Bestrophin homolog

Overview
NameBestrophin homolog
Smed IDSMED30020985
Length (bp)1746
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bestrophin homolog (SMED30020985) t-SNE clustered cells

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30020985) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bestrophin homolog (SMED30020985) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bestrophin homolog (SMED30020985) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020985

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30020985SMESG000055094.1 dd_Smed_v4_3859_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST1 (bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703])

HSP 1 Score: 205.297 bits (521), Expect = 7.241e-58
Identity = 129/372 (34.68%), Postives = 200/372 (53.76%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDP 1286
            M+ T ++ ++N R L     +L  W+GS+YKL++ + L ++  YY+I  IYRLAL + Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L  G + G +    L LRRT++RY NL  +L +R +S  +  RF                          P  Q+      +T AE +  E +++  +          +WVP  W + +  K+++   + DP  +  ++ E++ +R    +L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHELD  VP+FT  QF F +GWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  +V    +  P R++P
Sbjct:    1 MTITYTSQVANAR-LGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRL-LRRTLIRYANLGNVLILRSVSTAVYKRF--------------------------PSAQHLVQAGFMTPAEHKQLEKLSLPHNM---------FWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLP-RMEP 334
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 196.438 bits (498), Expect = 2.017e-56
Identity = 123/364 (33.79%), Postives = 192/364 (52.75%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEM 1265
            M+ T S+ ++N  + +    +L KW+GS+YKL++ + + +  +Y  I+L+YRL L   QK+ F K+  + D     IP  F+LGF+V+ V+ RW   ++ +PW  R  FL    ++G++    L LRRT++RY+NL  +L  R +S  +  RF           + T  R +F N  K P ++                                 YWVP  W   +  K+     + D   +  ++ E++R R+    L  +  + IPLVYTQVV +AVY+FF   L   QF+DP +   GH+LD Y+PIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+  +D NL  +  +V  E+ M
Sbjct:    1 MTVTYSSKVANA-TFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRL-LRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLF-NHLKSPHLK---------------------------------YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVD-EMHM 327
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 197.593 bits (501), Expect = 1.439e-54
Identity = 123/364 (33.79%), Postives = 192/364 (52.75%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEM 1265
            M+ T S+ ++N  + +    +L KW+GS+YKL++ + + +  +Y  I+L+YRL L   QK+ F K+  + D     IP  F+LGF+V+ V+ RW   ++ +PW  R  FL    ++G++    L LRRT++RY+NL  +L  R +S  +  RF           + T  R +F N  K P ++                                 YWVP  W   +  K+     + D   +  ++ E++R R+    L  +  + IPLVYTQVV +AVY+FF   L   QF+DP +   GH+LD Y+PIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+  +D NL  +  +V  E+ M
Sbjct:    1 MTVTYSSKVANA-TFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRL-LRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLF-NHLKSPHLK---------------------------------YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVD-EMHM 327
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 190.274 bits (482), Expect = 5.575e-53
Identity = 119/358 (33.24%), Postives = 188/358 (52.51%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R     L  +  I +PLVYTQVV IA+YS+FL  L   QF+DP +  K H+LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Human
Match: BEST2 (bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107])

HSP 1 Score: 190.274 bits (482), Expect = 5.575e-53
Identity = 119/358 (33.24%), Postives = 188/358 (52.51%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R     L  +  I +PLVYTQVV IA+YS+FL  L   QF+DP +  K H+LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSNLAAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQFLDPAQGYKDHDLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-4 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O17205])

HSP 1 Score: 178.333 bits (451), Expect = 1.026e-48
Identity = 114/362 (31.49%), Postives = 188/362 (51.93%), Query Frame = 3 
Query:  213 SLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGK-IITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGH--ELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPE-RLDP 1286
             L+  + +L +WKGS++K +W +LL ++  Y ++++IYR+ LNK Q++ F ++  F D     IP  F+LGF+VS V  RW K++  + W+   A      I G      L +RR  +RY+ +A ++  R +S  I  RF                          P I++  G  ++T+ E+  F+AI              +YW PIQW   ++  +     ++D      +I+++   R  + NL +F  + IPLVYTQVV +AV ++F+  LF  QF++    + G   ++D Y PI T  Q +F++GWLKV+  ++NP G+DDEDF+T+ I++ NL   Y  V      +P  + DP
Sbjct:   13 GLFTQIKVLLRWKGSVWKSIWSELLIWLLCYSILSVIYRILLNKAQREVFEQLCTFFDTFSVFIPVTFMLGFYVSIVYNRWTKVFDNVGWIDTSALTIAQYIRGTSEKARL-IRRNCVRYMIVAQVMVFRDVSPAIRRRF--------------------------PTIKHLIGAGLLTEDELTEFDAITSPQS---------KYWQPIQWLFSLVTVAKDEGLIADSYLYVDLIDKMREFRTKILNLVIFDMVPIPLVYTQVVNLAVRTYFVLALFGRQFLENNNNIPGAKWKIDIYFPIMTSLQIVFIVGWLKVSEVMLNPLGEDDEDFETNWIIERNLQVGYAVVDQAYGRYPTLKRDP 338
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-23 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A5JYR2])

HSP 1 Score: 173.711 bits (439), Expect = 2.637e-48
Identity = 112/334 (33.53%), Postives = 173/334 (51.80%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTT 1235
            +L +WKGSL+K +W  LL ++ +YY+IN  YR  + K Q+  F+K V   D     IP  FLLGF+V+ ++ RW     LI W     +     I G +P   + +R+TI RY  L  +L  R IS ++  R+  +              D  ++             ++T  E+  F++I +  D + K      +WVP+ W   ++ + F    ++    +  +++ L++ RN    L ++  I IPLVYTQV  I+VY +FL  L   Q+  P +      +D YVPIFTI QFLF +GWLKV   +M PFG DDEDF+ + IL+ NL+ +
Sbjct:   12 LLFRWKGSLWKAIWKHLLIFLTMYYIINAYYRFGMTKEQQNEFIKYVMLVDGWTKEIPLTFLLGFYVAMIVRRWWDCCQLISWPDHLLYNVSALIRGQDPETRI-IRKTIARYTILTSVLAWRSISLRVLARYPTD--------------DHLVD-----------SGLMTKEEMVMFKSILVHVDPHQK------WWVPLNWIQTMMVRCFEKGTLTHTNELRVLLDALEKYRNGFFQLFIYDWIAIPLVYTQVSTISVYGYFLFALIGRQY--PSKNENEEIVDVYVPIFTILQFLFYVGWLKVGEDLMFPFGADDEDFEFNYILERNLEVS 311
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-8 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O62095])

HSP 1 Score: 170.629 bits (431), Expect = 3.278e-46
Identity = 114/364 (31.32%), Postives = 184/364 (50.55%), Query Frame = 3 
Query:  192 NIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADE-MKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            N+  +  S +    +L +W+GS++K +W +L+ ++  YYL+ + YR+AL   QK    K +   D+ +   +P  F+L FFV+ ++ RW  M+  I ++   A      + G E  + L  +RTI+RYL L  +L  R IS ++  RF N                              +  II    ++  E+I +  D NG+ NY    W+P+ W+S ++QK F    +      N + +E+   R+NM  L  +  + IP+ Y QVV  AV  +F   LF  Q +D  E  K   +D+Y PI T+FQF F MGW+KVA  ++NP G+DD+DF+ + ++D N+ T    V+ +    PE L
Sbjct:    6 NLDVSSVSFFNFFKLLFRWRGSVWKSIWSELVLWLLGYYLVMVTYRVALTTEQKAGVRKYIDHLDQNLDKCVPLTFMLAFFVTIIVDRWKNMFANIGFIENTAIAIATLVKGTEGDV-LLAKRTIIRYLVLTQVLVFRDISLKVRRRFPN------------------------------HDAIIKAGFLQDHESIILGGD-NGRTNY----WMPVNWSSAILQKLFEDGNIPAAPLFNSVWQEVKTFRSNMATLCNYDWVPIPIAYPQVVFFAVRVYFFTCLFTRQHLD-MEDTK--TIDYYFPILTVFQFTFFMGWMKVAEALLNPLGEDDDDFECNYLIDRNIATGMAIVNSKYSDVPEML 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-8 (Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O62095])

HSP 1 Score: 170.629 bits (431), Expect = 3.278e-46
Identity = 114/364 (31.32%), Postives = 184/364 (50.55%), Query Frame = 3 
Query:  192 NIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADE-MKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            N+  +  S +    +L +W+GS++K +W +L+ ++  YYL+ + YR+AL   QK    K +   D+ +   +P  F+L FFV+ ++ RW  M+  I ++   A      + G E  + L  +RTI+RYL L  +L  R IS ++  RF N                              +  II    ++  E+I +  D NG+ NY    W+P+ W+S ++QK F    +      N + +E+   R+NM  L  +  + IP+ Y QVV  AV  +F   LF  Q +D  E  K   +D+Y PI T+FQF F MGW+KVA  ++NP G+DD+DF+ + ++D N+ T    V+ +    PE L
Sbjct:    6 NLDVSSVSFFNFFKLLFRWRGSVWKSIWSELVLWLLGYYLVMVTYRVALTTEQKAGVRKYIDHLDQNLDKCVPLTFMLAFFVTIIVDRWKNMFANIGFIENTAIAIATLVKGTEGDV-LLAKRTIIRYLVLTQVLVFRDISLKVRRRFPN------------------------------HDAIIKAGFLQDHESIILGGD-NGRTNY----WMPVNWSSAILQKLFEDGNIPAAPLFNSVWQEVKTFRSNMATLCNYDWVPIPIAYPQVVFFAVRVYFFTCLFTRQHLD-MEDTK--TIDYYFPILTVFQFTFFMGWMKVAEALLNPLGEDDDDFECNYLIDRNIATGMAIVNSKYSDVPEML 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Celegans
Match: best-5 (Bestrophin homolog 5 [Source:UniProtKB/Swiss-Prot;Acc:P34319])

HSP 1 Score: 159.073 bits (401), Expect = 1.535e-42
Identity = 104/359 (28.97%), Postives = 183/359 (50.97%), Query Frame = 3 
Query:  198 ISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPE 1274
            ++  +SL I V ++ KW+GSL++ V+ +L+ ++  Y L+++IYR AL ++QK  F +  ++ D   G +P  F+LGFF + +I RW+K+Y  +  +   A      + G +   + ++RR I+RY  ++  L  R I   +  RF          ++E   +                  I+   E+  F +I        K  Y  +YWV   WA  ++  +   K +      N + +E+ + R+ +  + ++  + IPL+Y Q+V +AV+++F   +F  QF    +     E+D Y+P  TI +F+F MGWLKVAM ++NPFG+D +DF  + ++D NL     SV    +  PE
Sbjct:   52 LATSKSLMI-VRMIFKWRGSLWQAVYKELIVWICAYSLVSVIYRFALTRSQKDIFERFGEYCDARMGYLPLNFVLGFFCNIIIRRWLKLYTSLGNIDNIALFVSAYVRGTD-DRARQIRRNIIRYCVISQCLVFRDIHVGVRRRF---------PTLEAVAQ----------------AGIMLPHELEKFNSI--------KSRY-QKYWVSFNWALELLNVAKTEKSIDGDNARNAIAQEISKFRSALTTVSMYDWVPIPLMYPQLVNMAVHTYFFLCIFTRQFFISADAHNKTEVDLYIPFMTIIEFIFYMGWLKVAMELLNPFGEDADDFDCNLLIDRNLAIGLTSVDDAYDQLPE 374
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0082183)

HSP 1 Score: 204.912 bits (520), Expect = 3.209e-57
Identity = 130/374 (34.76%), Postives = 203/374 (54.28%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKG-----HELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            M+ T +  ++  R     + +L +W+GS+YKLVW+DLL+++ +YY IN++YR  LN  QK+TF  +VQ+ D  +  IP  F+LGF+VS V+ RW   Y  IPW    A      ++G +    + +RRTI+RY+ L   + +  +S ++  RF    +NN        +    +N N+         K I +   +AF           +P+   ++W+PI WA+ +I ++     + D   V  +I+EL++ R     L  +  I +PLVYTQVV +AVYS+FL      Q+ D   KV G     +++D Y P+FT  QF F MGWLKVA  ++NPFG+DD+DF+ + ++D NL  +Y  V       PE L
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRM-MRRTIMRYVCLCLTMVLANVSPRVKKRFPG--LNN-------LVEAGLLNDNE---------KTIIETMNKAFP----------RPS---KHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTD--GKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELL 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0337020)

HSP 1 Score: 204.912 bits (520), Expect = 4.251e-57
Identity = 130/374 (34.76%), Postives = 203/374 (54.28%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKG-----HELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            M+ T +  ++  R     + +L +W+GS+YKLVW+DLL+++ +YY IN++YR  LN  QK+TF  +VQ+ D  +  IP  F+LGF+VS V+ RW   Y  IPW    A      ++G +    + +RRTI+RY+ L   + +  +S ++  RF    +NN        +    +N N+         K I +   +AF           +P+   ++W+PI WA+ +I ++     + D   V  +I+EL++ R     L  +  I +PLVYTQVV +AVYS+FL      Q+ D   KV G     +++D Y P+FT  QF F MGWLKVA  ++NPFG+DD+DF+ + ++D NL  +Y  V       PE L
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRM-MRRTIMRYVCLCLTMVLANVSPRVKKRFPG--LNN-------LVEAGLLNDNE---------KTIIETMNKAFP----------RPS---KHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTD--GKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELL 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0114590)

HSP 1 Score: 204.912 bits (520), Expect = 7.014e-57
Identity = 130/374 (34.76%), Postives = 203/374 (54.28%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKG-----HELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            M+ T +  ++  R     + +L +W+GS+YKLVW+DLL+++ +YY IN++YR  LN  QK+TF  +VQ+ D  +  IP  F+LGF+VS V+ RW   Y  IPW    A      ++G +    + +RRTI+RY+ L   + +  +S ++  RF    +NN        +    +N N+         K I +   +AF           +P+   ++W+PI WA+ +I ++     + D   V  +I+EL++ R     L  +  I +PLVYTQVV +AVYS+FL      Q+ D   KV G     +++D Y P+FT  QF F MGWLKVA  ++NPFG+DD+DF+ + ++D NL  +Y  V       PE L
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRM-MRRTIMRYVCLCLTMVLANVSPRVKKRFPG--LNN-------LVEAGLLNDNE---------KTIIETMNKAFP----------RPS---KHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTD--GKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELL 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best1 (gene:FBgn0040238 transcript:FBtr0306023)

HSP 1 Score: 204.912 bits (520), Expect = 8.688e-57
Identity = 130/374 (34.76%), Postives = 203/374 (54.28%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKG-----HELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERL 1280
            M+ T +  ++  R     + +L +W+GS+YKLVW+DLL+++ +YY IN++YR  LN  QK+TF  +VQ+ D  +  IP  F+LGF+VS V+ RW   Y  IPW    A      ++G +    + +RRTI+RY+ L   + +  +S ++  RF    +NN        +    +N N+         K I +   +AF           +P+   ++W+PI WA+ +I ++     + D   V  +I+EL++ R     L  +  I +PLVYTQVV +AVYS+FL      Q+ D   KV G     +++D Y P+FT  QF F MGWLKVA  ++NPFG+DD+DF+ + ++D NL  +Y  V       PE L
Sbjct:    1 MTITYTGEVATCRGFGCFLKLLLRWRGSIYKLVWLDLLAFLTIYYAINMVYRFGLNPAQKETFEAIVQYCDSYRELIPLSFVLGFYVSIVMTRWWNQYTSIPWPDPIAVFVSSNVHGQDERGRM-MRRTIMRYVCLCLTMVLANVSPRVKKRFPG--LNN-------LVEAGLLNDNE---------KTIIETMNKAFP----------RPS---KHWLPIVWAASIITRARKEGRIRDDFAVKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTCCMGQQWTD--GKVVGNTTYLNKVDLYFPVFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSYLIVDEMHHDHPELL 340
[Close]
BLAST of Bestrophin homolog vs. Ensembl Fly
Match: Best4 (gene:FBgn0036491 transcript:FBtr0113172)

HSP 1 Score: 198.364 bits (503), Expect = 3.625e-56
Identity = 122/367 (33.24%), Postives = 195/367 (53.13%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPE 1274
            M+ T ++ +S    L   + +L +W+GS+YKL+W+DL+ + G+Y L+ + YRL +N+  K+ F  ++ + ++    IP  F+LGFFV  V+ RW   Y  IPW    A L    I+G++    + +RRTILRY+ L  ++    IS ++  RF                               TY +II    +   E   I++     P+Y P++W+PI WA+ ++ ++     + D   V  +I+EL+++R N   L  +  I +PLVYTQVV +A YSFFL  +   Q+ +      G  +  + PI T+ QF F MGWLKVA  ++NPFG+DD+DF+ + I+D NL  +Y  V    +  PE
Sbjct:    1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARV-MRRTILRYVCLCQVIVFTMISPRVKRRF------------------------------PTYTQIIEAGFLLENEKKIIEAMDQAFPSY-PKHWMPIVWAASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQWNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCIVDEMHQEHPE 335
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 198.749 bits (504), Expect = 4.014e-55
Identity = 120/367 (32.70%), Postives = 199/367 (54.22%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T S  +++ R L     +L +WKGS+YKL++ +LL +  +Y +I++ YR  L + Q++ F K+  + D+    IP  F+LGF+V+ V+ RW   +  +PW  R + L  G + G +    L +RR+++RY NL+ IL  R +S  +  RF                          P + +     ++T  E+R  + +         P+   ++WVP  W   +  ++     +++   +  ++ EL+ +R+    L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH LDFY+P+FT+ QF F +GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  SV    ++ P
Sbjct:    1 MTVTYSRRVADAR-LGTFYRLLLRWKGSIYKLLYRELLIFTVMYCIISITYRCVLTEEQRRMFEKLSLYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLSALVSGHVRGADEGARL-IRRSLMRYANLSGILIYRSVSTAVYKRF--------------------------PTMSHLVQAGLMTAEELRQLQEL---------PSPHNKFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 187.193 bits (474), Expect = 8.691e-53
Identity = 125/370 (33.78%), Postives = 191/370 (51.62%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXX--XXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVS---GELEM 1265
            M+ T +  ++N R       +LA WKGS+YK+++ + L++  +Y  I++ YR  L   QK+ F K+  + D     IP  F+LG   +V+ V+ RW   Y  IP   R   +  G + G++    L LRRT++RY +L+ +L +R +S  +  RF                          P I +      +T  E + FE++   S  N       +YW+P  W + +   +     + D  T   ++EEL+  R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH+LD YVPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V    G+L M
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WKGSIYKVLYKEFLAFFAMYTAISITYRFFLVDGQKRYFEKLSIYCDNYASLIPMSFVLGMRFYVTLVVNRWWSQYTSIPLPDRVMCVLSGGVQGSDERGRL-LRRTLMRYSSLSALLILRSVSTAVFKRF--------------------------PTIDHVVEAGFMTREERKKFESL--HSPYN-------KYWIPCVWFTNLAAAARCEGRIKDDNTYKLLLEELNNFRGKCSMLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPGQGYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMYGDLPM 333
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 176.792 bits (447), Expect = 1.069e-49
Identity = 112/346 (32.37%), Postives = 181/346 (52.31%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            +L +WKGS+YKL++ + L +  +Y  I+++YR  LN  Q++ F ++ +  ++    IP  F+LGF+V+    RW   Y   P       +  G ++G +    L LRRT++RY NL+ +L +R IS ++  RF             TT+ DI                 +T  E+R    +   SD N       +YW+P+ W + +  ++     V D   +  +++EL+  R+    L  +  I IPLVYTQVV +AVYSFF   L   QF+ P    +   LD Y+PIFT+ +F F  GWLKV   ++NPFG+DD+DF+T++++D N+  +  +V    +  P
Sbjct:   20 LLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRL-LRRTLMRYANLSSVLILRSISTRVRKRF-------------TTLEDI------------VEAGFMTTDELRKLNHLY--SDFN-------KYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEE--HLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLP 328
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 174.866 bits (442), Expect = 2.382e-49
Identity = 110/331 (33.23%), Postives = 176/331 (53.17%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNL 1226
            +L +WKGS+YKL++ + L +  +Y  I+++YR  LN  Q++ F ++ +  ++    IP  F+LGF+V+    RW   Y   P       +  G ++G +    L LRRT++RY NL+ +L +R IS ++  RF             TT+ DI                 +T  E+R    +   SD N       +YW+P+ W + +  ++     V D   +  +++EL+  R+    L  +  I IPLVYTQVV +AVYSFF   L   QF+ P    +   LD Y+PIFT+ +F F  GWLKV   ++NPFG+DD+DF+T++++D N+
Sbjct:   20 LLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFARLARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRL-LRRTLMRYANLSSVLILRSISTRVRKRF-------------TTLEDI------------VEAGFMTTDELRKLNHLY--SDFN-------KYWMPLAWFANLASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQFVKPASSEE--HLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNI 313
[Close]
BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 133.265 bits (334), Expect = 3.097e-34
Identity = 62/151 (41.06%), Postives = 96/151 (63.58%), Query Frame = 3 
Query:  819 EYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            ++WVP  W   +  ++     +++   +  ++ EL+ +R+    L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH LDFY+P+FT+ QF F +GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  SV    ++ P
Sbjct:   20 KFWVPCMWFVSLAMRARSEGRINNDVAMTAILNELNTLRSQCMRLYGYDWISLPLVYTQVVTVAVYSFFLTCLIGRQFLDPAQGYPGHNLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 170
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 197.208 bits (500), Expect = 6.922e-57
Identity = 118/359 (32.87%), Postives = 192/359 (53.48%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T SN +++ R L     +L +W+GS+YKL++ + L ++  Y++I++ YR  LN+ Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    + LRRT++RY NL  +L +R +S  + +RF                          P +Q+      +T  E   F+ +    +         ++WVP  W + +   +     + D   +  +++EL+ +R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP++   GH++D YVP+FT+ QF F  GWLKVA  ++NPFG DD+DF+T+ ++D NL  +  +V
Sbjct:    1 MTVTYSNRVADAR-LGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRM-LRRTLMRYANLTGLLILRSVSTAVYMRF--------------------------PTLQHVVNAGFMTPTERSKFDGLVSSHN---------KFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 196.438 bits (498), Expect = 1.290e-56
Identity = 118/359 (32.87%), Postives = 192/359 (53.48%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T SN +++ R L     +L +W+GS+YKL++ + L ++  Y++I++ YR  LN+ Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    + LRRT++RY NL  +L +R +S  + +RF                          P +Q+      +T  E   F+ +    +         ++WVP  W + +   +     + D   +  +++EL+ +R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP++   GH++D YVP+FT+ QF F  GWLKVA  ++NPFG DD+DF+T+ ++D NL  +  +V
Sbjct:    1 MTVTYSNRVADAR-LGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRM-LRRTLMRYANLTGLLILRSVSTAVYMRF--------------------------PTLQHVVNAGFMTPTERSKFDGLVSSHN---------KFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 197.208 bits (500), Expect = 3.365e-56
Identity = 118/359 (32.87%), Postives = 192/359 (53.48%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T SN +++ R L     +L +W+GS+YKL++ + L ++  Y++I++ YR  LN+ Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    + LRRT++RY NL  +L +R +S  + +RF                          P +Q+      +T  E   F+ +    +         ++WVP  W + +   +     + D   +  +++EL+ +R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP++   GH++D YVP+FT+ QF F  GWLKVA  ++NPFG DD+DF+T+ ++D NL  +  +V
Sbjct:    1 MTVTYSNRVADAR-LGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRM-LRRTLMRYANLTGLLILRSVSTAVYMRF--------------------------PTLQHVVNAGFMTPTERSKFDGLVSSHN---------KFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 196.438 bits (498), Expect = 3.663e-56
Identity = 118/359 (32.87%), Postives = 192/359 (53.48%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T SN +++ R L     +L +W+GS+YKL++ + L ++  Y++I++ YR  LN+ Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    + LRRT++RY NL  +L +R +S  + +RF                          P +Q+      +T  E   F+ +    +         ++WVP  W + +   +     + D   +  +++EL+ +R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP++   GH++D YVP+FT+ QF F  GWLKVA  ++NPFG DD+DF+T+ ++D NL  +  +V
Sbjct:    1 MTVTYSNRVADAR-LGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRM-LRRTLMRYANLTGLLILRSVSTAVYMRF--------------------------PTLQHVVNAGFMTPTERSKFDGLVSSHN---------KFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:NCBI gene;Acc:100302038])

HSP 1 Score: 197.978 bits (502), Expect = 4.605e-55
Identity = 118/359 (32.87%), Postives = 192/359 (53.48%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T SN +++ R L     +L +W+GS+YKL++ + L ++  Y++I++ YR  LN+ Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    + LRRT++RY NL  +L +R +S  + +RF                          P +Q+      +T  E   F+ +    +         ++WVP  W + +   +     + D   +  +++EL+ +R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP++   GH++D YVP+FT+ QF F  GWLKVA  ++NPFG DD+DF+T+ ++D NL  +  +V
Sbjct:    1 MTVTYSNRVADAR-LGTFSRLLLRWRGSIYKLLYREFLIFISCYFIISVTYRFLLNEQQRIYFEKLALYCDNYAELIPVSFVLGFYVTLVVSRWWGQYESVPWPDRLMCLVSSNVHGTDERGRM-LRRTLMRYANLTGLLILRSVSTAVYMRF--------------------------PTLQHVVNAGFMTPTERSKFDGLVSSHN---------KFWVPCVWFANLAVTARSEGRIRDNVVLQLILKELNSLRTQCGRLYGYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPQKGYPGHDMDLYVPVFTLLQFFFYAGWLKVAEQLINPFGQDDDDFETNWLIDRNLQVSLLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 195.667 bits (496), Expect = 4.899e-56
Identity = 123/367 (33.51%), Postives = 192/367 (52.32%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T +N ++N R L    ++L  W+GS+YKL++ + L ++ +YY I  +YR+ L+  Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R        + G +    L LRRT++RY  L  +L +R IS  +  RF                          P + +      +T  E +  + + +  ++         +WVP  W + +  K+++   + D   +  ++ E+  +R     L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHE+D  VP+FTI QFLF MGWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  SV G  +  P
Sbjct:    1 MTITYTNKVANAR-LGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRL-LRRTLIRYAILGQVLILRSISTSVYKRF--------------------------PTLHHLVLAGFMTHGEHKQLQKLGLPHNT---------FWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best1 (bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332])

HSP 1 Score: 197.208 bits (500), Expect = 1.988e-55
Identity = 123/366 (33.61%), Postives = 193/366 (52.73%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T +N ++N R L    ++L  W+GS+YKL++ + L ++ +YY I  +YR+ L+  Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R        + G +    L LRRT++RY  L  +L +R IS  +  RF              T+  + +               +T  E +  + + +  ++         +WVP  W + +  K+++   + D   +  ++ E+  +R     L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHE+D  VP+FTI QFLF MGWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  SV G  +  P
Sbjct:    1 MTITYTNKVANAR-LGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRL-LRRTLIRYAILGQVLILRSISTSVYKRF-------------PTLHHLVL------------AGFMTHGEHKQLQKLGLPHNT---------FWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 190.66 bits (483), Expect = 2.143e-53
Identity = 121/358 (33.80%), Postives = 189/358 (52.79%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G+Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R+    L  +  I IPLVYTQVV IAVYS+FL  L   QF+DP +  K H LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 190.66 bits (483), Expect = 2.143e-53
Identity = 121/358 (33.80%), Postives = 189/358 (52.79%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G+Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R+    L  +  I IPLVYTQVV IAVYS+FL  L   QF+DP +  K H LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. Ensembl Mouse
Match: Best2 (bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588])

HSP 1 Score: 190.66 bits (483), Expect = 2.143e-53
Identity = 121/358 (33.80%), Postives = 189/358 (52.79%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G+Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R+    L  +  I IPLVYTQVV IAVYS+FL  L   QF+DP +  K H LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|O76090|BEST1_HUMAN (Bestrophin-1 OS=Homo sapiens OX=9606 GN=BEST1 PE=1 SV=1)

HSP 1 Score: 205.297 bits (521), Expect = 3.477e-57
Identity = 129/372 (34.68%), Postives = 200/372 (53.76%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDP 1286
            M+ T ++ ++N R L     +L  W+GS+YKL++ + L ++  YY+I  IYRLAL + Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L  G + G +    L LRRT++RY NL  +L +R +S  +  RF                          P  Q+      +T AE +  E +++  +          +WVP  W + +  K+++   + DP  +  ++ E++ +R    +L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHELD  VP+FT  QF F +GWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  +V    +  P R++P
Sbjct:    1 MTITYTSQVANAR-LGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRL-LRRTLIRYANLGNVLILRSVSTAVYKRF--------------------------PSAQHLVQAGFMTPAEHKQLEKLSLPHNM---------FWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLP-RMEP 334
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q6UY87|BEST1_MACFA (Bestrophin-1 OS=Macaca fascicularis OX=9541 GN=BEST1 PE=2 SV=1)

HSP 1 Score: 204.142 bits (518), Expect = 9.440e-57
Identity = 128/372 (34.41%), Postives = 199/372 (53.49%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDP 1286
            M+ T ++ ++N R L     +L  W+GS+YKL++ +   ++  YY+I  IYRLAL + Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R   L  G + G +    L LRRT++RY NL  +L +R +S  +  RF                          P  Q+      +T AE +  E +++  +          +WVP  W + +  K+++   + DP  +  ++ E++ +R    +L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHELD  VP+FT  QF F +GWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  +V    +  P R++P
Sbjct:    1 MTITYTSQVANAR-LGSFSRLLLCWRGSIYKLLYGEFFIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRL-LRRTLIRYANLGNVLILRSVSTAVYKRF--------------------------PSAQHLVQAGFMTPAEHKQLEKLSLPHNM---------FWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLP-RMEP 334
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|O88870|BEST1_MOUSE (Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=2 SV=3)

HSP 1 Score: 197.208 bits (500), Expect = 1.391e-54
Identity = 123/366 (33.61%), Postives = 193/366 (52.73%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T +N ++N R L    ++L  W+GS+YKL++ + L ++ +YY I  +YR+ L+  Q+  F K+  + D     IP  F+LGF+V+ V+ RW   Y  +PW  R        + G +    L LRRT++RY  L  +L +R IS  +  RF              T+  + +               +T  E +  + + +  ++         +WVP  W + +  K+++   + D   +  ++ E+  +R     L  +  I IPLVYTQVV +AVYSFFL  L   QF++P +   GHE+D  VP+FTI QFLF MGWLKVA  ++NPFG+DD+DF+T+ I+D NL  +  SV G  +  P
Sbjct:    1 MTITYTNKVANAR-LGSFSSLLLCWRGSIYKLLYGEFLVFIFLYYSIRGLYRMVLSSDQQLLFEKLALYCDSYIQLIPISFVLGFYVTLVVSRWWSQYENLPWPDRLMIQVSSFVEGKDEEGRL-LRRTLIRYAILGQVLILRSISTSVYKRF-------------PTLHHLVL------------AGFMTHGEHKQLQKLGLPHNT---------FWVPWVWFANLSMKAYLGGRIRDTVLLQSLMNEVCTLRTQCGQLYAYDWISIPLVYTQVVTVAVYSFFLACLIGRQFLNPNKDYPGHEMDLVVPVFTILQFLFYMGWLKVAEQLINPFGEDDDDFETNWIIDRNLQVSLLSVDGMHQNLP 330
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8N1M1|BEST3_HUMAN (Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1 SV=1)

HSP 1 Score: 197.593 bits (501), Expect = 6.911e-54
Identity = 123/364 (33.79%), Postives = 192/364 (52.75%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEM 1265
            M+ T S+ ++N  + +    +L KW+GS+YKL++ + + +  +Y  I+L+YRL L   QK+ F K+  + D     IP  F+LGF+V+ V+ RW   ++ +PW  R  FL    ++G++    L LRRT++RY+NL  +L  R +S  +  RF           + T  R +F N  K P ++                                 YWVP  W   +  K+     + D   +  ++ E++R R+    L  +  + IPLVYTQVV +AVY+FF   L   QF+DP +   GH+LD Y+PIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+  +D NL  +  +V  E+ M
Sbjct:    1 MTVTYSSKVANA-TFFGFHRLLLKWRGSIYKLLYREFIVFAVLYTAISLVYRLLLTGVQKRYFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFVNLPWPDRLMFLISSSVHGSDEHGRL-LRRTLMRYVNLTSLLIFRSVSTAVYKRFPTMDHVVEAGFMTTDERKLF-NHLKSPHLK---------------------------------YWVPFIWFGNLATKARNEGRIRDSVDLQSLMTEMNRYRSWCSLLFGYDWVGIPLVYTQVVTLAVYTFFFACLIGRQFLDPTKGYAGHDLDLYIPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWCIDRNLQVSLLAVD-EMHM 327
[Close]
BLAST of Bestrophin homolog vs. UniProt/SwissProt
Match: sp|Q8BGM5|BEST2_MOUSE (Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=2 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 2.077e-52
Identity = 121/358 (33.80%), Postives = 189/358 (52.79%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +L  W+GS+YKL+W +LL ++G+Y  ++  YR  L + QK+ F K+V + D+    IP  F+LGF+V+ V+ RW   YL +P       +  G ++G +    L  RRT++RY  L+ +L +R +S  +  RF          +++  +   F+   +  K +N                  + S  N       +YWVP  W S +  ++     + D   +  ++EEL+  R+    L  +  I IPLVYTQVV IAVYS+FL  L   QF+DP +  K H LD  VPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRL-YRRTLMRYAGLSAVLILRSVSTAVFKRF---------PTIDHVVEAGFMTREERKKFEN------------------LNSSYN-------KYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAV 322
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A4E0S046 (Bestrophin homolog OS=Fasciola hepatica OX=6192 GN=D915_000581 PE=3 SV=1)

HSP 1 Score: 320.087 bits (819), Expect = 6.771e-99
Identity = 173/422 (41.00%), Postives = 252/422 (59.72%), Query Frame = 3 
Query:  198 ISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMR----QISDQISL---------------------------------RFRNNKINNST-----------------NSVETT----IRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPP 1289
            IS+G +L +   +L KWKGSLYKLVW +LL Y+ +YY ++  YR AL + QK+ F ++V + D  K NIP  FLLGFFVSG++GRW  ++  IPW++R A     C+N  +   S ++R T++RY+NLAWIL +R    Q S++ S+                                 R R+  +N+ +                 N+ E      + DI  +FN D +++NT+G IIT  EI AF++IA    +  K +Y PEYWVPIQWA R+  K+   +Y+++PR    +I +L++ R+ +Q LQ+F  +M+PL Y QVV IAVY++F C+LF+SQF++ R  V    +D YVP+F    +LFLMGW KVA+CV+NPFGDDDEDFQ  +ILD NL+T++RSV  + + FP+    P
Sbjct:    9 ISDGDNLTVTCKLLRKWKGSLYKLVWSNLLIYVCLYYTLSFTYRFALTENQKRLFEQLVDYCDHAKENIPISFLLGFFVSGIVGRWFFIFPCIPWMNRVALDIASCVNAKDEVSSRKIRITLMRYVNLAWILLLRLMSDQTSNRFSVQSQTPKSRRSHHHLYHPWSIAEDEEDEKRVKTHRNRSGTLNSPSPSSPSSPYMEAESFTQFNAFEAADDKLLMDILKSFNNDERVKNTFGVIITKDEINAFQSIASDWYTRTKTHYTPEYWVPIQWAQRLTIKALQSEYITEPRRAYHLIYQLNKFRDQLQYLQIFSSMMVPLAYAQVVTIAVYTYFTCQLFSSQFVERRNGVLHSGIDLYVPVFDFLSYLFLMGWYKVALCVINPFGDDDEDFQIGDILDYNLETSFRSVYMDPQSFPKTFSAP 430
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267F2G9 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000907g1 PE=3 SV=1)

HSP 1 Score: 312.768 bits (800), Expect = 1.086e-97
Identity = 177/400 (44.25%), Postives = 254/400 (63.50%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAM--SLRLRRTILRYLNLAWILQMRQISDQISLRFRNNK---INNSTNSV--ETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKV---------------------KGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPP 1289
            M+ + S  IS+ +   + + IL  WKGSLYKL++ DL+ Y+ +YY  N+IYR  +    +++F  +V+F +EM  +IP  F+LGFFV+GVIGRW +MYL IPWL+R +F   G + G + +   + RLR +I+RY+NL WIL M  IS+QI  RF   +     + +N V  E  +R +  N NK P+++  + K++T+AEI AF     +  +  +  YVPEYW+P+QWA+ + +K+ +H +  DPR++  M+EE++ VR  MQ L ++  +MIPLVYTQVVIIAVYSFFL +LF+ QF++P+                         G  +D Y P+FT+FQF+FLMGWLKVAMCVMNPFGDDDEDF TSEIL+ NL+ + R   G+   FP     P
Sbjct:    1 MTVSYSETISSSQG-GVFIKILLLWKGSLYKLLYTDLIVYLIMYYAFNIIYRACMGPEARQSFELVVKFCEEMDKSIPLSFILGFFVAGVIGRWWQMYLNIPWLNRISFFAYGILTGTKDSFETARRLRLSIMRYMNLGWILLMHSISEQIMHRFSGQEEEEPQSKSNLVQEERGVRGLLENINKCPEVKLHFRKLVTEAEIEAFVRAEGEYKNKYQKKYVPEYWLPLQWAALLCKKAMMHGFC-DPRSMVMMMEEIEEVRGTMQTLVIYNDVMIPLVYTQVVIIAVYSFFLLQLFSQQFVNPKLTADLLSAERNVTVTPISIGNKDNHGEVIDMYFPVFTVFQFMFLMGWLKVAMCVMNPFGDDDEDFHTSEILNYNLEISSRCAEGQAITFPRACPSP 398
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A267FNT5 (Bestrophin homolog OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig025133g2 PE=3 SV=1)

HSP 1 Score: 313.923 bits (803), Expect = 4.174e-97
Identity = 174/400 (43.50%), Postives = 248/400 (62.00%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSL--RLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPR---------------------EKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGE-LEMFPERLDPPKMNY 1301
            M+   S  IS+ +   + + IL  WKGSLYKLV+ DL++Y+ +YY+ N+ YR+ +    ++ F  +V+F   M  NIP  F+LGFFV+GVIGRW +MY+ IPWL+R AF   G I G +    +  ++R +++RY+NLAWIL M  IS++I  RF N +   +       +R +  N N+  K+Q  + K++T+ EI AF     +     +  YVP+YW+P+ WA+ + +K+ IH Y  DPR++  ++ E++RVR  M  L ++  +MIPLVYTQVVIIAVYS+FL +LF+ QF++P+                         G  +D Y PIFT+ QFLFLMGWLKVAMCVMNPFGDDDEDF TS+ILD NL+ T R V G+    +PE L  P M +
Sbjct:    1 MTVAYSETISSSQG-GVFIKILLLWKGSLYKLVYTDLIAYLLIYYVFNISYRVLMPPETRQNFELVVRFCSGMDKNIPLSFILGFFVAGVIGRWWEMYMNIPWLNRIAFCCYGLITGTKDTFEVAKQIRCSLMRYMNLAWILLMHSISERIVHRFSNTE--EAAADENGGVRALLENINRCDKVQLHFRKLVTENEIDAFARAEAEYKIKYQKKYVPDYWLPLHWAALLSKKAMIHGYC-DPRSMVMIMREVERVRCMMHTLNIYNDVMIPLVYTQVVIIAVYSYFLLQLFSQQFVNPKLTAEMMSARTNATVMPVTVTSSSSTGDVIDMYFPIFTVLQFLFLMGWLKVAMCVMNPFGDDDEDFHTSDILDYNLEITSRCVEGQSAPHYPEGLTEPSMEW 396
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: A0A1I8HMQ9 (Bestrophin homolog OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 313.923 bits (803), Expect = 6.431e-97
Identity = 174/400 (43.50%), Postives = 248/400 (62.00%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSL--RLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPR---------------------EKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGE-LEMFPERLDPPKMNY 1301
            M+   S  IS+ +   + + IL  WKGSLYKLV+ DL++Y+ +YY+ N+ YR+ +    ++ F  +V+F   M  NIP  F+LGFFV+GVIGRW +MY+ IPWL+R AF   G I G +    +  ++R +++RY+NLAWIL M  IS++I  RF N +   +       +R +  N N+  K+Q  + K++T+ EI AF     +     +  YVP+YW+P+ WA+ + +K+ IH Y  DPR++  ++ E++RVR  M  L ++  +MIPLVYTQVVIIAVYS+FL +LF+ QF++P+                         G  +D Y PIFT+ QFLFLMGWLKVAMCVMNPFGDDDEDF TS+ILD NL+ T R V G+    +PE L  P M +
Sbjct:   15 MTVAYSETISSSQG-GVFIKILLLWKGSLYKLVYTDLIAYLLIYYVFNISYRVLMPPETRQNFELVVRFCSGMDKNIPLSFILGFFVAGVIGRWWEMYMNIPWLNRIAFCCYGLITGTKDTFEVAKQIRCSLMRYMNLAWILLMHSISERIVHRFSNTE--EAAADENGGVRALLENINRCDKVQLHFRKLVTENEIDAFARAEAEYKIKYQKKYVPDYWLPLHWAALLSKKAMIHGYC-DPRSMVMIMREVERVRCMMHTLNIYNDVMIPLVYTQVVIIAVYSYFLLQLFSQQFVNPKLTAEMMSARTNATVMPVTVTSSSSTGDVIDMYFPIFTVLQFLFLMGWLKVAMCVMNPFGDDDEDFHTSDILDYNLEITSRCVEGQSAPHYPEGLTEPSMEW 410
[Close]
BLAST of Bestrophin homolog vs. TrEMBL
Match: W6UHI3 (Bestrophin homolog OS=Echinococcus granulosus OX=6210 GN=EGR_07628 PE=3 SV=1)

HSP 1 Score: 312.383 bits (799), Expect = 3.975e-96
Identity = 183/480 (38.12%), Postives = 275/480 (57.29%), Query Frame = 3 
Query:  228 VTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMR----QISDQISL-----------RFRNNK------------------------------------------------INNSTNSV-----ETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFXXXXXXXXXXXXCTSETNEVKTLEMKDSIPKKIINYFKSK 1463
            + +L +WKGSLYKLVW+DLL Y+ ++Y + LIY + LN +Q+  F ++V + +E++G +P  FLLGFFVSGVIGRW   Y+ IPWL+  ++     IN  +P ++LR R T++R+LNL+WIL MR    +IS++  +           R R+N+                                                 NN  NS+     +  +R+   + N D K+Q T+GK+IT+ EIRAFEAI  +     +  Y+PEYWVP+QWA RV+QK+ +H  + DP+ +  ++ EL + R  +Q L+ F  + +PLVYTQV +IAVYS+F+C++ A+Q+ +             VP+F++F F+FL+GWLKVA+CVM+PFGDD EDF+TSEILD NLD +YR V  +   +PE L         +   E D+L TFLD +  DL+D++     N++  LE++     ++   F SK
Sbjct:    6 IILLNRWKGSLYKLVWLDLLGYLFLHYFVQLIYWVFLNHSQRIAFNEVVDYCEEIRGQVPISFLLGFFVSGVIGRWFDTYMYIPWLNNISYQIAATINCADPRVALRARLTVMRHLNLSWILMMRTISDRISNRFRMQCTATEGHKRQRLRHNRHDIFRSSEWPDEKLKKSHSRKRGSSPLTATSPLQAQTKPSPTASGVFSFNNPDNSLFDAPDDYGLRETLKSINNDKKVQQTFGKLITEPEIRAFEAIGRRYFQKTRQRYLPEYWVPLQWAVRVVQKTALHGNIPDPKILITVLNELGKFRERLQLLKTFSSLTMPLVYTQVAVIAVYSYFICQILATQYTERAVNETNINASMPVPLFSVFYFIFLVGWLKVALCVMSPFGDDYEDFETSEILDYNLDVSYRVVLMDEATYPEDLKRATFALRTMDGCENDSLRTFLDSVSRDLDDVEFDENANDIHNLEVRPDFLNQLKERFCSK 485
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 196.438 bits (498), Expect = 3.888e-54
Identity = 121/367 (32.97%), Postives = 200/367 (54.50%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T S  +++ R L     +L +WKGS+YKL++ +LL +  +Y  I+++YR  L+  Q++ F K+  + D+    IP  F+LGF+V+ V+ RW   +  +PW  R A L    + G +    L +RR+++RY NL+ +L  R IS  +  RF                          P I++     ++T  E R  + +         P+   ++WVP  W   +  ++     +++   ++ ++ EL+ +R+    L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH+LDFY+P+FT+ QF F +GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  SV    ++ P
Sbjct:    1 MTVTYSRRVADAR-LGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARL-IRRSLVRYANLSGVLIYRSISTAVYKRF--------------------------PTIEHLVQAGLMTVEERRQLDDL---------PSPHNKFWVPCMWFVNLALRARTEGRINNDVALSAILNELNTLRSQCMKLYSYDWISLPLVYTQVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 185.267 bits (469), Expect = 1.718e-50
Identity = 122/367 (33.24%), Postives = 194/367 (52.86%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVS---GELEM 1265
            M+ T +  ++N R       +LA W+GS+YK+++ ++L++  +Y  I++ YR  L   QK+ F K+  + +     IP  F+LGF+V+ ++ RW   Y  IP       +  G + G +    L LRRT++RY +LA +L +R +S  +  RF          +++  +   F+                T  E + FE++   S  N       +YW+P  W + +   +     + D  T   ++EEL++ R     L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH+LD YVPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V    G+L M
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WRGSIYKVLYKEVLAFFILYTAISITYRFFLLDEQKRYFEKLSIYCNHYASLIPMSFVLGFYVTLIVNRWWSQYTSIPLPDSIMCVLSGGLQGGDERGRL-LRRTLMRYASLASLLILRSVSTAVFKRF---------PTMDHVVEAGFM----------------TREERKKFESL--HSPYN-------KYWIPCVWFTNLAAVARSEGRIKDDNTYKLLLEELNKFRGKCSLLFHYDMISVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQAYPGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAVDEMFGDLPM 331
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best4 (bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6])

HSP 1 Score: 168.318 bits (425), Expect = 1.219e-46
Identity = 110/349 (31.52%), Postives = 180/349 (51.58%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQ-VVIIAVYSFFLCELFASQFIDPR--EKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            +L +WKGS+YKL++ + L +  +Y L +LIYR  L   Q++ F +  +  ++    IP  F+L +       RW   Y   P       +  G ++G++    L LRRT++RY NL+ +L +R IS ++  RF                          P +Q+     +T+ E+R  + +   SD N       +YW+P+ W + +  K+     V D   +  +++EL+  R     L  +  I IPLVYTQ VV +AVYSFF   L   QF+ P   +++K H +D YVP+FT+ +F F  GWLKV   ++NPFG+DD+DF+T++++D N+  +  +V    +  P
Sbjct:   20 LLFRWKGSIYKLLYKEFLLFCFLYSLFSLIYRCVLTDGQQELFERAARHCNKFAKLIPMSFVLFYVTQA-FQRWWGQYTSFPLPDNLMMVVSGNVHGSDERGRL-LRRTLMRYANLSSVLILRSISTRVHKRF--------------------------PTLQHIVDAFMTEEEMRTLDHLY--SDFN-------KYWMPLTWFANLASKAREEGRVKDDIALRLLMDELNNYRGKCSMLFHYDWISIPLVYTQQVVTLAVYSFFAFCLIGRQFVKPERADELKVH-VDLYVPVFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLAVDDMHQNLP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:103045999])

HSP 1 Score: 166.007 bits (419), Expect = 1.887e-43
Identity = 113/367 (30.79%), Postives = 182/367 (49.59%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQN-TYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T S  +++ R L     +L +WKGS+YKL++ +LL +  +Y  I+++YR  L+  Q++ F K+  + D+    IP  F+LGF+V+ V+ RW   +  +PW  R A L    + G +    L +RR+++RY NL+ +L  R IS  +  RF                          P I++     ++T  E R  + +         P+   ++WVP  W   +  ++                    R    + N      I+       VV +AVYSFFL  L   QF+DP +   GH+LDFY+P+FT+ QF F +GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  SV    ++ P
Sbjct:    1 MTVTYSRRVADAR-LGTFSHLLLRWKGSIYKLLYRELLIFTVLYCTISVLYRFLLDNEQRRLFEKLAIYCDQYAQLIPVSFVLGFYVTLVVSRWWGQFESVPWPDRLAALVGAYVRGADEGARL-IRRSLVRYANLSGVLIYRSISTAVYKRF--------------------------PTIEHLVQAGLMTVEERRQLDDL---------PSPHNKFWVPCMWFVNLALRA--------------------RTEGRINNDVALSAIL------NVVTVAVYSFFLACLIGRQFLDPTQGYSGHDLDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWLVDRNLQVSLLSVDEMYDLVP 304
[Close]
BLAST of Bestrophin homolog vs. Ensembl Cavefish
Match: BEST3 (bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105])

HSP 1 Score: 129.413 bits (324), Expect = 6.072e-32
Identity = 71/201 (35.32%), Postives = 107/201 (53.23%), Query Frame = 3 
Query:  729 YGKIITDAEIRAFEAIAIKSDSNGKPNYV--------PE--------------YWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEM 1265
            Y  ++TD + R FE ++I  D   +   V        PE              YW+P  W + +  K+     + D   +  ++ E++R R     L  +  + IPLVYTQVV +AVY+FF   +   QF+DP +   GH+LD YVP+FT+ QF F  GWLKVA  ++NPFG+DD+DF+ +  +D NL  +  +V  E+ M
Sbjct:   50 YRWVLTDPQRRLFEKLSIYCDRYAEQIPVTFVLGFMTPEEKKIFENLKSPHLKYWIPTVWFTNLASKARKDGRIQDSVDLQTILTEMNRFRTWCSTLFGYDWVGIPLVYTQVVTLAVYTFFSASIIGRQFLDPAQGYPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWCIDRNLQVSLMAVD-EMHM 249

HSP 2 Score: 49.2914 bits (116), Expect = 9.517e-6
Identity = 23/78 (29.49%), Postives = 46/78 (58.97%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIP 407
            M+ T S+ ++N  + +    +L +W+GS+YKL++ + L +  +Y +++L+YR  L   Q++ F K+  + D     IP
Sbjct:    1 MTVTYSSKVANA-TFFGFHRLLLRWRGSIYKLLYREFLFFALLYSILSLVYRWVLTDPQRRLFEKLSIYCDRYAEQIP 77
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best2 (bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127])

HSP 1 Score: 190.274 bits (482), Expect = 6.737e-54
Identity = 118/367 (32.15%), Postives = 189/367 (51.50%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            M+ T +N ++N R L     +L +W+GS+YKL++ +   Y  +Y  ++L  R AL++ QK+ F K+  + +     IP     GF+V+ V+ RW   Y  IP   R      G ++G +    L LRRT++RY NL+ +L +R +S  +  RF                          P + +      +T  E + F+ +    +         +YWVP  W S +  ++     V D   +  +++E++  R N   L  +  I +PLVYTQVV +AVYSFFL  L   QF+DP +   GH++D Y+P+FT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  +V    +  P
Sbjct:    1 MTVTYTNRVANAR-LCGFSKLLLQWRGSIYKLLYREFSIYFMMYAALSLTSRFALSEDQKRLFEKLSLYCNNYANLIPVRSCSGFYVALVVSRWWSQYTSIPTPDRLMCAVAGTVHGVDERGRL-LRRTLMRYANLSALLILRSVSTAVYKRF--------------------------PTMDHVVEAGFMTRDERKRFDGLRCSYN---------KYWVPCVWLSSLAAQARAEGRVRDDVALKLLLDEMNVYRGNCGMLFHYDWISVPLVYTQVVTVAVYSFFLACLIGRQFLDPAQGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNLQVSMLAVDEMYQNLP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Match: best1 (bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214])

HSP 1 Score: 181.8 bits (460), Expect = 2.936e-52
Identity = 122/373 (32.71%), Postives = 199/373 (53.35%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPP 1289
            M+ T SN ++N R L     +L +WKGS+YKL++ +   ++ +++ ++ +YR  L + QK+ F K+  + ++    IP  F+LGF+V+ V+ RW   Y  +PW  R   L    ++G +    L LRRT++RY NL+ +L +R +S  +  RF                          P + +      +T AE R F+ +  +S  N       ++WVP  W + +  ++     + D  ++  ++ +L+  R+    L  +  + IPLVYTQVV +AVYSFFL  L   QF+ P +   GH++D Y+P+FT+ QF F  GWLKVA  ++NPFG+DD+DF+ +  +D NL     S+ G  EM+  R  PP
Sbjct:    1 MTVTYSNKVANAR-LGGFSQLLLRWKGSIYKLLYKEFCIFLVLFFTLSSVYRYMLQENQKRYFEKLAMYCNKYAELIPVSFVLGFYVTLVVSRWWSQYESLPWPDRLMHLVACNVHGADERGRL-LRRTLMRYANLSALLILRSVSTAVYKRF--------------------------PTMDHVVEAGFMTPAERRKFDGL--RSPHN-------KFWVPCVWFANLAAQAKAEGRILDNVSLQLILNDLNNFRSCCSMLYSYDWVSIPLVYTQVVTVAVYSFFLACLIGRQFLGP-QGYPGHDMDLYIPVFTLLQFFFYAGWLKVAEQLINPFGEDDDDFEANWCVDRNLQV---SLMGVDEMY--RDLPP 330
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: BEST3 (bestrophin 3 [Source:NCBI gene;Acc:101172121])

HSP 1 Score: 200.675 bits (509), Expect = 4.342e-56
Identity = 125/365 (34.25%), Postives = 196/365 (53.70%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTY-GKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEM 1265
            M+ T S+ ++N   L     +L +W+GS+YKL++ + L +  +Y +++LIYRLAL++ QK+ F K+  + D     IP  F+LGF+V+ V+ RW   +L +PW  R  F    C+ G +    L LRRT++RY+NL  +L  R +S  +  RF                          P I +      +T  E + FE I         P+   +YW+P+ W S +  ++     + D   +  ++ E++  R     L  +  + IPLVYTQVV +AVY+FF   +   QF+DP +   GH+LD YVP+FT+ QF F  GWLKVA  ++NPFG+DD+DF+ + I+D NL  +  +V  E+ M
Sbjct:    1 MTVTYSSKVANATFLSFH-RLLLRWRGSIYKLLYREFLLFALLYTILSLIYRLALSEQQKRLFEKLSIYCDRYAEQIPVTFVLGFYVTLVVNRWWNQFLNLPWPDRLMFHISSCVQGKDEYGRL-LRRTLVRYINLTSLLIFRSVSTAVCKRF--------------------------PTIDHVVEAGFMTPEERKVFENIR-------SPHL--KYWIPVVWFSNLASRARQEGRIQDAIDLQNILNEMNTFRTWCATLFGYDWVGIPLVYTQVVTLAVYTFFFACIIGRQFLDPAQGHPGHDLDLYVPVFTLLQFFFYSGWLKVAEQLINPFGEDDDDFEANWIIDRNLQVSLLAVD-EMHM 327
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best1 (bestrophin-2 [Source:NCBI gene;Acc:101167866])

HSP 1 Score: 192.2 bits (487), Expect = 1.121e-52
Identity = 110/346 (31.79%), Postives = 183/346 (52.89%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFP 1271
            +L +WKGS+YKL++ +L+ +  +YY ++L+Y + L+  Q++ F ++  + D     IP  F+L +     + RW   +  IPW  R A L  G + G + A  L  RR ++RY+NL+ +L  R +S  +  RF                          P  ++    ++T  E+R FE +    +         ++WVP  W   +  ++     +++   +  ++ EL+ +R     L  +  I +PLVYTQV  +AVYSFFL  L   QF+DP +   GH++DFY+P+FT+ QF F +GWLKVA  ++NPFG+DD+DF+T+ ++D NL  +  SV    +  P
Sbjct:   20 LLLRWKGSIYKLLYRELIIFTLLYYFLSLVYYM-LDNDQRRLFERLSIYCDRYAELIPVSFVLFYVTLV-VSRWWGQFENIPWPDRLAALVGGHVRGTDEASRL-TRRALMRYVNLSGVLIYRSVSTAVYKRF--------------------------PTTEHLVQALMTSEELRHFEELPSPHN---------KFWVPCMWFVNLALRARTEGRINNDVALTAILTELNSLRAKCMKLYGYDWISLPLVYTQVATVAVYSFFLACLIGRQFLDPAQGYPGHDVDFYLPVFTLLQFFFYVGWLKVAEQLINPFGEDDDDFETNWVVDRNLQVSLLSVDEMYDSLP 327
[Close]
BLAST of Bestrophin homolog vs. Ensembl Medaka
Match: best2 (bestrophin 2 [Source:NCBI gene;Acc:110015962])

HSP 1 Score: 187.578 bits (475), Expect = 1.240e-51
Identity = 118/358 (32.96%), Postives = 191/358 (53.35%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSV 1247
            M+ T +  ++N R       +LA WKGS+YK+++ + L++  +Y  I++ YR  L + QK+ F K+  + +     IP  F+LGF+V+ ++ RW   Y  IP   R   +  G + GN+    L LRR+++RY +L+ +L +R +S  +  RF          +++  +   F+                T  E + FE +   S  N       +YW+P  W + +   +     + D   +  ++EEL+  R     L  +  + +PLVYTQVV +AVYSFFL  L   QF+DP +  +GH+LD YVPIFT+ QF F  GWLKVA  ++NPFG+DD+DF+T+ ++D N   +  +V
Sbjct:    1 MTVTYTARVANARFCGFSKLLLA-WKGSIYKVLYKEFLAFFVLYAAISITYRFFLYEDQKRYFEKLAIYCNHYASLIPMSFVLGFYVTLIVNRWWNQYTSIPLPDRIMCVLSGGLQGNDERGRL-LRRSMMRYASLSALLILRSVSTAVFKRF---------PTMDHVVEAGFM----------------TREERKKFEGL--HSPYN-------KYWIPCVWFTNLAAVARCEGRIRDDHALKLLLEELNAFRGKCSLLFHYDMVSVPLVYTQVVTLAVYSFFLVCLIGRQFLDPSQGYQGHDLDLYVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNWLIDRNFQVSMMAV 322
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000055094.1 (SMESG000055094.1)

HSP 1 Score: 882.478 bits (2279), Expect = 0.000e+0
Identity = 472/472 (100.00%), Postives = 472/472 (100.00%), Query Frame = 3 
Query:  225 MVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFXXXXXXXXXXXXCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEXXXXXXXXXXXXXXXAPQSQTSFTSLHFDKRSETISQNKNNP 1640
            MVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPFFFLLGFFVSGVIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFLDEIDYDLEDLDCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEDNKLSKSKSNDSDPSAPQSQTSFTSLHFDKRSETISQNKNNP
Sbjct:    1 MVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPFFFLLGFFVSGVIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFLDEIDYDLEDLDCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEDNKLSKSKSNDSDPSAPQSQTSFTSLHFDKRSETISQNKNNP 472
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000055094.1 (SMESG000055094.1)

HSP 1 Score: 877.856 bits (2267), Expect = 0.000e+0
Identity = 472/489 (96.52%), Postives = 476/489 (97.34%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFXXXXXXXXXXXXCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEXXXXXXXXXXXXXXXAPQSQTSFTSLHFDKRSETISQNKNNP 1640
            M+   S  +  GR + I V +L  WKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPFFFLLGFFVSGVIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFLDEIDYDLEDLDCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEDNKLSKSKSNDSDPSAPQSQTSFTSLHFDKRSETISQNKNNP
Sbjct:    1 MTVDYSKQLEKGRGIDIFVRLLWLWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPFFFLLGFFVSGVIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFLDEIDYDLEDLDCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEDNKLSKSKSNDSDPSAPQSQTSFTSLHFDKRSETISQNKNNP 489
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000070057.1 (SMESG000070057.1)

HSP 1 Score: 488.804 bits (1257), Expect = 8.537e-169
Identity = 248/429 (57.81%), Postives = 325/429 (75.76%), Query Frame = 3 
Query:  174 MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNK-TQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFXXXXXXXXXXXXCTSETNEVKTLEMKDSIPKKIINYFK 1457
            M+ + S  IS+G+   I + +L +WKGSLYKLV+ DL+ Y+G+YY+INLIYR AL    QK++F ++V+F D MK NIP  FLLGFFV+GVI RW ++YL IP+L+R AFL +G ING +    L++R+T++RYLNL+WIL MRQ+SDQI +RF++N  NN+    E   R  FINFN+D KIQ+T+ KIITDAE+RAFE IA K+ S  K  + PE+WVPIQW+SR++QK+F+H ++SDPRT+N +I +LD +R  M  LQ+F GIMIPLVYTQV+IIAVYS+FLC+LFASQF+DP  K+ GHE+D YVPIFTIFQFLF MGWLKVAMCVMNPFGDDDEDFQTS+ILD+NLD T+RSV+ +  M+PE LDPP M Y+     + D L+ F+ +ID DLE+    +   +V  LE+    P K +N+ K
Sbjct:    1 MTVSYSEDISDGQGFMIFIKLLTRWKGSLYKLVYKDLMGYVGIYYVINLIYRFALKTPAQKRSFEEIVKFCDNMKNNIPISFLLGFFVTGVIARWFQLYLYIPYLNRMAFLSEGLINGGDKEKCLKIRQTLMRYLNLSWILCMRQVSDQIDIRFKHNDENNNE---EHHFRHTFINFNRDKKIQSTFRKIITDAEVRAFENIAAKNYSKTKSKFPPEFWVPIQWSSRLLQKAFVHGFISDPRTLNSIISDLDVLRGQMHTLQIFSGIMIPLVYTQVIIIAVYSYFLCQLFASQFVDPESKITGHEVDLYVPIFTIFQFLFFMGWLKVAMCVMNPFGDDDEDFQTSKILDDNLDVTFRSVTADSSMYPEHLDPPAMWYKTQKNCDEDLLDDFMKDIDSDLEETVQLNNEKDVTNLEIT---PNKCLNFLK 423
[Close]
BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000070057.1 (SMESG000070057.1)

HSP 1 Score: 478.404 bits (1230), Expect = 8.716e-165
Identity = 243/409 (59.41%), Postives = 314/409 (76.77%), Query Frame = 3 
Query:  234 ILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNK-TQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFXXXXXXXXXXXXCTSETNEVKTLEMKDSIPKKIINYFK 1457
            +L KWKGSLYKLV+ DL+ Y+G+YY+INLIYR AL    QK++F ++V+F D MK NIP  FLLGFFV+GVI RW ++YL IP+L+R AFL +G ING +    L++R+T++RYLNL+WIL MRQ+SDQI +RF++N  NN+    E   R  FINFN+D KIQ+T+ KIITDAE+RAFE IA K+ S  K  + PE+WVPIQW+SR++QK+F+H ++SDPRT+N +I +LD +R  M  LQ+F GIMIPLVYTQV+IIAVYS+FLC+LFASQF+DP  K+ GHE+D YVPIFTIFQFLF MGWLKVAMCVMNPFGDDDEDFQTS+ILD+NLD T+RSV+ +  M+PE LDPP M Y+     + D L+ F+ +ID DLE+    +   +V  LE+    P K +N+ K
Sbjct:   21 LLKKWKGSLYKLVYKDLMGYVGIYYVINLIYRFALKTPAQKRSFEEIVKFCDNMKNNIPISFLLGFFVTGVIARWFQLYLYIPYLNRMAFLSEGLINGGDKEKCLKIRQTLMRYLNLSWILCMRQVSDQIDIRFKHNDENNNE---EHHFRHTFINFNRDKKIQSTFRKIITDAEVRAFENIAAKNYSKTKSKFPPEFWVPIQWSSRLLQKAFVHGFISDPRTLNSIISDLDVLRGQMHTLQIFSGIMIPLVYTQVIIIAVYSYFLCQLFASQFVDPESKITGHEVDLYVPIFTIFQFLFFMGWLKVAMCVMNPFGDDDEDFQTSKILDDNLDVTFRSVTADSSMYPEHLDPPAMWYKTQKNCDEDLLDDFMKDIDSDLEETVQLNNEKDVTNLEIT---PNKCLNFLK 423
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BLAST of Bestrophin homolog vs. Planmine SMEST
Match: SMESG000065100.1 (SMESG000065100.1)

HSP 1 Score: 453.751 bits (1166), Expect = 1.646e-155
Identity = 222/382 (58.12%), Postives = 286/382 (74.87%), Query Frame = 3 
Query:  198 ISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLIYRLALNKTQKKTFVKMVQFADEMKGNIPXXXXXXXXXXXXIGRWIKMYLLIPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQISLRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEAIAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEELDRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKVKGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNNLDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETF 1343
            IS+G+ LY + T+  +WKGSLYKL+WVDLL Y+G+YYLIN++YR ALN+ Q++ F ++V+F D  K NIP  FLLGFFV+G+IGRW KMYL IPWL++ AF+ Q  I GN P  S R+R  I+RY+NLAWIL MR IS QI +RF+ +K        E  I++I  N N D +I+ T+ KIIT +EIRAFE IA+K ++  K  Y PE+WVPIQWASR+I K FIH ++SDPRT+  + EE++ +R  MQNLQ++  I+IPLVYTQVV+IAVYS+FL  LFA+QF+DP +++ GHE+DFY+P+FTIFQFLF+MGWLKVAMCVMNPFGDDDEDFQTSE+LD NLD ++RS     EM+P  L P  M Y      + DNL  F
Sbjct:    9 ISDGQGLYCIYTLFMRWKGSLYKLLWVDLLIYVGLYYLINIMYRFALNEQQRRIFEEIVKFCDSKKNNIPLSFLLGFFVAGIIGRWWKMYLCIPWLNKIAFICQSIIIGNGPVKSRRVRLIIMRYMNLAWILLMRNISAQIKVRFQQHKNMKVNYRSENYIKEILENINADERIRQTFKKIITVSEIRAFENIALKYNTRNKIRYEPEFWVPIQWASRIIHKCFIHGFISDPRTMTSLNEEVEELREQMQNLQIYSNILIPLVYTQVVVIAVYSYFLVHLFAAQFVDPGQRIVGHEVDFYIPVFTIFQFLFMMGWLKVAMCVMNPFGDDDEDFQTSEMLDYNLDISFRSSEASEEMYPSLLKPAIMKYRLQDAVDEDNLPDF 390
The following BLAST results are available for this feature:
BLAST of Bestrophin homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BEST17.241e-5834.68bestrophin 1 [Source:HGNC Symbol;Acc:HGNC:12703][more]
BEST32.017e-5633.79bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST31.439e-5433.79bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
BEST25.575e-5333.24bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
BEST25.575e-5333.24bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107][more]
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BLAST of Bestrophin homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best-41.026e-4831.49Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-232.637e-4833.53Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:A... [more]
best-83.278e-4631.32Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-83.278e-4631.32Bestrophin homolog [Source:UniProtKB/TrEMBL;Acc:O... [more]
best-51.535e-4228.97Bestrophin homolog 5 [Source:UniProtKB/Swiss-Prot... [more]
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BLAST of Bestrophin homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best13.209e-5734.76gene:FBgn0040238 transcript:FBtr0082183[more]
Best14.251e-5734.76gene:FBgn0040238 transcript:FBtr0337020[more]
Best17.014e-5734.76gene:FBgn0040238 transcript:FBtr0114590[more]
Best18.688e-5734.76gene:FBgn0040238 transcript:FBtr0306023[more]
Best43.625e-5633.24gene:FBgn0036491 transcript:FBtr0113172[more]
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BLAST of Bestrophin homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best14.014e-5532.70bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
best28.691e-5333.78bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best41.069e-4932.37bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best42.382e-4933.23bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best13.097e-3441.06bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
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BLAST of Bestrophin homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best16.922e-5732.87bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best11.290e-5632.87bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best13.365e-5632.87bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best13.663e-5632.87bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
best14.605e-5532.87bestrophin 1 [Source:NCBI gene;Acc:100302038][more]
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BLAST of Bestrophin homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Best14.899e-5633.51bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best11.988e-5533.61bestrophin 1 [Source:MGI Symbol;Acc:MGI:1346332][more]
Best22.143e-5333.80bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best22.143e-5333.80bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
Best22.143e-5333.80bestrophin 2 [Source:MGI Symbol;Acc:MGI:2387588][more]
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BLAST of Bestrophin homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O76090|BEST1_HUMAN3.477e-5734.68Bestrophin-1 OS=Homo sapiens OX=9606 GN=BEST1 PE=1... [more]
sp|Q6UY87|BEST1_MACFA9.440e-5734.41Bestrophin-1 OS=Macaca fascicularis OX=9541 GN=BES... [more]
sp|O88870|BEST1_MOUSE1.391e-5433.61Bestrophin-1 OS=Mus musculus OX=10090 GN=Best1 PE=... [more]
sp|Q8N1M1|BEST3_HUMAN6.911e-5433.79Bestrophin-3 OS=Homo sapiens OX=9606 GN=BEST3 PE=1... [more]
sp|Q8BGM5|BEST2_MOUSE2.077e-5233.80Bestrophin-2 OS=Mus musculus OX=10090 GN=Best2 PE=... [more]
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BLAST of Bestrophin homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0S0466.771e-9941.00Bestrophin homolog OS=Fasciola hepatica OX=6192 GN... [more]
A0A267F2G91.086e-9744.25Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A267FNT54.174e-9743.50Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
A0A1I8HMQ96.431e-9743.50Bestrophin homolog OS=Macrostomum lignano OX=28230... [more]
W6UHI33.975e-9638.13Bestrophin homolog OS=Echinococcus granulosus OX=6... [more]
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BLAST of Bestrophin homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
best13.888e-5432.97bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
best21.718e-5033.24bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best41.219e-4631.52bestrophin 4 [Source:ZFIN;Acc:ZDB-GENE-070912-6][more]
best11.887e-4330.79bestrophin-2 [Source:NCBI gene;Acc:103045999][more]
BEST36.072e-3235.32bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105][more]
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BLAST of Bestrophin homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best26.737e-5432.15bestrophin 2 [Source:ZFIN;Acc:ZDB-GENE-090312-127][more]
best12.936e-5232.71bestrophin 1 [Source:ZFIN;Acc:ZDB-GENE-110411-214][more]
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BLAST of Bestrophin homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bestrophin homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
BEST34.342e-5634.25bestrophin 3 [Source:NCBI gene;Acc:101172121][more]
best11.121e-5231.79bestrophin-2 [Source:NCBI gene;Acc:101167866][more]
best21.240e-5132.96bestrophin 2 [Source:NCBI gene;Acc:110015962][more]
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BLAST of Bestrophin homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000055094.10.000e+0100.00SMESG000055094.1[more]
SMESG000055094.10.000e+096.52SMESG000055094.1[more]
SMESG000070057.18.537e-16957.81SMESG000070057.1[more]
SMESG000070057.18.716e-16559.41SMESG000070057.1[more]
SMESG000065100.11.646e-15558.12SMESG000065100.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020985 ID=SMED30020985|Name=Bestrophin homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1746bp
CAAAATATAATCAGCAACCCGTACAGTGAAAACCTGGAACAATACAAAGT
ACAATGAATCGATTGTTAATATTATTTCTCTCTCTCTCTGTCACAATTGA
CATTAAATTGTAATTCGAAAACAAAAATTACGCGTAATTATCGATTGTTT
ACTATTACTAATACTACTCATTAATGAGCGGCACAAATTCAAATATCATC
TCAAATGGAAGGTCATTGTACATAATGGTTACAATCTTGGCCAAATGGAA
AGGCAGTTTGTACAAATTGGTCTGGGTGGATCTGCTGTCATATATGGGCG
TTTATTACCTCATAAATCTCATCTACCGGCTGGCATTGAATAAAACCCAG
AAAAAGACATTTGTGAAAATGGTTCAATTTGCTGATGAAATGAAAGGAAA
TATTCCGTTTTTCTTTTTGCTGGGATTCTTTGTATCGGGAGTTATAGGAA
GATGGATAAAAATGTATTTATTAATTCCCTGGCTTCACAGACAGGCATTT
CTATTCCAGGGCTGTATTAATGGCAATGAACCGGCGATGTCCCTACGGTT
ACGAAGAACCATTTTGCGGTATTTGAATTTGGCTTGGATATTACAAATGC
GTCAAATCAGCGATCAGATATCTCTCAGATTTCGAAATAATAAGATTAAT
AATTCTACAAATAGTGTTGAAACAACCATTCGAGATATATTTATCAATTT
CAATAAGGATCCAAAAATTCAAAACACGTACGGCAAAATTATAACCGACG
CCGAAATTCGAGCTTTTGAAGCAATTGCTATTAAAAGCGATTCAAATGGC
AAACCAAATTATGTTCCCGAATATTGGGTTCCCATTCAGTGGGCCTCAAG
AGTAATCCAGAAATCCTTTATTCATAAATATGTCAGTGATCCGAGAACGG
TCAACAAAATGATAGAGGAACTTGATCGCGTGAGAAATAACATGCAAAAT
TTGCAAGTATTTTGTGGAATAATGATACCGTTGGTTTATACTCAGGTAGT
TATTATTGCTGTTTACAGTTTCTTTCTATGTGAACTTTTTGCTTCGCAAT
TTATCGACCCAAGAGAAAAGGTTAAAGGTCACGAATTGGATTTTTATGTC
CCAATATTCACAATATTTCAATTCCTATTCCTTATGGGATGGTTAAAAGT
TGCAATGTGCGTCATGAATCCATTCGGTGATGATGACGAAGATTTCCAAA
CTTCAGAGATTTTAGATAATAATTTAGATACGACATATCGATCGGTGTCA
GGAGAATTAGAAATGTTTCCAGAAAGATTGGATCCTCCAAAAATGAATTA
CGAGTGTCTTTTAAAAACTGAGCCAGATAACCTTGAAACTTTTCTCGATG
AAATAGATTATGACCTTGAAGATCTAGATTGCACCAGTGAAACAAACGAA
GTAAAAACATTGGAAATGAAAGATTCAATACCAAAAAAAATAATCAACTA
CTTCAAATCAAAAGGTACAACACGAAGGACTGATGGTCTAAGGCAATTAA
TTTCAATCGAAGAAGATAACAAATTATCTAAAAGTAAATCCAATGATTCC
GACCCCTCGGCACCGCAATCTCAGACCAGTTTCACAAGTCTCCACTTCGA
TAAAAGATCAGAAACCATTTCCCAGAATAAAAATAATCCATAAATTTGAG
AAACATAAAGTGATAAATAAATTATTTAAAACCAATTTATTTATATTTAG
CAGTTTATAATATAATCTTTCATTTATTAATTGTAATAATCTACAA
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protein sequence of SMED30020985-orf-1

>SMED30020985-orf-1 ID=SMED30020985-orf-1|Name=SMED30020985-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=490bp
MSGTNSNIISNGRSLYIMVTILAKWKGSLYKLVWVDLLSYMGVYYLINLI
YRLALNKTQKKTFVKMVQFADEMKGNIPFFFLLGFFVSGVIGRWIKMYLL
IPWLHRQAFLFQGCINGNEPAMSLRLRRTILRYLNLAWILQMRQISDQIS
LRFRNNKINNSTNSVETTIRDIFINFNKDPKIQNTYGKIITDAEIRAFEA
IAIKSDSNGKPNYVPEYWVPIQWASRVIQKSFIHKYVSDPRTVNKMIEEL
DRVRNNMQNLQVFCGIMIPLVYTQVVIIAVYSFFLCELFASQFIDPREKV
KGHELDFYVPIFTIFQFLFLMGWLKVAMCVMNPFGDDDEDFQTSEILDNN
LDTTYRSVSGELEMFPERLDPPKMNYECLLKTEPDNLETFLDEIDYDLED
LDCTSETNEVKTLEMKDSIPKKIINYFKSKGTTRRTDGLRQLISIEEDNK
LSKSKSNDSDPSAPQSQTSFTSLHFDKRSETISQNKNNP*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR000615Bestrophin
IPR021134Bestrophin/UPF0187
Vocabulary: molecular function
TermDefinition
GO:0005254chloride channel activity
Vocabulary: cellular component
TermDefinition
GO:0005886plasma membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:1902476chloride transmembrane transport
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 243..263
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 456..489
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 446..489
NoneNo IPR availableTMHMMTMhelixcoord: 262..284
NoneNo IPR availableTMHMMTMhelixcoord: 76..95
NoneNo IPR availableTMHMMTMhelixcoord: 33..55
NoneNo IPR availableTMHMMTMhelixcoord: 305..324
IPR021134Bestrophin/UPF0187PFAMPF01062Bestrophincoord: 18..351
e-value: 2.7E-66
score: 223.9
IPR000615BestrophinPANTHERPTHR10736BESTROPHINcoord: 14..467