Eukaryotic translation initiation factor 2 subunit 2
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020990 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 19Note: Hover over icons to view figure legend
Homology
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Match: EIF2S2 (eukaryotic translation initiation factor 2 subunit beta [Source:HGNC Symbol;Acc:HGNC:3266]) HSP 1 Score: 124.79 bits (312), Expect = 1.681e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 191 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 331
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Match: EIF5 (eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299]) HSP 1 Score: 53.9138 bits (128), Expect = 1.917e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Match: EIF5 (eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299]) HSP 1 Score: 53.5286 bits (127), Expect = 1.206e-6 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Match: EIF5 (eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299]) HSP 1 Score: 53.5286 bits (127), Expect = 1.206e-6 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Match: EIF5 (eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299]) HSP 1 Score: 53.5286 bits (127), Expect = 1.206e-6 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Celegans
Match: eif-2beta (Eukaryotic translation initiation factor 2 subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q21230]) HSP 1 Score: 122.094 bits (305), Expect = 8.993e-31 Identity = 54/124 (43.55%), Postives = 84/124 (67.74%), Query Frame = 1
Query: 670 PSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRR 1041
P +A+ G+ KT F+NF +C+ + R ++V Q+L E+G+T S+D +N LI++GR+Q Q ES++ Y K YV+C C+S T+L +TR+ FL C CGSR ++ +G+KA+ +RAAIRR
Sbjct: 119 PEVARAGSKKTAFSNFLEICRLMKRQDKHVLQFLLAELGTTGSIDGSNCLIVKGRWQQKQFESVLRKYIKEYVMCHTCKSPETQLTKDTRLFFLQCTNCGSRCSVTAIKSGFKAVVGKRAAIRR 242
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Celegans
Match: eif-2beta (Eukaryotic translation initiation factor 2 subunit 2 [Source:UniProtKB/Swiss-Prot;Acc:Q21230]) HSP 1 Score: 122.094 bits (305), Expect = 8.993e-31 Identity = 54/124 (43.55%), Postives = 84/124 (67.74%), Query Frame = 1
Query: 670 PSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRR 1041
P +A+ G+ KT F+NF +C+ + R ++V Q+L E+G+T S+D +N LI++GR+Q Q ES++ Y K YV+C C+S T+L +TR+ FL C CGSR ++ +G+KA+ +RAAIRR
Sbjct: 119 PEVARAGSKKTAFSNFLEICRLMKRQDKHVLQFLLAELGTTGSIDGSNCLIVKGRWQQKQFESVLRKYIKEYVMCHTCKSPETQLTKDTRLFFLQCTNCGSRCSVTAIKSGFKAVVGKRAAIRR 242
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Fly
Match: eIF2beta (gene:FBgn0004926 transcript:FBtr0075968) HSP 1 Score: 127.872 bits (320), Expect = 5.443e-32 Identity = 57/126 (45.24%), Postives = 87/126 (69.05%), Query Frame = 1
Query: 667 PPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
PP + ++GT KT F NF + K L+R +++ +L E+G++ S+D N QLI++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C++CGSR ++A +G++A+T +RAAIR K
Sbjct: 185 PPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQQLIIKGRFQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQAVTGKRAAIRAK 310
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Match: eif2s2 (eukaryotic translation initiation factor 2, subunit 2 beta [Source:ZFIN;Acc:ZDB-GENE-030131-3085]) HSP 1 Score: 124.79 bits (312), Expect = 5.689e-31 Identity = 56/132 (42.42%), Postives = 89/132 (67.42%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 194 RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 325 HSP 2 Score: 30.8018 bits (68), Expect = 5.689e-31 Identity = 10/30 (33.33%), Postives = 19/30 (63.33%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY Y+E+L +++ + + NP ++ G K K
Sbjct: 167 DYTYDELLNRVFNIMREKNPDMVAGEKRKF 196
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Match: smcr8a (Smith-Magenis syndrome chromosome region, candidate 8a [Source:NCBI gene;Acc:558696]) HSP 1 Score: 38.891 bits (89), Expect = 3.050e-7 Identity = 21/67 (31.34%), Postives = 34/67 (50.75%), Query Frame = 2
Query: 1637 VFTNMLTAN**IMIFLESINEEIIILAHFCELVGPMHLIVWPDKPGI-DNKTIDMVVLKAMSVDYQA 1834
+FT+ AN +++ I+++ F E VGP L+ P P + ++ L+ MSVDYQA
Sbjct: 34 LFTHAANANPWTKTSYAKFSKDFILISEFSEQVGPQPLLTIPSDPKVCGTFDLNYFSLRIMSVDYQA 100 HSP 2 Score: 36.5798 bits (83), Expect = 3.050e-7 Identity = 14/30 (46.67%), Postives = 20/30 (66.67%), Query Frame = 3
Query: 1944 AVSQVHYFTLWDVYARGYVRPSCIIVCCRD 2033
A + VH+ TL+D+ ARG+VRP C+ D
Sbjct: 131 AFAYVHHLTLYDLEARGFVRPFCMAYISAD 160
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Match: eif5 (eukaryotic translation initiation factor 5 [Source:ZFIN;Acc:ZDB-GENE-030131-975]) HSP 1 Score: 50.8322 bits (120), Expect = 5.672e-6 Identity = 26/99 (26.26%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR ++ E+G+ + D +N++ I+ G + ++++ ++ + + +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDSKNDRYIVNGSHEANKLQDMLDGFIRKFVLCPECDNPETDLHINPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Match: eif5 (eukaryotic translation initiation factor 5 [Source:ZFIN;Acc:ZDB-GENE-030131-975]) HSP 1 Score: 50.8322 bits (120), Expect = 5.672e-6 Identity = 26/99 (26.26%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR ++ E+G+ + D +N++ I+ G + ++++ ++ + + +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDSKNDRYIVNGSHEANKLQDMLDGFIRKFVLCPECDNPETDLHINPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Match: eif5 (eukaryotic translation initiation factor 5 [Source:ZFIN;Acc:ZDB-GENE-030131-975]) HSP 1 Score: 50.8322 bits (120), Expect = 5.672e-6 Identity = 26/99 (26.26%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR ++ E+G+ + D +N++ I+ G + ++++ ++ + + +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDSKNDRYIVNGSHEANKLQDMLDGFIRKFVLCPECDNPETDLHINPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Xenopus
Match: eif2s2 (Xenopus tropicalis eukaryotic translation initiation factor 2 subunit beta (eif2s2), mRNA. [Source:RefSeq mRNA;Acc:NM_001364949]) HSP 1 Score: 125.176 bits (313), Expect = 1.389e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 192 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 332
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Xenopus
Match: eif5 (eukaryotic translation initiation factor 5 [Source:NCBI gene;Acc:493571]) HSP 1 Score: 53.9138 bits (128), Expect = 8.158e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Xenopus
Match: eif5 (eukaryotic translation initiation factor 5 [Source:NCBI gene;Acc:493571]) HSP 1 Score: 53.9138 bits (128), Expect = 8.669e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Match: Eif2s2 (eukaryotic translation initiation factor 2, subunit 2 (beta) [Source:MGI Symbol;Acc:MGI:1914454]) HSP 1 Score: 125.176 bits (313), Expect = 1.008e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 189 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 329
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Match: Eif2s2 (eukaryotic translation initiation factor 2, subunit 2 (beta) [Source:MGI Symbol;Acc:MGI:1914454]) HSP 1 Score: 125.176 bits (313), Expect = 1.008e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 189 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 329
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Match: Eif5 (eukaryotic translation initiation factor 5 [Source:MGI Symbol;Acc:MGI:95309]) HSP 1 Score: 53.9138 bits (128), Expect = 5.478e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Match: Eif5 (eukaryotic translation initiation factor 5 [Source:MGI Symbol;Acc:MGI:95309]) HSP 1 Score: 53.9138 bits (128), Expect = 7.239e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Match: Eif5 (eukaryotic translation initiation factor 5 [Source:MGI Symbol;Acc:MGI:95309]) HSP 1 Score: 53.9138 bits (128), Expect = 7.239e-7 Identity = 28/99 (28.28%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR +Y E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Match: sp|P41375|IF2B_DROME (Eukaryotic translation initiation factor 2 subunit 2 OS=Drosophila melanogaster OX=7227 GN=eIF2beta PE=1 SV=1) HSP 1 Score: 127.872 bits (320), Expect = 5.456e-31 Identity = 57/126 (45.24%), Postives = 87/126 (69.05%), Query Frame = 1
Query: 667 PPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
PP + ++GT KT F NF + K L+R +++ +L E+G++ S+D N QLI++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C++CGSR ++A +G++A+T +RAAIR K
Sbjct: 185 PPQVLRVGTKKTSFANFMDIAKTLHRLPKHLLDFLLAELGTSGSMDGNQQLIIKGRFQPKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLFFLQCESCGSRCSVASIKSGFQAVTGKRAAIRAK 310
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Match: sp|Q5E9D0|IF2B_BOVIN (Eukaryotic translation initiation factor 2 subunit 2 OS=Bos taurus OX=9913 GN=EIF2S2 PE=2 SV=1) HSP 1 Score: 124.79 bits (312), Expect = 1.619e-30 Identity = 56/132 (42.42%), Postives = 89/132 (67.42%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 200 RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGRRAQLRAK 331 HSP 2 Score: 31.9574 bits (71), Expect = 1.619e-30 Identity = 11/30 (36.67%), Postives = 19/30 (63.33%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY YEE+L +++ + + NP ++ G K K
Sbjct: 173 DYTYEELLNRVFNIMREKNPDMVAGEKRKF 202
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Match: sp|Q99L45|IF2B_MOUSE (Eukaryotic translation initiation factor 2 subunit 2 OS=Mus musculus OX=10090 GN=Eif2s2 PE=1 SV=1) HSP 1 Score: 125.176 bits (313), Expect = 7.049e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 189 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 329
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Match: sp|P41035|IF2B_RABIT (Eukaryotic translation initiation factor 2 subunit 2 OS=Oryctolagus cuniculus OX=9986 GN=EIF2S2 PE=1 SV=1) HSP 1 Score: 125.176 bits (313), Expect = 7.415e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 191 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 331
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Match: sp|P20042|IF2B_HUMAN (Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2) HSP 1 Score: 124.79 bits (312), Expect = 8.074e-30 Identity = 59/142 (41.55%), Postives = 92/142 (64.79%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 191 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 331
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Match: A0A3P8HZS3 (eIF2B_5 domain-containing protein OS=Trichobilharzia regenti OX=157069 GN=TRE_LOCUS12893 PE=4 SV=1) HSP 1 Score: 139.428 bits (350), Expect = 2.562e-34 Identity = 59/132 (44.70%), Postives = 94/132 (71.21%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R++ +VPP +A++GT KT F NF +C+ LNRD ++ Y+ E+G+ S+D N L++RGR+ +E ++ NYC+TYVLC C+SS T+L ++R+LFL+C+ CGSR + ++G++ALT +RAA+R K
Sbjct: 22 RKLVMVPPQMARVGTKKTLFVNFSTICRSLNRDQSHLTTYILTELGTQGSVDANGALLIRGRYTSKHMEPVLRNYCRTYVLCGTCQSSETDLCKDSRLLFLHCRRCGSRFTVKTVTSGFQALTGKRAALRAK 153
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Match: A0A183WL90 (eIF2B_5 domain-containing protein OS=Trichobilharzia regenti OX=157069 PE=4 SV=1) HSP 1 Score: 139.043 bits (349), Expect = 2.689e-34 Identity = 59/132 (44.70%), Postives = 94/132 (71.21%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R++ +VPP +A++GT KT F NF +C+ LNRD ++ Y+ E+G+ S+D N L++RGR+ +E ++ NYC+TYVLC C+SS T+L ++R+LFL+C+ CGSR + ++G++ALT +RAA+R K
Sbjct: 22 RKLVMVPPQMARVGTKKTLFVNFSTICRSLNRDQSHLTTYILTELGTQGSVDANGALLIRGRYTSKHMEPVLRNYCRTYVLCGTCQSSETDLCKDSRLLFLHCRRCGSRFTVKTVTSGFQALTGKRAALRAK 153
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Match: A0A0R3VU99 (eIF2B_5 domain-containing protein OS=Taenia asiatica OX=60517 PE=4 SV=1) HSP 1 Score: 140.198 bits (352), Expect = 1.123e-33 Identity = 61/132 (46.21%), Postives = 92/132 (69.70%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R + + PP +A++GT KT FTNF +C+ LNRD ++ YL E+G+T S+D N L++RG++Q IE ++ NY +TYVLC C+S +TEL ++R+LFL CK C SR + ++G++A+T +RAAIR K
Sbjct: 97 RRLVMAPPCMARVGTKKTHFTNFNGICRSLNRDPAHLSAYLFAELGTTGSVDANGALLIRGKYQAKHIEPVLRNYARTYVLCSTCQSPDTELSRDSRLLFLQCKTCRSRVTVKSVTSGFQAVTGKRAAIRAK 228
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Match: A0A3P6NH39 (eIF2B_5 domain-containing protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS878 PE=4 SV=1) HSP 1 Score: 140.198 bits (352), Expect = 1.145e-33 Identity = 61/132 (46.21%), Postives = 92/132 (69.70%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R + + PP +A++GT KT FTNF +C+ LNRD ++ YL E+G+T S+D N L++RG++Q IE ++ NY +TYVLC C+S +TEL ++R+LFL CK C SR + ++G++A+T +RAAIR K
Sbjct: 97 RRLVMAPPCMARVGTKKTHFTNFNGICRSLNRDPAHLSAYLFAELGTTGSVDANGALLIRGKYQAKHIEPVLRNYARTYVLCSTCQSPDTELSRDSRLLFLQCKTCRSRVTVKSVTSGFQAVTGKRAAIRAK 228
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Match: A0A226EFB5 (Eukaryotic translation initiation factor 2 subunit 2 OS=Folsomia candida OX=158441 GN=Fcan01_09688 PE=4 SV=1) HSP 1 Score: 137.887 bits (346), Expect = 1.805e-33 Identity = 60/126 (47.62%), Postives = 91/126 (72.22%), Query Frame = 1
Query: 667 PPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
PP + ++GT KT F NF +CK L+R +++ +L +E+G++ S+D NNQLI++G+FQ QIE+++ Y K YV C CRS NT L+ ++RI FL C+ACGSR ++A G++A+T++RAAIR K
Sbjct: 202 PPQVLRVGTKKTSFVNFMEICKMLHRHQKHLLDFLLSELGTSGSIDGNNQLIIKGKFQQKQIENVLRRYIKEYVTCHTCRSPNTILQKDSRIFFLQCEACGSRCSVASIKHGFQAVTSKRAAIRAK 327 HSP 2 Score: 36.5798 bits (83), Expect = 1.805e-33 Identity = 12/30 (40.00%), Postives = 22/30 (73.33%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY YEE+L ++++ ++ NP++ GTK+K
Sbjct: 169 DYTYEELLTRVFEIMHAKNPEMASGTKQKF 198
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Match: ENSAMXT00000031380.1 (eukaryotic translation initiation factor 2 subunit 2-like [Source:NCBI gene;Acc:103026522]) HSP 1 Score: 123.635 bits (309), Expect = 2.130e-30 Identity = 59/142 (41.55%), Postives = 91/142 (64.08%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G+ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 182 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTCGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 322
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:103029442]) HSP 1 Score: 122.479 bits (306), Expect = 5.204e-30 Identity = 59/142 (41.55%), Postives = 90/142 (63.38%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G+ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 184 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTCGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 324
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:103029442]) HSP 1 Score: 122.479 bits (306), Expect = 5.929e-30 Identity = 59/142 (41.55%), Postives = 90/142 (63.38%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G+ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 189 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTCGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 329
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:103029442]) HSP 1 Score: 122.479 bits (306), Expect = 6.802e-30 Identity = 59/142 (41.55%), Postives = 90/142 (63.38%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G+ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 193 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTCGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 333
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:103029442]) HSP 1 Score: 103.99 bits (258), Expect = 9.232e-24 Identity = 54/142 (38.03%), Postives = 78/142 (54.93%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A G++A+T +RA +R K
Sbjct: 189 NPDMVAGEK-RKFVMKPPQVVRVGTKKTSFVNFTDICKF-------------------GSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAK 310
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Sea Lamprey
Match: eif2s2 (eukaryotic translation initiation factor 2, subunit 2 beta [Source:ZFIN;Acc:ZDB-GENE-030131-3085]) HSP 1 Score: 123.635 bits (309), Expect = 2.358e-32 Identity = 58/132 (43.94%), Postives = 91/132 (68.94%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R+ + PP + ++GT K+ F NF +CK L+R +++ +L +E+G++ S+D NNQLI++GRFQ QIES++ Y K YV C CRS +T L+ +TR+ FL C+ C SR ++A AG++A+T +RA +R K
Sbjct: 212 RKFVMKPPQVVRVGTKKSSFANFAEICKLLHRQPKHLLLFLLSELGTSGSIDGNNQLIIKGRFQQKQIESVLRRYIKEYVTCHTCRSPDTTLQKDTRLYFLQCETCHSRCSVASIKAGFQAVTGKRAQMRAK 343 HSP 2 Score: 34.2686 bits (77), Expect = 2.358e-32 Identity = 11/30 (36.67%), Postives = 20/30 (66.67%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY Y+E+L +++ + + NP++M G K K
Sbjct: 185 DYTYDELLSRVFNIMREKNPEMMAGEKRKF 214
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003773.1 (pep scaffold:Pmarinus_7.0:GL476420:783557:940008:-1 gene:ENSPMAG00000003445.1 transcript:ENSPMAT00000003773.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 45.0542 bits (105), Expect = 4.240e-6 Identity = 22/77 (28.57%), Postives = 40/77 (51.95%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTEL 924
KT N V K LNR +Y E+G+ + D +N + I+ G + ++++ ++ + K +VLC C + T+L
Sbjct: 33 KTVVVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDAKNERYIVNGSHESNRLQDMLDGFIKKFVLCPECENPETDL 109
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Yeast
Match: SUI3 (Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding [Source:SGD;Acc:S000006158]) HSP 1 Score: 93.2041 bits (230), Expect = 2.829e-21 Identity = 43/123 (34.96%), Postives = 76/123 (61.79%), Query Frame = 1
Query: 664 VPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESE--TRILFLNCKACGSRNAIAKQSAGYKALTTQR 1026
+PP + KT F+N + + L+R E++ QYL E+G++ S+D +L+++G+FQ Q+E+++ Y YV C+ C+S NTEL+ E R+ F+ CK+CGS +++ G++A +R
Sbjct: 160 IPPPVCLRDGKKTIFSNIQDIAEKLHRSPEHLIQYLFAELGTSGSVDGQKRLVIKGKFQSKQMENVLRRYILEYVTCKTCKSINTELKREQSNRLFFMVCKSCGSTRSVSSIKTGFQATVGKR 282
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Yeast
Match: TIF5 (Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 [Source:SGD;Acc:S000006245]) HSP 1 Score: 49.6766 bits (117), Expect = 1.374e-6 Identity = 28/113 (24.78%), Postives = 58/113 (51.33%), Query Frame = 1
Query: 664 VPPSLAKL----GTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTE-LESETRILFLNCKACGSRNAI 984
+PP AK+ KT N + LNR + +Y E+G+ +S+ ++ ++ G + ++++ ++ + +VLC +C++ TE + ++ L +CKACG R +
Sbjct: 18 MPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPYIVKYFGFELGAQTSISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSCKNPETEIIITKDNDLVRDCKACGKRTPM 130
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Nematostella
Match: EDO41575 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3Z5]) HSP 1 Score: 134.035 bits (336), Expect = 1.426e-35 Identity = 62/142 (43.66%), Postives = 94/142 (66.20%), Query Frame = 1
Query: 619 NESSVNGRN*REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
N V G R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQLI++GRFQ QIES++ Y K YV C CRS +T L+ ETR+ FL C+ CGSR ++A +G++A+T +RA ++ K
Sbjct: 79 NPDMVAGEK-RKFVMKPPQVVRIGTKKTSFANFTDICKILHRQPKHLLAFLLAELGTSGSIDGNNQLIIKGRFQQKQIESVLRRYIKEYVTCHTCRSPDTILQKETRLFFLQCETCGSRCSVASIKSGFQAITGKRAQLKNK 219
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Nematostella
Match: EDO43054 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RZU8]) HSP 1 Score: 52.7582 bits (125), Expect = 4.471e-7 Identity = 29/99 (29.29%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRI--LFLNCKACGSRNAI 984
KT N + K L+R +Y E+G+ + +D +N + I+ G Q +++ ++ + + +VLC +C + T L +TR + NCKACG + I
Sbjct: 34 KTVIVNMPDIAKALSRPPSYPTKYFGCELGAQTQIDLKNERYIVNGAHQADKLQEILDGFIERFVLCSSCENPETVLVVDTRKERIGQNCKACGHQGFI 132
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Medaka
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:101162925]) HSP 1 Score: 127.102 bits (318), Expect = 9.695e-32 Identity = 57/132 (43.18%), Postives = 90/132 (68.18%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R+ + PP + ++GT KT F NF +CK L+R +++ +L E+G++ S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A AG++A+T++RA +R K
Sbjct: 198 RKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKAGFQAVTSKRAQLRAK 329 HSP 2 Score: 31.187 bits (69), Expect = 9.695e-32 Identity = 10/30 (33.33%), Postives = 19/30 (63.33%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY Y+E+L +++ + + NP ++ G K K
Sbjct: 171 DYTYDELLNRVFNIMREKNPDMVAGEKRKF 200
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Medaka
Match: eif2s2 (eukaryotic translation initiation factor 2 subunit beta [Source:NCBI gene;Acc:101162925]) HSP 1 Score: 107.071 bits (266), Expect = 7.133e-26 Identity = 53/135 (39.26%), Postives = 81/135 (60.00%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCL---NRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
R+ + PP + ++GT KT F NF +CK L + + + S+D NNQL+++GRFQ QIE+++ Y K YV C CRS T L+ +TR+ FL C+ C SR ++A AG++A+T++RA +R K
Sbjct: 193 RKFVMKPPQVVRVGTKKTSFVNFTDICKLLVSGKHKLSVIFFFFGTNSLCLGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPETILQKDTRLYFLQCETCHSRCSVASIKAGFQAVTSKRAQLRAK 327 HSP 2 Score: 31.187 bits (69), Expect = 7.133e-26 Identity = 10/30 (33.33%), Postives = 19/30 (63.33%), Query Frame = 2
Query: 569 DYNYEEMLMKIYKKLYQTNPQLMGGTKEKL 658
DY Y+E+L +++ + + NP ++ G K K
Sbjct: 166 DYTYDELLNRVFNIMREKNPDMVAGEKRKF 195
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Medaka
Match: smcr8a (SMCR8-C9orf72 complex subunit [Source:NCBI gene;Acc:101168121]) HSP 1 Score: 38.1206 bits (87), Expect = 1.802e-7 Identity = 34/113 (30.09%), Postives = 51/113 (45.13%), Query Frame = 3
Query: 1944 AVSQVHYFTLWDVYARGYVRPSCIIVCCRDRM*IYSL**VLTF*LRFRRAKELFFAKYR-----ELNQILKAWLERNINHFYQELNTSKEMVDKILSCNKNVNVCDNILTVEK 2267
A + VH+ TL+D+ ARG+VRP C+ D I L+ LRF +A E A R EL + L+ LE + +E +E + + V + + VEK
Sbjct: 144 AFAYVHHLTLYDLEARGFVRPFCMAYVTADEKKIMQQFQELS--LRFSQASECLKAGNRRAFAKELQRKLQD-LEYTHSVLQKEEGLQREAGPQSMYSAHAVEKANELANVEK 253 HSP 2 Score: 37.7354 bits (86), Expect = 1.802e-7 Identity = 18/47 (38.30%), Postives = 28/47 (59.57%), Query Frame = 2
Query: 1697 EEIIILAHFCELVGPMHLIVWPDKPGI-DNKTIDMVVLKAMSVDYQA 1834
++ I+++ F E VGP L+ PD P + ++ L+ MSVDYQA
Sbjct: 67 KDFILISEFSEQVGPQPLLTIPDDPKVCGTFDLNYFSLRIMSVDYQA 113
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Medaka
Match: eif5 (eukaryotic translation initiation factor 5 [Source:NCBI gene;Acc:101174714]) HSP 1 Score: 52.7582 bits (125), Expect = 1.242e-6 Identity = 27/99 (27.27%), Postives = 52/99 (52.53%), Query Frame = 1
Query: 697 KTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLD-QNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELE--SETRILFLNCKACGSRNAI 984
KT N V K LNR ++ E+G+ + D +N++ I+ G + ++++ ++ + K +VLC C + T+L + + + +CKACG R +
Sbjct: 33 KTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDTKNDRYIVNGSHEANKLQDMLDGFIKKFVLCAECDNPETDLHVNPKKQTIGTSCKACGYRGML 131
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Match: SMESG000017124.1 (SMESG000017124.1) HSP 1 Score: 507.679 bits (1306), Expect = 0.000e+0 Identity = 253/273 (92.67%), Postives = 254/273 (93.04%), Query Frame = 3
Query: 1956 VHYFTLWDVYARGYVRPSCIIVCCRDRM*IYSL**VLTF*LRFRRAKELFFAKYRELNQILKAWLERNINHFYQELNTSKEMVDKILSCNKNVNVCDNILTVEKDFNIKKLSYLHGEYCNLISNIREHDKNIKVTKKSISHDVLLDVNIALSSDGKELRSIYELIEMTEEEMKNEIKNIWKSFANTLVSESFSLRESDFHQQISSGLFDTLTSKRNPKFNVQYFGTAFSLDK---NIGKSAPLCLCRTILDNLSPIEKFQNFENLQEDVIFPN 2765
VHYFTLWDVYARGYVRPSCIIVCCRDR+ RAKELFFAKYRELNQILKAWLERNINHFYQELNTSKEMVDKILSCNKNVNVCDNILTVEKDFNIKKLSYLHGEYCNLISNIREHDKNIKVTKKSISHDVLLDVNIALSSDGKELRSIYELIEMTEEEMKNEIKNIWKSFANTLVSESFSLRESDFHQQISSGLFDTLTSKRNPKFNVQYFGTAFSLDK NIGKSAPLCLCRTILDNLSPIEKFQNFENLQEDVIFPN
Sbjct: 118 VHYFTLWDVYARGYVRPSCIIVCCRDRI----------------RAKELFFAKYRELNQILKAWLERNINHFYQELNTSKEMVDKILSCNKNVNVCDNILTVEKDFNIKKLSYLHGEYCNLISNIREHDKNIKVTKKSISHDVLLDVNIALSSDGKELRSIYELIEMTEEEMKNEIKNIWKSFANTLVSESFSLRESDFHQQISSGLFDTLTSKRNPKFNVQYFGTAFSLDKSILNIGKSAPLCLCRTILDNLSPIEKFQNFENLQEDVIFPN 374 HSP 2 Score: 158.303 bits (399), Expect = 0.000e+0 Identity = 74/75 (98.67%), Postives = 75/75 (100.00%), Query Frame = 2
Query: 1685 ESINEEIIILAHFCELVGPMHLIVWPDKPGIDNKTIDMVVLKAMSVDYQACERGDIKMDATAQTLIMDCSIPFFV 1909
+SINEEIIILAHFCELVGPMHLIVWPDKPGIDNKTIDMVVLKAMSVDYQACERGDIKMDATAQTLIMDCSIPFFV
Sbjct: 44 KSINEEIIILAHFCELVGPMHLIVWPDKPGIDNKTIDMVVLKAMSVDYQACERGDIKMDATAQTLIMDCSIPFFV 118
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Match: SMESG000078141.1 (SMESG000078141.1) HSP 1 Score: 151.369 bits (381), Expect = 3.661e-41 Identity = 63/132 (47.73%), Postives = 102/132 (77.27%), Query Frame = 1
Query: 649 REIEVVPPSLAKLGTTKTCFTNFYMVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNYCKTYVLCQACRSSNTELESETRILFLNCKACGSRNAIAKQSAGYKALTTQRAAIRRK 1044
+ + +VPP LA++GT KT F+NF + K ++R+ +V Q+L NE+G+T S+DQN+QL++RGR+ QIE+L+ NYC+ YV+C+ C+ S+T+L ++R+LFL C +CGS+ ++ +AG++A+TT+RAAIR K
Sbjct: 100 KRLRMVPPILARIGTKKTLFSNFLAITKMIHREPSHVMQFLLNEMGTTGSIDQNSQLLIRGRYMSKQIETLLKNYCRAYVICKTCQLSDTQLSKDSRLLFLICNSCGSKYSVDSHTAGFQAVTTKRAAIRAK 231
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Match: SMESG000040932.1 (SMESG000040932.1) HSP 1 Score: 107.071 bits (266), Expect = 3.408e-27 Identity = 50/50 (100.00%), Postives = 50/50 (100.00%), Query Frame = 2
Query: 2 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 151
KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS
Sbjct: 5 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 54
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Match: SMESG000027381.1 (SMESG000027381.1) HSP 1 Score: 107.457 bits (267), Expect = 5.172e-26 Identity = 50/50 (100.00%), Postives = 50/50 (100.00%), Query Frame = 2
Query: 2 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 151
KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS
Sbjct: 109 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 158
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Match: SMESG000029286.1 (SMESG000029286.1) HSP 1 Score: 108.612 bits (270), Expect = 1.691e-25 Identity = 50/50 (100.00%), Postives = 50/50 (100.00%), Query Frame = 2
Query: 2 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 151
KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS
Sbjct: 91 KSKTPVGLCSDLVYQFTCNGCNATYIGETSRHLCTRVLEHCRLKGLTNIS 140 The following BLAST results are available for this feature:
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 3
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 4
BLAST of Eukaryotic translation initiation factor 2 subunit 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020990 ID=SMED30020990|Name=Eukaryotic translation initiation factor 2 subunit 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2765bpback to top protein sequence of SMED30020990-orf-1 >SMED30020990-orf-1 ID=SMED30020990-orf-1|Name=SMED30020990-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=111bp MVCKCLNRDMENVKQYLENEVGSTSSLDQNNQLILRGRFQCSQIESLITNback to top protein sequence of SMED30020990-orf-2 >SMED30020990-orf-2 ID=SMED30020990-orf-2|Name=SMED30020990-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=189bp MVDKILSCNKNVNVCDNILTVEKDFNIKKLSYLHGEYCNLISNIREHDKNback to top protein sequence of SMED30020990-orf-3 >SMED30020990-orf-3 ID=SMED30020990-orf-3|Name=SMED30020990-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=107bp MSDINFSQIQKKKKSKIPFQKKTEILNCDFVDLFSHQLPFVGKGKKRGDQback to top Annotated Terms
The following terms have been associated with this transcript:
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