SMED30020818

Overview
NameSMED30020818
Smed IDSMED30020818
Length (bp)3226
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SMED30020818 (SMED30020818) t-SNE clustered cells

Violin plots show distribution of expression levels for SMED30020818 (SMED30020818) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SMED30020818 (SMED30020818) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SMED30020818 (SMED30020818) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020818

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
cephalic gangliaSMED30020818 dd_Smed_v4_4628_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30020818 dd_Smed_v4_4628_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30020818 dd_Smed_v4_4628_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of SMED30020818 vs. Planmine SMEST
Match: SMESG000017552.1 (SMESG000017552.1)

HSP 1 Score: 351.288 bits (900), Expect = 1.229e-109
Identity = 173/185 (93.51%), Postives = 177/185 (95.68%), Query Frame = 3 
Query:  198 MKKFYTLTFNSTGQKAGSDKLFNIKPQLSYFLENTNVNHFTNIRTDAPARHLPGSIDDYGNKIFENSLSELRLLTIENNADPYLIELYYMIYVFLNGSMEIPIDDAVRFWNKIKITDILGFYPSEQIDQLLTKPFELEGLQSKILYALNIFRNLIAEVVTFDILLNYKYLHFFCNKLYFNITKNF 752
            MKKF TLT +STGQKAGSDKLFNIKPQLSYFLENTNVNHF NIRTDAP R LPGSIDDYGNKIFEN LSELRLLTIENNADPYLIELYY IYVFLNGSMEIPIDDAVRFWNKIKITDILG YPSEQIDQLLTKPFELEGLQSKILYALNIFR+LIA+VVTFDILLNYKYL+FFCNKLYFNITKNF
Sbjct:    1 MKKFNTLTLDSTGQKAGSDKLFNIKPQLSYFLENTNVNHFMNIRTDAPVRPLPGSIDDYGNKIFENRLSELRLLTIENNADPYLIELYYKIYVFLNGSMEIPIDDAVRFWNKIKITDILGSYPSEQIDQLLTKPFELEGLQSKILYALNIFRDLIADVVTFDILLNYKYLNFFCNKLYFNITKNF 185
[Close]
BLAST of SMED30020818 vs. Planmine SMEST
Match: SMESG000012629.1 (SMESG000012629.1)

HSP 1 Score: 312.383 bits (799), Expect = 1.781e-99
Identity = 158/185 (85.41%), Postives = 167/185 (90.27%), Query Frame = 3 
Query:  198 MKKFYTLTFNSTGQKAGSDKLFNIKPQLSYFLENTNVNHFTNIRTDAPARHLPGSIDDYGNKIFENSLSELRLLTIENNADPYLIELYYMIYVFLNGSMEIPIDDAVRFWNKIKITDILGFYPSEQIDQLLTKPFELEGLQSKILYALNIFRNLIAEVVTFDILLNYKYLHFFCNKLYFNITKNF 752
            MKKF     NST QKAGSDKLFN K QLSY LENTNVN+F NIRTDAP   LPGSID+YGNKIFENSLSELRL+TIENNADPYLIEL Y IYVFLNGSMEIPIDDAV+FWNKIK+TDILG Y S+QIDQLLTKP ELEGLQSKILYALNIFR+LIA+VVTFDILLNYKYL+FFCNKLYFNITKNF
Sbjct:    1 MKKFDN--SNSTEQKAGSDKLFNTKSQLSYILENTNVNNFMNIRTDAPVGPLPGSIDNYGNKIFENSLSELRLITIENNADPYLIELCYKIYVFLNGSMEIPIDDAVKFWNKIKLTDILGSYASQQIDQLLTKPLELEGLQSKILYALNIFRDLIADVVTFDILLNYKYLNFFCNKLYFNITKNF 183
[Close]
BLAST of SMED30020818 vs. Planmine SMEST
Match: SMESG000017552.1 (SMESG000017552.1)

HSP 1 Score: 278.1 bits (710), Expect = 5.903e-83
Identity = 136/144 (94.44%), Postives = 139/144 (96.53%), Query Frame = 3 
Query:  321 NIRTDAPARHLPGSIDDYGNKIFENSLSELRLLTIENNADPYLIELYYMIYVFLNGSMEIPIDDAVRFWNKIKITDILGFYPSEQIDQLLTKPFELEGLQSKILYALNIFRNLIAEVVTFDILLNYKYLHFFCNKLYFNITKNF 752
            NIRTDAP R LPGSIDDYGNKIFEN LSELRLLTIENNADPYLIELYY IYVFLNGSMEIPIDDAVRFWNKIKITDILG YPSEQIDQLLTKPFELEGLQSKILYALNIFR+LIA+VVTFDILLNYKYL+FFCNKLYFNITKNF
Sbjct:    2 NIRTDAPVRPLPGSIDDYGNKIFENRLSELRLLTIENNADPYLIELYYKIYVFLNGSMEIPIDDAVRFWNKIKITDILGSYPSEQIDQLLTKPFELEGLQSKILYALNIFRDLIADVVTFDILLNYKYLNFFCNKLYFNITKNF 145
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BLAST of SMED30020818 vs. Planmine SMEST
Match: SMESG000003342.1 (SMESG000003342.1)

HSP 1 Score: 170.629 bits (431), Expect = 4.477e-44
Identity = 126/256 (49.22%), Postives = 159/256 (62.11%), Query Frame = 3 
Query: 1524 KAVDTLDLCKLTTSYKQTPFIELSKSSITYTSYTPCTKSISLHPTPSKHQSPAPNIKLTKSCTTFTTCSNYTPYNNENLLDNSISNNPITPTTTCDLNINYTTTSNTAQQINNNILTKSITTTQTYNMGRFYQNFLMHFNEYDNTYDTYEHNDYTPFYHSLVE----IFQSPIYNNKDTIIPTDDFYIHFITTTRPTSDINLTKSNMTFITCNDKTTVNYNLPKTFNLEHKFNYLEIYYLNNDTYDHETSSCFQPL 2279
            +A++TLD  K T+S   T  I+LSKSS T+T+Y PC K               P +KLTKS TTFTTCS    Y NENL +NSISNNPIT  +TCD N    TT++      N ILT    TTQ YNMGR+YQN  ++ +E DNTY+T++H D+ P    L +    IFQSPIY     +   D ++IH +TT RPTS I LTKSN T  TCNDKTT N+N PKT+NL +KF++ +  Y+  D YD+E  SCF P 
Sbjct:  228 EAIETLDFFKHTSS--PTSCIKLSKSSTTFTNYIPCNK--------------LPTLKLTKSNTTFTTCS---IYKNENLFENSISNNPITSPSTCDTN---YTTTSNTTPETNKILTMPPMTTQMYNMGRYYQNLTIYLDENDNTYETFDHYDFKPLCRPLGDPSDDIFQSPIYIQNGNMNQNDGYFIHSLTTKRPTSAIILTKSNTTTTTCNDKTTTNHNQPKTYNLAYKFSFTDTLYVGEDEYDYEIESCFLPF 461

HSP 2 Score: 117.472 bits (293), Expect = 9.064e-27
Identity = 75/179 (41.90%), Postives = 101/179 (56.42%), Query Frame = 3 
Query:  138 NRYHYFTLFSSEPN*SHGKSMKKFY-TLTFNSTGQKAGSDKLFNIKPQLSYFLENTNVNHFTNIRTDAPARHLPGSIDDYGNKIFENSLSELRLLTIENNADPYLIELYYMIYVFLNGSMEIPIDDAVRFWNKIKITDILGFYPSEQIDQLLTKPFELEGLQSKILYALNIFRNLIAEV 671
            NR    +L   +P   H  SMKKF  TLTF+STG K+GSDK    K   ++ L N  +N        A  ++     D     IF+ SL ELR L  EN+ DP+LIEL+Y ++VFLNG+ EI I DA R+WN+I  T       ++ +  LLTKPF  +  QS+I YAL  F++ I +V
Sbjct:   60 NRREDISLAEKKP---HKTSMKKFINTLTFDSTGPKSGSDKFSIFKQPFTFTLANAKMN-----TCPAETQNTLSPTD----TIFQTSLFELRQLAEENDHDPHLIELHYRMFVFLNGTTEITITDATRYWNEISTTCTFDANITQTMQLLLTKPFNYDDSQSRINYALKTFQDAITDV 226
[Close]
BLAST of SMED30020818 vs. Planmine SMEST
Match: SMESG000014823.1 (SMESG000014823.1)

HSP 1 Score: 138.272 bits (347), Expect = 6.229e-37
Identity = 73/135 (54.07%), Postives = 95/135 (70.37%), Query Frame = 3 
Query: 1887 TTQTYNMGRFYQNFLMHFNEYDNTYDTYEHNDYTPFYHSLVE----IFQSPIYNNKDTIIPTDDFYIHFITTTRPTSDINLTKSNMTFITCNDKTTVNYNLPKTFNLEHKFNYLEIYYLNNDTYDHETSSCFQPL 2279
            TTQTYN+GR+YQN  ++ +EYDNTY+TY+H D+ P    L +    IFQSPIY   D I   D ++IH +TT RPTSDINLTKSN+T  TCNDKTT N+N PKT+NL +KF++ +  YL  + YD+E  S + P 
Sbjct:    5 TTQTYNLGRYYQNLTIYLDEYDNTYETYDHYDFKPLCRPLGDPSDDIFQSPIYIQNDHINQNDGYFIHSLTTKRPTSDINLTKSNITITTCNDKTTTNHNEPKTYNLAYKFSFTDTIYLCQNKYDYEIESRYLPF 139
The following BLAST results are available for this feature:
BLAST of SMED30020818 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SMED30020818 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000017552.11.229e-10993.51SMESG000017552.1[more]
SMESG000012629.11.781e-9985.41SMESG000012629.1[more]
SMESG000017552.15.903e-8394.44SMESG000017552.1[more]
SMESG000003342.14.477e-4449.22SMESG000003342.1[more]
SMESG000014823.16.229e-3754.07SMESG000014823.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020818 ID=SMED30020818|Name=SMED30020818|organism=Schmidtea mediterranea sexual|type=transcript|length=3226bp
ATAGAAGGACTTACGCATCTTACCTACTAGCTTATCTATAAACCCCTTTG
TGTTTATCTTAACCGAGTCGAGAAAACCGTGGAAATCATTTACATCATTC
GACCCCTTTAACAAACCCTATCTGATGAATTACCGCCAACCGTTACCATT
ATTTCACTCTCTTTTCATCCGAACCTAATTAATCCCATGGAAAAAGCATG
AAAAAATTTTACACATTGACATTCAATAGCACCGGGCAGAAAGCCGGATC
TGATAAGTTATTTAATATTAAACCACAATTATCCTATTTTTTAGAAAACA
CAAATGTAAATCACTTTACGAACATTCGAACTGATGCCCCTGCTAGACAT
CTCCCTGGATCCATTGACGATTATGGCAATAAAATATTTGAAAATAGCCT
TTCAGAACTACGCCTTTTAACAATTGAGAATAATGCTGATCCTTACCTTA
TTGAACTCTATTACATGATTTATGTCTTCTTAAATGGTTCTATGGAAATT
CCAATAGACGATGCTGTCAGATTTTGGAACAAAATTAAAATAACCGATAT
TTTAGGCTTTTACCCATCCGAACAAATTGACCAACTCCTAACAAAGCCCT
TTGAACTGGAAGGCCTGCAATCTAAGATCCTTTATGCCTTGAATATTTTC
AGGAACTTGATTGCAGAAGTGGTAACATTTGATATATTATTAAACTATAA
ATATTTACATTTCTTTTGCAACAAACTCTATTTTAATATTACTAAAAACT
TTAAATTAATAAAATCAAATAAAAATATATCAAATAATCCCATTCTTCCC
TCGAATTTATTAGGAAATCATAATAACAAAACTATCCAAAATATTTCTCA
AAAAGACCTTGAAAATATAACACAACATGCACAAACAATAATAACACAAC
ATGCACAGCCCATTACTTATAAAAAAGTACTGATTAAAAATTTAAAAATT
AAAAACATTAAAAATAGTTTGAGTTCATTGACTAATTACACAGACAACTT
TTTTAACGAATTAAACATTCAATTATTAAATATTAAACATGTTTTGAATG
ATGAAACTTACTTTATAAAATTTTTAATTGATTATTTTTACATATTTTAT
TTAAAATTAAAATTACTTTAACAAAAATTTTCAAAATACTAACACACATT
ACCAAAATAACATACCTTTACTTTATGAAATAGGAAAGTTAACCAATAAT
TATTTTTTAAAAACTGAAAACTACTTTATAAAAATTAATAAAGATTTTAA
ACGGGATATTGATTTATTTTTAAATGATTTCTATTTTATTATTAAACATA
AAGTAAAATATTTGTTTAAATATTCCAAATTTAGTAGTTTAAATCCATGG
AAAAAGCATAAAAAAATATAGTGTACGCAGCTCGTCGGCCTGCGGCCGAC
TCACTGACCCCATAATTATTAAACCTACTAAAATTTTTTTTTCCAATGAT
GCCCTAAATAACGAAATCCTTTTTAACAAAACCTCGAAAAACCACATACC
AGATTTATGACTACAAACACAATAAAGCTGTTGATACGTTAGATCTTTGT
AAACTTACTACATCTTACAAACAAACCCCTTTTATAGAACTCAGTAAATC
ATCTATTACTTATACTTCTTACACGCCCTGCACTAAATCAATCTCTCTTC
ACCCCACGCCATCAAAACACCAATCACCTGCTCCCAACATTAAACTTACC
AAATCATGCACTACCTTTACTACCTGCTCAAACTACACACCATACAACAA
TGAAAACTTGCTTGACAACTCTATCTCTAATAACCCCATAACTCCCACAA
CTACCTGTGACTTAAACATTAATTATACTACTACTTCTAATACTGCACAA
CAAATCAACAACAATATACTTACCAAATCCATTACGACAACACAGACATA
CAACATGGGGCGCTTCTATCAAAACTTTCTAATGCATTTTAATGAATATG
ATAATACTTATGATACTTATGAACACAATGACTATACACCTTTTTACCAT
TCACTTGTTGAAATTTTCCAAAGTCCAATTTATAATAACAAAGATACCAT
AATTCCGACAGATGATTTCTACATTCACTTTATAACCACGACAAGACCAA
CGTCTGACATAAATCTCACCAAATCAAATATGACCTTTATTACATGCAAT
GATAAAACCACTGTCAACTACAATTTACCTAAGACATTCAACCTTGAACA
CAAATTCAATTACCTGGAAATCTATTATTTAAATAATGATACTTATGACC
ATGAAACTTCATCATGCTTCCAACCTCTTTACTTAAACTGGCTATATAAA
CTTAAAAAAACCCTGATACTGATACTGTATACCCCAAACAATAATTGCTC
TATAATTACTACAAATTACGACCACTCATCAAACCTAATAGAAAATGACC
TTATTACTTCATCCACCCTTAATACTAACCTAGACAAACCCGATTTTCTA
AATACTCCAACTACTGACCAAGACCCAGCAAAACAACCATGCCGTATACG
TGGCTATATATTCTGTAATTGTTGTAATGATAGTGATTATAACGATGATA
GCGATGATAGCGACTGCCCAGATGAAGACGAATACTATTCATACCATGCT
GATCCTGACTACCTATCATACATTGAAAGCCAACAATATGAAGAAGAGAG
TGATTAACTCCTGAATGCCTTGTATCCTGATGCCTGCCTGGACTCTACTC
TATGCCTGATGTAACTCCAACACATACTAAAACAAACAACTGATCCCGAA
AACCGAATAATCCGATAATGAATCTCCAAATACTGAATGCTGAATAAAAA
CCTTTGATATCACCAAAATTCCGATACATGTGACAAATACCTGATCATCT
ACCAACACCTGCTGTTTACAAATGCCAAAATACCGGAATACCGAATGCCT
GATGAAAAAAACCATTTATGATACCAAATTCTTATATGTTTGCCGAATAC
CCGATGATCTACCTACCACCTACCAGTGCCGACTACCGATTGACTATACA
AATTGCCAAACGCCGAACGTTGAACGTGACCCTCAGAGTCGTGCTAAGGG
CTGGAAATACTTTTTCCGCCTTAAAGTGTGAAAACATGAACTAAGCTAAA
AACTTTTCTAAGGGCAGAGTAATCGAACTCACCTTATGCCAAGAAGTGGC
AACCGGATTTATATTAATAAAAATTTGATTTTTTTTTGTATTTGGCCAAC
GATGAGGACGATCTCGCGGACGCCTA
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protein sequence of SMED30020818-orf-1

>SMED30020818-orf-1 ID=SMED30020818-orf-1|Name=SMED30020818-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=251bp
MGRFYQNFLMHFNEYDNTYDTYEHNDYTPFYHSLVEIFQSPIYNNKDTII
PTDDFYIHFITTTRPTSDINLTKSNMTFITCNDKTTVNYNLPKTFNLEHK
FNYLEIYYLNNDTYDHETSSCFQPLYLNWLYKLKKTLILILYTPNNNCSI
ITTNYDHSSNLIENDLITSSTLNTNLDKPDFLNTPTTDQDPAKQPCRIRG
YIFCNCCNDSDYNDDSDDSDCPDEDEYYSYHADPDYLSYIESQQYEEESD
*
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protein sequence of SMED30020818-orf-2

>SMED30020818-orf-2 ID=SMED30020818-orf-2|Name=SMED30020818-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=308bp
MKKFYTLTFNSTGQKAGSDKLFNIKPQLSYFLENTNVNHFTNIRTDAPAR
HLPGSIDDYGNKIFENSLSELRLLTIENNADPYLIELYYMIYVFLNGSME
IPIDDAVRFWNKIKITDILGFYPSEQIDQLLTKPFELEGLQSKILYALNI
FRNLIAEVVTFDILLNYKYLHFFCNKLYFNITKNFKLIKSNKNISNNPIL
PSNLLGNHNNKTIQNISQKDLENITQHAQTIITQHAQPITYKKVLIKNLK
IKNIKNSLSSLTNYTDNFFNELNIQLLNIKHVLNDETYFIKFLIDYFYIF
YLKLKLL*
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