Guanine nucleotide exchange factor

Overview
NameGuanine nucleotide exchange factor
Smed IDSMED30021016
Length (bp)4186
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Guanine nucleotide exchange factor (SMED30021016) t-SNE clustered cells

Violin plots show distribution of expression levels for Guanine nucleotide exchange factor (SMED30021016) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Guanine nucleotide exchange factor (SMED30021016) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Guanine nucleotide exchange factor (SMED30021016) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30021016

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30021016h1SMcG0006440 dd_Smed_v4_12864_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30021016h1SMcG0006440 dd_Smed_v4_12864_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymaSMED30021016h1SMcG0006440 dd_Smed_v4_12864_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807])

HSP 1 Score: 179.104 bits (453), Expect = 2.661e-46
Identity = 119/318 (37.42%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L++L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E          I+ P + H +FSNV+ ++  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  159 LWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERI------RKILHPSEAHILFSNVLDVLAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-ECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 459
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807])

HSP 1 Score: 179.489 bits (454), Expect = 6.192e-46
Identity = 119/318 (37.42%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L++L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E          I+ P + H +FSNV+ ++  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  251 LWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERI------RKILHPSEAHILFSNVLDVLAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-ECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 551
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF16 (Rho guanine nucleotide exchange factor 16 [Source:HGNC Symbol;Acc:HGNC:15515])

HSP 1 Score: 172.17 bits (435), Expect = 1.658e-43
Identity = 120/326 (36.81%), Postives = 178/326 (54.60%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTIE 2633
            +Y   Q  WS +PEV E GIL  LS  E + QEAMFEI+TSE SY  SL IL + F        S++    V+ ++ HH+FSN++ ++  S     DLEQR H+ + ++ DI DI+  H     F  Y+ Y  N+ YQ + L++L S N  F++ L ++E    CG L + S+L+LPMQR+TRL LL++ +         T   SE  K  A  AL  I  L+   N     M++   + +L  ++ F   VKS+    + R LL+  EL +   TG+   RKI+ +  P   L LFND+L++TKKKS    +V DY+   ++ +E
Sbjct:  255 SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQ------SKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQR-HKAQVLVEDISDILEEHA-EKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCL------KTQGHSERYK-AASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDF-SKVKSLPLISASRWLLKRGELFLVEETGL--FRKIASR--PTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVE 560
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF19 (Rho guanine nucleotide exchange factor 19 [Source:HGNC Symbol;Acc:HGNC:26604])

HSP 1 Score: 160.229 bits (404), Expect = 2.499e-39
Identity = 121/374 (32.35%), Postives = 182/374 (48.66%), Query Frame = 3 
Query: 1551 NQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQR-----MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQS-YVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKS-GRLLVLDYSNKANVTIETSSFK 2648
             Q  +E  P     G++     P+ N      +  +SS    R+ R     +W D+P+V  SG+L  LS  + +LQEA FE+ITSEASY  SL +   HF  S   S        +   DK  +FS +  +  TS   L DLEQR  E   +   +CD+VL+H  +  F+  Y+ Y+ NQ YQ +  +R L EN  F   L++LE S  C +L L S+L+LP QR+TRLK+LVE + K +  +G  +E      + A  A + +K L+   N     M +   LI L  +I+F   +  +    R L+R  EL V             K     + L LFND L+++++K  G+  V  ++  A + +   S K
Sbjct:  309 RQQREEEGPGDEAEGAEEGPGPPRAN------LSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELS------ECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRL-EADVLRFSVCDVVLDHCPA--FRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILK-RTAQGSEDE------DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGEL-VELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLK 659
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Match: ARHGEF16 (Rho guanine nucleotide exchange factor 16 [Source:HGNC Symbol;Acc:HGNC:15515])

HSP 1 Score: 142.895 bits (359), Expect = 1.193e-35
Identity = 103/292 (35.27%), Postives = 158/292 (54.11%), Query Frame = 3 
Query: 1770 MFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTIE 2633
            MFEI+TSE SY  SL IL + F  S+      +    V+ ++ HH+FSN++ ++  S     DLEQR H+ + ++ DI DI+  H     F  Y+ Y  N+ YQ + L++L S N  F++ L ++E    CG L + S+L+LPMQR+TRL LL++ +         T   SE  K  A  AL  I  L+   N     M++   + +L  ++ F   VKS+    + R LL+  EL +   TG+   RKI+ +  P   L LFND+L++TKKKS    +V DY+   ++ +E
Sbjct:    1 MFEILTSEFSYQHSLSILVEEFLQSK------ELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQR-HKAQVLVEDISDILEEHA-EKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCL------KTQGHSERYK-AASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDF-SKVKSLPLISASRWLLKRGELFLVEETGL--FRKIASR--PTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVE 272
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 157.918 bits (398), Expect = 1.554e-39
Identity = 115/336 (34.23%), Postives = 184/336 (54.76%), Query Frame = 3 
Query: 1644 RVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQL-QEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINR-IYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKK-SGRLLVLDYSNKANVTIE 2633
            R R   + N+   + +W ++PEV  +G+L+ L  +E +L QEA FE+ITSEASY RSL +L  HF +S     S+   +++S  D+ H+FSN+  +   S  LL DLE R  EE  ++ DICDI+ +H     F+ Y+ Y  NQ YQ + L+RL +EN  F   + +LE + +C  L + S+LMLPMQR+TR  LL+ A+     ++ IT   ++     A  AL     ++   N     M++   L+ +  R IY   ++K I    + R L+++  L          I +  +K + L V  LF+D+++ITKKK +G  +  DY+ +  V ++
Sbjct:  133 RDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLD-DECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRL-EENLILDDICDILSDH-FDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAI-----LDRITT--TDDRYKTATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLVERRSSNILQSRQKARTLHVF-LFSDMIMITKKKLNGTFVCKDYAARRFVDMQ 457
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 158.303 bits (399), Expect = 1.753e-39
Identity = 115/336 (34.23%), Postives = 184/336 (54.76%), Query Frame = 3 
Query: 1644 RVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQL-QEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINR-IYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKK-SGRLLVLDYSNKANVTIE 2633
            R R   + N+   + +W ++PEV  +G+L+ L  +E +L QEA FE+ITSEASY RSL +L  HF +S     S+   +++S  D+ H+FSN+  +   S  LL DLE R  EE  ++ DICDI+ +H     F+ Y+ Y  NQ YQ + L+RL +EN  F   + +LE + +C  L + S+LMLPMQR+TR  LL+ A+     ++ IT   ++     A  AL     ++   N     M++   L+ +  R IY   ++K I    + R L+++  L          I +  +K + L V  LF+D+++ITKKK +G  +  DY+ +  V ++
Sbjct:  177 RDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLD-DECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRL-EENLILDDICDILSDH-FDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAI-----LDRITT--TDDRYKTATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLVERRSSNILQSRQKARTLHVF-LFSDMIMITKKKLNGTFVCKDYAARRFVDMQ 501
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 158.303 bits (399), Expect = 9.147e-39
Identity = 115/340 (33.82%), Postives = 186/340 (54.71%), Query Frame = 3 
Query: 1644 RVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQL-QEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINR-IYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKI----SKKKQPLIVLVLFNDLLIITKKK-SGRLLVLDYSNKANVTIE 2633
            R R   + N+   + +W ++PEV  +G+L+ L  +E +L QEA FE+ITSEASY RSL +L  HF +S     S+   +++S  D+ H+FSN+  +   S  LL DLE R  EE  ++ DICDI+ +H     F+ Y+ Y  NQ YQ + L+RL +EN  F   + +LE + +C  L + S+LMLPMQR+TR  LL+ A+     ++ IT   ++     A  AL     ++   N     M++   L+ +  R IY   ++K I    + R L+++  L     T +   R      S++K   + + LF+D+++ITKKK +G  +  DY+ +  V ++
Sbjct:  504 RDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLD-DECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRL-EENLILDDICDILSDH-FDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAI-----LDRITT--TDDRYKTATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVL-----TQLVERRSSNILQSRQKARTLHVFLFSDMIMITKKKLNGTFVCKDYAARRFVDMQ 828
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Match: ephx-1 (EPHeXin (Eph-interacting GEF) homolog [Source:UniProtKB/TrEMBL;Acc:A0A1D3PD25])

HSP 1 Score: 158.303 bits (399), Expect = 1.023e-38
Identity = 115/340 (33.82%), Postives = 186/340 (54.71%), Query Frame = 3 
Query: 1644 RVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQL-QEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINR-IYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKI----SKKKQPLIVLVLFNDLLIITKKK-SGRLLVLDYSNKANVTIE 2633
            R R   + N+   + +W ++PEV  +G+L+ L  +E +L QEA FE+ITSEASY RSL +L  HF +S     S+   +++S  D+ H+FSN+  +   S  LL DLE R  EE  ++ DICDI+ +H     F+ Y+ Y  NQ YQ + L+RL +EN  F   + +LE + +C  L + S+LMLPMQR+TR  LL+ A+     ++ IT   ++     A  AL     ++   N     M++   L+ +  R IY   ++K I    + R L+++  L     T +   R      S++K   + + LF+D+++ITKKK +G  +  DY+ +  V ++
Sbjct:  644 RDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLD-DECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRL-EENLILDDICDILSDH-FDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAI-----LDRITT--TDDRYKTATDALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVL-----TQLVERRSSNILQSRQKARTLHVFLFSDMIMITKKKLNGTFVCKDYAARRFVDMQ 968
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Match: rhgf-1 (RHo Guanine nucleotide exchange Factor [Source:UniProtKB/TrEMBL;Acc:G5EFE1])

HSP 1 Score: 55.8398 bits (133), Expect = 2.582e-7
Identity = 84/347 (24.21%), Postives = 154/347 (44.38%), Query Frame = 3 
Query: 1635 ESIRVRKTSSLNYSRNQRMWSDMPEVNES---------GILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNV---ILIMKTSLNLLNDLEQRWHEEKP-----VMSDICDIVLNHVISDD-----FQSYVTYLRNQQYQTQALK---RLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVL 2600
            + I VR+T++L +SR     SD     E+          +++ L   E + QE + E+  +E ++ R+L IL   F+   + S       IV+    + +F+N+   + + K+  + +    ++W    P     +  DI  +++  +   +      +   T+ ++QQ+  + L+   +  +++ F + L++ ES+  C KL L   + + MQRL +  LL+E ++K+      T E SE  +N     +   K +L+  NT K   +    L  L  R    P  K     D   L   + R+  + G  T R    K   L V++L N L++ TK   G  LVL
Sbjct:  693 DDICVRRTTTLQFSRFMDGDSDFEIETEATPLEQLIGWDVIRHLKPKEKKRQEVINELFHTERTHVRNLKILYHVFYKPIVTS------KIVTEELANLLFANLEELLNLHKSMSDAMRAEVEKWRSAPPRVNGGIYGDI-GVLMESMFDGEAAENLMRVTATFCQHQQHALEFLRTRCKREKDDAFVRFLAEAESNPVCRKLQLKDMIPVEMQRLVKYPLLLETIAKY------TTEPSEE-QNCLLRTVASAKRILSAVNTAKRNAENLRRLEELQKRTDTSPFDKEFVGHDYTNLNLTKFRL-VHDGPLTCRFNRGKMIELHVVLLENMLVLFTKNSDGNKLVL 1024
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302647)

HSP 1 Score: 147.902 bits (372), Expect = 1.807e-35
Identity = 106/338 (31.36%), Postives = 170/338 (50.30%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENE---YFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFS----------DRILLREEELRVHPYTG-------IKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL-VLDYSNKANVTIETS 2639
            +WS++PEV  S IL  L+  E  LQEA FEIITSEASY +SL +L +HF +   F  S    +++S  D+  +FS ++ + + S  LL +LE  W +   +M       +  +    F  YV +  +Q    + L+RL E++    F+Q L +LE+S  C  L+L S+LMLPMQR+TRL LL++AV  F     +  E  ES K    + L  ++ ++   N      +Q   L  +  ++ FP +V+++  +           R L++  EL    + G        K + KIS      I   LF+DLL++ K++      V DY  ++ +T+   
Sbjct:  575 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN--IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWK----LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKIS------IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAG 894
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302648)

HSP 1 Score: 147.902 bits (372), Expect = 1.807e-35
Identity = 106/338 (31.36%), Postives = 170/338 (50.30%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENE---YFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFS----------DRILLREEELRVHPYTG-------IKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL-VLDYSNKANVTIETS 2639
            +WS++PEV  S IL  L+  E  LQEA FEIITSEASY +SL +L +HF +   F  S    +++S  D+  +FS ++ + + S  LL +LE  W +   +M       +  +    F  YV +  +Q    + L+RL E++    F+Q L +LE+S  C  L+L S+LMLPMQR+TRL LL++AV  F     +  E  ES K    + L  ++ ++   N      +Q   L  +  ++ FP +V+++  +           R L++  EL    + G        K + KIS      I   LF+DLL++ K++      V DY  ++ +T+   
Sbjct:  575 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN--IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWK----LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKIS------IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAG 894
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302649)

HSP 1 Score: 147.902 bits (372), Expect = 1.807e-35
Identity = 106/338 (31.36%), Postives = 170/338 (50.30%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENE---YFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFS----------DRILLREEELRVHPYTG-------IKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL-VLDYSNKANVTIETS 2639
            +WS++PEV  S IL  L+  E  LQEA FEIITSEASY +SL +L +HF +   F  S    +++S  D+  +FS ++ + + S  LL +LE  W +   +M       +  +    F  YV +  +Q    + L+RL E++    F+Q L +LE+S  C  L+L S+LMLPMQR+TRL LL++AV  F     +  E  ES K    + L  ++ ++   N      +Q   L  +  ++ FP +V+++  +           R L++  EL    + G        K + KIS      I   LF+DLL++ K++      V DY  ++ +T+   
Sbjct:  575 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN--IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWK----LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKIS------IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAG 894
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302651)

HSP 1 Score: 147.517 bits (371), Expect = 4.360e-35
Identity = 106/335 (31.64%), Postives = 170/335 (50.75%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENE---YFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFS----------DRILLREEELRVHPYTG-------IKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL-VLDYSNKANVTI 2630
            +WS++PEV  S IL  L+  E  LQEA FEIITSEASY +SL +L +HF +   F  S    +++S  D+  +FS ++ + + S  LL +LE  W +   +M       +  +    F  YV +  +Q    + L+RL E++    F+Q L +LE+S  C  L+L S+LMLPMQR+TRL LL++AV  F     +  E  ES K    + L  ++ ++   N      +Q   L  +  ++ FP +V+++  +           R L++  EL    + G        K + KIS      I   LF+DLL++ K++      V DY  ++ +T+
Sbjct: 1553 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN--IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWK----LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKIS------IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTL 1869
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Match: Exn (gene:FBgn0261547 transcript:FBtr0302650)

HSP 1 Score: 147.517 bits (371), Expect = 4.360e-35
Identity = 106/335 (31.64%), Postives = 170/335 (50.75%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENE---YFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFS----------DRILLREEELRVHPYTG-------IKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL-VLDYSNKANVTI 2630
            +WS++PEV  S IL  L+  E  LQEA FEIITSEASY +SL +L +HF +   F  S    +++S  D+  +FS ++ + + S  LL +LE  W +   +M       +  +    F  YV +  +Q    + L+RL E++    F+Q L +LE+S  C  L+L S+LMLPMQR+TRL LL++AV  F     +  E  ES K    + L  ++ ++   N      +Q   L  +  ++ FP +V+++  +           R L++  EL    + G        K + KIS      I   LF+DLL++ K++      V DY  ++ +T+
Sbjct: 1553 LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRKALFSYIVPVHECSERLLTELEACWQDN--IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWK----LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKIS------IYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTL 1869
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292])

HSP 1 Score: 167.933 bits (424), Expect = 1.799e-43
Identity = 126/378 (33.33%), Postives = 199/378 (52.65%), Query Frame = 3 
Query: 1575 PIYGKRGSKNSEND-------PQVNHR---ESIRVRKTSSLNYSRNQR--------MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSE-NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPP-NVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSG---RLLVLDYSNKANVTIETS 2639
            P+Y    +K S+ D       P  N R   E++ +    SL     Q         +W D+P V ESG+L  L++ E Q QE+MFE++TSEASY RSL +L  HF  S      E  ET+V   D+  +FSN++ + + S   + DL +R  +E  V+SD+ DI+  H   + F  Y+ Y+RNQQYQ +   +L E N  F   + +LE S  C +L   S+++LP QR+TR+K+L++++ K +  +G   E        A  AL  +  L+  +N + G M Q   LI+  N++ F    V  I    R L +  EL+     G  ++  +  +  P + + LFNDLLI+T +KSG   R  V+DY++++ V ++ +
Sbjct:   12 PLYQIYQAKLSKEDSQIQTVSPDCNRRSVSETLGLEGHGSLGVVGTQSKRGPEEITLWQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSR-----ELNETLVIH-DRKVLFSNLLQVYEVSERFIRDLLKRV-DESVVISDVSDIIYEHS-ENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLCKRLPFTSFMLLPFQRITRIKILIQSIQK-RTAKGTKEE------ETASKALTSVSKLITQANQQVGQMKQMEELINTSNKLEFDKVKVIPIVSKTRCLEKHGELQELSKRG--SLFSMRNRCSP-VYMFLFNDLLILTTRKSGCPDRFTVIDYAHRSLVQVQAT 371
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef15 (Rho guanine nucleotide exchange factor (GEF) 15 [Source:ZFIN;Acc:ZDB-GENE-060526-292])

HSP 1 Score: 167.933 bits (424), Expect = 9.468e-42
Identity = 111/321 (34.58%), Postives = 180/321 (56.07%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSE-NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSG---RLLVLDYSNKANVTIETS 2639
            +W D+P V ESG+L  L++ E Q QE+MFE++TSEASY RSL +L  HF  S      E  ET+V   D+  +FSN++ + + S   + DL +R  +E  V+SD+ DI+  H   + F  Y+ Y+RNQQYQ +   +L E N  F   + +LE S  C +L   S+++LP QR+TR+K+L++++ K +  +G   E        A  AL  +  L+  +N + G M Q   LI+  N++ F   VK I    +    E+   +   +   ++  +  +  P + + LFNDLLI+T +KSG   R  V+DY++++ V ++ +
Sbjct:  469 LWQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLRSLRVLKDHFLGSR-----ELNETLVI-HDRKVLFSNLLQVYEVSERFIRDLLKRV-DESVVISDVSDIIYEHS-ENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVVMRRLELSPLCKRLPFTSFMLLPFQRITRIKILIQSIQK-RTAKGTKEE------ETASKALTSVSKLITQANQQVGQMKQMEELINTSNKLEF-DKVKVIPIVSKTRCLEKHGELQELSKRGSLFSMRNRCSP-VYMFLFNDLLILTTRKSGCPDRFTVIDYAHRSLVQVQAT 772
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:ZFIN;Acc:ZDB-GENE-081104-446])

HSP 1 Score: 160.614 bits (405), Expect = 1.957e-40
Identity = 114/319 (35.74%), Postives = 171/319 (53.61%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYT-GIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYS 2609
            NY      WS +P+V + GIL  ++  E + QE +FEIITSE SY  SL IL +H      F  S D    ++  + HH+FSN+ +I   S     DL++R H+  PV+  I DIV  +  +  F+ Y+ Y  N+ +Q + L++ LS N  F++ L ++E+S +CG L + S+L+LPMQR+TRL LL++ +      E  T E +E  K  A  A   I  L+ + N     M++   + ++  ++ F   +K      S R L +  EL V  YT  +   RK    K     L LFND+LI+TKKKS    +VLDY+
Sbjct:  204 NYRAAYITWSQLPQVKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRH------FKDSVDLRKTMTATEHHHLFSNISVIQDVSKRFFEDLDKR-HQANPVIERISDIVATYA-TKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLKQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTI-----CEKTTKETAEYYK--ACWAFKAISKLVKSCNDGARRMERTEQMYTIQKQMEF-GKIKPFPLVSSSRWLKKSGELAV--YTDDLSIFRKAFSFKS--YYLFLFNDVLIVTKKKSEESYVVLDYA 502
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:ZFIN;Acc:ZDB-GENE-081104-446])

HSP 1 Score: 160.229 bits (404), Expect = 2.328e-40
Identity = 114/319 (35.74%), Postives = 171/319 (53.61%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYT-GIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYS 2609
            NY      WS +P+V + GIL  ++  E + QE +FEIITSE SY  SL IL +H      F  S D    ++  + HH+FSN+ +I   S     DL++R H+  PV+  I DIV  +  +  F+ Y+ Y  N+ +Q + L++ LS N  F++ L ++E+S +CG L + S+L+LPMQR+TRL LL++ +      E  T E +E  K  A  A   I  L+ + N     M++   + ++  ++ F   +K      S R L +  EL V  YT  +   RK    K     L LFND+LI+TKKKS    +VLDY+
Sbjct:  204 NYRAAYITWSQLPQVKDLGILDFITPEERKRQEVIFEIITSEYSYQHSLSILVRH------FKDSVDLRKTMTATEHHHLFSNISVIQDVSKRFFEDLDKR-HQANPVIERISDIVATYA-TKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLKQIETSEDCGGLPMLSFLILPMQRVTRLPLLMDTI-----CEKTTKETAEYYK--ACWAFKAISKLVKSCNDGARRMERTEQMYTIQKQMEF-GKIKPFPLVSSSRWLKKSGELAV--YTDDLSIFRKAFSFKS--YYLFLFNDVLIVTKKKSEESYVVLDYA 502
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Match: ngef (neuronal guanine nucleotide exchange factor [Source:ZFIN;Acc:ZDB-GENE-130530-794])

HSP 1 Score: 154.451 bits (389), Expect = 1.504e-38
Identity = 119/330 (36.06%), Postives = 179/330 (54.24%), Query Frame = 3 
Query: 1656 TSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            T+SLN      +W ++  V +SG+L+ L   EI LQEAMFE++TSEASYY+SL +L  HF  + L          +S  D H +FSN+  IMK S   L DLE R  EE  ++SD+CDIV  H + + FQ +++Y+ NQ YQ    +R L EN  F++ ++ LE+  +   LS  S+L+LP QR+TRLKLLV      QNI     E SE  +  A +A  +++ ++   N     M +   LIS+   + F      +    R LL++ E  V   +G K+ R +  +K   P+ + +  N LLI  +  SG +  VLD  +++ +  E
Sbjct:  103 TNSLN------LWQNLDAVKKSGLLQTLEPKEIILQEAMFELVTSEASYYKSLELLETHFLRNPLLV------NTLSQSDMHFLFSNITDIMKASEKFLMDLEHRI-EESILISDVCDIVHFHAV-NHFQVFISYVINQVYQETNYRRILQENCAFRENMAILENQPKVKGLSFTSFLILPFQRITRLKLLV------QNILKRVEENSEK-ERTAILAHQELEKIVKQCNEGARKMSRTEELISIEKTLEFKSKSVPVISHSRWLLKKGE--VQQMSGPKSTRTMRSRKLYHPIYLFLFNNLLLITKRNSSGDKFQVLDSCSRSMLRTE 409
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663])

HSP 1 Score: 182.185 bits (461), Expect = 1.943e-47
Identity = 122/320 (38.12%), Postives = 181/320 (56.56%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAV-SKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+P+V +SG+L +L   E++LQEAMFE++TSEASYY+SL ++  HF  SE    S  +  I      H IFSNV+ ++ TS   L  LEQR+ EE  V+SD+CDIV  H     F  YVTY+ NQ YQ +A ++ L E   F++ +  LE+   C  L   S+L+LP QR+TRLKLLV+ + +K +  EG   E+S      A  A  +++ L+   N     M +   LIS+   + F      I    R L+++ EL+    +G +T R +  KK  +P + L LFNDLL++ K  +G R  V D + +  + +E
Sbjct:  143 LWQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVVSHFMDSERLRASLHQSEI------HFIFSNVLEVLATSERFLLALEQRF-EENIVISDVCDIVYEHA-EKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVE--EGSEREVS------ALQAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQ--MSGPRTSRTLRTKKLFRP-VYLFLFNDLLLMCKPLTGERYQVFDVAARGLLRVE 443
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663])

HSP 1 Score: 180.644 bits (457), Expect = 3.858e-47
Identity = 123/319 (38.56%), Postives = 179/319 (56.11%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+P+V +SG+L +L   E++LQEAMFE++TSEASYY+SL ++  HF  SE    S  +  I      H IFSNV+ ++ TS   L  LEQR+ EE  V+SD+CDIV  H     F  YVTY+ NQ YQ +A ++ L E   F++ +  LE+   C  L   S+L+LP QR+TRLKLLV      QNI     E SE  + +A  A  +++ L+   N     M +   LIS+   + F      I    R L+++ EL+    +G +T R +  KK  +P + L LFNDLL++ K  +G R  V D + +  + +E
Sbjct:  107 LWQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVVSHFMDSERLRASLHQSEI------HFIFSNVLEVLATSERFLLALEQRF-EENIVISDVCDIVYEHA-EKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLV------QNILTKVEEGSER-EVSALQAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQ--QMSGPRTSRTLRTKKLFRP-VYLFLFNDLLLMCKPLTGERYQVFDVAARGLLRVE 407
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: NGEF (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:100487663])

HSP 1 Score: 182.57 bits (462), Expect = 4.699e-47
Identity = 122/320 (38.12%), Postives = 181/320 (56.56%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAV-SKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+P+V +SG+L +L   E++LQEAMFE++TSEASYY+SL ++  HF  SE    S  +  I      H IFSNV+ ++ TS   L  LEQR+ EE  V+SD+CDIV  H     F  YVTY+ NQ YQ +A ++ L E   F++ +  LE+   C  L   S+L+LP QR+TRLKLLV+ + +K +  EG   E+S      A  A  +++ L+   N     M +   LIS+   + F      I    R L+++ EL+    +G +T R +  KK  +P + L LFNDLL++ K  +G R  V D + +  + +E
Sbjct:  234 LWQDLPDVRKSGVLALLQPEEVKLQEAMFELLTSEASYYKSLRLVVSHFMDSERLRASLHQSEI------HFIFSNVLEVLATSERFLLALEQRF-EENIVISDVCDIVYEHA-EKHFVVYVTYVCNQTYQERAYRKLLQERPEFRESVGHLETDPVCRGLPFSSFLILPFQRITRLKLLVQNILTKVE--EGSEREVS------ALQAHRELEKLVRACNDGVRKMSRTEQLISIEKTLEFKIKSVPIISHSRWLMKQGELQQ--MSGPRTSRTLRTKKLFRP-VYLFLFNDLLLMCKPLTGERYQVFDVAARGLLRVE 534
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: arhgef16 (Rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:549614])

HSP 1 Score: 181.415 bits (459), Expect = 1.234e-46
Identity = 124/319 (38.87%), Postives = 177/319 (55.49%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGI--KTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDY 2606
            NY   Q +WS +PEV ESGIL  +S  E + QEA+FEIITSE SY  SL IL +      LF  SE+ +  ++  + HH+FSN+  I + S     DLE+R H+E P + +I DIV +H   + FQ YV+Y  N+ YQ + L+RL S N  FK  L ++E  +ECG L + S+L+LPMQR+TRL LL++ +   Q ++  T E  E+       AL  +  L+   N     M++   + +L  ++ F   +K      + R LL+  EL +   +G+  K   K S        L LFND+LIITKKKS    +V DY
Sbjct:  239 NYRPAQLIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVR------LFKKSEELKQTITNTEHHHLFSNIAEIQEVSKRFFEDLEKR-HKENPFIDNISDIVEHHA-QNKFQPYVSYCSNEMYQQRTLQRLMSTNGTFKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTIC--QKMDMRTKEYGETTH-----ALKALSKLVKQCNEGARKMERTEQMYTLQTQLEF-GKIKPFPLISASRWLLKRGELNLVEESGVFWKGFGKTS------CYLFLFNDILIITKKKSEENYIVTDY 535
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Match: arhgef16 (Rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:549614])

HSP 1 Score: 181.415 bits (459), Expect = 1.524e-46
Identity = 124/319 (38.87%), Postives = 177/319 (55.49%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGI--KTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDY 2606
            NY   Q +WS +PEV ESGIL  +S  E + QEA+FEIITSE SY  SL IL +      LF  SE+ +  ++  + HH+FSN+  I + S     DLE+R H+E P + +I DIV +H   + FQ YV+Y  N+ YQ + L+RL S N  FK  L ++E  +ECG L + S+L+LPMQR+TRL LL++ +   Q ++  T E  E+       AL  +  L+   N     M++   + +L  ++ F   +K      + R LL+  EL +   +G+  K   K S        L LFND+LIITKKKS    +V DY
Sbjct:  254 NYRPAQLIWSQLPEVQESGILNKISPEERKRQEAIFEIITSEYSYQHSLGILVR------LFKKSEELKQTITNTEHHHLFSNIAEIQEVSKRFFEDLEKR-HKENPFIDNISDIVEHHA-QNKFQPYVSYCSNEMYQQRTLQRLMSTNGTFKDTLKQIEMKAECGGLPMFSFLILPMQRVTRLPLLMDTIC--QKMDMRTKEYGETTH-----ALKALSKLVKQCNEGARKMERTEQMYTLQTQLEF-GKIKPFPLISASRWLLKRGELNLVEESGVFWKGFGKTS------CYLFLFNDILIITKKKSEENYIVTDY 550
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414])

HSP 1 Score: 181.8 bits (460), Expect = 2.458e-47
Identity = 120/318 (37.74%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L +L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E        + I+ P + H +FSNV+ +M  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  161 LWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERL------KKILHPSEAHILFSNVLDVMAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-EGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQ--QMSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 461
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Ngef (neuronal guanine nucleotide exchange factor [Source:MGI Symbol;Acc:MGI:1858414])

HSP 1 Score: 182.185 bits (461), Expect = 5.517e-47
Identity = 120/318 (37.74%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L +L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E        + I+ P + H +FSNV+ +M  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  251 LWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERL------KKILHPSEAHILFSNVLDVMAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-EGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 551
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef19 (Rho guanine nucleotide exchange factor (GEF) 19 [Source:MGI Symbol;Acc:MGI:1925912])

HSP 1 Score: 164.851 bits (416), Expect = 5.335e-41
Identity = 126/374 (33.69%), Postives = 186/374 (49.73%), Query Frame = 3 
Query: 1551 NQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQR-----MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQS-YVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKS-GRLLVLDYSNKANVTIETSSFK 2648
             Q  +E  P  G  G++     P+ N      +  +SS    R+ R     +W D+P+V  SG+L  LS  + +LQEA FE+ITSEASY  SL +   HF  S    +SE     +   DK  +FS +  +  TS   L+DLEQR  E   +   +CD+VL+H  +  F+  Y+ Y+ NQ YQ +  +R L EN  F   L++LE S  C +L L S+L+LP QR+TRLK+LVE + K +   G  +   E +   AF AL   K L+   N     M +   LI L  +I+F   +  +    R L+R  EL V             K     + L LFND L+++++K  G+  V  ++N A + +   S K
Sbjct:  309 RQQREEEGPGDGAEGAEEGPGPPRAN------LSPSSSFRAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGS--VELSE----CLGTQDKQWLFSKLPEVKSTSERFLHDLEQRL-EADVLRFSVCDVVLHHCPA--FRRVYLPYVTNQAYQERTYQRLLLENPKFPGILARLEESPVCQRLPLTSFLILPFQRVTRLKMLVENILK-RTAPGSQD---EDMATKAFSAL---KELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGEL-VELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHANMAELQVRDLSLK 659
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:MGI Symbol;Acc:MGI:2446219])

HSP 1 Score: 161.77 bits (408), Expect = 2.685e-40
Identity = 136/425 (32.00%), Postives = 209/425 (49.18%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLS-ENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTIETSSFKRNISSTEISRNTS---SFDV----NSESQSPIRII----GTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDI 2897
            +Y   Q  WS +PEV ESG+L  LS  E + QEA+FEI+TSE SY  SL IL   F        S +    ++  + HH+FSN++ +M  S      LEQR H+ +  + DI DI+ +H     F  Y+ Y  N+ YQ + L++LS  N  F+  L ++E    CG L + S+L+LPMQR+TRL LL + +        +  +        A  AL  I  L+   N     M++   + +L  ++ F   VKS+    + R LL+  EL +   + I   RKI+ +  P   L LFND+L++TKKKS    LV DY+   +V +        +     SR++S    F V    NSE +    ++     +   R  T+LT  ER+   +    +   +PQ+  T+ + F  Q   + L ++DI
Sbjct:  259 SYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQ------SRELRATMTQTEHHHLFSNILDVMSASQKFFEALEQR-HKAQVCVEDISDILEDHA-QHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLC-------LKTQGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDF-GKVKSLPLISASRWLLKRGELFLLEESSI--FRKIASR--PTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGI---TNKGELPQVEVTKAY-FAKQADEITLQQADI 659
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Match: Arhgef16 (Rho guanine nucleotide exchange factor (GEF) 16 [Source:MGI Symbol;Acc:MGI:2446219])

HSP 1 Score: 161.77 bits (408), Expect = 2.685e-40
Identity = 136/425 (32.00%), Postives = 209/425 (49.18%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLS-ENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTIETSSFKRNISSTEISRNTS---SFDV----NSESQSPIRII----GTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDI 2897
            +Y   Q  WS +PEV ESG+L  LS  E + QEA+FEI+TSE SY  SL IL   F        S +    ++  + HH+FSN++ +M  S      LEQR H+ +  + DI DI+ +H     F  Y+ Y  N+ YQ + L++LS  N  F+  L ++E    CG L + S+L+LPMQR+TRL LL + +        +  +        A  AL  I  L+   N     M++   + +L  ++ F   VKS+    + R LL+  EL +   + I   RKI+ +  P   L LFND+L++TKKKS    LV DY+   +V +        +     SR++S    F V    NSE +    ++     +   R  T+LT  ER+   +    +   +PQ+  T+ + F  Q   + L ++DI
Sbjct:  259 SYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQ------SRELRATMTQTEHHHLFSNILDVMSASQKFFEALEQR-HKAQVCVEDISDILEDHA-QHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLC-------LKTQGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDF-GKVKSLPLISASRWLLKRGELFLLEESSI--FRKIASR--PTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGI---TNKGELPQVEVTKAY-FAKQADEITLQQADI 659
[Close]
BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8CHT1|NGEF_MOUSE (Ephexin-1 OS=Mus musculus OX=10090 GN=Ngef PE=1 SV=1)

HSP 1 Score: 182.185 bits (461), Expect = 3.621e-46
Identity = 120/318 (37.74%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L +L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E        + I+ P + H +FSNV+ +M  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  251 LWQDLPEIQSSGVLDILQPEEIRLQEAMFELVTSEASYYKSLNLLVSHFMENERL------KKILHPSEAHILFSNVLDVMAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCKGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-EGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 551
[Close]
BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5BKC9|NGEF_RAT (Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE=1 SV=2)

HSP 1 Score: 181.415 bits (459), Expect = 6.437e-46
Identity = 120/318 (37.74%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L +L   E +LQEAMFE++TSEASYY+SL +L  HF  +E        + I+ P + H +FSNV+ +M  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L L S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  242 LWQDLPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSLNLLVSHFMENERL------KKILHPSEAHILFSNVLDVMAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITRLKLLV------QNILKRVEEGSER-EGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFREIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 542
[Close]
BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q8N5V2|NGEF_HUMAN (Ephexin-1 OS=Homo sapiens OX=9606 GN=NGEF PE=1 SV=2)

HSP 1 Score: 179.489 bits (454), Expect = 2.973e-45
Identity = 119/318 (37.42%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L++L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E          I+ P + H +FSNV+ ++  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  251 LWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERI------RKILHPSEAHILFSNVLDVLAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-ECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 551
[Close]
BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5RDX5|NGEF_PONAB (Ephexin-1 OS=Pongo abelii OX=9601 GN=NGEF PE=2 SV=1)

HSP 1 Score: 179.489 bits (454), Expect = 3.190e-45
Identity = 119/318 (37.42%), Postives = 179/318 (56.29%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQ-PLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W D+PE+  SG+L++L   EI+LQEAMFE++TSEASYY+SL +L  HF  +E          I+ P + H +FSNV+ ++  S   L +LE R  EE  V+SD+CDIV  +  +D F  Y+TY+ NQ YQ +  K+ L E   F++ +++LE   +C  L   S+L+LP QR+TRLKLLV      QNI     E SE  +  A  A  +++ ++   N     M +   +IS+  ++ F      I    R LL++ EL+    +G KT R +  KK    I L LFNDLL+I ++  G +  V D + +  + +E
Sbjct:  250 LWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERI------RKILHPSEAHILFSNVLDVLAVSERFLLELEHR-MEENIVISDVCDIVYRYA-ADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLV------QNILKRVEERSER-ECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQ--MSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVE 550
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BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Match: sp|Q5VV41|ARHGG_HUMAN (Rho guanine nucleotide exchange factor 16 OS=Homo sapiens OX=9606 GN=ARHGEF16 PE=1 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 7.964e-43
Identity = 120/326 (36.81%), Postives = 178/326 (54.60%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTIE 2633
            +Y   Q  WS +PEV E GIL  LS  E + QEAMFEI+TSE SY  SL IL + F        S++    V+ ++ HH+FSN++ ++  S     DLEQR H+ + ++ DI DI+  H     F  Y+ Y  N+ YQ + L++L S N  F++ L ++E    CG L + S+L+LPMQR+TRL LL++ +         T   SE  K  A  AL  I  L+   N     M++   + +L  ++ F   VKS+    + R LL+  EL +   TG+   RKI+ +  P   L LFND+L++TKKKS    +V DY+   ++ +E
Sbjct:  255 SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQ------SKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQR-HKAQVLVEDISDILEEHA-EKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCL------KTQGHSERYK-AASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDF-SKVKSLPLISASRWLLKRGELFLVEETGL--FRKIASR--PTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVE 560
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Match: A0A5K3EIW9 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 267.7 bits (683), Expect = 6.503e-70
Identity = 158/418 (37.80%), Postives = 226/418 (54.07%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETI-----------------------------------------------------VSPI----DKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNI--------------EGITNEISESVKN---------NAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTI--RKISKKKQPLIVLVLFNDLLIITK-KKSGRLLVLDYS--NKANVTIETSSFKRNISSTEISRNTSS 2690
            WS+MPEV    ++  ++++EIQLQEAMFE+ITSEASYYRSL +L +HF+ +  F  S    TI                                                     V P+    +KHH+FSNV+LI   S   L DLE RW  EKP+++++CD+++ H  S  F+ Y+TYLRNQ YQ  A +RL+  E F++ ++++ +    GK  LDS+L LPMQRLTRLKLLVE + K Q +              E +T   +E ++          NA IAL ++K LL+ S +EK  MD+K+ L++L + + FP NVK I  SD+ L++E ELR     G  T+  +K+ +KK     L+LFNDLL++TK KK+ R LV DY   +K  VTI   S     +ST I+  ++S
Sbjct:  465 WSEMPEVQTGNVIGTMTRHEIQLQEAMFEVITSEASYYRSLQVLIEHFYGAPEFDCSRSATTIPEESTNETDGECTSCQSGDASSFSKSASQNNALSGGSRTGSITGLGEVGPAPVVKPVLSPTEKHHLFSNVLLICMASERFLQDLEARWSSEKPLLNEVCDLIVKHAGSVHFEPYLTYLRNQTYQVAAYRRLNRREDFQKAIARMHAHPAVGKNHLDSFLALPMQRLTRLKLLVEVIQKLQAVVASDAEERAITGSTETMTPAATEGIRRMKITPQQQENASIALRELKRLLSESESEKKLMDEKARLLALSSALEFPENVKRIAISDKRLIKEGELRSATSDGKATVLLKKLGRKKPETFYLILFNDLLMVTKLKKNDRYLVQDYCPRDKVYVTIGNPS----DASTHITTGSAS 878
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Match: A0A158QGG3 (DH domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS32 PE=4 SV=1)

HSP 1 Score: 266.159 bits (679), Expect = 1.978e-69
Identity = 152/388 (39.18%), Postives = 217/388 (55.93%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKET-----------------------------------------------IVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQN----------IEGITNEISESVKN-------------NAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTI--RKISKKKQPLIVLVLFNDLLIITK-KKSGRLLVLDYS--NKANVTI 2630
            WS+MPEV    I+  +S++EIQLQEAMFE+ITSEASYYRSL +L +HF+S+  F  S+   T                                               ++SP +KHH+FSNV+LI   S   L DLE+RW  +KP+++++CD+++ H  S  F  Y+TYLRNQ YQ  A +RL+  E F++ ++++ +  E GK  LDS+L LPMQRLTRLKLLVE + K Q+          + G T  ++  V +             N  IAL ++K LL+ S +EK  MD+K+ L+ L + + FP NVK I  SD+ L++E ELR     G   +  +K+ +KK     L+LF+DLL++TK KK+ R LV DY   +K  VTI
Sbjct:  494 WSEMPEVLTGNIVSTMSRHEIQLQEAMFEVITSEASYYRSLQVLIEHFYSAPEFDCSKSAPTNADSFADNDSESNVPPSNESRQSSSGISTRAGSISSAADLGAPVVKAVLSPTEKHHLFSNVLLICMASERFLKDLEERWSSQKPLLNEVCDLIVKHAGSVQFDPYLTYLRNQTYQVAAYRRLNLREDFQKAIARMHAHPEVGKNRLDSFLALPMQRLTRLKLLVEVIQKLQSEVAMEAEKRAVAGSTETMTPGVCDSPRRMKITKEHLENTSIALRELKRLLSESESEKKLMDEKARLLELSSALEFPENVKRIAISDKRLVKEGELRSANSDGKAAVLLKKLGRKKPETFYLILFHDLLMVTKLKKNDRYLVQDYCPHDKVYVTI 881
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Match: A0A4S2LIW8 (DH domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_006871 PE=4 SV=1)

HSP 1 Score: 264.233 bits (674), Expect = 3.634e-69
Identity = 150/382 (39.27%), Postives = 216/382 (56.54%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSIS---------------------------------------EDKETIVS--------------PIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAF-------------IALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELR-VHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            WS+MPEV  S  L  L+++E+QLQEAMFE+ITSEASYY+SL +L KHF++S  FS                                          +  T++S              P++KHH+FSNV+L+   S   L DLE RW  + P+++++CD+++ H    +F+ Y+TYLRNQ YQ + L++L + + F+  L  L S    GK SL S+L LPMQRLTRLKLLVE + + Q  + +  E S+  K N+              +AL ++  LL +S TEK  MDQK+ L++L + + FP NVKSI  SD+ L++E E+R   P + I  ++K+S KK     L+LFNDLL++TKKK   R LVLDY ++A +  E
Sbjct:  299 WSEMPEVLNSDALMKLTRHEVQLQEAMFEVITSEASYYQSLNVLVKHFYNSPEFSYGSTAKGDLPTSPSQAVSLGISMAQIAGQLSYENGTDMPQESNPGTVISATPISGGTRRPLLKPLEKHHLFSNVLLVCLASEKFLKDLETRWVSQMPILNEVCDLIVKHAGGANFEPYITYLRNQAYQMETLRKLCQRDSFRSTLETLHSHPVSGKNSLGSFLALPMQRLTRLKLLVEVIRRLQ--DSVIQEASDPAKRNSPYRIPTDRERENVQLALRELSRLLASSETEKELMDQKARLLTLSSALEFPDNVKSIAISDKRLIKEGEVREAAPDSRISMLQKLSLKKPSSFYLILFNDLLLVTKKKKNERYLVLDYCDRAALQAE 678
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Match: A0A158QDA1 (DH domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS2662 PE=4 SV=1)

HSP 1 Score: 256.529 bits (654), Expect = 8.964e-69
Identity = 146/389 (37.53%), Postives = 216/389 (55.53%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFS--------------------------SELFSISEDKET------------------------IVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQN----------IEGITNEISESVKN-------------NAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTI--RKISKKKQPLIVLVLFNDLLIITK-KKSGRLLVLDYSNKANVTI 2630
            WS+MPEV    I+  ++++EIQLQEAMFE+ITSEASYYRSL +L +HF+S                          S +F  +E +++                         +SP +KHH+FSNV+LI   S   L DLE RW  +KP+++++CD+++ H  S  F  Y+TYLRNQ YQ  A +RL+  E F++ ++++ +    GK  LDS+L LPMQRLTRLKLLVE + K Q+          + G T  ++    +             N+ IAL ++K LL+ S +EK  MD+K+ L++L + + FP NVK I  SD+ L++E ELR     G   +  +K+ +KK     L+LF+DLL++TK KK+ R LV DY  +  V +
Sbjct:   75 WSEMPEVLAGNIIPTMTRHEIQLQEAMFEVITSEASYYRSLQVLIEHFYSAPEFDCSRSSTTSTDNSSSCADNDSESSVFPPNESRQSSSGINTRAGSITSTTDLGASVVKPALSPTEKHHLFSNVLLICMASERFLQDLEARWSSQKPLLNEVCDLIVKHAGSVQFDPYLTYLRNQTYQVAAYRRLNLREDFQKAIARMHAHPAVGKNRLDSFLALPMQRLTRLKLLVEVIQKLQSVVASDAEERAVAGSTETMTPGASDNSRRMKITKEQIENSSIALRELKRLLSESESEKKLMDEKARLLALSSALEFPENVKRIAISDKRLIKEGELRSASSDGKAAVLLKKLGRKKPESFYLILFHDLLMVTKLKKNDRYLVQDYCPREKVYV 463
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Match: A0A564YL12 (DH domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS7001 PE=4 SV=1)

HSP 1 Score: 256.914 bits (655), Expect = 3.796e-68
Identity = 154/408 (37.75%), Postives = 223/408 (54.66%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFS--------------------------SELFSISEDKET------------------------IVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQN----------IEGITNEISESVKN-------------NAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTI--RKISKKKQPLIVLVLFNDLLIITK-KKSGRLLVLDYS--NKANVTIETSS-FKRNISSTEISR 2678
            WS+MPEV    I+  ++++EIQLQEAMFE+ITSEASYYRSL +L +HF+S                          S +F  +E +++                         +SP +KHH+FSNV+LI   S   L DLE RW  +KP+++++CD+++ H  S  F  Y+TYLRNQ YQ  A +RL+  E F++ ++++ +    GK  LDS+L LPMQRLTRLKLLVE + K Q+          + G T  ++    +             N+ IAL ++K LL+ S +EK  MD+K+ L++L + + FP NVK I  SD+ L++E ELR     G   +  +K+ +KK     L+LF+DLL++TK KK+ R LV DY    K  VTI   +    NI    ISR
Sbjct:  167 WSEMPEVLAGNIIPTMTRHEIQLQEAMFEVITSEASYYRSLQVLIEHFYSAPEFDCSRSSTTSTDNSSSCADNDSESSVFPPNESRQSSSGINTRAGSITSTTDLGASVVKPALSPTEKHHLFSNVLLICMASERFLQDLEARWSSQKPLLNEVCDLIVKHAGSVQFDPYLTYLRNQTYQVAAYRRLNLREDFQKAIARMHAHPAVGKNRLDSFLALPMQRLTRLKLLVEVIQKLQSVVASDAEERAVAGSTETMTPGASDNSRRMKITKEQIENSSIALRELKRLLSESESEKKLMDEKARLLALSSALEFPENVKRIAISDKRLIKEGELRSASSDGKAAVLLKKLGRKKPESFYLILFHDLLMVTKLKKNDRYLVQDYCPREKVYVTIGNPTEAALNILGANISR 574
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: si:dkey-38p12.3 (rho guanine nucleotide exchange factor 15-like [Source:NCBI gene;Acc:103030780])

HSP 1 Score: 174.481 bits (441), Expect = 9.852e-44
Identity = 119/320 (37.19%), Postives = 182/320 (56.88%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSE-NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIIT-KKKSGRLLVLDYSNKANVTIET 2636
            +W D+P V ESGIL+ L+  E + QE+MFE++TSE SY RSL +LT+HF  S      E  +T++  +DK  +FSN++ I + S   L DLE R  E   V+SDICDI+  H    +F +Y+ Y+RNQ YQ +    L + N  F   +S+L+ S  C +L   S+L+LP QR+TR+K+LVE + K + +EG   E S      A  AL  +  ++   N++ G M Q   LI  IN++     +K++      R L +  EL      G  T+  +  K  P + L LFNDLL++  KK S R +V+D+++++ V ++ 
Sbjct:  551 LWQDLPSVKESGILQKLTPEECKYQESMFEVMTSEVSYLRSLRVLTEHFLESR-----ELNDTLIV-LDKKTLFSNILRIREVSEKFLKDLENRLDESL-VVSDICDIISYHA-QHNFPAYIDYVRNQIYQDKTYSTLMQTNTQFATVISRLQESPRCQRLPFMSFLLLPFQRITRIKILVENILK-RTVEGTDKEES------ASKALSAVSKIIEECNSQVGKMKQMEELIE-INKMLEFDKLKAVPIISQTRFLEKRGELLEVAKGG--TLFNLKPKFTP-VCLFLFNDLLVLANKKGSERYVVIDHAHRSLVQVQA 851
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:103040535])

HSP 1 Score: 162.925 bits (411), Expect = 5.491e-41
Identity = 111/317 (35.02%), Postives = 176/317 (55.52%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTI 2630
            WS +P V E GIL+ +S  E + QE +FEI+TSE SY  SL IL +H      F  S+D    ++  + HH+FSN+ +I   S     +LE+R H+  PV+ DI DIV ++  ++ F+ Y+ Y  N+ +Q + L++ L+ N  FK+ L K+ESS ECG L + S+L+LPMQR TRL LL++ + + +  +  TN  +      A  AL +I  L+ + N     M++   + ++  ++ F   +K      + R LL++ EL ++        +  S K   L V   FND+LI+TK+KS    +V DY+   NV +
Sbjct:  237 WSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILVRH------FKASDDLRKAMTATEHHHLFSNISVIQAVSKRFFEELERR-HQLDPVIKDISDIVQDYA-ANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTICQ-KTPKQTTNYYA------ARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEF-GRIKPFPLVSASRWLLKKGELAINLEELGLFWKAFSHKSYWLFV---FNDVLIVTKRKSEESYVVCDYATLENVEV 534
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:103040535])

HSP 1 Score: 162.925 bits (411), Expect = 5.491e-41
Identity = 111/317 (35.02%), Postives = 176/317 (55.52%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYSNKANVTI 2630
            WS +P V E GIL+ +S  E + QE +FEI+TSE SY  SL IL +H      F  S+D    ++  + HH+FSN+ +I   S     +LE+R H+  PV+ DI DIV ++  ++ F+ Y+ Y  N+ +Q + L++ L+ N  FK+ L K+ESS ECG L + S+L+LPMQR TRL LL++ + + +  +  TN  +      A  AL +I  L+ + N     M++   + ++  ++ F   +K      + R LL++ EL ++        +  S K   L V   FND+LI+TK+KS    +V DY+   NV +
Sbjct:  237 WSQLPVVQEMGILETISPEERKRQEVIFEIMTSEYSYLHSLSILVRH------FKASDDLRKAMTATEHHHLFSNISVIQAVSKRFFEELERR-HQLDPVIKDISDIVQDYA-ANHFKPYIVYCSNETFQQRTLQKLLASNTAFKEVLKKIESSPECGGLPMISFLILPMQRATRLPLLMDTICQ-KTPKQTTNYYA------ARWALKEISKLVKSCNDGARRMERTEQMYTIQKQMEF-GRIKPFPLVSASRWLLKKGELAINLEELGLFWKAFSHKSYWLFV---FNDVLIVTKRKSEESYVVCDYATLENVEV 534
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:103044275])

HSP 1 Score: 157.147 bits (396), Expect = 1.959e-38
Identity = 107/308 (34.74%), Postives = 172/308 (55.84%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYS 2609
            WS +  V +S   K LS+ E + QEA+FE+I+SE SY  SLMIL +      LF  S++    ++  D HH+FSN++ + +TS     +LE R H++  V+ DI DIV+ H  S+ F+ YVTY  N+ YQ + L+RL S+N  FK+ L+++E+ S+C  L + S+L+LPMQR+TRL LLV+ +   Q     + +  E  K     AL  +  L+   N     M++   + ++ +++ F      +  S R +++  EL  +         K   ++Q  +   LFND+LI+T+KKS     V+DY+
Sbjct:  444 WSQLSVVKKSEAAKKLSQEERKRQEAIFEVISSEHSYLHSLMILIR------LFKDSQELSETMTKTDHHHLFSNIVDVCETSKKFFKELEDR-HQQNIVIDDISDIVIRHAQSN-FEPYVTYCSNEVYQQRTLQRLLSKNPSFKEVLNRIETHSDCRNLPMCSFLILPMQRVTRLPLLVDTIC--QKTPKDSPQYEECKK-----ALHCVSKLVRKCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWMVKRGELTAYSEEKNSIFSKRMSRQQ--VYFFLFNDVLIVTRKKSEESYTVIDYA 734
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Match: ARHGEF26 (Rho guanine nucleotide exchange factor 26 [Source:NCBI gene;Acc:103044275])

HSP 1 Score: 150.214 bits (378), Expect = 2.544e-36
Identity = 102/293 (34.81%), Postives = 165/293 (56.31%), Query Frame = 3 
Query: 1737 LSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRL-SENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGR-LLVLDYS 2609
            LS+ E + QEA+FE+I+SE SY  SLMIL +      LF  S++    ++  D HH+FSN++ + +TS     +LE R H++  V+ DI DIV+ H  S+ F+ YVTY  N+ YQ + L+RL S+N  FK+ L+++E+ S+C  L + S+L+LPMQR+TRL LLV+ +   Q     + +  E  K     AL  +  L+   N     M++   + ++ +++ F      +  S R +++  EL  +         K   ++Q  +   LFND+LI+T+KKS     V+DY+
Sbjct:  409 LSQEERKRQEAIFEVISSEHSYLHSLMILIR------LFKDSQELSETMTKTDHHHLFSNIVDVCETSKKFFKELEDR-HQQNIVIDDISDIVIRHAQSN-FEPYVTYCSNEVYQQRTLQRLLSKNPSFKEVLNRIETHSDCRNLPMCSFLILPMQRVTRLPLLVDTIC--QKTPKDSPQYEECKK-----ALHCVSKLVRKCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWMVKRGELTAYSEEKNSIFSKRMSRQQ--VYFFLFNDVLIVTRKKSEESYTVIDYA 684
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000490.1 (pep scaffold:Pmarinus_7.0:GL477825:44699:67115:1 gene:ENSPMAG00000000430.1 transcript:ENSPMAT00000000490.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 141.354 bits (355), Expect = 1.963e-35
Identity = 106/342 (30.99%), Postives = 184/342 (53.80%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSE-NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKT-LLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFND-LLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDV 2699
            +W  +P V  SG+L  LS +  + QEAMFE++TSEASY +S+ I+T  F +SE  + + + E+      K  ++S++  + K + + + +L  R  +   ++SDICDIV  +   DDF+ Y+ YL N +YQ +    L E N  F   + +L+   +CG+L   S+L LP+QR+TRL+LL+E +  +         +   +     + L   +T ++  SN     M Q   +I++  +I F  NVK+I     +R L+++ E+      G      IS++K   I + LFND LL+ +KK+  + +V+D+ ++A + ++ +      S TE++   S F V
Sbjct:   75 LWQHLPHVIASGVLASLSGDAKKQQEAMFEVLTSEASYLKSISIVTDFFMTSEELNQTLNMES------KKALYSSIADVKKVTESFIAELGDRI-DSDILISDICDIVYKYA-RDDFKVYIPYLTNNRYQEKKFIELRESNSQFSAAVQRLQEMPQCGRLPFTSFLHLPLQRITRLRLLLENLMSYH--------VQHRLWYRDRVVLVASRTQVIKESNESVRKMQQVEEMINICQQIVF-ENVKTIGLISKNRWLVKQGEVMELTQRGTMI---ISRQKATPIHMFLFNDMLLLCSKKREHKFVVVDHVHRAMLQVKPN------SDTEVANKNSFFLV 390
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007206.1 (pep scaffold:Pmarinus_7.0:GL501079:1421:14838:1 gene:ENSPMAG00000006509.1 transcript:ENSPMAT00000007206.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 80.8777 bits (198), Expect = 1.586e-16
Identity = 60/178 (33.71%), Postives = 98/178 (55.06%), Query Frame = 3 
Query: 2118 FKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFI--ALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKK----QPLIVLVLFNDLLII-TKKKSGRLLVLDYSNKANV 2624
            F  ++  LE +  C KL   S+L +P QR+TR +LLV+          + ++  ESV++   +  AL K++ L+  S+   G   Q   ++++ N IYF   +KS+      R LL+  +L V      KTI  ++  +    +  ++L+LFND LI+ TK+K GRLLVLDY+++A V
Sbjct:    6 FSSKIKLLEEAPVCEKLPFLSFLSVPYQRITRYQLLVK---------NVISKAEESVESGNVVELALSKLEELVQQSDKGVGERTQAEQVVNIANNIYFEKGMKSLAIVSQSRSLLKSGKLLVQEKA--KTIIPMAVARFTQGKTYVMLLLFNDFLIVATKQKGGRLLVLDYADRAFV 172
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009516.1 (pep scaffold:Pmarinus_7.0:GL478064:31675:37139:1 gene:ENSPMAG00000008606.1 transcript:ENSPMAT00000009516.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.5438 bits (153), Expect = 8.545e-11
Identity = 55/194 (28.35%), Postives = 92/194 (47.42%), Query Frame = 3 
Query: 2109 NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREE---ELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKK--SGRLLVLDYSNKANVTIETSSFKRNISSTE 2669
            N  F   L  L+    C +LSL S+L+LP QR+ R+K+L+E + K         E     +  A +AL  +  L+   N     M +   LI L N I F   +KS+      R L++     EL V    G   + ++  K+   I L LFND+LI++++K   G+  V  ++++  V +++     N  +T+
Sbjct:    2 NAKFSPLLEHLQEDPICNRLSLQSFLILPFQRIVRIKILLENILK-------KTEPHSRYEETASVALKALARLIQECNENARKMKRTEELIHLHNTIEF-DKMKSLALISPTRWLVKHGELLELAVSRTAGSTLMNRLMTKR---IYLHLFNDILILSRRKDSGGKFTVFCHADRTKVELQSVGAAENNVATD 184
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000080.1 (pep scaffold:Pmarinus_7.0:GL476403:365803:389077:1 gene:ENSPMAG00000000073.1 transcript:ENSPMAT00000000080.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.521 bits (114), Expect = 5.290e-6
Identity = 60/269 (22.30%), Postives = 120/269 (44.61%), Query Frame = 3 
Query: 2034 DDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREE-ELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKK----SGRLLVLDYSNKANVTIETSSFKRNISSTEISR-NTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSM 2822
            +DFQ Y  Y +N+       ++ ++  +F++   +L+      KL+LDSYL+ P+QR+T+ +LL++ + K       T E+ E        AL  + ++L   N     M Q    I++     F  +V+ +    R+L++    +      G   ++++++ K     L L+  LL+  K++     G      YS K  + ++       +  TE+S+ +   F+V+   +  +  I  + +  KT+   + RK L+  L      M
Sbjct:   25 EDFQIYEKYCQNKPRSEAVWRQFADAAFFQECQRRLDH-----KLALDSYLLKPVQRITKYQLLLKEMLKCSKNSAGTQELEE--------ALAGMLSILKAVNDS---MHQ----IAITG---FEGDVRDL---GRLLMQGAFSVWAESRKGHSKVKELARFKPMQRHLFLYPKLLLFCKRREETGEGYEKAPSYSFKHALKMD------GVGITEVSKGDQKKFEVSYNGREEVYTIQASSVEVKTAWVHEIRKVLTSQLEACKGQM 261
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Match: net1 (neuroepithelial cell transforming 1 [Source:ZFIN;Acc:ZDB-GENE-041121-18])

HSP 1 Score: 48.9062 bits (115), Expect = 5.405e-6
Identity = 45/187 (24.06%), Postives = 82/187 (43.85%), Query Frame = 3 
Query: 1677 RNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAV 2237
            RN R+WS   E  ++G  +  S++EI+ QEA+FE+   E      L +  K +    L      K +I++ ++   IF  +  ++    +LL  L Q+  +       +  I++  +      +Y  Y  NQ      L +  ++   +  L +   S    KL L S+L +P  RL +  LL+  +
Sbjct:   88 RNSRLWS---ETYDAGAHEAFSRSEIKRQEAIFELAQGEQDLIEDLKLAKKAYRDPML------KLSIMTAVELAQIFGALDSLIPLHEDLLTGL-QKARKPNGATERVGHILVEWLPC--LNAYTCYCANQVAAKALLDQKKQDPRVQDFLQRCLESPFSRKLELWSFLDVPRSRLVKYPLLLREI 262
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Yeast
Match: ROM1 (Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication [Source:SGD;Acc:S000003302])

HSP 1 Score: 48.9062 bits (115), Expect = 6.719e-6
Identity = 49/178 (27.53%), Postives = 83/178 (46.63%), Query Frame = 3 
Query: 1737 LSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKH-----HIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHV-ISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQN 2252
            LSK +I+ QEA++E+ T+E  + +SL I+   F    L       ET + P D       H+F+++  I   +   L  L QR     P+   I DI L ++   D F SY+      +Y  +  + ++ N  F +   ++ +SS   +  +DS+L   + R  R  LLV  +  F +
Sbjct:  458 LSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLL-------ETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQR-QSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPN--FARFDDEVSNSSL--RHGIDSFLSQGVSRPGRYSLLVREIIHFSD 623
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO39595 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9L2])

HSP 1 Score: 159.073 bits (401), Expect = 2.139e-41
Identity = 112/318 (35.22%), Postives = 172/318 (54.09%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIETS 2639
            +W ++PEV +SG+L+ +   E + QEAMFE+ITSEASY +SL IL  HF  S     ++  +++V    +  +F NV  +++ S   L  L QR   +  V+S I DI+  H  +  F  Y+ Y  +Q YQ + LK L +N  F + + +LE  S    LS  S+L+LPMQR+TRL LLV+A+      E  ++E   + K     AL  I  +++  N     M++   LI+L   I F     ++  S+R LLR  E+ +        +RK  K K   + + LFNDLL++ KKKS  +  VLDY+N+    +E +
Sbjct:    2 LWCELPEVMKSGVLETIDPTERKRQEAMFEVITSEASYLKSLNILGSHFMDSPELQ-ADTAQSVVEKSQQRVLFGNVKGVLEASEKFLTALRQR-QRKSYVISTISDIIEEHA-TQYFDIYIKYCSHQVYQDRILKELGKNPRFVEAVRRLEQCSTAQCLSFQSFLVLPMQRITRLPLLVDAIC--HRCEEGSDEFVRTDK-----ALKSINKVVHDCNEGARKMERMEELIALQPLIEFAVKPVALVSSNRWLLRRGEVLLVTEEFKSPLRKKIKTKP--VYMFLFNDLLLMCKKKSDIKYRVLDYANRNMTKVEVA 307
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Nematostella
Match: EDO39608 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9N2])

HSP 1 Score: 56.225 bits (134), Expect = 9.718e-8
Identity = 60/234 (25.64%), Postives = 112/234 (47.86%), Query Frame = 3 
Query: 1725 ILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDL-----EQRWHEEKPVMSDICDIVLNHVISDD-FQSYVTYLRNQQYQTQALK-RLSENEYFKQQLSKLESSSEC-GKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRI 2402
            I++ ++K +   QEA++E++ +E +Y   L I+ K F    L   +   E  +  ++   +FSN+  I + + +   D      E+     KP+  +  D+     + D  F+ Y+TY   +    +  K ++ ENE F+  ++  E    C  +L L  YL+ PMQRLT+  LL++A+ K            E +K   +  +  +++LL+  N     M +++ L S+ NRI
Sbjct:  406 IMETMTKKQKDQQEAIWELLFTEVTYIHKLSIVKKLFI---LCLRNVQSEGFLLDVEIEKLFSNIEDIYELNYSFWVDCLCEVAEKSRKTGKPL--NPMDMNEAFPMFDKRFEPYITYCMEESRCLKYFKEKIIENEDFRTYITWCEEHRLCTNRLKLTDYLVKPMQRLTKYPLLLKAIHKKTQ--------DEEMKEGIWKMILTVESLLSKVNGAMREMYERNKLRSVANRI 626
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:101175237])

HSP 1 Score: 174.096 bits (440), Expect = 1.903e-44
Identity = 117/326 (35.89%), Postives = 181/326 (55.52%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRL-LVLDYSNKANVTIE 2633
            NY   Q  WS +P+V  S IL  ++  E + QEA+FEII SE SY  SL IL +HF +S+  S +      ++P + HH+FSN+ +I+K S     DLE+R H+E  V+ DI DI+ NH  +  F+ Y+ Y  N+ +Q +  ++ L+ N  FK+ L +LESSSECG L + S+L+LPMQR+TRL LL++ +   Q     T E   +V      AL  +  L+ + N     M++   + ++  ++ F   +K      S R L +  EL +     +   +  + +      L LFND+LI+TKKK+  + +VLDY+   NV +E
Sbjct:  252 NYKPAQLTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHFKNSKTLSKT------MAPTEHHHLFSNISVILKVSQRFFEDLERR-HQEDVVIRDISDIIQNHA-AHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTIC--QKTPENTAEYFAAV-----WALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDF-GKIKPFPLVSSSRWLKKRGELNISAEE-LSIWKAFTNRS---YYLFLFNDVLIVTKKKTEEIFVVLDYATLENVEVE 557
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Match: arhgef16 (rho guanine nucleotide exchange factor 16 [Source:NCBI gene;Acc:101175237])

HSP 1 Score: 174.096 bits (440), Expect = 1.903e-44
Identity = 117/326 (35.89%), Postives = 181/326 (55.52%), Query Frame = 3 
Query: 1668 NYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITF--SDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRL-LVLDYSNKANVTIE 2633
            NY   Q  WS +P+V  S IL  ++  E + QEA+FEII SE SY  SL IL +HF +S+  S +      ++P + HH+FSN+ +I+K S     DLE+R H+E  V+ DI DI+ NH  +  F+ Y+ Y  N+ +Q +  ++ L+ N  FK+ L +LESSSECG L + S+L+LPMQR+TRL LL++ +   Q     T E   +V      AL  +  L+ + N     M++   + ++  ++ F   +K      S R L +  EL +     +   +  + +      L LFND+LI+TKKK+  + +VLDY+   NV +E
Sbjct:  252 NYKPAQLTWSQLPQVKNSDILSRITPQERKRQEAIFEIICSEHSYLHSLGILVRHFKNSKTLSKT------MAPTEHHHLFSNISVILKVSQRFFEDLERR-HQEDVVIRDISDIIQNHA-AHHFEPYIAYCSNETFQQRTHQKLLNTNSAFKEALKQLESSSECGGLPMFSFLILPMQRVTRLPLLLDTIC--QKTPENTAEYFAAV-----WALHAMSKLVTSCNDGARRMERTEQMYTIQKQMDF-GKIKPFPLVSSSRWLKKRGELNISAEE-LSIWKAFTNRS---YYLFLFNDVLIVTKKKTEEIFVVLDYATLENVEVE 557
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Match: ngef (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:101175182])

HSP 1 Score: 163.696 bits (413), Expect = 2.025e-42
Identity = 121/318 (38.05%), Postives = 180/318 (56.60%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKR-LSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIE 2633
            +W ++  V  SG+L  LS+NEI++QEAMFE++TSEASYY+SL IL  HF  +            +S  D H +FSN+  +M+ S   L DLE R  EE  ++SD+CDIV +H     F+ ++TY+ NQ YQ +  +R L EN+ F++ +++LE  S    LS  S+L+LP QR+TRLKLLV      QNI     E SE  + NA  A  +++ ++   N     M +   LIS+   + F      I    R LL++ E+++    G K+ + +  +K  QP I L LFN+LL+ITK+   +  VLD   +A +  E
Sbjct:   55 LWQNLEAVQSSGLLSRLSQNEIRMQEAMFELVTSEASYYKSLEILETHFLRNPRLI------NTLSQSDTHFLFSNIEEVMEASERFLMDLEHRI-EEAILISDVCDIVFHHA-EKHFKVFITYVINQVYQEKTYRRILEENQAFRETMAELEKHSCVRGLSFTSFLILPFQRITRLKLLV------QNILKTAEEHSER-ETNAIKAHQQLEQIVQECNEGVRKMSRTEELISIEKTLEFKTKSVPIISHSRWLLKKGEVQL--MCGPKSTKTMRSRKLHQP-ICLFLFNNLLLITKRSGDKFQVLDSCTRAMLRTE 354
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Match: si:dkey-38p12.3 (ephexin-1 [Source:NCBI gene;Acc:101161585])

HSP 1 Score: 161.384 bits (407), Expect = 1.050e-39
Identity = 108/316 (34.18%), Postives = 177/316 (56.01%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPI--DKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSE-NEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIIT-KKKSGRLLVLDYSNKANV 2624
            +W D+P+V ESG+L+ L+  + + QE+MFE++TSE SY RSL +LT+HF         E++E   + I  D   +FSN++ + + S   L DLE R  ++  V  DICDI+  H    +F +Y+ Y+RNQ YQ +    L + N  F   +++L+ S +C +L   S+L+LP QR+TR+K+L+E + K +  EG   E S S       AL+ +  +++  NTE G M Q   LI +   + F   +K++    +    E+   +   +   T+  +  K  P +   LFNDLL+I  KK S R +V+D+++++ V
Sbjct:  497 LWQDLPQVRESGVLETLTPEQCKYQESMFEVLTSETSYLRSLHVLTEHFL--------ENRELGEALIIRDTKTLFSNILRVREVSERFLKDLEDRVFQDI-VFPDICDIIHYHS-QHNFPAYIDYVRNQIYQEKTYAVLMKTNAQFAAVIARLQESPQCQRLPFVSFLLLPFQRITRIKMLIENILK-RTKEGTKEEQSASK------ALESVSKIISECNTEVGKMRQMEELIEVSKTLEF-DKLKAVPIISQNRYLEKRGDLQEMSKGATLFNVRGKFSP-VHFFLFNDLLVIAVKKGSERFVVIDHAHRSLV 793
[Close]
BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Match: ngef (neuronal guanine nucleotide exchange factor [Source:NCBI gene;Acc:101175182])

HSP 1 Score: 155.606 bits (392), Expect = 5.770e-39
Identity = 117/320 (36.56%), Postives = 176/320 (55.00%), Query Frame = 3 
Query: 1689 MWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGF--MDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKK--QPLIVLVLFNDLLIITKKKSG-RLLVLDYSNKANVTIE 2633
            +W ++  V  SG+L  LS+NEI++QEAMFE++TSEASYY+SL IL  HF  +            +S  D H +FSN+  +M+ S   L DLE R  EE  ++SD+CDIV +H     F+ ++TY+ NQ YQ +  +R+ EN+ F++ +++LE  S    LS  S+L+LP QR+TRLKLLV      QNI     E SE  + NA  A  +++         +G   M +   LIS+   + F      I    R LL++ E+++    G K+ + +  +K  QP+ + +  N LLI    KSG +  VLD   +A +  E
Sbjct:  152 LWQNLEAVQSSGLLSRLSQNEIRMQEAMFELVTSEASYYKSLEILETHFLRNPRLI------NTLSQSDTHFLFSNIEEVMEAS-EFLMDLEHRI-EEAILISDVCDIVFHHA-EKHFKVFITYVINQVYQEKTYRRIEENQAFRETMAELEKHSCVRGLSFTSFLILPFQRITRLKLLV------QNILKTAEEHSER-ETNAIKAHQQLEQSQIVQECNEGVRKMSRTEELISIEKTLEFKTKSVPIISHSRWLLKKGEVQL--MCGPKSTKTMRSRKLHQPICLFLFNNLLLIT---KSGDKFQVLDSCTRAMLRTE 450
[Close]
BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 1411.36 bits (3652), Expect = 0.000e+0
Identity = 761/800 (95.12%), Postives = 762/800 (95.25%), Query Frame = 3 
Query:  789 DTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAEXXXXXXXXXXXXXXXXXXEGDSDVETCQQADSISDTIDNEKYSEKYLHYKLENAENFEIHYRTAKESLSFINTVTNADIEIGKLVVPVNKHFSXXXXXXXXXXXXXXXXXXXIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNXXXXXXXXXXXXXLNEIXXXXXQFIETVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLMVRTN 3188
            DTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAENLLRKSKLNNNNNNSQLSEGDSDVETCQQADSISDTIDNEKYSEK                 TAKESLSFINTVTNADIEIGKLVVPVNKHFSDFNKNNNALDDNFNLKKDDIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNKKPKE                   I+TVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIK LLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLM RTN
Sbjct:   22 DTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAENLLRKSKLNNNNNNSQLSEGDSDVETCQQADSISDTIDNEKYSEK-----------------TAKESLSFINTVTNADIEIGKLVVPVNKHFSDFNKNNNALDDNFNLKKDDIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNKKPKE-------------------IKTVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLMNRTN 785
[Close]
BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 1359.74 bits (3518), Expect = 0.000e+0
Identity = 736/778 (94.60%), Postives = 739/778 (94.99%), Query Frame = 3 
Query:  777 FVDSDTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAEXXXXXXXXXXXXXXXXXXEGDSDVETCQQADSISDTIDNEKYSEKYLHYKLENAENFEIHYRTAKESLSFINTVTNADIEIGKLVVPVNKHFSXXXXXXXXXXXXXXXXXXXIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNXXXXXXXXXXXXXLNEIXXXXXQFIETVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDD 3110
             + +DTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAENLLRKSKLNNNNNNSQLSEGDSDVETCQQADSISDTIDNEKYSEK                 TAKESLSFINTVTNADIEIGKLVVPVNKHFSDFNKNNNALDDNFNLKKDDIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNKKPKE                   I+TVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIK LLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDD
Sbjct:   18 MLHNDTEYLPITNYNSENINGTFLIEKSRYTEIIFDNSPDPTVTDAENLLRKSKLNNNNNNSQLSEGDSDVETCQQADSISDTIDNEKYSEK-----------------TAKESLSFINTVTNADIEIGKLVVPVNKHFSDFNKNNNALDDNFNLKKDDIVEEYEEISDNEINQSIYDESKEQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNKKPKE-------------------IKTVSYVKGIDDINQTIQETFPIYGKRGSKNSENDPQVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDD 759
[Close]
BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000056271.1 (SMESG000056271.1)

HSP 1 Score: 956.436 bits (2471), Expect = 0.000e+0
Identity = 473/476 (99.37%), Postives = 474/476 (99.58%), Query Frame = 3 
Query: 1761 QEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLMVRTN 3188
            Q+AMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIK LLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLM RTN
Sbjct:    5 QQAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKKLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTEISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTSMPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDKDNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGITDEILAQSEIAQDWSDEFLMNRTN 480
[Close]
BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000044434.1 (SMESG000044434.1)

HSP 1 Score: 246.899 bits (629), Expect = 4.004e-68
Identity = 140/340 (41.18%), Postives = 210/340 (61.76%), Query Frame = 3 
Query: 1674 SRNQRMWSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQS-YVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKF-QNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHP-YTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKS-GRLLVLDYSNKANVTIETS-SFKRNISSTEISR 2678
            + N+  WS+M EV  SG+L  + K EI LQEA+FE+ITSEASY  SL  L ++++ +EL + +   ++I++P++KHH+FSN++LI   SL LL DLE RW ++KP M D+ DI+L H    DFQ  Y+ YL NQ YQ  ALK L + E FKQ L  ++S+ +C KLSLDS+L LPMQRLTRLKLL E +SK  +  + +   I + V  N   AL+K++ LL+     K  M+QK+ LI L   + F  + + +      L+++ E+R          ++K+SKK+QP   L++ ++L+I  KKKS  + +VL++  ++ V       F  +IS  + SR
Sbjct:  397 ASNRLYWSNMDEVKSSGVLSAMKKEEIHLQEAIFEVITSEASYNISLDTLIEYYYKNELLN-ANKHDSIINPVEKHHLFSNILLIKTVSLKLLKDLESRWSQQKPKMVDLADIILKHAEDKDFQQQYIFYLTNQSYQINALKALLQKEVFKQALYTIQSNPQCCKLSLDSFLALPMQRLTRLKLLTEVISKLMKQSKDLYETIPKEVVENNRKALEKLRELLSACEENKFKMEQKARLIDLCKFLEFRNSSRHVAIGSMDLIKDGEVRAAANQISSNALKKLSKKRQPTFYLIILSELVIFAKKKSQTKFVVLEHCPRSKVQASIHVDFATSISGPKASR 735
[Close]
BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Match: SMESG000003812.1 (SMESG000003812.1)

HSP 1 Score: 120.553 bits (301), Expect = 1.042e-27
Identity = 106/345 (30.72%), Postives = 187/345 (54.20%), Query Frame = 3 
Query: 1692 WSDMPEVNESGILKVLSKNEIQLQEAMFEIITSEASYYRSLMILTKHFFSSELFSISEDK--ETIVSPIDKHHIFSNVILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRNQQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLKLLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQKSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKKKQPLIVLVLFNDLLIITKKKSGRLL---VLDYSNKANVTIETSSFKRNIS----STEISRNTSSFDV 2699
            W +  +V   G+ K + K EI+ QE+ FEII+SEASY RSL +L   F+++   S+ E    + I+ P  K H+FSN++ I   S   L DLE+R+ E   + +D+ DIV  + + ++F  YV Y++NQ++Q++A   L +     + + +LES  EC  LSLDS+L+LPMQRL R+ LL++AV    N +     + E V      A+  I+ +++  +  K ++D++  ++ +I  + F P  K      +++   E  R +     K + +  K K+     +L ++ L++TK   G+ +   V DY + + + +E  + + N +      +I+RN+   DV
Sbjct:  222 WIETEQVKSKGLAKNMKKEEIKFQESQFEIISSEASYNRSLSVLIDKFYNAPQMSLVETNGIKPIIKPYQKEHLFSNILKIYTISCKFLADLERRFCESAKI-TDLSDIVTKYAV-NEFDVYVPYIQNQRFQSEAYNELKKEIATAKIIEELESQPECCSLSLDSFLLLPMQRLLRILLLLKAVR--TNAQPQQKHVIELVDK----AIQYIEKIIHKCSENKNYIDERQRMMEIIRHLDFKPGKKIKEQLGKLIHEGEVKRSNKNPSKKFMSESMKFKE--FWFILTSEYLLMTKLSKGKEVTYNVDDYCSSSEIFVEYETIEENGNIFQFKLQINRNSDVCDV 556
The following BLAST results are available for this feature:
BLAST of Guanine nucleotide exchange factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NGEF2.661e-4637.42neuronal guanine nucleotide exchange factor [Sourc... [more]
NGEF6.192e-4637.42neuronal guanine nucleotide exchange factor [Sourc... [more]
ARHGEF161.658e-4336.81Rho guanine nucleotide exchange factor 16 [Source:... [more]
ARHGEF192.499e-3932.35Rho guanine nucleotide exchange factor 19 [Source:... [more]
ARHGEF161.193e-3535.27Rho guanine nucleotide exchange factor 16 [Source:... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ephx-11.554e-3934.23EPHeXin (Eph-interacting GEF) homolog [Source:Uni... [more]
ephx-11.753e-3934.23EPHeXin (Eph-interacting GEF) homolog [Source:Uni... [more]
ephx-19.147e-3933.82EPHeXin (Eph-interacting GEF) homolog [Source:Uni... [more]
ephx-11.023e-3833.82EPHeXin (Eph-interacting GEF) homolog [Source:Uni... [more]
rhgf-12.582e-724.21RHo Guanine nucleotide exchange Factor [Source:Un... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Exn1.807e-3531.36gene:FBgn0261547 transcript:FBtr0302647[more]
Exn1.807e-3531.36gene:FBgn0261547 transcript:FBtr0302648[more]
Exn1.807e-3531.36gene:FBgn0261547 transcript:FBtr0302649[more]
Exn4.360e-3531.64gene:FBgn0261547 transcript:FBtr0302651[more]
Exn4.360e-3531.64gene:FBgn0261547 transcript:FBtr0302650[more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
arhgef151.799e-4333.33Rho guanine nucleotide exchange factor (GEF) 15 [S... [more]
arhgef159.468e-4234.58Rho guanine nucleotide exchange factor (GEF) 15 [S... [more]
arhgef161.957e-4035.74Rho guanine nucleotide exchange factor (GEF) 16 [S... [more]
arhgef162.328e-4035.74Rho guanine nucleotide exchange factor (GEF) 16 [S... [more]
ngef1.504e-3836.06neuronal guanine nucleotide exchange factor [Sourc... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NGEF1.943e-4738.13neuronal guanine nucleotide exchange factor [Sourc... [more]
NGEF3.858e-4738.56neuronal guanine nucleotide exchange factor [Sourc... [more]
NGEF4.699e-4738.13neuronal guanine nucleotide exchange factor [Sourc... [more]
arhgef161.234e-4638.87Rho guanine nucleotide exchange factor 16 [Source:... [more]
arhgef161.524e-4638.87Rho guanine nucleotide exchange factor 16 [Source:... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ngef2.458e-4737.74neuronal guanine nucleotide exchange factor [Sourc... [more]
Ngef5.517e-4737.74neuronal guanine nucleotide exchange factor [Sourc... [more]
Arhgef195.335e-4133.69Rho guanine nucleotide exchange factor (GEF) 19 [S... [more]
Arhgef162.685e-4032.00Rho guanine nucleotide exchange factor (GEF) 16 [S... [more]
Arhgef162.685e-4032.00Rho guanine nucleotide exchange factor (GEF) 16 [S... [more]
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BLAST of Guanine nucleotide exchange factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8CHT1|NGEF_MOUSE3.621e-4637.74Ephexin-1 OS=Mus musculus OX=10090 GN=Ngef PE=1 SV... [more]
sp|Q5BKC9|NGEF_RAT6.437e-4637.74Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE... [more]
sp|Q8N5V2|NGEF_HUMAN2.973e-4537.42Ephexin-1 OS=Homo sapiens OX=9606 GN=NGEF PE=1 SV=... [more]
sp|Q5RDX5|NGEF_PONAB3.190e-4537.42Ephexin-1 OS=Pongo abelii OX=9601 GN=NGEF PE=2 SV=... [more]
sp|Q5VV41|ARHGG_HUMAN7.964e-4336.81Rho guanine nucleotide exchange factor 16 OS=Homo ... [more]
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BLAST of Guanine nucleotide exchange factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3EIW96.503e-7037.80Uncharacterized protein OS=Mesocestoides corti OX=... [more]
A0A158QGG31.978e-6939.18DH domain-containing protein OS=Rodentolepis nana ... [more]
A0A4S2LIW83.634e-6939.27DH domain-containing protein OS=Opisthorchis felin... [more]
A0A158QDA18.964e-6937.53DH domain-containing protein OS=Hymenolepis diminu... [more]
A0A564YL123.796e-6837.75DH domain-containing protein OS=Hymenolepis diminu... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
si:dkey-38p12.39.852e-4437.19rho guanine nucleotide exchange factor 15-like [So... [more]
arhgef165.491e-4135.02rho guanine nucleotide exchange factor 16 [Source:... [more]
arhgef165.491e-4135.02rho guanine nucleotide exchange factor 16 [Source:... [more]
ARHGEF261.959e-3834.74Rho guanine nucleotide exchange factor 26 [Source:... [more]
ARHGEF262.544e-3634.81Rho guanine nucleotide exchange factor 26 [Source:... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000000490.11.963e-3530.99pep scaffold:Pmarinus_7.0:GL477825:44699:67115:1 g... [more]
ENSPMAT00000007206.11.586e-1633.71pep scaffold:Pmarinus_7.0:GL501079:1421:14838:1 ge... [more]
ENSPMAT00000009516.18.545e-1128.35pep scaffold:Pmarinus_7.0:GL478064:31675:37139:1 g... [more]
ENSPMAT00000000080.15.290e-622.30pep scaffold:Pmarinus_7.0:GL476403:365803:389077:1... [more]
net15.405e-624.06neuroepithelial cell transforming 1 [Source:ZFIN;A... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ROM16.719e-627.53Guanine nucleotide exchange factor (GEF) for Rho1p... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO395952.139e-4135.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO396089.718e-825.64Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Guanine nucleotide exchange factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
arhgef161.903e-4435.89rho guanine nucleotide exchange factor 16 [Source:... [more]
arhgef161.903e-4435.89rho guanine nucleotide exchange factor 16 [Source:... [more]
ngef2.025e-4238.05neuronal guanine nucleotide exchange factor [Sourc... [more]
si:dkey-38p12.31.050e-3934.18ephexin-1 [Source:NCBI gene;Acc:101161585][more]
ngef5.770e-3936.56neuronal guanine nucleotide exchange factor [Sourc... [more]
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BLAST of Guanine nucleotide exchange factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000056271.10.000e+095.13SMESG000056271.1[more]
SMESG000056271.10.000e+094.60SMESG000056271.1[more]
SMESG000056271.10.000e+099.37SMESG000056271.1[more]
SMESG000044434.14.004e-6841.18SMESG000044434.1[more]
SMESG000003812.11.042e-2730.72SMESG000003812.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30021016 ID=SMED30021016|Name=Guanine nucleotide exchange factor|organism=Schmidtea mediterranea sexual|type=transcript|length=4186bp
GAAAGTCTTCACGAACATTAGAAACTAAATTTCCATATGAATCGATAGAA
AGAAAATTCCATTACAGCATGTATATATACGACATGAGGAGAAGAAATAG
AACACAGGCTTTCTGTCGGCAGCTCATTGGACACATGGATCTCCAGTCAA
TTATACCACCCACTCAGATACTGTTCCAGCATTTTTATGGGGTTGTCTAG
GTAACAACCATTTAGTTTCTAAATTTTTACCAGCCAGAATTCCACAAACA
TAATATAATGCATTTGTTATTTTTAGATCTTCCAAGTTCTGACTTCCATT
TATTCAGATTAGCGCGGTTGATTTTCTTTCTGGTTTCTCAATATGTTTAT
TTCTGAGTGATATATATTAATTAATTATTCCCAGTGGCCAGCTAGCAATC
GATTCGTGCTCTGGTGTCGGACTTTAGTGAGAAAGGAATCTGGGCCGCAG
AATTTCCGTTTCACCGATGCCCCTCTTCCAAGTCACTGAAATAAGTCCAG
TTGGTCAAGAATCAATTTATTTGCTTTTTTCTCTTGGAAATTCAAATTCA
ACAAAAACAATCTTCAGAAATGATGCGAGAAATCGAAAAGTTATTCGAAT
CATTAAAAGACGATTTTAACGAAAAACTTTCAAATATTAGCTATTTTACA
AACTTTAATGCTCCGATTGAAAATCATGTCGTAAATGCCGGTGGTTCAAT
TTCAGATAGCTTTGAAGATATTTCATTGTGTGGGGATGTTGCACAAGTAG
AGCCCATGAAGTCAAAGATTATTTTATTTGTTGATAGTGATACTGAATAT
TTACCAATAACAAATTACAATAGCGAGAACATTAATGGAACTTTTTTAAT
TGAAAAATCAAGATATACAGAAATAATTTTTGACAACTCTCCAGATCCTA
CAGTAACTGACGCTGAAAACCTTTTGAGGAAATCCAAATTGAATAATAAT
AATAATAATTCACAACTCTCAGAGGGGGATTCTGACGTAGAAACTTGTCA
ACAGGCTGATAGCATATCTGATACTATAGACAATGAAAAGTATTCTGAAA
AGTATTTACATTATAAATTAGAAAATGCTGAAAATTTCGAAATCCACTAT
AGAACGGCCAAAGAAAGTTTATCATTTATAAATACAGTGACCAATGCAGA
CATTGAAATAGGAAAATTGGTGGTCCCTGTTAATAAGCATTTTTCGGATT
TCAACAAGAATAATAATGCTTTAGATGACAATTTCAATCTTAAAAAAGAT
GATATAGTCGAAGAGTATGAGGAAATCAGTGACAATGAAATAAATCAATC
AATATATGACGAAAGTAAAGAGCAAGATAAAACTTCAGAAGAAAAATCCA
AAATAAATGAAAATGTTAATAGTGCAGAAATACTTAATGAAAGCGATCCG
ATTCAAATAGTCATAATACCGGATCAGAAACCGGGTAATAAAAAACCTAA
AGAAATAAGTATTAAGGAAAAAGAACCATTAAATGAGATTAATAATAATA
ATAATCAATTTATAGAAACTGTCTCATATGTAAAAGGTATAGATGATATA
AACCAGACCATTCAGGAAACATTTCCCATCTATGGTAAGAGAGGTTCTAA
AAACTCAGAAAATGATCCACAAGTGAATCACCGGGAATCAATAAGGGTGA
GAAAGACATCTAGCTTGAATTATAGCCGAAATCAGAGGATGTGGTCCGAT
ATGCCCGAGGTAAATGAGTCTGGAATTTTGAAAGTTTTATCTAAAAACGA
AATACAACTTCAAGAGGCTATGTTCGAAATTATAACATCTGAAGCTTCAT
ATTATCGAAGTCTGATGATTTTAACGAAACATTTTTTCTCGTCGGAACTA
TTCTCCATATCCGAGGACAAAGAAACGATAGTTTCACCAATAGATAAGCA
TCATATATTTTCCAATGTCATTCTAATTATGAAAACTAGTTTGAATTTAC
TGAATGATCTAGAACAAAGGTGGCACGAAGAAAAACCGGTGATGTCGGAT
ATTTGTGATATAGTTTTGAATCATGTTATTAGTGACGATTTCCAGAGTTA
TGTAACCTATTTACGAAATCAGCAATACCAGACCCAAGCTCTCAAGCGTT
TGTCTGAAAACGAGTATTTTAAACAACAGTTGTCTAAACTTGAATCATCT
AGTGAATGTGGAAAGTTGTCTTTGGACAGTTATTTAATGTTGCCTATGCA
AAGATTAACACGACTGAAATTACTTGTTGAAGCAGTTTCAAAATTTCAAA
ATATTGAAGGTATAACCAATGAAATAAGTGAATCTGTAAAAAACAATGCA
TTTATTGCACTGGATAAAATTAAAACGCTTTTGAATACAAGCAATACAGA
AAAAGGATTTATGGATCAGAAGAGTGCATTAATTTCTTTAATTAATAGAA
TCTATTTTCCGCCGAATGTTAAGAGTATCACTTTTAGTGATAGAATTCTT
TTACGCGAAGAAGAATTGCGAGTCCATCCGTACACTGGAATAAAAACTAT
TAGAAAAATCAGCAAAAAAAAACAGCCGCTAATAGTCCTTGTTCTTTTCA
ATGATTTACTAATAATCACAAAAAAGAAAAGTGGCAGATTACTCGTTTTG
GACTATTCTAATAAAGCAAATGTTACAATAGAAACTTCATCGTTTAAAAG
AAATATATCCAGCACTGAAATTTCTAGAAATACAAGTTCGTTTGATGTCA
ATTCCGAGTCCCAATCTCCTATCAGAATTATTGGAACTACTTTGATGAGA
AGTAAAACGTCGTTAACGGGAGACGAAAGGAAAAGACTCTCAGTACCATT
GAACAATTCCTTCACATCCATGCCTCAAATTAATAAAACAGAAGTTCACG
AATTCAAGCATCAAACATTTACTATGAAATTAATGAAAAGTGATATTTTT
CCCGATTCTCTTTATTTAACTACTCGCAGCAGAGAAGATCGAGATTTGTG
GTTATCATTCTTCGATAAAGATAATCCAGAAGATCAGATTGATTCATCAT
TTAAAAATTTTTCAAGATTGCAAAAGACAACGTCCTTGAAAATTAAACCA
AACCACTCTGAGATACCACGTTCAATTCTAAAAGTTCAATCCTTTCAAAC
AACGGATGATGGAATTACTGATGAAATATTAGCTCAATCTGAAATTGCTC
AAGATTGGAGCGATGAGTTCCTCATGGTAAGAACCAATGAAATGGGTTAT
ATACTCAGCTTAAGGGAGAGGGATGTTTTCTCATTTTCATTTTTTTCCTA
AATATTTTGCTAACATTTATTATTTTATGATTTTCTAACAGTGCATTCTC
ACTTTCTAAAATATTTCATTAATGTTTGGATAAGTTGTTAATTAACAATG
TCAGAGGTCTATGTTTGTGGTTACTGTAATGTGTCTTCTCGTTGACTGAT
TTCAAACCGTGACATTCGACCCGGTCAAGCACGAGTGCTCACCTACATAC
TCACCGTTATGTAATATTTGTTAATTAGAAATTTTTATGAGATTTTTTGT
CACCTTAAGTTTCGGTTTCACTGACATTAATATGTTTTTATTTTTTTTTG
AATAACAAATAGAAATATCACGAAACAATTGTATATATTTTTTCTTAAAA
AAAATGTATTAATGAACAAATTTACTGAAATGTTTTTGCCCGCCTACCGG
ACACTATATAAAGAATAATTTAAACGCTTAGGACTAGCTATATAGATTTT
GATTTAAATTAGGCATCAGCTTGTACTCAAATCGGACTTCAAATTCACTA
TTTTTCACAATATATATTATATAAACCAAACTTCAAATAAAATTCAATAA
TGTATCTTCAAATTCTGAGTGATGTCAAGCTACTGCAATCATACAATTGT
TTTATTTATTTCACATTAATGATTTTAGTTAGCTTTTAATTGCAATGAAA
ACTTTATATTTATAAAAAAAATATTTAATCACACCATATTAAAGCACTTT
TTCCAAGTAAATAAGTGAGACGAAAGACAAAGGAACCCGTCTCTGTCTCT
AATGATCCTACTCTTCATATATTTAAAAATTTTGATATGAAAGATCAAAT
TGAATATCCTTTTTTATCAAATGTATGCAATTTTACTATTATATTTGTTT
TGATTTTATATGCTCAAGATCGTTTATACAATCAGTAACAACATGTATCC
TTTTCTTATTCGTCTTTATCTGTTTTTGTTTACGAG
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protein sequence of SMED30021016-orf-1

>SMED30021016-orf-1 ID=SMED30021016-orf-1|Name=SMED30021016-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=894bp
MMREIEKLFESLKDDFNEKLSNISYFTNFNAPIENHVVNAGGSISDSFED
ISLCGDVAQVEPMKSKIILFVDSDTEYLPITNYNSENINGTFLIEKSRYT
EIIFDNSPDPTVTDAENLLRKSKLNNNNNNSQLSEGDSDVETCQQADSIS
DTIDNEKYSEKYLHYKLENAENFEIHYRTAKESLSFINTVTNADIEIGKL
VVPVNKHFSDFNKNNNALDDNFNLKKDDIVEEYEEISDNEINQSIYDESK
EQDKTSEEKSKINENVNSAEILNESDPIQIVIIPDQKPGNKKPKEISIKE
KEPLNEINNNNNQFIETVSYVKGIDDINQTIQETFPIYGKRGSKNSENDP
QVNHRESIRVRKTSSLNYSRNQRMWSDMPEVNESGILKVLSKNEIQLQEA
MFEIITSEASYYRSLMILTKHFFSSELFSISEDKETIVSPIDKHHIFSNV
ILIMKTSLNLLNDLEQRWHEEKPVMSDICDIVLNHVISDDFQSYVTYLRN
QQYQTQALKRLSENEYFKQQLSKLESSSECGKLSLDSYLMLPMQRLTRLK
LLVEAVSKFQNIEGITNEISESVKNNAFIALDKIKTLLNTSNTEKGFMDQ
KSALISLINRIYFPPNVKSITFSDRILLREEELRVHPYTGIKTIRKISKK
KQPLIVLVLFNDLLIITKKKSGRLLVLDYSNKANVTIETSSFKRNISSTE
ISRNTSSFDVNSESQSPIRIIGTTLMRSKTSLTGDERKRLSVPLNNSFTS
MPQINKTEVHEFKHQTFTMKLMKSDIFPDSLYLTTRSREDRDLWLSFFDK
DNPEDQIDSSFKNFSRLQKTTSLKIKPNHSEIPRSILKVQSFQTTDDGIT
DEILAQSEIAQDWSDEFLMVRTNEMGYILSLRERDVFSFSFFS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005089Rho guanyl-nucleotide exchange factor activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002032epidermal cell
PLANA:0003117parapharyngeal cell
Vocabulary: INTERPRO
TermDefinition
IPR035899DBL_dom_sf
IPR000219DH-domain
Vocabulary: biological process
TermDefinition
GO:0035023regulation of Rho protein signal transduction
GO:0043547positive regulation of GTPase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000219Dbl homology (DH) domainSMARTSM00325RhoGEF_3coord: 400..593
e-value: 4.5E-23
score: 92.6
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 401..560
e-value: 3.4E-26
score: 92.6
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 396..594
score: 23.107
IPR000219Dbl homology (DH) domainCDDcd00160RhoGEFcoord: 397..592
e-value: 9.24627E-26
score: 103.146
IPR035899Dbl homology (DH) domain superfamilyGENE3DG3DSA:1.20.900.10coord: 372..611
e-value: 1.5E-41
score: 144.5
IPR035899Dbl homology (DH) domain superfamilySUPERFAMILYSSF48065DBL homology domain (DH-domain)coord: 380..614
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 244..262
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 123..142
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 241..262
NoneNo IPR availablePANTHERPTHR12845GUANINE NUCLEOTIDE EXCHANGE FACTORcoord: 153..805