Tyrosine-protein kinase
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30021052 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Homology
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: BTK (Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133]) HSP 1 Score: 379.022 bits (972), Expect = 3.693e-121 Identity = 230/643 (35.77%), Postives = 360/643 (55.99%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVL-----------------NDDLDNKSNVFQIGY---VMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVE---SRNNTVK---------------------------WELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ + +++ S + + Y V+ D G LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ + + S++ S T K EL+ VVALY + P+ LQL KG+ Y +++ S+ WW RD G+ GY+P ++V + ED ++W+ ++R QAE L +EG+EG FIVR SS T+SV K +G + + HY + S +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ V +N++ P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H LV+L+GV K RPI IITEYM +G + ++LR + + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE+++ + PY +N++ ++I G RL +P +++Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGP------LYVFSPTEELRKRWIHQLKNVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGK-YTVSVFAKSTGDPQGVIRHYVVCSTPQSQ-YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG-KMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHE 636
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: BTK (Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133]) HSP 1 Score: 377.867 bits (969), Expect = 2.258e-120 Identity = 229/637 (35.95%), Postives = 360/637 (56.51%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVLNDD-----------LDNKSNVFQIGYVMDDNGGSYNLVV----LYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVE---SRNNTVK---------------------------WELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ + + S + QI +++ + +V LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ + + S++ S T K EL+ VVALY + P+ LQL KG+ Y +++ S+ WW RD G+ GY+P ++V + ED ++W+ ++R QAE L +EG+EG FIVR SS T+SV K +G + + HY + S +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ V +N++ P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H LV+L+GV K RPI IITEYM +G + ++LR + + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE+++ + PY +N++ ++I G RL +P +++Y +M CW
Sbjct: 46 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQIS-IIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGK-YTVSVFAKSTGDPQGVIRHYVVCSTPQSQ-YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG-KMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWH 669
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: ITK (IL2 inducible T cell kinase [Source:HGNC Symbol;Acc:HGNC:6171]) HSP 1 Score: 373.244 bits (957), Expect = 1.851e-119 Identity = 228/609 (37.44%), Postives = 348/609 (57.14%), Query Frame = 3
Query: 129 LKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSS-------VESRNNTVKWELES--VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR---VHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
L ++ +KSQ K+ S +N+K+R FVLT L YF+ + + LK + LS IK +E ++ D+ + V+ DN +LY+ + E R+ W+ LK + ++ P+YHP W+ GK+ CC + + GC ++ N WE E V+ALY + +L L + E Y L+D S WW ++D G GYVP S++ + ++ ++W+ +SR +AE L + G+EG F+VR S T T T+SV TK S + HY I++ + +Y++EK+++ S+ LI YH+HN GGLV RLR V + P++ G+ ++ +D ++L + IG GQFG+V G + N +VA+K + EG M+EEDFI+EA M L+HP LV+L+GV L+ PI ++ E+M+HG + D+LR + + L C V +GMAYL++ +HRDLAARNCLV + +KV+DFGM RF+LD+ Y SS GTKFPV+WA+PEVF + Y++++DVWSFG+LMWEVF+ + PY +SN++V + I G RL KP +Y +M CW+
Sbjct: 6 LLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE-IVKSDISIPCHYKYPFQVVHDN------YLLYVFAPDRESRQRWVLALKEETRNNNSLV-PKYHPNFWMD-GKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGT-YTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQE-IGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF--AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE----NQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG-KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWK 596
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: TEC (tec protein tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11719]) HSP 1 Score: 372.859 bits (956), Expect = 3.166e-119 Identity = 230/614 (37.46%), Postives = 350/614 (57.00%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDD-LDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSV--------ESRNNTVKWEL---------ESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTK--QSGSLRVHHYRIRQQGVS-GPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+ ++SQ KK S NYK R FVLT L Y++ + + K +++S IK +E V NDD + N + V D N LYI + + R+ W++ LK K + +YHP W G Y CC + + GCE +SS+ E++ + E VVA+Y F + L+L +G+ Y +++ + WW RD YG GY+P ++V ++ ++ ++W+ +++R +AE L E +EG F+VR SS GL T+S+ TK GS HY I++ S +YL+EKH + S+ E+IEYHKHNA GLV RLR V + ++ P + G +++E++ ++L + +G G FGVV+ G++R +VA+K + EG M EEDFI+EA+ M L HP LV+L+GV + +PI I+TE+M+ G + +FLR + +L C V +GM YL++ +F+HRDLAARNCLV VKV+DFGMAR++LD+ Y SS+G KFPV+W PEVF + +++++DVWSFG+LMWEVFT + P+ +N +V + G RL +P + +Y +ML CWQ
Sbjct: 11 LIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYR-KGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDAN-------TLYIFAPSPQSRDLWVKKLKEEIKNNNNIM-IKYHPKFWT-DGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSS--QPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF--SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG----VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEG-RMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQE 604
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Match: TXK (TXK tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12434]) HSP 1 Score: 331.643 bits (849), Expect = 1.131e-104 Identity = 176/428 (41.12%), Postives = 272/428 (63.55%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCN---HDWFYGDVSRQQAESQLYEEGREGCFIVRCS-STGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDC-PISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
V ALY F P + L L + E Y +++ +P WW RD G G +P ++V E+ N ++W++ +++R QAE L +E +EG FIVR S G +++ + ++S + HY+I++ SG +Y++E+H + S+ ELI YH+HNA GL+ RLR C P + G +++E+D ++L K IG GQFGVV GE+R ++QVA+K + EG M+EEDFI+EA+ M L+H LV+L+GV ++ +P+ I+TE+M++G + ++LR N + + +L C + +GM YL++ ++HRDLAARNCLV S + VK++DFGM R++LD+ Y SS G KFP++W+ PEVF Y++++DVWSFG+LMWEVFT + P+ +SN QV + I G RL +P P +Y +M CW
Sbjct: 87 VKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVT-ENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKND-SGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKE-IGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKL--RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS----TCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEG-KMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 265.003 bits (676), Expect = 2.105e-80 Identity = 160/435 (36.78%), Postives = 249/435 (57.24%), Query Frame = 3
Query: 627 ELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR-DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQ-LYEEGREGCFIVRC--SSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLD---EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLL-DNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLY-VLMLECW 1898
E E++VALY + G L KG+ L+D S+ DWWY+R G+ GYVPR+ V ++ + +W+ G + R +AE L +G F++R + T + LT+ Q V HY+I++ ++++ + + S+ EL+ Y+ GL +L + P+ R P + D +E+ N L L K +G G FG V G++R + +VA+K M G M+ E F+ EA+ M+ +HPNLV+L+ V + P IITEYM +GS+ +LR + + ++ L D AQ+A GM YL++R VHRDLAARN LV VKVADFG+AR L+ +++YE+ G KFP++W APE +T ++DVWS+GIL++E+ T Q PY G N +V + + G R+ P CP+++Y ++L+CW
Sbjct: 16 ERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPA-PRLAPTRPDLSHDTQQNWEIPRNQLHL-KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA--LVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKG-QVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 444
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 264.618 bits (675), Expect = 1.267e-79 Identity = 160/435 (36.78%), Postives = 249/435 (57.24%), Query Frame = 3
Query: 627 ELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR-DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQ-LYEEGREGCFIVRC--SSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLD---EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLL-DNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLY-VLMLECW 1898
E E++VALY + G L KG+ L+D S+ DWWY+R G+ GYVPR+ V ++ + +W+ G + R +AE L +G F++R + T + LT+ Q V HY+I++ ++++ + + S+ EL+ Y+ GL +L + P+ R P + D +E+ N L L K +G G FG V G++R + +VA+K M G M+ E F+ EA+ M+ +HPNLV+L+ V + P IITEYM +GS+ +LR + + ++ L D AQ+A GM YL++R VHRDLAARN LV VKVADFG+AR L+ +++YE+ G KFP++W APE +T ++DVWS+GIL++E+ T Q PY G N +V + + G R+ P CP+++Y ++L+CW
Sbjct: 72 ERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPA-PRLAPTRPDLSHDTQQNWEIPRNQLHL-KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA--LVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKG-QVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 500
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 264.618 bits (675), Expect = 1.267e-79 Identity = 160/435 (36.78%), Postives = 249/435 (57.24%), Query Frame = 3
Query: 627 ELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR-DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQ-LYEEGREGCFIVRC--SSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLD---EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLL-DNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLY-VLMLECW 1898
E E++VALY + G L KG+ L+D S+ DWWY+R G+ GYVPR+ V ++ + +W+ G + R +AE L +G F++R + T + LT+ Q V HY+I++ ++++ + + S+ EL+ Y+ GL +L + P+ R P + D +E+ N L L K +G G FG V G++R + +VA+K M G M+ E F+ EA+ M+ +HPNLV+L+ V + P IITEYM +GS+ +LR + + ++ L D AQ+A GM YL++R VHRDLAARN LV VKVADFG+AR L+ +++YE+ G KFP++W APE +T ++DVWS+GIL++E+ T Q PY G N +V + + G R+ P CP+++Y ++L+CW
Sbjct: 72 ERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPA-PRLAPTRPDLSHDTQQNWEIPRNQLHL-KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA--LVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKG-QVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 500
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 264.618 bits (675), Expect = 1.572e-79 Identity = 160/435 (36.78%), Postives = 249/435 (57.24%), Query Frame = 3
Query: 627 ELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR-DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQ-LYEEGREGCFIVRC--SSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLD---EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLL-DNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLY-VLMLECW 1898
E E++VALY + G L KG+ L+D S+ DWWY+R G+ GYVPR+ V ++ + +W+ G + R +AE L +G F++R + T + LT+ Q V HY+I++ ++++ + + S+ EL+ Y+ GL +L + P+ R P + D +E+ N L L K +G G FG V G++R + +VA+K M G M+ E F+ EA+ M+ +HPNLV+L+ V + P IITEYM +GS+ +LR + + ++ L D AQ+A GM YL++R VHRDLAARN LV VKVADFG+AR L+ +++YE+ G KFP++W APE +T ++DVWS+GIL++E+ T Q PY G N +V + + G R+ P CP+++Y ++L+CW
Sbjct: 76 ERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPA-PRLAPTRPDLSHDTQQNWEIPRNQLHL-KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA--LVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKG-QVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 504
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 264.618 bits (675), Expect = 1.572e-79 Identity = 160/435 (36.78%), Postives = 249/435 (57.24%), Query Frame = 3
Query: 627 ELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR-DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQ-LYEEGREGCFIVRC--SSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLD---EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLL-DNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLY-VLMLECW 1898
E E++VALY + G L KG+ L+D S+ DWWY+R G+ GYVPR+ V ++ + +W+ G + R +AE L +G F++R + T + LT+ Q V HY+I++ ++++ + + S+ EL+ Y+ GL +L + P+ R P + D +E+ N L L K +G G FG V G++R + +VA+K M G M+ E F+ EA+ M+ +HPNLV+L+ V + P IITEYM +GS+ +LR + + ++ L D AQ+A GM YL++R VHRDLAARN LV VKVADFG+AR L+ +++YE+ G KFP++W APE +T ++DVWS+GIL++E+ T Q PY G N +V + + G R+ P CP+++Y ++L+CW
Sbjct: 76 ERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQL-TFPA-PRLAPTRPDLSHDTQQNWEIPRNQLHL-KRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGIQA--LVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKG-QVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCW 504
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330693) HSP 1 Score: 379.407 bits (973), Expect = 3.393e-124 Identity = 202/427 (47.31%), Postives = 282/427 (66.04%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 25 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELML-MEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 440
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0330692) HSP 1 Score: 381.333 bits (978), Expect = 1.410e-123 Identity = 202/427 (47.31%), Postives = 283/427 (66.28%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L + +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 126 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELMLMEE-LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 541
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0112835) HSP 1 Score: 381.333 bits (978), Expect = 4.744e-123 Identity = 202/427 (47.31%), Postives = 283/427 (66.28%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L + +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 164 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELMLMEE-LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 579
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0079618) HSP 1 Score: 381.333 bits (978), Expect = 4.744e-123 Identity = 202/427 (47.31%), Postives = 283/427 (66.28%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L + +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 164 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELMLMEE-LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 579
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Match: Btk29A (gene:FBgn0003502 transcript:FBtr0079615) HSP 1 Score: 381.333 bits (978), Expect = 4.744e-123 Identity = 202/427 (47.31%), Postives = 283/427 (66.28%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L + +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 164 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELMLMEE-LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 579
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: itk (IL2 inducible T cell kinase [Source:ZFIN;Acc:ZDB-GENE-990415-261]) HSP 1 Score: 387.882 bits (995), Expect = 2.849e-125 Identity = 232/605 (38.35%), Postives = 354/605 (58.51%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDS-----SVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGS-----LRVHHYRIRQQ--GVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGV---GLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+Y+KSQ K+ S NYK R F+L L YF+ + K + LS IK +E V +D + + D SY L V ++C R W++ LK IQ +YHP W GK+ CC+ + + GC N + + + + + E VVAL +FTP + L L K E Y ++DCS P+WW ++D G +G VP +V + ++ +W+ D++R +AE L +E ++G F+VR S T+S+ T+ SGS +V HY+I+ Q G +YL+EK+L+P++ ELI YH+HN GL+ RLR SRN P S + D++E+ ++++L +G GQFG+V +G +++M+VAVK + EG M+EE+F +EA+ M L+H LV+L+GVV + PI ++ E+M++G + +FLRA + K+ L + C V++GMAYL+ NF+HRDLAARNCLV + VK+ADFGM RF+LD+ Y SS G+KFPVRW++PEV + Y++++DVWSFG+ MWEV++ + PY+ +SN++V + + G RL KP CP +Y LM W+
Sbjct: 11 LYKKSQQKRRTSPCNYKERTFILNTQDLAYFEQRPGKKPTQKGCIELSHIKCVEIVRSDVPIPCDYKYPFQIIHD----SYYLYVFAPDNDC---RLKWVKALK--EAIQNNSLFLKYHPDFWGE-GKWRCCQQTEKLATGCSEYYPNGAKPLPPTPDPSRRSSEPEERIVVALRNFTPKEHTDLPLQKDEEYFIVDCSEPNWWTVKDKDGNVGSVPCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLMQENKDGGFMVRNSKHAGV-YTVSIFTRVSGSNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRLRHCVSRN--VPNSARIKELSSDKWEIHPDEVKLS-VELGSGQFGLVWKGSWQDMEVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGKLSQKA--LLEMCLDVSEGMAYLESSNFIHRDLAARNCLVS----ENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSE-GRTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKE 594
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: itk (IL2 inducible T cell kinase [Source:ZFIN;Acc:ZDB-GENE-990415-261]) HSP 1 Score: 372.089 bits (954), Expect = 1.199e-119 Identity = 229/606 (37.79%), Postives = 350/606 (57.76%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDS-----SVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGS-----LRVHHYRIRQQ--GVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGV---GLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQHV 1907
+Y+KSQ K+ S NYK R F+L L YF+ G DR I+ L +L + ++ D SY L V ++C R W++ LK IQ +YHP W GK+ CC+ + + GC N + + + + + E VVAL +F P + L L K E Y ++DCS P+WW ++D G +G VP +V + ++ +W+ D++R +AE L +E ++G F+VR S T+S+ T+ SGS +V HY+I+ Q G +YL+EK+L+P++ ELI YH+HN GL+ RLR SRN P S + D++E+ ++++L +G GQFG+V +G +++ +VAVK + EG M+EE+F +EA+ M L+H LV+L+GVV + PI ++ E+M++G + +FLRA + K+ L + C V++GMAYL+ NF+HRDLAARNCLV + VK+ADFGM RF+LD+ Y SS G+KFPVRW++PEV + Y++++DVWSFG+ MWEV++ + PY+ +SN++V + + G RL KP CP +Y LM W+ V
Sbjct: 11 LYKKSQQKRRTSPCNYKERTFILNTQDLAYFE---QRPGDNFDR------NCIQNCLKVEL--------VNLIIHD---SYYLYVFAPDNDC---RLKWVKALK--EAIQNNSLFLKYHPDFWGE-GKWRCCQQTEKLATGCSEYYPNGAKPLPPTPDPSRRSSEPEERIVVALRNFIPKEHTDLPLQKDEEYFIVDCSEPNWWTVKDKDGNVGSVPCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLMQENKDGGFMVRNSKHAGV-YTVSIFTRVSGSNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRLRHCVSRN--VPNSARIKELSSDKWEIHPDEVKLS-VELGSGQFGLVWKGSWQDREVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGKLSQKA--LLEMCLDVSEGMAYLESSNFIHRDLAARNCLVS----ENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSEG-RTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKEV 579
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: itk (IL2 inducible T cell kinase [Source:ZFIN;Acc:ZDB-GENE-990415-261]) HSP 1 Score: 372.089 bits (954), Expect = 2.211e-119 Identity = 225/608 (37.01%), Postives = 350/608 (57.57%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDI---SNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDS-----SVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGS-----LRVHHYRIRQQ--GVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGV---GLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+Y+KSQ K+ S NYK R F+L L YF+ N R +++ L + + + +++D SY L V ++C R W++ LK IQ +YHP W GK+ CC+ + + GC N + + + + + E VVAL +F P + L L K E Y ++DCS P+WW ++D G +G VP +V + ++ +W+ D++R +AE L +E ++G F+VR S T+S+ T+ SGS +V HY+I+ Q G +YL+EK+L+P++ ELI YH+HN GL+ RLR SRN P S + D++E+ ++++L +G GQFG+V +G +++ +VAVK + EG M+EE+F +EA+ M L+H LV+L+GVV + PI ++ E+M++G + +FLRA + K+ L + C V++GMAYL+ NF+HRDLAARNCLV + VK+ADFGM RF+LD+ Y SS G+KFPVRW++PEV + Y++++DVWSFG+ MWEV++ + PY+ +SN++V + + G RL KP CP +Y LM W+
Sbjct: 11 LYKKSQQKRRTSPCNYKERTFILNTQDLAYFEQRPGDNFDRNCIQNCLKVELVYLVVIIIHD--------------------SYYLYVFAPDNDC---RLKWVKALK--EAIQNNSLFLKYHPDFWGE-GKWRCCQQTEKLATGCSEYYPNGAKPLPPTPDPSRRSSEPEERIVVALRNFIPKEHTDLPLQKDEEYFIVDCSEPNWWTVKDKDGNVGSVPCIYVTEKLSNNIEKFEWYNKDINRTEAEDLLMQENKDGGFMVRNSKHAGV-YTVSIFTRVSGSNGEKCPQVKHYQIKVQSEGEKVLYYLAEKYLFPTIPELIRYHQHNPAGLITRLRHCVSRN--VPNSARIKELSSDKWEIHPDEVKLS-VELGSGQFGLVWKGSWQDREVAVKTVREGFMSEEEFKEEAQVMMKLSHNRLVQLYGVVTQRSPIYLVFEFMENGCLTEFLRAKKGKLSQKA--LLEMCLDVSEGMAYLESSNFIHRDLAARNCLVS----ENSVVKIADFGMTRFVLDDQYTSSHGSKFPVRWSSPEVIKFGKYSSKSDVWSFGVFMWEVYSEG-RTPYDNRSNSEVVETLNAGHRLLKPRLCPQSVYELMQWSWKE 581
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: btk (Bruton agammaglobulinemia tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070531-1]) HSP 1 Score: 372.474 bits (955), Expect = 4.194e-119 Identity = 228/625 (36.48%), Postives = 351/625 (56.16%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYFD--ISNNARGKLKDRLNLSSIKFIEKVLNDDL--DNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSV---ESRNNTVKWELE--------------------------SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSH-VQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSG--SLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPS-RNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGI-LSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R FVLT + Y+D R LK +++ I+ +E VL +D ++ FQI Y D G LY+ + D+ R+ WI LK + + Q +YHP W G + CC + +MGC ++ + + V S+N + L +V+A Y + P+ T L+L K E YTL++ S P+W+ +D YG+ GY+P ++ VQ + +DW+ +++R QAE+ L E ++G F+VR S T+SV TK G S HY I G FYL+EKH + ++ ELI YH+HNA GLV RL+ + S R ++ P + G+G +E+D L + +G GQFGVVK G+++ VA+K + EG M+E+DFI+EA+ M L H NLV+L+GV K RPI I+TEY+ +G + ++L+ N + I L + C V++GM YL+ F+HRDLAARNCLV S + +KV DFG++R++LD+ Y SS G+KFPVRW+ PEV +++++D+W+FG+LMWE++T + PY+ +N ++ + I G RL +P + ++ +M CW
Sbjct: 12 KRSQQKKKTSPLNFKERLFVLTHDKISYYDYDAEKAKRKSLKGYVDIEKIRCVEVVLPEDSAPPDRHYPFQIVY---DEGP------LYVFAKSDQIRKHWIHELKNVVRFNKDLMQ-KYHPCFW-EDGVWKCCLQEVKQAMGCRVLETKNGGVFKRGSKNRDSRKPLPPTPEEEKPARPLPPEPPMPPAFSIGMTVIAEYEYAPMTTNDLELRKDEEYTLLEISDPNWFKAKDKYGKEGYIPSNYIVQALNGLEKYDWYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRHYNILLTA-DGQFYLAEKHNFTNIPELINYHQHNAAGLVSRLKYIVSNRAQNAPCTAGLGYGSWEIDPRQLTFIRE-LGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQEGL---LNPTSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDS----NGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQG-RMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHE 615
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Match: BX544890.1 (Bruton agammaglobulinemia tyrosine kinase [Source:NCBI gene;Acc:568653]) HSP 1 Score: 354.755 bits (909), Expect = 1.303e-112 Identity = 221/623 (35.47%), Postives = 339/623 (54.41%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYFD--ISNNARGKLKDRLNLSSIKFIEKVLNDDL--DNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSV---ESRNNTVKWELE--------------------------SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSG--SLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPS-RNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R FVLT + Y+D R LK +++ I+ +E VL +D ++ FQI Y D G LY+ + D+ R+ WI LK + + Q +YHP W G + CC + +MGC ++ + + V S+N + L +V+A Y + P+ T L+L K E YTL++ S P+W+ +D YG W+ +++R QAE+ L E ++G F+VR S T+SV TK G S HY I G FYL+EKH + ++ ELI YH+HNA GLV RL+ + S R ++ P + G+G +E+D L + +G GQFGVVK G+++ VA+K + EG M+E+DFI+EA+ M L H NLV+L+GV K RPI I+TEY+ +G + ++L+ + S +L + C V++GM YL+ F+HRDLAARNCLV S + +KV DFG++R++LD+ Y SS G+KFPVRW+ PEV +++++D+W+FG+LMWE++T + PY+ +N ++ + I G RL +P + ++ +M CW
Sbjct: 12 KRSQQKKKTSPLNFKERLFVLTHDKISYYDYDAEKAKRKSLKGYVDIEKIRCVEVVLPEDSAPPDRHYPFQIVY---DEGP------LYVFAKSDQIRKHWIHELKNVVRFNKDLMQ-KYHPCFW-EDGVWKCCLQEVKQAMGCRVLETKNGGVFKRGSKNRDSRKPLPPTPEEEKPARPLPPEPPMPPAFSIGMTVIAEYEYAPMTTNDLELRKDEEYTLLEISDPNWFKAKDKYG--------------------WYCKNINRSQAENLLKTENKDGGFLVRDSGKFTGKYTVSVFTKAGGETSGSCRHYNILLTA-DGQFYLAEKHNFTNIPELINYHQHNAAGLVSRLKYIVSNRAQNAPCTAGLGYGSWEIDPRQLTFIRE-LGNGQFGVVKYGKWQGRHDVAIKMVKEGSMSEDDFIEEAKVMMKLCHGNLVQLYGVCTKQRPIYIVTEYLANGCLLNYLQERLSN--PTSIVLLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDS----NGTIKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQG-RMPYDRWNNTEIVEKISAGHRLYRPQMANENVFAIMNSCWHE 594
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: TEC (tec protein tyrosine kinase [Source:NCBI gene;Acc:100491653]) HSP 1 Score: 393.275 bits (1009), Expect = 5.253e-127 Identity = 235/629 (37.36%), Postives = 358/629 (56.92%), Query Frame = 3
Query: 105 IEMNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLD---NKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE------------LVISNDSSVESRNNTVKWEL-------ESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQ--SGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
+EMN + L+ S + ++SQ KK S NYK R FVLT L Y++ + K K ++++ +K +E V N + FQI Y + LY+ + E R W++L+K K + +YHP W G Y CC + + GCE L + D+ + E+V+A++ F P++ L+LV GE Y +++ WW R+ YG+ GY+P ++V ++ D+ ++W+ +++R +AE L E +EG FIVR SS GL T+S+ TK GS + HY I++ +YL+EKH++ ++ E+IEYHKHNA GLV RLR V S+N+ P + G D++E++ ++L K +G G FGVV+ G++R +VA+K + EG M+EEDFI+EA+ M L H LV+L+GV + RPI I+TE+M+HG + ++LR ++ IL C V + M+YL+Q NF+HRDLAARNCLV VKV+DFGM R++LD+ Y SS G KFPV+W+ PEVF + +++++DVWSFG+LMWEVFT + P+ SN +V + + G RL +P +Y +M+ CW
Sbjct: 12 VEMNSDIILEES-LIKRSQQKKRTSPLNYKERVFVLTKSRLTYYEGRPEKKNK-KGSVDITKVKCVEFVKNGSENIPCQYKYAFQIVYESN---------TLYVFAPTAESRFKWVKLIKEEVKNN-SFIMSKYHPQFWAD-GVYQCCRQTEKLAPGCEEYNLFGDITKKPLPPTPDAIRARPPPPRPPDPEPEDNGEETVIAMFDFHPVEPHDLRLVTGEEYFVLEKKDAHWWKARNTYGQQGYIPSNYVTEKKLDNLYQYEWYSRNMNRSKAEQLLKSEDKEGGFIVRNSS--QAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQF--SPDILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAG----VVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEG-KMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWH 617
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: TEC (tec protein tyrosine kinase [Source:NCBI gene;Acc:100491653]) HSP 1 Score: 376.711 bits (966), Expect = 6.500e-121 Identity = 228/625 (36.48%), Postives = 353/625 (56.48%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVF-QPRYHPGVWIRPGKYSCCEDGYRWSMGCE------------LVISNDSSVESRNNTVKWEL-------ESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQ--SGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
MN + L+ S + ++SQ KK S NYK R FVLT L Y++ + K K ++++ +K +E V N +++ Q Y ++ ++ + L ++ QL +F +YHP W G Y CC + + GCE L + D+ + E+V+A++ F P++ L+LV GE Y +++ WW R+ YG+ GY+P ++V ++ D+ ++W+ +++R +AE L E +EG FIVR SS GL T+S+ TK GS + HY I++ +YL+EKH++ ++ E+IEYHKHNA GLV RLR V S+N+ P + G D++E++ ++L K +G G FGVV+ G++R +VA+K + EG M+EEDFI+EA+ M L H LV+L+GV + RPI I+TE+M+HG + ++LR ++ IL C V + M+YL+Q NF+HRDLAARNCLV VKV+DFGM R++LD+ Y SS G KFPV+W+ PEVF + +++++DVWSFG+LMWEVFT + P+ SN +V + + G RL +P +Y +M+ CW
Sbjct: 1 MNSDIILEES-LIKRSQQKKRTSPLNYKERVFVLTKSRLTYYEGRPEKKNK-KGSVDITKVKCVEFVKNG---SENIPCQYKY-------AFQIIAFFFT-------------LYVFYSQQLHIFIMSKYHPQFWAD-GVYQCCRQTEKLAPGCEEYNLFGDITKKPLPPTPDAIRARPPPPRPPDPEPEDNGEETVIAMFDFHPVEPHDLRLVTGEEYFVLEKKDAHWWKARNTYGQQGYIPSNYVTEKKLDNLYQYEWYSRNMNRSKAEQLLKSEDKEGGFIVRNSS--QAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQF--SPDILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAG----VVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEG-KMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWH 589
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: npnt (nephronectin [Source:Xenbase;Acc:XB-GENE-952278]) HSP 1 Score: 362.844 bits (930), Expect = 3.176e-115 Identity = 235/634 (37.07%), Postives = 347/634 (54.73%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVL-------------NDDLDNKSNV--------FQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE-------LVISNDSSVESRNN---------------TVKWELESVVALYSFTPIQTGQLQLVKGERYTLID--CSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
++SQ K+ S N+K R FVLT + Y+ D RG K ++L + +E V ++ D + FQI Y D+G LY+ + +E R+ WI LK + V Q +YHP + + G+Y CC + +MGC+ + + S SR T L VVA+Y FTP+ L L KGE Y L++ +P W RD G GY+P ++V + +D ++W+ +++R QAE L E +EG FIVR SS T+SV K SG + HY + + +YL+EKHL+ S+ ELI YH+HNA GL+ RL+ V S + P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H NLV+L+GV K RPI IITE++ +G + ++L+ G L C+ V M YL+ + ++HRDLAARNCLV + VKV+DFG++R++LD+ Y SS G+KFPVRW++PEV +++++DVWSFG+LMWEVFT + PY+ +N ++ + I G RL +P N DR+Y +M+ CW
Sbjct: 14 KRSQQKRKTSPLNFKKRLFVLTDTKIIYYEYDFDRGRRGSKKGSVDLDKVICVECVEPEENPPPERQIPNREEFDTEQMTIIERFPYPFQIVY---DDGP------LYVFAPTEELRKRWIHQLKHVIRFNSDVAQ-KYHPRFY-QDGQYLCCAQTAKNAMGCQPLGNANGFIRTERSQRRSRKPLPPPPPQESQKPLPPTPCLSLHKVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNP-WLRARDKNGLEGYIPGNYVTEAQDPLEIYEWYSKNMTRSQAEKLLRAEDKEGGFIVRDSSKAGK-YTVSVYAKSSGEGIIRHYVV-CEAPGNQYYLAEKHLYSSIPELITYHQHNAAGLISRLKYPVCSLRKTAPSTAGLGYGSWEIDPKDLTFLKE-LGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDEFIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGRV--SQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAA----DGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLG-RMPYDRFTNNEIVEQITRGVRLYRPQNATDRVYSIMVSCW 625
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: TEC (tec protein tyrosine kinase [Source:NCBI gene;Acc:100491653]) HSP 1 Score: 360.918 bits (925), Expect = 9.096e-115 Identity = 230/638 (36.05%), Postives = 342/638 (53.61%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLD---NKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE------------LVISNDS-SVESRNNTVKWEL-----------------ESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDF--CNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQ--SGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
MN + L+ S + ++SQ KK S NYK R FVLT L Y++ + K K ++++ +K +E V N + FQI Y + LY+ + E R W++L+K K + +YHP W G Y CC + + GCE L + D+ V + W E+V+A++ F P++ L+LV GE Y +++ WW R+ YG+ GY+P + CN+ +EG FIVR SS GL T+S+ TK GS + HY I++ +YL+EKH++ ++ E+IEYHKHNA GLV RLR V S+N+ P + G D++E++ ++L K +G G FGVV+ G++R +VA+K + EG M+EEDFI+EA+ M L H LV+L+GV + RPI I+TE+M+HG + ++LR ++ IL C V + M+YL+Q NF+HRDLAARNCLV VKV+DFGM R++LD+ Y SS G KFPV+W+ PEVF + +++++DVWSFG+LMWEVFT + P+ SN +V + + G RL +P +Y +M+ CW
Sbjct: 1 MNSDIILEES-LIKRSQQKKRTSPLNYKERVFVLTKSRLTYYEGRPEKKNK-KGSVDITKVKCVEFVKNGSENIPCQYKYAFQIVYESN---------TLYVFAPTAESRFKWVKLIKEEVKNN-SFIMSKYHPQFWAD-GVYQCCRQTEKLAPGCEEYNLFGDITKKPLPPTPDAIRVRIIQVSKTWIARPPPPRPPDPEPEDNGEETVIAMFDFHPVEPHDLRLVTGEEYFVLEKKDAHWWKARNTYGQQGYIPICFNIEHNTMIICNNT----------------SSDKEGGFIVRNSS--QAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSYDKWEINPSELTFMKE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQF--SPDILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAG----VVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEG-KMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWH 599
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Match: npnt (nephronectin [Source:Xenbase;Acc:XB-GENE-952278]) HSP 1 Score: 352.443 bits (903), Expect = 7.021e-112 Identity = 225/604 (37.25%), Postives = 338/604 (55.96%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLID--CSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
M + S ++SQ K+ S N+K R FVLT + Y+ D RG K ++L + +E V ++ QI V DD LY+ + +E R+ WI LK + V Q +YHP + + G+Y CC + +MGC+ + + + T L VVA+Y FTP+ L L KGE Y L++ +P W RD G GY+P ++V D ++ + + ++++ +EG FIVR SS T+SV K SG + HY + + +YL+EKHL+ S+ ELI YH+HNA GL+ RL+ V S + P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H NLV+L+GV K RPI IITE++ +G + ++L+ G L C+ V M YL+ + ++HRDLAARNCLV + VKV+DFG++R++LD+ Y SS G+KFPVRW++PEV +++++DVWSFG+LMWEVFT + PY+ +N ++ + I G RL +P N DR+Y +M+ CW+
Sbjct: 1 MAATASILESIFLKRSQQKRKTSPLNFKKRLFVLTDTKIIYYEYDFDRGRRGSKKGSVDLDKVICVECVEPEENPPPER--QIPIVYDDGP-------LYVFAPTEELRKRWIHQLKHVIRFNSDVAQ-KYHPRFY-QDGQYLCCAQTAKNAMGCQPLGN-----KPLPPTPCLSLHKVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNP-WLRARDKNGLEGYIPGNYVTEAQDPL-------EIYEASSWTPVFQD-KEGGFIVRDSSKAGK-YTVSVYAKSSGEGIIRHYVV-CEAPGNQYYLAEKHLYSSIPELITYHQHNAAGLISRLKYPVCSLRKTAPSTAGLGYGSWEIDPKDLTFLKE-LGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDEFIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGRV--SQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAA----DGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLG-RMPYDRFTNNEIVEQITRGVRLYRPQNATDRVYSIMVSCWK 569
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Btk (Bruton agammaglobulinemia tyrosine kinase [Source:MGI Symbol;Acc:MGI:88216]) HSP 1 Score: 382.489 bits (981), Expect = 1.218e-122 Identity = 230/638 (36.05%), Postives = 360/638 (56.43%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVLNDDL-----------DNKSNVFQIGYVMDDNGGSYNLVV----LYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVE---SRNNTVK---------------------------WELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ + + S + QI +++ + +V LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ + + S++ S T K EL+ VVALY + P+ LQL KGE Y +++ S+ WW RD G+ GY+P +++ + ED ++W+ ++R QAE L +EG+EG FIVR SS T+SV K +G + + HY + S +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ V +N++ P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H LV+L+GV K RPI IITEYM +G + ++LR + + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE+++ + PY +N++ ++I G RL +P +R+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVIPEKNPPPERQIPRRGEESSEMEQIS-IIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTTELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGK-YTVSVFAKSTGEPQGVIRHYVVCSTPQSQ-YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG-KMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHE 636
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Tec (tec protein tyrosine kinase [Source:MGI Symbol;Acc:MGI:98662]) HSP 1 Score: 378.252 bits (970), Expect = 1.765e-121 Identity = 231/613 (37.68%), Postives = 346/613 (56.44%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDD-LDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVES----------------RNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTK--QSGSLRVHHYRIRQQGVS-GPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+ ++SQ KK S NYK R FVLT L Y++ + + K +++S IK +E V NDD + N F V D N LYI + + R+ W++ LK K + +YHP W G Y CC + + GCE +SS+ + E VVA+Y F + L+L +G+ Y +++ + WW RD YG GY+P ++V ++ ++ ++W+ + +R +AE L E +EG F+VR SS GL T+S+ TK GS HY I++ S +YL+EKH + S+ E+IEYHKHNA GLV RLR V ++ ++ P + G D++E++ ++L + +G G FGVV+ G++R +VA+K + EG M EEDFI+EA+ M L HP LV+L+GV + +PI I+TE+M+ G + +FLR + +L C V +GM YL++ +F+HRDLAARNCLV VKV+DFGMAR++LD+ Y SS+G KFPV+W PEVF + +++++DVWSFG+LMWE+FT + P+ +N +V + G RL +P LY +ML CWQ
Sbjct: 11 LIKRSQQKKKTSPLNYKERLFVLTKSVLSYYEGRAEKKYR-KGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDAN-------TLYIFAPSPQSRDRWVKKLKEEIKNNNNIM-IKYHPKFWA-DGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSS--QPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF--SRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG----VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEG-RMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQE 603
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Tec (tec protein tyrosine kinase [Source:MGI Symbol;Acc:MGI:98662]) HSP 1 Score: 378.252 bits (970), Expect = 1.765e-121 Identity = 231/613 (37.68%), Postives = 346/613 (56.44%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDD-LDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVES----------------RNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTK--QSGSLRVHHYRIRQQGVS-GPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+ ++SQ KK S NYK R FVLT L Y++ + + K +++S IK +E V NDD + N F V D N LYI + + R+ W++ LK K + +YHP W G Y CC + + GCE +SS+ + E VVA+Y F + L+L +G+ Y +++ + WW RD YG GY+P ++V ++ ++ ++W+ + +R +AE L E +EG F+VR SS GL T+S+ TK GS HY I++ S +YL+EKH + S+ E+IEYHKHNA GLV RLR V ++ ++ P + G D++E++ ++L + +G G FGVV+ G++R +VA+K + EG M EEDFI+EA+ M L HP LV+L+GV + +PI I+TE+M+ G + +FLR + +L C V +GM YL++ +F+HRDLAARNCLV VKV+DFGMAR++LD+ Y SS+G KFPV+W PEVF + +++++DVWSFG+LMWE+FT + P+ +N +V + G RL +P LY +ML CWQ
Sbjct: 11 LIKRSQQKKKTSPLNYKERLFVLTKSVLSYYEGRAEKKYR-KGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDAN-------TLYIFAPSPQSRDRWVKKLKEEIKNNNNIM-IKYHPKFWA-DGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYGSEGYIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSS--QPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF--SRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG----VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEG-RMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQE 603
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Itk (IL2 inducible T cell kinase [Source:MGI Symbol;Acc:MGI:96621]) HSP 1 Score: 361.688 bits (927), Expect = 3.815e-115 Identity = 223/608 (36.68%), Postives = 352/608 (57.89%), Query Frame = 3
Query: 129 LKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSV---------ESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQ--SGSLRVHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
L ++ +KSQ K+ S +N+K+R FVLT L YF+ + + LK + LS IK +E ++ D+ + V+ DN +LY+ + E R+ W+ LK + ++ +YHP W+ G++ CC + ++GC + ++ ++R + + E V+ALY + +L L E Y L+D S WW ++D G GY P S++ + ++ ++W+ +SR +AE L + G+EG F+VR S T T T+SV TK S + + HY I++ S +Y++EK+++ S+ LI+YH++N GGLV RLR V S + P++ G+ ++ + ++L + IG GQFG+V G + N +VA+K + EG M+EEDFI+EA M L+HP LV+L+GV L+ PI ++ E+M+HG + D+LR+ + + L C V +GMAYL++ +HRDLAARNCLV + +KV+DFGM RF+LD+ Y SS GTKFPV+WA+PEVF + Y++++DVWSFG+LMWEVF+ + PY +SN++V + I G RL KP +Y +M CW+
Sbjct: 6 LLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE-IVKSDISIPCHYKYPFQVVHDN------YLLYVFAPDCESRQRWVLTLKEETRNNNSLVS-KYHPNFWMD-GRWRCCSQLEKPAVGCAPYDPSKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGT-YTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQE-IGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLF--AAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVG----ENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE-GKIPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWK 595
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Match: Tec (tec protein tyrosine kinase [Source:MGI Symbol;Acc:MGI:98662]) HSP 1 Score: 359.377 bits (921), Expect = 2.273e-114 Identity = 227/610 (37.21%), Postives = 333/610 (54.59%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDD-LDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVES----------------RNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTK--QSGSLRVHHYRIRQQGVS-GPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
+ ++SQ KK S NYK R FVLT L Y++ + + K +++S IK +E V NDD + N F V D N LYI + + R+ W++ LK K + +YHP W G Y CC + + GCE +SS+ + E VVA+Y F + L+L +G+ Y +++ + WW RD YG W+ + +R +AE L E +EG F+VR SS GL T+S+ TK GS HY I++ S +YL+EKH + S+ E+IEYHKHNA GLV RLR V ++ ++ P + G D++E++ ++L + +G G FGVV+ G++R +VA+K + EG M EEDFI+EA+ M L HP LV+L+GV + +PI I+TE+M+ G + +FLR + +L C V +GM YL++ +F+HRDLAARNCLV VKV+DFGMAR++LD+ Y SS+G KFPV+W PEVF + +++++DVWSFG+LMWE+FT + P+ +N +V + G RL +P LY +ML CWQ
Sbjct: 11 LIKRSQQKKKTSPLNYKERLFVLTKSVLSYYEGRAEKKYR-KGVIDISKIKCVEIVKNDDGVIPCQNKFPFQVVHDAN-------TLYIFAPSPQSRDRWVKKLKEEIKNNNNIM-IKYHPKFWA-DGSYQCCRQTEKLAPGCEKYNLFESSIRKTLPPAPEIKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARDKYG--------------------WYCRNTNRSKAEQLLRTEDKEGGFMVRDSS--QPGLYTVSLYTKFGGEGSSGFRHYHIKETATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKNAPTTAGFSYDKWEINPSELTFMRE-LGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF--SRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG----VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEG-RMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQ 580
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q8JH64|BTK_CHICK (Tyrosine-protein kinase BTK OS=Gallus gallus OX=9031 GN=BTK PE=1 SV=1) HSP 1 Score: 382.874 bits (982), Expect = 5.428e-122 Identity = 227/634 (35.80%), Postives = 354/634 (55.84%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVLNDD-------LDNKSNVFQIGYVMDDNGGSYNLVV------LYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNN----------------------------TVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCN-HDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRN-RDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ ++ + K + + + Y V LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ S + S+++ + + E++ VVALY++ P+ LQL KGE Y +++ SH WW RD G GY+P ++V + ++W+ +++R QAE L +EG+EG FIVR S++ T+SV K + + + HY + +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ SR+ + P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FIDEA+ M L+H LV+L+GV K RPI IITEYM +G + +FLR + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++DVWSFG+LMWEV++ + PY +N++ ++++ G RL +P +R+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKKRLFLLTESKLSYYEYDFERGRRGSKKGSVDIEKITCVETVVPENNPPPERQVPKKGEDYNMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKSVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCKILESRNGSLKAGRSHRKTKKPLPPTPEEDTMVMKPLPPEPAPSAAGEMKKVVALYNYVPMNVQDLQLQKGEDYLILEESHLPWWKARDKNGREGYIPSNYVTATSNSLEIYEWYSKNITRSQAEQLLKQEGKEGGFIVRDSTSKTGKYTVSVYAKSAVDPQGMIRHYVVCCTP-QNQYYLAEKHLFNTIPELITYHQHNSAGLISRLKYPVSRHQKSAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNFLRETQRRF--QPAELLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----IVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLLYSKFSSKSDVWSFGVLMWEVYSLG-KMPYERFNNSETTEHVIQGLRLYRPQQASERVYAIMYSCWHE 634
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P35991|BTK_MOUSE (Tyrosine-protein kinase BTK OS=Mus musculus OX=10090 GN=Btk PE=1 SV=4) HSP 1 Score: 382.489 bits (981), Expect = 8.517e-122 Identity = 230/638 (36.05%), Postives = 360/638 (56.43%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVLNDDL-----------DNKSNVFQIGYVMDDNGGSYNLVV----LYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVE---SRNNTVK---------------------------WELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ + + S + QI +++ + +V LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ + + S++ S T K EL+ VVALY + P+ LQL KGE Y +++ S+ WW RD G+ GY+P +++ + ED ++W+ ++R QAE L +EG+EG FIVR SS T+SV K +G + + HY + S +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ V +N++ P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H LV+L+GV K RPI IITEYM +G + ++LR + + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE+++ + PY +N++ ++I G RL +P +R+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVIPEKNPPPERQIPRRGEESSEMEQIS-IIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTTELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGK-YTVSVFAKSTGEPQGVIRHYVVCSTPQSQ-YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG-KMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHE 636
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q06187|BTK_HUMAN (Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3) HSP 1 Score: 379.022 bits (972), Expect = 1.773e-120 Identity = 230/643 (35.77%), Postives = 360/643 (55.99%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYF--DISNNARGKLKDRLNLSSIKFIEKVL-----------------NDDLDNKSNVFQIGY---VMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVE---SRNNTVK---------------------------WELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
++SQ KK S N+K R F+LT L Y+ D RG K +++ I +E V+ + +++ S + + Y V+ D G LY+ S +E R+ WI LK + + Q +YHP WI G+Y CC + +MGC+++ + + S++ S T K EL+ VVALY + P+ LQL KG+ Y +++ S+ WW RD G+ GY+P ++V + ED ++W+ ++R QAE L +EG+EG FIVR SS T+SV K +G + + HY + S +YL+EKHL+ ++ ELI YH+HN+ GL+ RL+ V +N++ P + G+G +E+D DL K +G GQFGVVK G++R VA+K + EG M+E++FI+EA+ M L+H LV+L+GV K RPI IITEYM +G + ++LR + + + L + C V + M YL+ + F+HRDLAARNCLV VKV+DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE+++ + PY +N++ ++I G RL +P +++Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGP------LYVFSPTEELRKRWIHQLKNVIRYNSDLVQ-KYHPCFWID-GQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGK-YTVSVFAKSTGDPQGVIRHYVVCSTPQSQ-YYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKE-LGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG-KMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHE 636
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|P08630|BTKL_DROME (Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster OX=7227 GN=Btk29A PE=2 SV=2) HSP 1 Score: 379.793 bits (974), Expect = 2.449e-119 Identity = 202/427 (47.31%), Postives = 283/427 (66.28%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED--DFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGL-TLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY F I+ G L L K Y +ID S WW ++D G +GY+P ++V+ + ++W+ GD+SRQ+AES L + +EGCF+VR SST GL TLS+ TK S V HY I+Q +YLSEKH ++ +LI YH+HN+GGL RL+S P +R P + G+ D++E+ +L L + +G GQFGVV+RG++R ++ AVK M EG M+E+DFI+EA+ M L HPNLV+L+GV K RPI I+TEYMKHGS+ ++LR + G+L D C QV+KGM YL++ N++HRDLAARNCLV S + VKVADFG+AR++LD+ Y SS GTKFP++WA PEV +++++DVW++G+LMWE+F TC + PY N +V + + G L KP +C +Y +M CW H
Sbjct: 347 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSST--KGLYTLSLHTKVPQS-HVKHYHIKQNARC-EYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-DRPVPPTAGLSHDKWEIHPMELMLMEE-LGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIF-TCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSH 762 HSP 2 Score: 80.1073 bits (196), Expect = 3.484e-14 Identity = 50/176 (28.41%), Postives = 82/176 (46.59%), Query Frame = 3
Query: 129 LKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVL-----NDDLDNKSNVFQIGYV-MDDNGGSYNL-----------------------VVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGC 569
+KS M +++QNKK F+ NYK R F LT YFD+ N R + + R++L ++ +E+ D FQ+GY + + S+ L LY+++N ++ER +WI+ ++ + RYHPG+W K+SCC+ R + GC
Sbjct: 43 VKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLW-SGKKWSCCKGLSRTTFGC 217
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Match: sp|Q08881|ITK_HUMAN (Tyrosine-protein kinase ITK/TSK OS=Homo sapiens OX=9606 GN=ITK PE=1 SV=1) HSP 1 Score: 373.244 bits (957), Expect = 8.887e-119 Identity = 228/609 (37.44%), Postives = 348/609 (57.14%), Query Frame = 3
Query: 129 LKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSS-------VESRNNTVKWELES--VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR---VHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
L ++ +KSQ K+ S +N+K+R FVLT L YF+ + + LK + LS IK +E ++ D+ + V+ DN +LY+ + E R+ W+ LK + ++ P+YHP W+ GK+ CC + + GC ++ N WE E V+ALY + +L L + E Y L+D S WW ++D G GYVP S++ + ++ ++W+ +SR +AE L + G+EG F+VR S T T T+SV TK S + HY I++ + +Y++EK+++ S+ LI YH+HN GGLV RLR V + P++ G+ ++ +D ++L + IG GQFG+V G + N +VA+K + EG M+EEDFI+EA M L+HP LV+L+GV L+ PI ++ E+M+HG + D+LR + + L C V +GMAYL++ +HRDLAARNCLV + +KV+DFGM RF+LD+ Y SS GTKFPV+WA+PEVF + Y++++DVWSFG+LMWEVF+ + PY +SN++V + I G RL KP +Y +M CW+
Sbjct: 6 LLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE-IVKSDISIPCHYKYPFQVVHDN------YLLYVFAPDRESRQRWVLALKEETRNNNSLV-PKYHPNFWMD-GKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGT-YTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQE-IGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF--AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE----NQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEG-KIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWK 596
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A0X3Q0R1 (Tyrosine-protein kinase OS=Schistocephalus solidus OX=70667 GN=TR117312 PE=3 SV=1) HSP 1 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 277/476 (58.19%), Postives = 356/476 (74.79%), Query Frame = 3
Query: 636 SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRI-RQQGVS-----------------GP----------------------FYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQHVICYLFITIT 1934
+V+A++++ P++ QL L KGE+Y +++ S+ WWY+R+ G+ GYVP +++ + + + DW+Y D++RQQAE+ L EE REGCF+VR S + TLSV +K G L+VHHY I R +G S GP FYLSEKH +P+++++I YHKHN+GGLVVRLRS P ++R+ P++ G+GLDEFE+D +L++D+ IG+GQFGVVKRG+FRN+ VAVKQMVEG MNE+DFI+EA+NMRFLNHPNLV+LFGVVLK RPIMIITEYM++GS+RDFLR +++ N+ +L+D CAQV GMAYL++ FVHRDLAARNCLVKSV R S+ VKVADFGMARFLLDNVYE SAGTKFPVRWAAPEVFQ+IYT +ADVWSFG+LMWEVFT C++NPY+G +NAQVYQ+I+GGGRL KP CPDRLYVLMLECWQHV I ++
Sbjct: 377 TVIAVHNYNPVRENQLPLQKGEKYFVVNQSNAQWWYVRNMAGQAGYVPTNYIHKPNSLNSFDWYYKDITRQQAEAILLEESREGCFLVRDSVSKKNTFTLSVTSKDPEDPGKLKVHHYHIHRTEGSSLSLPNGHSNGFTNGIGGGPANGNSTSNSAGGGGGGAGGEAQFYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPVKDRESPVTAGMGLDEFELDPAELQIDRDPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNEDDFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMRYGSLRDFLRQRQSQFCNRPVMLADICAQVGNGMAYLEREQFVHRDLAARNCLVKSVSRNSIVVKVADFGMARFLLDNVYEPSAGTKFPVRWAAPEVFQSIYTDKADVWSFGVLMWEVFTYCLENPYHGMNNAQVYQFIVGGGRLHKPAICPDRLYVLMLECWQHVSLLFLIQLS 852 HSP 2 Score: 174.096 bits (440), Expect = 1.521e-41 Identity = 81/171 (47.37%), Postives = 119/171 (69.59%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVK 623
M +QELK SRM ++S NKK FSRA YKLREFVLT +KYFD+S RGK K R++LS++K++EKV +++LD NV Q+G+V D ++ L +Y++++ ER+DWI L++ Y+ + A F PRYHPGVW RPG+YSCC+D R S+GC+ + ++ ++V+
Sbjct: 1 MATDQELKISRMTKRSSNKKLFSRATYKLREFVLTPCFIKYFDVSGGNRGKEKGRISLSNVKYVEKVQDEELDGNKNVLQLGFVEDAAADAWFL--MYVIASSSMERDDWISLIRFYSGERGANFLPRYHPGVWRRPGRYSCCDDINRRSLGCQATTESIGVIQQLQSSVE 169
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A504YRP0 (Tyrosine-protein kinase OS=Fasciola gigantica OX=46835 GN=FGIG_02853 PE=3 SV=1) HSP 1 Score: 585.489 bits (1508), Expect = 0.000e+0 Identity = 274/465 (58.92%), Postives = 349/465 (75.05%), Query Frame = 3
Query: 636 SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRIRQQ---------------------------GVS---GP---------FYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+V+A++++ P++ QL L KGE+Y +++ S+ WWY+R+ G++GYVP ++V + + + DW+Y D++RQQAE+ L +E REGCF+VR S + TLSV +K G L+VHHY I + GVS GP +YLSEKH +P+++++I YHKHN+GGLVVRLRS P+++R+ P++ G+GLDEFE+D +L+L++ IG+GQFGVVKRG+FRN+ VAVKQMVEG MNE+DFI+EA+NMRFLNHPNLV+LFGVVLK RPIMIITEYMKHGS+RDF+R ++N+ +L+D CAQVA GMAYL+Q FVHRDLAARNCLVKSV R S+ VKVADFGMARFLLDNVYE SAGTKFPVRWA PEVFQ+ YT +ADVWSFG+LMWEVFT C +NPY G SN QVYQYI+GGGRL KP CP+R+YVLMLECWQH
Sbjct: 377 TVIAVHNYNPVRENQLPLQKGEKYYVVNQSNAQWWYVRNMAGQLGYVPTNYVHKPNSLNSFDWYYKDITRQQAEAILLDENREGCFLVRDSVSKKNTYTLSVTSKDPEAPGKLKVHHYHIHRTESASATNGHVNGTGLINGTSATSNGTGGVSRSVGPSTASSTEAQYYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPTKDRESPVTAGMGLDEFELDPAELQLEREPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNEDDFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMKHGSLRDFMRQRQPHFFNRPVVLADICAQVANGMAYLEQEQFVHRDLAARNCLVKSVSRNSVHVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQSTYTAKADVWSFGVLMWEVFTCCAENPYQGMSNTQVYQYIVGGGRLQKPAVCPERIYVLMLECWQH 841 HSP 2 Score: 179.489 bits (454), Expect = 3.097e-43 Identity = 87/154 (56.49%), Postives = 112/154 (72.73%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE 572
++ +QELK SRM ++SQNKK F R NY+LREFVL ++YF++S RGK K +L LS +KFIEKV +DD+D+K NVFQI Y D S+ L LYIV+N ER+DWI L++ Y + + AVF PRYHPGVW RPG+YSCC+D R SMGC+
Sbjct: 2 LSADQELKVSRMTKRSQNKKLFGRDNYRLREFVLHTYCIRYFEVSGGNRGKEKGQLLLSHVKFIEKVQDDDMDSKKNVFQIAYAEDALSTSWYL--LYIVANSAIERDDWISLVRFYTRERGAVFLPRYHPGVWKRPGRYSCCDDINRRSMGCQ 153
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A0X3NWK8 (Tyrosine-protein kinase OS=Schistocephalus solidus OX=70667 GN=TR117312 PE=3 SV=1) HSP 1 Score: 582.022 bits (1499), Expect = 0.000e+0 Identity = 275/466 (59.01%), Postives = 352/466 (75.54%), Query Frame = 3
Query: 636 SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRI-RQQGVS-----------------GP----------------------FYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+V+A++++ P++ QL L KGE+Y +++ S+ WWY+R+ G+ GYVP +++ + + + DW+Y D++RQQAE+ L EE REGCF+VR S + TLSV +K G L+VHHY I R +G S GP FYLSEKH +P+++++I YHKHN+GGLVVRLRS P ++R+ P++ G+GLDEFE+D +L++D+ IG+GQFGVVKRG+FRN+ VAVKQMVEG MNE+DFI+EA+NMRFLNHPNLV+LFGVVLK RPIMIITEYM++GS+RDFLR +++ N+ +L+D CAQV GMAYL++ FVHRDLAARNCLVKSV R S+ VKVADFGMARFLLDNVYE SAGTKFPVRWAAPEVFQ+IYT +ADVWSFG+LMWEVFT C++NPY+G +NAQVYQ+I+GGGRL KP CPDRLYVLMLECWQH
Sbjct: 377 TVIAVHNYNPVRENQLPLQKGEKYFVVNQSNAQWWYVRNMAGQAGYVPTNYIHKPNSLNSFDWYYKDITRQQAEAILLEESREGCFLVRDSVSKKNTFTLSVTSKDPEDPGKLKVHHYHIHRTEGSSLSLPNGHSNGFTNGIGGGPANGNSTSNSAGGGGGGAGGEAQFYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPVKDRESPVTAGMGLDEFELDPAELQIDRDPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNEDDFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMRYGSLRDFLRQRQSQFCNRPVMLADICAQVGNGMAYLEREQFVHRDLAARNCLVKSVSRNSIVVKVADFGMARFLLDNVYEPSAGTKFPVRWAAPEVFQSIYTDKADVWSFGVLMWEVFTYCLENPYHGMNNAQVYQFIVGGGRLHKPAICPDRLYVLMLECWQH 842 HSP 2 Score: 173.711 bits (439), Expect = 2.503e-41 Identity = 81/171 (47.37%), Postives = 119/171 (69.59%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVK 623
M +QELK SRM ++S NKK FSRA YKLREFVLT +KYFD+S RGK K R++LS++K++EKV +++LD NV Q+G+V D ++ L +Y++++ ER+DWI L++ Y+ + A F PRYHPGVW RPG+YSCC+D R S+GC+ + ++ ++V+
Sbjct: 1 MATDQELKISRMTKRSSNKKLFSRATYKLREFVLTPCFIKYFDVSGGNRGKEKGRISLSNVKYVEKVQDEELDGNKNVLQLGFVEDAAADAWFL--MYVIASSSMERDDWISLIRFYSGERGANFLPRYHPGVWRRPGRYSCCDDINRRSLGCQATTESIGVIQQLQSSVE 169
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A0X3PJC5 (Tyrosine-protein kinase OS=Schistocephalus solidus OX=70667 GN=TR117312 PE=3 SV=1) HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0 Identity = 275/466 (59.01%), Postives = 352/466 (75.54%), Query Frame = 3
Query: 636 SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRI-RQQGVS-----------------GP----------------------FYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
+V+A++++ P++ QL L KGE+Y +++ S+ WWY+R+ G+ GYVP +++ + + + DW+Y D++RQQAE+ L EE REGCF+VR S + TLSV +K G L+VHHY I R +G S GP FYLSEKH +P+++++I YHKHN+GGLVVRLRS P ++R+ P++ G+GLDEFE+D +L++D+ IG+GQFGVVKRG+FRN+ VAVKQMVEG MNE+DFI+EA+NMRFLNHPNLV+LFGVVLK RPIMIITEYM++GS+RDFLR +++ N+ +L+D CAQV GMAYL++ FVHRDLAARNCLVKSV R S+ VKVADFGMARFLLDNVYE SAGTKFPVRWAAPEVFQ+IYT +ADVWSFG+LMWEVFT C++NPY+G +NAQVYQ+I+GGGRL KP CPDRLYVLMLECWQH
Sbjct: 283 TVIAVHNYNPVRENQLPLQKGEKYFVVNQSNAQWWYVRNMAGQAGYVPTNYIHKPNSLNSFDWYYKDITRQQAEAILLEESREGCFLVRDSVSKKNTFTLSVTSKDPEDPGKLKVHHYHIHRTEGSSLSLPNGHSNGFTNGIGGGPANGNSTSNSAGGGGGGAGGEAQFYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSPPVKDRESPVTAGMGLDEFELDPAELQIDRDPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNEDDFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMRYGSLRDFLRQRQSQFCNRPVMLADICAQVGNGMAYLEREQFVHRDLAARNCLVKSVSRNSIVVKVADFGMARFLLDNVYEPSAGTKFPVRWAAPEVFQSIYTDKADVWSFGVLMWEVFTYCLENPYHGMNNAQVYQFIVGGGRLHKPAICPDRLYVLMLECWQH 748 HSP 2 Score: 79.337 bits (194), Expect = 1.833e-11 Identity = 31/75 (41.33%), Postives = 51/75 (68.00%), Query Frame = 3
Query: 399 LYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVK 623
+Y++++ ER+DWI L++ Y+ + A F PRYHPGVW RPG+YSCC+D R S+GC+ + ++ ++V+
Sbjct: 1 MYVIASSSMERDDWISLIRFYSGERGANFLPRYHPGVWRRPGRYSCCDDINRRSLGCQATTESIGVIQQLQSSVE 75
BLAST of Tyrosine-protein kinase vs. TrEMBL
Match: A0A5K3FDF5 (Tyrosine-protein kinase OS=Mesocestoides corti OX=53468 PE=4 SV=1) HSP 1 Score: 577.4 bits (1487), Expect = 0.000e+0 Identity = 276/475 (58.11%), Postives = 352/475 (74.11%), Query Frame = 3
Query: 624 WEL--ESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQ---SGSLRVHHYRIRQQ--------------GV-----------------------------SGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
WE ++V+A++++ P++ QL L KGE+Y +++ S+ WWY+R+ G+ GYVP +++ + + + DW+Y D++RQQAE+ L EE REGCF+VR S + TLSV +K SG LRVHHY I + GV FYLSEKH +P+++E+I YHKHN+GGLVVRLRS P ++R+ P++ G+GLDEFE+D +L++D+ IG+GQFGVVKRG+FRN+ VAVKQMVE MNEEDFI+EA+NMRFLNHPNLV+LFGVVLK RPIMIITEYMK+GS+RDFLR +++ N+ +L+D CAQV GMAYL++ FVHRDLAARNCLVKSV R S+ VKVADFGMARFLLDNVYE SAGTKFPVRWAAPEVFQ++YT +ADVWSFG+LMWEVFT CM+NPY+G +N+QVYQ+I+GGGRL KP CPDR+YVLMLECWQH
Sbjct: 292 WEENEKTVIAVHNYNPVRENQLPLQKGEKYYVVNDSNAQWWYVRNVAGQSGYVPTNYIHKPNSLNSFDWYYKDITRQQAEAILLEENREGCFLVRDSVSKKNTYTLSVTSKDPDVSGKLRVHHYHIHRNDGGTNLSNGHSNGAGVVSNGGNTNGNVSATQVNGGTTGSAGGGGGEAQFYLSEKHAFPTISEVIHYHKHNSGGLVVRLRSPPVKDRESPVTAGMGLDEFELDPAELQIDRDPIGKGQFGVVKRGKFRNIPVAVKQMVENAMNEEDFIEEAKNMRFLNHPNLVQLFGVVLKKRPIMIITEYMKYGSLRDFLRQRQSQFCNRPVVLADICAQVGNGMAYLEREQFVHRDLAARNCLVKSVSRNSVVVKVADFGMARFLLDNVYEPSAGTKFPVRWAAPEVFQSVYTDKADVWSFGVLMWEVFTYCMENPYHGMNNSQVYQFIVGGGRLHKPAICPDRIYVLMLECWQH 766 HSP 2 Score: 181.415 bits (459), Expect = 3.544e-44 Identity = 94/205 (45.85%), Postives = 129/205 (62.93%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCS 725
M +QELK SRM ++S NKK FSR +YKLREFVLT H+KYF++S RGK K R+ LS++K++EKVL+DDLD K NV Q+ YV D + S N +LYIV+ ER+DWI L++ Y + + A F PRYHPGVW RPG+YSCC+D R S GC+ + ++ E+ + T IQT + + G++ + S
Sbjct: 1 MATDQELKISRMTKRSVNKKIFSRPSYKLREFVLTPFHIKYFEVSGGNRGKEKGRVLLSNVKYVEKVLDDDLDGKKNVLQVAYVEDSS--STNWFLLYIVAPSLIERDDWISLIRFYTRERGACFLPRYHPGVWRRPGRYSCCDDINRRSHGCQHTFDSSTNTEAAEPHRLSSYPGCPPPVTSTEIQTPPVSPLGGQQSVAVMSS 203
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: tec (tec protein tyrosine kinase [Source:NCBI gene;Acc:103040058]) HSP 1 Score: 377.096 bits (967), Expect = 5.973e-121 Identity = 229/618 (37.06%), Postives = 353/618 (57.12%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNK-SNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELV-------------ISNDSSVESRN------------NTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV--QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQ-QGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
+ ++SQ KK S NYK R FVLT L Y++ + K K ++L +K +E V N + N + V D N LYI + +E R W+Q +K + ++ ++HP W + G + CC + + GCE I D S R + + E V+ALY F ++ L L +GE Y +I+ +W R+ YGE GY+P ++V ++ D+ W+ +V+R +AE QL EG+EG F+VR SS+ T+S+ TK G + HY I++ G FYL+EKHL+ S+ E+I+YHKHNA GLV RLR V ++N+ P + G +++E++ ++L K +G GQ+GVV+ G++R +VA+K + EG M+EEDFI+EA+ M L+HP LV+L+GV + RPI ++TE+M+ G + +++R + + +LS C +++GM YL++++++HRDLAARNCLV S VKV+DFGMAR++ D+ Y SS+G KFPV+W+ PEVF Y++++DVWSFG+LMWEVFT + P+ N +V + G RL +P ++Y +M CWQ
Sbjct: 11 LIKRSQQKKRTSPLNYKERVFVLTQSRLTYYEGRPEKKFK-KGSIDLQRVKCVEIVKNGGMVIPCQNKYPFQVVYDTN-------TLYIFAPSNESRSVWVQNMKEEIRNN-SLIVAKFHPQFW-QEGGWLCCGQAEKLAPGCEEYNLFGDISRKPLPPIPGDESKSRRPPPPPPPVPEPAAQEAELQEEVVIALYDFEGTESQDLTLHRGEEYVIIEKCDVNWHKARNKYGEEGYIPSNYVTLKQPDNLEQFVWYCKNVNRNKAEDQLRNEGKEGGFMVRDSSS-PGAYTVSLYTKSLGDGAIRHYHIKETSGSPKQFYLAEKHLFSSIPEVIDYHKHNAAGLVSRLRYPVNNQNKAAPTTAGFSYEKWEINPSELTFMKE-LGSGQYGVVRLGKWRAQHKVAIKAIREGAMSEEDFIEEAKVMMSLSHPKLVQLYGVCTQQRPIYLVTEFMELGCLLNYIRQRRGSF-SPQNLLS-ICHDISQGMQYLEEQHYIHRDLAARNCLVND----SHVVKVSDFGMARYVKDDQYVSSSGAKFPVKWSPPEVFNFCKYSSKSDVWSFGVLMWEVFTEG-KMPFEKNLNHEVVAMVTQGHRLYRPKMATPQIYDIMQLCWQ 609
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: BMX (BMX non-receptor tyrosine kinase [Source:NCBI gene;Acc:103025345]) HSP 1 Score: 356.295 bits (913), Expect = 8.992e-113 Identity = 231/667 (34.63%), Postives = 351/667 (52.62%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLK--IYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGC--------ELVISN-----DSSVESRN-----------NTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQR--------------------------------------EDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQHV 1907
M++E +K + + SQ KK S NYK R F+LT L Y++ R K + I +E V +D F DD +LY+ + D +R DWI +L I +L++ +YH G W+ GK+SCC + + GC + +IS+ SS+ S++ + V LE ++ALY ++ +L LVKG Y ++ S DWW +RD G G++P ++ + +D ++ W+ G++SR + E L E+G+ G F+VR SS + T+S+L + + + V HY I G +YL+E HL+ ++ +IEYH+HN+ G+ RLR + + D P S E+E+ D+ L K +G GQFGVV+ G ++ +VA+K + EG M+ +DFIDEA+ M L HP LVRL GV + PI I+TE+M +G + DFLR++ E + L + C V + MAYL+ + F+HRDLAARNCLV + L VKV+DFGMAR++LD+ Y SS GTKFPV+W+APEV +++++DVW+FG+LMWEV++ Q PY N QV + ++ G RL +P D++Y +M CW
Sbjct: 1 MSEEGVVKEGILLKMSQQKKKISPKNYKERLFILTNKTLSYYEHEKGKRKAKKGVVAAEKICCVEIVEPEDNAPAQREFPFQIAYDD-------CILYLFAKDDADRRDWIDVLMNVIKDNSKLSI---KYHKGFWMD-GKFSCCGQTVKNAPGCIQWHKDSADGLISSVRRFGASSLSSKHRESVHLPPIPESEVSSALE-IMALYDYSAQSPEELSLVKGSVYVCLEKSSDDWWKVRDTDGFEGFIPANYTKELEIKDYSIKTEIPRRSLKERPSGTKSHSAESLSSISPEKDSIEDYPWYVGNMSRAKTEQMLREKGKVGSFVVRDSSKRGS-YTVSLLNQATDEVTGTVSHYLINVNA-EGKYYLAENHLFDTIPRMIEYHQHNSAGMSTRLRRPATESDDTPPS---AHGEWELCREDVELVKE-LGSGQFGVVQLGMWKGQHEVAIKMVKEGCMSSDDFIDEAQIMMKLRHPKLVRLHGVCTERFPIYIVTEFMSNGCLLDFLRSHGKEM--QPPQLLNMCLDVCEAMAYLEDQQFIHRDLAARNCLVD----KDLTVKVSDFGMARYVLDDQYTSSPGTKFPVKWSAPEVLNYTKFSSKSDVWAFGVLMWEVYSLGKQ-PYEHYDNGQVAEKVMQGHRLYRPQLATDQIYQVMKACWHEA 642
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: BMX (BMX non-receptor tyrosine kinase [Source:NCBI gene;Acc:103025345]) HSP 1 Score: 356.295 bits (913), Expect = 8.992e-113 Identity = 231/667 (34.63%), Postives = 351/667 (52.62%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLK--IYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGC--------ELVISN-----DSSVESRN-----------NTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQR--------------------------------------EDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLR--VHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-QVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQHV 1907
M++E +K + + SQ KK S NYK R F+LT L Y++ R K + I +E V +D F DD +LY+ + D +R DWI +L I +L++ +YH G W+ GK+SCC + + GC + +IS+ SS+ S++ + V LE ++ALY ++ +L LVKG Y ++ S DWW +RD G G++P ++ + +D ++ W+ G++SR + E L E+G+ G F+VR SS + T+S+L + + + V HY I G +YL+E HL+ ++ +IEYH+HN+ G+ RLR + + D P S E+E+ D+ L K +G GQFGVV+ G ++ +VA+K + EG M+ +DFIDEA+ M L HP LVRL GV + PI I+TE+M +G + DFLR++ E + L + C V + MAYL+ + F+HRDLAARNCLV + L VKV+DFGMAR++LD+ Y SS GTKFPV+W+APEV +++++DVW+FG+LMWEV++ Q PY N QV + ++ G RL +P D++Y +M CW
Sbjct: 1 MSEEGVVKEGILLKMSQQKKKISPKNYKERLFILTNKTLSYYEHEKGKRKAKKGVVAAEKICCVEIVEPEDNAPAQREFPFQIAYDD-------CILYLFAKDDADRRDWIDVLMNVIKDNSKLSI---KYHKGFWMD-GKFSCCGQTVKNAPGCIQWHKDSADGLISSVRRFGASSLSSKHRESVHLPPIPESEVSSALE-IMALYDYSAQSPEELSLVKGSVYVCLEKSSDDWWKVRDTDGFEGFIPANYTKELEIKDYSIKTEIPRRSLKERPSGTKSHSAESLSSISPEKDSIEDYPWYVGNMSRAKTEQMLREKGKVGSFVVRDSSKRGS-YTVSLLNQATDEVTGTVSHYLINVNA-EGKYYLAENHLFDTIPRMIEYHQHNSAGMSTRLRRPATESDDTPPS---AHGEWELCREDVELVKE-LGSGQFGVVQLGMWKGQHEVAIKMVKEGCMSSDDFIDEAQIMMKLRHPKLVRLHGVCTERFPIYIVTEFMSNGCLLDFLRSHGKEM--QPPQLLNMCLDVCEAMAYLEDQQFIHRDLAARNCLVD----KDLTVKVSDFGMARYVLDDQYTSSPGTKFPVKWSAPEVLNYTKFSSKSDVWAFGVLMWEVYSLGKQ-PYEHYDNGQVAEKVMQGHRLYRPQLATDQIYQVMKACWHEA 642
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: tec (tec protein tyrosine kinase [Source:NCBI gene;Acc:103040058]) HSP 1 Score: 349.747 bits (896), Expect = 9.030e-111 Identity = 220/616 (35.71%), Postives = 342/616 (55.52%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNK-SNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELV-------------ISNDSSVESRN------------NTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQ-QGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
+ ++SQ KK S NYK R FVLT L Y++ + K K ++L +K +E V N + N + V D N LYI + +E R W+Q +K + ++ ++HP W + G + CC + + GCE I D S R + + E V+ALY F ++ L L +GE Y +I+ +W R+ YG GY+P ++V + +Q ++ L + G+EG F+VR SS+ T+S+ TK G + HY I++ G FYL+EKHL+ S+ E+I+YHKHNA GLV RLR V ++N+ P + G +++E++ ++L K +G GQ+GVV+ G++R +VA+K + EG M+EEDFI+EA+ M L+HP LV+L+GV + RPI ++TE+M+ G + +++R + ++ L C +++GM YL++++++HRDLAARNCLV S VKV+DFGMAR++ D+ Y SS+G KFPV+W+ PEVF Y++++DVWSFG+LMWEVFT + P+ N +V + G RL +P ++Y +M CWQ
Sbjct: 11 LIKRSQQKKRTSPLNYKERVFVLTQSRLTYYEGRPEKKFK-KGSIDLQRVKCVEIVKNGGMVIPCQNKYPFQVVYDTN-------TLYIFAPSNESRSVWVQNMKEEIRNN-SLIVAKFHPQFW-QEGGWLCCGQAEKLAPGCEEYNLFGDISRKPLPPIPGDESKSRRPPPPPPPVPEPAAQEAELQEEVVIALYDFEGTESQDLTLHRGEEYVIIEKCDVNWHKARNKYGYEGYIPSNYV----------------TLKQPDN-LEQFGKEGGFMVRDSSS-PGAYTVSLYTKSLGDGAIRHYHIKETSGSPKQFYLAEKHLFSSIPEVIDYHKHNAAGLVSRLRYPVNNQNKAAPTTAGFSYEKWEINPSELTFMKE-LGSGQYGVVRLGKWRAQHKVAIKAIREGAMSEEDFIEEAKVMMSLSHPKLVQLYGVCTQQRPIYLVTEFMELGCLLNYIRQRRGSFSPQN--LLSICHDISQGMQYLEEQHYIHRDLAARNCLVND----SHVVKVSDFGMARYVKDDQYVSSSGAKFPVKWSPPEVFNFCKYSSKSDVWSFGVLMWEVFTEG-KMPFEKNLNHEVVAMVTQGHRLYRPKMATPQIYDIMQLCWQ 590
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Match: btk (Bruton agammaglobulinemia tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070531-1]) HSP 1 Score: 341.273 bits (874), Expect = 9.224e-108 Identity = 214/621 (34.46%), Postives = 335/621 (53.95%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSV------ESRNNTVKWELE---------------------SVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQ----SGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPS-RNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSG--ILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
++SQ KK S N+K R FVLT + Y+D +EK V+ D G LY+ + D+ R+ W+ ++ + + Q +YHP W G + CC+ + +MGC ++ + + + +SR E +V+A Y + P+ L+L K E YT++ +W RD YG+ GY+P ++V + + +W+ +++R QAE+ L E ++G F+VR S T+SV TK SGS R ++ QQG FYL+EKH + ++ +LI YH+HNA GLV RL+ + S R + P + G+G +E+D L K +G GQFGVVK G+++ VA+K + EG M+E+DFI+EA+ M L H NLV+L+GV K RPI I+TE++ +G + +LR +Y +L + C V +GMAYL+ + ++HRDLAARNCLV S + VKV DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W+FG+LMWE++T + PY+ +N ++ + + GG RL +P DR+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNFKERLFVLTPDKISYYDFD------------------VEKA----------------VIYDEGP------LYVFARTDDVRKLWMNKIRHVIRFNKDLIQ-KYHPCFW-EDGAWKCCQQEVKQAMGCRVINTKNGGLFKSSRRQSRKPLPPTPEEEKPPRPLPPQPPPQPGFTVGMTVIAEYEYAPMAPQDLELRKDEEYTVLQICDANWLRARDKYGQEGYIPSNYVVEALNGLEKCEWYCKNMNRSQAENLLKTENKDGGFLVRDSGRLAGKYTVSVFTKSGGETSGSSRHYNILTTQQG---QFYLAEKHYFNNIPDLINYHQHNAAGLVSRLKYIVSNRAQHAPSTAGLGYGVWEIDPRQLTFIKE-LGNGQFGVVKYGKWQGRHDVAIKMIKEGSMSEDDFIEEAKVMMKLRHENLVQLYGVCTKQRPIYIVTEFLPNGCLLTYLR----DYLQHPSPLLLLEMCKDVTEGMAYLESQQYIHRDLAARNCLVDS----NGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYSKFSSKSDIWAFGVLMWEIYTLG-RMPYDRMNNTEIVEKVSGGHRLYRPQLANDRIYSVMTSCWH 577
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: btk (Bruton agammaglobulinemia tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-070531-1]) HSP 1 Score: 316.62 bits (810), Expect = 2.065e-99 Identity = 180/433 (41.57%), Postives = 269/433 (62.12%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRV-HHYRIRQQGVSGP---FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLD--EFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ--VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVF-QAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
V ALY+ T ++ L LV G+ Y ++D S WW RD G G++P ++V + ++W+ D+SR AE L EEG+EG F+VR SS T+S+ T G V HY+I++ V P +Y++E HL+ ++ LI YH+HN+ GLV RL+ SV SR R S G + ++E+D ++L L + +G GQFGVV+ G ++ ++ VA+K + E M+E+DFI+EA+ M L HP LV +GV + RP +++TEYM+ G++ F+R N + L CA V + MAYL++ +F+HRDLAARNCLV + VKV+DFGM+R++LD+ Y SS+GTKFPVRW+ PEVF +++++DVW+FGILMWEVF+ M PY+ SN+ V + + G RL +P ++++M CW
Sbjct: 122 VEALYNLTVTESQDLSLVAGQEYRVLDHSDEYWWKARDKQGREGFIPSNYVMEKTFKGLEAYEWYSKDISRSMAEQLLKEEGKEGGFVVRDSSHAGV-YTVSIYTNSLGDTGVVKHYQIKE--VCEPQRMYYVAENHLFENIPNLINYHQHNSAGLVARLKHSVLSRARTASFSSGQSSESRQWEIDPSELSLLQE-LGSGQFGVVRLGVWKRVRGNVAIKMLHEATMSEDDFIEEAKTMMRLWHPKLVHFYGVSCRKRPFLLVTEYMEAGNLESFVRERRGA--NSASQLLQMCADVCEAMAYLERESFLHRDLAARNCLVNAQG----TVKVSDFGMSRYVLDDQYTSSSGTKFPVRWSPPEVFLNNKFSSKSDVWAFGILMWEVFSEGML-PYDPWSNSNVVEQVQAGYRLYRPERATQPVHLIMHSCWH 543
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: txk (TXK tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-130530-553]) HSP 1 Score: 289.271 bits (739), Expect = 2.044e-91 Identity = 159/365 (43.56%), Postives = 235/365 (64.38%), Query Frame = 3
Query: 822 WFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMA--RFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
++ DV+R +AE L ++G++G ++VR SS T+SV T + + HY I++ G F+L+EKH++ S+ ELI YH+HNA LVVRLR V ++ P ++G ++E+D +L +G GQ+GVV+ G+++ + VAVK + EG M+EEDFI+EA+ M L+HP LV+L+GV + RP+ I+TEYM GS+ FL++ ++++ C V + M+YL+++ F+HRDLAARNCLV + VKV+DFGM R++LD+ Y S G KFPV+W+ PEVFQ ++T++DVWSFG+LMWEV+T P+ G SN QV IL G RL +P P Y +ML+CWQ
Sbjct: 1 YYSKDVTRVRAEQLLKQQGKDGSYMVRDSSQSGK-FTVSVFTTKPTE-TIKHYHIKETS-HGQFFLAEKHVFSSIPELIIYHQHNAAVLVVRLRHPVNHQSIGAPTTVGFSYQKWEIDPQELTFTHE-LGSGQYGVVRLGQWKRQKLVAVKMIQEGAMSEEDFIEEAKVMMQLSHPRLVQLYGVCTQQRPLCIVTEYMVGGSLLSFLKSQRGS--TVPELMAEICLDVCEAMSYLEEKMFLHRDLAARNCLVGEGNI----VKVSDFGMTSHRYVLDDQYTCSMGAKFPVKWSPPEVFQYTRFSTKSDVWSFGVLMWEVYTEG-HMPFEGWSNQQVVDEILRGCRLYQPALSPPTAYNIMLDCWQ 354
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 273.478 bits (698), Expect = 2.722e-84 Identity = 163/436 (37.39%), Postives = 246/436 (56.42%), Query Frame = 3
Query: 642 VALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMR--------DNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEE-GREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVG---LDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFL---LDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
VALY + L +GE + D ++ DWWY + + Y GY+P ++V WF+GD+ R AE L + G F++R S + T +LSV + GS V HYRIRQ +G F++S + + ++ EL++Y+K N+ GL + L+ P + P ++G+ +D++E+ ++L K +G G FG V +G + N VAVK + G M +E+FI EA+ M+ L H NL++L+ V + PI IITE M+HGS+ D+LR + K+ L D Q+A GMAYL+ +N++HRDLAARN LV KVADFG+AR + ++ YE AG K P++W APE ++ ++DVWSFGIL++E+ T + PY N +V + + G R+ +P NCP Y +MLECW
Sbjct: 2 VALYDYDGRTNEDLSFKEGELLEVTDKTNSDWWYAQKKTASTSNERYNTRGYIPANYVAEYQSLDAEPWFFGDIKRADAEKYLLADVNTTGAFLIRQSESRKTDYSLSV---RDGST-VKHYRIRQLDENGGFFISRRVTFQNLIELVQYYKSNSDGLCMALQK-PCVVIEAPTTIGLSYNTVDKWEIPRASIQLQKR-LGAGMFGEVWQGLWNNSTLVAVKTLKPGAMKKEEFIGEAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGKQL-KAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGE----GKVCKVADFGLARIIKVRYEDEYEGKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYG-RMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECW 425
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: clul1 (clusterin-like 1 (retinal) [Source:ZFIN;Acc:ZDB-GENE-031118-57]) HSP 1 Score: 259.996 bits (663), Expect = 5.022e-79 Identity = 156/433 (36.03%), Postives = 245/433 (56.58%), Query Frame = 3
Query: 642 VALYSFTPIQTGQLQLVKGERYTLIDCS--------HPDWWYMRD-NYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGR-EGCFIVRCSSTGDTGLTLSVLT-KQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
VALY + L KGE++ +I+ + DWW R + G GY+P ++V D +W++G VSR+ AE QL G G F++R S T +LS+ + V HY+IR+ +G +Y++ + + ++ +L++++ +A GL +L V + P + G+ D +E+ + L+L+ +GQG FG V G + +VA+K + G M+ E F++EA+ M+ L H LV+L+ VV PI I+TE+M GS+ DFL+ Y K L D AQ+A GMAY+++ N++HRDL A N LV +L K+ADFG+AR + DN Y + G KFP++W APE +T ++DVWSFGIL+ E+ T + PY G N +V + + G R+ PP+CP+ L+ LM++CW+
Sbjct: 19 VALYDYDARTQDDLSFRKGEKFQIINNTIEVAVVYREGDWWEARSLSTGNKGYIPSNYVAPADSVQAEEWYFGKVSRKDAERQLLCPGNPRGTFLIRESETTKGAYSLSIRDWDEVKGDNVKHYKIRKLD-NGGYYITTRAQFDTLQKLVQHYSEHADGLCYKLTLVCPNEK--PQTQGLARDAWEMPRDSLKLELK-LGQGCFGEVWAGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGRYL-KLPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGD----NLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAMFGRFTIKSDVWSFGILLTELVTKG-RVPYPGMVNREVLEQVERGYRMPCPPSCPESLHELMMQCWK 440
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Match: hck (HCK proto-oncogene, Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-090313-72]) HSP 1 Score: 251.521 bits (641), Expect = 2.083e-75 Identity = 155/429 (36.13%), Postives = 241/429 (56.18%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRD-NYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGRE-GCFIVRCSSTGDTGLTLSVLTK--QSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRL-RSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEF-RNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
VVALY + PI L +G++ +++ + DWW R + GY+P + V + + +WF+ +SR+ AE QL G + G +++R S T +LSV + G V HY+IR G ++++ + + ++ EL+ Y+ A GL +L + + P D +E+ ++L+K +G GQFG V G + + +VAVK M G M + F++EA M+ L H LVRL VV PI I+TEYM+ GS+ DFL+ + + ++ D CAQVA+GMA+++ +N++HRDL A N LV +L K+ADFG+AR + DN Y + G KFP++W APE ++ ++DVWSFGIL+ E+ T + PY G +N +V + + G R+ KP NCP LY +M ECW+
Sbjct: 68 VVALYDYDPIHADDLCFRRGDQLVIVEEGN-DWWKARSVATKKEGYIPSNFVAKVNSIEKEEWFFKGLSRKDAERQLLLCGNKIGSYLIRDSETNKGSYSLSVRDHIVEVGDT-VKHYKIRTLDKGG-YFITSRITFHTLQELVVYYHLKADGLCQKLGKPCIAIQPQKPWEK----DAWEIPRESIKLEKK-LGAGQFGDVWMGVYNKKTKVAVKMMKPGSMAPQAFLEEANLMKTLQHDKLVRLHAVVTD-EPIFIVTEYMEKGSLLDFLKTSEGSRLKQPKMI-DMCAQVAEGMAFIEDKNYIHRDLRAANILVNV----NLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFSIKSDVWSFGILLTEM-VTFGRIPYPGMTNPEVIRSLERGYRMPKPDNCPCELYSIMQECWRQ 481
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 88.9669 bits (219), Expect = 1.208e-18 Identity = 70/240 (29.17%), Postives = 122/240 (50.83%), Query Frame = 3
Query: 1194 KSAIGQGQFGVVKRG--EFRNMQVAVKQMV-EGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFL-RANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVF-QAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
K IG+G +GVV + + + VA+K++V E D + E ++ LNH N+V+ G + K+ + I+ EY +GS+R + R++ N+S Q G+ YL +HRD+ A N L+ S D VK+ADFG++ ++++ + AGT + W APE+ +T +D+WS G + E+ T PY+ ++A +Y Y + P + + L + +C+
Sbjct: 28 KQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTY---VTQTLLGLKYLHGEGVIHRDIKAANILL-SADN---TVKLADFGVST-IVNSSALTLAGT---LNWMAPEILGNRGASTLSDIWSLGATVVEMLTK--NPPYHNLTDANIY-YAVENDTYYPPSSFSEPLKDFLSKCF 253
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]) HSP 1 Score: 87.4261 bits (215), Expect = 3.971e-18 Identity = 76/258 (29.46%), Postives = 123/258 (47.67%), Query Frame = 3
Query: 1149 GLDEFEVDVNDLRLDKSAIGQGQFGVVKRG-EFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNH----PNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLR-ANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVY--ESSAGTKFPVRWAAPEVFQ--AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLE 1892
GL E E+DV+ L IG+G+FGVV +G + +V +++ + ++ D R ++FL N+ R +G LK + II E+ GS+R LR +E + G++ ++ + + + N +HRD+ A N L+ + VK+ DFG+A + ++ AGT + W APEV Y T+ D+WS GI +E+ T PY + Q I+ +KPP DR Y L+
Sbjct: 11 GLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKY--IGVI---MRELLVALKCIHKDNVIHRDIKAANVLITNEG----NVKLCDFGVAAQVNQTSLRRQTMAGTPY---WMAPEVIMEGVYYDTKVDIWSLGITTYEIATG--NPPYCDVEALRAMQLIIK----SKPPRLEDRSYSTSLK 250
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK2 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000006124]) HSP 1 Score: 85.1149 bits (209), Expect = 4.024e-18 Identity = 63/230 (27.39%), Postives = 104/230 (45.22%), Query Frame = 3
Query: 1200 AIGQGQFG------VVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQA-IYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPD 1868
+G G FG V G + ++V KQ V + E DE R ++ + HP L+R++G R I ++ +Y++ G + LR + + + A+V + YL N ++RDL N L+ R+ +K+ DFG A+ + V + GT + APEV Y D WS G+L++E+ P+ + + Y+ IL G + P PD
Sbjct: 75 TLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQR---FPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLD----RNGHIKITDFGFAK-EVQTVTWTLCGTP---DYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGY--TPFYDTTPMKTYEKILQGKVVYPPYFHPD 291
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 82.0333 bits (201), Expect = 4.695e-17 Identity = 58/226 (25.66%), Postives = 105/226 (46.46%), Query Frame = 3
Query: 1200 AIGQGQFGVVK------RGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQA-IYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPP 1856
+G G FG V G F ++ K + + E DE R + ++HP ++R++G ++ + ++ +Y++ G + LR + N + A+V + YL ++ ++RDL N L+ ++ +K+ DFG A+++ D Y + GT + APEV Y D WSFG+L++E+ P+ + + Y+ IL L PP
Sbjct: 93 TLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRK-SQRFPNP--VAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD----KNGHIKITDFGFAKYVPDVTY-TLCGTP---DYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGY--TPFYNSNTMKTYENIL-NAELKFPP 304
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 81.2629 bits (199), Expect = 8.836e-17 Identity = 62/226 (27.43%), Postives = 105/226 (46.46%), Query Frame = 3
Query: 1200 AIGQGQFGVVK------RGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAI-YTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPP 1856
+G G FG V G + M+V K++V + E DE + + HP ++R++G + I +I +Y++ G + LR + N + A+V + YL ++ ++RDL N L+ ++ +K+ DFG A+++ D Y + GT + APEV Y D WSFGIL++E+ P+ + + Y+ IL L PP
Sbjct: 92 TLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLR-KSQRFPNP--VAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD----KNGHIKITDFGFAKYVPDVTY-TLCGTP---DYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGY--TPFYDSNTMKTYEKIL-NAELRFPP 303
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO49804 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFY7]) HSP 1 Score: 204.912 bits (520), Expect = 2.080e-61 Identity = 104/218 (47.71%), Postives = 147/218 (67.43%), Query Frame = 3
Query: 1257 VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQHV 1907
VAVK M +G M+EEDFI+EA+ M+ H NLV+L+G+ +PI II E MK G + +LR + ++ +S +++ QVA M YL+ NF+HRDLAARNCL+ + R+ VKVADFG+AR+++D+ Y +S GTKFP++WAAPEV + +++++DVW+FGIL WEV+T Q PY +N V Q ++ G RL KP CPD Y M +CW V
Sbjct: 8 VAVKMMKDGAMSEEDFIEEAKVMKQFQHGNLVQLYGIC-SEKPIYIIQELMKGGCLLHYLRKS--QFKLQSAEMTEMVRQVAAAMKYLESHNFIHRDLAARNCLIG--ENRT--VKVADFGLARYVIDDEYTASEGTKFPIKWAAPEVILYSKFSSKSDVWAFGILAWEVYTGGKQ-PYPATNNTDVVQMVINGYRLEKPLRCPDAAYSTMRKCWHEV 217
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 196.823 bits (499), Expect = 2.010e-57 Identity = 103/251 (41.04%), Postives = 155/251 (61.75%), Query Frame = 3
Query: 1155 DEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR--NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVF-QAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
DE+E++ ++ + K +G GQ+G V G ++ N VAVK + E M E+F+ EA M+ + H NLV+L GV + P IITE+M +G++ D+LR+ + + ++ A QV M+YL+ NF+HRDLAARNCLV + VKVADFG++R + +++Y + G KFP++W APE ++ ++DVW+FGIL+WE+ T M +PY G +QVY + GG R+ P CP +Y LM CW
Sbjct: 5 DEWEIERTEIAM-KHKLGGGQYGEVYEGTWKKYNKTVAVKTLREETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMA-TQVGSAMSYLESMNFIHRDLAARNCLVGDNNL----VKVADFGLSRLVSEDIYTAHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGM-SPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCW 248
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 186.808 bits (473), Expect = 1.241e-53 Identity = 105/267 (39.33%), Postives = 158/267 (59.18%), Query Frame = 3
Query: 1155 DEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-------QVAVKQMVE--GVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSG-------ILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKF-PVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
DE+EV ++L + +G G FG+V GE ++ +VAVK + E + + +F+ EA M+ ++VRL GVV +P +++ E M +G +++FLR++ E +S + ++A GMAYL R FVHRDLAARNC+V + +L VK+ DFGM R + + Y G PVRW APE + ++T+ +DVWSFG++MWE+ T Q PY G+SN +V +Y++ GG + KP +CPDRL+ LM CWQ
Sbjct: 9 DEWEVPREKIKLIRE-LGNGSFGMVYEGEATDIVPNKPKCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPTLVVMELMDNGDLKNFLRSHRPEVTMESDEPPPTLQQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNA----NLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQ-PYPGKSNEEVLKYVVDGGVMPKPDDCPDRLFDLMTLCWQ 269
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO40994 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K8]) HSP 1 Score: 182.185 bits (461), Expect = 9.951e-51 Identity = 110/254 (43.31%), Postives = 153/254 (60.24%), Query Frame = 3
Query: 1164 EVDVNDLRLDKSAIGQGQFGVVKRGEFR-----NMQVAVKQMVEGVM--NEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGI-LSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
E+D L+L+K IG G+FG V +G + + VA+K + +G N DF+ EA M PN++ L GVV KT P+MI+TE+M +GS+ +FL+ ++ S I L +A GM YL + NFVHRDLAARN LV +L KVADFG++R L D+ YE+S G K PVRW APE + ++T +DVWS+GIL+WE F+ + PY SN +V + G RL P +CP ++ +MLECW
Sbjct: 52 ELDKRWLKLEK-VIGGGEFGDVYKGTLKRPGENTIPVAIKTLKQGSTSKNRGDFLSEASVMGQFCDPNVIFLEGVVSKTHPLMIVTEFMSNGSLDNFLKKMDSKL---SLIQLMGMARGIASGMKYLSEMNFVHRDLAARNILVT----ETLVCKVADFGLSRELEDSAYETSGG-KIPVRWTAPEAIKYRKFSTSSDVWSYGILLWETFSFA-ERPYWDWSNFEVMDRVETGYRLPPPMSCPKVIHQIMLECW 295
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 177.178 bits (448), Expect = 3.904e-49 Identity = 107/258 (41.47%), Postives = 151/258 (58.53%), Query Frame = 3
Query: 1164 EVDVNDLRLDKSAIGQGQFGVVKRGEFRNM-----QVAVKQMVEGV--MNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSA-----GTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
E++ +DL+L+ IG G+F V RG N +VAVK + G N EDF EA M +HPN++ L GV+ +TRP+MIITE++++GS+ +FL++N L VA GMAYL + NF+HRDLAARN LV +L KV+DFG++R L D+ + G K PVRW APE + +++ +DVWS+GIL+WE+ + + PY N QV + GG RL P CP ++ LML+CW
Sbjct: 21 EINKDDLKLE-IIIGGGEFADVYRGVLTNEDKTQEKVAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQ--LVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSD----NLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFG-ERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCW 270
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: tec (tyrosine-protein kinase Tec [Source:NCBI gene;Acc:101170709]) HSP 1 Score: 370.548 bits (950), Expect = 1.499e-118 Identity = 240/622 (38.59%), Postives = 346/622 (55.63%), Query Frame = 3
Query: 141 RMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNK-SNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE-------------------------LVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
R+ ++SQ KK S NYK R FVLT L Y+D + K K + LS I+ +E V N N + V D N LY+ + R W+Q LK K V ++HP W+ G + CC + ++GCE + IS+D E + E E VVALY F + L+L+KG+ Y +++ S +W+ R++YGE GY+P ++V + + + W+ V+R +AE L E + G F+VR SST T T+SV TK G + HY I++ S P FYL+EKHL+ S+ ELIEYHKHNA GLV RLR V ++ P + G + +E++ ++L K +G GQFG V+ G++R +VA+K + EG M+EEDFI+EA+ M L+HP LV+L+GV + +PI I+TE+M+HGS+ FL+ + G L V +GM YL+ F+HRDLA+RNCLV SL VKV+DFGM RF+LD+ Y SS+G +FPV+W+ PEVF Y++++DVWS+G+LMWEVFT + P++ N +V ++ G RL KP LY +M CW+
Sbjct: 10 RLIKRSQQKKITSPLNYKERLFVLTKNKLTYYDGKPEKKFK-KGSIELSRIRCVEIVKNGGGTIPCQNKYPFQIVYDTN-------TLYVFAPSQSSRSIWVQSLKDEIKDNQVVLV-KFHPLFWLD-GAWLCCRQVEKQALGCEEYNLFGDITRKPLPPLPVKRQPPPPVPISDDGEDEDVDEDDDDEEEVVVALYDFPATEPHDLRLIKGDEYIIVERSDANWFKARNHYGEEGYIPSNYVTEKISGNLVQYGWYSKQVNRNKAEELLRNEDKAGAFMVRDSSTPGT-YTVSVYTKAPAGDGGGAIKHYHIKKTEASPPQFYLAEKHLFYSIPELIEYHKHNAAGLVTRLRYPVGKPDKSAPSTAGFSYEMWEINPSELTFMKE-LGCGQFGQVRLGKWRAQHKVAIKFIREGAMSEEDFIEEAKIMMKLSHPKLVQLYGVCSQQKPIYIVTEFMEHGSLLHFLQRGRGGF--SLGSLLSISLDVCEGMEYLEAHGFIHRDLASRNCLVND----SLAVKVSDFGMTRFVLDDQYTSSSGARFPVKWSPPEVFNFCKYSSKSDVWSYGVLMWEVFTEG-RMPFDNNLNHEVVTLVMQGHRLYKPKLATPTLYEIMHLCWK 612
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: tec (tyrosine-protein kinase Tec [Source:NCBI gene;Acc:101170709]) HSP 1 Score: 370.548 bits (950), Expect = 1.499e-118 Identity = 240/622 (38.59%), Postives = 346/622 (55.63%), Query Frame = 3
Query: 141 RMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNK-SNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE-------------------------LVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
R+ ++SQ KK S NYK R FVLT L Y+D + K K + LS I+ +E V N N + V D N LY+ + R W+Q LK K V ++HP W+ G + CC + ++GCE + IS+D E + E E VVALY F + L+L+KG+ Y +++ S +W+ R++YGE GY+P ++V + + + W+ V+R +AE L E + G F+VR SST T T+SV TK G + HY I++ S P FYL+EKHL+ S+ ELIEYHKHNA GLV RLR V ++ P + G + +E++ ++L K +G GQFG V+ G++R +VA+K + EG M+EEDFI+EA+ M L+HP LV+L+GV + +PI I+TE+M+HGS+ FL+ + G L V +GM YL+ F+HRDLA+RNCLV SL VKV+DFGM RF+LD+ Y SS+G +FPV+W+ PEVF Y++++DVWS+G+LMWEVFT + P++ N +V ++ G RL KP LY +M CW+
Sbjct: 10 RLIKRSQQKKITSPLNYKERLFVLTKNKLTYYDGKPEKKFK-KGSIELSRIRCVEIVKNGGGTIPCQNKYPFQIVYDTN-------TLYVFAPSQSSRSIWVQSLKDEIKDNQVVLV-KFHPLFWLD-GAWLCCRQVEKQALGCEEYNLFGDITRKPLPPLPVKRQPPPPVPISDDGEDEDVDEDDDDEEEVVVALYDFPATEPHDLRLIKGDEYIIVERSDANWFKARNHYGEEGYIPSNYVTEKISGNLVQYGWYSKQVNRNKAEELLRNEDKAGAFMVRDSSTPGT-YTVSVYTKAPAGDGGGAIKHYHIKKTEASPPQFYLAEKHLFYSIPELIEYHKHNAAGLVTRLRYPVGKPDKSAPSTAGFSYEMWEINPSELTFMKE-LGCGQFGQVRLGKWRAQHKVAIKFIREGAMSEEDFIEEAKIMMKLSHPKLVQLYGVCSQQKPIYIVTEFMEHGSLLHFLQRGRGGF--SLGSLLSISLDVCEGMEYLEAHGFIHRDLASRNCLVND----SLAVKVSDFGMTRFVLDDQYTSSSGARFPVKWSPPEVFNFCKYSSKSDVWSYGVLMWEVFTEG-RMPFDNNLNHEVVTLVMQGHRLYKPKLATPTLYEIMHLCWK 612
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: btk (Bruton tyrosine kinase [Source:NCBI gene;Acc:101168549]) HSP 1 Score: 369.392 bits (947), Expect = 3.773e-118 Identity = 223/618 (36.08%), Postives = 343/618 (55.50%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYFD--ISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNN------TVKWELES-------------------VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS----GSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
++SQ KK S NYK R FVLT L Y+D R L+ +++ IK +E V + + F V D+ LYI + + R +WI LK + + Q +YHP W G + CC+ + +MGC+++ N + +R+ T E S V+A Y +TP+ L+L E YT+++ S P+WW RD YG+ GY+P ++V + E W+ +++R QAE L E ++G F+VR SS T+S+ K GS R HY I G FYLSEKH + ++ ELI YH+HNA G+V RL+ + S P + G+G +E+D + L K +G GQFGVVK G+++ VA+K + EG M+E+DFI+EA+ M L H NLV+L+GV K RPI I+TE++ +G + +L+ ++ +L + C V++GMAYL+ + ++HRDLAARNCLV + + VKV DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W++G+LMWEV+T + PY +N+++ + G RL +P +R+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNYKERLFVLTAEKLAYYDYDADKGKRKGLRGSVDVEKIKCVETVETEPNAPQERRFAFQVVYDEGP-------LYIFAKSENSRTEWITKLKELVRYNKDLMQ-KYHPCFWAD-GVWLCCQQEVKQAMGCKILDKNGYASRTRSTRKPLPPTPSEEKPSPSRRLPPQPESAAPSSSMTVIAEYDYTPMTAQDLELRTNEEYTILEKSDPNWWRARDKYGKEGYIPSNYVAEAESGLERFHWYCKNMNRSQAEQLLKSENKDGGFLVRDSSKAGK-YTVSLFAKSGAETGGSCR--HYNICTTP-QGQFYLSEKHNFDTIPELINYHQHNAAGMVCRLKHIVSNRARPPSTAGLGYGVWEIDPHYLTFIKE-LGTGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLYGVCTKQRPIYIVTEFLANGCLLTYLKEGLIQHPTADQLL-EMCKDVSEGMAYLESQQYIHRDLAARNCLVDA----NGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYSKFSSKSDIWAYGVLMWEVYTLG-RLPYERLNNSEIVDQVSHGFRLYRPQLANERVYKIMTSCWH 609
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: btk (Bruton tyrosine kinase [Source:NCBI gene;Acc:101168549]) HSP 1 Score: 369.392 bits (947), Expect = 3.773e-118 Identity = 223/618 (36.08%), Postives = 343/618 (55.50%), Query Frame = 3
Query: 150 QKSQNKKFFSRANYKLREFVLTGMHLKYFD--ISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNN------TVKWELES-------------------VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHV-QREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS----GSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEV-FQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
++SQ KK S NYK R FVLT L Y+D R L+ +++ IK +E V + + F V D+ LYI + + R +WI LK + + Q +YHP W G + CC+ + +MGC+++ N + +R+ T E S V+A Y +TP+ L+L E YT+++ S P+WW RD YG+ GY+P ++V + E W+ +++R QAE L E ++G F+VR SS T+S+ K GS R HY I G FYLSEKH + ++ ELI YH+HNA G+V RL+ + S P + G+G +E+D + L K +G GQFGVVK G+++ VA+K + EG M+E+DFI+EA+ M L H NLV+L+GV K RPI I+TE++ +G + +L+ ++ +L + C V++GMAYL+ + ++HRDLAARNCLV + + VKV DFG++R++LD+ Y SS G+KFPVRW+ PEV + +++++D+W++G+LMWEV+T + PY +N+++ + G RL +P +R+Y +M CW
Sbjct: 12 KRSQQKKKTSPLNYKERLFVLTAEKLAYYDYDADKGKRKGLRGSVDVEKIKCVETVETEPNAPQERRFAFQVVYDEGP-------LYIFAKSENSRTEWITKLKELVRYNKDLMQ-KYHPCFWAD-GVWLCCQQEVKQAMGCKILDKNGYASRTRSTRKPLPPTPSEEKPSPSRRLPPQPESAAPSSSMTVIAEYDYTPMTAQDLELRTNEEYTILEKSDPNWWRARDKYGKEGYIPSNYVAEAESGLERFHWYCKNMNRSQAEQLLKSENKDGGFLVRDSSKAGK-YTVSLFAKSGAETGGSCR--HYNICTTP-QGQFYLSEKHNFDTIPELINYHQHNAAGMVCRLKHIVSNRARPPSTAGLGYGVWEIDPHYLTFIKE-LGTGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLYGVCTKQRPIYIVTEFLANGCLLTYLKEGLIQHPTADQLL-EMCKDVSEGMAYLESQQYIHRDLAARNCLVDA----NGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYSKFSSKSDIWAYGVLMWEVYTLG-RLPYERLNNSEIVDQVSHGFRLYRPQLANERVYKIMTSCWH 609
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Match: tec (tyrosine-protein kinase Tec [Source:NCBI gene;Acc:101170709]) HSP 1 Score: 369.777 bits (948), Expect = 1.197e-117 Identity = 240/628 (38.22%), Postives = 348/628 (55.41%), Query Frame = 3
Query: 123 QELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNK-SNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCE-------------------------LVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRE--DDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQS---GSLRVHHYRIRQQGVSGP-FYLSEKHLWPSVTELIEYHKHNAGGLVVRLR-SVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFR-NMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQ-AIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQ 1901
+ + R+ ++SQ KK S NYK R FVLT L Y+D + K K + LS I+ +E V N N + V D N LY+ + R W+Q LK K V ++HP W+ G + CC + ++GCE + IS+D E + E E VVALY F + L+L+KG+ Y +++ S +W+ R++YGE GY+P ++V + + + W+ V+R +AE L E + G F+VR SST T T+SV TK G + HY I++ S P FYL+EKHL+ S+ ELIEYHKHNA GLV RLR V ++ P + G + +E++ ++L K +G GQFG V+ G++R +VA+K + EG M+EEDFI+EA+ M L+HP LV+L+GV + +PI I+TE+M+HGS+ FL+ + G L V +GM YL+ F+HRDLA+RNCLV SL VKV+DFGM RF+LD+ Y SS+G +FPV+W+ PEVF Y++++DVWS+G+LMWEVFT + P++ N +V ++ G RL KP LY +M CW+
Sbjct: 46 EPILEERLIKRSQQKKITSPLNYKERLFVLTKNKLTYYDGKPEKKFK-KGSIELSRIRCVEIVKNGGGTIPCQNKYPFQIVYDTN-------TLYVFAPSQSSRSIWVQSLKDEIKDNQVVLV-KFHPLFWLD-GAWLCCRQVEKQALGCEEYNLFGDITRKPLPPLPVKRQPPPPVPISDDGEDEDVDEDDDDEEEVVVALYDFPATEPHDLRLIKGDEYIIVERSDANWFKARNHYGEEGYIPSNYVTEKISGNLVQYGWYSKQVNRNKAEELLRNEDKAGAFMVRDSSTPGT-YTVSVYTKAPAGDGGGAIKHYHIKKTEASPPQFYLAEKHLFYSIPELIEYHKHNAAGLVTRLRYPVGKPDKSAPSTAGFSYEMWEINPSELTFMKE-LGCGQFGQVRLGKWRAQHKVAIKFIREGAMSEEDFIEEAKIMMKLSHPKLVQLYGVCSQQKPIYIVTEFMEHGSLLHFLQRGRGGF--SLGSLLSISLDVCEGMEYLEAHGFIHRDLASRNCLVND----SLAVKVSDFGMTRFVLDDQYTSSSGARFPVKWSPPEVFNFCKYSSKSDVWSYGVLMWEVFTEG-RMPFDNNLNHEVVTLVMQGHRLYKPKLATPTLYEIMHLCWK 654
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000032667.1 (SMESG000032667.1) HSP 1 Score: 1251.11 bits (3236), Expect = 0.000e+0 Identity = 596/598 (99.67%), Postives = 597/598 (99.83%), Query Frame = 3
Query: 111 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED+FCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEG MNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH
Sbjct: 1 MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDNFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGAMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 598 HSP 2 Score: 57.3806 bits (137), Expect = 3.257e-8 Identity = 25/25 (100.00%), Postives = 25/25 (100.00%), Query Frame = 2
Query: 1961 EPTKRPGFQYISSKITDFLDQNCDN 2035
EPTKRPGFQYISSKITDFLDQNCDN
Sbjct: 599 EPTKRPGFQYISSKITDFLDQNCDN 623
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000032667.1 (SMESG000032667.1) HSP 1 Score: 1226.46 bits (3172), Expect = 0.000e+0 Identity = 585/587 (99.66%), Postives = 586/587 (99.83%), Query Frame = 3
Query: 144 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQRED+FCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEG MNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH
Sbjct: 1 MYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGKLKDRLNLSSIKFIEKVLNDDLDNKSNVFQIGYVMDDNGGSYNLVVLYIVSNCDEEREDWIQLLKIYAKIQLAVFQPRYHPGVWIRPGKYSCCEDGYRWSMGCELVISNDSSVESRNNTVKWELESVVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDNYGEMGYVPRSHVQREDNFCNHDWFYGDVSRQQAESQLYEEGREGCFIVRCSSTGDTGLTLSVLTKQSGSLRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGLDEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQVAVKQMVEGAMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 587 HSP 2 Score: 57.3806 bits (137), Expect = 3.142e-8 Identity = 25/25 (100.00%), Postives = 25/25 (100.00%), Query Frame = 2
Query: 1961 EPTKRPGFQYISSKITDFLDQNCDN 2035
EPTKRPGFQYISSKITDFLDQNCDN
Sbjct: 588 EPTKRPGFQYISSKITDFLDQNCDN 612
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000027869.1 (SMESG000027869.1) HSP 1 Score: 339.347 bits (869), Expect = 2.201e-112 Identity = 155/194 (79.90%), Postives = 176/194 (90.72%), Query Frame = 3
Query: 1323 MRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLDNVYESSAGTKFPVRWAAPEVFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECWQH 1904
MRFLNHPNLV+LFGVV+K RPIMIITEYMKHGS+RDFLR ++Y+N+ +L+D CAQVAKGMAYL+ NFVHRDLAARNCLVK+V RRS+QVKVADFGMARFLLDNVYE SAGTKFPVRWA PEVFQ+IYT +ADVWSFG+LMWEVFT C +NPY+G++N+QVYQYI+GGGRL KP CPDRLYVLMLECWQH
Sbjct: 1 MRFLNHPNLVQLFGVVMKKRPIMIITEYMKHGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLELENFVHRDLAARNCLVKTVSRRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQSIYTPKADVWSFGVLMWEVFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQH 194
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000020289.1 (SMESG000020289.1) HSP 1 Score: 273.478 bits (698), Expect = 4.868e-83 Identity = 161/429 (37.53%), Postives = 246/429 (57.34%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDN-YGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGR-EGCFIVRCSSTGDTGLTLSVLTKQSGS-LRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGL-DEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLD---NVYESSAGTKFPVRWAAPE-VFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
++A++ + ++ L KG+R L++ + PDWW + G GYVP S + E F + DW++ ++R+ AE L + G GCF++R S T LSVL S V+HY+I++ G Y++ K ++PS+T+LI Y+ + GL L S+ L D++E+D + L+L + +G GQFG V RG + VAVK + G M +EDF+ EA+ M+ L H NLVRL+ + PI I+TE M GS+ +LR+ + ++ D +Q+A GMAYL+ +VHRDLAARN LV + K+ADFG+AR L+D +YE+S G++FPV+W APE ++T++DVWSFG+L++E+ T Q P+ SN++ Q I G R+ P CP +Y +ML+CW
Sbjct: 67 LIAIFDYKARTIDEIYLKKGDRVILLESNDPDWWLVEQRATGNRGYVPSSFLAVEYSFESQDWYFPFITRKDAERSLLQPGNARGCFLIRASETTQGAQCLSVLDHPVNSGYVVNHYKIKKTN-QGAVYITTKKIFPSLTQLILYYSNAPNGLCCSLSHPCSKPTPIISDLSYKTKDKWEIDRSSLQLSEK-LGAGQFGEVWRGLWNGTTPVAVKTLKPGTMTKEDFLKEAKVMKSLCHINLVRLYAIC-SDEPIYIVTELMSKGSLLQYLRSETGQAMILKQLI-DFISQIANGMAYLENSGYVHRDLAARNILVGEGE----ICKIADFGLAR-LIDAGCEMYEASQGSRFPVKWTAPEAALWGKFSTKSDVWSFGVLIYEIITR-GQVPFPSMSNSEALQNIETGYRMPSPKQCPSYIYEIMLQCW 485
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Match: SMESG000020289.1 (SMESG000020289.1) HSP 1 Score: 273.863 bits (699), Expect = 2.305e-82 Identity = 161/429 (37.53%), Postives = 246/429 (57.34%), Query Frame = 3
Query: 639 VVALYSFTPIQTGQLQLVKGERYTLIDCSHPDWWYMRDN-YGEMGYVPRSHVQREDDFCNHDWFYGDVSRQQAESQLYEEGR-EGCFIVRCSSTGDTGLTLSVLTKQSGS-LRVHHYRIRQQGVSGPFYLSEKHLWPSVTELIEYHKHNAGGLVVRLRSVPSRNRDCPISLGVGL-DEFEVDVNDLRLDKSAIGQGQFGVVKRGEFRNMQ-VAVKQMVEGVMNEEDFIDEARNMRFLNHPNLVRLFGVVLKTRPIMIITEYMKHGSMRDFLRANCNEYWNKSGILSDACAQVAKGMAYLDQRNFVHRDLAARNCLVKSVDRRSLQVKVADFGMARFLLD---NVYESSAGTKFPVRWAAPE-VFQAIYTTRADVWSFGILMWEVFTTCMQNPYNGQSNAQVYQYILGGGRLAKPPNCPDRLYVLMLECW 1898
++A++ + ++ L KG+R L++ + PDWW + G GYVP S + E F + DW++ ++R+ AE L + G GCF++R S T LSVL S V+HY+I++ G Y++ K ++PS+T+LI Y+ + GL L S+ L D++E+D + L+L + +G GQFG V RG + VAVK + G M +EDF+ EA+ M+ L H NLVRL+ + PI I+TE M GS+ +LR+ + ++ D +Q+A GMAYL+ +VHRDLAARN LV + K+ADFG+AR L+D +YE+S G++FPV+W APE ++T++DVWSFG+L++E+ T Q P+ SN++ Q I G R+ P CP +Y +ML+CW
Sbjct: 135 LIAIFDYKARTIDEIYLKKGDRVILLESNDPDWWLVEQRATGNRGYVPSSFLAVEYSFESQDWYFPFITRKDAERSLLQPGNARGCFLIRASETTQGAQCLSVLDHPVNSGYVVNHYKIKKTN-QGAVYITTKKIFPSLTQLILYYSNAPNGLCCSLSHPCSKPTPIISDLSYKTKDKWEIDRSSLQLSEK-LGAGQFGEVWRGLWNGTTPVAVKTLKPGTMTKEDFLKEAKVMKSLCHINLVRLYAIC-SDEPIYIVTELMSKGSLLQYLRSETGQAMILKQLI-DFISQIANGMAYLENSGYVHRDLAARNILVGEGE----ICKIADFGLAR-LIDAGCEMYEASQGSRFPVKWTAPEAALWGKFSTKSDVWSFGVLIYEIITRG-QVPFPSMSNSEALQNIETGYRMPSPKQCPSYIYEIMLQCW 553 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30021052 ID=SMED30021052|Name=Tyrosine-protein kinase|organism=Schmidtea mediterranea sexual|type=transcript|length=2207bpback to top protein sequence of SMED30021052-orf-1 >SMED30021052-orf-1 ID=SMED30021052-orf-1|Name=SMED30021052-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=656bp MNDEQELKSSRMYQKSQNKKFFSRANYKLREFVLTGMHLKYFDISNNARGback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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