MAP kinase-activating death domain protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020839 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Match: MADD (MAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]) HSP 1 Score: 497.278 bits (1279), Expect = 3.482e-148 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 204.527 bits (519), Expect = 3.797e-52 Identity = 104/270 (38.52%), Postives = 162/270 (60.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1198 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINL 1466 HSP 3 Score: 58.9214 bits (141), Expect = 1.240e-7 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 869 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1008
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Match: MADD (MAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]) HSP 1 Score: 498.434 bits (1282), Expect = 4.527e-148 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 216.468 bits (550), Expect = 7.995e-56 Identity = 114/320 (35.62%), Postives = 186/320 (58.13%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1194 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1511 HSP 3 Score: 58.5362 bits (140), Expect = 1.326e-7 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 869 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1008
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Match: MADD (MAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]) HSP 1 Score: 498.434 bits (1282), Expect = 4.837e-148 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 216.468 bits (550), Expect = 7.763e-56 Identity = 114/320 (35.62%), Postives = 186/320 (58.13%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1198 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1515 HSP 3 Score: 58.5362 bits (140), Expect = 1.407e-7 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 869 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1008
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Match: MADD (MAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]) HSP 1 Score: 498.434 bits (1282), Expect = 6.264e-148 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 216.853 bits (551), Expect = 7.479e-56 Identity = 114/320 (35.62%), Postives = 186/320 (58.13%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1218 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1535 HSP 3 Score: 58.5362 bits (140), Expect = 1.484e-7 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 889 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1028
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Match: MADD (MAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]) HSP 1 Score: 497.278 bits (1279), Expect = 1.958e-147 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 196.823 bits (499), Expect = 9.148e-50 Identity = 103/290 (35.52%), Postives = 163/290 (56.21%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1279 SQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINL 1568 HSP 3 Score: 58.5362 bits (140), Expect = 1.343e-7 Identity = 34/133 (25.56%), Postives = 67/133 (50.38%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 940 ENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1071
BLAST of MAP kinase-activating death domain protein vs. Ensembl Celegans
Match: aex-3 (MAP kinase-activating death domain protein [Source:UniProtKB/Swiss-Prot;Acc:O02626]) HSP 1 Score: 437.573 bits (1124), Expect = 4.398e-128 Identity = 243/593 (40.98%), Postives = 340/593 (57.34%), Query Frame = 2 Query: 182 ICPRLIDYLSIVGLRNPNRSGHKNS---------VVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTS--RNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIK--VTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTH-SLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLP--PPADFNILIKHIKQALKVCQALNSIS----DKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 ICPRLID+L +VG RN R ++S PE+LRRYP DHK+ LP DV FCQP+GC +T +NA D FVF LT+K++ +VRYGICLNF++ +RRS K + +V + + KR +H SLTSL +SHHP F L +LK II+ + R +R+ KD +W L G E + ++ EIETWI LLSSPVPV G T++++ ++P L + FALPD+ RF L+DFPLH FE++G++ AL++ A +LE K+++QS+NYN +S IL++ ALLYPLEYMFP+ LLP +MPSAEQL AP+PF+ G+PSSF RK ++PSDV DLD L + +DL +P P D H+K+ LK A+N ++ D V + D FG D DSVDV+ RVAMV+FFNS ++ GN+++ TR L+LYPRP+V+ Q D+F++SR + + L +TQAV++F E + PKN F ++ + +GDK KWF +SL P++F VY N + Sbjct: 8 ICPRLIDFLVVVGKRNRTRGASQSSPDATTDTTVTYPEILRRYPTDDHKDFILPTDVTVFCQPEGCTTTSARLRKNARNDPQFFVFMLTEKDSAKVRYGICLNFYQSFDRRSTPKDEIKKVPDD--------------------AHHKKR---DSHVSLTSLCFISHHPFVSIFHQVLLLLKRIIDSSNHRAAQRTGLKDVVWAILTGHYNEPIVPEVMKEIKEIETWILMLLSSPVPVPGKTKVQIEVMPMDLSQVFEFALPDHTRFTLIDFPLHIPFEILGIDMALRVLTAAMLEFKIVIQSRNYNAVSMCILSIVALLYPLEYMFPVIPLLPAYMPSAEQLLLAPTPFLIGVPSSFFHHRKIRELPSDVILVDLDTNCL------------QVPDDLYIPDLPEPDAT----HLKERLK--NAINKMTTMTVDNETSVTDAD-------------------------FGIDIDSVDVACRVAMVQFFNSANVFGNFSEHTRTLRLYPRPVVSLQTDSFLRSRPQCTQLITDLCRTQAVEYFAECCLCPKNETFVRVQAGIESAEQVGDKPKWFSESLMPVHFMVYPNNST 534 HSP 2 Score: 194.512 bits (493), Expect = 1.487e-49 Identity = 108/315 (34.29%), Postives = 174/315 (55.24%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQ----AIQKHSEKFRSVIEPDT--SQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSA 4657 R Y++Q+L + +IW N+ FWE+ F D V QEREI+G+DQ+ +++DRY+ L+ +EK+RLE EDRLL +L+N A+MIM ++ K R ++GK+HI L S INKL+D + +GN + L SR Q F V G G + E+ D ++LRSI+GA RWW ER + T K ++C+ RR +++V M + + KK +EL Q A+++ + + + +E +F V D T G L++ +G+ + F+ N+++C T + F++E D + R + S A Sbjct: 1071 RHYIYQELILAV-QHQIWQNLQFWENAFVDLVAQEREIVGMDQEPSEMIDRYSALNDSEKKRLELEEDRLLSTLLHNMTAYMIMCGTGQKALQQKVRRLLGKAHIGLVCSKEINKLLDELPSTQGNFIPLKPLGSRLVQKQSFTVCPGQSSDGQMMFMEVCDDAVVLRSITGAATERWWYERLVNITYSPKTKILCLWRRHDDKVHMHKFHTKKCRELYQCMKAAMERAAARGKVNVEGRALGGEFPVHDTETNQGGLLQVRCDGVAVIFAHNQIFIGLSNIKKCNTFGGNVFLLEEFDRKKGEIIQRRYFSQMA 1384 HSP 3 Score: 76.6406 bits (187), Expect = 1.641e-13 Identity = 50/171 (29.24%), Postives = 92/171 (53.80%), Query Frame = 2 Query: 2507 QEILKSNPTYKPISER--KPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKG 3013 Q I K+ P + + ER KP L N+++++ R + + + + +NQ+T+++ D+ L G + + S ++K ++E+E+ R L+ S++N LE ++ ++ Y+ +V + ++ F A V I + + GIE S+N C GF SVF LE+ THY G Sbjct: 733 QVINKTAPKAQALKERTMKP------LANRIEQSQHIVRSKTQPNPTSQQTANQQSKNQQTVKEFCDQALVGQSVGMFSAPKLKRLMEDESLRELVCSKLNLGLEVKLS-EDEYVKEVQL-TKGQFKAYVKILKACLEGIEVSFNTPGCCGFASVFHVLEIAHTHYWAMGG 895
BLAST of MAP kinase-activating death domain protein vs. Ensembl Celegans
Match: aex-3 (MAP kinase-activating death domain protein [Source:UniProtKB/Swiss-Prot;Acc:O02626]) HSP 1 Score: 437.573 bits (1124), Expect = 4.598e-128 Identity = 243/593 (40.98%), Postives = 340/593 (57.34%), Query Frame = 2 Query: 182 ICPRLIDYLSIVGLRNPNRSGHKNS---------VVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTS--RNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIK--VTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTH-SLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLP--PPADFNILIKHIKQALKVCQALNSIS----DKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 ICPRLID+L +VG RN R ++S PE+LRRYP DHK+ LP DV FCQP+GC +T +NA D FVF LT+K++ +VRYGICLNF++ +RRS K + +V + + KR +H SLTSL +SHHP F L +LK II+ + R +R+ KD +W L G E + ++ EIETWI LLSSPVPV G T++++ ++P L + FALPD+ RF L+DFPLH FE++G++ AL++ A +LE K+++QS+NYN +S IL++ ALLYPLEYMFP+ LLP +MPSAEQL AP+PF+ G+PSSF RK ++PSDV DLD L + +DL +P P D H+K+ LK A+N ++ D V + D FG D DSVDV+ RVAMV+FFNS ++ GN+++ TR L+LYPRP+V+ Q D+F++SR + + L +TQAV++F E + PKN F ++ + +GDK KWF +SL P++F VY N + Sbjct: 8 ICPRLIDFLVVVGKRNRTRGASQSSPDATTDTTVTYPEILRRYPTDDHKDFILPTDVTVFCQPEGCTTTSARLRKNARNDPQFFVFMLTEKDSAKVRYGICLNFYQSFDRRSTPKDEIKKVPDD--------------------AHHKKR---DSHVSLTSLCFISHHPFVSIFHQVLLLLKRIIDSSNHRAAQRTGLKDVVWAILTGHYNEPIVPEVMKEIKEIETWILMLLSSPVPVPGKTKVQIEVMPMDLSQVFEFALPDHTRFTLIDFPLHIPFEILGIDMALRVLTAAMLEFKIVIQSRNYNAVSMCILSIVALLYPLEYMFPVIPLLPAYMPSAEQLLLAPTPFLIGVPSSFFHHRKIRELPSDVILVDLDTNCL------------QVPDDLYIPDLPEPDAT----HLKERLK--NAINKMTTMTVDNETSVTDAD-------------------------FGIDIDSVDVACRVAMVQFFNSANVFGNFSEHTRTLRLYPRPVVSLQTDSFLRSRPQCTQLITDLCRTQAVEYFAECCLCPKNETFVRVQAGIESAEQVGDKPKWFSESLMPVHFMVYPNNST 534 HSP 2 Score: 196.052 bits (497), Expect = 6.087e-50 Identity = 109/318 (34.28%), Postives = 176/318 (55.35%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQ----AIQKHSEKFRSVIEPDT--SQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R Y++Q+L + +IW N+ FWE+ F D V QEREI+G+DQ+ +++DRY+ L+ +EK+RLE EDRLL +L+N A+MIM ++ K R ++GK+HI L S INKL+D + +GN + L SR Q F V G G + E+ D ++LRSI+GA RWW ER + T K ++C+ RR +++V M + + KK +EL Q A+++ + + + +E +F V D T G L++ +G+ + F+ N+++C T + F++E D + R + S A+ I Sbjct: 1071 RHYIYQELILAV-QHQIWQNLQFWENAFVDLVAQEREIVGMDQEPSEMIDRYSALNDSEKKRLELEEDRLLSTLLHNMTAYMIMCGTGQKALQQKVRRLLGKAHIGLVCSKEINKLLDELPSTQGNFIPLKPLGSRLVQKQSFTVCPGQSSDGQMMFMEVCDDAVVLRSITGAATERWWYERLVNITYSPKTKILCLWRRHDDKVHMHKFHTKKCRELYQCMKAAMERAAARGKVNVEGRALGGEFPVHDTETNQGGLLQVRCDGVAVIFAHNQIFIGLSNIKKCNTFGGNVFLLEEFDRKKGEIIQRRYFSQMADQI 1387 HSP 3 Score: 76.6406 bits (187), Expect = 1.712e-13 Identity = 50/171 (29.24%), Postives = 92/171 (53.80%), Query Frame = 2 Query: 2507 QEILKSNPTYKPISER--KPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKG 3013 Q I K+ P + + ER KP L N+++++ R + + + + +NQ+T+++ D+ L G + + S ++K ++E+E+ R L+ S++N LE ++ ++ Y+ +V + ++ F A V I + + GIE S+N C GF SVF LE+ THY G Sbjct: 733 QVINKTAPKAQALKERTMKP------LANRIEQSQHIVRSKTQPNPTSQQTANQQSKNQQTVKEFCDQALVGQSVGMFSAPKLKRLMEDESLRELVCSKLNLGLEVKLS-EDEYVKEVQL-TKGQFKAYVKILKACLEGIEVSFNTPGCCGFASVFHVLEIAHTHYWAMGG 895
BLAST of MAP kinase-activating death domain protein vs. Ensembl Celegans
Match: lst-6 (Lateral Signaling Target [Source:UniProtKB/TrEMBL;Acc:Q18780]) HSP 1 Score: 53.9138 bits (128), Expect = 1.342e-6 Identity = 46/155 (29.68%), Postives = 78/155 (50.32%), Query Frame = 2 Query: 812 IETWIFRLLSS-PVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLD 1273 +E++I+ L P+P +T +++ LL TL V P P D + +IF+ + VE ++LF LLE++++L SK+ + L T +L AL +P + + +LP S F AP P++ G + + F+ S+V DLD Sbjct: 235 LESYIYWCLYEVPLPSPSMT-LKIPLLGTTL----VVQRPGPKELPFFDDSIGSIFDYLPVEKFIRLFSCFLLEHQILLCSKDLSRLMTVCESLLALSFPFRWQMTYAPVLPY---SKLDFFEAPVPYVMGWYYEDTVPEELFQ--SNVCVVDLD 379
BLAST of MAP kinase-activating death domain protein vs. Ensembl Celegans
Match: mtm-5 (Myotubularin-related protein 5 [Source:UniProtKB/Swiss-Prot;Acc:Q9TXP3]) HSP 1 Score: 51.6026 bits (122), Expect = 7.535e-6 Identity = 27/92 (29.35%), Postives = 53/92 (57.61%), Query Frame = 2 Query: 944 PLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFL 1219 P+ + +F+++G + +K+ A+L + +++L S + LS A+ +LLYP EY+ T+LP S ++ +P+PF+ G+ S F+ Sbjct: 175 PVTGKDVAMLFKMLGFQNVIKIIHALLSDCRIVLASSSLMRLSRCQNAILSLLYPFEYVHSCVTILP---DSLAEVLESPTPFLIGVLSEFV 263
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Match: Rab3-GEF (gene:FBgn0030613 transcript:FBtr0330400) HSP 1 Score: 404.06 bits (1037), Expect = 8.605e-115 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 238 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 804 HSP 2 Score: 229.18 bits (583), Expect = 7.671e-60 Identity = 121/319 (37.93%), Postives = 184/319 (57.68%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLIFRLFQ 4681 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ G+ N+ +FV ++R+CFT+K F++E +P T+NL R ++S A+ I F Sbjct: 1452 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMASEIVLSFH 1769 HSP 3 Score: 123.25 bits (308), Expect = 1.518e-27 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.1738 bits (178), Expect = 2.452e-12 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1139 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1297
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Match: Rab3-GEF (gene:FBgn0030613 transcript:FBtr0307210) HSP 1 Score: 404.06 bits (1037), Expect = 8.915e-115 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 238 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 804 HSP 2 Score: 225.328 bits (573), Expect = 9.510e-59 Identity = 123/322 (38.20%), Postives = 188/322 (58.39%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKI--DKNGLTFT-SDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLIFRLFQ 4681 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ + GL F+ S + ++FV ++R+CFT+K F++E +P T+NL R ++S A+ I F Sbjct: 1452 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKDFEFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMASEIVLSFH 1772 HSP 3 Score: 123.25 bits (308), Expect = 1.545e-27 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.1738 bits (178), Expect = 2.313e-12 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1139 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1297
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Match: Rab3-GEF (gene:FBgn0030613 transcript:FBtr0307209) HSP 1 Score: 405.216 bits (1040), Expect = 1.256e-114 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 246 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 812 HSP 2 Score: 228.409 bits (581), Expect = 1.286e-59 Identity = 119/314 (37.90%), Postives = 183/314 (58.28%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ G+ N+ +FV ++R+CFT+K F++E +P T+NL R ++S ++ I Sbjct: 1492 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQI 1804 HSP 3 Score: 123.635 bits (309), Expect = 1.284e-27 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.559 bits (179), Expect = 2.133e-12 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1147 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1305
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Match: Rab3-GEF (gene:FBgn0030613 transcript:FBtr0307208) HSP 1 Score: 404.831 bits (1039), Expect = 1.547e-114 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 235 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 801 HSP 2 Score: 228.409 bits (581), Expect = 1.580e-59 Identity = 119/314 (37.90%), Postives = 183/314 (58.28%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ G+ N+ +FV ++R+CFT+K F++E +P T+NL R ++S ++ I Sbjct: 1498 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQI 1810 HSP 3 Score: 123.635 bits (309), Expect = 1.375e-27 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.1738 bits (178), Expect = 2.421e-12 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1153 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1311
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Match: Rab3-GEF (gene:FBgn0030613 transcript:FBtr0307207) HSP 1 Score: 404.445 bits (1038), Expect = 2.008e-114 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 238 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 804 HSP 2 Score: 228.409 bits (581), Expect = 1.547e-59 Identity = 119/314 (37.90%), Postives = 183/314 (58.28%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ G+ N+ +FV ++R+CFT+K F++E +P T+NL R ++S ++ I Sbjct: 1452 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQI 1764 HSP 3 Score: 123.635 bits (309), Expect = 1.376e-27 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.1738 bits (178), Expect = 2.624e-12 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1139 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1297
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Match: BX119977.1 (MAP-kinase activating death domain [Source:NCBI gene;Acc:100150917]) HSP 1 Score: 501.516 bits (1290), Expect = 9.406e-150 Identity = 265/590 (44.92%), Postives = 369/590 (62.54%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRP--RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRR-----SNGKDSIWPTLLGS-SVENT--NSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G RYGICLNF+R ++ R E + G+ S++S RI P R LTSL I+SH+P F F+ CL ILK +++ +R+ +R S +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG R+++ +LP L + FALPD RF +VDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF L + FKMP DVW DLD N +VP P A + L KH+KQ + AL S+S ++P+ NL++ + EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F +KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 2 MEKKKMCPRLLDYLVVVGARQP--SNDSVAQTPQLLRRYPLEDHNDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDTSFVFTLTDKDSGITRYGICLNFYRSFQKAH----HRPRAEGKGDGTLLPGEPGSSGKSPRSKRSGRIAPQNRNSMLTSLCILSHYPFFSTFRECLYILKRMVDCCSQRLNQRPGAPKSTQRDTMWRVFTGALSVEEKEKGSQVLQDLREIESWVYRLLRSPVPVAGQRRVDVEVLPHELQPALTFALPDPSRFSIVDFPLHLPLELLGVDACLQVLACILLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYVIGVPASFFLYKCDFKMPDDVWLVDLDC-------NKVIVPSNAELLPPLPEPEA--SELKKHLKQ-VNAADALASMSLNTQPILNLEKFQDGQELSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRNGFTEKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 575 HSP 2 Score: 210.305 bits (534), Expect = 4.471e-54 Identity = 110/296 (37.16%), Postives = 173/296 (58.45%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVE 4600 R+YL + L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+MM+V I+ K R ++GKSHI L S IN+++D + +L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E Sbjct: 1152 RIYLCEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELNHIKKCNTVK-GVFVLE 1445 HSP 3 Score: 62.7734 bits (151), Expect = 5.020e-9 Identity = 32/113 (28.32%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 904 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEI-NRKVYKGMLDILKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 1015
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Match: madd (MAP-kinase activating death domain [Source:ZFIN;Acc:ZDB-GENE-030131-8076]) HSP 1 Score: 497.278 bits (1279), Expect = 3.559e-148 Identity = 265/594 (44.61%), Postives = 370/594 (62.29%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER--RSPIKVTRVXXXXXXXXXXXXXXXFQG--GRESMSRQSKRIRP--RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRR-----SNGKDSIWPTLLGS-SVE--NTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G RYGICLNF+R ++ P + + + G G+ S++S RI P R LTSL I+SH+P F F+ CL ILK +++ +R+ +R S +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG R+++ +LP L + FALPD RF +VDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF L + FKMP DVW DLD N +VP P A + L KH+KQAL S+S ++P+ NL++ + EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F +KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SNDSVAQTPQLLRRYPLEDHNDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDTSFVFTLTDKDSGITRYGICLNFYRSFQKAHHRPRAEGKGEHSAPPAGDGTLLPGEPGSSGKSPRSKRSGRIAPQNRNSMLTSLCILSHYPFFSTFRECLYILKRMVDCCSQRLNQRPGAPKSTQRDTMWRVFTGALSVEEKEKGSQVLQDLREIESWVYRLLRSPVPVAGQRRVDVEVLPHELQPALTFALPDPSRFSIVDFPLHLPLELLGVDACLQVLACILLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYVIGVPASFFLYKCDFKMPDDVWLVDLDC-------NKVIVPSNAELLPPLPEPEA--SELKKHLKQALA------SMSLNTQPILNLEKFQDGQELSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRNGFTEKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 577 HSP 2 Score: 219.55 bits (558), Expect = 6.754e-57 Identity = 123/339 (36.28%), Postives = 190/339 (56.05%), Query Frame = 2 Query: 3674 PVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 PV N VE SM R+YL + L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+MM+V I+ K R ++GKSHI L S IN+++D + +L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E P TK + +K+ A+ I Sbjct: 1142 PVGVNKAAPAPPVEDVSM---RIYLCEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELNHIKKCNTVK-GVFVLEEFVPETKEVVIHKYKTPMAHQI 1475 HSP 3 Score: 62.7734 bits (151), Expect = 4.783e-9 Identity = 32/113 (28.32%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 903 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEI-NRKVYKGMLDILKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 1014
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Match: BX119977.1 (MAP-kinase activating death domain [Source:NCBI gene;Acc:100150917]) HSP 1 Score: 495.738 bits (1275), Expect = 5.928e-148 Identity = 265/594 (44.61%), Postives = 366/594 (61.62%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWR----PIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRP--RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRR-----SNGKDSIWPTLLGS-SVENT--NSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G RYGICLNF+R E+ P +T S++S RI P R LTSL I+SH+P F F+ CL ILK +++ +R+ +R S +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG R+++ +LP L + FALPD RF +VDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF L + FKMP DVW DLD N +VP P A + L KH+KQAL S+S ++P+ NL++ + EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F +KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 2 MEKKKMCPRLLDYLVVVGARQP--SNDSVAQTPQLLRRYPLEDHNDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDTSFVFTLTDKDSGITRYGICLNFYRSFQKATEKSDPSTLT-------------LSGEHSAPPSPRSKRSGRIAPQNRNSMLTSLCILSHYPFFSTFRECLYILKRMVDCCSQRLNQRPGAPKSTQRDTMWRVFTGALSVEEKEKGSQVLQDLREIESWVYRLLRSPVPVAGQRRVDVEVLPHELQPALTFALPDPSRFSIVDFPLHLPLELLGVDACLQVLACILLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYVIGVPASFFLYKCDFKMPDDVWLVDLDC-------NKVIVPSNAELLPPLPEPEA--SELKKHLKQALA------SMSLNTQPILNLEKFQDGQELSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRNGFTEKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 565 HSP 2 Score: 211.075 bits (536), Expect = 2.470e-54 Identity = 117/317 (36.91%), Postives = 180/317 (56.78%), Query Frame = 2 Query: 3674 PVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVE 4600 PV N VE SM R+YL + L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+MM+V I+ K R ++GKSHI L S IN+++D + +L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E Sbjct: 1101 PVGVNKAAPAPPVEDVSM---RIYLCEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELNHIKKCNTVK-GVFVLE 1412 HSP 3 Score: 62.7734 bits (151), Expect = 4.633e-9 Identity = 32/113 (28.32%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 798 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEI-NRKVYKGMLDILKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 909
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Match: BX119977.1 (MAP-kinase activating death domain [Source:NCBI gene;Acc:100150917]) HSP 1 Score: 496.508 bits (1277), Expect = 2.564e-147 Identity = 265/608 (43.59%), Postives = 377/608 (62.01%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWR----------PIERRSPIKVTRVXXXXXXXXXXXXXXXFQG--------GRESMSRQSKRIRP--RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRR-----SNGKDSIWPTLLGS-SVENT--NSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G RYGICLNF+R P + ++ T S + S + G G+ S++S RI P R LTSL I+SH+P F F+ CL ILK +++ +R+ +R S +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG R+++ +LP L + FALPD RF +VDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF L + FKMP DVW DLD +++ +N +++P + + L KH+KQAL S+S ++P+ NL++ + EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F +KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 2 MEKKKMCPRLLDYLVVVGARQP--SNDSVAQTPQLLRRYPLEDHNDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDTSFVFTLTDKDSGITRYGICLNFYRSFQKAHHREKPAHTDTAVEATEKSDPSTLTLSGEHSAPPAGDGTLLPGDGKSPRSKRSGRIAPQNRNSMLTSLCILSHYPFFSTFRECLYILKRMVDCCSQRLNQRPGAPKSTQRDTMWRVFTGALSVEEKEKGSQVLQDLREIESWVYRLLRSPVPVAGQRRVDVEVLPHELQPALTFALPDPSRFSIVDFPLHLPLELLGVDACLQVLACILLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYVIGVPASFFLYKCDFKMPDDVWLVDLDCNKVIVPSNAELLPPLPE---------PEASELKKHLKQALA------SMSLNTQPILNLEKFQDGQELSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRNGFTEKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 592 HSP 2 Score: 211.846 bits (538), Expect = 1.399e-54 Identity = 117/317 (36.91%), Postives = 180/317 (56.78%), Query Frame = 2 Query: 3674 PVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVE 4600 PV N VE SM R+YL + L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+MM+V I+ K R ++GKSHI L S IN+++D + +L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E Sbjct: 1222 PVGVNKAAPAPPVEDVSM---RIYLCEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELNHIKKCNTVK-GVFVLE 1533 HSP 3 Score: 62.7734 bits (151), Expect = 4.402e-9 Identity = 32/113 (28.32%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 915 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEI-NRKVYKGMLDILKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 1026
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Match: BX119977.1 (MAP-kinase activating death domain [Source:NCBI gene;Acc:100150917]) HSP 1 Score: 493.041 bits (1268), Expect = 5.171e-147 Identity = 262/605 (43.31%), Postives = 376/605 (62.15%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER--RSPIKVTRVXXXXXXXXXXXXXXXFQG--GRESMSRQSKRIRP--RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRR-----SNGKDSIWPTLLGS-SVE--NTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQ-----------ALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G RYGICLNF+R ++ P + + + G G+ S++S RI P R LTSL I+SH+P F F+ CL ILK +++ +R+ +R S +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG R+++ +LP L + FALPD RF +VDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF L + FKMP DVW DLD +++ +N +++P + + L KH+KQ + + AL S+S ++P+ NL++ + EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F +KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 2 MEKKKMCPRLLDYLVVVGARQP--SNDSVAQTPQLLRRYPLEDHNDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDTSFVFTLTDKDSGITRYGICLNFYRSFQKAHHRPRAEGKGEHSAPPAGDGTLLPGEPGSSGKSPRSKRSGRIAPQNRNSMLTSLCILSHYPFFSTFRECLYILKRMVDCCSQRLNQRPGAPKSTQRDTMWRVFTGALSVEEKEKGSQVLQDLREIESWVYRLLRSPVPVAGQRRVDVEVLPHELQPALTFALPDPSRFSIVDFPLHLPLELLGVDACLQVLACILLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYVIGVPASFFLYKCDFKMPDDVWLVDLDCNKVIVPSNAELLPPLPE---------PEASELKKHLKQVNAADVLISLRSPTINCALASMSLNTQPILNLEKFQDGQELSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRNGFTEKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 595 HSP 2 Score: 202.601 bits (514), Expect = 1.022e-51 Identity = 111/289 (38.41%), Postives = 164/289 (56.75%), Query Frame = 2 Query: 3674 PVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 PV N VE SM R+YL + L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+MM+V I+ K R ++GKSHI L S IN+++D + +L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1161 PVGVNKAAPAPPVEDVSM---RIYLCEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMMKVGKNDIRKKVRRLMGKSHIGLTHSQEINEVLDRLAHLSGRELSIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINL 1445 HSP 3 Score: 62.7734 bits (151), Expect = 5.039e-9 Identity = 32/113 (28.32%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 922 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDAQQEVIRDVEI-NRKVYKGMLDILKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 1033
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Match: madd (MAP-kinase activating death domain [Source:NCBI gene;Acc:780174]) HSP 1 Score: 504.212 bits (1297), Expect = 4.953e-150 Identity = 272/598 (45.48%), Postives = 372/598 (62.21%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRE------------SMSRQSKRI-----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLK-PSQSE---ISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL I+G R P S S PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G +RYGIC+NF+R ++R P +R + S GG + S + KR+ R R +LTSL I+SH+P F F+ CL LK +++ ER+ + G +D++W GS +E +V+ HD+ EIE WI+RLL SP PV G R+++ +LP P+ FALPD RF LVDFPLH EL+GVE L++ ++LE+KV++QS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +K+V TN D LP P + + L KH+KQAL S+S ++P+ NLD + LK PS ++ + FNPLI+GND DSVDV+TRVAMVRFFNS ++L ++ TR L+L+PRP+VAFQ +F+ +R S F +KLSKTQAV+FF EW++ P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIIGARQP--SSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGS---DGGHPMQPHSAESTPDINQSPRGKRLSKGMQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVDCCSERLVSKKAGVTKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPDPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVMQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLD--------TNKVVAPTNADLLPVLPEP-EASELKKHLKQALA------SMSLNTQPILNLDRFHEGPDAALLKAPSDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHSFQMHTRTLRLFPRPVVAFQSSSFLAARPKPSLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDAN 585 HSP 2 Score: 211.846 bits (538), Expect = 2.429e-54 Identity = 113/314 (35.99%), Postives = 177/314 (56.37%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+MIMM+V+ ++ K R ++GK HI L S IN+L+D + + G D+ + + SR Q F V+ G D GD+ E+ DC++LRS GA+ RWW E+ I T K V+C+ RR E +++ + KK L H V +F V D T G L++ G+ ++ F+ ++++C T + F++E P TK + +K+ A+ I Sbjct: 1222 SQRIYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEDDEDRLLATLLHNMIAYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDRVTDMNGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKVTGLF-----HVYWLGQVGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVR-GVFVLEEFVPETKEVVSHKYKTPMAHEI 1528 HSP 3 Score: 57.3806 bits (137), Expect = 3.043e-7 Identity = 28/114 (24.56%), Postives = 63/114 (55.26%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 ENQ+ +++V +L+G ++ +++ ++E+E R +LS++N++++ + + I +V I + + ++ + + V+ +E +Y G SVF LE+ THY K+ Sbjct: 909 ENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEI-TRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFSLLEIAHTHYYNKE 1021
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Match: madd (MAP-kinase activating death domain [Source:NCBI gene;Acc:780174]) HSP 1 Score: 504.982 bits (1299), Expect = 7.611e-150 Identity = 272/598 (45.48%), Postives = 372/598 (62.21%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRE------------SMSRQSKRI-----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLK-PSQSE---ISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL I+G R P S S PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G +RYGIC+NF+R ++R P +R + S GG + S + KR+ R R +LTSL I+SH+P F F+ CL LK +++ ER+ + G +D++W GS +E +V+ HD+ EIE WI+RLL SP PV G R+++ +LP P+ FALPD RF LVDFPLH EL+GVE L++ ++LE+KV++QS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +K+V TN D LP P + + L KH+KQAL S+S ++P+ NLD + LK PS ++ + FNPLI+GND DSVDV+TRVAMVRFFNS ++L ++ TR L+L+PRP+VAFQ +F+ +R S F +KLSKTQAV+FF EW++ P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIIGARQP--SSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGS---DGGHPMQPHSAESTPDINQSPRGKRLSKGMQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVDCCSERLVSKKAGVTKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPDPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVMQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLD--------TNKVVAPTNADLLPVLPEP-EASELKKHLKQALA------SMSLNTQPILNLDRFHEGPDAALLKAPSDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHSFQMHTRTLRLFPRPVVAFQSSSFLAARPKPSLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDAN 585 HSP 2 Score: 211.46 bits (537), Expect = 3.058e-54 Identity = 114/340 (33.53%), Postives = 187/340 (55.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+MIMM+V+ ++ K R ++GK HI L S IN+L+D + + G D+ + + SR Q F V+ G D GD+ E+ DC++LRS GA+ RWW E+ I T K V+C+ RR E +++ + KK +EL +++ E+ + I+P +F V D T G L++ G+ ++ F+ ++++C T + F++E P TK + +K+ A+ I Sbjct: 1261 SQRIYLYEGLLGRDKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEDDEDRLLATLLHNMIAYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDRVTDMNGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKCRELYYCVKESMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVR-GVFVLEEFVPETKEVVSHKYKTPMAHEI 1599 HSP 3 Score: 57.3806 bits (137), Expect = 2.866e-7 Identity = 28/114 (24.56%), Postives = 63/114 (55.26%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 ENQ+ +++V +L+G ++ +++ ++E+E R +LS++N++++ + + I +V I + + ++ + + V+ +E +Y G SVF LE+ THY K+ Sbjct: 927 ENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEI-TRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFSLLEIAHTHYYNKE 1039
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Match: madd (MAP-kinase activating death domain [Source:NCBI gene;Acc:780174]) HSP 1 Score: 504.597 bits (1298), Expect = 7.747e-150 Identity = 272/598 (45.48%), Postives = 372/598 (62.21%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRE------------SMSRQSKRI-----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLK-PSQSE---ISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL I+G R P S S PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G +RYGIC+NF+R ++R P +R + S GG + S + KR+ R R +LTSL I+SH+P F F+ CL LK +++ ER+ + G +D++W GS +E +V+ HD+ EIE WI+RLL SP PV G R+++ +LP P+ FALPD RF LVDFPLH EL+GVE L++ ++LE+KV++QS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +K+V TN D LP P + + L KH+KQAL S+S ++P+ NLD + LK PS ++ + FNPLI+GND DSVDV+TRVAMVRFFNS ++L ++ TR L+L+PRP+VAFQ +F+ +R S F +KLSKTQAV+FF EW++ P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIIGARQP--SSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGS---DGGHPMQPHSAESTPDINQSPRGKRLSKGMQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVDCCSERLVSKKAGVTKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPDPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVMQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLD--------TNKVVAPTNADLLPVLPEP-EASELKKHLKQALA------SMSLNTQPILNLDRFHEGPDAALLKAPSDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHSFQMHTRTLRLFPRPVVAFQSSSFLAARPKPSLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDAN 585 HSP 2 Score: 204.527 bits (519), Expect = 4.363e-52 Identity = 112/334 (33.53%), Postives = 178/334 (53.29%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+MIMM+V+ ++ K R ++GK HI L S IN+L+D + + G D+ + + SR Q F V+ G D GD+ E+ DC++LRS GA+ RWW E+ I T K V+C+ RR E +++ + KK L H V +F V D T G L++ G+ ++ F+ ++++C T + F++E P TK + +K+ A+ I Sbjct: 1258 SQRIYLYEGLLGRDKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEDDEDRLLATLLHNMIAYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDRVTDMNGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKVTGLF-----HVYWLGQVGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVR-GVFVLEEFVPETKEVVSHKYKTPMAHEI 1585 HSP 3 Score: 57.3806 bits (137), Expect = 2.862e-7 Identity = 28/114 (24.56%), Postives = 63/114 (55.26%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 ENQ+ +++V +L+G ++ +++ ++E+E R +LS++N++++ + + I +V I + + ++ + + V+ +E +Y G SVF LE+ THY K+ Sbjct: 927 ENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEI-TRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFSLLEIAHTHYYNKE 1039
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Match: madd (MAP-kinase activating death domain [Source:NCBI gene;Acc:780174]) HSP 1 Score: 502.671 bits (1293), Expect = 1.414e-149 Identity = 273/611 (44.68%), Postives = 374/611 (61.21%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRE------------SMSRQSKRI-----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVC-------------QALNSISDKSEPVKNLDEVLNNVELQPLK-PSQSE---ISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL I+G R P S S PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G +RYGIC+NF+R ++R P +R + S GG + S + KR+ R R +LTSL I+SH+P F F+ CL LK +++ ER+ + G +D++W GS +E +V+ HD+ EIE WI+RLL SP PV G R+++ +LP P+ FALPD RF LVDFPLH EL+GVE L++ ++LE+KV++QS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +K+V TN D LP P + + L KH+KQ L +AL S+S ++P+ NLD + LK PS ++ + FNPLI+GND DSVDV+TRVAMVRFFNS ++L ++ TR L+L+PRP+VAFQ +F+ +R S F +KLSKTQAV+FF EW++ P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIIGARQP--SSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGS---DGGHPMQPHSAESTPDINQSPRGKRLSKGMQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVDCCSERLVSKKAGVTKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPDPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVMQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLD--------TNKVVAPTNADLLPVLPEP-EASELKKHLKQCLHSMSVITQQRLLASDNKALASMSLNTQPILNLDRFHEGPDAALLKAPSDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHSFQMHTRTLRLFPRPVVAFQSSSFLAARPKPSLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDAN 604 HSP 2 Score: 210.69 bits (535), Expect = 4.372e-54 Identity = 114/340 (33.53%), Postives = 187/340 (55.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+MIMM+V+ ++ K R ++GK HI L S IN+L+D + + G D+ + + SR Q F V+ G D GD+ E+ DC++LRS GA+ RWW E+ I T K V+C+ RR E +++ + KK +EL +++ E+ + I+P +F V D T G L++ G+ ++ F+ ++++C T + F++E P TK + +K+ A+ I Sbjct: 1182 SQRIYLYEGLLGRDKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEDDEDRLLATLLHNMIAYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDRVTDMNGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKCRELYYCVKESMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVR-GVFVLEEFVPETKEVVSHKYKTPMAHEI 1520 HSP 3 Score: 56.9954 bits (136), Expect = 4.118e-7 Identity = 28/113 (24.78%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++E+E R +LS++N++++ + + I +V I + + ++ + + V+ +E +Y G SVF LE+ THY K Sbjct: 932 ENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEI-TRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFSLLEIAHTHYYNK 1043
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Match: madd (MAP-kinase activating death domain [Source:NCBI gene;Acc:780174]) HSP 1 Score: 503.056 bits (1294), Expect = 1.503e-149 Identity = 273/611 (44.68%), Postives = 374/611 (61.21%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRE------------SMSRQSKRI-----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVC-------------QALNSISDKSEPVKNLDEVLNNVELQPLK-PSQSE---ISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL I+G R P S S PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK++G +RYGIC+NF+R ++R P +R + S GG + S + KR+ R R +LTSL I+SH+P F F+ CL LK +++ ER+ + G +D++W GS +E +V+ HD+ EIE WI+RLL SP PV G R+++ +LP P+ FALPD RF LVDFPLH EL+GVE L++ ++LE+KV++QS++YN LS S++A +++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +K+V TN D LP P + + L KH+KQ L +AL S+S ++P+ NLD + LK PS ++ + FNPLI+GND DSVDV+TRVAMVRFFNS ++L ++ TR L+L+PRP+VAFQ +F+ +R S F +KLSKTQAV+FF EW++ P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIIGARQP--SSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGS---DGGHPMQPHSAESTPDINQSPRGKRLSKGMQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVDCCSERLVSKKAGVTKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPDPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVMQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLD--------TNKVVAPTNADLLPVLPEP-EASELKKHLKQCLHSMSVITQQRLLASDNKALASMSLNTQPILNLDRFHEGPDAALLKAPSDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHSFQMHTRTLRLFPRPVVAFQSSSFLAARPKPSLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDAN 604 HSP 2 Score: 211.075 bits (536), Expect = 4.021e-54 Identity = 114/340 (33.53%), Postives = 187/340 (55.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+MIMM+V+ ++ K R ++GK HI L S IN+L+D + + G D+ + + SR Q F V+ G D GD+ E+ DC++LRS GA+ RWW E+ I T K V+C+ RR E +++ + KK +EL +++ E+ + I+P +F V D T G L++ G+ ++ F+ ++++C T + F++E P TK + +K+ A+ I Sbjct: 1200 SQRIYLYEGLLGRDKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEDDEDRLLATLLHNMIAYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDRVTDMNGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKCRELYYCVKESMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVR-GVFVLEEFVPETKEVVSHKYKTPMAHEI 1538 HSP 3 Score: 57.3806 bits (137), Expect = 3.178e-7 Identity = 28/114 (24.56%), Postives = 63/114 (55.26%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 ENQ+ +++V +L+G ++ +++ ++E+E R +LS++N++++ + + I +V I + + ++ + + V+ +E +Y G SVF LE+ THY K+ Sbjct: 932 ENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEI-TRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFSLLEIAHTHYYNKE 1044
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Match: Madd (MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]) HSP 1 Score: 506.138 bits (1302), Expect = 8.478e-155 Identity = 277/632 (43.83%), Postives = 383/632 (60.60%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXX----XXXXXXXXXXXXXFQGGRESMS-----------------RQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + S A G ES S R +R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 61.2326 bits (147), Expect = 1.537e-8 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 911 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1050
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Match: Madd (MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]) HSP 1 Score: 509.605 bits (1311), Expect = 8.891e-153 Identity = 277/632 (43.83%), Postives = 383/632 (60.60%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXX----XXXXXXXXXXXXXFQGGRESMS-----------------RQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + S A G ES S R +R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 204.527 bits (519), Expect = 2.874e-52 Identity = 103/270 (38.15%), Postives = 162/270 (60.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S +N+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1194 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINL 1462 HSP 3 Score: 60.077 bits (144), Expect = 3.572e-8 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 868 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1007
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Match: Madd (MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]) HSP 1 Score: 509.99 bits (1312), Expect = 3.472e-152 Identity = 277/632 (43.83%), Postives = 383/632 (60.60%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXX----XXXXXXXXXXXXXFQGGRESMS-----------------RQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + S A G ES S R +R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 196.823 bits (499), Expect = 6.878e-50 Identity = 102/290 (35.17%), Postives = 163/290 (56.21%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S +N+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1256 SQRVYLYEGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINL 1545 HSP 3 Score: 60.077 bits (144), Expect = 3.765e-8 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 911 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1050
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Match: Madd (MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]) HSP 1 Score: 509.22 bits (1310), Expect = 3.783e-152 Identity = 277/632 (43.83%), Postives = 383/632 (60.60%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXX----XXXXXXXXXXXXXFQGGRESMS-----------------RQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + S A G ES S R +R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 216.468 bits (550), Expect = 6.454e-56 Identity = 113/320 (35.31%), Postives = 186/320 (58.13%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S +N+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1194 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1511 HSP 3 Score: 59.6918 bits (143), Expect = 4.373e-8 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 868 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1007
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Match: Madd (MAP-kinase activating death domain [Source:MGI Symbol;Acc:MGI:2444672]) HSP 1 Score: 509.605 bits (1311), Expect = 3.941e-152 Identity = 277/632 (43.83%), Postives = 383/632 (60.60%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXX----XXXXXXXXXXXXXFQGGRESMS-----------------RQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + S A G ES S R +R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAAAGSSESGSTLQPPSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 216.468 bits (550), Expect = 6.955e-56 Identity = 113/320 (35.31%), Postives = 186/320 (58.13%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L GK +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S +N+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1215 SQRVYLYEGLLGK-ERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1532 HSP 3 Score: 59.6918 bits (143), Expect = 5.017e-8 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 888 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1027
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Match: sp|Q80U28|MADD_MOUSE (MAP kinase-activating death domain protein OS=Mus musculus OX=10090 GN=Madd PE=1 SV=2) HSP 1 Score: 509.605 bits (1311), Expect = 4.314e-151 Identity = 274/632 (43.35%), Postives = 380/632 (60.13%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQ----GGRESMS---------------------RQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + + G ES S R R R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + D+ EIE WI+RLL SPVPV+G R+++ +LP+ L + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + +++SD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKVEGGAGPRGKEGAHTSGASEEAATGSSESGSTLQPPSADSTPDINQSPWGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLQDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDGNSQLAEALSVPPERDSDSD 615 HSP 2 Score: 196.823 bits (499), Expect = 4.807e-49 Identity = 102/290 (35.17%), Postives = 163/290 (56.21%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S +N+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1275 SQRVYLYEGLLGRDKGSMWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQVNEVLDQLNSLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINL 1564 HSP 3 Score: 60.077 bits (144), Expect = 2.662e-7 Identity = 35/141 (24.82%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 931 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1070
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Match: sp|O08873|MADD_RAT (MAP kinase-activating death domain protein OS=Rattus norvegicus OX=10116 GN=Madd PE=1 SV=1) HSP 1 Score: 508.064 bits (1307), Expect = 2.406e-150 Identity = 267/633 (42.18%), Postives = 376/633 (59.40%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRP-------------------------RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSS-VENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQ-------SEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD 1948 M + CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R P + + + S ++P R +LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ + + + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E PL + + + FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N L + ++ESD Sbjct: 1 MVQKKFCPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKAEGGAGPRGKEGAHAPCASEEAATESSESGSTLQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQE-TPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESD 615 HSP 2 Score: 208.379 bits (529), Expect = 1.491e-52 Identity = 112/340 (32.94%), Postives = 187/340 (55.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSH+ L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1234 SQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1572 HSP 3 Score: 57.7658 bits (138), Expect = 1.166e-6 Identity = 34/141 (24.11%), Postives = 70/141 (49.65%), Query Frame = 2 Query: 2645 KDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 + + S ENQ+ +++V +L G ++ +++ ++E+E R +LS++++ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 911 QGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDARQDVIQDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKD 1050
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Match: sp|Q8WXG6|MADD_HUMAN (MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2) HSP 1 Score: 498.049 bits (1281), Expect = 1.600e-146 Identity = 269/608 (44.24%), Postives = 370/608 (60.86%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR-----------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHS--------LTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPL--KPS---QSEISG-FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 CPRL+DYL IVG R+P S + PELLRRYP DH LP DVV+FCQP+GC+S R + +D +FVFTLTDK+TG RYGIC+NF+R ++R + S S + + QS R + R + LTSL ++SH+P F F+ CL LK +++ ER+ + G +D++W GS VE +S + HD+ EIE WI+RLL SPVPV+G R+++ +LP+ L + FALPD RF LVDFPLH EL+GV+ L++ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ N +++P LP P L KH+KQAL S+S ++P+ NL++ E+ L +PS QS S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR Q+ F +KL++TQAV++F EW + P N F +I + +DP LIGDK KW+ L+PI+++VY N Sbjct: 8 CPRLLDYLVIVGARHP--SSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLP--------ILPEPESLE-LKKHLKQALA------SMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSN 598 HSP 2 Score: 208.764 bits (530), Expect = 1.094e-52 Identity = 113/340 (33.24%), Postives = 187/340 (55.00%), Query Frame = 2 Query: 3731 NQRMYLFQKLTGKN--------------------DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +QR+YL++ L G++ +RS +WD M FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N I++M++M+V+ I+ K R ++GKSHI L S IN+++D + L G D+ + ++ SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR +E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ + F++ ++++C T + F++E P K + +K+ A+ I Sbjct: 1279 SQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVR-GVFVLEEFVPEIKEVVSHKYKTPMAHEI 1617 HSP 3 Score: 58.5362 bits (140), Expect = 7.248e-7 Identity = 34/133 (25.56%), Postives = 67/133 (50.38%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTND 3067 ENQ+ +++V +L G ++ +++ ++E+E R +LS++N+ ++ + ++ I DV I S + ++ + + V +E SY G S+F LE+ THY K+ S + +PV D Sbjct: 940 ENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI-SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKD 1071
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Match: sp|O02626|MADD_CAEEL (MAP kinase-activating death domain protein OS=Caenorhabditis elegans OX=6239 GN=aex-3 PE=1 SV=1) HSP 1 Score: 437.573 bits (1124), Expect = 5.849e-127 Identity = 243/593 (40.98%), Postives = 340/593 (57.34%), Query Frame = 2 Query: 182 ICPRLIDYLSIVGLRNPNRSGHKNS---------VVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTS--RNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIK--VTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTH-SLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLP--PPADFNILIKHIKQALKVCQALNSIS----DKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 ICPRLID+L +VG RN R ++S PE+LRRYP DHK+ LP DV FCQP+GC +T +NA D FVF LT+K++ +VRYGICLNF++ +RRS K + +V + + KR +H SLTSL +SHHP F L +LK II+ + R +R+ KD +W L G E + ++ EIETWI LLSSPVPV G T++++ ++P L + FALPD+ RF L+DFPLH FE++G++ AL++ A +LE K+++QS+NYN +S IL++ ALLYPLEYMFP+ LLP +MPSAEQL AP+PF+ G+PSSF RK ++PSDV DLD L + +DL +P P D H+K+ LK A+N ++ D V + D FG D DSVDV+ RVAMV+FFNS ++ GN+++ TR L+LYPRP+V+ Q D+F++SR + + L +TQAV++F E + PKN F ++ + +GDK KWF +SL P++F VY N + Sbjct: 8 ICPRLIDFLVVVGKRNRTRGASQSSPDATTDTTVTYPEILRRYPTDDHKDFILPTDVTVFCQPEGCTTTSARLRKNARNDPQFFVFMLTEKDSAKVRYGICLNFYQSFDRRSTPKDEIKKVPDD--------------------AHHKKR---DSHVSLTSLCFISHHPFVSIFHQVLLLLKRIIDSSNHRAAQRTGLKDVVWAILTGHYNEPIVPEVMKEIKEIETWILMLLSSPVPVPGKTKVQIEVMPMDLSQVFEFALPDHTRFTLIDFPLHIPFEILGIDMALRVLTAAMLEFKIVIQSRNYNAVSMCILSIVALLYPLEYMFPVIPLLPAYMPSAEQLLLAPTPFLIGVPSSFFHHRKIRELPSDVILVDLDTNCL------------QVPDDLYIPDLPEPDAT----HLKERLK--NAINKMTTMTVDNETSVTDAD-------------------------FGIDIDSVDVACRVAMVQFFNSANVFGNFSEHTRTLRLYPRPVVSLQTDSFLRSRPQCTQLITDLCRTQAVEYFAECCLCPKNETFVRVQAGIESAEQVGDKPKWFSESLMPVHFMVYPNNST 534 HSP 2 Score: 196.052 bits (497), Expect = 7.743e-49 Identity = 109/318 (34.28%), Postives = 176/318 (55.35%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQ----AIQKHSEKFRSVIEPDT--SQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R Y++Q+L + +IW N+ FWE+ F D V QEREI+G+DQ+ +++DRY+ L+ +EK+RLE EDRLL +L+N A+MIM ++ K R ++GK+HI L S INKL+D + +GN + L SR Q F V G G + E+ D ++LRSI+GA RWW ER + T K ++C+ RR +++V M + + KK +EL Q A+++ + + + +E +F V D T G L++ +G+ + F+ N+++C T + F++E D + R + S A+ I Sbjct: 1071 RHYIYQELILAV-QHQIWQNLQFWENAFVDLVAQEREIVGMDQEPSEMIDRYSALNDSEKKRLELEEDRLLSTLLHNMTAYMIMCGTGQKALQQKVRRLLGKAHIGLVCSKEINKLLDELPSTQGNFIPLKPLGSRLVQKQSFTVCPGQSSDGQMMFMEVCDDAVVLRSITGAATERWWYERLVNITYSPKTKILCLWRRHDDKVHMHKFHTKKCRELYQCMKAAMERAAARGKVNVEGRALGGEFPVHDTETNQGGLLQVRCDGVAVIFAHNQIFIGLSNIKKCNTFGGNVFLLEEFDRKKGEIIQRRYFSQMADQI 1387 HSP 3 Score: 76.6406 bits (187), Expect = 2.178e-12 Identity = 50/171 (29.24%), Postives = 92/171 (53.80%), Query Frame = 2 Query: 2507 QEILKSNPTYKPISER--KPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKG 3013 Q I K+ P + + ER KP L N+++++ R + + + + +NQ+T+++ D+ L G + + S ++K ++E+E+ R L+ S++N LE ++ ++ Y+ +V + ++ F A V I + + GIE S+N C GF SVF LE+ THY G Sbjct: 733 QVINKTAPKAQALKERTMKP------LANRIEQSQHIVRSKTQPNPTSQQTANQQSKNQQTVKEFCDQALVGQSVGMFSAPKLKRLMEDESLRELVCSKLNLGLEVKLS-EDEYVKEVQL-TKGQFKAYVKILKACLEGIEVSFNTPGCCGFASVFHVLEIAHTHYWAMGG 895
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Match: sp|Q9VXY2|MADD_DROME (MAP kinase-activating death domain protein OS=Drosophila melanogaster OX=7227 GN=Rab3-GEF PE=2 SV=2) HSP 1 Score: 404.445 bits (1038), Expect = 2.013e-113 Identity = 236/578 (40.83%), Postives = 339/578 (58.65%), Query Frame = 2 Query: 557 GGRESMSRQS--KRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG------KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALN----------SISD--KSEPVKNLDEVLNNVELQP-------------------LKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISEC---------------QRLT--VDPTKIYYPPTYLQIP 2122 GG S S ++ KR + R SLTSL I+SHHP F F+ CL ILK++I+ +E + G +D++W L G + T S++ HDV EIETWI RLLS+PVPV G TR+E+ +L T+ +P++FALPD+ RF LVDFPLH EL+GVE LK++ ++ ENKV+ QS++YN LS S++A +LYPLEYMFP+ LLPT + AEQL AP+PF+ G+P+SFL+ +K+F++P D+W DLD + K+ P T ++ P + IL H+KQAL A N S+ D + P+ + +V ++ P +PS NP ++G D DSVDV+TRVAMVRFFN+Q+ L N+ + TR L+LYPRP+VAFQ+++F++SR S F+ + ++TQAV+F EW++ P N F ++ + DP +GDK KWF +L PI F V+ + S L + + PTDESGSDS+ SSSS L++ S++A S +S Q L+ +DP +Y+PP+ LQ P Sbjct: 238 GGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLD--------STKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQ---PTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYP 804 HSP 2 Score: 228.409 bits (581), Expect = 1.550e-58 Identity = 119/314 (37.90%), Postives = 183/314 (58.28%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIE-PD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R+YLF+ L GK DR +W+ M FWED F DAV QER++IG+DQ ++M+RY L +E++RLE +EDRLL +L N A ++M+ V +I+ K R ++GKSHI L S ++ ++D I L GND+DL SR Q F V+ G D G + E+ D ++LRS+ G I RWW ER + T K ++C+ RR + + + Y +K KEL I++ E+ + P+ +F V D T G L++ G+ N+ +FV ++R+CFT+K F++E +P T+NL R ++S ++ I Sbjct: 1452 RVYLFEGLLGK-DRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQI 1764 HSP 3 Score: 123.635 bits (309), Expect = 1.379e-26 Identity = 57/109 (52.29%), Postives = 75/109 (68.81%), Query Frame = 2 Query: 179 SICPRLIDYLSIVGLRN--PNRSGHKN-----SVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSR--NAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER 478 S+CPRL+DY++IVG P G + VP+LLRRYP +DH + LP D+VYFCQP+GC S R +A +D +FVF LTDK++G+ RYGIC+NF+RPIER Sbjct: 8 SLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIER 116 HSP 4 Score: 73.1738 bits (178), Expect = 2.630e-11 Identity = 44/164 (26.83%), Postives = 87/164 (53.05%), Query Frame = 2 Query: 2519 KSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKK 3010 KS + P RK ++ER+ LI K + + + +++ + ENQ ++ VT+++L G + R K ++E+E+YR L+LS++NK L+K I + +I+DV + ++ + ++ + + G++ ++ G SVF +E+ THY K+ Sbjct: 1139 KSGINFDPFPGRKGLVERTPLI---KHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKI-APDDHIDDVCV-TKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKE 1297
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Match: R7VC38 (UDENN domain-containing protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_182066 PE=4 SV=1) HSP 1 Score: 564.688 bits (1454), Expect = 2.451e-176 Identity = 316/690 (45.80%), Postives = 448/690 (64.93%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVV--PELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQG-------GRESMSRQSKR-----IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDER-IKRRSNG-----KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALK--VCQA------LNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESD-CPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGIS-------ECQRLTVDPTKIYYPPTYLQIPSINIIESE 2146 CPRL+DY+ IVG RNP+R+ NSV PELLRRYP DHK+ AL DVV+FCQP+GCI+ R + ++ +FVF+LT+K+TGR RYGICLNF+R E+R + ++S++ S G G + S ++KR R R ++LTSL ++SHHP F F+ CL +L+++I+ +ER RR G +D++W + G ++T S++ H+V EIETWI RLLS+PVPV G T++E+++LP+ L +PV+F+LPD+ RF LVDFPLH EL+GV+ +K+ ++LE+K+ILQS++YN LS S++A +LYPLEYMFP+ LLPT M SAEQL AP+PFI G+P+SFL+ ++ F +P DVW DLD ++K++P +N D LP P + +L H+KQ K C L+ + +P+KNL+ + N ++ + S + GFNPLI+GND DSVDV+TRVAMVRFFNS +IL N+T+ TR L+LYPRP+VAFQ+++F KSR +++ F KL++ QAV+FF EW ++P N VF +I + YDP LIGDK KWF L+ I+FKVY E S + + SD PTDESGSDSD +SSS L++ D+ +S I+ E Q LTVD ++++ PP+ LQ+P I S+ Sbjct: 6 CPRLLDYIVIVGSRNPSRN---NSVAQTPELLRRYPVEDHKDFALAPDVVFFCQPEGCINVGPKRMSLRESTSFVFSLTEKDTGRTRYGICLNFYRSFEKRPTYAANKAERHTSIASSASTSSGEHGVLHPPAPGDPNRSPRAKRKQKVQGRVRNNTLTSLCLISHHPFFSTFRECLFVLRKLIDSCNERSCSRRIGGSRAGTRDTVWGVITGQHSDSTPSLVMHEVREIETWILRLLSAPVPVPGRTKVEITVLPKELHQPVMFSLPDHTRFSLVDFPLHLPLELLGVDLCMKVLTLIMLEHKLILQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCMSSAEQLLLAPTPFIIGVPTSFLMYKRGFMLPDDVWLIDLD--------SNKILPPSNADELPPLPEP-EGTVLKNHLKQVGKSLYCHTSMLLLYLSDVHAGPQPIKNLETIAQNPDVWKRRSSFTSTQGFNPLIYGNDVDSVDVATRVAMVRFFNSPNILANFTEHTRTLRLYPRPVVAFQLNSFFKSRPIKTVFTAKLARAQAVEFFAEWALSPANVVFQRIQTGVYDPLLIGDKGKWFSHGLQKIDFKVYDEATSTLGPAIATAVESRGSDENPTDESGSDSDGAESTSSSYSSLSDFVIDIQNSEINAFVEIYPEDQVLTVDESRVFSPPSALQVPDTPISNSD 683
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Match: A0A2T7PJ46 (UDENN domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_04707 PE=4 SV=1) HSP 1 Score: 572.392 bits (1474), Expect = 1.272e-171 Identity = 331/769 (43.04%), Postives = 466/769 (60.60%), Query Frame = 2 Query: 188 PRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPI-----KVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDER--IKR----RSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPAD-----FNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGIS--------ECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNS 2422 PRL+DYL I G R+PN + H S PELLRRYP DHK+ ALP DV++FCQP+GCIS R + ++ +FVFTLT+K++G VRYG+C+NF+RP E+R KV R S S + S R +R+ R+R T LTSL I+SHHP F F+ CL IL+ +IE +R ++R ++ +D++W L G + EN ++++ H+V EIETWI RLLS+PVPV G TR+E+++LP+ L P++FALPD+ RF LVDFPLH EL+GV+ LK+ A++LE+KVILQS++YN L+ S++A ++LYPLEYMFP+ LLPT M SAEQL AP+PF+ G+P+SF ++ F +P D+W DLD N ++ PP AD +K LK QAL S+S +P+KNLD + N E+ + S S +GFNPLI+GND DSVDV+TRVAMVRFFNS +ILGN+T+ TR L+LYPRP+VAFQ+ +F+KSR ++ F +L++TQAV++F EW++ P N V+ ++ + YDP LIGDK KW+ Q L+P+ F VY +N S + + D PTDESGSDS+ +SSS L++ +++ +S I E Q L VD K++ PP L +P S DS F ++ +S+ +S H++ K S++ K F YD+ N T T+ + + +T L GS S S Sbjct: 9 PRLLDYLVIAGSRHPNSNNHV-SQTPELLRRYPLEDHKDFALPNDVIFFCQPEGCISVGPKRMSLRETTSFVFTLTEKDSGIVRYGVCVNFYRPFEKRMHSSECWQKVDRSSTGSTHSVETLSSSECDRPRSPRARRKSRVRNNT--LTSLCIISHHPFFSTFRECLFILRRLIEACHDRSCVRRVGGSKATARDTVWGVLTGQTSENISTLVMHEVREIETWILRLLSAPVPVPGKTRVEVNVLPKELQAPLLFALPDHTRFSLVDFPLHLPLELLGVDTCLKVLTAIMLEHKVILQSRDYNALTMSVMAFVSMLYPLEYMFPVIPLLPTCMASAEQLLLAPTPFLIGVPASFFRYKRDFPLPDDIWIVDLDA------------------NKITSPPNADPLPPLPEPECTGLKTHLK--QALASMSMTPQPIKNLDAIAQNPEMWQRRESFSSQTGFNPLIYGNDVDSVDVATRVAMVRFFNSPNILGNFTEHTRTLRLYPRPVVAFQLYSFMKSRPQRTHFTARLARTQAVEYFAEWSLCPNNLVYQRVQTAVYDPSLIGDKPKWYAQHLQPVEFHVY-DNSSSLAAAITSVSETLSDDIPTDESGSDSEGAESTSSSYSSLSDLIAEMTNSEIDGETPSFVPENQILAVDEAKVFCPPDKLHVPEAPSTNS--DSAFSLQEDSDMSSSESSSAASS---------PEPHDVQTK-------DSEEHKIFR----YDSGNITETTYSLSSMSRTDLPGSPHSPRS 731 HSP 2 Score: 233.802 bits (595), Expect = 5.787e-58 Identity = 117/280 (41.79%), Postives = 173/280 (61.79%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRS-----VIEPD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFV 4552 + YLF+ L K DRS++WD M FWED+F DAV QER+IIG+DQ ++M+RYN L EK+RLE++EDRLL ++L N + FM+MMRV ++K K R ++GKSHI L S ++N L+D I +L+GND+DL SRQ Q F V+ G D GD+ E+ DC+LLR+++G I+ RWW E+ + T K V+C+ R+ +V ++Q Y KK +EL ++++ EK S + P+ +F V D + G L++ G+ N+ FV Sbjct: 1259 KTYLFEGLIAK-DRSRMWDQMQFWEDMFLDAVAQERDIIGMDQRPSEMMERYNSLGDTEKKRLEQDEDRLLSVMLYNLVGFMLMMRVPKAEVKKKVRRLLGKSHIGLHHSQDVNNLLDVITHLQGNDIDLKPMGSRQMQKQSFTVHWGTDNTGDMLFMEVCDDCLLLRNVTGMIHDRWWFEKLVNMTYCPKTKVLCLWRKNGEKVQLNQFYTKKCRELYFSVKEAMEKAASRTTGRIPGPELGGEFPVQDLKSGQGGLLQVCMEGIGLLLANSKASTCFV 1537 HSP 3 Score: 80.8777 bits (198), Expect = 2.946e-11 Identity = 45/158 (28.48%), Postives = 87/158 (55.06%), Query Frame = 2 Query: 2525 NPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHY 2998 N + P+ RK ++E+S L+ K A + +R + + S + ENQ+ +++V + +L G + + RIK ++E+E YRN ++SR+N+NL+K + +I DV + S F ++ + + +++G+E + G S ++ LE+ THY Sbjct: 855 NKPFTPLGNRKALVEKSGLV---KHATNIKQRDQPKPTAAEPRGSTNSENQQFLKEVINGVLDGQGVSWLKISRIKKLMEDENYRNFVVSRLNRNLDKKVPEDARHIEDVCL-SRPVFKGMLGMCKAIISGLEHTIQNHGLGGMASAYMVLEIAHTHY 1008
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Match: A0A210Q284 (MAP kinase-activating death domain protein OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT17866 PE=4 SV=1) HSP 1 Score: 572.007 bits (1473), Expect = 1.036e-170 Identity = 305/684 (44.59%), Postives = 440/684 (64.33%), Query Frame = 2 Query: 182 ICPRLIDYLSIVGLRNPNRSGHKNSVV--PELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQG-GRESMSRQSKRI----RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDER--IKR----RSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGIS--------ECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIK 2170 +CPRL+DY+ +VG R+PN H N+V PELLRRYP DH + LP D+++FCQP+GCIS R + ++ +FVFTLT+K++G VRYGIC+NF+RPIE++ K + + + GR+ R S+R+ R R ++LTSL IVSHHP F F+ C+ IL+++I+ +R KR R + +D++W L G +N ++ H+V EIETWI RLLS+PVPV G TR+E+ +LP+ L P++FALPD+ RF L+DFPLH EL+GV+ LK+ A++LE KV++QS++YN LS S++A +LYP+EYMFP+ LLPT M SAEQL AP+P+I G+P+SFL + FK+P DVW DLD ++ + P P P + +L H++QAL S+S +P+KNLD + N + + S S +GFNPLI+GND DSVDV+TRVAM+RFFNS + LGN+T+ TR L+LYPRP+VAFQ+ +F+KSR ++ F +L+++QAV+++ EW++ PKN VF ++ + +DP LIGDK KW+ L+ + FKVY +N S + + D ++ D PTDESGSDSD +SSS L++ +D+ +S I E Q L+VD +K+Y PP L +P + S DS F ++ Sbjct: 9 LCPRLVDYIIVVGSRHPN---HNNNVAQTPELLRRYPLEDHHDFPLPPDIIFFCQPEGCISVGPKRMSLRETTSFVFTLTEKDSGLVRYGICVNFFRPIEKKYSEKSKSERFYGGNADGNTLGIGIESDGRQRSPRTSRRLKTAGRVRNNTLTSLCIVSHHPFFSTFRECMFILRKLIDSCHDRSCTKRIGGSRGSSRDTVWGVLTGQGTDNITGLVMHEVKEIETWILRLLSAPVPVPGKTRVEVQVLPKDLQPPLLFALPDHTRFSLIDFPLHLPLELLGVDTCLKVLAAIMLEYKVVMQSRDYNALSMSVMAFVTMLYPMEYMFPVIPLLPTCMSSAEQLLLAPTPYIIGVPASFLPYKNGFKVPDDVWLVDLDSNKMTMGKLEDIPP---------FPEP-EGTMLKNHLRQALA------SMSMTPQPIKNLDALAQNPDTMKRRESFSSQTGFNPLIYGNDVDSVDVATRVAMIRFFNSANTLGNFTEHTRTLRLYPRPVVAFQMYSFLKSRPARTHFTARLARSQAVEYYAEWSLCPKNVVFLRVQTSVFDPLLIGDKPKWYAHQLQSLEFKVYDDNSSLAAAVTSSMDLISD-DNPTDESGSDSDGAESTSSSYSSLSDFVTDMVNSEIDGDTLCFVPENQVLSVDESKVYTPPNKLHLPDTPVTTS--DSAFSMQ 670 HSP 2 Score: 244.202 bits (622), Expect = 4.086e-61 Identity = 126/333 (37.84%), Postives = 196/333 (58.86%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRS-----VIEPD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSAN----LIFRLFQSQVQKF 4699 RMYL++ L K DRS++WD M FWEDV+ DAV QER+IIG+DQ ++M+RYN L +EK+RLE++EDRLL +L N +FM+MMR + +++ K R ++GKSHI L S +++ ++D + GN++ L SR Q F V+ G D GD+ E+ DC++LRS+ GAI RWW E+ + T K V+C+ R+ +V ++Q Y KK +EL +++ EK + + P+ +F V D + G L++ G+ N+ F++ +++CFT+K F++E D + +T FKS AN +I R+F Q K Sbjct: 1277 RMYLYEGLVTK-DRSRLWDQMQFWEDVYLDAVAQERDIIGMDQGPGEMMERYNSLGDSEKKRLEQDEDRLLSTMLYNLASFMVMMRCNKQELRKKVRRLLGKSHIGLVYSQDVHTVLDLAMTMHGNEISLKPMGSRFMQKQSFTVHWGSDNSGDMLFMEVCDDCIILRSVMGAICDRWWYEKLVNMTYCPKTKVLCLWRKHGEKVQLNQFYTKKCRELYFCVKEAMEKAAARNNGKIAGPELGGEFPVQDLKSGQGGLLQVCMEGIGLLLANSKSFIELGRIKKCFTQKGGIFVLEEFDTKNRQVTLHKFKSRMANPIALMIHRIFAVQHAKM 1608 HSP 3 Score: 82.0333 bits (201), Expect = 1.687e-11 Identity = 66/261 (25.29%), Postives = 128/261 (49.04%), Query Frame = 2 Query: 2534 YKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSI-DYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISS----KNDINATHGV 3301 + P+ RK ++E+S L+ K A ++ ST D + + ENQ+ ++ + +L G + + RI+ ++E+E YRN ++SR+NKNL+K +N ++ D + ++ F ++ + + +V+G+E +Y G S F+ LE+ THY K+ + S+ + + VT + PY S++ + + Q + + L + + + G P+ +NGE +E IEI S + ++A H Sbjct: 875 FAPLGNRKALVEKSGLV---KHATPRKQKDSTKQTSSSDSRGASNSENQQFLKDIVTNVLDGQGVSWLKLGRIRRLMEDENYRNFMVSRLNKNLDKKLNDDTQHLEDASM-TKQVFKGMMTLMKAIVHGLEHTYQNHGIGGMASAFMVLEIAHTHYWAKE-IIQGTGSSNRSDTSVTPEINSPY-------GSHESLSSRSEGSPQKSESHSLHEEHMVAAL-------GSPVLVNGEEFENIEIQSMSLHQGSVDAGHAT 1116
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Match: V4ALC2 (UDENN domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_103875 PE=4 SV=1) HSP 1 Score: 563.148 bits (1450), Expect = 2.656e-168 Identity = 331/751 (44.07%), Postives = 469/751 (62.45%), Query Frame = 2 Query: 185 CPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRS-PIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRP--------RTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDER-IKRRSNG-----KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGIS---------ECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEM-NIKKREREVKRQHNLSNKRKSVDKNQSKDPK-------TFTTGNAYDT 2341 CPRL+DY+ I G RN + + + PELLRRYP DHK+ LP DV++FCQP+GCIS R + ++ +FVFTLT+K++G VRYGIC+NF+RP E+RS V + ER S +S ES +S R R R ++LTSL IVSHHP F F+ CL IL+ +I+ +R RR G +D++W L G +N S++ HDV EIETWI RLLS+PVPV G TR+E+ +LP+ L P++FALPDN RF L+DFPLH EL+GV+ LK+ AV+LE+KVILQS++YN LS S++A +LYPLEYMFP+ LLPT M SAEQL +AP+P++ G+P+SF L +K F +P D+W DLD ++K+ P + + SLP P + +L H+KQAL S+S +P+KNLD + N E+ + S S +GFNPLI+GND DSVDV+TRVAM+RFFNS +ILGN+ + TR L+LYPRP+VAFQ+ +F+KSR+V++ F +L++TQAV+++ EW+++P+N V+ ++ + YDP LIGDK KW+ L+ + F VY N S + L D ++ + PTDESGSDS+ +SSS L++ +D+ +S I E Q L VD +K++ PP L +P +N S DS + +S+ +S NI + ERE K ++ +V S+ P+ T +T +A+D Sbjct: 10 CPRLLDYIVITGSRN-PNNNNNVAQTPELLRRYPLEDHKDFPLPTDVIFFCQPEGCISVGPKRMSLRETTSFVFTLTEKDSGIVRYGICVNFFRPFEKRSHTTSVDWQNKERNSSLASTHSVDTVSSTESDKPKSPRARRKGGPSCRVRNNTLTSLCIVSHHPFFSTFRECLFILRRLIDACHDRSCVRRIGGSKGATRDTVWGVLTGQCSDNITSLVMHDVREIETWILRLLSAPVPVPGKTRVEVHILPKDLQAPLLFALPDNTRFTLIDFPLHLPLELLGVDTCLKVLTAVMLEHKVILQSRDYNALSMSVMAFVYMLYPLEYMFPVIPLLPTCMSSAEQLLSAPTPYLIGVPASFFLYKKGFLLPEDIWIVDLD--------SNKIHPPSKAEPLPSLPDP-EGAVLKTHLKQALA------SMSMTPQPIKNLDALAQNAEIWQRRESFSSQTGFNPLIYGNDVDSVDVATRVAMIRFFNSSNILGNFCEHTRTLRLYPRPVVAFQLYSFLKSRQVRTHFSVRLARTQAVEYYAEWSLSPQNLVYLRVHTGVYDPSLIGDKPKWYAHQLQSVEFHVYDPNSSLSAALNSVSDVLSD-EIPTDESGSDSEGAESTSSSYSSLSDFVTDMVNSEIDGETPAAFIPENQILAVDESKVFTPPDKLHVPDVNATNS--DSALSLPEDSDVSSSASSSPTYSDNIPRSEREDKDLEDIKILLGAVLPGPSEAPRSPKLPSFTKSTNSAFDV 741 HSP 2 Score: 254.218 bits (648), Expect = 2.924e-64 Identity = 127/314 (40.45%), Postives = 192/314 (61.15%), Query Frame = 2 Query: 3743 YLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRS-----VIEPD-TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSAN 4660 +LF+ L GK +RS++WD M FWEDVF DAV QER+IIG+DQ ++MDRY L E++RLE +ED++L +L N ++FM+M+RV+ +IK K+R ++GKSHI L S +N L+D I L GND+DL SRQ Q F V+ G D GD+ E+ DC+LLRS++G+I+ RWW E+ + T K V+C+ R+ +V ++Q Y KK KEL +++ EK + + P+ +F V D + G L++ G+ N+ +F++ ++R+CFT K F++E D K + FKS A+ Sbjct: 1194 FLFEGLLGK-ERSRLWDQMQFWEDVFLDAVAQERDIIGMDQSPSEMMDRYASLGDMERKRLEHDEDKILATILFNLVSFMVMLRVNKTEIKKKSRRLLGKSHIGLIHSQEVNNLLDQITMLHGNDIDLKPICSRQMQKQSFTVHWGTDNTGDMLFMEVCDDCLLLRSVTGSIHDRWWFEKLVNMTYCPKTKVLCLWRKNGEKVQLNQFYTKKCKELYFCVKEAMEKAAARNSGKLPGPELGGEFPVQDLKSGQGGLLQVCMEGIGLLLANSKFFIELAHIRKCFTLKGGIFVLEEFDTKNKKIIQHKFKSRMAD 1506 HSP 3 Score: 75.485 bits (184), Expect = 1.389e-9 Identity = 34/116 (29.31%), Postives = 71/116 (61.21%), Query Frame = 2 Query: 2651 KKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHY 2998 + S + ENQ+ ++ V + +++G + + R+K ++E+E YRN ++SR+NKNL+K + + +I+DV + S F ++ + + +++G+E ++ G S ++ LE+ THY Sbjct: 884 RSSSNSENQQFLKDVVNNVMEGQGTSWLKMGRVKTLMEDENYRNFVVSRLNKNLDKKVTDESLHIDDVCV-SRQVFKGMLAMLKAIIHGLEKTFQNHGLGGTASAYMVLEIAHTHY 998
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Match: A0A433TIA0 (UDENN domain-containing protein (Fragment) OS=Elysia chlorotica OX=188477 GN=EGW08_010917 PE=4 SV=1) HSP 1 Score: 550.436 bits (1417), Expect = 9.072e-168 Identity = 311/686 (45.34%), Postives = 424/686 (61.81%), Query Frame = 2 Query: 170 ANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPI-------KVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDER-IKRRSNG-----KDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLL--KHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTL-----------HLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGI--------SECQRLTVDPTKIYYPPTYLQIPS 2125 +N CPRL+DYL I G R PN ++ S PELLRRYP DHK+ LP DV++FCQP+GCIS R + ++ +FVFTLT+K++G VRYGIC+NF+RP E+R+ I KV + + S + S R S SR K+ R R ++LTSL IVSHHP F F+ CL IL+ +IE +R RR G +D++W L G + +N +S++ H+V EIETWI RLLS+PVPV G TR+E+ +LP+ L P++FALPDN RF LVDFPLH EL+GV+ L+ A++LE+KVILQS++YN LS S++A ++LYPLEYMFP+ LLPT M SAEQL AP+P++ G+P+SF +K F +P D+W DLD ++L K DL H+KQAL S+S +P+KNLD + N +L + S + ++ NPLI+GND DSVDV+TRVAMV+F NS + LGN+T+ TR L+LYPRP+VAFQ+ +F+KSR ++ F KL++TQAV+F EW++ P N V+ ++ + YDP LIGDK KW+ Q L+ ++F Y + S Q +T D PTDESGSDSD +SSS L++ SDL +S I E Q L VD +Y PP+ L +P Sbjct: 5 SNRYFCPRLLDYLVIAGCRFPN-GNNQMSQTPELLRRYPLEDHKDFPLPNDVIFFCQPEGCISVGPRRMSLRETTSFVFTLTEKDSGLVRYGICINFYRPFEKRAHIPSAEAWQKVDKSATGSSHSVETLSSSECDRPR-SPSRTRKKSRVRNNTLTSLCIVSHHPFFSTFRECLFILRRLIEACHDRSCVRRVGGSKATVRDTVWGVLTGQTSDNISSLVMHEVKEIETWILRLLSAPVPVPGKTRVEVHVLPKELQAPLMFALPDNTRFSLVDFPLHLPLELLGVDTCLRALTAIMLEHKVILQSRDYNALSMSVMAFVSMLYPLEYMFPVIPLLPTCMASAEQLLLAPTPYLIGVPASFFGYKKGFPLPDDIWVVDLDANKILPPKGAEPLPPLPEPEGTDLK-----------THLKQALA------SMSMTPQPIKNLDALAQNPDLWQRRDSLT-MTQRNPLIYGNDVDSVDVATRVAMVKFLNSPNTLGNFTEHTRTLRLYPRPVVAFQLYSFLKSRAERTAFTAKLARTQAVEFLSEWSLCPTNLVYQRVQTNVYDPSLIGDKPKWYAQQLQLVDFHAYDRDSSLGAAVASVVSAAQERAAGGQGGHTSDDGPTDESGSDSDGAESTSSSYSSLSDFVSDLYNSDIRGETPSFQREMQILAVDEAAVYSPPSQLHLPG 670 HSP 2 Score: 74.7146 bits (182), Expect = 2.323e-9 Identity = 36/152 (23.68%), Postives = 86/152 (56.58%), Query Frame = 2 Query: 2543 ISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHY 2998 + RK ++ERS L+ A + ++ + + + + + ENQ+ +++V +L+G + + + R+ ++E+E YRN ++SR+N+N+++ + ++ DVM+ S++ ++ + + +++G+ + N G S ++ LE+ THY Sbjct: 866 LGNRKALVERSGLVRHSSTAKTPQQKEPVK--VSESRTNANSENQQFLKEVISSVLEGKGMSWMKEGRVNKLMEDENYRNFVVSRLNRNMDEKVPEDAVHVEDVMV-SKNVLKGMLKLIKSIIHGLGHTINNHGLGGMASAYMVLEIAHTHY 1014
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Match: madd (MAP-kinase activating death domain [Source:ZFIN;Acc:ZDB-GENE-030131-8076]) HSP 1 Score: 469.544 bits (1207), Expect = 2.726e-138 Identity = 246/575 (42.78%), Postives = 355/575 (61.74%), Query Frame = 2 Query: 260 VPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSP-----------------IKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRI-RPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNG-----KDSIWPTLLGS-SVENT--NSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYREN 1894 P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++G RYGIC+NF+R +R P + ++ S + + GG+ ++S+ R R +LTSL ++SH+P F F+ CL ILK +++ R+ +R +D++W G+ SVE S + D+ EIE+W++RLL SPVPVAG+ R+++ +LP L + FALPD+ RF +VDFPLH EL+GV+ LK+ +LLE+KV+LQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FKMP DVW DLD +++ +N +++P + + L KH+KQAL S+S ++P+ N ++ EL L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR ++ F KLS TQAV+++ EW + P N F +I + YDP LIGDK KW+ L+P+ ++VY N Sbjct: 26 TPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFALTDKDSGITRYGICVNFYRSFQRDKPPQMDPAVEATEKSDPSTLSLSGDSTAPPAADGAVPPGEGGGGKSPRPKRSRAAARNRNSTLTSLCMLSHYPFFSTFRECLYILKRMVDCCSHRLNQRPGAAKGTQRDAMWRVFTGALSVEEKEKGSQLLQDLKEIESWVYRLLRSPVPVAGLRRVDVEVLPHELQPALTFALPDSSRFCMVDFPLHLPLELLGVDACLKVLSCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLDCNKVIAPSNAELLPPLPE---------PESSELKKHLKQALA------SMSLNTQPILNFEKFQEGQELPLLPPGRDKSSPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQATSFLASRPRRTGFADKLSHTQAVEYYGEWALNPTNLAFQRIHNNVYDPSLIGDKPKWYAHQLQPVFYRVYDGN 585 HSP 2 Score: 202.986 bits (515), Expect = 6.382e-52 Identity = 108/296 (36.49%), Postives = 171/296 (57.77%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVE 4600 R+YL + L GK +RS +WD + FWED F DAV ERE +G+DQ ++++DRY L ++++RLE +EDRLL +L+N IA+M+M +V I+ K R ++GKSHI L S IN+++D + L G ++ + + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E Sbjct: 1213 RIYLCEGLLGK-ERSTLWDQVQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGDHDRKRLEDDEDRLLATLLHNMIAYMLMTKVSKNDIRKKVRRLMGKSHIGLTYSQEINEVLDRLPQLTGRELPIRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELNHIKKCNTVK-GVFVLE 1506 HSP 3 Score: 62.3882 bits (150), Expect = 5.745e-9 Identity = 31/113 (27.43%), Postives = 62/113 (54.87%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L+G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV I + + ++ + + V+ +E SY G SVF LE+ THY K Sbjct: 909 ENQQFLKEVVQSVLEGQGVGWLNMKKVRRLLENEQLRIFVLSKLNRAVQSEEDARQEVIRDVEI-NRKVYKGMLDLLKCTVSSLEHSYTNAGLGGMASVFSLLEIARTHYQTK 1020
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Match: sbf1 (SET binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-040718-139]) HSP 1 Score: 85.5001 bits (210), Expect = 4.817e-16 Identity = 119/504 (23.61%), Postives = 194/504 (38.49%), Query Frame = 2 Query: 269 LLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPI------ERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEI--ETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRV-QSDFVKKLSKTQAVQFF 1753 +L+R+P D ++ PQ + FCQP G R A + FV LTD + R Y C FW + ER + T V +S+ + P+ SL++VS + F+ CL ++ +H D + + ET I LL+ +P+AG ++ ++L V P ND P+ + +F +G+ L LF A L E+K++ SK+Y L+ + AL A+++PL+Y F +LP + ++ + P+PFI G+ S F R + DV DLD +P+ + L LP P L++H + AL + LD L V Q PS ++ S D R + F + Y I++++P P++ F F+ R + + DF+ K+ A F Sbjct: 25 ILQRFPEKDWEDNPFPQGIELFCQPSGW-QLVPERLPA---SFFVAVLTDINSER-HYCACFTFWESVENPQVRERETDEDETLV----------------------LSQPEQLYAPK-----SLVLVSRLDHTEVFRNCLGLIY----------------------------------TVHVDSLNVPLETVIGNLLTCVIPIAGGSQRTITLGAGDRQ---VIQTPINDSLPVSGCSVAQLFRQLGIVNVLYLFCAALTEHKILFLSKSYQRLTDACRALLAIMFPLKYSFTYVPILPGKLL---EVLSTPTPFIIGVNSFF---RSETQELLDVIIADLD-------GGTVTIPEC-VHISL-LPEP-----LLQHTQTALSMV---------------LDPEL-EVADQAFPPSSTQPSALK---------IQDKEIRAVFLWLF--AQLFQGYRWCLHIIRIHPEPVIRFHKAAFLGQRALSEDDFLMKVLDGMAFAGF 412
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Match: dennd4b (DENN domain containing 4B [Source:NCBI gene;Acc:103038730]) HSP 1 Score: 80.4925 bits (197), Expect = 1.523e-14 Identity = 122/514 (23.74%), Postives = 198/514 (38.52%), Query Frame = 2 Query: 251 NSVVPE--LLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKD---FNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVA-----FQVDNFIKSR-RVQSDFVKKLSKTQAVQFFCE 1759 N++V E L+ RYP D ++ LP V FC P G N F+TFV T +G YG + F+ R + + RV L + R ++ ++ +++ S+ ++SH P F FQ KF + R S + P +E S H+V P P RI + L P ++ P + PL + + +G E A L +AVL E+K++L S +VL++ AL ++ +PL + P L P + + AP PFI G+ SS+ + + PSDV DLD + + + K + ++ P IL + K L I + L+ +L + + LI+G +++ + A +RF + +L Y F + P F + F+KSR R Q F +L++TQ F E Sbjct: 199 NALVYEAGLISRYPEEDLESFPLPDSVPVFCLPMGVTVESWPLNTKYQLPVFSTFVLT---SASGDKVYGAAIQFYEAYPREALSERQRVRLGLVSVVD----------RRPITNRTVQVK------KSVCVLSHWPFFTVFQ-----------KFLTFVYRYSISGPHVLP------IEKHISSFMHNV-------------PFPSPQRPRILVQLSP---YDNLLLCQPVSSPLPLSGASFVKLLQNLGAENACTLLLAVLTEHKLLLHSLRPDVLTSVSEALVSMTFPLRWPCPYIPLCPLRL---ADVLCAPMPFIVGVHSSYFDL---YDPPSDVVCVDLDTNTIFQSEDKKPLSWRSL-------PRKHGKILFSSLTSLHKT---LEKICTPGQEEATLEFLLTDYD----------------LIYGRQKQ-LELEIQEAFLRFMS--CLLRGYRSFLLPITQAPSDRTTDCSSLFNLQGFLKSRDRTQQKFYTQLTRTQMFTQFIE 625
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Match: dennd4b (DENN domain containing 4B [Source:NCBI gene;Acc:103038730]) HSP 1 Score: 80.1073 bits (196), Expect = 1.863e-14 Identity = 122/514 (23.74%), Postives = 198/514 (38.52%), Query Frame = 2 Query: 251 NSVVPE--LLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKD---FNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVA-----FQVDNFIKSR-RVQSDFVKKLSKTQAVQFFCE 1759 N++V E L+ RYP D ++ LP V FC P G N F+TFV T +G YG + F+ R + + RV L + R ++ ++ +++ S+ ++SH P F FQ KF + R S + P +E S H+V P P RI + L P ++ P + PL + + +G E A L +AVL E+K++L S +VL++ AL ++ +PL + P L P + + AP PFI G+ SS+ + + PSDV DLD + + + K + ++ P IL + K L I + L+ +L + + LI+G +++ + A +RF + +L Y F + P F + F+KSR R Q F +L++TQ F E Sbjct: 199 NALVYEAGLISRYPEEDLESFPLPDSVPVFCLPMGVTVESWPLNTKYQLPVFSTFVLT---SASGDKVYGAAIQFYEAYPREALSERQRVRLGLVSVVD----------RRPITNRTVQVK------KSVCVLSHWPFFTVFQ-----------KFLTFVYRYSISGPHVLP------IEKHISSFMHNV-------------PFPSPQRPRILVQLSP---YDNLLLCQPVSSPLPLSGASFVKLLQNLGAENACTLLLAVLTEHKLLLHSLRPDVLTSVSEALVSMTFPLRWPCPYIPLCPLRL---ADVLCAPMPFIVGVHSSYFDL---YDPPSDVVCVDLDTNTIFQSEDKKPLSWRSL-------PRKHGKILFSSLTSLHKT---LEKICTPGQEEATLEFLLTDYD----------------LIYGRQKQ-LELEIQEAFLRFMS--CLLRGYRSFLLPITQAPSDRTTDCSSLFNLQGFLKSRDRTQQKFYTQLTRTQMFTQFIE 625
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Match: sbf2 (SET binding factor 2 [Source:ZFIN;Acc:ZDB-GENE-030911-10]) HSP 1 Score: 78.5666 bits (192), Expect = 6.827e-14 Identity = 50/154 (32.47%), Postives = 82/154 (53.25%), Query Frame = 2 Query: 812 IETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLD 1273 +E + LL+ VPVAG ++ SL + P ND P+ + +F+ +G++ L LF AVL E+KV+ S +Y L + AL+AL++PL+Y +P +LP+ + ++ +P+PFI G+ S F ++ DV DLD Sbjct: 85 LEGLVASLLTCMVPVAGGSQKLFSLGAGDRQ---LIQTPLNDNLPVTTKSVALLFQQLGIQNVLSLFCAVLTEHKVLFHSTSYQRLEEACRALEALMFPLKYSYPYIPILPSRLL---EMLNSPTPFIMGVHSMF---QREIHELLDVIIADLD 229
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Match: sbf1 (SET binding factor 1 [Source:ZFIN;Acc:ZDB-GENE-040718-139]) HSP 1 Score: 96.6709 bits (239), Expect = 4.734e-20 Identity = 119/511 (23.29%), Postives = 207/511 (40.51%), Query Frame = 2 Query: 266 ELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEI--ETWIFRLLSSPVPVAGITRIELSLLP--ETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRR-VQSDFVKKLSKTQAVQFFCEWNIAPKNT 1783 ++++R+P + ++ PQ + FCQP G + N K FV LTD E+ R + CL F+ P + I ++ + G E S +R P+ SL++VS + ++ L ++ IH D +++ E + LL+ +P +G + SL +++P + N+ P+ + +F +G+ L LF AVL E+K++ S +Y L+ + AL AL +PL+Y + +LP S ++ + P+PFI G+ S+F R F+ DV DLD M+P+ + +LP P ++HI+ AL + V D + ++ P PS P + D R AM+R F +L Y ++++++ P++ F F+ R V++DF+ KL + A F P T Sbjct: 26 KIIQRFPDREWEDTPFPQGIELFCQPSGWKLS----NEWKQPTFFVAVLTDIESDR-HFCACLTFYEPEDSTYEIVTGHSFQQKDSES--------DGEGEDESHHMQRFAPK-----SLVLVSRLDYTEIYRQSLGLIY----------------------------------AIHVDDLKVTLENVVGNLLTCMIPTSGGAQKVFSLGAGDRQVIQPAL-----NNEIPVTGSSVILLFRQLGINNVLHLFCAVLTEHKILFHSSSYQRLTEACRALVALTFPLKYSYTYIPILPG---SLLEVLSTPTPFIIGVHSTF---RSEFQELLDVIIADLD-------GGTVMIPECVQVS--ALPEP-----YLQHIQTALSM-------------VLYPDLEVADMAFSPTSPSV-----IKP-------EMQDKEVRAAMLRLF--AQLLQGYRSCLQLIRIHSEPVIRFHKAAFLGQRGLVENDFIPKLLDSMAFAGFVSERGPPYRT 432
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010382.1 (pep scaffold:Pmarinus_7.0:GL482471:369374:413667:1 gene:ENSPMAG00000009395.1 transcript:ENSPMAT00000010382.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 87.4261 bits (215), Expect = 2.712e-17 Identity = 92/372 (24.73%), Postives = 149/372 (40.05%), Query Frame = 2 Query: 266 ELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEI--ETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILI 1375 ++L+R+P + ++ PQ + FCQP G T T R + FV LTD + R Y CL F P + E ++ + + ++ P+ SL++VS C + F+ CL +L H D + + ET + LLS VP AG + SL V P ND P+ + +F +G+ L LF A + E+KV+ S +Y LS + A+ AL++PL+Y +P +LP + ++ + P+PFI G+ S F+ +P V L L L N + P+ + L + D N+ + Sbjct: 8 KILQRFPAKEWEDAPFPQGLELFCQPSG-WKTSTERVPP---SFFVVVLTDINSER-HYCACLTFQEPFLEPNDSDGEEEEQEEVDDT-------------GLVKPAQVFAPK-----SLVLVSRRDCTEIFRNCLGLLY----------------------------------TAHTDSLRVPLETLVGNLLSCVVPTAGGAQKLFSLGAGDRQ---VIQAPLNDTLPITGSSVAILFRQLGIRHVLNLFCAAVTEHKVLFHSSSYQRLSDACRAMLALMFPLKYSYPYIPILPAQL---LEVLSTPTPFIIGVHSMFI-----NHLPDLVRHTALVLELSLATNGLSVQPRVANEMHLEIATMYDINVTV 311
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Match: dennd4a (DENN/MADD domain containing 4A [Source:ZFIN;Acc:ZDB-GENE-060503-285]) HSP 1 Score: 72.0182 bits (175), Expect = 1.209e-12 Identity = 125/532 (23.50%), Postives = 204/532 (38.35%), Query Frame = 2 Query: 269 LLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKD---FNTFVFTLTDKETGRVRYGICLNFWR--PIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDVMEIETWIFRLL-SSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVA-----FQVDNFIKSR-RVQSDFVKKLSKTQA-VQFFCEWNIAP-KNT--VFFQILSEKYD 1816 L+ RYP D+++ LP+ V FC P G C N F+TFV T + E YG + F+ P ER + + T++ G S H+ S+ ++SH P F+ F L L + SV +++ IE I + ++P P RI + L P + + P + PL + +G E L L A L+ENK+++ S + ++ AL ++++P + P L P + + + AP PFI G+ S + + + P D+ DLD + ++ K +LP K+ K+ QA E +N +E L Q S ++++G + + +++V + A +RF SIL Y + R + P F + F+KSR R F +L+KTQ ++F E + A KN FF EK D Sbjct: 213 LISRYPVGDYESFQLPESVPLFCLPLGATIECWQANTKYPMPIFSTFVLTGSSAEK---VYGAAIQFFEAYPGERLTDRQKTQL------------------GMLSAVDHKPIAGKVAHASKSICLLSHWPFFEAFHKFLLFLYRL-------------------------------SVSGPNLIPIEKHISHFMHNTPFPSPQRPRILVQLSPH---DSLTLSQPASSPLPLSGASFSMLLVNLGPEHLLALLHAALMENKILIHSLRPAIQTSVAEALVSVIFPFHWQCPYVPLCPLALAT---VLNAPFPFIVGVDSRYFEL---YDPPLDIVSVDLDTNTIFQNEEKKGTSWK------ALP------------KKPCKILQA-GLTRLYQELQRNYNETLQQ---QRKDDSLTDVAG----VRCRSAHTLEVEIQEAFLRFM--ASILKGYRSYLRPITQAPSEKATDASSLFDLQGFLKSRDRSYHKFYTQLTKTQMFIRFIEECSFAGDKNASLAFFDDCVEKVD 655
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Match: dennd5a (DENN/MADD domain containing 5A [Source:ZFIN;Acc:ZDB-GENE-071211-1]) HSP 1 Score: 71.2478 bits (173), Expect = 1.912e-12 Identity = 85/351 (24.22%), Postives = 143/351 (40.74%), Query Frame = 2 Query: 266 ELLRRYPHTDHKNGALPQDVV-YFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSNGKDSIWPTLLGSSVENTNSVIHHDV-------MEIETWIFRLLSS-PVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSD--VWFFDLDLRQL 1285 ++L YP+ N QD V C P G + +F++F+ T +E G YG L F+ + R PI+ E +++ + + G ES S T +SLL + H + + L K I I P + + +H V + +E++++ LL P+P G + + S M PVV P PL D+ L +FEL+G+E ++LF LLE++++L S++Y L + LL+P + +LP S AP P++ G+ + R ++P + + D+D R L Sbjct: 24 KVLAHYPNNVEWN-LFDQDAVGMLCMPRGLSFRTQADRRDPEFHSFLIT---REDGSRTYGFALTFFEEV-RSEPIR------EAMQTLYAMHRAEQAGLAESTSSDFGDTDSATGLSSSLLRMRHSASYDSSRDTLFTSKCIC---------------LIAPMPFVQACRKALTQLHTAVTSPQPPPLPLESYVYNLLYEVPLPPLGRS-LRFS---SVYMPPVVCQRPGPHELPLFDYCLREVFELLGLENVVQLFTCALLEHQILLLSRDYQRLMVVAEGIMVLLFPFSWQHVYVPILPA---SLLHFLDAPVPYLMGLQIDGEMGRNGLELPQEASLCLVDVDNRSL 341
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Match: dennd4a (DENN/MADD domain containing 4A [Source:ZFIN;Acc:ZDB-GENE-060503-285]) HSP 1 Score: 62.3882 bits (150), Expect = 1.043e-9 Identity = 76/319 (23.82%), Postives = 127/319 (39.81%), Query Frame = 2 Query: 845 PVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEI------SGFNPLIFGNDS--DSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVA-----FQVDNFIKSR-RVQSDFVKKLSKTQAVQFFCE 1759 P P + RI L+ T +V + P P+ T+ + +G E A L + L ENK+++ S VL+++ AL A+++P + P L P S + +AP PFI G+ S + + ++ P DV DLD + + K + ++ +L K +P KNL L N+ Q + + + SG L F + +++ + A +RF SIL Y + R + P F + F+KSR R + F ++ +TQ F E Sbjct: 358 PFPSSQRPRI---LVQATANDSLVLSQPIASPLPIRGASFCTLLQNLGPENAATLLLFALTENKILIHSLRPAVLTSAAEALNAMIFPFHWQCPYIPLCPL---SLADMLSAPCPFIVGVDSRYFDL---YEPPPDVVSVDLDTNTISQTEERKSL---------------NWRLLPK-------------------KPCKNLMNTLTNLHQQIVAMNHRSMEDPVLESGIFDLDFKRRARQQQLEMEIQEAFLRFM--ASILKGYRTYLRPITQAPSEKATDARSLFDLQGFLKSRDRAYNKFYSQMMRTQMFIRFIE 631
BLAST of MAP kinase-activating death domain protein vs. Ensembl Nematostella
Match: EDO49267 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RH02]) HSP 1 Score: 412.149 bits (1058), Expect = 1.860e-119 Identity = 233/590 (39.49%), Postives = 349/590 (59.15%), Query Frame = 2 Query: 191 RLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERRSPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKRIRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIK-RRSNGKDSIWPTLLGSSVENTN-----SVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVR-KSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKP--SQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDF 1933 RL+DY+ +VG+R P ++ P LLRR+P DH + LP DVV+FCQP+ C +T + + + ++ N+F+FTLTDK+T +VRYG+C+N +RP + + + G+ SR SK R +LTS+ IVSHH F F+ CL +L+++I D R+ R + D+ P L SV + S I + EIETWI RLL +P PV G T++++ LL + FA P+N RFPL+DFP+H EL+GVE LK+ +LLE KV++QS++YN L+ S++AL LLYPLEYMFPI LLPT M +AEQL AP+P++ G+P+SF + K F++P D+W FDLD ++ +P + ++L P + +LI+ +K AL+ ++S + V NL+ N L P + + S ++FGND DSVDV+ RVA+V FF S ++L + TR L+L+PRP+VA Q F+KSR SDFV L+++Q+V++F EW ++P NT + +I Y+P +IGDK KW+ + LE + ++VY + L + D+ Sbjct: 12 RLVDYVILVGVRTPTLD---STETPRLLRRFPEKDHDDFPLPPDVVFFCQPEAC-NTVSKKFSLREANSFIFTLTDKDTNKVRYGVCMNIYRPCSQ---------------FHFRDDQDGIKDGKRKRSR-SKNKREICMTLTSICIVSHHSFFATFRECLFVLRKMI---DSRVGGERYDKNDNFIPGLHSWSVFTCSEDPKLSPIATQMDEIETWIQRLLLAPAPVIGRTKVDMELLCPESYPSLTFAYPENTRFPLIDFPVHIPMELLGVETCLKVLTCILLEQKVVIQSRDYNALTMSVIALTRLLYPLEYMFPIIPLLPTCMANAEQLLLAPTPYVIGVPASFFRYKSKDFQIPGDLWVFDLDSSKV-------KIPMSA--DELPDLPEEEGQVLIRRLKMALQ------ALSMPPQTVGNLE----NAAPDGLLPDNTSGDASIEEHMVFGNDVDSVDVAVRVAIVNFFMSPTVLCGLQEHTRTLRLFPRPVVALQKGPFLKSRPKPSDFVAALAESQSVEYFAEWLVSPTNTAYLKINKGIYNPCVIGDKPKWYSEHLETVLYQVYDKESKLCLEPWIDVDY 559 HSP 2 Score: 136.732 bits (343), Expect = 4.373e-32 Identity = 92/327 (28.13%), Postives = 162/327 (49.54%), Query Frame = 2 Query: 3719 DSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELI----QAIQKHSEKFRSVIEPDT-----SQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 D R YLF+ L +RS +WDNM FWE++F DAV ER+ +G+DQ ++++RY L E++RLE ED+LL L N +AFM+ + V ++ +G+S + ++ ++ I + R D +T+ V V C + + V++ DC+LLR+ +G I RWW E+ + T K V+C+ R + ++S+ KK K L + +Q+ +E+ R P+T +F V D + G L++ G+ +D ++R C T+K F+++ + +Y++ +++ N I Sbjct: 1100 DRSTTGRRYLFEGLV--RERSPLWDNMDFWENIFLDAVAAERDAVGMDQGPTEMLERYKSLQPVEQKRLEEEEDKLLATTLYNTVAFMLHWMCN-VIVRRTVFGNVGRSWKGYAVAPRMDAVLLFI-FFRALDDSDVTSARHAVVVGFGHVMCLMILFNRMTVSD---DCILLRTGAGVIIERWWYEKMVNITYCPKTKVLCLWYRRGEDTLLSKFCTKKCKALYFCIKECMQRAAERLRG---PNTGPQLGGEFLVEDISSGEEGKLQVTLEGIGLKFATRRVHIDLCHIRNCSTQK-GEFVLDEFGKCKTSFSYQLI-AFTCNQI 1414
BLAST of MAP kinase-activating death domain protein vs. Ensembl Nematostella
Match: EDO30806 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZQ4]) HSP 1 Score: 55.0694 bits (131), Expect = 1.527e-7 Identity = 39/156 (25.00%), Postives = 78/156 (50.00%), Query Frame = 2 Query: 812 IETWIFRLLSS-PVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDL 1276 +E++I+ LL P+P G T + + + E+ + P + PL D+ L +F +GVE ++LF VLLE++++L S +++ + L++P + +LP + + AP PFI G+ + + + ++PS+ +D+ Sbjct: 223 LESYIYNLLYEVPLPPPGRT-MRFNCVKES----ITCQRPGPNELPLFDYSLKEMFSWLGVENVVELFTCVLLEHQILLLSNSFHRFMLVAEGVVTLIFPFIWQHVYVPILPAAL---QHFLDAPVPFIMGLYCASEDFKANLQLPSEASLCLVDI 370
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Match: madd (MAP kinase activating death domain [Source:NCBI gene;Acc:101163236]) HSP 1 Score: 497.664 bits (1280), Expect = 4.009e-148 Identity = 269/611 (44.03%), Postives = 384/611 (62.85%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIER-------------RSPIKVTRVXXXXXXXXXXXXXXXFQG--GRESM--SRQSKR------IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSN-----GKDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++ RYGIC+NF+R +R +P K + E + +S A ++ ES+ S Q +R R R +LTSL I+SH+P F F+ CL+ILK +++ +R+ +R+ +D++W G+ SVE S + D+ +IE+W++RLL SPVPVA R+++ +LP L + + FALPDN RF LVDFPLH EL+GV+ L++ VLLE+KVILQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FK+P DVW DLD + K++ TN ++ LP P + + L KH+KQAL S+S ++P+ NL++ +L L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR +S F +KLS TQAV+F+ EW ++P N F +I + +DP LIGDK KW+ L+ + ++VY + GS Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SSDSVAQTPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFMLTDKDSSTTRYGICVNFYRSFQRGHHRPRGDKSGHTETPSKAAETTGEVSDGSSGASSTVLPAPTSTESVPPSPQHRRNAAKVAARNRNSTLTSLCILSHYPFFSTFRECLNILKRLVDCCSQRLTQRAGLPRATQRDTMWRVFTGALSVEEKGSQLLADLRDIESWVYRLLRSPVPVASQRRVDVEVLPHELKRALTFALPDNSRFTLVDFPLHLPLELLGVDACLQVLSCVLLEHKVILQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKIPDDVWLVDLD--------SSKVIAPTNAESLPPLPEP-EASELKKHLKQALA------SMSLNTQPILNLEKFQEGQDLSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRSPFAEKLSHTQAVEFYGEWALSPTNLAFQRIHNNVFDPSLIGDKPKWYAHQLQSVVYRVY-DGGS 593 HSP 2 Score: 211.46 bits (537), Expect = 1.709e-54 Identity = 112/318 (35.22%), Postives = 182/318 (57.23%), Query Frame = 2 Query: 3737 RMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 R+YL + L GK +RS +WD M FWED + DAV ERE +G+DQ +++++RY L ++++RLE +EDRLL +L+N IA+M+M++V+ I+ K R ++GKSHI L S IN+++D + + G ++ + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E P TK + +K+ A+ I Sbjct: 1183 RIYLCEGLLGK-ERSTLWDQMQFWEDAYLDAVMLEREGMGMDQGPQEMIERYLSLGEHDRKRLEDDEDRLLATLLHNMIAYMLMLKVNKNDIRKKVRRLMGKSHIGLTYSQEINEILDKLANMNGRELSTRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELSHIKKCNTVK-GVFVLEEFVPETKEVVIHKYKTPMAHQI 1498 HSP 3 Score: 63.5438 bits (153), Expect = 2.094e-9 Identity = 32/113 (28.32%), Postives = 61/113 (53.98%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV + S + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 856 ENQQFLKEVVQSVLDGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDARQEIIRDVEV-SRKVYKGMLDILKCTVSSLEQSYTNAGLGGMASVFSLLEIARTHYQTK 967
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Match: madd (MAP kinase activating death domain [Source:NCBI gene;Acc:101163236]) HSP 1 Score: 494.582 bits (1272), Expect = 1.168e-146 Identity = 265/629 (42.13%), Postives = 375/629 (59.62%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR--------------------------------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKR---IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSN-----GKDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++ RYGIC+NF+R +R +P V S GR R++ R R +LTSL I+SH+P F F+ CL+ILK +++ +R+ +R+ +D++W G+ SVE S + D+ +IE+W++RLL SPVPVA R+++ +LP L + + FALPDN RF LVDFPLH EL+GV+ L++ VLLE+KVILQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FK+P DVW DLD + K++ TN ++ LP P + + L KH+KQAL S+S ++P+ NL++ +L L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR +S F +KLS TQAV+F+ EW ++P N F +I + +DP LIGDK KW+ L+ + ++VY + GS Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SSDSVAQTPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFMLTDKDSSTTRYGICVNFYRSFQRGHHRPRGDKSGHTETPSKAAETTGEVSDGSSGASSTVLPAPTSTESVPPPASAEQSEQAGDELNSGRSPQHRRNAAKVAARNRNSTLTSLCILSHYPFFSTFRECLNILKRLVDCCSQRLTQRAGLPRATQRDTMWRVFTGALSVEEKGSQLLADLRDIESWVYRLLRSPVPVASQRRVDVEVLPHELKRALTFALPDNSRFTLVDFPLHLPLELLGVDACLQVLSCVLLEHKVILQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKIPDDVWLVDLD--------SSKVIAPTNAESLPPLPEP-EASELKKHLKQALA------SMSLNTQPILNLEKFQEGQDLSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRSPFAEKLSHTQAVEFYGEWALSPTNLAFQRIHNNVFDPSLIGDKPKWYAHQLQSVVYRVY-DGGS 611 HSP 2 Score: 186.808 bits (473), Expect = 6.256e-47 Identity = 94/256 (36.72%), Postives = 148/256 (57.81%), Query Frame = 2 Query: 3773 DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTF 4516 +RS +WD M FWED + DAV ERE +G+DQ +++++RY L ++++RLE +EDRLL +L+N IA+M+M++V+ I+ K R ++GKSHI L S IN+++D + + G ++ + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ Sbjct: 1298 ERSTLWDQMQFWEDAYLDAVMLEREGMGMDQGPQEMIERYLSLGEHDRKRLEDDEDRLLATLLHNMIAYMLMLKVNKNDIRKKVRRLMGKSHIGLTYSQEINEILDKLANMNGRELSTRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINL 1553 HSP 3 Score: 63.929 bits (154), Expect = 1.908e-9 Identity = 32/113 (28.32%), Postives = 61/113 (53.98%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV + S + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 939 ENQQFLKEVVQSVLDGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDARQEIIRDVEV-SRKVYKGMLDILKCTVSSLEQSYTNAGLGGMASVFSLLEIARTHYQTK 1050
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Match: madd (MAP kinase activating death domain [Source:NCBI gene;Acc:101163236]) HSP 1 Score: 494.582 bits (1272), Expect = 1.399e-146 Identity = 265/629 (42.13%), Postives = 375/629 (59.62%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR--------------------------------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKR---IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSN-----GKDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++ RYGIC+NF+R +R +P V S GR R++ R R +LTSL I+SH+P F F+ CL+ILK +++ +R+ +R+ +D++W G+ SVE S + D+ +IE+W++RLL SPVPVA R+++ +LP L + + FALPDN RF LVDFPLH EL+GV+ L++ VLLE+KVILQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FK+P DVW DLD + K++ TN ++ LP P + + L KH+KQAL S+S ++P+ NL++ +L L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR +S F +KLS TQAV+F+ EW ++P N F +I + +DP LIGDK KW+ L+ + ++VY + GS Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SSDSVAQTPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFMLTDKDSSTTRYGICVNFYRSFQRGHHRPRGDKSGHTETPSKAAETTGEVSDGSSGASSTVLPAPTSTESVPPPASAEQSEQAGDELNSGRSPQHRRNAAKVAARNRNSTLTSLCILSHYPFFSTFRECLNILKRLVDCCSQRLTQRAGLPRATQRDTMWRVFTGALSVEEKGSQLLADLRDIESWVYRLLRSPVPVASQRRVDVEVLPHELKRALTFALPDNSRFTLVDFPLHLPLELLGVDACLQVLSCVLLEHKVILQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKIPDDVWLVDLD--------SSKVIAPTNAESLPPLPEP-EASELKKHLKQALA------SMSLNTQPILNLEKFQEGQDLSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRSPFAEKLSHTQAVEFYGEWALSPTNLAFQRIHNNVFDPSLIGDKPKWYAHQLQSVVYRVY-DGGS 611 HSP 2 Score: 196.438 bits (498), Expect = 7.517e-50 Identity = 103/295 (34.92%), Postives = 169/295 (57.29%), Query Frame = 2 Query: 3773 DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVE----ILDPNTK 4621 +RS +WD M FWED + DAV ERE +G+DQ +++++RY L ++++RLE +EDRLL +L+N IA+M+M++V+ I+ K R ++GKSHI L S IN+++D + + G ++ + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E ILD + + Sbjct: 1298 ERSTLWDQMQFWEDAYLDAVMLEREGMGMDQGPQEMIERYLSLGEHDRKRLEDDEDRLLATLLHNMIAYMLMLKVNKNDIRKKVRRLMGKSHIGLTYSQEINEILDKLANMNGRELSTRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELSHIKKCNTVK-GVFVLEEFAFILDADAE 1591 HSP 3 Score: 63.5438 bits (153), Expect = 2.165e-9 Identity = 32/113 (28.32%), Postives = 61/113 (53.98%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV + S + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 939 ENQQFLKEVVQSVLDGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDARQEIIRDVEV-SRKVYKGMLDILKCTVSSLEQSYTNAGLGGMASVFSLLEIARTHYQTK 1050
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Match: madd (MAP kinase activating death domain [Source:NCBI gene;Acc:101163236]) HSP 1 Score: 494.967 bits (1273), Expect = 1.820e-146 Identity = 265/629 (42.13%), Postives = 375/629 (59.62%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR--------------------------------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKR---IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSN-----GKDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++ RYGIC+NF+R +R +P V S GR R++ R R +LTSL I+SH+P F F+ CL+ILK +++ +R+ +R+ +D++W G+ SVE S + D+ +IE+W++RLL SPVPVA R+++ +LP L + + FALPDN RF LVDFPLH EL+GV+ L++ VLLE+KVILQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FK+P DVW DLD + K++ TN ++ LP P + + L KH+KQAL S+S ++P+ NL++ +L L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR +S F +KLS TQAV+F+ EW ++P N F +I + +DP LIGDK KW+ L+ + ++VY + GS Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SSDSVAQTPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFMLTDKDSSTTRYGICVNFYRSFQRGHHRPRGDKSGHTETPSKAAETTGEVSDGSSGASSTVLPAPTSTESVPPPASAEQSEQAGDELNSGRSPQHRRNAAKVAARNRNSTLTSLCILSHYPFFSTFRECLNILKRLVDCCSQRLTQRAGLPRATQRDTMWRVFTGALSVEEKGSQLLADLRDIESWVYRLLRSPVPVASQRRVDVEVLPHELKRALTFALPDNSRFTLVDFPLHLPLELLGVDACLQVLSCVLLEHKVILQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKIPDDVWLVDLD--------SSKVIAPTNAESLPPLPEP-EASELKKHLKQALA------SMSLNTQPILNLEKFQEGQDLSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRSPFAEKLSHTQAVEFYGEWALSPTNLAFQRIHNNVFDPSLIGDKPKWYAHQLQSVVYRVY-DGGS 611 HSP 2 Score: 204.142 bits (518), Expect = 3.185e-52 Identity = 106/306 (34.64%), Postives = 174/306 (56.86%), Query Frame = 2 Query: 3773 DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +RS +WD M FWED + DAV ERE +G+DQ +++++RY L ++++RLE +EDRLL +L+N IA+M+M++V+ I+ K R ++GKSHI L S IN+++D + + G ++ + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ ++ F++ ++++C T K F++E P TK + +K+ A+ I Sbjct: 1298 ERSTLWDQMQFWEDAYLDAVMLEREGMGMDQGPQEMIERYLSLGEHDRKRLEDDEDRLLATLLHNMIAYMLMLKVNKNDIRKKVRRLMGKSHIGLTYSQEINEILDKLANMNGRELSTRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIELSHIKKCNTVK-GVFVLEEFVPETKEVVIHKYKTPMAHQI 1602 HSP 3 Score: 63.929 bits (154), Expect = 1.983e-9 Identity = 32/113 (28.32%), Postives = 61/113 (53.98%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV + S + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 939 ENQQFLKEVVQSVLDGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDARQEIIRDVEV-SRKVYKGMLDILKCTVSSLEQSYTNAGLGGMASVFSLLEIARTHYQTK 1050
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Match: madd (MAP kinase activating death domain [Source:NCBI gene;Acc:101163236]) HSP 1 Score: 495.352 bits (1274), Expect = 1.968e-146 Identity = 265/629 (42.13%), Postives = 375/629 (59.62%), Query Frame = 2 Query: 167 MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPQDVVYFCQPDGCISTCTSRNAAKDFNTFVFTLTDKETGRVRYGICLNFWRPIERR--------------------------------------SPIKVTRVXXXXXXXXXXXXXXXFQGGRESMSRQSKR---IRPRTHSLTSLLIVSHHPCFKGFQTCLSILKEIIEKFDERIKRRSN-----GKDSIWPTLLGS-SVENTNSVIHHDVMEIETWIFRLLSSPVPVAGITRIELSLLPETLMKPVVFALPDNDRFPLVDFPLHTIFELMGVEFALKLFIAVLLENKVILQSKNYNVLSTSILALKALLYPLEYMFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISG----FNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGS 1900 M + +CPRL+DYL +VG R P S + P+LLRRYP DH + LP DVV+FCQP+GC+S R + +D ++FVF LTDK++ RYGIC+NF+R +R +P V S GR R++ R R +LTSL I+SH+P F F+ CL+ILK +++ +R+ +R+ +D++W G+ SVE S + D+ +IE+W++RLL SPVPVA R+++ +LP L + + FALPDN RF LVDFPLH EL+GV+ L++ VLLE+KVILQS++YN LS S++A A++YPLEYMFP+ LLPT M SAEQL AP+P+I G+P+SF L + FK+P DVW DLD + K++ TN ++ LP P + + L KH+KQAL S+S ++P+ NL++ +L L P + + S FNPLI+GND DSVDV+TRVAMVRFFNS ++L + TR L+L+PRP+VAFQ +F+ SR +S F +KLS TQAV+F+ EW ++P N F +I + +DP LIGDK KW+ L+ + ++VY + GS Sbjct: 1 MEKKKMCPRLLDYLVVVGARQP--SSDSVAQTPQLLRRYPLEDHPDFPLPPDVVFFCQPEGCLSIRQRRVSLRDDSSFVFMLTDKDSSTTRYGICVNFYRSFQRGHHRPRGDKSGHTETPSKAAETTGEVSDGSSGASSTVLPAPTSTESVPPPASAEQSEQAGDELNSGRSPQHRRNAAKVAARNRNSTLTSLCILSHYPFFSTFRECLNILKRLVDCCSQRLTQRAGLPRATQRDTMWRVFTGALSVEEKGSQLLADLRDIESWVYRLLRSPVPVASQRRVDVEVLPHELKRALTFALPDNSRFTLVDFPLHLPLELLGVDACLQVLSCVLLEHKVILQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKIPDDVWLVDLD--------SSKVIAPTNAESLPPLPEP-EASELKKHLKQALA------SMSLNTQPILNLEKFQEGQDLSLLPPGRDKASPSSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNVLQGFQMHTRTLRLFPRPVVAFQSTSFLASRPRRSPFAEKLSHTQAVEFYGEWALSPTNLAFQRIHNNVFDPSLIGDKPKWYAHQLQSVVYRVY-DGGS 611 HSP 2 Score: 200.675 bits (509), Expect = 3.579e-51 Identity = 107/309 (34.63%), Postives = 173/309 (55.99%), Query Frame = 2 Query: 3773 DRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCT--SKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKF---RSVIEPD---TSQFKVTDDVTKCSGSLKIDKNGLTFT---SDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 +RS +WD M FWED + DAV ERE +G+DQ +++++RY L ++++RLE +EDRLL +L+N IA+M+M++V+ I+ K R ++GKSHI L S IN+++D + + G ++ + SR Q F V+ G D GDI E+ DC++LRS G + RWW E+ I T K V+C+ RR E +++ Y KK +EL ++ E+ + I+P +F V D T G L++ G+ S F++ ++++C T K F++E P TK + +K+ A+ I Sbjct: 1315 ERSTLWDQMQFWEDAYLDAVMLEREGMGMDQGPQEMIERYLSLGEHDRKRLEDDEDRLLATLLHNMIAYMLMLKVNKNDIRKKVRRLMGKSHIGLTYSQEINEILDKLANMNGRELSTRPSGSRHIKKQTFVVHAGTDTTGDIFFMEVCDDCIVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQERKVFIELSHIKKCNTVK-GVFVLEEFVPETKEVVIHKYKTPMAHQI 1622 HSP 3 Score: 63.929 bits (154), Expect = 1.890e-9 Identity = 32/113 (28.32%), Postives = 61/113 (53.98%), Query Frame = 2 Query: 2669 ENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEK 3007 ENQ+ +++V +L G ++ +++ ++ENE R +LS++N+ ++ + ++ I DV + S + ++ I + V+ +E SY G SVF LE+ THY K Sbjct: 939 ENQQFLKEVVQSVLDGQGVGWLNMKKVRRLLENEQLRVFVLSKLNRAVQSEEDARQEIIRDVEV-SRKVYKGMLDILKCTVSSLEQSYTNAGLGGMASVFSLLEIARTHYQTK 1050
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Match: SMESG000048179.1 (SMESG000048179.1) HSP 1 Score: 2159.41 bits (5594), Expect = 0.000e+0 Identity = 1133/1139 (99.47%), Postives = 1133/1139 (99.47%), Query Frame = 2 Query: 1118 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKXXXXXXXXXXXXXXXXXQEILKSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKXXXXXXXXXXXXPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 4534 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD Sbjct: 1 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL------NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 1133
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Match: SMESG000048179.1 (SMESG000048179.1) HSP 1 Score: 2158.26 bits (5591), Expect = 0.000e+0 Identity = 1142/1183 (96.53%), Postives = 1143/1183 (96.62%), Query Frame = 2 Query: 1118 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKXXXXXXXXXXXXXXXXXQEILKSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKXXXXXXXXXXXXPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSANLI 4666 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYS + I Sbjct: 1 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL------NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI--------------------------------GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTDWFVDFVNVRRCFTKKPDRFIVEILDPNTKNLTYRIFKSYSYDQI 1145
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Match: SMESG000048179.1 (SMESG000048179.1) HSP 1 Score: 2075.44 bits (5376), Expect = 0.000e+0 Identity = 1101/1139 (96.66%), Postives = 1101/1139 (96.66%), Query Frame = 2 Query: 1118 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKXXXXXXXXXXXXXXXXXQEILKSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKXXXXXXXXXXXXPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 4534 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD Sbjct: 1 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL------NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI--------------------------------GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 1101
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Match: SMESG000048179.1 (SMESG000048179.1) HSP 1 Score: 2075.06 bits (5375), Expect = 0.000e+0 Identity = 1101/1139 (96.66%), Postives = 1101/1139 (96.66%), Query Frame = 2 Query: 1118 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKXXXXXXXXXXXXXXXXXQEILKSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKXXXXXXXXXXXXPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 4534 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD Sbjct: 1 MFPISTLLPTHMPSAEQLFTAPSPFIFGIPSSFLLVRKSFKMPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL------NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASI--------------------------------GVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 1101 HSP 2 Score: 90.1225 bits (222), Expect = 1.212e-17 Identity = 39/40 (97.50%), Postives = 40/40 (100.00%), Query Frame = 1 Query: 4534 LVCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF 4653 +VCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF Sbjct: 1110 VVCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF 1149 HSP 3 Score: 78.9518 bits (193), Expect = 3.292e-14 Identity = 38/38 (100.00%), Postives = 38/38 (100.00%), Query Frame = 2 Query: 4862 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL 4975 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL Sbjct: 1153 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL 1190
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Match: SMESG000048179.1 (SMESG000048179.1) HSP 1 Score: 2074.67 bits (5374), Expect = 0.000e+0 Identity = 1092/1098 (99.45%), Postives = 1092/1098 (99.45%), Query Frame = 2 Query: 1241 MPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQALKVCQALNSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTXXXXXXXXXXXXXXXXNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKXXXXXXXXXXXXXXXXXQEILKSNPTYKPISERKPVIERSELINKLKEAHXXXXXXXXXXFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGXXXXXXXXXXXXXPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKXXXXXXXXXXXXPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 4534 MPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD Sbjct: 1 MPSDVWFFDLDLRQLLKHNNHKMVPQTNIDNDLSLPPPADFNILIKHIKQAL------NSISDKSEPVKNLDEVLNNVELQPLKPSQSEISGFNPLIFGNDSDSVDVSTRVAMVRFFNSQSILGNYTKFTRILKLYPRPIVAFQVDNFIKSRRVQSDFVKKLSKTQAVQFFCEWNIAPKNTVFFQILSEKYDPRLIGDKSKWFDQSLEPINFKVYRENGSCTLHLLFNQDFNTESDCPTDESGSDSDHISDSSSSNRELTETCSDLADSGISECQRLTVDPTKIYYPPTYLQIPSINIIESEKDSIFKIKMESNTRKFVASDTEEMNIKKREREVKRQHNLSNKRKSVDKNQSKDPKTFTTGNAYDTDNETNTSCTSEPLKQTSLSGSAVSSNSYSEFWNETSKKLSGFFGSPLSPSKPSLSQEILKSNPTYKPISERKPVIERSELINKLKEAHSDSRRSSTSSFLFKDKKSIDYENQETIQQVTDEILKGSTPNIISKYRIKNIVENEAYRNLILSRINKNLEKNINCKETYINDVMIESEDHFNALVWISRILVNGIECSYNKGICDGFGSVFVFLEMLFTHYVEKKGMNSSISVSSMNFSPVTNDEKPPYFDGLPNGNMVASIADLWKYTTQYTANWDLIKVSISESWKDIQEYAGVPLNINGELYETIEISSKNDINATHGVSMSNSDIDETHSLFSPRAPPSPGSSVFKRGSVNVPRTLNIRSDTSSLVSFKDDDISAIIDYSIPYKSTVTFGYRFKLNQLYFMKEPKLPTEISPSNREKSSPRDGSFFSRIINSPQKTFQSNSAPVSGNNIDNNGVVEGDSMANQRMYLFQKLTGKNDRSKIWDNMAFWEDVFYDAVCQEREIIGLDQDSKDLMDRYNGLDMNEKQRLERNEDRLLGIVLNNFIAFMIMMRVDPVKIKSKARCMIGKSHIALDESANINKLIDSIKYLRGNDVDLLTNMSRQQDVQLFPVYCGVDKKGDICVAEIHSDCMLLRSISGAINARWWLERFIKCTSKKNVICITRRENNEVVMSQLYCKKSKELIQAIQKHSEKFRSVIEPDTSQFKVTDDVTKCSGSLKIDKNGLTFTSDNTD 1092 HSP 2 Score: 90.5077 bits (223), Expect = 1.064e-17 Identity = 39/40 (97.50%), Postives = 40/40 (100.00%), Query Frame = 1 Query: 4534 LVCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF 4653 +VCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF Sbjct: 1101 VVCRFCQCQEMFHQKARPIYCRNLRPKHEESHLQNFQIVF 1140 HSP 3 Score: 78.9518 bits (193), Expect = 3.146e-14 Identity = 38/38 (100.00%), Postives = 38/38 (100.00%), Query Frame = 2 Query: 4862 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL 4975 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL Sbjct: 1144 NCLLCSDKVLIAVDRSNKPFQQSFIATIKTSVLNKIRL 1181 The following BLAST results are available for this feature:
BLAST of MAP kinase-activating death domain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of MAP kinase-activating death domain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of MAP kinase-activating death domain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of MAP kinase-activating death domain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of MAP kinase-activating death domain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020839 ID=SMED30020839|Name=MAP kinase-activating death domain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=5320bpback to top protein sequence of SMED30020839-orf-1 >SMED30020839-orf-1 ID=SMED30020839-orf-1|Name=SMED30020839-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1562bp MANESICPRLIDYLSIVGLRNPNRSGHKNSVVPELLRRYPHTDHKNGALPback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|