVILTASLGVLKER-------HGTLFDPPLPGDKVAAIEKLGIGTTDKIFLEFEEPFWGPECNSIQLVWEDDVGEESEQDQLRPWY-------------RKVCSFDVLYPASRYGHVLGGWVCGDEA----LEMEKLDDETVAETCTELLRKFMGNP-NIVKPRKILRTFWGSDPYTRGSYSYTRVGSNGADIDTLAEPLPYTD-------------STKIQPLQLLFAGEATHRKFYSTTHGALLTGQREAGRIVEMY 540
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Match: EDO41050 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5A0]) HSP 1 Score: 139.428 bits (350), Expect = 8.233e-34 Identity = 94/262 (35.88%), Postives = 131/262 (50.00%), Query Frame = 3
Query: 1977 FKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQ-VAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
FKAD V+ TLPLGVLK NP A QF PPLP+WK+ +++ +GFG +KVVLCF FW N +F + RGE F+ K ++ +V G+AA N +++ D + RA+ LR IF NVP P V RW D ++RG +SY+ G+S D + +A PV L T+N + GT Q + P++FFAGEHT T+ GA++SGL+ A I +
Sbjct: 505 FKADAVLITLPLGVLKA---NP---AAVQFHPPLPEWKMAAVHRMGFGNLNKVVLCFDRIFWD-PNTNLFGHVNGTTHTRGELFLFWNLYKA------------------------PVLISLVAGEAADNL---ENVPDDIIVSRAVGVLRGIF--GASNVPNPKESVVTRWKSDEWSRGSYSYVAAGSSGNDYDLMAS--PVAPLPTANV----APGTPQPLNPPRVFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 724 HSP 2 Score: 105.531 bits (262), Expect = 2.983e-23 Identity = 66/229 (28.82%), Postives = 117/229 (51.09%), Query Frame = 3
Query: 663 KLVHMAIGFLERHGYVNIGQFN--KQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGI-NNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDA 1340
KLV FLER+G +N G + K ++ +V ++G+G++G++AA QLQ FG V ++EA+E GGR+ TF++ + A++ +TG+ NP+ L Q + V + + + G PV K+ +E E NRLL A + + + N ++ K VSLG LE ++ +Q K + IL L + ++E + +M + ++++ +A
Sbjct: 130 KLVQRVHAFLERYGSINFGVYKMAKMPPTLKKSP---------KVIIVGSGIAGLMAARQLQSFGIDVTMVEARERVGGRVATFRKGQYIADLGAMVLTGLGGNPLTVLNNQISMEVHKIRQKCPLYESLGKPVPKDKDEMVEREFNRLLEATSFLSHQLDFNYMNGKPVSLGHALELVIKMQEKQVKEQQVEHAKKILSLQDHMKENLAKMVSIQEKARQTHREYTEA 349
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Match: EDO48257 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJG1]) HSP 1 Score: 78.1814 bits (191), Expect = 3.439e-16 Identity = 68/283 (24.03%), Postives = 113/283 (39.93%), Query Frame = 3
Query: 1896 VKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
V+ I YSN G+ + N + + A+ + T GVL + N F P LP WK +++ + + K+ L F+ +FW + A ++RG+F F + + ++ + G A ++ +D + +A LR ++ +PEP+ ++ RW+KDPY RG +S A D +N+ +P LDT LFFAGE T G +QGA ++G AA +
Sbjct: 8 VESISYSNAGVTVNLTNGNV-------YTAEHAICTFSSGVLNNGLVN--------FIPRLPKWKQDALSKVPMSFYTKIFLKFQIKFWEDKEFILHAS-----KRRGDFPVF--------------------QNVPINTKEGGVLMATITGSEALRI---ENQSDEDTRSEVMATLRQLYGV----IPEPTEMFYARWSKDPYTRGAYSDPTLDARPCDFDNMLLP-----LDT------------------LFFAGEATSEEWTGYMQGAYLTGKHAAKRV 220
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Match: EDO45265 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTH5]) HSP 1 Score: 80.4925 bits (197), Expect = 1.172e-15 Identity = 68/263 (25.86%), Postives = 112/263 (42.59%), Query Frame = 3
Query: 1974 FFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHS--NMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVP-KLFFAGEHTHSASIGTIQGAMMSGLKAASDICKH 2753
F A+ V+ TLPLGVLK + F+PPLP K +IN LG+G +++ L F++ FW + M + + Y F + + +V + G+AA + ++D E+ L+ ++I P + +W + +RG ++YIP + AD++ +A PLP E G Q VP K+ FAGE T+ ++ T GA +SG++ A I +
Sbjct: 252 IFTAEHVIVTLPLGVLKSR-------HEVIFNPPLPQIKKDAINRLGYGTINRIYLVFEKAFWSNEIKGMGLLWTNLDSNNWPSWVKELYIF--------------------YPTHKGSNVLVTWLSGEAAIQI---ESISDQEIAHECTRVLKAFTGLKEI--PGIKEVMKTKWHSNKLSRGSYTYIPRYSGGADIDILASPLPHLE------------GEAQGNVPCKILFAGEATNRSAYATTHGAYISGVREAKRILDY 470
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Match: EDO45214 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTH2]) HSP 1 Score: 75.0998 bits (183), Expect = 4.948e-14 Identity = 69/295 (23.39%), Postives = 112/295 (37.97%), Query Frame = 3
Query: 1887 NTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKD-------LTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICK 2750
N VV+EI YSN G+ +T D + + T GVL T+ FSPPLP+WK++SI + + K+ L F FW + ++A + RG + + +D G+ G + T+ D +D E + LR ++ ++PEP + RW+++ + RG F + G + D N +Q V L+FAG+ T G +Q A +SG + A++I K
Sbjct: 212 NAVVREIRYSNYGVTVTTT-------DGRTYSGRYSLCTFSTGVL--------ATDMVNFSPPLPEWKMESIYKVPMRYYTKIFLQFPTDFWDDNEFILYAH-----KNRGHYPIW----------------------------MDIDRPGLAPGSKILHVTVTGDEALRVEGQSDEETKAEIMRELRKVYGS---DIPEPIDFFYSRWSRNNFTRGSFPNVMIGTTKEDFHN-----------------------LQGNVKSLYFAGDATEYEWWGFVQSAYLSGRRKATEILK 432
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Match: EDO42068 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2M9]) HSP 1 Score: 59.3066 bits (142), Expect = 1.840e-9 Identity = 59/272 (21.69%), Postives = 112/272 (41.18%), Query Frame = 3
Query: 1764 SLRHGGCHDSNVDTSGSEIYI--KKGFQALMS-TLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVA 2570
S+R +N+D ++ Y ++GF + + T+ + N V ++Y+N G+ +T + + + AD VV T GVL ++ +F PPLP WK ++ + ++ K+ L F +FW + + A +K RG + F + V+++++ V + + E + + L+ I+ NV EP+ I+ RW+++PY RG +S + G E +A
Sbjct: 19 SVRLEQVSFNNMDARETDFYSTDQRGFYNIFNETVETFKDKIKLNETVARVKYNNTGVEVTTSSGDV-------YSADYVVCTFSTGVL--------ASDMVEFVPPLPKWKQEAYLSHPMSIYTKIFLKFDHKFWDDNEYILHASMK-----RGYYPVF------------------QDLARPGIFPVNSSILLVTVTDTESRRIERQPF--AETKREIVEMLKKIYGN---NVTEPTDIFYDRWSQNPYIRGAYSEVVVGTGSKSFEELA 247
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Match: kdm1a (lysine demethylase 1A [Source:NCBI gene;Acc:101172293]) HSP 1 Score: 280.026 bits (715), Expect = 2.699e-80 Identity = 227/825 (27.52%), Postives = 368/825 (44.61%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEA---IKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + ++LY+RN+ WL +PK+QLT ++ + ++ ++ DA+L VH +LERHG +N G + + LP + V VIG G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H W KK+ K ++EL+D+ N+ +VST R +++ V+P R L S++R C + + A +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 156 LPHDRMTSQEAACFPDIIGGPQQTQKVFLYIRNRTLQLWLDNPKIQLTFEATVQQLDAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGLINFGIYKRVKP------------LPAKKTGKVIVIGGGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLFEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH----------W-------KKIVK----------TQEELRDLLNK-------MVSTKERVKELHQQYKEACEVKPPRDITAE-------FLVKSKHRDLTALCKEYDELAEMQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 803
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Match: kdm1a (lysine demethylase 1A [Source:NCBI gene;Acc:101172293]) HSP 1 Score: 273.092 bits (697), Expect = 1.196e-77 Identity = 227/831 (27.32%), Postives = 368/831 (44.28%), Query Frame = 3
Query: 312 LPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQ----VTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGIN-NPVNQLIKQAGLGVSVMNSDVDIVNTTGDP------VSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEA---IKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPL-PVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYF 2759
LPH + ++E +P + + + ++LY+RN+ WL +PK+QLT ++ + ++ ++ DA+L VH +LERHG +N G + + LP + V VIG G+SG+ AA QLQ FG V VLEA++ GGR+ TF++ + A++ +TG+ NP+ + KQ + ++ + + G V KE +E E NRLL A + + + N L+ K VSLG+ LE ++ LQ H K+ E +H W KK+ K ++EL+D+ N+ +VST R +++ V+P R L S++R C + + A +K+ + ++ ++ P+ + L +D Q++DW FANLE T L+ LSL+H D + + +GS + ++ G+ + L + I + NT V+++ Y+ G + A+NT S +K D V+ TLPLGVLK+ A QF PPLP+WK +I +GFG +KVVLCF FW S + +F + + RGE F+ K ++ ++ G+AA + ++++D + R LA L+ IF VP+P V RW DP+ARG +SY+ G+S D + +A P+ P + ++Q VP+LFFAGEHT T+ GA++SGL+ A I +
Sbjct: 180 LPHDRMTSQEAACFPDIIGGPQQTQKVFLYIRNRTLQLWLDNPKIQLTFEATVQQLDAP-----------------------------------------YNSDAVL------------VHRIHSYLERHGLINFGIYKRVKP------------LPAKKTGKVIVIGGGVSGLAAARQLQSFGMDVTVLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLFEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKD---------------------EQIEH----------W-------KKIVK----------TQEELRDLLNK-------MVSTKERVKELHQQYKEACEVKPPRDITAE-------FLVKSKHRDLTALCKEYDELAEMQVKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWD-QDDDFEFTGSHLTVRNGYSCVPVALAEGLDI-KLNTAVRQVRYTASGCEVIAVNTR-STTQTFIYKCDAVLCTLPLGVLKQQ------PPAVQFVPPLPEWKTSAIQRMGFGNLNKVVLCFDRVFWDPS-VNLFGHVGSTTASRGELFLFWNLYKA------------------------PILLALMAGEAA---GIMENISDDVIVGRCLAILKGIFGSSA--VPQPKETVVTRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQ-----------PVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFL 833
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Match: KDM1B (lysine demethylase 1B [Source:NCBI gene;Acc:101172091]) HSP 1 Score: 102.449 bits (254), Expect = 9.316e-22 Identity = 86/344 (25.00%), Postives = 152/344 (44.19%), Query Frame = 3
Query: 1719 FANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGH--SNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
+NLE G+ L+ +S R ++ SG + KG+ L+ L + I N V+ I+YS E + + + N + + A V+ T+PL +L++ N F+PPLP+ K+K+I++LG G+ +K+ L F RFW F + E+RG F FY + +A ++ V+ G A +D+ + ++ + LR++F ++ VPEP +V W+KD +++ +S++ G S + +A + K+FFAGE T+ T+ GA +SG++ AS +
Sbjct: 547 LSNLEFACGSTLDKVSARSWDHNEFFAQFSGDHTLLTKGYYVLLHKLAEALDICT-NCPVQAIDYSGETVKVISSNGSQ-------WTAQKVLVTVPLILLQK--------NLIHFNPPLPERKLKAIHSLGAGIIEKIALQFPCRFWDKKIQGADYFGNIPPVPEKRGMFSVFYDLDPQGK---------------------NAVLMSVISGDAVAAV---RDMEEKDVVNECMKVLRELF--KEQEVPEPVNYFVTHWSKDVWSQMSYSFVKTGGSGEAYDILA----------------------EDVQGKVFFAGEATNRHFPQTVTGAYLSGVREASKM 826
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Match: KDM1B (lysine demethylase 1B [Source:NCBI gene;Acc:101172091]) HSP 1 Score: 93.2041 bits (230), Expect = 4.247e-19 Identity = 79/315 (25.08%), Postives = 139/315 (44.13%), Query Frame = 3
Query: 1806 SGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGH--SNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDI 2744
SG + KG+ L+ L + I N V+ I+YS E + + + N + + A V+ T+PL +L++ N F+PPLP+ K+K+I++LG G+ +K+ L F RFW F + E+RG F FY + +A ++ V+ G A +D+ + ++ + LR++F ++ VPEP +V W+KD +++ +S++ G S + +A + K+FFAGE T+ T+ GA +SG++ AS +
Sbjct: 324 SGDHTLLTKGYYVLLHKLAEALDICT-NCPVQAIDYSGETVKVISSNGSQ-------WTAQKVLVTVPLILLQK--------NLIHFNPPLPERKLKAIHSLGAGIIEKIALQFPCRFWDKKIQGADYFGNIPPVPEKRGMFSVFYDLDPQGK---------------------NAVLMSVISGDAVAAV---RDMEEKDVVNECMKVLRELF--KEQEVPEPVNYFVTHWSKDVWSQMSYSFVKTGGSGEAYDILA----------------------EDVQGKVFFAGEATNRHFPQTVTGAYLSGVREASKM 574
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Match: ENSORLT00000011446.2 (peroxisomal N(1)-acetyl-spermine/spermidine oxidase [Source:NCBI gene;Acc:101169480]) HSP 1 Score: 83.9593 bits (206), Expect = 2.415e-16 Identity = 76/328 (23.17%), Postives = 137/328 (41.77%), Query Frame = 3
Query: 1809 GSEIYIKKGFQALMSTLTKK--STIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQRE---------QRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYT-LDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHY 2756
G + GF+ L+ L + + YN V+ + ++N + + + + AD V+ ++PLG LK+ ++ F PPLP K+ SI LGFG +KV + F E +W I+ + +++ Q+ + + F+ + V+CG A + + + L+++E+ A+ L F + P + RW DP+ G +SY+ +G S D++N+ PLP + G Q ++ FAGE TH + T+ GA+++G + A + HY
Sbjct: 215 GLDCTFPGGFEGLIQKLMSELPDDVVTYNRPVRRVHWNNAECGENPVTVECHDGEKML--ADHVIVSVPLGYLKKECSS-------LFQPPLPLHKLHSIQRLGFGTNNKVFVEFDEPWWDADCEVIYLLWEDEQDAMVDQVSDVQKSWIKKLFGFTVLKPTERYGH---------------------VLCGWIAGHESEYMETLSELEVA-HAITQLIRRFTGNPVITPR--RVLRSRWFSDPWTCGSYSYLGKGCSEQDLDNMMEPLPPR------------GSKSQPL--QVLFAGEATHPSYFSTVHGALLTGRREADRLISHY 495
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Match: SMESG000081184.1 (SMESG000081184.1) HSP 1 Score: 1780.76 bits (4611), Expect = 0.000e+0 Identity = 920/922 (99.78%), Postives = 920/922 (99.78%), Query Frame = 3
Query: 48 MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAXXXXXXXXXXXXXXXXXXXXXXLAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK 2813
MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAEESDSDKSSSDFESDDETSLEELAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHK AVSNAYKKWNDAEEEVKKMKKDS GSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASMLLDQQDMQLMDWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFSKKDSSRDGSEEDSDESSGGEESKQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK
Sbjct: 1 MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAEESDSDKSSSDFESDDETSLEELAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKTAVSNAYKKWNDAEEEVKKMKKDSTGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASMLLDQQDMQLMDWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFSKKDSSRDGSEEDSDESSGGEESKQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK 922
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Match: SMESG000081184.1 (SMESG000081184.1) HSP 1 Score: 1722.98 bits (4461), Expect = 0.000e+0 Identity = 897/922 (97.29%), Postives = 898/922 (97.40%), Query Frame = 3
Query: 48 MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAXXXXXXXXXXXXXXXXXXXXXXLAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKIAVSNAYKKWNDAEEEVKKMKKDSAGSKNDGDAKDELKDINNEANSSSPIVVSTDFRGDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASXXXXXXXXXXXXWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK 2813
MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAEESDSDKSSSDFESDDETSLEELAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHK AVSNAYKKWNDAEEEVKKMKKDS GSKNDGDAK+ GDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASMLLDQQDMQLMDWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFSKKDSSRDGSEEDSDESSGGEESKQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK
Sbjct: 1 MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKEDNTGFAGAEESDSDKSSSDFESDDETSLEELAASICCLPHSELCAEELEMYPWLSNQTENFKNIYLYVRNKACMSWLKDPKVQLTDKSLIHSINTSSCDKFFLDIISSRLCNHQKNEESSSVKTQNRTNGVDKTLKKFDIDAILKDNFYKDNLNKLVHMAIGFLERHGYVNIGQFNKQNESITNGSLCGSGGLPLQVTVIGAGLSGIIAALQLQYFGCKVLVLEAKESPGGRLQTFQQEGWQAEISPFSITGINNPVNQLIKQAGLGVSVMNSDVDIVNTTGDPVSKEAFSRIECELNRLLLAANDICSKFALNTLDKKHVSLGEMLEALLSLQTLHCKNLKKSSNALILKLMNRLQEVINEMEQHKTAVSNAYKKWNDAEEEVKKMKKDSTGSKNDGDAKE----------------------GDTSNEEEDTTDRVEPKRTTIINPAQQMKVNLALSEYRRTFKKCIPFFDEAIKIRKMIKLIQDYDPASMLLDQQDMQLMDWFFANLEMRMGTHLNNLSLRHGGCHDSNVDTSGSEIYIKKGFQALMSTLTKKSTIFQYNTVVKEIEYSNEGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINALGFGMFDKVVLCFKERFWGHSNMKIFAQLKAQREQRGEFMQFYAFSKKDSSRDGSEEDSDESSGGEESKQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHTHSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK 900
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Match: SMESG000050145.1 (SMESG000050145.1) HSP 1 Score: 73.9442 bits (180), Expect = 3.465e-13 Identity = 86/320 (26.88%), Postives = 140/320 (43.75%), Query Frame = 3
Query: 1884 YNTVVKEIEYSN-EGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINAL-----GFGMFDKVVLCFK--ERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHT--HSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSRLPGSLQIRK 2813
YN + K+I+Y N + I++T I+ + D + +K + T+P+GVL N A F P LP+ KIKSI L G +KVVL ++ + FW K LKA + + F++++ ++ S G+ +VC D TD E+ L L+ ++ K +P+P V RW++DP++ G SY P G L T++ R+ + + P++FFAGE T + GA+M+G+ A++I Y P+ P L + P + RK
Sbjct: 292 YNQIAKKIDYRNPDEIIVTCIDP--NTGDLIRYKCKHCIVTVPVGVLARLSN----IAAINFVPTLPEDKIKSIKRLALPSIGAETHNKVVLRYRPSDVFWD----KKVPHLKAN-TGKLHILNFHSYAIIYATPKSKHSFSFAIFPGKPGL--------LVCHIWGGTEIKTIDHTDEEIVDIILTLLQGMYQKLG-TLPKPIQTLVTRWSEDPFSLG--SYTPGGP----------------LSTNDDRKSYARAIPEDGSPRIFFAGEGTLGEFEAKECTHGALMNGMHKAAEIVSFYHPKRPIFLDK-PSNYLKRK 572
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Match: SMESG000050131.1 (SMESG000050131.1) HSP 1 Score: 68.5514 bits (166), Expect = 1.616e-11 Identity = 80/308 (25.97%), Postives = 128/308 (41.56%), Query Frame = 3
Query: 1893 VVKEIEYSN-EGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINAL-----GFGMFDKVVLCFK--ERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHT--HSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSR 2786
+ K+I+Y N + I++T I+ + D + +K + T+P+GVL N A F P LP+ KIKSI L G +KVVL ++ + FW + F+ E + F+ F F K +VC D TD E+ L L+ ++ K +P+P V RW++DP++ G SY P G L T++ R+ + + P++FFAGE T + GA+M+G+ A++I Y P+ P L +
Sbjct: 265 ITKKIDYRNPDEIIVTCIDP--NTGDLIRYKCKHCIVTVPVGVLARLSN----IAAINFVPTLPEDKIKSIKRLALPSIGAETHNKVVLRYRPSDVFW--DKKRFFSNHLCDTEVKA-FVFFCHFPGKPGL--------------------------LVCHIWGGTEIKTIDHTDEEIVDIILTLLQGMYQKLG-TLPKPIQTLVTRWSEDPFSLG--SYTPGGP----------------LSTNDDRKSYARAIPEDGSPRIFFAGEGTLGEFEAKECTHGALMNGMHKAAEIVSFYHPKRPIFLDK 518
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Match: SMESG000050131.1 (SMESG000050131.1) HSP 1 Score: 68.1662 bits (165), Expect = 2.180e-11 Identity = 82/308 (26.62%), Postives = 130/308 (42.21%), Query Frame = 3
Query: 1893 VVKEIEYSN-EGIMITAINTALSEEDPVFFKADVVVSTLPLGVLKESINNPLGTNAPQFSPPLPDWKIKSINAL-----GFGMFDKVVLCFK--ERFWGHSNMKIFAQLKAQREQRGEFMQFYAFXXXXXXXXXXXXXXXXXXXXXXXXQVDATVVGVVCGKAATNYTLDKDLTDVEMGKRALAALRDIFLKRKINVPEPSLIYVYRWTKDPYARGVFSYIPEGASLADVENVAIPLPVQELDTSNQRQRRSGGTVQVAVPKLFFAGEHT--HSASIGTIQGAMMSGLKAASDICKHYFPQLPNILSR 2786
+ K+I+Y N + I++T I+ + D + +K + T+P+GVL N A F P LP+ KIKSI L G +KVVL ++ +RF+ SN ++KA F+ F F K +VC D TD E+ L L+ ++ K +P+P V RW++DP++ G SY P G L T++ R+ + + P++FFAGE T + GA+M+G+ A++I Y P+ P L +
Sbjct: 265 ITKKIDYRNPDEIIVTCIDP--NTGDLIRYKCKHCIVTVPVGVLARLSN----IAAINFVPTLPEDKIKSIKRLALPSIGAETHNKVVLRYRPSDRFF--SNHLCDTEVKA-------FVFFCHFPGKPGL--------------------------LVCHIWGGTEIKTIDHTDEEIVDIILTLLQGMYQKLG-TLPKPIQTLVTRWSEDPFSLG--SYTPGGP----------------LSTNDDRKSYARAIPEDGSPRIFFAGEGTLGEFEAKECTHGALMNGMHKAAEIVSFYHPKRPIFLDK 512 The following BLAST results are available for this feature:
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Lysine-specific histone demethylase 1A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021069 ID=SMED30021069|Name=Lysine-specific histone demethylase 1A|organism=Schmidtea mediterranea sexual|type=transcript|length=3033bpback to top protein sequence of SMED30021069-orf-1 >SMED30021069-orf-1 ID=SMED30021069-orf-1|Name=SMED30021069-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=923bp MSDEEPKSIDYSSEESTKRSNQMDGNDSLPKRPRMNLWEHQNKAQMSTIKback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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