Required for meiotic nuclear division protein 1 homolog

Overview
NameRequired for meiotic nuclear division protein 1 homolog
Smed IDSMED30020766
Length (bp)1252
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Required for meiotic nuclear division protein 1 homolog (SMED30020766) t-SNE clustered cells

Violin plots show distribution of expression levels for Required for meiotic nuclear division protein 1 homolog (SMED30020766) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Required for meiotic nuclear division protein 1 homolog (SMED30020766) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Required for meiotic nuclear division protein 1 homolog (SMED30020766) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020766

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30020766SMESG000006964.1 SmedASXL_018267SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
parenchymaSMED30020766SMESG000006964.1 Contig33228newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30020766SMESG000006964.1 Contig33228uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Human
Match: RMND1 (required for meiotic nuclear division 1 homolog [Source:HGNC Symbol;Acc:HGNC:21176])

HSP 1 Score: 117.857 bits (294), Expect = 1.186e-29
Identity = 82/261 (31.42%), Postives = 138/261 (52.87%), Query Frame = 2 
Query:  281 YLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
            + TA   +DE ++  +   L +   V+  SLP +   +   G      + D  T F F  G   FW+         M + E+ EI    +P+++  ++ + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS+  R++++NEKL    ELT+++RNH+
Sbjct:    2 HCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEI----QPYEIALVH-WENEE--LNYIKIEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKV--KLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL 250
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Human
Match: RMND1 (required for meiotic nuclear division 1 homolog [Source:HGNC Symbol;Acc:HGNC:21176])

HSP 1 Score: 117.472 bits (293), Expect = 2.651e-28
Identity = 82/261 (31.42%), Postives = 138/261 (52.87%), Query Frame = 2 
Query:  281 YLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
            + TA   +DE ++  +   L +   V+  SLP +   +   G      + D  T F F  G   FW+         M + E+ EI    +P+++ ++  + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS+  R++++NEKL    ELT+++RNH+
Sbjct:  172 HCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEI----QPYEI-ALVHWENEE--LNYIKIEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKV--KLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL 420
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Human
Match: RMND1 (required for meiotic nuclear division 1 homolog [Source:HGNC Symbol;Acc:HGNC:21176])

HSP 1 Score: 96.2857 bits (238), Expect = 5.058e-21
Identity = 72/242 (29.75%), Postives = 123/242 (50.83%), Query Frame = 2 
Query:  281 YLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRI 973
            + TA   +DE ++  +   L +   V+  SLP +   +   G      + D  T F F  G   FW+         M + E+ EI    +P+++ ++  + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS+  R+++
Sbjct:  172 HCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEI----QPYEI-ALVHWENEE--LNYIKIEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKV--KLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKV 401
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Celegans
Match: ZK1010.2 (pep chromosome:WBcel235:III:12975068:12977862:-1 gene:WBGene00014176.1 transcript:ZK1010.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ZK1010.2)

HSP 1 Score: 84.3445 bits (207), Expect = 1.063e-17
Identity = 55/210 (26.19%), Postives = 110/210 (52.38%), Query Frame = 2 
Query:  440 FIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYD---YMNEEDFLPYFYHNDKTK--VNKDAIYLKIPH--SQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHST 1048
            F+F  GV+ FW+++  +RS I+   + +  ++ YD    M+E+D + Y +    T   + +D  YL   H  +     + I ++ A+S+  + SVK+G++ES     +  ++     +  G+  +++    + L ++GE   +RH IN+   +    D YW++ +LE  +    R  S+  RI +LN++L+   EL +++ N IA  H++
Sbjct:  124 FVFRDGVVVFWNVDSSQRSHILRELERY-ADAPYDSMIVMDEQDRMFYKFSEQSTGSTIRQDRFYLSGKHLDAFHGSNEAILERFALSQGFAASVKIGVWESLLNNLAEPLSNTTKSLTLGKIPWSRK---QALMRSGEFAALRHSINLDCTLLN-KDFYWERPELEKYYTMTGRHFSLDRRIGLLNKRLDYCEELVKMVDNTIALRHAS 328
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Fly
Match: CG11679 (gene:FBgn0030678 transcript:FBtr0074202)

HSP 1 Score: 99.7525 bits (247), Expect = 1.057e-22
Identity = 63/242 (26.03%), Postives = 117/242 (48.35%), Query Frame = 2 
Query:  392 LTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYM--NEEDFLPYFY-HNDKTKVNKDAIYLKIPHSQEQEYKLIEQQM-------------------AMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            L    +Y T    +  F F  G + FW+ +  E + +++  + F+  S    +   E + +PY Y  +    V  D +      ++  ++ +  +                       S A++QS+KLG++E+  + +  SI    + +K GR    +I    +L+KTGELF +RH IN+SS + + PD YW + +LE L+ Q+    S+S R +++NEK+N   EL E++ +++   H  +
Sbjct:  143 LFVAAKYPTGQQPREIFFFREGSVVFWNCSDIETNNVLSFLRAFERESYVSALVHGESEVMPYTYIPSTAVDVEGDLV------AESSDFNVTSRAFFQNGKFFVTADTDSFLYKYTFSNAMAQSIKLGMWEATLDRYIDSIEHLTEDLKRGRRL--RISRAAMLRKTGELFALRHVINLSSDLLDAPDFYWDREELEALYLQVCSYFSISRRTKVMNEKINHCVELAELVSHNLNDAHHIR 376
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Zebrafish
Match: rmnd1 (required for meiotic nuclear division 1 homolog [Source:ZFIN;Acc:ZDB-GENE-050522-21])

HSP 1 Score: 117.857 bits (294), Expect = 7.307e-29
Identity = 77/219 (35.16%), Postives = 129/219 (58.90%), Query Frame = 2 
Query:  425 DRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEY-KLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            D  T F F  G + FW+         M I E+ EI    +P++V  +Y + NEE  + Y      +K+ +  ++L    ++E +Y ++I ++ A S ALS SVKL I+E   + F  SI    + +KSG+    K+   +V++K GELF++RH IN+SS +   PD YW + DLE L+D+  + L+++ R++++NEKL   +ELT+++RNH++  HS +
Sbjct:  183 DSGTIFFFREGSVVFWNVEDKTMKTTMKILEQHEI----QPYEVALVY-WENEE--INYTVGEGHSKL-RHGVFL---FNEELDYEQVILEKFAFSNALSLSVKLAIWEVTLDSFVESIQSIPEMLKSGQRV--KLSRADVMQKIGELFSLRHCINLSSDLLITPDFYWDREDLELLYDKTCQFLNINRRVKVVNEKLQHCTELTDLMRNHLSEKHSLR 388
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Xenopus
Match: RMND1 (required for meiotic nuclear division 1 homolog [Source:NCBI gene;Acc:101733789])

HSP 1 Score: 122.865 bits (307), Expect = 1.297e-31
Identity = 83/266 (31.20%), Postives = 146/266 (54.89%), Query Frame = 2 
Query:  287 TACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTY--CGQYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            TA   +DE ++ T+   L +   ++  SLP +   +            D  T F F  G + FW+         + I ER EI    +P++V  ++ + NEE  + Y + +  TK+ K  I L    +Q +  ++I ++ A S AL  SVKL I+E+  + F +SI    + +K+ +    K+   +V++K GELF +RH+IN+SS +   PD YW + +LE+L+D+  + LS++ R++++NEKL   +ELT+++RNH+   H+ +
Sbjct:    4 TAFATADEYHLGTLSHDLASHGYLELPSLPRDASNVLLFEVDNGAKDTDSGTVFFFREGAVVFWNVEERIMKHTLQILERHEI----QPYEVALVH-WENEE--INYSFGDGHTKLVKGEIVLN---TQLELEEVILEKFAFSNALCLSVKLAIWEATLDTFVSSIQSIPEMLKARKKV--KLSHDDVMQKIGELFALRHRINLSSDLLITPDFYWDRENLEHLYDKTCQFLSINRRVKVINEKLQHCTELTDLMRNHLNEKHALR 257
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Xenopus
Match: RMND1 (required for meiotic nuclear division 1 homolog [Source:NCBI gene;Acc:101733789])

HSP 1 Score: 122.094 bits (305), Expect = 2.450e-30
Identity = 87/285 (30.53%), Postives = 155/285 (54.39%), Query Frame = 2 
Query:  242 SSVTNESNISEKKYLTAC---CVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCGQYKTKIDRKTFFIF---HGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
             S TN+  +SE   L  C     +DE ++ T+   L +   ++  SLP     +   G Y  ++     F+      G + FW+         + I ER EI    +P++V ++  + NEE  + Y + +  TK+ K  I L   ++Q +  ++I ++ A S AL  SVKL I+E+  + F +SI    + +K+ +    K+   +V++K GELF +RH+IN+SS +   PD YW + +LE+L+D+  + LS++ R++++NEKL   +ELT+++RNH+   H+ +
Sbjct:  110 PSRTNQPLLSETTDLMQCTAFATADEYHLGTLSHDLASHGYLELPSLPRGT--VLILGTYIMEVQEAAVFVHSFSQEGAVVFWNVEERIMKHTLQILERHEI----QPYEV-ALVHWENEE--INYSFGDGHTKLVKGEIVL---NTQLELEEVILEKFAFSNALCLSVKLAIWEATLDTFVSSIQSIPEMLKARKKV--KLSHDDVMQKIGELFALRHRINLSSDLLITPDFYWDRENLEHLYDKTCQFLSINRRVKVINEKLQHCTELTDLMRNHLNEKHALR 380
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Mouse
Match: Rmnd1 (required for meiotic nuclear division 1 homolog [Source:MGI Symbol;Acc:MGI:1913334])

HSP 1 Score: 122.479 bits (306), Expect = 2.973e-30
Identity = 88/277 (31.77%), Postives = 147/277 (53.07%), Query Frame = 2 
Query:  242 SSVTNESNISEKKYLTAC---CVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
             S TN  ++S  + L  C     +DE ++ ++   L +   V+  SLP +   +   G      + D  T F+F  G   FW+         M + ER E    T+P++V ++  + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS++ R++++NEKL    ELT+++RNH+
Sbjct:  157 PSRTNLPDLSVNEDLMQCTAFATADEYHLGSLSQELVSCGYVEVTSLPRDAANILVMGVESSAKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQVLERHE----TQPYEV-ALVHWENEE--LNYIKTEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKV--KLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 421
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Mouse
Match: Rmnd1 (required for meiotic nuclear division 1 homolog [Source:MGI Symbol;Acc:MGI:1913334])

HSP 1 Score: 55.8398 bits (133), Expect = 1.468e-9
Identity = 25/58 (43.10%), Postives = 41/58 (70.69%), Query Frame = 2 
Query:  857 INVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
            IN+SS     PD YW + +LE L+D+  + LS++ R++++NEKL    ELT+++RNH+
Sbjct:    1 INLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 58
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Match: sp|Q8CI78|RMND1_MOUSE (Required for meiotic nuclear division protein 1 homolog OS=Mus musculus OX=10090 GN=Rmnd1 PE=1 SV=1)

HSP 1 Score: 122.479 bits (306), Expect = 2.080e-29
Identity = 88/277 (31.77%), Postives = 147/277 (53.07%), Query Frame = 2 
Query:  242 SSVTNESNISEKKYLTAC---CVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
             S TN  ++S  + L  C     +DE ++ ++   L +   V+  SLP +   +   G      + D  T F+F  G   FW+         M + ER E    T+P++V ++  + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS++ R++++NEKL    ELT+++RNH+
Sbjct:  157 PSRTNLPDLSVNEDLMQCTAFATADEYHLGSLSQELVSCGYVEVTSLPRDAANILVMGVESSAKEGDPGTIFLFREGAAVFWNVKEKTMKHVMQVLERHE----TQPYEV-ALVHWENEE--LNYIKTEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEATLDKFIESIQSIPEALKAGKKV--KLSHKEVMQKMGELFALRHRINLSSDFLITPDFYWDRANLEELYDKTCQFLSITRRVKVMNEKLQHCMELTDLMRNHL 421
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Match: sp|Q9NWS8|RMND1_HUMAN (Required for meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=RMND1 PE=1 SV=2)

HSP 1 Score: 117.472 bits (293), Expect = 1.273e-27
Identity = 82/261 (31.42%), Postives = 138/261 (52.87%), Query Frame = 2 
Query:  281 YLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
            + TA   +DE ++  +   L +   V+  SLP +   +   G      + D  T F F  G   FW+         M + E+ EI    +P+++ ++  + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS+  R++++NEKL    ELT+++RNH+
Sbjct:  172 HCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEI----QPYEI-ALVHWENEE--LNYIKIEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKV--KLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHL 420
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Match: sp|Q5RAR5|RMND1_PONAB (Required for meiotic nuclear division protein 1 homolog OS=Pongo abelii OX=9601 GN=RMND1 PE=2 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 8.757e-27
Identity = 81/261 (31.03%), Postives = 137/261 (52.49%), Query Frame = 2 
Query:  281 YLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCG--QYKTKIDRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHI 1030
            + TA   +DE ++  +   L +   V+  SLP +   +   G      + D  T F F  G   FW+         M + E+ EI    +P+++  ++ + NEE  L Y     ++K+++  I L   +S+      I ++ A S AL  SVKL I+E+  + F  SI    + +K+G+    K+   EV++K GELF +RH+IN+SS     PD YW + +LE L+D+  + LS+  R++++NEKL    E T+++RNH+
Sbjct:  172 HCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEI----QPYEIALVH-WENEE--LNYIKIEGQSKLHRGEIKL---NSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKV--KLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMEPTDLMRNHL 420
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Match: sp|O74446|SIF2_SCHPO (Sad1-interacting factor 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sif2 PE=1 SV=2)

HSP 1 Score: 68.9366 bits (167), Expect = 2.061e-11
Identity = 50/209 (23.92%), Postives = 102/209 (48.80%), Query Frame = 2 
Query:  431 KTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSI-YDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDK----MKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMH 1042
            +  F F  GV+  W   IDE    +     F++  +  + M  E+F  Y     + ++  D I L+        Y +   ++++S A++QSVK+ ++E   E+ + +I+   D      ++GR     +K  E++   G+LF +R  IN+   + + P++ W +  LE ++   R  L ++ R+ +LN+++ +  +L  +L+  I   H
Sbjct:  156 REVFCFTYGVVVLWGYTIDEEHRFLRELGRFEIEKLKIEDMEVEEFNYYITTLYQPRIFNDFIALR----DASNYMI---RLSISHAIAQSVKISLFE---ELVNETIDATKDTPQMIAETGRV---NLKREEIMMAVGQLFILRININLQGSVLDSPELMWTEPQLEPIYTAARSYLEINQRVALLNQRVEVIGDLLSMLKEQITHTH 351
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Match: sp|Q05648|MRX10_YEAST (MIOREX complex component 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MRX10 PE=1 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 4.601e-11
Identity = 49/156 (31.41%), Postives = 76/156 (48.72%), Query Frame = 2 
Query:  668 QMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKXXXXXXXXXXXXXXXXCFS---FYEKYS 1126
            + A S  LS+S  L + E   E   +      + +  G      ++  + LK  G LF +R K+N+ S + E PD+YW +  LE +F  + R L +  RI ILN KL+ YS  T+  R  I+ ++      +  I+I +     CF    FY+KYS
Sbjct:  249 KAAFSSGLSRSTNLAVLEEAMEKHISKTRTITENISKGTKL--NLRSSDALKSIGRLFLIRGKLNLYSELIETPDLYWSEPQLEEIFKNVSRYLDIGPRINILNSKLD-YS--TDECRALISLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYS 399
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Match: A0A3Q0KIN3 (DUF155 domain-containing protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 149.828 bits (377), Expect = 3.939e-37
Identity = 92/282 (32.62%), Postives = 157/282 (55.67%), Query Frame = 2 
Query:  314 NIKTIKSFLKNVDNV-KELSLPAEIQRLTYCGQYKTKIDRKT-----FFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIP----------HSQEQEYK---------------LIE-----QQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            ++K ++S+L   DN+ K  +LP+E+          ++I+ +       FIF+ GV  FW+M  +    ++   + F    + + + E + L Y   ND+T+V  + IYL IP            ++Q YK               L E     ++ A S+AL+ SVKL + E+ F+     I  WI+KMK+GR    + ++  VL+KTGEL+T++H +NVS+ + E PD YW++ D+E LF++++  LS+SSRI++LN +L++ +ELT +L NH+  +HS +
Sbjct:  109 DLKMLRSYLSKFDNLYKFPTLPSELSSEVLLISQLSEINTENNNPWDAFIFNNGVAVFWNMPEENHQSLLKEFRQFSEGILEENLIEREDLRYCLTNDQTRVVGEDIYLHIPSLKDVSHHTEQQRQQSYKDLTLEDQFSKLASASLTEDNSLLEKFAFSDALALSVKLSLLENGFDTAVVEIEPWIEKMKTGRG--ARFRQSAVLRKTGELYTIKHLLNVSTSLIETPDFYWERPDVEKLFEKLKYVLSVSSRIKVLNSRLDMCNELTSILTNHLCSVHSVR 388
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Match: A0A094ZXQ6 (Calcineurin-like phosphoesterase domain-containing protein 1 OS=Schistosoma haematobium OX=6185 GN=MS3_06340 PE=4 SV=1)

HSP 1 Score: 150.599 bits (379), Expect = 7.018e-36
Identity = 91/279 (32.62%), Postives = 156/279 (55.91%), Query Frame = 2 
Query:  314 NIKTIKSFLKNVDNV-KELSLPAEIQRLTYCGQYKTKIDRKTF-----FIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIP-------HSQEQEYKLIEQQ--------------------MAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            N+K + S+L   D++ K  +LP+E+          +KID +       FIF+ GV  FW+M  +    ++   + F    + + + E + L Y   ND T+V  + IYL IP       H+++Q +K +  Q                     A S+AL+ SVKL + E+ F+     I  WI+KMK+GR    + ++  VL+KTGEL+T++H +NVS+ + E PD YW++ ++E LF++++  LS+SSR+++LN +L++ +ELT +L NH++ +HS +
Sbjct:  438 NLKMLHSYLSKFDHLYKFPTLPSELSSEVLLVSQLSKIDTENINPWDAFIFNNGVAVFWNMPEENHQLLLKEFRQFSEGILEENLIEREDLRYCLTNDHTRVVSEDIYLHIPSFEDVSHHTEQQSHKDLTLQDQYPKVASTPLTDDNSLLEKFAFSDALALSVKLSLLENGFDTAVVEIEPWIEKMKTGRG--ARFRQSAVLRKTGELYTIKHLLNVSTSLIETPDFYWERPNVEKLFEKLKCVLSVSSRVKVLNSRLDMCNELTSILTNHLSSIHSVR 714
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Match: A0A564Z354 (DUF155 domain-containing protein (Fragment) OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS12034 PE=4 SV=1)

HSP 1 Score: 140.198 bits (352), Expect = 7.543e-34
Identity = 84/244 (34.43%), Postives = 134/244 (54.92%), Query Frame = 2 
Query:  365 LSLPAEIQR----LTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLK-IP------HSQE----QEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            L LP E+       T        +  +   +F  GV+ FW+++  E  EIIN+ +      I   + E + L Y + +  T ++ + I L+ +P       SQE    +  +L+ +++A S+AL+ SVKL + E+ F+  +  +  WIDKM+ G   F  +    V +KTGELFT+RH +N+S+ I+E PD YW + ++E LF  ++  LS+ SR  ILN KLN   ELTE+L NH+   HS++
Sbjct:  114 LRLPPEVANEILFFTTPSDVHDPVSHRDILVFKTGVVVFWNVSDSESEEIINVFRNECNRPIALELIEFEELVYSFTSGPTMLDVEDIRLRAVPAKSDSKESQEVYEKEIQRLVMEKIAFSDALAASVKLALLETSFDAVAVQMQPWIDKMQIGLGAFFPMSA--VFRKTGELFTLRHLLNISTTISETPDFYWDRPEVEKLFQNLKNALSVQSRTHILNSKLNTCCELTEILTNHLEARHSSR 355
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Match: A0A068YBQ6 (Required for meiotic nuclear division protein 1 OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000718100 PE=4 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 1.112e-33
Identity = 81/244 (33.20%), Postives = 130/244 (53.28%), Query Frame = 2 
Query:  365 LSLPAEIQR----LTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKI--PHSQEQEYK---------LIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            L LP E+ +    L+           +   +F  GV+ FW+++  E  E I   +      I     E + L Y + +  T+++ + I L    P S   E +         L  +++A S+AL+ SVKL + E+ F+  +  +  WIDKM++G   F  +    V++KTGELFT+RH +N+S+ I+E PD YW ++D+E LF  ++  LS+ SR RILN KL+   EL E+L NH+   HS++
Sbjct:    6 LRLPPEVTKEIIFLSTLFDVNDPTKHRDILVFKTGVVVFWNVSESECEETITKIRKECNRPISPEAVEFEELIYSFTSGPTRLDVEDIRLHALPPRSDANESQDAYEKAVQTLAIEKIAFSDALASSVKLSLLENSFDAVAVQMQPWIDKMQTGLGMFFPMSS--VIRKTGELFTLRHLLNISTTISETPDFYWDRSDVEKLFQNLKSALSVRSRTRILNSKLDTCCELAEILTNHLQARHSSR 247
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Match: A0A5K3FBY4 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 138.658 bits (348), Expect = 2.149e-33
Identity = 83/252 (32.94%), Postives = 127/252 (50.40%), Query Frame = 2 
Query:  365 LSLPAEIQR----LTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTK-----PFQVNSI------YDYMNEEDFL--------PYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            L LP E+      LT  G        +   +F  GVI FW+++  E  E++   +     P   N +      Y + +E  +L              D T       Y K+ H+Q  E      ++A S+AL+ SVKL + E+ F+  +  +  WI+KM++G   F  +    V +KTGELFT+RH +N+S+ I+E PD YW + ++E LF  ++  LS+ SR  ILN KLN   ELTE+L NH+   HS++
Sbjct:   92 LRLPPEVANEILFLTTPGDADDPRIHRDILVFKTGVIVFWNVSNSECEELVGKVRQQCNSPIAPNLVEFEELFYSFTSEPTYLDVEDIRLHAIPSRQDATTAESPGGYEKLVHNQALE------KVAFSDALASSVKLSLLETSFDAVAVQMQPWIEKMQTGLGVFFPVSA--VFRKTGELFTLRHLLNISTTISETPDFYWDRPEVEKLFQNLKSALSVQSRTNILNSKLNTCCELTEILTNHLEARHSSR 335
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Cavefish
Match: rmnd1 (required for meiotic nuclear division 1 homolog [Source:NCBI gene;Acc:103045364])

HSP 1 Score: 110.923 bits (276), Expect = 2.343e-26
Identity = 75/218 (34.40%), Postives = 119/218 (54.59%), Query Frame = 2 
Query:  425 DRKTFFIFHGGVISFWD---------MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            D    F F  G + FW+         M I E+ EI    +P++V ++  + NEE  + Y      +K+ +           EQ+   I ++ A S ALS SVKL I+E   + F  SI    + +KSG+    K+   EVL+K GELF +R+ IN+SS +   PD YW + DLE L+D+  + L+++ R++++NEKL   +ELT+++RNH+   HS +
Sbjct:  207 DTAMIFFFREGSVVFWNVTEKDVKKVMRILEQHEI----QPYEV-ALVHWENEE--INYTVGEGNSKLYRGNFIFNAEMDYEQQ---ILEKFAFSNALSLSVKLAIWEISLDNFVESIQSIPETLKSGKTV--KLSRAEVLQKIGELFALRYCINLSSDLLITPDFYWDREDLEQLYDKTCQFLNINRRVKVVNEKLQHCTELTDLMRNHLGEKHSLR 412
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Yeast
Match: MRX10 (Mitochondrial inner membrane protein of unknown function; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation [Source:SGD;Acc:S000002690])

HSP 1 Score: 67.781 bits (164), Expect = 6.626e-13
Identity = 49/156 (31.41%), Postives = 76/156 (48.72%), Query Frame = 2 
Query:  668 QMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKXXXXXXXXXXXXXXXXCFS---FYEKYS 1126
            + A S  LS+S  L + E   E   +      + +  G      ++  + LK  G LF +R K+N+ S + E PD+YW +  LE +F  + R L +  RI ILN KL+ YS  T+  R  I+ ++      +  I+I +     CF    FY+KYS
Sbjct:  249 KAAFSSGLSRSTNLAVLEEAMEKHISKTRTITENISKGTKL--NLRSSDALKSIGRLFLIRGKLNLYSELIETPDLYWSEPQLEEIFKNVSRYLDIGPRINILNSKLD-YS--TDECRALISLLNERNSTFLEWIIIYLIAFELCFEIYHFYQKYS 399
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Yeast
Match: RMD1 (Cytoplasmic protein required for sporulation [Source:SGD;Acc:S000002159])

HSP 1 Score: 67.3958 bits (163), Expect = 1.092e-12
Identity = 50/204 (24.51%), Postives = 102/204 (50.00%), Query Frame = 2 
Query:  437 FFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDY-MNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFE-VFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMH 1042
             FIF  GV+  W     E    +N  + F+   + +  +  E+F  Y   + + ++  D I L+        Y +   ++++S A++QSVK+ ++E   +     + +I  +   SG+   +K    +++K  GELF +R  IN+   + + P+I W +  LE ++   R  L ++ R+ +LN++L + S+L ++L+  +   H
Sbjct:  205 LFIFEYGVVVMWGFTEREEKAFLNDIEKFEKEKLAEEDIQVEEFNYYVTKSYQPRIYNDFITLR----DGSNYMV---KLSISHAIAQSVKISLFEELVDNTIEDTQDIPQEIAYSGKVSMSK---EDIMKSIGELFILRININLHGSVLDSPEIMWSEPQLEPIYQATRGYLEINQRVSLLNQRLEVISDLLQMLKEQLGHSH 398
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Yeast
Match: RMD8 (Cytosolic protein required for sporulation [Source:SGD;Acc:S000001944])

HSP 1 Score: 67.781 bits (164), Expect = 1.228e-12
Identity = 54/208 (25.96%), Postives = 108/208 (51.92%), Query Frame = 2 
Query:  440 FIFHGGVISFWDMN-IDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYH------NDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFN--KIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQ-KNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIA 1033
            FIFH GVI FW+   I E++ + ++T     N +   ++E+D     +H       ++ ++  D + L+          +IE  + +S A++QS KL  +ES+     + I I + K+      +    +K  ++LKK+G+LF +R  +N+SS I + P+ +W  +  L  L+  +R  L +  R+++LN++  ++ E  ++  + +A
Sbjct:  428 FIFHYGVIVFWNFTEIQEKNILGDITFADYKNLMIRPLDEQDIETEQFHFEYDRDTERPRIFNDIVTLR------SGDHIIE--LTLSHAIAQSSKLSRFESRI----SPILISVTKLPKRLALYGTLGLKREQLLKKSGKLFKLRVDVNLSSTILDTPEFFWSFEPSLHPLYVAMREYLEIDQRVQVLNDRCKVFLEFFDICVDSVA 623
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Nematostella
Match: EDO37696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SF12])

HSP 1 Score: 103.605 bits (257), Expect = 9.339e-26
Identity = 69/201 (34.33%), Postives = 109/201 (54.23%), Query Frame = 2 
Query:  458 VISFWDMNIDERSEIINMTKPFQ-----VNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHS 1045
             + FW++   E  +I  +T  F+      ++I D   E + LP+ Y    T + K  I L      E E K +E+  A S A++ S+KLG++ES  E +  SI    + +  G     K+   EVL KTGEL ++R+KIN+SS +   PD YW ++ LE L+D +   + +  R +++NEKL   SEL ++LR H++  HS
Sbjct:    2 ALVFWNVEQSEMQKIRKLTARFEEGRYNRDTIED---ESEELPFTYSGSPTSLVKGRINLN--SESEPETKPLEK-FAFSHAVALSIKLGMWESVLEKYIDSIAWVPEALSKGEPL--KLSRNEVLVKTGELISLRYKINLSSDLLMTPDFYWDRDSLEGLYDTMCSYMDIRRRTKVMNEKLTHCSELADLLRTHLSERHS 194
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Medaka
Match: rmnd1 (required for meiotic nuclear division 1 homolog [Source:NCBI gene;Acc:101170484])

HSP 1 Score: 109.383 bits (272), Expect = 3.893e-26
Identity = 76/261 (29.12%), Postives = 140/261 (53.64%), Query Frame = 2 
Query:  290 ACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQR-LTYCGQYKTKI-DRKTFFIFHGGVISFWDMNIDERSEIINM-----TKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTK 1051
            A   +D+ ++ T+   L N    +E+ LP +    L    +   K  D    F F  G + FW++      +++ +      +P++V  ++ + NEE  + Y      T++ +   +L +  SQ++    + ++ A S AL  SVKL I+E   + F  SI    + +KSG+    ++   EV++K GELFT+RH IN+ S +   PD YW + +LE L+++  + LS++ R+ ++NEKL   S+LT+++R+H++  HS +
Sbjct:  112 AFATADQYHLPTLCHDLTN-HGFQEIDLPRDASNVLGMSTETAAKPEDDALMFFFREGSVVFWNVEEKTMKQVLRVLEHHEIQPYEVALVH-WENEE--INYTLGEGNTRLERGDFFLSLDISQQEA---VLEKFAFSNALCLSVKLAIWEVALDSFVESIQSIPETLKSGKRI--RLSSAEVMQKIGELFTLRHCINLRSDLLITPDFYWDRENLEKLYEKTCQFLSINRRVNVVNEKLEHCSQLTDLMRSHLSEKHSLR 363
[Close]
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Planmine SMEST
Match: SMESG000006964.1 (SMESG000006964.1)

HSP 1 Score: 587.415 bits (1513), Expect = 0.000e+0
Identity = 305/305 (100.00%), Postives = 305/305 (100.00%), Query Frame = 2 
Query:  242 SSVTNESNISEKKYLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKXXXXXXXXXXXXXXXXCFSFYEKYSVNSELNFEKT 1156
            SSVTNESNISEKKYLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKLEIMIIILILIEVIFECFSFYEKYSVNSELNFEKT
Sbjct:   23 SSVTNESNISEKKYLTACCVSDEINIKTIKSFLKNVDNVKELSLPAEIQRLTYCGQYKTKIDRKTFFIFHGGVISFWDMNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLKIPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMKSGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYLFDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKLEIMIIILILIEVIFECFSFYEKYSVNSELNFEKT 327
The following BLAST results are available for this feature:
BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
RMND11.186e-2931.42required for meiotic nuclear division 1 homolog [S... [more]
RMND12.651e-2831.42required for meiotic nuclear division 1 homolog [S... [more]
RMND15.058e-2129.75required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ZK1010.21.063e-1726.19pep chromosome:WBcel235:III:12975068:12977862:-1 g... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG116791.057e-2226.03gene:FBgn0030678 transcript:FBtr0074202[more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rmnd17.307e-2935.16required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
RMND11.297e-3131.20required for meiotic nuclear division 1 homolog [S... [more]
RMND12.450e-3030.53required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Rmnd12.973e-3031.77required for meiotic nuclear division 1 homolog [S... [more]
Rmnd11.468e-943.10required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8CI78|RMND1_MOUSE2.080e-2931.77Required for meiotic nuclear division protein 1 ho... [more]
sp|Q9NWS8|RMND1_HUMAN1.273e-2731.42Required for meiotic nuclear division protein 1 ho... [more]
sp|Q5RAR5|RMND1_PONAB8.757e-2731.03Required for meiotic nuclear division protein 1 ho... [more]
sp|O74446|SIF2_SCHPO2.061e-1123.92Sad1-interacting factor 2 OS=Schizosaccharomyces p... [more]
sp|Q05648|MRX10_YEAST4.601e-1131.41MIOREX complex component 10 OS=Saccharomyces cerev... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3Q0KIN33.939e-3732.62DUF155 domain-containing protein OS=Schistosoma ma... [more]
A0A094ZXQ67.018e-3632.62Calcineurin-like phosphoesterase domain-containing... [more]
A0A564Z3547.543e-3434.43DUF155 domain-containing protein (Fragment) OS=Hym... [more]
A0A068YBQ61.112e-3333.20Required for meiotic nuclear division protein 1 OS... [more]
A0A5K3FBY42.149e-3332.94Uncharacterized protein OS=Mesocestoides corti OX=... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rmnd12.343e-2634.40required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3
Match NameE-valueIdentityDescription
MRX106.626e-1331.41Mitochondrial inner membrane protein of unknown fu... [more]
RMD11.092e-1224.51Cytoplasmic protein required for sporulation [Sour... [more]
RMD81.228e-1225.96Cytosolic protein required for sporulation [Source... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO376969.339e-2634.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rmnd13.893e-2629.12required for meiotic nuclear division 1 homolog [S... [more]
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BLAST of Required for meiotic nuclear division protein 1 homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000006964.10.000e+0100.00SMESG000006964.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020766 ID=SMED30020766|Name=Required for meiotic nuclear division protein 1 homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1252bp
CAACTATATAAGCGTGGTTAATATTTAATATATTAAATTAAATTTTTTAA
AAAATATTTTGTAATAATAATGAAAGTATTTATATAAACTTAAAAAAAAA
TTGTTTTTTCTAAATTTAGGTAATAAGGACTCTATTAATATAGTATTATT
TTATAAAGACTACAATTTAATTTTTATGATTAAATTAAATAACGTTCGTA
ATTTTTTAAATTTAAACTTTTTATTAAACTATCGCTTGTTATCTAGTGTT
ACTAATGAGAGTAACATTTCTGAGAAGAAATATCTAACTGCATGTTGTGT
AAGTGACGAAATCAATATAAAAACGATCAAGAGCTTTCTTAAAAATGTGG
ATAATGTTAAAGAATTATCTTTACCCGCTGAAATCCAACGATTGACCTAT
TGTGGTCAATATAAAACAAAAATTGATCGGAAAACGTTCTTCATATTTCA
TGGTGGTGTAATATCGTTCTGGGATATGAATATCGATGAGCGATCAGAAA
TCATTAATATGACGAAGCCCTTTCAAGTAAATTCTATATATGATTATATG
AACGAGGAAGACTTCTTGCCATATTTTTATCATAATGACAAAACTAAAGT
CAATAAAGACGCAATTTATTTAAAAATTCCCCATTCCCAAGAACAAGAAT
ACAAGTTAATTGAACAGCAAATGGCCATGTCTGAAGCACTATCTCAAAGC
GTCAAATTAGGGATTTATGAATCACAATTTGAAGTTTTCAGCACATCTAT
TAATATTTGGATCGATAAAATGAAATCCGGGCGTAATTTTTTCAATAAAA
TCAAAGAATGGGAAGTTCTAAAAAAAACTGGTGAGCTATTTACCATGCGG
CACAAAATCAATGTCAGTAGTCACATAACTGAGGTTCCTGATATTTATTG
GCAGAAAAATGATTTAGAATACTTATTCGATCAAATTCGGCGAGATTTAA
GTATGTCTTCTCGAATACGAATTCTCAATGAGAAATTGAACTTGTACAGT
GAACTAACGGAAGTTTTGAGGAATCACATCGCTTTTATGCATTCCACCAA
GTTGGAAATCATGATCATTATATTAATTCTGATAGAGGTCATTTTTGAAT
GCTTTTCCTTCTATGAGAAATATTCAGTAAATTCAGAGCTGAACTTTGAG
AAAACCTAGAATATACTTTTAATTAGTAATAGCCTTTTATAATCATTTTC
TGTACAAATGATATTGTTGTAAATAAATTTTTTTAATTACTTTGAAAAAT
AA
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protein sequence of SMED30020766-orf-1

>SMED30020766-orf-1 ID=SMED30020766-orf-1|Name=SMED30020766-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=328bp
MIKLNNVRNFLNLNFLLNYRLLSSVTNESNISEKKYLTACCVSDEINIKT
IKSFLKNVDNVKELSLPAEIQRLTYCGQYKTKIDRKTFFIFHGGVISFWD
MNIDERSEIINMTKPFQVNSIYDYMNEEDFLPYFYHNDKTKVNKDAIYLK
IPHSQEQEYKLIEQQMAMSEALSQSVKLGIYESQFEVFSTSINIWIDKMK
SGRNFFNKIKEWEVLKKTGELFTMRHKINVSSHITEVPDIYWQKNDLEYL
FDQIRRDLSMSSRIRILNEKLNLYSELTEVLRNHIAFMHSTKLEIMIIIL
ILIEVIFECFSFYEKYSVNSELNFEKT*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR003734DUF155
IPR011528NERD
Vocabulary: molecular function
TermDefinition
GO:0003674molecular_function
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
Vocabulary: biological process
TermDefinition
GO:0006412translation
GO:0070131positive regulation of mitochondrial translation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR003734Domain of unknown function DUF155PFAMPF02582DUF155coord: 89..268
e-value: 9.4E-36
score: 123.5
NoneNo IPR availablePANTHERPTHR16255:SF1REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOGcoord: 30..320
NoneNo IPR availablePANTHERPTHR16255UNCHARACTERIZEDcoord: 30..320