Aristaless-like homeobox transcription factor

Overview


Name	Aristaless-like homeobox transcription factor
Smed ID	SMED30020992
Length (bp)	1769

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Aristaless-like homeobox transcription factor (SMED30020992) t-SNE clustered cells

Violin plots show distribution of expression levels for Aristaless-like homeobox transcription factor (SMED30020992) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Aristaless-like homeobox transcription factor (SMED30020992) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30020992

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
central nervous system	SMED30020992	h1SMcG0007253	dd_Smed_v4_21801_0_1	dd_Smed_v4	PMID:27063937 Scimone et al., 2016
posterior region of the whole animal	SMED30020992	h1SMcG0007253	dd_Smed_v4_21801_0_1	dd_Smed_v4	PMID:27063937 Scimone et al., 2016
X2 cell	SMED30020992	h1SMcG0007253	SmedASXL_000870	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
prepharyngeal region	SMED30020992	h1SMcG0007253	dd_Smed_v6_21801_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
central nervous system	SMED30020992	h1SMcG0007253	KJ934810	smed_ncbi_20240424	PMID:25254346 Scimone et al., 2014
ventral nerve cord	SMED30020992	h1SMcG0007253	KX961610	smed_ncbi_20240424	PMID:27864883 Currie et al., 2016
neuron	SMED30020992	h1SMcG0007253	KX961610	smed_ncbi_20240424	PMID:27864883 Currie et al., 2016
cholinergic neuron	SMED30020992	h1SMcG0007253	KX961610	smed_ncbi_20240424	PMID:27864883 Currie et al., 2016
GABAergic neuron	SMED30020992	h1SMcG0007253	KX961610	smed_ncbi_20240424	PMID:27864883 Currie et al., 2016
octopaminergic neuron	SMED30020992	h1SMcG0007253	KX961610	smed_ncbi_20240424	PMID:27864883 Currie et al., 2016
reproductive organ	SMED30020992	h1SMcG0007253	Contig55206	newmark_ests	PMID:28434803 Rouhana et al., 2017
reproductive organ	SMED30020992	h1SMcG0007253	Contig55206	uc_Smed_v2	PMID:28434803 Rouhana et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Match: ALX1 (ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494])

HSP 1 Score: 102.064 bits (253), Expect = 3.868e-23
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Match: PROP1 (PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455])

HSP 1 Score: 99.3673 bits (246), Expect = 5.031e-23
Identity = 46/68 (67.65%), Postives = 56/68 (82.35%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            +RRRHRTTF+  QL++LESAF ++ YPDI+ RE LAR T L+EARIQVWFQNRRAK RKQE+ L + L
Sbjct:   68 SRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPL 135

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Match: PROP1 (PROP paired-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9455])

HSP 1 Score: 99.3673 bits (246), Expect = 5.539e-23
Identity = 46/68 (67.65%), Postives = 56/68 (82.35%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            +RRRHRTTF+  QL++LESAF ++ YPDI+ RE LAR T L+EARIQVWFQNRRAK RKQE+ L + L
Sbjct:   68 SRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPL 135

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Match: ALX4 (ALX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:450])

HSP 1 Score: 101.293 bits (251), Expect = 2.474e-22
Identity = 42/61 (68.85%), Postives = 52/61 (85.25%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR+RTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T L EAR+QVWFQNRRAK+RK+E+
Sbjct:  214 KRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRER 274

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Match: ALX3 (ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449])

HSP 1 Score: 96.6709 bits (239), Expect = 2.769e-22
Identity = 41/61 (67.21%), Postives = 52/61 (85.25%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR+RTTF+  QL+ELE  FQK+HYPD+Y RE+LA  T L EAR+QVWFQNRRAK+RK+E+
Sbjct:   10 KRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER 70

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9769361:-1 gene:WBGene00006778.1 transcript:F58E6.10a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 144.821 bits (364), Expect = 3.856e-39
Identity = 70/92 (76.09%), Postives = 78/92 (84.78%), Query Frame = 2

Query:  971 TPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP--SLPS--CNTAIMRSMYPS 1234
            TPARRRHRTTFTQEQLQEL++AFQKSHYPDIY REELARITKLNEARIQVWFQNRRAK+RK EKQL K ++P  S  S   NT + + MYP+
Sbjct:   82 TPARRRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQLNKAINPPHSFLSNPANTLMRQGMYPA 173

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9767679:-1 gene:WBGene00006778.1 transcript:F58E6.10d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 142.895 bits (359), Expect = 4.793e-39
Identity = 70/92 (76.09%), Postives = 78/92 (84.78%), Query Frame = 2

Query:  971 TPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP--SLPS--CNTAIMRSMYPS 1234
            TPARRRHRTTFTQEQLQEL++AFQKSHYPDIY REELARITKLNEARIQVWFQNRRAK+RK EKQL K ++P  S  S   NT + + MYP+
Sbjct:   31 TPARRRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQLNKAINPPHSFLSNPANTLMRQGMYPA 122

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9769361:-1 gene:WBGene00006778.1 transcript:F58E6.10b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 137.887 bits (346), Expect = 1.616e-36
Identity = 67/90 (74.44%), Postives = 76/90 (84.44%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP--SLPS--CNTAIMRSMYPS 1234
            +RRRHRTTFTQEQLQEL++AFQKSHYPDIY REELARITKLNEARIQVWFQNRRAK+RK EKQL K ++P  S  S   NT + + MYP+
Sbjct:   99 SRRRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQLNKAINPPHSFLSNPANTLMRQGMYPA 188

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9767679:-1 gene:WBGene00006778.1 transcript:F58E6.10e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 135.961 bits (341), Expect = 2.350e-36
Identity = 67/90 (74.44%), Postives = 76/90 (84.44%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP--SLPS--CNTAIMRSMYPS 1234
            +RRRHRTTFTQEQLQEL++AFQKSHYPDIY REELARITKLNEARIQVWFQNRRAK+RK EKQL K ++P  S  S   NT + + MYP+
Sbjct:   48 SRRRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQLNKAINPPHSFLSNPANTLMRQGMYPA 137

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Match: ceh-10 (Homeobox protein ceh-10 [Source:UniProtKB/Swiss-Prot;Acc:P41935])

HSP 1 Score: 99.3673 bits (246), Expect = 1.656e-22
Identity = 46/65 (70.77%), Postives = 50/65 (76.92%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTK 1174
            +RRHRT FTQ Q+ ELE AFQ SHYPDIY RE LA  T+L E RIQVWFQNRRAK+RK EK   K
Sbjct:  136 KRRHRTIFTQYQIDELEKAFQDSHYPDIYAREVLAGKTELQEDRIQVWFQNRRAKWRKTEKTWGK 200

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BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Match: CG32532 (gene:FBgn0052532 transcript:FBtr0340418)

HSP 1 Score: 167.933 bits (424), Expect = 1.490e-46
Identity = 79/98 (80.61%), Postives = 84/98 (85.71%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSM 1225
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS +PSCN  +MR++
Sbjct:  165 HAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCN-GMMRNI 261

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Match: CG32532 (gene:FBgn0052532 transcript:FBtr0340419)

HSP 1 Score: 167.933 bits (424), Expect = 1.744e-46
Identity = 79/98 (80.61%), Postives = 84/98 (85.71%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSM 1225
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS +PSCN  +MR++
Sbjct:  165 HAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCN-GMMRNI 261

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Match: CG32532 (gene:FBgn0052532 transcript:FBtr0340420)

HSP 1 Score: 169.859 bits (429), Expect = 7.501e-45
Identity = 79/98 (80.61%), Postives = 84/98 (85.71%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSM 1225
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS +PSCN  +MR++
Sbjct:  495 HAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCN-GMMRNI 591

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Match: Pph13 (gene:FBgn0023489 transcript:FBtr0078070)

HSP 1 Score: 101.679 bits (252), Expect = 4.346e-23
Identity = 43/61 (70.49%), Postives = 51/61 (83.61%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR+RTTF   QLQELE AFQ++HYPD++ REELA    L EAR+QVWFQNRRAK+RKQEK
Sbjct:   10 QRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQEK 70

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Match: al (gene:FBgn0000061 transcript:FBtr0078053)

HSP 1 Score: 102.449 bits (254), Expect = 4.601e-23
Identity = 47/74 (63.51%), Postives = 56/74 (75.68%), Query Frame = 2

Query:  965 CPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP 1186
             P   +RR+RTTFT  QL+ELE AF ++HYPD++ REELA    L EARIQVWFQNRRAK+RKQEK +  Q HP
Sbjct:   80 APKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEK-VGPQSHP 152

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Zebrafish
Match: prop1 (PROP paired-like homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-081107-40])

HSP 1 Score: 115.546 bits (288), Expect = 6.816e-29
Identity = 54/86 (62.79%), Postives = 67/86 (77.91%), Query Frame = 2

Query:  968 PTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSM 1225
            P+P+RRRHRTTF+ EQL+ LE AF+++HYPDIY REELAR+TKLNEARIQVWFQNRRAK RKQ++   K L  S+      +  +M
Sbjct:   52 PSPSRRRHRTTFSNEQLEHLELAFRQNHYPDIYYREELARVTKLNEARIQVWFQNRRAKQRKQDRITQKSLAVSMMPVRGPLFSTM 137

[Close]

Query:  968 PTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSM 1225
            P+P+RRRHRTTF+ EQL+ LE AF+++HYPDIY REELAR+TKLNEARIQVWFQNRRAK RKQ++   K L  S+      +  +M
Sbjct:   52 PSPSRRRHRTTFSNEQLEHLELAFRQNHYPDIYYREELARVTKLNEARIQVWFQNRRAKQRKQDRITQKSLAVSMMPVRGPLFSTM 137

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Zebrafish
Match: prop1 (PROP paired-like homeobox 1 [Source:ZFIN;Acc:ZDB-GENE-081107-40])

HSP 1 Score: 115.546 bits (288), Expect = 8.210e-29
Identity = 54/86 (62.79%), Postives = 67/86 (77.91%), Query Frame = 2

Query:  968 PTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSM 1225
            P+P+RRRHRTTF+ EQL+ LE AF+++HYPDIY REELAR+TKLNEARIQVWFQNRRAK RKQ++   K L  S+      +  +M
Sbjct:   52 PSPSRRRHRTTFSNEQLEHLELAFRQNHYPDIYYREELARVTKLNEARIQVWFQNRRAKQRKQDRITQKSLAVSMMPVRGPLFSTM 137

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Zebrafish
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:565176])

HSP 1 Score: 103.605 bits (257), Expect = 6.964e-24
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  120 KRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRER 180

[Close]

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  120 KRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRER 180

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Match: ENSXETT00000043226.1 (PROP paired-like homeobox 1 [Source:NCBI gene;Acc:101734397])

HSP 1 Score: 107.457 bits (267), Expect = 9.822e-26
Identity = 52/80 (65.00%), Postives = 63/80 (78.75%), Query Frame = 2

Query: 1001 FTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHP-SLPSCNTAI--MRSMYP 1231
            F+QEQL+ LE+AF K+HYPDIYCREELA+ITKLNEARIQVWFQNRRAK+RK E+   K   P S+ +C + +  M SM P
Sbjct:   73 FSQEQLEHLETAFSKNHYPDIYCREELAKITKLNEARIQVWFQNRRAKHRKHERTTQKSTVPSSMLTCGSLMSGMCSMSP 152

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Match: ALX1 (ALX homeobox 1 [Source:NCBI gene;Acc:100489661])

HSP 1 Score: 102.449 bits (254), Expect = 2.769e-23
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Match: ENSXETT00000045443.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:8:38234864:38239775:1 gene:ENSXETG00000019174.1 transcript:ENSXETT00000045443.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 97.4413 bits (241), Expect = 8.693e-23
Identity = 44/70 (62.86%), Postives = 56/70 (80.00%), Query Frame = 2

Query:  959 NSCPTPAR--RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +S P+  R  RR+RTTF+  QL+ELE AF+KSHYPD++ RE+LA    L EAR+QVWFQNRRAK+RK+EK
Sbjct:    7 SSAPSGKRKQRRYRTTFSNLQLEELEMAFRKSHYPDVFTREDLAMRLDLTEARVQVWFQNRRAKWRKREK 76

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Match: ARX (aristaless related homeobox [Source:NCBI gene;Acc:100486727])

HSP 1 Score: 103.605 bits (257), Expect = 8.699e-23
Identity = 46/71 (64.79%), Postives = 55/71 (77.46%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLP 1195
            RR+RTTFT  QL+ELE AFQK+HYPD++ REELA    L EAR+QVWFQNRRAK+RK+EK   +   P LP
Sbjct:  302 RRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHAPGLP 372

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Match: PAX7 (paired box 7 [Source:NCBI gene;Acc:100496502])

HSP 1 Score: 102.449 bits (254), Expect = 8.741e-23
Identity = 43/59 (72.88%), Postives = 52/59 (88.14%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQ 1156
            +RR RTTFT EQL+ELE AF+++HYPDIY REELA+ TKL EAR+QVWF NRRA++RKQ
Sbjct:  119 QRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ 177

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Mouse
Match: Alx1 (ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621])

HSP 1 Score: 101.293 bits (251), Expect = 1.467e-23
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Mouse
Match: Alx1 (ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621])

HSP 1 Score: 102.449 bits (254), Expect = 2.486e-23
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Match: sp|Q1LVQ7|ALX1_DANRE (ALX homeobox protein 1 OS=Danio rerio OX=7955 GN=alx1 PE=2 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 5.257e-23
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  120 KRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRER 180

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Match: sp|Q3LU40|PROP1_SAPAP (Homeobox protein prophet of Pit-1 OS=Sapajus apella OX=9515 GN=PROP1 PE=3 SV=1)

HSP 1 Score: 100.523 bits (249), Expect = 1.107e-22
Identity = 46/68 (67.65%), Postives = 56/68 (82.35%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            +RRRHRTTF+  QL++LESAF ++ YPDI+ RE LAR T L+EARIQVWFQNRRAK RKQE+ L + L
Sbjct:   68 SRRRHRTTFSAVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPL 135

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Match: sp|Q91574|ALX1_XENLA (ALX homeobox protein 1 OS=Xenopus laevis OX=8355 GN=alx1 PE=2 SV=1)

HSP 1 Score: 102.449 bits (254), Expect = 1.570e-22
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  141 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 201

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Match: sp|Q9GLL9|PROP1_PIG (Homeobox protein prophet of Pit-1 OS=Sus scrofa OX=9823 GN=PROP1 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.676e-22
Identity = 46/68 (67.65%), Postives = 56/68 (82.35%), Query Frame = 2

Query:  977 ARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            +RRRHRTTF+  QL++LESAF ++ YPDI+ RE LAR T L+EARIQVWFQNRRAK RKQE+ L + L
Sbjct:   68 SRRRHRTTFSPAQLEQLESAFGRNQYPDIWAREGLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPL 135

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Match: sp|Q63087|ALX1_RAT (ALX homeobox protein 1 OS=Rattus norvegicus OX=10116 GN=Alx1 PE=1 SV=1)

HSP 1 Score: 102.449 bits (254), Expect = 1.690e-22
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  132 KRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRER 192

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Match: A0A1L2TQQ2 (Aristaless-like homeobox transcription factor OS=Schmidtea mediterranea OX=79327 GN=arx PE=2 SV=1)

HSP 1 Score: 744.191 bits (1920), Expect = 0.000e+0
Identity = 472/474 (99.58%), Postives = 472/474 (99.58%), Query Frame = 2

Query:  236 MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFXXXXXXXXXXXXXXXXXXXXXXXXQNSSGPINASSASNQVSISANTVHSQSTNINQSEKPIIDPXXXXXXXXXXXXXXXXXXXXXXXXXHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXTVAAARNYVQIPHAASNYNGLATSFGXXXXXXXXXXXXLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS 1657
            MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFSSNTGLNNNNNNNNNSTNKSSILNQNSSG INASSASNQVSISANTVHSQSTNINQSEKPIIDPLTSSSLSNTCISTSSCPTTISNNNSHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSGVCGVNTVNAVVGVGNRVPSSINGNNASAYSNYCSSTVAAARNYVQIPHAASNYNGLATSFGNMNSNHHTNNMTLPPIAGS VNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS
Sbjct:    1 MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFSSNTGLNNNNNNNNNSTNKSSILNQNSSGQINASSASNQVSISANTVHSQSTNINQSEKPIIDPLTSSSLSNTCISTSSCPTTISNNNSHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSGVCGVNTVNAVVGVGNRVPSSINGNNASAYSNYCSSTVAAARNYVQIPHAASNYNGLATSFGNMNSNHHTNNMTLPPIAGSTVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS 474

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Match: N6UEP6 (Homeobox domain-containing protein (Fragment) OS=Dendroctonus ponderosae OX=77166 GN=YQE_03349 PE=4 SV=1)

HSP 1 Score: 184.111 bits (466), Expect = 1.002e-50
Identity = 118/255 (46.27%), Postives = 136/255 (53.33%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSMYPSXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXTVAAARNYVQIPH----------AASNYNGLATSFGXXXXXXXXXXXXLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSAL--NGSHNA-LGNPILPYHS 1657
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS LP CN A+MR++YP                                        AAR Y   PH            S+Y G+A SF                        S+S H +N+    G +  Q+ MS+  S+E++WY  SLSAL  N SH+  L  P+L Y +
Sbjct:   36 HAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARSTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVLPGCNGAMMRNIYP---------------------------------------GAARGYQPYPHPTAINRYPQMTTSSYPGMAQSF------------------------SMS-HTTNMSSVAGMR--QDAMSM--SAEDEWYNKSLSALRMNSSHHPNLAAPMLQYQT 222

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Match: D2A067 (ALX homeobox protein 1-like Protein OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC007335 PE=4 SV=1)

HSP 1 Score: 182.185 bits (461), Expect = 9.908e-50
Identity = 117/255 (45.88%), Postives = 136/255 (53.33%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSMYPSXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXTVAAARNYVQIPH----------AASNYNGLATSFGXXXXXXXXXXXXLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSAL--NGSHNA-LGNPILPYHS 1657
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS LP CN A+MR++YP                                        AAR Y   PH            S+Y G+A SF                        S+S H +N+    G +  Q+ MS+  S+E++WY  SLSAL  N +H+  L  P+L Y +
Sbjct:   49 HTGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARSTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVLPGCNGAMMRNIYP---------------------------------------GAARGYQPYPHPTAINRYPQMTTSSYPGMAQSF------------------------SMS-HGTNMTTVAGMR--QDAMSM--SAEDEWYNKSLSALRMNTTHHPNLAAPMLQYQT 235

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Match: U4UTX9 (Homeobox domain-containing protein OS=Dendroctonus ponderosae OX=77166 GN=D910_00738 PE=4 SV=1)

HSP 1 Score: 176.022 bits (445), Expect = 1.619e-48
Identity = 82/101 (81.19%), Postives = 86/101 (85.15%), Query Frame = 2

Query:  935 HGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPS-LPSCNTAIMRSMYPS 1234
            H  H PT  SCPTPARRRHRTTFTQEQL ELE+AF KSHYPDIYCREELAR TKLNEARIQVWFQNRRAKYRKQEKQL K L PS LP CN A+MR++YP 
Sbjct:   36 HAGHTPTTASCPTPARRRHRTTFTQEQLAELEAAFAKSHYPDIYCREELARSTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVLPGCNGAMMRNIYPG 136

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Match: A0A1I8HK83 (Homeobox domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 177.563 bits (449), Expect = 2.050e-48
Identity = 82/97 (84.54%), Postives = 85/97 (87.63%), Query Frame = 2

Query:  938 GHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMY 1228
            G HNPT  SCPTPARRRHRTTFTQEQL ELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQL KQL P +  C + +MR MY
Sbjct:   42 GGHNPTATSCPTPARRRHRTTFTQEQLTELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLAKQLSPVMAPCGS-MMRGMY 137

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Match: ENSAMXT00000049958.1 (homeobox protein prophet of Pit-1-like [Source:NCBI gene;Acc:103032793])

HSP 1 Score: 112.849 bits (281), Expect = 4.434e-28
Identity = 51/69 (73.91%), Postives = 60/69 (86.96%), Query Frame = 2

Query:  956 VNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            V   P+P+RRRHRTTF+ EQL++LE AF+ +HYPDIY REELA+ TKLNEARIQVWFQNRRAK RKQE+
Sbjct:   46 VRPHPSPSRRRHRTTFSHEQLEQLELAFRHNHYPDIYYREELAQTTKLNEARIQVWFQNRRAKQRKQER 114

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:565176])

HSP 1 Score: 103.219 bits (256), Expect = 7.890e-24
Identity = 48/76 (63.16%), Postives = 58/76 (76.32%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNT 1207
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+    Q  P  P  NT
Sbjct:  117 KRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGHLQ-QPKGPYSNT 191

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Match: rx2 (retinal homeobox protein Rx2-like [Source:NCBI gene;Acc:103040507])

HSP 1 Score: 101.293 bits (251), Expect = 5.145e-23
Identity = 46/77 (59.74%), Postives = 53/77 (68.83%), Query Frame = 2

Query:  950 PTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            P     P    RR+RTTFT  QL ELE AF+KSHYPD+Y REELA    L E R+QVWFQNRRAK+R+QEK  T  +
Sbjct:  128 PPEEDQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKMDTSSM 204

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Match: alx4a (ALX homeobox 4 [Source:NCBI gene;Acc:103046081])

HSP 1 Score: 100.523 bits (249), Expect = 1.530e-22
Identity = 42/61 (68.85%), Postives = 52/61 (85.25%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR+RTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T L EAR+QVWFQNRRAK+RK+E+
Sbjct:  173 KRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER 233

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Match: pax7b (paired box protein Pax-7-like [Source:NCBI gene;Acc:103027808])

HSP 1 Score: 101.293 bits (251), Expect = 1.832e-22
Identity = 43/59 (72.88%), Postives = 52/59 (88.14%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQ 1156
            +RR RTTFT EQL+ELE AF+++HYPDIY REELA+ TKL EAR+QVWF NRRA++RKQ
Sbjct:  177 QRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ 235

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Match: dmbx1b (diencephalon/mesencephalon homeobox 1b [Source:NCBI gene;Acc:550288])

HSP 1 Score: 92.4337 bits (228), Expect = 1.192e-20
Identity = 40/68 (58.82%), Postives = 52/68 (76.47%), Query Frame = 2

Query:  974 PARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQ 1177
            P +RR RT FT +QL+ LE  FQK+HYPD+  RE LA  T L EAR+QVWF+NRRAK+RK+++ L K+
Sbjct:   41 PHQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKE 108

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010761.1 (pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-1 gene:ENSPMAG00000009746.1 transcript:ENSPMAT00000010761.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 74.7146 bits (182), Expect = 4.904e-17
Identity = 35/61 (57.38%), Postives = 44/61 (72.13%), Query Frame = 2

Query:  968 PTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYR 1150
            P   +RR RTTFT+ QL  LE+ F K+ YPDI+ REE+A    L E+R+QVWF+NRRAK R
Sbjct:    2 PNRKQRRERTTFTRAQLDVLEALFSKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 62

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011473.1 (pep scaffold:Pmarinus_7.0:GL476736:88393:88668:-1 gene:ENSPMAG00000010446.1 transcript:ENSPMAT00000011473.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.5362 bits (140), Expect = 3.779e-11
Identity = 28/57 (49.12%), Postives = 40/57 (70.18%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRK 1153
            +R RT FT EQL  L++ FQ S Y     R+ LAR  +L+EA++++WFQN+RAK +K
Sbjct:   19 KRPRTAFTPEQLSRLKAEFQASRYLSEARRQALARDLQLSEAQVKIWFQNKRAKLKK 75

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Match: otx5 (orthodenticle homolog 5 [Source:ZFIN;Acc:ZDB-GENE-030508-1])

HSP 1 Score: 60.4622 bits (145), Expect = 2.260e-10
Identity = 29/55 (52.73%), Postives = 38/55 (69.09%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAK 1144
            +RR RTTFT+ QL +LES F K+ YPDI+ REE+A    L E+R+Q+ F   R K
Sbjct:   38 QRRERTTFTRAQL-DLESLFSKTRYPDIFMREEVALKINLPESRVQINFPESRVK 91

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009847.1 (pep scaffold:Pmarinus_7.0:GL481168:3356:14379:1 gene:ENSPMAG00000008904.1 transcript:ENSPMAT00000009847.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 59.6918 bits (143), Expect = 3.487e-10
Identity = 32/64 (50.00%), Postives = 42/64 (65.62%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLT 1171
            RR  RTT   +QL+ L +AF  +  P  + RE+LA+ T LN   IQVWFQNRR+K R+  KQL+
Sbjct:   27 RRGPRTTIKAKQLETLRAAFAATPKPSRHVREQLAQETGLNMRVIQVWFQNRRSKERRM-KQLS 89

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264])

HSP 1 Score: 49.6766 bits (117), Expect = 9.549e-7
Identity = 26/84 (30.95%), Postives = 45/84 (53.57%), Query Frame = 2

Query:  959 NSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTA 1210
            N+  +  +R  RT    E L  L+  F+ +  P +  R++++ +  + E  +++WFQNRRAK RK++    K   PS  S + A
Sbjct:   70 NASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQHGSNKDTIPSSQSRDIA 153

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Yeast
Match: YOX1 (Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication [Source:SGD;Acc:S000004489])

HSP 1 Score: 48.1358 bits (113), Expect = 2.067e-6
Identity = 26/69 (37.68%), Postives = 40/69 (57.97%), Query Frame = 2

Query:  950 PTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQ 1156
            P +++ P  ARR+ R T +QE L  L++ F+K   P    R ELA    + E  +Q+WFQN+R   ++Q
Sbjct:  168 PKIDNAPL-ARRKRRRTSSQE-LSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQ 234

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Match: EDO38926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH9])

HSP 1 Score: 97.8265 bits (242), Expect = 1.214e-23
Identity = 42/68 (61.76%), Postives = 54/68 (79.41%), Query Frame = 2

Query:  959 NSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +S P   +RR+RTTFT  QL+E+E  FQK+HYPD+Y RE+LA    L EAR+QVWFQNRRAK+RK+E+
Sbjct:    7 DSAPKRKKRRNRTTFTAYQLEEMERVFQKTHYPDVYTREQLALRCALTEARVQVWFQNRRAKWRKRER 74

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Match: EDO43002 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZT3])

HSP 1 Score: 90.1225 bits (222), Expect = 2.502e-22
Identity = 40/61 (65.57%), Postives = 51/61 (83.61%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTF++ QL  LE AF +S YPD++ RE+LA+   LNEAR+QVWFQNRRAK+RKQE+
Sbjct:    1 KRRHRTTFSKLQLDSLEEAFSRSQYPDVFTREQLAKRINLNEARVQVWFQNRRAKHRKQER 61

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Match: EDO42103 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2G7])

HSP 1 Score: 93.5893 bits (231), Expect = 6.993e-22
Identity = 41/65 (63.08%), Postives = 52/65 (80.00%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQ 1177
            RR RTTFT  QL +LE AF+K+ YPD++ REELA    L+EAR+QVWFQNRRAK+RK+EK L ++
Sbjct:   21 RRSRTTFTTYQLHQLERAFEKTQYPDVFTREELALRLDLSEARVQVWFQNRRAKWRKREKALGRE 85

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Match: EDO42147 (Predicted protein; Retinal homeobox [Source:UniProtKB/TrEMBL;Acc:A7S2G8])

HSP 1 Score: 94.3597 bits (233), Expect = 1.088e-21
Identity = 45/72 (62.50%), Postives = 53/72 (73.61%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPS 1198
            RR+RTTFT  QL ELE AF+KSHYPD+Y REELA    L E R+QVWFQN+RAK+R++EK     L   LPS
Sbjct:   86 RRNRTTFTTFQLHELERAFEKSHYPDVYTREELALKISLPEVRVQVWFQNKRAKWRREEKMEMASLQ-DLPS 156

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Match: EDO39160 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAY2])

HSP 1 Score: 89.7373 bits (221), Expect = 1.128e-21
Identity = 41/61 (67.21%), Postives = 49/61 (80.33%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRT FT  QL+ELE AF++SHYPD+Y RE L+    L E RIQVWFQNRRAK+RK+EK
Sbjct:    5 KRRHRTIFTNYQLEELEKAFKESHYPDVYARENLSLKIDLPEDRIQVWFQNRRAKWRKKEK 65

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Match: ENSORLT00000001768.2 (homeobox protein prophet of Pit-1-like [Source:NCBI gene;Acc:101168730])

HSP 1 Score: 121.709 bits (304), Expect = 3.790e-31
Identity = 56/87 (64.37%), Postives = 68/87 (78.16%), Query Frame = 2

Query:  968 PTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMY 1228
            P+PARRRHRTTF+ +QL++LE AF ++ YPDIYCREELARITKLNEARIQVWFQNRRAK RKQE+   K L   + S    ++  M+
Sbjct:   59 PSPARRRHRTTFSHKQLEQLERAFGQNQYPDIYCREELARITKLNEARIQVWFQNRRAKQRKQERASRKVLRGGVVSGPRGLLGGMH 145

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Match: alx1 (ALX homeobox 1 [Source:NCBI gene;Acc:101154901])

HSP 1 Score: 103.99 bits (258), Expect = 5.415e-24
Identity = 43/61 (70.49%), Postives = 53/61 (86.89%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RRHRTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T+L EAR+QVWFQNRRAK+RK+E+
Sbjct:  124 KRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRER 184

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Match: pax7 (paired box 7 [Source:NCBI gene;Acc:101174017])

HSP 1 Score: 101.679 bits (252), Expect = 1.420e-22
Identity = 43/59 (72.88%), Postives = 52/59 (88.14%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQ 1156
            +RR RTTFT EQL+ELE AF+++HYPDIY REELA+ TKL EAR+QVWF NRRA++RKQ
Sbjct:  178 QRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQ 236

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Match: rx2 (Rx2 transcription factor [Source:NCBI gene;Acc:100125458])

HSP 1 Score: 99.3673 bits (246), Expect = 1.690e-22
Identity = 44/66 (66.67%), Postives = 51/66 (77.27%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQL 1180
            RR+RTTFT  QL ELE AF+KSHYPD+Y REELA    L E R+QVWFQNRRAK+R+QEK  T  +
Sbjct:  138 RRNRTTFTTYQLHELERAFEKSHYPDVYSREELATKVNLPEVRVQVWFQNRRAKWRRQEKMDTSTM 203

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Match: alx4b (homeobox protein aristaless-like 4 [Source:NCBI gene;Acc:101168948])

HSP 1 Score: 100.138 bits (248), Expect = 1.856e-22
Identity = 42/61 (68.85%), Postives = 52/61 (85.25%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR+RTTFT  QL+ELE  FQK+HYPD+Y RE+LA  T L EAR+QVWFQNRRAK+RK+E+
Sbjct:  173 KRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER 233

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Match: SMESG000030143.1 (SMESG000030143.1)

HSP 1 Score: 746.888 bits (1927), Expect = 0.000e+0
Identity = 473/474 (99.79%), Postives = 474/474 (100.00%), Query Frame = 2

Query:  236 MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFXXXXXXXXXXXXXXXXXXXXXXXXQNSSGPINASSASNQVSISANTVHSQSTNINQSEKPIIDPXXXXXXXXXXXXXXXXXXXXXXXXXHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSXXXXXXXXXXXXXXXXXXPXXXXXXXXXXXXXXXXXTVAAARNYVQIPHAASNYNGLATSFGXXXXXXXXXXXXLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS 1657
            MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFSSNTGLNNNNNNNNNSTNKSSILNQNSSGPINASSASNQVSISANTVHSQSTNINQSEKPIIDPLTSSSLSNTCISTSSCPTTISNNNSHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSGVCGVNTVNAVVGVGNRVPSSINGNNASAYSNYCSSTVAAARNYVQIPHAASNYNGLA+SFGNMNSNHHTNNMTLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS
Sbjct:    1 MTEAGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSHLSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSFKKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFSSNTGLNNNNNNNNNSTNKSSILNQNSSGPINASSASNQVSISANTVHSQSTNINQSEKPIIDPLTSSSLSNTCISTSSCPTTISNNNSHGHHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQLTKQLHPSLPSCNTAIMRSMYPSGVCGVNTVNAVVGVGNRVPSSINGNNASAYSNYCSSTVAAARNYVQIPHAASNYNGLASSFGNMNSNHHTNNMTLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKASLSALNGSHNALGNPILPYHS 474

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Match: SMESG000033843.1 (SMESG000033843.1)

HSP 1 Score: 100.138 bits (248), Expect = 2.904e-23
Identity = 48/88 (54.55%), Postives = 59/88 (67.05%), Query Frame = 2

Query:  983 RRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK----QLTKQLHPSLPSCNTAIMRSMYPS 1234
            RR+RTTFT  QL ELE AF+KSHYPD+Y REELA    L E R+QVWFQNRRAK+R+QEK      T  L    P+   ++   ++PS
Sbjct:   91 RRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKISLPEVRVQVWFQNRRAKWRRQEKIEAANHTHNLQEVFPNVGKSLTSGLFPS 178

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Match: SMESG000052478.1 (SMESG000052478.1)

HSP 1 Score: 98.9821 bits (245), Expect = 3.986e-22
Identity = 42/61 (68.85%), Postives = 50/61 (81.97%), Query Frame = 2

Query:  980 RRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            +RR RTTFT  QL+ELE +FQ++HYPDIY REE+A    L EAR+QVWFQNRRAK+RK EK
Sbjct:  226 QRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKMEK 286

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 98.5969 bits (244), Expect = 4.824e-22
Identity = 43/74 (58.11%), Postives = 56/74 (75.68%), Query Frame = 2

Query:  941 HHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            HH+   +      +RR+RTTFT +QL+ELE AFQ++HYPD++ REELA    L EAR+QVWFQNRRAK+RK E+
Sbjct:   24 HHDLADDIFSRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTER 97

[Close]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 98.2117 bits (243), Expect = 5.642e-22
Identity = 43/74 (58.11%), Postives = 56/74 (75.68%), Query Frame = 2

Query:  941 HHNPTVNSCPTPARRRHRTTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEK 1162
            HH+   +      +RR+RTTFT +QL+ELE AFQ++HYPD++ REELA    L EAR+QVWFQNRRAK+RK E+
Sbjct:   17 HHDLADDIFSRRKQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTER 90

The following BLAST results are available for this feature:

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Zebrafish
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Mouse
BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Yeast
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ALX1	3.868e-23	70.49	ALX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:1494]	[more]
PROP1	5.031e-23	67.65	PROP paired-like homeobox 1 [Source:HGNC Symbol;Ac...	[more]
PROP1	5.539e-23	67.65	PROP paired-like homeobox 1 [Source:HGNC Symbol;Ac...	[more]
ALX4	2.474e-22	68.85	ALX homeobox 4 [Source:HGNC Symbol;Acc:HGNC:450]	[more]
ALX3	2.769e-22	67.21	ALX homeobox 3 [Source:HGNC Symbol;Acc:HGNC:449]	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
unc-42	3.856e-39	76.09	pep chromosome:WBcel235:V:9764645:9769361:-1 gene:...	[more]
unc-42	4.793e-39	76.09	pep chromosome:WBcel235:V:9764645:9767679:-1 gene:...	[more]
unc-42	1.616e-36	74.44	pep chromosome:WBcel235:V:9764645:9769361:-1 gene:...	[more]
unc-42	2.350e-36	74.44	pep chromosome:WBcel235:V:9764645:9767679:-1 gene:...	[more]
ceh-10	1.656e-22	70.77	Homeobox protein ceh-10 [Source:UniProtKB/Swiss-P...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG32532	1.490e-46	80.61	gene:FBgn0052532 transcript:FBtr0340418	[more]
CG32532	1.744e-46	80.61	gene:FBgn0052532 transcript:FBtr0340419	[more]
CG32532	7.501e-45	80.61	gene:FBgn0052532 transcript:FBtr0340420	[more]
Pph13	4.346e-23	70.49	gene:FBgn0023489 transcript:FBtr0078070	[more]
al	4.601e-23	63.51	gene:FBgn0000061 transcript:FBtr0078053	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
prop1	6.816e-29	62.79	PROP paired-like homeobox 1 [Source:ZFIN;Acc:ZDB-G...	[more]
prop1	6.816e-29	62.79	PROP paired-like homeobox 1 [Source:ZFIN;Acc:ZDB-G...	[more]
prop1	8.210e-29	62.79	PROP paired-like homeobox 1 [Source:ZFIN;Acc:ZDB-G...	[more]
alx1	6.964e-24	70.49	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]
alx1	6.964e-24	70.49	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSXETT00000043226.1	9.822e-26	65.00	PROP paired-like homeobox 1 [Source:NCBI gene;Acc:...	[more]
ALX1	2.769e-23	70.49	ALX homeobox 1 [Source:NCBI gene;Acc:100489661]	[more]
ENSXETT00000045443.1	8.693e-23	62.86	pep primary_assembly:Xenopus_tropicalis_v9.1:8:382...	[more]
ARX	8.699e-23	64.79	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
PAX7	8.741e-23	72.88	paired box 7 [Source:NCBI gene;Acc:100496502]	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Alx1	1.467e-23	70.49	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]
Alx1	2.486e-23	70.49	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]
Alx1	2.486e-23	70.49	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]
Alx1	2.486e-23	70.49	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]
Alx1	2.486e-23	70.49	ALX homeobox 1 [Source:MGI Symbol;Acc:MGI:104621]	[more]

BLAST of Aristaless-like homeobox transcription factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q1LVQ7\|ALX1_DANRE	5.257e-23	70.49	ALX homeobox protein 1 OS=Danio rerio OX=7955 GN=a...	[more]
sp\|Q3LU40\|PROP1_SAPAP	1.107e-22	67.65	Homeobox protein prophet of Pit-1 OS=Sapajus apell...	[more]
sp\|Q91574\|ALX1_XENLA	1.570e-22	70.49	ALX homeobox protein 1 OS=Xenopus laevis OX=8355 G...	[more]
sp\|Q9GLL9\|PROP1_PIG	1.676e-22	67.65	Homeobox protein prophet of Pit-1 OS=Sus scrofa OX...	[more]
sp\|Q63087\|ALX1_RAT	1.690e-22	70.49	ALX homeobox protein 1 OS=Rattus norvegicus OX=101...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1L2TQQ2	0.000e+0	99.58	Aristaless-like homeobox transcription factor OS=S...	[more]
N6UEP6	1.002e-50	46.27	Homeobox domain-containing protein (Fragment) OS=D...	[more]
D2A067	9.908e-50	45.88	ALX homeobox protein 1-like Protein OS=Tribolium c...	[more]
U4UTX9	1.619e-48	81.19	Homeobox domain-containing protein OS=Dendroctonus...	[more]
A0A1I8HK83	2.050e-48	84.54	Homeobox domain-containing protein OS=Macrostomum ...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000049958.1	4.434e-28	73.91	homeobox protein prophet of Pit-1-like [Source:NCB...	[more]
alx1	7.890e-24	63.16	ALX homeobox 1 [Source:NCBI gene;Acc:565176]	[more]
rx2	5.145e-23	59.74	retinal homeobox protein Rx2-like [Source:NCBI gen...	[more]
alx4a	1.530e-22	68.85	ALX homeobox 4 [Source:NCBI gene;Acc:103046081]	[more]
pax7b	1.832e-22	72.88	paired box protein Pax-7-like [Source:NCBI gene;Ac...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmbx1b	1.192e-20	58.82	diencephalon/mesencephalon homeobox 1b [Source:NCB...	[more]
ENSPMAT00000010761.1	4.904e-17	57.38	pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-...	[more]
ENSPMAT00000011473.1	3.779e-11	49.12	pep scaffold:Pmarinus_7.0:GL476736:88393:88668:-1 ...	[more]
otx5	2.260e-10	52.73	orthodenticle homolog 5 [Source:ZFIN;Acc:ZDB-GENE-...	[more]
ENSPMAT00000009847.1	3.487e-10	50.00	pep scaffold:Pmarinus_7.0:GL481168:3356:14379:1 ge...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
PHO2	9.549e-7	30.95	Homeobox transcription factor; regulatory targets ...	[more]
YOX1	2.067e-6	37.68	Homeobox transcriptional repressor; binds to Mcm1p...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO38926	1.214e-23	61.76	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43002	2.502e-22	65.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42103	6.993e-22	63.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42147	1.088e-21	62.50	Predicted protein; Retinal homeobox [Source:UniPr...	[more]
EDO39160	1.128e-21	67.21	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000001768.2	3.790e-31	64.37	homeobox protein prophet of Pit-1-like [Source:NCB...	[more]
alx1	5.415e-24	70.49	ALX homeobox 1 [Source:NCBI gene;Acc:101154901]	[more]
pax7	1.420e-22	72.88	paired box 7 [Source:NCBI gene;Acc:101174017]	[more]
rx2	1.690e-22	66.67	Rx2 transcription factor [Source:NCBI gene;Acc:100...	[more]
alx4b	1.856e-22	68.85	homeobox protein aristaless-like 4 [Source:NCBI ge...	[more]

BLAST of Aristaless-like homeobox transcription factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000030143.1	0.000e+0	99.79	SMESG000030143.1	[more]
SMESG000033843.1	2.904e-23	54.55	SMESG000033843.1	[more]
SMESG000052478.1	3.986e-22	68.85	SMESG000052478.1	[more]
SMESG000080420.1	4.824e-22	58.11	SMESG000080420.1	[more]
SMESG000080420.1	5.642e-22	58.11	SMESG000080420.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30020992 ID=SMED30020992|Name=Aristaless-like homeobox transcription factor|organism=Schmidtea mediterranea sexual|type=transcript|length=1769bp
ATTAACTTTGTCAAATATCTTTATTAAGCACCATTAAATCATTTATTGAA
GGCCTTCTTGATTGGATCCAGGAAACAAGATTAGTTTTTAGACAATGTAT
GAAAATTCTGTGGCTAGCCAGTACGAAAACAACACCAATAATATCATTAA
CAACAACAACAACAACCACAGCAGGAACAACAACAACAACAATAATAGTA
ATACTAATAACAACATCTATAATTTGAAACCAATAATGACTGAAGCTGGC
AACAAGTTTTTCAATCAATGCAACGAGAAGTTATTTAAACGAGACGATTA
TTTCCCGGGTCTCGTCAATGGATCTGGTTTGCCAGCAATGGTCCATCCGG
ACAGTTTATTCCATCCTATTTCCGGTTCCATGTTTGGTTCACATCTTTCA
GCGTTCCCGTCAAATCAATCCCTTTATCCTCCACATTTGCAATACAATCT
CTCGTCGTTACAGCAACAAATGCCATTGAATATCAACAATTCCTGTTTCG
CTAATGATTCCAATTGCGTCAGTCCCGGTATCGAAAACAGTTTCAAAAAA
ATGAAGACCGAATGCCTAAATAATATCCAAAGCTCAATTTTCAATTCAGC
ATCATTATCACTAAATGAAACTGATATAAAAGTGTCCAGCAATTTGACAT
CTCCAACATCAGTTTTTTCATCAAATACTGGTCTCAATAATAACAATAAT
AACAATAACAACAGCACTAATAAATCATCGATATTGAATCAGAATTCCTC
TGGTCCGATCAATGCGTCATCAGCGTCCAATCAGGTGTCCATATCCGCAA
ATACCGTCCATTCCCAGTCCACGAATATCAATCAATCAGAAAAACCCATT
ATAGACCCGTTGACAAGCAGTAGTCTTAGCAACACATGCATCTCCACAAG
TAGTTGTCCCACTACAATCAGTAATAACAATAGTCATGGTCATCACAATC
CCACAGTGAACAGTTGTCCCACACCCGCCCGAAGACGGCATAGAACCACT
TTCACACAGGAACAGTTACAAGAGCTGGAGTCGGCGTTTCAGAAAAGTCA
TTATCCGGATATCTACTGTCGAGAAGAATTAGCTCGAATTACTAAATTAA
ATGAAGCCAGAATTCAAGTATGGTTTCAAAACCGGCGAGCAAAATATCGA
AAACAAGAGAAACAATTGACCAAACAACTACATCCTAGTCTTCCGTCTTG
TAATACGGCTATAATGAGATCTATGTATCCGAGTGGGGTATGTGGAGTTA
ACACTGTGAACGCAGTCGTTGGAGTCGGTAATCGGGTACCGAGCTCAATT
AACGGCAATAATGCGTCGGCTTATTCGAATTATTGCAGTTCCACAGTTGC
TGCTGCTAGAAATTATGTACAAATTCCCCATGCAGCATCGAACTATAATG
GCTTAGCTACTTCATTCGGAAACATGAACTCCAACCATCACACAAACAAC
ATGACACTTCCTCCAATCGCCGGCTCCGCAGTAAACAATTCTCTTTCGAA
TCACTACTCAAATTTGTTCTGGTGGACGGGAAATCAAGATTTGCAAGAAA
ATATGAGTCTAGAAGATTCATCGGAAAACGACTGGTACAAGGCCAGCTTA
TCAGCTCTTAATGGCTCGCATAATGCCCTTGGTAATCCAATTTTACCATA
TCATTCTTAGATATCACTTCTTTAGTTTAATATGTTCACTCTAATCTATA
TCAAATTTTGCTAATTTATTTATTTGTTGTATATATTTGTTACATTTTCC
CTGTATAAAGAAAAGCATC

protein sequence of SMED30020992-orf-1

>SMED30020992-orf-1 ID=SMED30020992-orf-1|Name=SMED30020992-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=522bp
MYENSVASQYENNTNNIINNNNNNHSRNNNNNNNSNTNNNIYNLKPIMTE
AGNKFFNQCNEKLFKRDDYFPGLVNGSGLPAMVHPDSLFHPISGSMFGSH
LSAFPSNQSLYPPHLQYNLSSLQQQMPLNINNSCFANDSNCVSPGIENSF
KKMKTECLNNIQSSIFNSASLSLNETDIKVSSNLTSPTSVFSSNTGLNNN
NNNNNNSTNKSSILNQNSSGPINASSASNQVSISANTVHSQSTNINQSEK
PIIDPLTSSSLSNTCISTSSCPTTISNNNSHGHHNPTVNSCPTPARRRHR
TTFTQEQLQELESAFQKSHYPDIYCREELARITKLNEARIQVWFQNRRAK
YRKQEKQLTKQLHPSLPSCNTAIMRSMYPSGVCGVNTVNAVVGVGNRVPS
SINGNNASAYSNYCSSTVAAARNYVQIPHAASNYNGLATSFGNMNSNHHT
NNMTLPPIAGSAVNNSLSNHYSNLFWWTGNQDLQENMSLEDSSENDWYKA
SLSALNGSHNALGNPILPYHS*

Aliases

The feature 'Aristaless-like homeobox transcription factor' has the following synonyms


Synonym
pax3/7-like

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000097	ventral nerve cord
PLANA:0000099	neuron
PLANA:0000103	central nervous system
PLANA:0000142	posterior region of the whole animal
PLANA:0000419	prepharyngeal region
PLANA:0000463	cholinergic neuron
PLANA:0000464	GABAergic neuron
PLANA:0000483	octopaminergic neuron
PLANA:0002089	reproductive organ
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 296..358 e-value: 8.9E-25 score: 98.3
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 297..353 e-value: 8.9E-22 score: 76.7
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 294..354 score: 20.666
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 297..355 e-value: 3.81747E-25 score: 96.1584
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 284..358 e-value: 4.4E-28 score: 98.8
None	No IPR available	PANTHER	PTHR24329:SF520		coord: 181..520
None	No IPR available	PANTHER	PTHR24329	FAMILY NOT NAMED	coord: 181..520
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 329..352
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 280..356